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GPR151 Gene(Protein Coding)

G Protein-Coupled Receptor 151

GCID:
GC05M146513
GIFtS:
46
Genes Participants
UDN Logo

Aliases for GPR151 Gene

Aliases for GPR151 Gene

  • G Protein-Coupled Receptor 151 2 3 5
  • G-Protein Coupled Receptor PGR7 3 4
  • Galanin Receptor 4 2 3
  • GPCR-2037 3 4
  • PGR7 3 4
  • Probable G-Protein Coupled Receptor 151 3
  • Putative G-Protein Coupled Receptor 3
  • GALR4 3
  • GALRL 3
  • GPCR 3

External Ids for GPR151 Gene

Previous GeneCards Identifiers for GPR151 Gene

  • GC05M145922
  • GC05M145874
  • GC05M141041

Summaries for GPR151 Gene

GeneCards Summary for GPR151 Gene

GPR151 (G Protein-Coupled Receptor 151) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity.

UniProtKB/Swiss-Prot for GPR151 Gene

  • Orphan receptor.

Gene Wiki entry for GPR151 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR151 Gene

Genomics for GPR151 Gene

Products:

  1. Regulatory Element

Regulatory Elements for GPR151 Gene

Enhancers for GPR151 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F146446 1.4 FANTOM5 ENCODE 11 +68.4 68364 2.5 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 RBM27 GPR151 TCERG1 ENSG00000277568
GH05F146452 0.4 Ensembl 11 +63.5 63490 0.2 SCRT2 GPR151 TCERG1 ENSG00000277568
GH05F146637 0.4 FANTOM5 5.1 -121.6 -121641 0.0 ZNF263 GPR151 PPP2R2B RN7SL791P RNA5SP196
GH05F146344 0.8 FANTOM5 ENCODE 2.5 +171.3 171265 0.3 RNF2 SUZ12 CBX2 ENSG00000250025 GRXCR2 GPR151 GC05P146343 GC05P146357
GH05F146192 0.8 FANTOM5 2.1 +323.1 323131 0.3 ZSCAN18 BACH1 IRF9 ZNF324 PRDM10 TRIM24 RNF2 ZNF740 NR2F1 CEBPB LARS GRXCR2 GPR151 ENSG00000275740 RBM27
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPR151 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the GPR151 gene promoter:

Genomic Location for GPR151 Gene

Chromosome:
5
Start:
146,513,103 bp from pter
End:
146,516,190 bp from pter
Size:
3,088 bases
Orientation:
Minus strand

Genomic View for GPR151 Gene

Genes around GPR151 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR151 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR151 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GPR151 Gene

Proteins for GPR151 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for GPR151 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDV0-GP151_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 151
    Protein Accession:
    Q8TDV0
    Secondary Accessions:
    • Q86SN8
    • Q8NGV2

    Protein attributes for GPR151 Gene

    Size:
    419 amino acids
    Molecular mass:
    46637 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05899.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GPR151 Gene

Post-translational modifications for GPR151 Gene

  • Glycosylation at Asn 10 and Asn 15
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR151 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR151 Gene

Domains & Families for GPR151 Gene

Gene Families for GPR151 Gene

HGNC:
IUPHAR :

Protein Domains for GPR151 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR151 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TDV0

UniProtKB/Swiss-Prot:

GP151_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR151: view

Function for GPR151 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for GPR151 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Gene Ontology (GO) - Molecular Function for GPR151 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GPR151: view
genes like me logo Genes that share phenotypes with GPR151: view

Animal Models for GPR151 Gene

MGI Knock Outs for GPR151:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR151

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR151 Gene

Localization for GPR151 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR151 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR151 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR151 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR151: view

Pathways & Interactions for GPR151 Gene

SuperPathways for GPR151 Gene

PathCards logo More details on SuperPathways for GPR151
No Data Available

Gene Ontology (GO) - Biological Process for GPR151 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR151: view

No data available for Pathways by source and SIGNOR curated interactions for GPR151 Gene

Drugs & Compounds for GPR151 Gene

Products:

  1. Drug

(1) Drugs for GPR151 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with GPR151: view

Transcripts for GPR151 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for GPR151 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR151 Gene

G protein-coupled receptor 151:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR151 Gene

No ASD Table

Relevant External Links for GPR151 Gene

GeneLoc Exon Structure for
GPR151
ECgene alternative splicing isoforms for
GPR151

Expression for GPR151 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR151 Gene

mRNA expression in normal human tissues for GPR151 Gene
mRNA expression by BioGPS for GPR151 GenemRNA expression by GTEx for GPR151 Gene

mRNA differential expression in normal tissues according to GTEx for GPR151 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.7), Brain - Anterior cingulate cortex (BA24) (x6.4), Brain - Frontal Cortex (BA9) (x6.2), Brain - Cortex (x4.6), and Brain - Substantia nigra (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of GPR151 Gene:

GPR151

SOURCE GeneReport for Unigene cluster for GPR151 Gene:

Hs.483732
genes like me logo Genes that share expression patterns with GPR151: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for GPR151 Gene

Orthologs for GPR151 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR151 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia GPR151 34 35
  • 99.52 (n)
cow
(Bos Taurus)
 Mammalia GPR151 34 35
  • 88.59 (n)
dog
(Canis familiaris)
 Mammalia GPR151 34 35
  • 86.99 (n)
rat
(Rattus norvegicus)
 Mammalia Gpr151 34
  • 83.45 (n)
mouse
(Mus musculus)
 Mammalia Gpr151 34 16 35
  • 82.69 (n)
oppossum
(Monodelphis domestica)
 Mammalia GPR151 35
  • 72 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia GPR151 35
  • 63 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia GPR151 35
  • 59 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia gpr151 34
  • 60.54 (n)
zebrafish
(Danio rerio)
 Actinopterygii LOC100538082 34
  • 54.44 (n)
GPR151 35
  • 28 (a)
 OneToOne
Species where no ortholog for GPR151 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR151 Gene

ENSEMBL:
Gene Tree for GPR151 (if available)
TreeFam:
Gene Tree for GPR151 (if available)

Paralogs for GPR151 Gene

No data available for Paralogs for GPR151 Gene

Variants for GPR151 Gene

Sequence variations from dbSNP and Humsavar for GPR151 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10062873 -- 146,516,774(+) GTTCC(A/C)TCAAC upstream-variant-2KB
rs111754680 -- 146,515,601(+) CATTC(C/T)GGCAG reference, synonymous-codon
rs112425963 -- 146,517,260(+) AAAAG(-/A)AAAAA upstream-variant-2KB
rs113109472 -- 146,517,759(+) CAGTG(A/G)TGCTG upstream-variant-2KB
rs113827596 -- 146,514,510(+) CCTCT(A/G)CTGCA downstream-variant-500B

Variation tolerance for GPR151 Gene

Residual Variation Intolerance Score: 96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.28; 70.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR151 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR151

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GPR151 Gene

Disorders for GPR151 Gene

Relevant External Links for GPR151

Genetic Association Database (GAD)
GPR151
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR151

No disorders were found for GPR151 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR151 Gene

Publications for GPR151 Gene

  1. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis D.K. … Gaitanaris G.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4 64
  2. Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S. … Mitaku S. (FEBS Lett. 2002) 3 4 64
  3. Structure-function relationships of the N-terminus of receptor activity-modifying proteins. (PMID: 20015292) Qi T. … Hay D.L. (Br. J. Pharmacol. 2010) 22 64
  4. Functional characterization of two human receptor activity-modifying protein 3 variants. (PMID: 20034525) Bailey R.J. … Hay D.L. (Peptides 2010) 22 64
  5. Activation of calcitonin receptor and calcitonin receptor-like receptor by membrane-anchored ligands. (PMID: 19903822) Chang C.L. … Hsu S.Y. (J. Biol. Chem. 2010) 22 64

Products for GPR151 Gene

Sources for GPR151 Gene

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