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Aliases for GPR150 Gene

Aliases for GPR150 Gene

  • G Protein-Coupled Receptor 150 2 3 5
  • Probable G-Protein Coupled Receptor 150 3
  • Seven Transmembrane Helix Receptor 3
  • PGR11 3

External Ids for GPR150 Gene

Previous GeneCards Identifiers for GPR150 Gene

  • GC00U914422
  • GC05P095032
  • GC05P094981
  • GC05P090146

Summaries for GPR150 Gene

Entrez Gene Summary for GPR150 Gene

  • This gene encodes an orphan member of the class A rhodopsin-like family of G-protein-coupled receptors (GPCRs). Within the rhodopsin-like family, this gene is a member of the vasopressin-like subfamily that also includes vasopressin and oxytocin receptors. The silencing of this gene, due to promoter methylation, is associated with ovarian cancer progression. All GPCRs have a transmembrane domain that includes seven transmembrane alpha-helices. A general feature of GPCR signaling is the agonist-induced conformational change in the receptor, leading to activation of the heterotrimeric G protein. The activated G protein then binds to and activates numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. [provided by RefSeq, Jul 2017]

GeneCards Summary for GPR150 Gene

GPR150 (G Protein-Coupled Receptor 150) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and G alpha (s) signalling events. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity.

UniProtKB/Swiss-Prot for GPR150 Gene

  • Orphan receptor.

Gene Wiki entry for GPR150 Gene

Additional gene information for GPR150 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR150 Gene

Genomics for GPR150 Gene

GeneHancer (GH) Regulatory Elements for GPR150 Gene

Promoters and enhancers for GPR150 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I095619 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 558.3 +3.0 3023 2.9 RING1 ELF3 CTCF TFAP4 MXI1 FOXA2 BACH1 MAX SIN3A EBF1 GPR150 GC05M095611 GC05M095620 SPATA9 RFESD
GH05I095616 Enhancer 0.7 ENCODE 559.6 -1.1 -1107 2 SMAD1 EBF1 BMI1 BATF IRF4 NFATC1 ATF7 ETV6 IKZF2 RUNX3 GPR150 GC05M095611 ARSK
GH05I095645 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 7.7 +29.5 29515 4.9 HDGF FOXA2 PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A DMAP1 RFESD SPATA9 RHOBTB3 ENSG00000250240 GPR150 LINC01554 LOC105379090
GH05I095640 Enhancer 1.1 FANTOM5 Ensembl ENCODE 11.6 +23.3 23318 2.3 FOXA2 TAF1 MAX ZNF644 RAD21 YY1 TEAD3 GATA3 RXRA REST SPATA9 GPR150 LINC01554 RHOBTB3 ENSG00000250240 ENSG00000251409 GLRX LOC105379091 RFESD GC05M095620
GH05I095590 Enhancer 0.8 Ensembl ENCODE 12.4 -26.5 -26544 3.1 JUN NR2F1 JUNB EBF1 BATF ATF2 IRF4 GABPA JUND IKZF1 TTC37 GPR150 RNU6-308P ARSK
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GPR150 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR150 gene promoter:

Genomic Locations for GPR150 Gene

Genomic Locations for GPR150 Gene
chr5:95,618,296-95,622,142
(GRCh38/hg38)
Size:
3,847 bases
Orientation:
Plus strand
chr5:94,955,782-94,957,846
(GRCh37/hg19)

Genomic View for GPR150 Gene

Genes around GPR150 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR150 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR150 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR150 Gene

Proteins for GPR150 Gene

  • Protein details for GPR150 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGU9-GP150_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 150
    Protein Accession:
    Q8NGU9

    Protein attributes for GPR150 Gene

    Size:
    434 amino acids
    Molecular mass:
    46353 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR150 Gene

Post-translational modifications for GPR150 Gene

No Post-translational modifications

Other Protein References for GPR150 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR150 Gene

Domains & Families for GPR150 Gene

Gene Families for GPR150 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR150 Gene

Suggested Antigen Peptide Sequences for GPR150 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NGU9

UniProtKB/Swiss-Prot:

GP150_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR150: view

Function for GPR150 Gene

Molecular function for GPR150 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Phenotypes From GWAS Catalog for GPR150 Gene

Gene Ontology (GO) - Molecular Function for GPR150 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GPR150: view
genes like me logo Genes that share phenotypes with GPR150: view

Animal Model Products

CRISPR Products

miRNA for GPR150 Gene

miRTarBase miRNAs that target GPR150

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR150 Gene

Localization for GPR150 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR150 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR150 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR150 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR150: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR150 Gene

Pathways & Interactions for GPR150 Gene

genes like me logo Genes that share pathways with GPR150: view

Pathways by source for GPR150 Gene

Gene Ontology (GO) - Biological Process for GPR150 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with GPR150: view

No data available for SIGNOR curated interactions for GPR150 Gene

Drugs & Compounds for GPR150 Gene

No Compound Related Data Available

Transcripts for GPR150 Gene

mRNA/cDNA for GPR150 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR150 Gene

G protein-coupled receptor 150:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR150 Gene

No ASD Table

Relevant External Links for GPR150 Gene

GeneLoc Exon Structure for
GPR150
ECgene alternative splicing isoforms for
GPR150

Expression for GPR150 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR150 Gene

mRNA differential expression in normal tissues according to GTEx for GPR150 Gene

This gene is overexpressed in Pancreas (x10.1), Brain - Cortex (x4.3), Brain - Frontal Cortex (BA9) (x4.2), and Brain - Anterior cingulate cortex (BA24) (x4.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR150 Gene



NURSA nuclear receptor signaling pathways regulating expression of GPR150 Gene:

GPR150

SOURCE GeneReport for Unigene cluster for GPR150 Gene:

Hs.143315
genes like me logo Genes that share expression patterns with GPR150: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR150 Gene

Orthologs for GPR150 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPR150 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR150 33 34
  • 96.43 (n)
rat
(Rattus norvegicus)
Mammalia Gpr150 33
  • 79.22 (n)
mouse
(Mus musculus)
Mammalia Gpr150 33 16 34
  • 78.74 (n)
dog
(Canis familiaris)
Mammalia GPR150 33 34
  • 77.57 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 25 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 21 (a)
ManyToMany
chicken
(Gallus gallus)
Aves GNRHR 34
  • 18 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia GPR150 34
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485220 33
  • 51.68 (n)
zebrafish
(Danio rerio)
Actinopterygii gnrhr4 34
  • 17 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta GRHRII 34
  • 14 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ntr-2 34
  • 14 (a)
ManyToMany
Species where no ortholog for GPR150 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPR150 Gene

ENSEMBL:
Gene Tree for GPR150 (if available)
TreeFam:
Gene Tree for GPR150 (if available)

Paralogs for GPR150 Gene

(1) SIMAP similar genes for GPR150 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GPR150: view

No data available for Paralogs for GPR150 Gene

Variants for GPR150 Gene

Sequence variations from dbSNP and Humsavar for GPR150 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000311297 -- 95,619,114(+) A/G upstream_transcript_variant
rs1000646336 -- 95,620,152(+) C/A upstream_transcript_variant
rs1000709356 -- 95,618,828(+) A/G upstream_transcript_variant
rs1001536102 -- 95,619,534(+) A/G upstream_transcript_variant
rs1001881986 -- 95,619,230(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GPR150 Gene

Variant ID Type Subtype PubMed ID
esv27306 CNV loss 19812545
nsv598955 CNV gain 21841781
nsv598956 CNV gain 21841781
nsv598957 CNV gain+loss 21841781
nsv598958 CNV loss 21841781
nsv598959 CNV gain 21841781
nsv823145 CNV gain 20364138

Variation tolerance for GPR150 Gene

Gene Damage Index Score: 3.48; 55.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR150 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR150

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR150 Gene

Disorders for GPR150 Gene

Additional Disease Information for GPR150

No disorders were found for GPR150 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR150 Gene

Publications for GPR150 Gene

  1. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis DK … Gaitanaris GA (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 58
  2. Constitutive Activity among Orphan Class-A G Protein Coupled Receptors. (PMID: 26384023) Martin AL … Aronstam RS (PloS one 2015) 3 58
  3. Sequence-structure based phylogeny of GPCR Class A Rhodopsin receptors. (PMID: 24503482) Kakarala KK … Jamil K (Molecular phylogenetics and evolution 2014) 3 58
  4. Identification of PRTFDC1 silencing and aberrant promoter methylation of GPR150, ITGA8 and HOXD11 in ovarian cancers. (PMID: 17303177) Cai LY … Ushijima T (Life sciences 2007) 3 58
  5. Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship. (PMID: 15777626) Gloriam DE … Fredriksson R (Biochimica et biophysica acta 2005) 3 58

Products for GPR150 Gene

Sources for GPR150 Gene

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