Aliases for GPR151 Gene
Aliases for GPR151 Gene
External Ids for GPR151 Gene
- HGNC: 23624
- Entrez Gene: 134391
- Ensembl: ENSG00000173250
- UniProtKB: Q8TDV0
Previous GeneCards Identifiers for GPR151 Gene
- GC05M145922
- GC05M145874
- GC05M141041
Summaries for GPR151 Gene
-
The protein encoded by this gene is similar to the galanin receptor subfamily of G protein-coupled receptors. The encoded protein is found predominantly in the central nervous system. [provided by RefSeq, Feb 2017]
GeneCards Summary for GPR151 Gene
GPR151 (G Protein-Coupled Receptor 151) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity.
UniProtKB/Swiss-Prot for GPR151 Gene
-
Orphan receptor.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR151 Gene
Genomics for GPR151 Gene
Regulatory Elements for GPR151 Gene
Enhancers for GPR151 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH05G146446 | 1.4 | FANTOM5 ENCODE | 11 | +68.4 | 68364 | 2.5 | HDGF PKNOX1 MLX CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A DMAP1 | RBM27 GPR151 TCERG1 ENSG00000277568 |
| GH05G146450 | 0.8 | Ensembl | 11 | +65.9 | 65890 | 0.2 | PKNOX1 FOXA2 FEZF1 ZKSCAN1 ZNF664 HIC1 GATA3 ZNF366 GLI2 NFIA | GPR151 TCERG1 ENSG00000277568 |
| GH05G146451 | 0.6 | Ensembl | 11 | +64.5 | 64490 | 0.6 | SCRT1 CTCF ZNF580 ZEB2 CREM RAD21 ZNF18 | GPR151 TCERG1 ENSG00000277568 |
| GH05G146637 | 0.4 | FANTOM5 | 5.1 | -121.6 | -121641 | 0.0 | ZNF263 | GPR151 PPP2R2B RN7SL791P RNA5SP196 |
| GH05G146344 | 0.8 | FANTOM5 ENCODE | 2.5 | +171.3 | 171265 | 0.3 | RNF2 SUZ12 CBX2 EZH2 | ENSG00000250025 GRXCR2 GPR151 GC05P146343 GC05P146357 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around GPR151 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for GPR151 Gene
- Chromosome:
- 5
- Start:
- 146,513,103 bp from pter
- End:
- 146,516,190 bp from pter
- Size:
- 3,088 bases
- Orientation:
- Minus strand
Genomic View for GPR151 Gene
Genes around GPR151 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q32 by Ensembl
- 5q32 by Entrez Gene
- 5q32 by HGNC
GPR151 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GPR151 Gene
Proteins for GPR151 Gene
-
Protein details for GPR151 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8TDV0-GP151_HUMAN
- Recommended name:
- Probable G-protein coupled receptor 151
- Protein Accession:
- Q8TDV0
- Q86SN8
- Q8NGV2
Protein attributes for GPR151 Gene
- Size:
- 419 amino acids
- Molecular mass:
- 46637 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAC05899.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Post-translational modifications for GPR151 Gene
Other Protein References for GPR151 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for GPR151
-
Cloud-Clone Corp. Antibodies for GPR151
- Invitrogen Antibodies for GPR151
- antibodies-online Antibodies for GPR151: See all 86
- Search GeneTex for Antibodies for GPR151
Protein Products
-
OriGene Purified Proteins for GPR151
- Search Origene for MassSpec and Protein Over-expression Lysates for GPR151
- Origene Custom Protein Services for GPR151
-
Cloud-Clone Corp. Proteins for GPR151
- Search GeneTex for Proteins for GPR151
Assay Products
- antibodies-online Kits for GPR151: See all 1
No data available for DME Specific Peptides for GPR151 Gene
Domains & Families for GPR151 Gene
Gene Families for GPR151 Gene
- HGNC:
- IUPHAR :
Protein Domains for GPR151 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for GPR151 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8TDV0- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for GPR151 Gene
Molecular function for GPR151 Gene
- UniProtKB/Swiss-Prot Function:
- Orphan receptor.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004930 | G-protein coupled receptor activity | IEA | -- |
Phenotypes for GPR151 Gene
- MGI mutant phenotypes for GPR151:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for GPR151:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability in esophageal squamous lineage
- Decreased viability ratio
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased shRNA abundance (Z-score > 2)
- Increased G1 DNA content
- Decreased shRNA abundance (Z-score < -2)
Animal Models for GPR151 Gene
- MGI Knock Outs for GPR151:
-
- Gpr151 tm1Dgen
Animal Model Products
-
Taconic Biosciences Mouse Models for GPR151
- Cyagen custom Knockout/knockin (KOKI) mouse models for GPR151
-
-
ViGene Biosciences lentiviral particle packaged cDNA for GPR151 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GPR151 gene
- Search ViGene Biosciences for GPR151
CRISPR Products
-
OriGene CRISPR knockouts for GPR151
-
Santa Cruz Biotechnology (SCBT) CRISPR for GPR151
- GenScript: Design CRISPR guide RNA sequences for GPR151
miRNA for GPR151 Gene
- miRTarBase miRNAs that target GPR151
miRNA Products
- Search ViGene Biosciences for GPR151
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for GPR151
- Browse OriGene Inhibitory RNA Products For GPR151
-
ViGene Biosciences ready-to-package AAV shRNAs for GPR151 gene
Clone Products
-
OriGene ORF clones in human for GPR151
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Addgene plasmids for GPR151
- VectorBuilder custom plasmid, inducible vectors for GPR151
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GPR151
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for GPR151
-
ViGene Biosciences adenoviral particle packaged cDNA for GPR151 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for GPR151 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GPR151 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR151 Gene
Localization for GPR151 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GPR151 Gene
- Cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for GPR151 Gene
No Data Available
Interacting Proteins for GPR151 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for GPR151 Gene
Transcripts for GPR151 Gene
mRNA/cDNA for GPR151 Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (4) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GPR151 Gene
CRISPR Products
-
OriGene CRISPR knockouts for GPR151
-
Santa Cruz Biotechnology (SCBT) CRISPR for GPR151
- GenScript: Design CRISPR guide RNA sequences for GPR151
miRNA Products
- Search ViGene Biosciences for GPR151
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for GPR151
- Browse OriGene Inhibitory RNA Products For GPR151
-
ViGene Biosciences ready-to-package AAV shRNAs for GPR151 gene
Clone Products
-
OriGene ORF clones in human for GPR151
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for GPR151
- VectorBuilder custom plasmid, inducible vectors for GPR151
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GPR151
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for GPR151 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
mRNA differential expression in normal tissues according to GTEx for GPR151 Gene
This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.7), Brain - Anterior cingulate cortex (BA24) (x6.4), Brain - Frontal Cortex (BA9) (x6.2), Brain - Cortex (x4.6), and Brain - Substantia nigra (x4.5).
NURSA nuclear receptor signaling pathways regulating expression of GPR151 Gene:
GPR151SOURCE GeneReport for Unigene cluster for GPR151 Gene:
Hs.483732Primer Products
-
OriGene qPCR primer pairs for GPR151
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR151 Gene
Orthologs for GPR151 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GPR151 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | GPR151 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | GPR151 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Gpr151 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Gpr151 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | GPR151 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | GPR151 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | GPR151 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | gpr151 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC100538082 34 |
|
||
| GPR151 35 |
|
OneToOne |
- Species where no ortholog for GPR151 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for GPR151 Gene
No data available for Paralogs for GPR151 Gene
Variants for GPR151 Gene
| SNP ID | Clin | Chr 05 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000003124 | -- | 146,517,171(+) | ATTGC(C/T)TAAGG | upstream-variant-2KB | |
| rs1002021721 | -- | 146,514,556(+) | GGGTA(C/T)CCAGT | downstream-variant-500B | |
| rs1003610712 | -- | 146,517,577(+) | GTGGC(A/T)AGTCA | upstream-variant-2KB | |
| rs1004452677 | -- | 146,517,997(+) | AGTGA(C/T)GTTTT | upstream-variant-2KB | |
| rs1004827206 | -- | 146,517,797(+) | TTTTG(C/T)TTTCC | upstream-variant-2KB |
Residual Variation Intolerance Score:
96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.28;
70.36% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for GPR151 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GPR151
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GPR151 Gene
Disorders for GPR151 Gene
Relevant External Links for GPR151
No disorders were found for GPR151 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR151 Gene
Publications for GPR151 Gene
- The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis D.K. … Gaitanaris G.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4 64
- Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S. … Mitaku S. (FEBS Lett. 2002) 3 4 64
- Activation of calcitonin receptor and calcitonin receptor-like receptor by membrane-anchored ligands. (PMID: 19903822) Chang C.L. … Hsu S.Y. (J. Biol. Chem. 2010) 22 64
- Functional characterization of two human receptor activity-modifying protein 3 variants. (PMID: 20034525) Bailey R.J. … Hay D.L. (Peptides 2010) 22 64
- Structure-function relationships of the N-terminus of receptor activity-modifying proteins. (PMID: 20015292) Qi T. … Hay D.L. (Br. J. Pharmacol. 2010) 22 64
Products for GPR151 Gene
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- OriGene Purified Proteins for GPR151
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- GenScript: Design CRISPR guide RNA sequences for GPR151
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- Novus Biologicals Antibodies for GPR151
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- Humanized Mice
- Invitrogen Antibodies for GPR151
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- Addgene plasmids for GPR151
- antibodies-online Antibodies for GPR151: See all 86
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- ViGene Biosciences adenoviral particle packaged cDNA for GPR151 gene
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- Horizon Cell Lines for GPR151
- Cyagen custom Knockout/knockin (KOKI) mouse models for GPR151
- VectorBuilder custom plasmid, inducible vectors for GPR151
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GPR151
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for GPR151 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
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- (135) Gene Damage Index
- (136) ViGene Biosciences
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- (138) UDN
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- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer