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Aliases for GPR158 Gene

Aliases for GPR158 Gene

  • G Protein-Coupled Receptor 158 2 3 5
  • KIAA1136 4

External Ids for GPR158 Gene

Previous GeneCards Identifiers for GPR158 Gene

  • GC10P025467
  • GC10P025504

Summaries for GPR158 Gene

GeneCards Summary for GPR158 Gene

GPR158 (G Protein-Coupled Receptor 158) is a Protein Coding gene. Diseases associated with GPR158 include smallpox. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR179.

UniProtKB/Swiss-Prot for GPR158 Gene

  • Orphan receptor.

Gene Wiki entry for GPR158 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR158 Gene

Genomics for GPR158 Gene

Regulatory Elements for GPR158 Gene

Promoters for GPR158 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPR158 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR158 Gene

Chromosome:
10
Start:
25,174,737 bp from pter
End:
25,602,233 bp from pter
Size:
427,497 bases
Orientation:
Plus strand

Genomic View for GPR158 Gene

Genes around GPR158 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR158 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR158 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR158 Gene

Proteins for GPR158 Gene

  • Protein details for GPR158 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T848-GP158_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 158
    Protein Accession:
    Q5T848
    Secondary Accessions:
    • Q6QR81
    • Q9ULT3

    Protein attributes for GPR158 Gene

    Size:
    1215 amino acids
    Molecular mass:
    135489 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAS18315.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GPR158 Gene

Proteomics data for GPR158 Gene at MOPED

Post-translational modifications for GPR158 Gene

  • Ubiquitination at Lys 774
  • Glycosylation at Asn 98, Asn 143, Asn 215, Asn 274, and Asn 333
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR158 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GPR158 Gene

Domains & Families for GPR158 Gene

Gene Families for GPR158 Gene

Protein Domains for GPR158 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR158 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T848

UniProtKB/Swiss-Prot:

GP158_HUMAN :
  • Belongs to the G-protein coupled receptor 3 family.
Family:
  • Belongs to the G-protein coupled receptor 3 family.
genes like me logo Genes that share domains with GPR158: view

Function for GPR158 Gene

Molecular function for GPR158 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Gene Ontology (GO) - Molecular Function for GPR158 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with GPR158: view
genes like me logo Genes that share phenotypes with GPR158: view

Animal Models for GPR158 Gene

MGI Knock Outs for GPR158:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR158

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR158 Gene

Localization for GPR158 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR158 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR158 Gene COMPARTMENTS Subcellular localization image for GPR158 gene
Compartment Confidence
plasma membrane 5
cytosol 2
extracellular 2

Gene Ontology (GO) - Cellular Components for GPR158 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
genes like me logo Genes that share ontologies with GPR158: view

Pathways & Interactions for GPR158 Gene

SuperPathways for GPR158 Gene

No Data Available

Interacting Proteins for GPR158 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000365529%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q5T848-GP158_HUMAN ENSP00000365529 for GPR158 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for GPR158 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA,IBA --
genes like me logo Genes that share ontologies with GPR158: view

No data available for Pathways by source and SIGNOR curated interactions for GPR158 Gene

Drugs & Compounds for GPR158 Gene

No Compound Related Data Available

Transcripts for GPR158 Gene

mRNA/cDNA for GPR158 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(27) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR158 Gene

G protein-coupled receptor 158:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR158 Gene

No ASD Table

Relevant External Links for GPR158 Gene

GeneLoc Exon Structure for
GPR158
ECgene alternative splicing isoforms for
GPR158

Expression for GPR158 Gene

mRNA expression in normal human tissues for GPR158 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR158 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x9.3), Brain - Cerebellum (x6.3), Brain - Putamen (basal ganglia) (x5.5), Brain - Caudate (basal ganglia) (x4.8), Brain - Frontal Cortex (BA9) (x4.7), and Brain - Nucleus accumbens (basal ganglia) (x4.4).

Protein differential expression in normal tissues from HIPED for GPR158 Gene

This gene is overexpressed in Retina (32.4), Frontal cortex (25.0), and Peripheral blood mononuclear cells (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR158 Gene



SOURCE GeneReport for Unigene cluster for GPR158 Gene Hs.499108

genes like me logo Genes that share expression patterns with GPR158: view

Protein tissue co-expression partners for GPR158 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GPR158 Gene

Orthologs for GPR158 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPR158 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPR158 35
  • 87.29 (n)
  • 85.57 (a)
GPR158 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPR158 35
  • 90.13 (n)
  • 89.78 (a)
GPR158 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr158 35
  • 86.06 (n)
  • 87.25 (a)
Gpr158 16
Gpr158 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPR158 35
  • 99.62 (n)
  • 99.51 (a)
GPR158 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr158 35
  • 86.29 (n)
  • 87.73 (a)
oppossum
(Monodelphis domestica)
Mammalia GPR158 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 49 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
chicken
(Gallus gallus)
Aves GPR158 35
  • 75.25 (n)
  • 74.78 (a)
GPR158 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR158 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr158 35
  • 64 (n)
  • 60.92 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC570001 35
  • 60.62 (n)
  • 58.02 (a)
GPR158 (2 of 2) 36
  • 46 (a)
OneToMany
gpr158a 36
  • 45 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG31195 36
  • 10 (a)
ManyToMany
CG31760 36
  • 15 (a)
ManyToMany
CG43795 36
  • 14 (a)
ManyToMany
pog 36
  • 16 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F39B2.8 36
  • 20 (a)
OneToMany
Species with no ortholog for GPR158:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPR158 Gene

ENSEMBL:
Gene Tree for GPR158 (if available)
TreeFam:
Gene Tree for GPR158 (if available)

Paralogs for GPR158 Gene

Paralogs for GPR158 Gene

genes like me logo Genes that share paralogs with GPR158: view

Variants for GPR158 Gene

Sequence variations from dbSNP and Humsavar for GPR158 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs2480345 - 25,412,412(-) ACAGG(C/G)CTTGG nc-transcript-variant, reference, missense
rs10828833 - 25,599,251(+) AAGAG(A/G)TCTGG nc-transcript-variant, reference, missense
rs509285 -- 25,336,392(+) TAGCA(A/G)GTGTT intron-variant
rs511647 -- 25,318,311(+) TCACC(C/G/T)AGAAA intron-variant
rs516071 -- 25,332,401(+) TTTAC(C/T)TGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR158 Gene

Variant ID Type Subtype PubMed ID
dgv627n71 CNV Gain 21882294
esv2675139 CNV Deletion 23128226
esv271437 CNV Insertion 20981092
esv2659443 CNV Deletion 23128226
esv2664122 CNV Deletion 23128226
esv1180990 CNV Insertion 17803354
esv2492571 CNV Deletion 19546169
esv1997102 CNV Deletion 18987734
esv26962 CNV Loss 19812545
esv2662962 CNV Deletion 23128226
nsv25401 CNV Loss 16902084
esv2734184 CNV Deletion 23290073
esv2668854 CNV Deletion 23128226
nsv509345 CNV Insertion 20534489
esv268877 CNV Insertion 20981092
esv273379 CNV Insertion 20981092
nsv51 CNV Insertion 15895083
nsv6110 CNV Insertion 18451855
esv2673507 CNV Deletion 23128226
esv2734195 CNV Deletion 23290073
esv2656793 CNV Deletion 23128226
nsv894972 CNV Loss 21882294

Variation tolerance for GPR158 Gene

Residual Variation Intolerance Score: 21.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.98; 96.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR158 Gene

HapMap Linkage Disequilibrium report
GPR158

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR158 Gene

Disorders for GPR158 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPR158 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
smallpox
  • ordinary smallpox
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GPR158

Genetic Association Database (GAD)
GPR158
Human Genome Epidemiology (HuGE) Navigator
GPR158
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR158
genes like me logo Genes that share disorders with GPR158: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR158 Gene

Publications for GPR158 Gene

  1. Orphan Receptor GPR158 Is an Allosteric Modulator of RGS7 Catalytic Activity with an Essential Role in Dictating Its Expression and Localization in the Brain. (PMID: 25792749) Orlandi C. … Martemyanov K.A. (J. Biol. Chem. 2015) 2 3 67
  2. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PMID: 23382691) Lauc G. … Rudan I. (PLoS Genet. 2013) 3
  3. GPR158, an orphan member of G protein-coupled receptor Family C: glucocorticoid-stimulated expression and novel nuclear role. (PMID: 23451275) Patel N. … Fini M.E. (PLoS ONE 2013) 3
  4. Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. (PMID: 24324551) Deng X. … Seielstad M. (PLoS ONE 2013) 3
  5. Genome-wide association study of antibody response to smallpox vaccine. (PMID: 22542470) Ovsyannikova I.G. … Poland G.A. (Vaccine 2012) 3

Products for GPR158 Gene

Sources for GPR158 Gene

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