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Aliases for GPR153 Gene

Aliases for GPR153 Gene

  • G Protein-Coupled Receptor 153 2 3 5
  • G-Protein Coupled Receptor PGR1 3 4
  • PGR1 3 4
  • Probable G-Protein Coupled Receptor 153 3

External Ids for GPR153 Gene

Previous GeneCards Identifiers for GPR153 Gene

  • GC01U900256
  • GC01M006019
  • GC01M006243
  • GC01M005456

Summaries for GPR153 Gene

GeneCards Summary for GPR153 Gene

GPR153 (G Protein-Coupled Receptor 153) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR162.

UniProtKB/Swiss-Prot for GPR153 Gene

  • Orphan receptor.

Gene Wiki entry for GPR153 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR153 Gene

Genomics for GPR153 Gene

Regulatory Elements for GPR153 Gene

Enhancers for GPR153 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F006259 1.5 FANTOM5 Ensembl ENCODE 22.9 -1.0 -1009 4.6 PKNOX1 ATF1 CREB3L1 ARID4B SIN3A BRCA1 GLIS2 KLF7 ZNF263 SP3 GPR153 ICMT LINC00337 RPL22 CHD5 RNF207 LOC102724450 THAP3 GC01P006262 ENSG00000271746
GH01F006257 0.5 ENCODE 21.4 +3.3 3255 0.2 FOSL1 ARID1B FOS ZIC2 GPR153 HES3
GH01F006256 0.4 ENCODE 20.4 +4.2 4155 0.2 KLF1 PKNOX1 RNF2 E2F5 CEBPB KLF17 ZNF121 ZFP3 GATA2 GPR153 HES3
GH01F006247 0.8 ENCODE 15 +15.3 15252 1.9 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143 ZNF263 SP3 GPR153 HES3
GH01F006238 1 Ensembl ENCODE 11.3 +20.6 20609 4.7 ARID4B RAD21 RARA ZNF121 HMG20B SP3 CBFB CEBPB REST SMARCA4 GPR153 LINC00337 ICMT HES3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GPR153 on UCSC Golden Path with GeneCards custom track

Promoters for GPR153 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000529678 190 2001 PKNOX1 ATF1 CREB3L1 BRCA1 GLIS2 KLF7 ZNF263 SP3 SP5 NFYC

Genomic Location for GPR153 Gene

Chromosome:
1
Start:
6,247,346 bp from pter
End:
6,260,990 bp from pter
Size:
13,645 bases
Orientation:
Minus strand

Genomic View for GPR153 Gene

Genes around GPR153 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR153 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR153 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR153 Gene

Proteins for GPR153 Gene

  • Protein details for GPR153 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NV75-GP153_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 153
    Protein Accession:
    Q6NV75
    Secondary Accessions:
    • Q5TGR5
    • Q6AHW8
    • Q86SP8

    Protein attributes for GPR153 Gene

    Size:
    609 amino acids
    Molecular mass:
    65361 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI19434.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for GPR153 Gene

Post-translational modifications for GPR153 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPR153 Gene

No data available for DME Specific Peptides for GPR153 Gene

Domains & Families for GPR153 Gene

Gene Families for GPR153 Gene

Protein Domains for GPR153 Gene

Suggested Antigen Peptide Sequences for GPR153 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6NV75

UniProtKB/Swiss-Prot:

GP153_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR153: view

Function for GPR153 Gene

Molecular function for GPR153 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Gene Ontology (GO) - Molecular Function for GPR153 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GPR153: view
genes like me logo Genes that share phenotypes with GPR153: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR153

miRNA for GPR153 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR153 Gene

Localization for GPR153 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR153 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR153 Gene COMPARTMENTS Subcellular localization image for GPR153 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR153 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR153: view

Pathways & Interactions for GPR153 Gene

SuperPathways for GPR153 Gene

No Data Available

Interacting Proteins for GPR153 Gene

Gene Ontology (GO) - Biological Process for GPR153 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR153: view

No data available for Pathways by source and SIGNOR curated interactions for GPR153 Gene

Transcripts for GPR153 Gene

mRNA/cDNA for GPR153 Gene

Unigene Clusters for GPR153 Gene

G protein-coupled receptor 153:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR153 Gene

No ASD Table

Relevant External Links for GPR153 Gene

GeneLoc Exon Structure for
GPR153
ECgene alternative splicing isoforms for
GPR153

Expression for GPR153 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR153 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GPR153 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR153 Gene



Protein tissue co-expression partners for GPR153 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPR153 Gene:

GPR153

SOURCE GeneReport for Unigene cluster for GPR153 Gene:

Hs.531581
genes like me logo Genes that share expression patterns with GPR153: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GPR153 Gene

Orthologs for GPR153 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR153 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR153 34 35
  • 99.07 (n)
cow
(Bos Taurus)
Mammalia GPR153 34 35
  • 87.99 (n)
dog
(Canis familiaris)
Mammalia GPR153 34 35
  • 87.99 (n)
mouse
(Mus musculus)
Mammalia Gpr153 34 16 35
  • 84.51 (n)
rat
(Rattus norvegicus)
Mammalia Gpr153 34
  • 80.86 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR153 35
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR153 35
  • 40 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR153 34
  • 72.34 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr153 34
  • 61.15 (n)
zebrafish
(Danio rerio)
Actinopterygii gpr153 35
  • 75 (a)
OneToMany
LOC101883998 34
  • 74.47 (n)
GPR153 (2 of 2) 35
  • 39 (a)
OneToMany
Species where no ortholog for GPR153 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR153 Gene

ENSEMBL:
Gene Tree for GPR153 (if available)
TreeFam:
Gene Tree for GPR153 (if available)

Paralogs for GPR153 Gene

Paralogs for GPR153 Gene

(2) SIMAP similar genes for GPR153 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPR153: view

Variants for GPR153 Gene

Sequence variations from dbSNP and Humsavar for GPR153 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs776061422 Likely pathogenic 6,254,689(+) GGGGC(A/G)CTGCC reference, missense
rs1043971 -- 6,247,570(-) TCCTG(C/T)GGTTT utr-variant-3-prime
rs1062750 -- 6,248,129(-) TAACC(C/T)TGAGC utr-variant-3-prime
rs1075676 -- 6,250,074(-) TCCCC(A/G)GGGTG intron-variant, utr-variant-3-prime
rs1075751 -- 6,249,257(+) CGCGG(G/T)GGGGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GPR153 Gene

Variant ID Type Subtype PubMed ID
dgv8n67 CNV gain 20364138
nsv1076029 CNV deletion 25765185
nsv508825 CNV insertion 20534489
nsv526371 CNV loss 19592680
nsv545236 CNV loss 21841781
nsv545237 CNV loss 21841781
nsv545238 CNV loss 21841781
nsv831425 CNV loss 17160897
nsv965 CNV deletion 18451855

Variation tolerance for GPR153 Gene

Residual Variation Intolerance Score: 66.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.26; 70.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR153 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR153

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR153 Gene

Disorders for GPR153 Gene

Relevant External Links for GPR153

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR153

No disorders were found for GPR153 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR153 Gene

Publications for GPR153 Gene

  1. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis D.K. … Gaitanaris G.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Exome sequencing supports a de novo mutational paradigm for schizophrenia. (PMID: 21822266) Xu B. … Karayiorgou M. (Nat. Genet. 2011) 3 64
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64

Products for GPR153 Gene

Sources for GPR153 Gene

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