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Aliases for GPR157 Gene

Aliases for GPR157 Gene

  • G Protein-Coupled Receptor 157 2 3 5

External Ids for GPR157 Gene

Previous GeneCards Identifiers for GPR157 Gene

  • GC01M008896
  • GC01M009121
  • GC01M008314
  • GC01M009162

Summaries for GPR157 Gene

GeneCards Summary for GPR157 Gene

GPR157 (G Protein-Coupled Receptor 157) is a Protein Coding gene. Diseases associated with GPR157 include stromal dystrophy. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity.

UniProtKB/Swiss-Prot for GPR157 Gene

  • Orphan receptor.

Gene Wiki entry for GPR157 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR157 Gene

Genomics for GPR157 Gene

Regulatory Elements for GPR157 Gene

Promoters for GPR157 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPR157 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR157 Gene

Chromosome:
1
Start:
9,100,305 bp from pter
End:
9,129,170 bp from pter
Size:
28,866 bases
Orientation:
Minus strand

Genomic View for GPR157 Gene

Genes around GPR157 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR157 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR157 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR157 Gene

Proteins for GPR157 Gene

  • Protein details for GPR157 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5UAW9-GP157_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 157
    Protein Accession:
    Q5UAW9
    Secondary Accessions:
    • A2A334
    • Q8WWB8
    • Q9HA73

    Protein attributes for GPR157 Gene

    Size:
    335 amino acids
    Molecular mass:
    36623 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB13982.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

neXtProt entry for GPR157 Gene

Proteomics data for GPR157 Gene at MOPED

Post-translational modifications for GPR157 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPR157 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GPR157 Gene

Domains & Families for GPR157 Gene

Gene Families for GPR157 Gene

Protein Domains for GPR157 Gene

Suggested Antigen Peptide Sequences for GPR157 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5UAW9

UniProtKB/Swiss-Prot:

GP157_HUMAN :
  • Belongs to the G-protein coupled receptor 2 family.
Family:
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with GPR157: view

Function for GPR157 Gene

Molecular function for GPR157 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.
genes like me logo Genes that share phenotypes with GPR157: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR157

miRNA for GPR157 Gene

miRTarBase miRNAs that target GPR157

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR157 Gene

Localization for GPR157 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR157 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR157 Gene COMPARTMENTS Subcellular localization image for GPR157 gene
Compartment Confidence
plasma membrane 5
nucleus 2

Gene Ontology (GO) - Cellular Components for GPR157 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with GPR157: view

Pathways & Interactions for GPR157 Gene

SuperPathways for GPR157 Gene

No Data Available

Interacting Proteins for GPR157 Gene

Gene Ontology (GO) - Biological Process for GPR157 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GPR157 Gene

Drugs & Compounds for GPR157 Gene

No Compound Related Data Available

Transcripts for GPR157 Gene

mRNA/cDNA for GPR157 Gene

(3) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR157 Gene

G protein-coupled receptor 157:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR157 Gene

No ASD Table

Relevant External Links for GPR157 Gene

GeneLoc Exon Structure for
GPR157
ECgene alternative splicing isoforms for
GPR157

Expression for GPR157 Gene

mRNA expression in normal human tissues for GPR157 Gene

mRNA differential expression in normal tissues according to GTEx for GPR157 Gene

This gene is overexpressed in Esophagus - Mucosa (x6.3), Muscle - Skeletal (x5.1), and Skin - Sun Exposed (Lower leg) (x4.5).

Protein differential expression in normal tissues from HIPED for GPR157 Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR157 Gene



SOURCE GeneReport for Unigene cluster for GPR157 Gene Hs.632367

genes like me logo Genes that share expression patterns with GPR157: view

Protein tissue co-expression partners for GPR157 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for GPR157 Gene

Orthologs for GPR157 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR157 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR157 36
  • 98 (a)
OneToOne
GPR157 35
  • 98.55 (n)
  • 98.07 (a)
cow
(Bos Taurus)
Mammalia GPR157 36
  • 84 (a)
OneToOne
GPR157 35
  • 85.61 (n)
  • 85.71 (a)
dog
(Canis familiaris)
Mammalia GPR157 35
  • 88.3 (n)
  • 88.82 (a)
GPR157 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr157 16
Gpr157 36
  • 86 (a)
OneToOne
Gpr157 35
  • 84.3 (n)
  • 87.77 (a)
oppossum
(Monodelphis domestica)
Mammalia GPR157 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR157 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr157 35
  • 83.23 (n)
  • 86.2 (a)
chicken
(Gallus gallus)
Aves GPR157 35
  • 70.48 (n)
  • 68.07 (a)
GPR157 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr157 35
  • 64.45 (n)
  • 65.73 (a)
zebrafish
(Danio rerio)
Actinopterygii gpr157 36
  • 57 (a)
OneToOne
gpr157 35
  • 63.74 (n)
  • 63.16 (a)
Species with no ortholog for GPR157:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR157 Gene

ENSEMBL:
Gene Tree for GPR157 (if available)
TreeFam:
Gene Tree for GPR157 (if available)

Paralogs for GPR157 Gene

Pseudogenes.org Pseudogenes for GPR157 Gene

genes like me logo Genes that share paralogs with GPR157: view

No data available for Paralogs for GPR157 Gene

Variants for GPR157 Gene

Sequence variations from dbSNP and Humsavar for GPR157 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs770020 -- 9,126,950(+) CTGCA(A/G)TCATA intron-variant
rs770029 -- 9,110,758(+) AATTC(C/T)GGAAA intron-variant
rs770030 -- 9,109,683(-) ggtgc(A/G)gtagc intron-variant
rs770031 -- 9,109,660(-) tccca(A/G)cagtt intron-variant
rs1705299 -- 9,117,258(-) ATCCT(A/G)TGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR157 Gene

Variant ID Type Subtype PubMed ID
nsv831981 CNV Loss 17160897
esv2422210 CNV Duplication 17116639
nsv871145 CNV Loss 21882294
esv2675581 CNV Deletion 23128226
esv1519481 CNV Insertion 17803354
nsv832092 CNV Loss 17160897

Variation tolerance for GPR157 Gene

Residual Variation Intolerance Score: 67.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.48; 85.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR157 Gene

HapMap Linkage Disequilibrium report
GPR157

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR157 Gene

Disorders for GPR157 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPR157 Gene - From: DISEASES

Disorder Aliases PubMed IDs
stromal dystrophy
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GPR157

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR157
genes like me logo Genes that share disorders with GPR157: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR157 Gene

Publications for GPR157 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 67
  2. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for GPR157 Gene

Sources for GPR157 Gene

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