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Aliases for GPR156 Gene

Aliases for GPR156 Gene

  • G Protein-Coupled Receptor 156 2 3 5
  • GABAB-Related G-Protein Coupled Receptor 3 4
  • G-Protein Coupled Receptor PGR28 3 4
  • GABABL 3 4
  • PGR28 3 4
  • G Protein-Coupled Receptor PGR28 3

External Ids for GPR156 Gene

Previous GeneCards Identifiers for GPR156 Gene

  • GC03M121206
  • GC03M121368
  • GC03M119883
  • GC03M117260

Summaries for GPR156 Gene

Entrez Gene Summary for GPR156 Gene

  • G protein-coupled receptors (GPCRs) are a large superfamily of cell surface receptors characterized by 7 helical transmembrane domains, together with N-terminal extracellular and C-terminal intracellular domains.[supplied by OMIM, Mar 2008]

GeneCards Summary for GPR156 Gene

GPR156 (G Protein-Coupled Receptor 156) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled GABA receptor activity. An important paralog of this gene is GABBR1.

UniProtKB/Swiss-Prot for GPR156 Gene

  • Orphan receptor.

Gene Wiki entry for GPR156 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR156 Gene

Genomics for GPR156 Gene

Regulatory Elements for GPR156 Gene

Enhancers for GPR156 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPR156 on UCSC Golden Path with GeneCards custom track

Promoters for GPR156 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPR156 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR156 Gene

120,164,645 bp from pter
120,285,124 bp from pter
120,480 bases
Minus strand

Genomic View for GPR156 Gene

Genes around GPR156 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR156 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR156 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR156 Gene

Proteins for GPR156 Gene

  • Protein details for GPR156 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 156
    Protein Accession:
    Secondary Accessions:
    • B7ZL66
    • E9PFZ4
    • Q14CM1
    • Q86SN6

    Protein attributes for GPR156 Gene

    814 amino acids
    Molecular mass:
    89097 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GPR156 Gene


neXtProt entry for GPR156 Gene

Proteomics data for GPR156 Gene at MOPED

Post-translational modifications for GPR156 Gene

  • Glycosylation at Asn 6
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR156 Gene

No data available for DME Specific Peptides for GPR156 Gene

Domains & Families for GPR156 Gene

Gene Families for GPR156 Gene

Protein Domains for GPR156 Gene


Suggested Antigen Peptide Sequences for GPR156 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
  • Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
genes like me logo Genes that share domains with GPR156: view

Function for GPR156 Gene

Molecular function for GPR156 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.
genes like me logo Genes that share phenotypes with GPR156: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR156

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR156 Gene

Localization for GPR156 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR156 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GPR156 Gene COMPARTMENTS Subcellular localization image for GPR156 gene
Compartment Confidence
plasma membrane 5
cytosol 2
golgi apparatus 2
nucleus 2

Gene Ontology (GO) - Cellular Components for GPR156 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with GPR156: view

Pathways & Interactions for GPR156 Gene

genes like me logo Genes that share pathways with GPR156: view

Pathways by source for GPR156 Gene

1 KEGG pathway for GPR156 Gene

Interacting Proteins for GPR156 Gene

Gene Ontology (GO) - Biological Process for GPR156 Gene


No data available for SIGNOR curated interactions for GPR156 Gene

Drugs & Compounds for GPR156 Gene

No Compound Related Data Available

Transcripts for GPR156 Gene

Unigene Clusters for GPR156 Gene

G protein-coupled receptor 156:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR156 Gene

No ASD Table

Relevant External Links for GPR156 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR156 Gene

mRNA expression in normal human tissues for GPR156 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR156 Gene

This gene is overexpressed in Testis (x10.9).

Protein differential expression in normal tissues from HIPED for GPR156 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR156 Gene

SOURCE GeneReport for Unigene cluster for GPR156 Gene Hs.333358

mRNA Expression by UniProt/SwissProt for GPR156 Gene

Tissue specificity: Ubiquitous expression both in the CNS and in peripheral tissues. Very high expression in fetal brain and testis relative to expression in other tissues.
genes like me logo Genes that share expression patterns with GPR156: view

Protein tissue co-expression partners for GPR156 Gene

Primer Products

Orthologs for GPR156 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPR156 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPR156 35
  • 84.76 (n)
  • 78.63 (a)
GPR156 36
  • 78 (a)
(Canis familiaris)
Mammalia GPR156 35
  • 82.15 (n)
  • 75.16 (a)
GPR156 36
  • 74 (a)
(Mus musculus)
Mammalia Gpr156 35
  • 78.25 (n)
  • 72.54 (a)
Gpr156 16
Gpr156 36
  • 70 (a)
(Pan troglodytes)
Mammalia GPR156 35
  • 99.51 (n)
  • 99.14 (a)
GPR156 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Gpr156 35
  • 78.62 (n)
  • 73.05 (a)
(Monodelphis domestica)
Mammalia GPR156 36
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia GPR156 36
  • 62 (a)
(Gallus gallus)
Aves GPR156 35
  • 60.41 (n)
  • 52.63 (a)
GPR156 36
  • 44 (a)
(Anolis carolinensis)
Reptilia GPR156 36
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr156 35
  • 52.35 (n)
  • 42.55 (a)
(Danio rerio)
Actinopterygii LOC101885196 35
  • 50.77 (n)
  • 42.36 (a)
GPR156 36
  • 33 (a)
fruit fly
(Drosophila melanogaster)
Insecta GABA-B-R3 36
  • 10 (a)
Species with no ortholog for GPR156:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR156 Gene

Gene Tree for GPR156 (if available)
Gene Tree for GPR156 (if available)

Paralogs for GPR156 Gene

Paralogs for GPR156 Gene

genes like me logo Genes that share paralogs with GPR156: view

Variants for GPR156 Gene

Sequence variations from dbSNP and Humsavar for GPR156 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_049284 -
rs1085611 -- 120,269,089(+) atgcc(C/T)agcta intron-variant
rs1873651 -- 120,248,511(+) tattt(A/T)ttttt intron-variant
rs1873652 -- 120,265,238(+) CTACT(A/G)CCTTA intron-variant
rs1873653 -- 120,265,613(+) TAGAC(A/G)GAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR156 Gene

Variant ID Type Subtype PubMed ID
nsv829697 CNV Loss 17160897
nsv877376 CNV Gain 21882294
nsv3967 CNV Loss 18451855
esv2596469 CNV Deletion 19546169
nsv513068 CNV Loss 21212237
nsv518052 CNV Loss 19592680
esv2257745 CNV Deletion 18987734
esv4361 CNV Deletion 18987735
esv7231 CNV Loss 19470904
esv2725828 CNV Deletion 23290073
dgv125n6 CNV Loss 16902084
esv998169 CNV Deletion 20482838
esv1045898 CNV Deletion 17803354
esv1006353 CNV Deletion 20482838
esv1543050 CNV Insertion 17803354
esv259525 OTHER Complex 20981092
esv259822 OTHER Complex 20981092
esv6870 CNV Gain 19470904
esv1439832 CNV Insertion 17803354
nsv829698 CNV Gain 17160897

Variation tolerance for GPR156 Gene

Residual Variation Intolerance Score: 88.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.12; 61.31% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GPR156 Gene

Disorders for GPR156 Gene

Relevant External Links for GPR156

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GPR156 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR156 Gene

Publications for GPR156 Gene

  1. Molecular cloning and characterization of a novel GABA(B)-related G- protein coupled receptor. (PMID: 12591167) Calver A.R. … Pangalos M.N. (Brain Res. Mol. Brain Res. 2003) 2 3 4 23 67
  2. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3
  3. Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes. (PMID: 15203218) Fu G.K. … Stuve L.L. (Genomics 2004) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  5. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis D.K. … Gaitanaris G.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3

Products for GPR156 Gene

Sources for GPR156 Gene