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GPR151 Gene

protein-coding GIFtS: 45
GCID: GC05M145874

G Protein-Coupled Receptor 151

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
G Protein-Coupled Receptor 151¹ ²		GALR4²
Galanin Receptor 4¹ ²		GALRL²
GPCR-2037² ³		GPCR²
PGR7² ³		Probable G-Protein Coupled Receptor 151²
G-Protein Coupled Receptor PGR7² ³		Putative G-Protein Coupled Receptor²

External Ids:	HGNC: 23624¹	Entrez Gene: 134391²	Ensembl: ENSG00000173250⁷	UniProtKB: Q8TDV0³

Export aliases for GPR151 gene to outside databases

Previous GC identifers: GC05M145922 GC05M141041

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for GPR151 Gene:

GPR151 (G protein-coupled receptor 151) is a protein-coding gene. Diseases associated with GPR151 include polycystic kidney disease, and kidney disease. GO annotations related to this gene include G-protein coupled receptor activity.

UniProtKB/Swiss-Prot: GP151_HUMAN, Q8TDV0

Function: Orphan receptor

Gene Wiki entry for GPR151 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000005.10 NC_018916.2 NT_029289.12

Regulatory elements:

Regulatory transcription factor binding sites in the GPR151 gene promoter:
TBP NF-1 FOXD1 Nkx2-5 POU3F2 E47 HOXA5 Hand1 ATF6 Ik-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GPR151 promoter sequence

Search Chromatin IP Primers for GPR151

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GPR151

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q32 Ensembl cytogenetic band: 5q32 HGNC cytogenetic band: 5q32

GPR151 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPR151 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M145874: view genomic region (about GC identifiers)

Start:	145,892,666 bp from pter	End:	145,895,753 bp from pter
Size:	3,088 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: GP151_HUMAN, Q8TDV0 (See protein sequence)

Recommended Name: Probable G-protein coupled receptor 151

Size: 419 amino acids; 46637 Da

Sequence caution: Sequence=BAC05899.1; Type=Erroneous initiation;

Secondary accessions: Q86SN8 Q8NGV2

Explore the universe of human proteins at neXtProt for GPR151: NX_Q8TDV0

Explore proteomics data for GPR151 at MOPED

Post-translational modifications:

Glycosylation² at Asn10, Asn15

See GPR151 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_919227.2

ENSEMBL proteins:

ENSP00000308733

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

GPCRAO: GPCR / Class A : Orphans

IUPHAR Guide to PHARMACOLOGY protein family classification: GPR151

Class A Orphans

2 InterPro protein domains:

IPR017452 GPCR_Rhodpsn_7TM

IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q8TDV0

ProtoNet protein and cluster: Q8TDV0

UniProtKB/Swiss-Prot: GP151_HUMAN, Q8TDV0

Similarity: Belongs to the G-protein coupled receptor 1 family

GPR151 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: GP151_HUMAN, Q8TDV0

Function: Orphan receptor

Gene Ontology (GO): 1 molecular function term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004930	G-protein coupled receptor activity	IEA	--

GPR151 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for GPR151:

Increased G2M DNA content

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Gpr151):

normal

GPR151 for phenotypes About GeneDecksing

Animal Models:

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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

GP151_HUMAN, Q8TDV0: Cell membrane; Multi-pass membrane protein

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
plasma membrane	5
chloroplast	2

About this image

Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral component of membrane	IEA	--

GPR151 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Pathway & Disease-focused RT² Profiler PCR Array including GPR151:

G Protein Coupled Receptors 384HT in human mouse rat

Interactions:

GeneGlobe Interaction Network for GPR151

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for GPR151 (Q8TDV0³ ENSP00000308733⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GAL	P22466³, ENSP00000265643⁴	I2D: score=1 STRING: ENSP00000265643

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Gene Ontology (GO): 1 biological process term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007186	G-protein coupled receptor signaling pathway	--	--

GPR151 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for GPR151 (GP151)

1 Novoseek inferred chemical compound relationship for GPR151 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
dopamine	0	1	11690637 (1)

GPR151 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for GPR151 gene:

NM_194251.2

Unigene Cluster for GPR151:

G protein-coupled receptor 151

Hs.483732 [show with all ESTs]

Unigene Representative Sequence: AY351676

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000311104(uc003lod.1)

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Additional mRNA sequence:

AY255557.1 AY351676.1

1 DOTS entry:

DT.100654705

4 AceView cDNA sequences:

AY351676 AY255557 NM_194251 AK122627

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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GPR151 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

GPR151 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database


Brain (Nervous System) fully expand to see all 17 entries
Thalamus
Septum

GPR151 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

GPR151 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.483732

Pathway & Disease-focused RT² Profiler PCR Array including GPR151:

G Protein Coupled Receptors 384HT in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for GPR151 gene from Selected species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Gpr151^{1 , 5}	G protein-coupled receptor 151^{1, 5}	82.69(n)¹ 78.26(a)¹		18 (22.71 cM)⁵ 240239¹ NM_181543.1¹ NP_853521.1¹ 42578020⁵
lizard (Anolis carolinensis)	Reptilia	GPR151⁶	G protein-coupled receptor 151	59(a)	1 ↔ 1	GL343234.1(427041-428279)
tropical clawed frog (Xenopus tropicalis)	Amphibia	gpr151¹	G protein-coupled receptor 151	60.54(n) 52.7(a)		100486417 XM_002935277.2 XP_002935323.1
zebrafish (Danio rerio)	Actinopterygii	LOC100538082¹	probable G-protein coupled receptor 151-like	54.44(n) 44.99(a)		100538082 XM_003199978.2 XP_003200026.1

ENSEMBL Gene Tree for GPR151 (if available)
TreeFam Gene Tree for GPR151 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183583591^1,2		--	145893942(+)	`TTAATA/GTGTTA`	1	--	ds500¹		0	--	--	--	--
rs188629147^1,2		--	145894050(+)	`AAAGGA/GGCTCA`	1	--	ds500¹		0	--	--	--	--
rs148331022^1,2		--	145894292(+)	`TGTAGA/TTTGTG`	1	--	ds500¹		0	--	--	--	--
rs141483961^1,2		--	145894325(+)	`GGTAAC/TAATTA`	1	--	ds500¹		0	--	--	--	--
rs192806662^1,2		--	145894335(+)	`ATATCA/GGTTTG`	1	--	ds500¹		0	--	--	--	--
rs150820698^1,2	C	--	145894432(+)	`CCTTCC/TCCTGT`	2	G	syn¹		0	--	--	--	--
rs139779292^1,2	F	--	145894462(+)	`CAGGGG/TATAGG`	2	I	syn¹		1		NA	4548
rs142971995^1,2	C,F	--	145894493(+)	`GGACTG/CTGTCC`	2	/T /R	mis¹		1		NA	4550
rs201437088^1,2	C	--	145894518(+)	`CTGCTC/GTACGT`	2	Q E	mis¹		0	--	--	--	--
rs139276521^1,2	C,F	--	145894522(+)	`TCTACG/ATCAGG`	2	/D	syn¹		2		NA EU	5873

HapMap Linkage Disequilibrium report for GPR151 (145892666 - 145895753 bp)

Structural Variations
Database of Genomic Variants (DGV) variations for GPR151: --

Site Specific Mutation Identification with PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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5 diseases for GPR151:
About MalaCards

polycystic kidney disease kidney disease hiv-1 cerebritis

breast cancer

GPR151 for disorders About GeneDecksing

Genetic Association Database (GAD): GPR151

Export disorders for GPR151 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for GPR151 gene, integrated from 10 sources (see all 41):
(articles sorted by number of sources associating them with GPR151)

Utopia: connect your pdf to the dynamic
world of online information

The G protein-coupled receptor repertoires of human and mouse. (PubMed id 12679517)^{1, 2, 3} Vassilatis D.K.... Gaitanaris G.A. (Proc. Natl. Acad. Sci. U.S.A. 2003)
Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878)^{1, 2} Takeda S.... Mitaku S. (FEBS Lett. 2002)
Cloning and characterization of a novel G-protein-coupled receptor with homology to galanin receptors. (PubMed id 15111018)¹ Ignatov A....Schaller H.C. (Neuropharmacology 2004)
(PubMed id )²
Activation of calcitonin receptor and calcitonin receptor-like receptor by membrane-anchored ligands. (PubMed id 19903822)⁹ Chang C.L....Hsu S.Y. (J. Biol. Chem. 2010)
Isolation and chromosomal localization of GPR31, a human gene encoding a putative G protein-coupled receptor. (PubMed id 9205127)⁹ Zingoni A....Napolitano M. (Genomics 1997)
Structure-function relationships of the N-terminus of receptor activity-modifying proteins. (PubMed id 20015292)⁹ Qi T. and Hay D.L. (Br. J. Pharmacol. 2010)
In silico investigation of intronless Rhodopsin-like G-protein coupled receptors (GPCR) in the human genome: features and classification. (PubMed id 19388584)⁹ Alem K....RebaA^ A. (Arch Inst Pasteur Tunis 2007)
Signaling through a G Protein-coupled receptor and its corresponding G protein follows a stoichiometrically limited model. (PubMed id 17420253)⁹ Philip F....Scarlata S. (J. Biol. Chem. 2007)
Purinergic-receptor oligomerization: implications for neural functions in the central nervous system. (PubMed id 15545012)⁹ Nakata H....Kamiya T. (Neurotox Res 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 134391	HGNC: 23624	AceView: GPR151	Ensembl:ENSG00000173250	euGenes: HUgn134391
ECgene: GPR151	H-InvDB: GPR151

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for GPR151	Pharmacogenomics, SNPs, Pathways

Intellectual Property for GPR151 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for GPR151 gene:
Search GeneIP for patents involving GPR151

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GPR151 Gene

G Protein-Coupled Receptor 151

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GPR151 Gene

G Protein-Coupled Receptor 151

Aliasesfor GPR151 gene

Summariesfor GPR151 gene

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GPR151 Human Recombinant Protein Products:

GPR151 Antibody Products:

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