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Aliases for GPR157 Gene

Aliases for GPR157 Gene

  • G Protein-Coupled Receptor 157 2 3 5

External Ids for GPR157 Gene

Previous GeneCards Identifiers for GPR157 Gene

  • GC01M008896
  • GC01M009121
  • GC01M008314
  • GC01M009162

Summaries for GPR157 Gene

GeneCards Summary for GPR157 Gene

GPR157 (G Protein-Coupled Receptor 157) is a Protein Coding gene. Diseases associated with GPR157 include Stromal Dystrophy. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity.

UniProtKB/Swiss-Prot for GPR157 Gene

  • Orphan receptor.

Gene Wiki entry for GPR157 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR157 Gene

Genomics for GPR157 Gene

Regulatory Elements for GPR157 Gene

Enhancers for GPR157 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F009084 1.1 Ensembl ENCODE 19.8 +43.7 43670 2.2 KLF1 ATF1 SAP130 JUN ZNF223 ZMYM3 CEBPG RAD21 RARA ZNF335 GPR157 ENSG00000252404 SLC2A5
GH01F009162 1.7 FANTOM5 Ensembl ENCODE 12 -35.4 -35429 5.1 HDGF PKNOX1 ARID4B FEZF1 ZNF2 YY1 FOS SP3 JUNB REST H6PD GPR157 LOC102724552 MIR34A LINC01759 SLC2A5 SPSB1 GC01M009163 GC01M009171
GH01F009092 0.9 FANTOM5 Ensembl 19.7 +35.5 35476 1.4 ZNF589 L3MBTL2 ZFP64 MGA NR2C2 GPR157 SLC2A5 PIR42185
GH01F009434 1.6 FANTOM5 Ensembl ENCODE 10.5 -310.5 -310513 10.9 PKNOX1 MLX CREB3L1 ARID4B DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF207 GPR157 MIR34A SPSB1 RNA5SP40 GC01P009482
GH01F009237 1.4 FANTOM5 ENCODE 11.4 -112.7 -112658 8.2 PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 YY1 FOS PAF1 SP5 H6PD GPR157 MIR34A PIR53045
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPR157 on UCSC Golden Path with GeneCards custom track

Promoters for GPR157 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000530215 570 2801 HDGF PKNOX1 ARID4B SIN3A GLI4 DMAP1 ZNF2 ZNF48 ZNF121 GLIS2

Genomic Location for GPR157 Gene

9,100,305 bp from pter
9,129,170 bp from pter
28,866 bases
Minus strand

Genomic View for GPR157 Gene

Genes around GPR157 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR157 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR157 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR157 Gene

Proteins for GPR157 Gene

  • Protein details for GPR157 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 157
    Protein Accession:
    Secondary Accessions:
    • A2A334
    • Q8WWB8
    • Q9HA73

    Protein attributes for GPR157 Gene

    335 amino acids
    Molecular mass:
    36623 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB13982.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

neXtProt entry for GPR157 Gene

Post-translational modifications for GPR157 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPR157 Gene

Antibody Products

  • Abcam antibodies for GPR157
  • Santa Cruz Biotechnology (SCBT) Antibodies for GPR157

No data available for DME Specific Peptides for GPR157 Gene

Domains & Families for GPR157 Gene

Gene Families for GPR157 Gene

Protein Domains for GPR157 Gene

Suggested Antigen Peptide Sequences for GPR157 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 2 family.
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with GPR157: view

Function for GPR157 Gene

Molecular function for GPR157 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Gene Ontology (GO) - Molecular Function for GPR157 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GPR157: view
genes like me logo Genes that share phenotypes with GPR157: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR157

miRNA for GPR157 Gene

miRTarBase miRNAs that target GPR157

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR157 Gene

Localization for GPR157 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR157 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR157 gene
Compartment Confidence
plasma membrane 5
nucleus 2

Gene Ontology (GO) - Cellular Components for GPR157 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR157: view

Pathways & Interactions for GPR157 Gene

SuperPathways for GPR157 Gene

No Data Available

Interacting Proteins for GPR157 Gene

Selected Interacting proteins: Q5UAW9-GP157_HUMAN for GPR157 Gene via IID

Gene Ontology (GO) - Biological Process for GPR157 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR157: view

No data available for Pathways by source and SIGNOR curated interactions for GPR157 Gene

Transcripts for GPR157 Gene

mRNA/cDNA for GPR157 Gene

(3) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR157 Gene

G protein-coupled receptor 157:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR157 Gene

No ASD Table

Relevant External Links for GPR157 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR157 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR157 Gene

mRNA differential expression in normal tissues according to GTEx for GPR157 Gene

This gene is overexpressed in Esophagus - Mucosa (x6.3), Muscle - Skeletal (x5.1), and Skin - Sun Exposed (Lower leg) (x4.5).

Protein differential expression in normal tissues from HIPED for GPR157 Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR157 Gene

Protein tissue co-expression partners for GPR157 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPR157 Gene:


SOURCE GeneReport for Unigene cluster for GPR157 Gene:

genes like me logo Genes that share expression patterns with GPR157: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for GPR157 Gene

Orthologs for GPR157 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR157 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR157 34 35
  • 98.55 (n)
(Canis familiaris)
Mammalia GPR157 34 35
  • 88.3 (n)
(Bos Taurus)
Mammalia GPR157 34 35
  • 85.61 (n)
(Mus musculus)
Mammalia Gpr157 34 16 35
  • 84.3 (n)
(Rattus norvegicus)
Mammalia Gpr157 34
  • 83.23 (n)
(Ornithorhynchus anatinus)
Mammalia GPR157 35
  • 77 (a)
(Monodelphis domestica)
Mammalia GPR157 35
  • 62 (a)
(Gallus gallus)
Aves GPR157 34 35
  • 70.48 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr157 34
  • 64.45 (n)
(Danio rerio)
Actinopterygii gpr157 34 35
  • 63.74 (n)
Species where no ortholog for GPR157 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR157 Gene

Gene Tree for GPR157 (if available)
Gene Tree for GPR157 (if available)

Paralogs for GPR157 Gene Pseudogenes for GPR157 Gene

genes like me logo Genes that share paralogs with GPR157: view

No data available for Paralogs for GPR157 Gene

Variants for GPR157 Gene

Sequence variations from dbSNP and Humsavar for GPR157 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10864389 -- 9,106,730(+) aggcc(A/G)aggtg intron-variant
rs10864390 -- 9,122,855(+) GTCCA(C/T)GGACA intron-variant
rs11121324 -- 9,110,867(+) AGCCC(A/G)GCCTT intron-variant
rs11121325 -- 9,111,853(+) taatc(C/T)cagct intron-variant
rs11121326 -- 9,114,265(+) TGGAG(C/G)TTGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR157 Gene

Variant ID Type Subtype PubMed ID
nsv954649 CNV deletion 24416366
nsv832092 CNV loss 17160897
nsv831981 CNV loss 17160897
nsv1077038 CNV deletion 25765185
esv3585165 CNV loss 21293372
esv3585164 CNV loss 21293372
esv2675581 CNV deletion 23128226
esv2422210 CNV duplication 17116639
esv1519481 CNV insertion 17803354

Variation tolerance for GPR157 Gene

Residual Variation Intolerance Score: 67.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.48; 85.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR157 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR157 Gene

Disorders for GPR157 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPR157 Gene - From: DISEASES

Disorder Aliases PubMed IDs
stromal dystrophy
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GPR157

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GPR157: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR157 Gene

Publications for GPR157 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 2 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for GPR157 Gene

Sources for GPR157 Gene

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