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Aliases for GPR157 Gene

Aliases for GPR157 Gene

  • G Protein-Coupled Receptor 157 2 3 5

External Ids for GPR157 Gene

Previous GeneCards Identifiers for GPR157 Gene

  • GC01M008896
  • GC01M009121
  • GC01M008314
  • GC01M009162

Summaries for GPR157 Gene

GeneCards Summary for GPR157 Gene

GPR157 (G Protein-Coupled Receptor 157) is a Protein Coding gene. Diseases associated with GPR157 include Stromal Dystrophy. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity.

UniProtKB/Swiss-Prot for GPR157 Gene

  • Orphan receptor that promotes neuronal differentiation of radial glial progenitors (RGPs). The activity of this receptor is mediated by a G(q)-protein that activates a phosphatidylinositol-calcium second messenger.

Gene Wiki entry for GPR157 Gene

Additional gene information for GPR157 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR157 Gene

Genomics for GPR157 Gene

GeneHancer (GH) Regulatory Elements for GPR157 Gene

Promoters and enhancers for GPR157 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I009127 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 556.3 +0.4 391 3.4 HDGF ARID4B SIN3A DMAP1 GLI4 ZNF2 ZNF48 ZNF121 GLIS2 ZNF207 GPR157 PIR37771 SLC2A5
GH01I008869 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.5 +253.4 253380 11.8 CLOCK DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 ZNF263 SP3 NFYC ENO1 LOC102724552 MIR34AHG RERE GPR157 CLSTN1 PIK3CD-AS2 SLC45A1 H6PD ENO1-IT1
GH01I010031 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 14.4 -904.2 -904194 4.2 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 GC01M010031 PIR54123 UBE4B TARDBP LZIC GPR157 CASZ1 KIF1B RBP7 PGD
GH01I009942 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 14.4 -814.0 -814041 2.4 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 LZIC NMNAT1 ENSG00000228150 MIR34AHG GPR157 CASZ1 RBP7
GH01I009232 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.3 -105.3 -105311 3.3 HDGF FOXA2 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 H6PD GC01M009234 GPR157 SLC2A5 GC01P009203
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GPR157 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR157 gene promoter:

Genomic Locations for GPR157 Gene

Genomic Locations for GPR157 Gene
chr1:9,100,305-9,129,170
(GRCh38/hg38)
Size:
28,866 bases
Orientation:
Minus strand
chr1:9,160,364-9,189,229
(GRCh37/hg19)

Genomic View for GPR157 Gene

Genes around GPR157 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR157 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR157 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR157 Gene

Proteins for GPR157 Gene

  • Protein details for GPR157 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5UAW9-GP157_HUMAN
    Recommended name:
    G-protein coupled receptor 157
    Protein Accession:
    Q5UAW9
    Secondary Accessions:
    • A2A334
    • Q8WWB8
    • Q9HA73

    Protein attributes for GPR157 Gene

    Size:
    335 amino acids
    Molecular mass:
    36623 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB13982.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

neXtProt entry for GPR157 Gene

Post-translational modifications for GPR157 Gene

No Post-translational modifications

Other Protein References for GPR157 Gene

No data available for DME Specific Peptides for GPR157 Gene

Domains & Families for GPR157 Gene

Gene Families for GPR157 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR157 Gene

Suggested Antigen Peptide Sequences for GPR157 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5UAW9

UniProtKB/Swiss-Prot:

GP157_HUMAN :
  • Belongs to the G-protein coupled receptor 2 family.
Family:
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with GPR157: view

Function for GPR157 Gene

Molecular function for GPR157 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor that promotes neuronal differentiation of radial glial progenitors (RGPs). The activity of this receptor is mediated by a G(q)-protein that activates a phosphatidylinositol-calcium second messenger.

Phenotypes From GWAS Catalog for GPR157 Gene

Gene Ontology (GO) - Molecular Function for GPR157 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G-protein coupled receptor activity ISS --
genes like me logo Genes that share ontologies with GPR157: view
genes like me logo Genes that share phenotypes with GPR157: view

Animal Model Products

CRISPR Products

miRNA for GPR157 Gene

miRTarBase miRNAs that target GPR157

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR157 Gene

Localization for GPR157 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR157 Gene

Cell projection, cilium membrane; Multi-pass membrane protein. Note=Expressed in the primary cilia of radial glial progenitors (RGPs) exposed to the cerebrospinal fluid. {ECO:0000250 UniProtKB:Q8C206}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR157 gene
Compartment Confidence
plasma membrane 5
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (1)
  • Nucleoli (1)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPR157 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0042995 cell projection IEA --
GO:0060170 ciliary membrane ISS --
genes like me logo Genes that share ontologies with GPR157: view

Pathways & Interactions for GPR157 Gene

SuperPathways for GPR157 Gene

No Data Available

Interacting Proteins for GPR157 Gene

Selected Interacting proteins: Q5UAW9-GP157_HUMAN for GPR157 Gene via IID

Gene Ontology (GO) - Biological Process for GPR157 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway ISS --
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with GPR157: view

No data available for Pathways by source and SIGNOR curated interactions for GPR157 Gene

Drugs & Compounds for GPR157 Gene

No Compound Related Data Available

Transcripts for GPR157 Gene

mRNA/cDNA for GPR157 Gene

(3) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR157 Gene

G protein-coupled receptor 157:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR157 Gene

No ASD Table

Relevant External Links for GPR157 Gene

GeneLoc Exon Structure for
GPR157
ECgene alternative splicing isoforms for
GPR157

Expression for GPR157 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR157 Gene

mRNA differential expression in normal tissues according to GTEx for GPR157 Gene

This gene is overexpressed in Esophagus - Mucosa (x6.3), Muscle - Skeletal (x5.1), and Skin - Sun Exposed (Lower leg) (x4.5).

Protein differential expression in normal tissues from HIPED for GPR157 Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR157 Gene



Protein tissue co-expression partners for GPR157 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPR157 Gene:

GPR157

SOURCE GeneReport for Unigene cluster for GPR157 Gene:

Hs.632367
genes like me logo Genes that share expression patterns with GPR157: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR157 Gene

Orthologs for GPR157 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR157 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR157 33 34
  • 98.55 (n)
dog
(Canis familiaris)
Mammalia GPR157 33 34
  • 88.3 (n)
cow
(Bos Taurus)
Mammalia GPR157 33 34
  • 85.61 (n)
mouse
(Mus musculus)
Mammalia Gpr157 33 16 34
  • 84.3 (n)
rat
(Rattus norvegicus)
Mammalia Gpr157 33
  • 83.23 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GPR157 34
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPR157 34
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR157 33 34
  • 70.48 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr157 33
  • 64.45 (n)
zebrafish
(Danio rerio)
Actinopterygii gpr157 33 34
  • 63.74 (n)
Species where no ortholog for GPR157 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR157 Gene

ENSEMBL:
Gene Tree for GPR157 (if available)
TreeFam:
Gene Tree for GPR157 (if available)

Paralogs for GPR157 Gene

Pseudogenes.org Pseudogenes for GPR157 Gene

genes like me logo Genes that share paralogs with GPR157: view

No data available for Paralogs for GPR157 Gene

Variants for GPR157 Gene

Sequence variations from dbSNP and Humsavar for GPR157 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000009881 -- 9,119,599(-) G/A intron_variant
rs1000099860 -- 9,112,864(-) A/G intron_variant
rs1000127255 -- 9,110,206(-) T/G intron_variant
rs1000235922 -- 9,118,586(-) G/C intron_variant
rs1000431049 -- 9,112,296(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GPR157 Gene

Variant ID Type Subtype PubMed ID
esv1519481 CNV insertion 17803354
esv2422210 CNV duplication 17116639
esv2675581 CNV deletion 23128226
esv3585164 CNV loss 21293372
esv3585165 CNV loss 21293372
nsv1077038 CNV deletion 25765185
nsv831981 CNV loss 17160897
nsv832092 CNV loss 17160897
nsv954649 CNV deletion 24416366

Variation tolerance for GPR157 Gene

Residual Variation Intolerance Score: 67.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.48; 85.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR157 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR157

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR157 Gene

Disorders for GPR157 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPR157 Gene - From: DISEASES

Disorder Aliases PubMed IDs
stromal dystrophy
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GPR157

genes like me logo Genes that share disorders with GPR157: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR157 Gene

Publications for GPR157 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for GPR157 Gene

Sources for GPR157 Gene

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