GPR15 Gene
protein-coding GIFtS: 52
GCID: GC03P098250
|
|
G protein-coupled receptor 15
| |
Aliases
for GPR15 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| G Protein-Coupled Receptor 151 2 | | Brother Of Bonzo2 3 | | BOB2 | | G-Protein Coupled Receptor 152 | | BoB3 |
Export aliases for GPR15 gene to outside databasesPrevious GC identifers: GC03P094873 GC03P097554 GC03P099532 GC03P099571 GC03P099733 GC03P095623 |
Summaries
for GPR15 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GPR15:
This gene encodes a G protein-coupled receptor that acts as a chemokine receptor for human immunodeficiency virus type1 and 2. The encoded protein localizes to the cell membrane. (provided by RefSeq, Nov 2012)
UniProtKB/Swiss-Prot: GPR15_HUMAN, P49685Function: Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection
Gene Wiki entry for GPR15
|
Genomic Views
for GPR15 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GPR15 gene promoter:
AhR AML1a GATA-3 Bach2 FOXD1 IRF-1 Gfi-1 MRF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for GPR15
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPR15 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q11.2-q13.1 Ensembl cytogenetic band: 3q11.2 HGNC cytogenetic band: 3q11.2-q13.1GPR15 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P098250: view genomic region
(about GC identifiers)
Start:
|
98,250,743 bp from pter |
End:
|
98,251,960 bp from pter |
Size:
|
1,218 bases |
Orientation:
|
plus strand |
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Proteins
for GPR15 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GPR15_HUMAN, P49685 (See
protein sequence)Recommended Name: G-protein coupled receptor 15 Size: 360 amino acids; 40787 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q3MIL4 Q6ISN6Explore the universe of human proteins at neXtProt for GPR15: NX_P49685
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P49685
GPR15 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005281.1
ENSEMBL proteins: ENSP00000284311
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005887 | integral to plasma membrane |
TAS | 8838812 |
GPR15 for ontologies About GeneDecksing
GPR15 Antibody Products:
Assay Products for GPR15: |
Protein
Domains /
Families
for GPR15 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GPR15 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P49685ProtoNet protein and cluster: P49685 UniProtKB/Swiss-Prot: GPR15_HUMAN, P49685Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for GPR15 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: GPR15_HUMAN, P49685Function: Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection Genatlas biochemistry entry for GPR15:G protein coupled receptor 15
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPR15 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPR15
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR15 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
TAS | 8838812 | | GO:0045028 | G-protein coupled purinergic nucleotide receptor activity |
IEA | -- |
GPR15 for ontologies About GeneDecksing
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Gpr15):
GPR15 for phenotypes About GeneDecksing
|
Pathways & Interactions
for GPR15 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | |
1  BioSystems Pathway for GPR15
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GPR15
1 Interacting protein for GPR15 (P496853) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007186 | G-protein coupled receptor signaling pathway |
TAS | 8838812 |
GPR15 for ontologies About GeneDecksing
|
Drugs & Compounds
for GPR15 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for GPR15
Search CenterWatch for drugs/clinical trials and news about GPR15
|
Transcripts
for GPR15 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GPR15 gene: NM_005290.2 Unigene Cluster for GPR15: G protein-coupled receptor 15 Hs.563128 [show with all ESTs]Unigene Representative Sequence: NM_0052901 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000284311(uc011bgy.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPR15 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPR15
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: GPR15 (NM_005290) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GPR15 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPR15 |
Additional cDNA sequence: AK313375.1 BC069437.1 BC101779.1 BC101781.1 2 DOTS entries: DT.40222630 DT.100726641 2 AceView cDNA sequences: NM_005290 BC069437
GeneLoc Exon Structure
|
Expression
for GPR15 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GPR15 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGAAGATTT
About this image
See GPR15 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GPR15
SOURCE GeneReport for Unigene cluster: Hs.563128
SABiosciences Expression via Pathway-Focused PCR Array including GPR15: | G Protein Coupled Receptors 384HT in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GPR15
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GPR15 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPR15 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPR15 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR15 |
Orthologs
for GPR15 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for GPR15 gene from 2/7 species (see all 7) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
GPR151 |
G protein-coupled receptor 15 |
64.76(n)
61.45(a) |
|
427956 XM_425528.2 XP_425528.2 |
lizard
(Anolis carolinensis) |
Reptilia |
GPR156 |
-- |
55(a) |
1 ↔ 1 |
3(176314907-176315917) |
ENSEMBL Gene Tree for GPR15 (if available)
TreeFam Gene Tree for GPR15 (if available) |
Paralogs
for GPR15 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GPR15 gene
- RXFP32 BDKRB12 AGTR22 AGTR12 GPR252 CXCR72 APLNR2 BDKRB22
- RXFP42 GPR1822
17 SIMAP similar genes for GPR15 using alignment to 2 protein entries: GPR15_HUMAN (see all proteins):AGTR1 CXCR2 GPR25 IL8RB AGTR2 APLNR
SSTR5 BLR1 CXCR4 CXCR5 CXCR6 CCR6
CXCR1 CCR9 GPR1 CCR4 CMKLR1
GPR15 for paralogs About GeneDecksing
|
Genomic Variants
for GPR15 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GPR15 (98250743 - 98251960 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for GPR15
1 CNV: 6197 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GPR15 |
|
Disorders
/ Diseases
for GPR15 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GPR15 for disorders About GeneDecksing
OMIM gene information: 601166
OMIM disorders: --
5  diseases for GPR15: About MalaCardsosteosarcoma breast lymphoma dementia immunodeficiency
hiv type 1
1 disease from the University of Copenhagen DISEASES database for GPR15:Lymphoma 2 Novoseek disease relationships for GPR15 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| immunodeficiency |
58.9 |
4 |
11878872 (2), 9791028 (1) |
| osteosarcoma |
31.9 |
2 |
9971817 (1), 11878872 (1) |
Export disorders for GPR15 gene to outside databases
|
Publications
for GPR15 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GPR15 gene, integrated from 9 sources (see all 33):
(articles sorted by number of sources associating them with GPR15) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel human gene encoding a G-protein-coupled receptor (GPR15) is located on chromosome 3. (PubMed id 8838812)1, 2, 3 Heiber M....O'Dowd B.F. (1996)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Use of alternate coreceptors on primary cells by two HIV-1 isolates. (PubMed id 15992849)1, 9 Cilliers T....Morris L. (2005)
- Evidence of extended alternate coreceptor usage by HIV -1 clade C envelope obtained from an Indian patient. (PubMed id 22086059)1 Gharu L....Bhattacharya J. (2012)
- Phosphorylation-dependent C-terminal binding of 14-3- 3 proteins promotes cell surface expression of HIV co-receptor GPR15. (PubMed id 21189250)1 Okamoto Y. and Shikano S. (2011)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- CCR5, GPR15, and CXCR6 are major coreceptors of human immunodeficiency virus type 2 variants isolated from individuals with and without plasma viremia. (PubMed id 15650194)1 Blaak H....Osterhaus A.D. (2005)
- The virotoxin model of HIV-1 enteropathy: involvement of GPR15/Bob and galactosylceramide in the cytopathic effects induced by HIV-1 gp120 in the HT-29-D4 intestinal cell line. (PubMed id 12566994)1 Maresca M....Clayton F. (2003)
- Expression of chemokines and their receptors in human and simian astrocytes: evidence for a central role of TNF alpha and IFN gamma in CXCR4 and CCR5 modulation. (PubMed id 12555203)1 Croitoru-Lamoury J....Dormont D. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for GPR15 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GPR15 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GPR15 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GPR15 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GPR15 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for GPR15 gene:
Search GeneIP for patents involving GPR15
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GPR15 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for GPR15 | | OriGene shRNA RFP for GPR15 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GPR15 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GPR15 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for GPR15 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPR15 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPR15 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for GPR15 | | OriGene Custom Protein Services for GPR15 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GPR15 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GPR15 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPR15 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GPR15 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPR15 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPR15 |
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| |  |  |  |  | | | | |
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 | | | GPR15 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR15 |
|  |  |  | | | | ThermoFisher Antibodies for GPR15 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPR15 |
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