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Aliases for GPR158 Gene

Aliases for GPR158 Gene

  • G Protein-Coupled Receptor 158 2 3
  • KIAA1136 4

External Ids for GPR158 Gene

Previous GeneCards Identifiers for GPR158 Gene

  • GC10P025467
  • GC10P025504

Summaries for GPR158 Gene

GeneCards Summary for GPR158 Gene

GPR158 (G Protein-Coupled Receptor 158) is a Protein Coding gene. Diseases associated with GPR158 include smallpox. GO annotations related to this gene include G-protein coupled receptor activity.

UniProtKB/Swiss-Prot for GPR158 Gene

  • Orphan receptor

Gene Wiki entry for GPR158 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR158 Gene

Genomics for GPR158 Gene

Regulatory Elements for GPR158 Gene

Genomic Location for GPR158 Gene

25,174,737 bp from pter
25,602,233 bp from pter
427,497 bases
Plus strand

Genomic View for GPR158 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPR158 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR158 Gene

Proteins for GPR158 Gene

  • Protein details for GPR158 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 158
    Protein Accession:
    Secondary Accessions:
    • Q6QR81
    • Q9ULT3

    Protein attributes for GPR158 Gene

    1215 amino acids
    Molecular mass:
    135489 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAS18315.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GPR158 Gene

Proteomics data for GPR158 Gene at MOPED

Post-translational modifications for GPR158 Gene

  • Ubiquitination at Lys 774
  • Glycosylation at Asn 98, Asn 143, Asn 215, Asn 274, and Asn 333
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR158 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GPR158 Gene

Domains & Families for GPR158 Gene

Gene Families for GPR158 Gene

Protein Domains for GPR158 Gene


Suggested Antigen Peptide Sequences for GPR158 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 3 family.
  • Belongs to the G-protein coupled receptor 3 family.
genes like me logo Genes that share domains with GPR158: view

Function for GPR158 Gene

Molecular function for GPR158 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor

Gene Ontology (GO) - Molecular Function for GPR158 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with GPR158: view
genes like me logo Genes that share phenotypes with GPR158: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPR158

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR158 Gene

Localization for GPR158 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR158 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GPR158 Gene COMPARTMENTS Subcellular localization image for GPR158 gene
Compartment Confidence
plasma membrane 5
cytosol 2

Gene Ontology (GO) - Cellular Components for GPR158 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR158: view

Pathways & Interactions for GPR158 Gene

SuperPathways for GPR158 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • G Protein Coupled Receptors 384HT in human,mouse,rat

Interacting Proteins for GPR158 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q5T848-GP158_HUMAN ENSP00000365529 for GPR158 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for GPR158 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway IEA --
GO:0072659 protein localization to plasma membrane IEA --
genes like me logo Genes that share ontologies with GPR158: view

No data available for Pathways by source and SIGNOR curated interactions for GPR158 Gene

Drugs & Compounds for GPR158 Gene

No Compound Related Data Available

Transcripts for GPR158 Gene

mRNA/cDNA for GPR158 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(27) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR158 Gene

G protein-coupled receptor 158:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPR158

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR158 Gene

No ASD Table

Relevant External Links for GPR158 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR158 Gene

mRNA expression in normal human tissues for GPR158 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR158 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x9.3), Brain - Cerebellum (x6.3), Brain - Putamen (basal ganglia) (x5.5), Brain - Caudate (basal ganglia) (x4.8), Brain - Frontal Cortex (BA9) (x4.7), and Brain - Nucleus accumbens (basal ganglia) (x4.4).

Protein differential expression in normal tissues from HIPED for GPR158 Gene

This gene is overexpressed in Retina (32.4), Frontal cortex (25.0), and Peripheral blood mononuclear cells (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR158 Gene

SOURCE GeneReport for Unigene cluster for GPR158 Gene Hs.499108

genes like me logo Genes that share expression patterns with GPR158: view

Protein tissue co-expression partners for GPR158 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GPR158 Gene

Orthologs for GPR158 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPR158 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPR158 35
  • 87.29 (n)
  • 85.57 (a)
GPR158 36
  • 85 (a)
(Canis familiaris)
Mammalia GPR158 35
  • 90.13 (n)
  • 89.78 (a)
GPR158 36
  • 90 (a)
(Mus musculus)
Mammalia Gpr158 35
  • 86.06 (n)
  • 87.25 (a)
Gpr158 16
Gpr158 36
  • 87 (a)
(Pan troglodytes)
Mammalia GPR158 35
  • 99.62 (n)
  • 99.51 (a)
GPR158 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Gpr158 35
  • 86.29 (n)
  • 87.73 (a)
(Monodelphis domestica)
Mammalia GPR158 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 49 (a)
-- 36
  • 86 (a)
(Gallus gallus)
Aves GPR158 35
  • 75.25 (n)
  • 74.78 (a)
GPR158 36
  • 72 (a)
(Anolis carolinensis)
Reptilia GPR158 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr158 35
  • 64 (n)
  • 60.92 (a)
(Danio rerio)
Actinopterygii LOC570001 35
  • 60.62 (n)
  • 58.02 (a)
GPR158 (2 of 2) 36
  • 46 (a)
gpr158a 36
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31195 36
  • 10 (a)
CG31760 36
  • 15 (a)
CG43795 36
  • 14 (a)
pog 36
  • 16 (a)
(Caenorhabditis elegans)
Secernentea F39B2.8 36
  • 20 (a)
Species with no ortholog for GPR158:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPR158 Gene

Gene Tree for GPR158 (if available)
Gene Tree for GPR158 (if available)

Paralogs for GPR158 Gene

No data available for Paralogs for GPR158 Gene

Variants for GPR158 Gene

Sequence variations from dbSNP and Humsavar for GPR158 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs476972 -- 25,343,278(+) AATAG(C/G)AGGAG intron-variant
rs489052 -- 25,343,203(+) TTTCC(A/G)AAATT intron-variant
rs489186 -- 25,343,251(+) ACTCT(C/T)TTTCT intron-variant
rs495338 -- 25,331,558(-) AATGT(G/T)TAAGT intron-variant
rs495456 -- 25,343,902(+) AGGAA(A/G)GCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR158 Gene

Variant ID Type Subtype PubMed ID
dgv627n71 CNV Gain 21882294
esv2675139 CNV Deletion 23128226
esv271437 CNV Insertion 20981092
esv2659443 CNV Deletion 23128226
esv2664122 CNV Deletion 23128226
esv1180990 CNV Insertion 17803354
esv2492571 CNV Deletion 19546169
esv1997102 CNV Deletion 18987734
esv26962 CNV Loss 19812545
esv2662962 CNV Deletion 23128226
nsv25401 CNV Loss 16902084
esv2734184 CNV Deletion 23290073
esv2668854 CNV Deletion 23128226
nsv509345 CNV Insertion 20534489
esv268877 CNV Insertion 20981092
esv273379 CNV Insertion 20981092
nsv51 CNV Insertion 15895083
nsv6110 CNV Insertion 18451855
esv2673507 CNV Deletion 23128226
esv2734195 CNV Deletion 23290073
esv2656793 CNV Deletion 23128226
nsv894972 CNV Loss 21882294

Variation tolerance for GPR158 Gene

Residual Variation Intolerance Score: 21.07% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.98; 96.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR158 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR158 Gene

Disorders for GPR158 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPR158 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • ordinary smallpox
- elite association

Relevant External Links for GPR158

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GPR158: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR158 Gene

Publications for GPR158 Gene

  1. The presence of aberrant DNA methylation in noncancerous esophageal mucosae in association with smoking history: a target for risk diagnosis and prevention of esophageal cancers. (PMID: 19472401) Oka D. … Ushijima T. (Cancer 2009) 23 67
  2. Orphan Receptor GPR158 Is an Allosteric Modulator of RGS7 Catalytic Activity with an Essential Role in Dictating Its Expression and Localization in the Brain. (PMID: 25792749) Orlandi C. … Martemyanov K.A. (J. Biol. Chem. 2015) 67
  3. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PMID: 23382691) Lauc G. … Rudan I. (PLoS Genet. 2013) 67
  4. Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. (PMID: 24324551) Deng X. … Seielstad M. (PLoS ONE 2013) 67
  5. GPR158, an orphan member of G protein-coupled receptor Family C: glucocorticoid-stimulated expression and novel nuclear role. (PMID: 23451275) Patel N. … Fini M.E. (PLoS ONE 2013) 67

Products for GPR158 Gene

Sources for GPR158 Gene

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