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Aliases for GPR158 Gene

Aliases for GPR158 Gene

  • G Protein-Coupled Receptor 158 2 3 5
  • KIAA1136 4

External Ids for GPR158 Gene

Previous GeneCards Identifiers for GPR158 Gene

  • GC10P025467
  • GC10P025504

Summaries for GPR158 Gene

GeneCards Summary for GPR158 Gene

GPR158 (G Protein-Coupled Receptor 158) is a Protein Coding gene. Diseases associated with GPR158 include Smallpox and Borderline Glaucoma. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR179.

UniProtKB/Swiss-Prot for GPR158 Gene

  • Orphan receptor.

Gene Wiki entry for GPR158 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR158 Gene

Genomics for GPR158 Gene

Regulatory Elements for GPR158 Gene

Enhancers for GPR158 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F024236 0.4 ENCODE 5.3 -935.8 -935792 4.5 PKNOX1 ZNF384 ZIC2 RARA TEAD3 GATA3 CTBP1 RERE SCRT2 NR2F6 GPR158 ENSG00000277563 GC10P024187
GH10F024951 0.6 FANTOM5 ENCODE 2 -222.0 -221951 3.4 HDGF ATF1 PKNOX1 CREB3L1 SIN3A ZNF2 GATA2 ZNF263 SP3 REST PRTFDC1 THNSL1 GPR158 ARHGAP21 ENSG00000273107 GC10M024909 RN7SKP241
GH10F024703 1.1 FANTOM5 ENCODE 1.8 -470.8 -470805 1.1 CREB3 ZNF316 MAFG NFE2 MAFK EMSY MGA ARHGAP21 GPR158 COQ10BP1
GH10F025350 0.3 FANTOM5 1.7 +175.4 175412 0.1 GPR158 RN7SKP220 ENSG00000274242
GH10F025444 0.4 FANTOM5 1.7 +270.1 270087 0.4 ZFHX2 YBX1 EGR2 GPR158 RN7SKP220 GPN3P1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GPR158 on UCSC Golden Path with GeneCards custom track

Promoters for GPR158 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001758630 163 1001 ATF1 PKNOX1 SIN3A FEZF1 ZNF2 SLC30A9 GLIS2 ZNF143 ZNF207 ZNF263

Genomic Location for GPR158 Gene

25,174,737 bp from pter
25,602,233 bp from pter
427,497 bases
Plus strand

Genomic View for GPR158 Gene

Genes around GPR158 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR158 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR158 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR158 Gene

Proteins for GPR158 Gene

  • Protein details for GPR158 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 158
    Protein Accession:
    Secondary Accessions:
    • Q6QR81
    • Q9ULT3

    Protein attributes for GPR158 Gene

    1215 amino acids
    Molecular mass:
    135489 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAS18315.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GPR158 Gene

Post-translational modifications for GPR158 Gene

  • Ubiquitination at Lys 774
  • Glycosylation at Asn 98, Asn 143, Asn 215, Asn 274, and Asn 333
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR158 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR158 Gene

Domains & Families for GPR158 Gene

Gene Families for GPR158 Gene

Protein Domains for GPR158 Gene


Suggested Antigen Peptide Sequences for GPR158 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 3 family.
  • Belongs to the G-protein coupled receptor 3 family.
genes like me logo Genes that share domains with GPR158: view

Function for GPR158 Gene

Molecular function for GPR158 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Gene Ontology (GO) - Molecular Function for GPR158 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GPR158: view
genes like me logo Genes that share phenotypes with GPR158: view

Animal Models for GPR158 Gene

MGI Knock Outs for GPR158:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR158

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR158 Gene

Localization for GPR158 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR158 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GPR158 Gene COMPARTMENTS Subcellular localization image for GPR158 gene
Compartment Confidence
plasma membrane 5
cytosol 2
extracellular 2

Gene Ontology (GO) - Cellular Components for GPR158 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR158: view

Pathways & Interactions for GPR158 Gene

SuperPathways for GPR158 Gene

No Data Available

Interacting Proteins for GPR158 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q5T848-GP158_HUMAN ENSP00000365529 for GPR158 Gene via IID STRING

Gene Ontology (GO) - Biological Process for GPR158 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0072659 protein localization to plasma membrane IEA --
genes like me logo Genes that share ontologies with GPR158: view

No data available for Pathways by source and SIGNOR curated interactions for GPR158 Gene

Transcripts for GPR158 Gene

mRNA/cDNA for GPR158 Gene

Unigene Clusters for GPR158 Gene

G protein-coupled receptor 158:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR158 Gene

No ASD Table

Relevant External Links for GPR158 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR158 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR158 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR158 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x9.3), Brain - Cerebellum (x6.3), Brain - Putamen (basal ganglia) (x5.5), Brain - Caudate (basal ganglia) (x4.8), Brain - Frontal Cortex (BA9) (x4.7), and Brain - Nucleus accumbens (basal ganglia) (x4.4).

Protein differential expression in normal tissues from HIPED for GPR158 Gene

This gene is overexpressed in Retina (32.4), Frontal cortex (25.0), and Peripheral blood mononuclear cells (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR158 Gene

Protein tissue co-expression partners for GPR158 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPR158 Gene:


SOURCE GeneReport for Unigene cluster for GPR158 Gene:

genes like me logo Genes that share expression patterns with GPR158: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for GPR158 Gene

Orthologs for GPR158 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPR158 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR158 34 35
  • 99.62 (n)
(Canis familiaris)
Mammalia GPR158 34 35
  • 90.13 (n)
(Bos Taurus)
Mammalia GPR158 34 35
  • 87.29 (n)
(Rattus norvegicus)
Mammalia Gpr158 34
  • 86.29 (n)
(Mus musculus)
Mammalia Gpr158 34 16 35
  • 86.06 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 86 (a)
-- 35
  • 49 (a)
(Monodelphis domestica)
Mammalia GPR158 35
  • 79 (a)
(Gallus gallus)
Aves GPR158 34 35
  • 75.25 (n)
(Anolis carolinensis)
Reptilia GPR158 35
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr158 34
  • 64 (n)
(Danio rerio)
Actinopterygii LOC570001 34
  • 60.62 (n)
GPR158 (2 of 2) 35
  • 46 (a)
gpr158a 35
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta pog 35
  • 16 (a)
CG31760 35
  • 15 (a)
CG43795 35
  • 14 (a)
CG31195 35
  • 10 (a)
(Caenorhabditis elegans)
Secernentea F39B2.8 35
  • 20 (a)
Species where no ortholog for GPR158 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPR158 Gene

Gene Tree for GPR158 (if available)
Gene Tree for GPR158 (if available)

Paralogs for GPR158 Gene

Paralogs for GPR158 Gene

genes like me logo Genes that share paralogs with GPR158: view

Variants for GPR158 Gene

Sequence variations from dbSNP and Humsavar for GPR158 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1001948 -- 25,177,764(+) AATAA(A/C)CCCCT intron-variant, upstream-variant-2KB
rs10047266 -- 25,522,906(+) AGATG(G/T)CAAGG intron-variant
rs10082438 -- 25,543,132(+) TTTTT(A/T)TTTTT intron-variant
rs10082439 -- 25,543,282(+) TGCCC(A/G)GCTAA intron-variant
rs10082450 -- 25,543,130(+) TATTT(A/T)TATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR158 Gene

Variant ID Type Subtype PubMed ID
esv1180990 CNV insertion 17803354
esv1997102 CNV deletion 18987734
esv2492571 CNV deletion 19546169
esv2656793 CNV deletion 23128226
esv2659443 CNV deletion 23128226
esv2662962 CNV deletion 23128226
esv2664122 CNV deletion 23128226
esv2668854 CNV deletion 23128226
esv2673507 CNV deletion 23128226
esv2675139 CNV deletion 23128226
esv26962 CNV loss 19812545
esv2734184 CNV deletion 23290073
esv2734195 CNV deletion 23290073
esv2760120 CNV loss 21179565
esv2760160 CNV loss 21179565
esv2761583 CNV gain 21179565
esv2761584 CNV loss 21179565
esv3307161 CNV mobile element insertion 20981092
esv3351033 CNV insertion 20981092
esv3361013 CNV insertion 20981092
esv3394342 CNV insertion 20981092
esv3546035 CNV deletion 23714750
esv3546036 CNV deletion 23714750
esv3546038 CNV deletion 23714750
esv3622660 CNV loss 21293372
esv3622662 CNV gain 21293372
esv3622663 CNV loss 21293372
esv3622665 CNV loss 21293372
esv3622666 CNV loss 21293372
esv3622668 CNV gain 21293372
esv3622669 CNV loss 21293372
esv3622670 CNV loss 21293372
nsv1044482 CNV gain 25217958
nsv1124613 CNV duplication 24896259
nsv1139518 CNV duplication 24896259
nsv25401 CNV deletion 16902084
nsv476033 CNV novel sequence insertion 20440878
nsv509345 CNV insertion 20534489
nsv51 CNV insertion 15895083
nsv550225 CNV loss 21841781
nsv550226 CNV loss 21841781
nsv550227 CNV loss 21841781
nsv6110 CNV insertion 18451855
nsv947771 CNV duplication 23825009
nsv947772 CNV duplication 23825009

Variation tolerance for GPR158 Gene

Residual Variation Intolerance Score: 21.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.98; 96.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR158 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR158 Gene

Disorders for GPR158 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GPR158 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • ordinary smallpox
borderline glaucoma
  • preglaucoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GPR158

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GPR158: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR158 Gene

Publications for GPR158 Gene

  1. Orphan Receptor GPR158 Is an Allosteric Modulator of RGS7 Catalytic Activity with an Essential Role in Dictating Its Expression and Localization in the Brain. (PMID: 25792749) Orlandi C. … Martemyanov K.A. (J. Biol. Chem. 2015) 2 3 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Replication of a genome-wide case-control study of esophageal squamous cell carcinoma. (PMID: 18649358) Ng D. … Taylor P.R. (Int. J. Cancer 2008) 3 46 64
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64

Products for GPR158 Gene

Sources for GPR158 Gene

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