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GPR151 Gene

protein-coding   GIFtS: 45
GCID: GC05M145874

G Protein-Coupled Receptor 151

  Search for GPR151
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
G Protein-Coupled Receptor 1511 2     GALR42
Galanin Receptor 41 2     GALRL2
GPCR-20372 3     GPCR2
PGR72 3     Probable G-Protein Coupled Receptor 1512
G-Protein Coupled Receptor PGR72 3     Putative G-Protein Coupled Receptor2

External Ids:    HGNC: 236241   Entrez Gene: 1343912   Ensembl: ENSG000001732507   UniProtKB: Q8TDV03   

Export aliases for GPR151 gene to outside databases

Previous GC identifers: GC05M145922 GC05M141041


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for GPR151 Gene:
GPR151 (G protein-coupled receptor 151) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity.

UniProtKB/Swiss-Prot: GP151_HUMAN, Q8TDV0
Function: Orphan receptor

Gene Wiki entry for GPR151 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_029289.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the GPR151 gene promoter:
         TBP   NF-1   FOXD1   Nkx2-5   POU3F2   E47   HOXA5   Hand1   ATF6   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPR151 promoter sequence
   Search Chromatin IP Primers for GPR151

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GPR151


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q32   Ensembl cytogenetic band:  5q32   HGNC cytogenetic band: 5q32

GPR151 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPR151 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M145874:  view genomic region     (about GC identifiers)

Start:
145,892,666 bp from pter      End:
145,895,753 bp from pter
Size:
3,088 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GP151_HUMAN, Q8TDV0 (See protein sequence)
Recommended Name: Probable G-protein coupled receptor 151  
Size: 419 amino acids; 46637 Da
Sequence caution: Sequence=BAC05899.1; Type=Erroneous initiation;
Secondary accessions: Q86SN8 Q8NGV2

Explore the universe of human proteins at neXtProt for GPR151: NX_Q8TDV0

Explore proteomics data for GPR151 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn10, Asn15

  • See GPR151 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_919227.2  
    ENSEMBL proteins: 
     ENSP00000308733  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GPCRAO: GPCR / Class A : Orphans

    IUPHAR Guide to PHARMACOLOGY protein family classification: GPR151
    Class A Orphans

    2 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8TDV0

    ProtoNet protein and cluster: Q8TDV0

    UniProtKB/Swiss-Prot: GP151_HUMAN, Q8TDV0
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with GPR151           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GP151_HUMAN, Q8TDV0
    Function: Orphan receptor

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
         
    Find genes that share ontologies with GPR151           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GPR151:
     Increased G2M DNA content 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Gpr151):
     normal 

    Find genes that share phenotypes with GPR151           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GPR151
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GP151_HUMAN, Q8TDV0: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    chloroplast2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with GPR151           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including GPR151: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GPR151

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for GPR151 (Q8TDV03 ENSP000003087334) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GALP224663, ENSP000002656434I2D: score=1 STRING: ENSP00000265643
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with GPR151           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GPR151 (GP151)

    1 Novoseek inferred chemical compound relationship for GPR151 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dopamine 0 1 11690637 (1)



    Find genes that share compounds with GPR151           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GPR151 gene: 
    NM_194251.2  

    Unigene Cluster for GPR151:

    G protein-coupled receptor 151
    Hs.483732  [show with all ESTs]
    Unigene Representative Sequence: AY351676
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000311104(uc003lod.1)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat GPR151
      QuantiFast Probe-based Assays in human, mouse, rat GPR151

    Additional mRNA sequence: 

    AY255557.1 AY351676.1 

    1 DOTS entry:

    DT.100654705 

    4 AceView cDNA sequences:

    AY351676 AY255557 NM_194251 AK122627 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GPR151 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GPR151 Expression
    About this image


    GPR151 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 17 entries
             Thalamus
             Septum   
    GPR151 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GPR151 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.483732
        Pathway & Disease-focused RT2 Profiler PCR Array including GPR151: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR151

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for GPR151 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpr1511 , 5 G protein-coupled receptor 1511, 5 82.69(n)1
    78.26(a)1
      18 (22.71 cM)5
    2402391  NM_181543.11  NP_853521.11 
     425780205 
    lizard
    (Anolis carolinensis)
    Reptilia GPR1516
    G protein-coupled receptor 151
    59(a)
    1 ↔ 1
    GL343234.1(427041-428279)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia gpr1511 G protein-coupled receptor 151 60.54(n)
    52.7(a)
      100486417  XM_002935277.2  XP_002935323.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005380821 probable G-protein coupled receptor 151-like 54.44(n)
    44.99(a)
      100538082  XM_003199978.2  XP_003200026.1 


    ENSEMBL Gene Tree for GPR151 (if available)
    TreeFam Gene Tree for GPR151 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GPR151 (see all 116)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1835835911,2
    --145893942(+) TTAATA/GTGTTA 1 -- ds50010--------
    rs1886291471,2
    --145894050(+) AAAGGA/GGCTCA 1 -- ds50010--------
    rs1483310221,2
    --145894292(+) TGTAGA/TTTGTG 1 -- ds50010--------
    rs1414839611,2
    --145894325(+) GGTAAC/TAATTA 1 -- ds50010--------
    rs1928066621,2
    --145894335(+) ATATCA/GGTTTG 1 -- ds50010--------
    rs1508206981,2
    C--145894432(+) CCTTCC/TCCTGT 2 G syn10--------
    rs1397792921,2
    F--145894462(+) CAGGGG/TATAGG 2 I syn11Minor allele frequency- T:0.00NA 4548
    rs1429719951,2
    C,F--145894493(+) GGACTG/CTGTCC 2 /T /R mis11Minor allele frequency- C:0.00NA 4550
    rs2014370881,2
    C--145894518(+) CTGCTC/GTACGT 2 Q E mis10--------
    rs1392765211,2
    C,F--145894522(+) TCTACG/ATCAGG 2 /D syn12Minor allele frequency- A:0.00NA EU 5873

    HapMap Linkage Disequilibrium report for GPR151 (145892666 - 145895753 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for GPR151: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GPR151
    DNA2.0 Custom Variant and Variant Library Synthesis for GPR151

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with GPR151           About GenesLikeMe

    Genetic Association Database (GAD): GPR151

    Export disorders for GPR151 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GPR151 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with GPR151)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The G protein-coupled receptor repertoires of human and mouse. (PubMed id 12679517)1, 2, 3 Vassilatis D.K.... Gaitanaris G.A. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    2. Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878)1, 2 Takeda S.... Mitaku S. (FEBS Lett. 2002)
    3. Cloning and characterization of a novel G-protein-coupled receptor with homology to galanin receptors. (PubMed id 15111018)1 Ignatov A....Schaller H.C. (Neuropharmacology 2004)
    4. (PubMed id )2 
    5. Activation of calcitonin receptor and calcitonin receptor-like receptor by membrane-anchored ligands. (PubMed id 19903822)9 Chang C.L....Hsu S.Y. (J. Biol. Chem. 2010)
    6. Isolation and chromosomal localization of GPR31, a human gene encoding a putative G protein-coupled receptor. (PubMed id 9205127)9 Zingoni A....Napolitano M. (Genomics 1997)
    7. Structure-function relationships of the N-terminus of receptor activity-modifying proteins. (PubMed id 20015292)9 Qi T. and Hay D.L. (Br. J. Pharmacol. 2010)
    8. In silico investigation of intronless Rhodopsin-like G-protein coupled receptors (GPCR) in the human genome: features and classification. (PubMed id 19388584)9 Alem K....RebaA^ A. (Arch Inst Pasteur Tunis 2007)
    9. Signaling through a G Protein-coupled receptor and its corresponding G protein follows a stoichiometrically limited model. (PubMed id 17420253)9 Philip F....Scarlata S. (J. Biol. Chem. 2007)
    10. Purinergic-receptor oligomerization: implications for neural functions in the central nervous system. (PubMed id 15545012)9 Nakata H....Kamiya T. (Neurotox Res 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 134391 HGNC: 23624 AceView: GPR151 Ensembl:ENSG00000173250 euGenes: HUgn134391
    ECgene: GPR151 H-InvDB: GPR151

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GPR151 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GPR151 gene:
    Search GeneIP for patents involving GPR151

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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