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Aliases for GPR152 Gene

Aliases for GPR152 Gene

  • G Protein-Coupled Receptor 152 2 3 5
  • PGR5 3 4
  • Probable G-Protein Coupled Receptor 152 3
  • G Protein-Coupled Receptor PGR5 3
  • G-Protein Coupled Receptor PGR5 4

External Ids for GPR152 Gene

Previous GeneCards Identifiers for GPR152 Gene

  • GC00U914420
  • GC11M066995
  • GC11M066975
  • GC11M067218
  • GC11M063548

Summaries for GPR152 Gene

GeneCards Summary for GPR152 Gene

GPR152 (G Protein-Coupled Receptor 152) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is PTGDR2.

UniProtKB/Swiss-Prot for GPR152 Gene

  • Orphan receptor.

Gene Wiki entry for GPR152 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR152 Gene

Genomics for GPR152 Gene

Regulatory Elements for GPR152 Gene

Enhancers for GPR152 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F067458 1 Ensembl ENCODE 0.4 -7.1 -7117 2.0 CTCF PKNOX1 MXI1 MTA2 TRIM22 BMI1 TBX21 ZBTB40 POLR2A IKZF1 PTPRCAP CARNS1 GC11P067462 GPR152
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPR152 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR152 Gene

67,451,301 bp from pter
67,452,729 bp from pter
1,429 bases
Minus strand

Genomic View for GPR152 Gene

Genes around GPR152 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR152 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR152 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR152 Gene

Proteins for GPR152 Gene

  • Protein details for GPR152 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 152
    Protein Accession:
    Secondary Accessions:
    • Q0VD88
    • Q86SM0

    Protein attributes for GPR152 Gene

    470 amino acids
    Molecular mass:
    50962 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR152 Gene

Post-translational modifications for GPR152 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPR152 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR152 Gene

Domains & Families for GPR152 Gene

Gene Families for GPR152 Gene

Protein Domains for GPR152 Gene

Suggested Antigen Peptide Sequences for GPR152 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR152: view

Function for GPR152 Gene

Molecular function for GPR152 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Gene Ontology (GO) - Molecular Function for GPR152 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001595 angiotensin receptor activity IBA --
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GPR152: view
genes like me logo Genes that share phenotypes with GPR152: view

Animal Models for GPR152 Gene

MGI Knock Outs for GPR152:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR152

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GPR152 Gene

Localization for GPR152 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR152 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR152 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR152 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR152: view

Pathways & Interactions for GPR152 Gene

SuperPathways for GPR152 Gene

No Data Available

Interacting Proteins for GPR152 Gene

Gene Ontology (GO) - Biological Process for GPR152 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0038166 angiotensin-activated signaling pathway IBA --
genes like me logo Genes that share ontologies with GPR152: view

No data available for Pathways by source and SIGNOR curated interactions for GPR152 Gene

Transcripts for GPR152 Gene

mRNA/cDNA for GPR152 Gene

(1) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR152 Gene

No ASD Table

Relevant External Links for GPR152 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR152 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR152 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of GPR152 Gene:


SOURCE GeneReport for Unigene cluster for GPR152 Gene:

genes like me logo Genes that share expression patterns with GPR152: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for GPR152 Gene

Orthologs for GPR152 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR152 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR152 34
  • 99.15 (n)
(Bos Taurus)
Mammalia GPR152 34 35
  • 85.43 (n)
(Canis familiaris)
Mammalia GPR152 34 35
  • 84.05 (n)
(Mus musculus)
Mammalia Gpr152 34 16 35
  • 78.79 (n)
(Rattus norvegicus)
Mammalia Gpr152 34
  • 78.58 (n)
(Monodelphis domestica)
Mammalia GPR152 35
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 19 (a)
(Danio rerio)
Actinopterygii CU571081.1 35
  • 18 (a)
Species where no ortholog for GPR152 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR152 Gene

Gene Tree for GPR152 (if available)
Gene Tree for GPR152 (if available)

Paralogs for GPR152 Gene

Paralogs for GPR152 Gene

genes like me logo Genes that share paralogs with GPR152: view

Variants for GPR152 Gene

Sequence variations from dbSNP and Humsavar for GPR152 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs111808036 -- 67,453,333(+) GGGTC(C/T)GGATA intron-variant, upstream-variant-2KB
rs11227796 -- 67,453,198(+) TCACT(A/G)TGTTG intron-variant, upstream-variant-2KB
rs112750105 -- 67,453,221(+) TTGAA(C/G)TCGTG intron-variant, upstream-variant-2KB
rs112763994 -- 67,451,106(+) TGGCC(A/G)GGAGC downstream-variant-500B, upstream-variant-2KB
rs113329646 -- 67,452,572(+) AGCCA(C/T)GCCAT upstream-variant-2KB, reference, synonymous-codon, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for GPR152 Gene

Variant ID Type Subtype PubMed ID
dgv1977n54 CNV loss 21841781
dgv52n111 CNV deletion 26073780
nsv468604 CNV loss 19166990
nsv521723 CNV loss 19592680
nsv524096 CNV loss 19592680
nsv527056 CNV loss 19592680

Variation tolerance for GPR152 Gene

Residual Variation Intolerance Score: 47.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.30; 62.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR152 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR152 Gene

Disorders for GPR152 Gene

Relevant External Links for GPR152

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GPR152 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR152 Gene

Publications for GPR152 Gene

  1. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis D.K. … Gaitanaris G.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S. … Mitaku S. (FEBS Lett. 2002) 3 4 64
  4. Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship. (PMID: 15777626) Gloriam D.E. … Fredriksson R. (Biochim. Biophys. Acta 2005) 3 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for GPR152 Gene

Sources for GPR152 Gene

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