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Aliases for GPR153 Gene

Aliases for GPR153 Gene

  • G Protein-Coupled Receptor 153 2 3 5
  • G-Protein Coupled Receptor PGR1 3 4
  • PGR1 3 4

External Ids for GPR153 Gene

Previous GeneCards Identifiers for GPR153 Gene

  • GC01U900256
  • GC01M006019
  • GC01M006243
  • GC01M005456

Summaries for GPR153 Gene

GeneCards Summary for GPR153 Gene

GPR153 (G Protein-Coupled Receptor 153) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR162.

UniProtKB/Swiss-Prot for GPR153 Gene

  • Orphan receptor.

Gene Wiki entry for GPR153 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR153 Gene

Genomics for GPR153 Gene

Regulatory Elements for GPR153 Gene

Enhancers for GPR153 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPR153 on UCSC Golden Path with GeneCards custom track

Promoters for GPR153 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPR153 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR153 Gene

6,247,346 bp from pter
6,260,990 bp from pter
13,645 bases
Minus strand

Genomic View for GPR153 Gene

Genes around GPR153 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR153 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR153 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR153 Gene

Proteins for GPR153 Gene

  • Protein details for GPR153 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 153
    Protein Accession:
    Secondary Accessions:
    • Q5TGR5
    • Q6AHW8
    • Q86SP8

    Protein attributes for GPR153 Gene

    609 amino acids
    Molecular mass:
    65361 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAI19434.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for GPR153 Gene

Proteomics data for GPR153 Gene at MOPED

Post-translational modifications for GPR153 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPR153 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR153 Gene

Domains & Families for GPR153 Gene

Gene Families for GPR153 Gene

Protein Domains for GPR153 Gene

Suggested Antigen Peptide Sequences for GPR153 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR153: view

Function for GPR153 Gene

Molecular function for GPR153 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.
genes like me logo Genes that share phenotypes with GPR153: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR153

miRNA for GPR153 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR153 Gene

Localization for GPR153 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR153 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GPR153 Gene COMPARTMENTS Subcellular localization image for GPR153 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR153 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with GPR153: view

Pathways & Interactions for GPR153 Gene

SuperPathways for GPR153 Gene

No Data Available

Interacting Proteins for GPR153 Gene

Gene Ontology (GO) - Biological Process for GPR153 Gene


No data available for Pathways by source and SIGNOR curated interactions for GPR153 Gene

Drugs & Compounds for GPR153 Gene

No Compound Related Data Available

Transcripts for GPR153 Gene

mRNA/cDNA for GPR153 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(84) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR153 Gene

G protein-coupled receptor 153:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR153 Gene

No ASD Table

Relevant External Links for GPR153 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR153 Gene

mRNA expression in normal human tissues for GPR153 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GPR153 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR153 Gene

SOURCE GeneReport for Unigene cluster for GPR153 Gene Hs.531581

genes like me logo Genes that share expression patterns with GPR153: view

Protein tissue co-expression partners for GPR153 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GPR153 Gene

Orthologs for GPR153 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR153 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPR153 35
  • 87.99 (n)
  • 88.76 (a)
GPR153 36
  • 85 (a)
(Canis familiaris)
Mammalia GPR153 35
  • 87.99 (n)
  • 87.82 (a)
GPR153 36
  • 62 (a)
(Mus musculus)
Mammalia Gpr153 35
  • 84.51 (n)
  • 87.64 (a)
Gpr153 16
Gpr153 36
  • 83 (a)
(Pan troglodytes)
Mammalia GPR153 35
  • 99.07 (n)
  • 98.52 (a)
GPR153 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Gpr153 35
  • 80.86 (n)
  • 82.2 (a)
(Monodelphis domestica)
Mammalia GPR153 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia GPR153 36
  • 40 (a)
(Gallus gallus)
Aves GPR153 35
  • 72.34 (n)
  • 65.3 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr153 35
  • 61.15 (n)
  • 62.42 (a)
(Danio rerio)
Actinopterygii LOC101883998 35
  • 74.47 (n)
  • 76.98 (a)
gpr153 36
  • 75 (a)
GPR153 (2 of 2) 36
  • 39 (a)
Species with no ortholog for GPR153:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR153 Gene

Gene Tree for GPR153 (if available)
Gene Tree for GPR153 (if available)

Paralogs for GPR153 Gene

Paralogs for GPR153 Gene

(2) SIMAP similar genes for GPR153 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPR153: view

Variants for GPR153 Gene

Sequence variations from dbSNP and Humsavar for GPR153 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs12735670 - 6,253,878(+) CGCGG(C/T)GGTCG reference, missense
rs746765 -- 6,249,794(-) GCCGA(A/G)AGCCT reference, synonymous-codon
rs846113 -- 6,258,531(-) GGCTA(C/G)TCTGC intron-variant
rs1043971 -- 6,247,570(-) TCCTG(C/T)GGTTT utr-variant-3-prime
rs1062750 -- 6,248,129(-) TAACC(C/T)TGAGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GPR153 Gene

Variant ID Type Subtype PubMed ID
nsv871698 CNV Loss 21882294
nsv870945 CNV Loss 21882294
dgv119n71 CNV Loss 21882294
nsv831425 CNV Loss 17160897
dgv120n71 CNV Loss 21882294
dgv121n71 CNV Loss 21882294
dgv8n67 CNV Gain 20364138
nsv508825 CNV Insertion 20534489
nsv871569 CNV Loss 21882294
dgv122n71 CNV Loss 21882294
dgv123n71 CNV Loss 21882294
nsv871385 CNV Loss 21882294
nsv871646 CNV Loss 21882294
dgv124n71 CNV Loss 21882294
nsv871266 CNV Loss 21882294
nsv526371 CNV Loss 19592680
nsv871324 CNV Loss 21882294
nsv871592 CNV Loss 21882294
nsv965 CNV Loss 18451855
nsv871117 CNV Loss 21882294

Variation tolerance for GPR153 Gene

Residual Variation Intolerance Score: 66.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.26; 70.24% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GPR153 Gene

Disorders for GPR153 Gene

Relevant External Links for GPR153

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GPR153 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR153 Gene

Publications for GPR153 Gene

  1. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis D.K. … Gaitanaris G.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4 67
  2. Exome sequencing supports a de novo mutational paradigm for schizophrenia. (PMID: 21822266) Xu B. … Karayiorgou M. (Nat. Genet. 2011) 3
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3
  4. Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship. (PMID: 15777626) Gloriam D.E. … Fredriksson R. (Biochim. Biophys. Acta 2005) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for GPR153 Gene

Sources for GPR153 Gene