Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GPR15 Gene

Aliases for GPR15 Gene

  • G Protein-Coupled Receptor 15 2 3 5
  • Brother Of Bonzo 3 4
  • BOB 3 4
  • G-Protein Coupled Receptor 15 3

External Ids for GPR15 Gene

Previous GeneCards Identifiers for GPR15 Gene

  • GC03P094873
  • GC03P097554
  • GC03P099532
  • GC03P099571
  • GC03P099733
  • GC03P098250
  • GC03P095623

Summaries for GPR15 Gene

Entrez Gene Summary for GPR15 Gene

  • This gene encodes a G protein-coupled receptor that acts as a chemokine receptor for human immunodeficiency virus type 1 and 2. The encoded protein localizes to the cell membrane. [provided by RefSeq, Nov 2012]

GeneCards Summary for GPR15 Gene

GPR15 (G Protein-Coupled Receptor 15) is a Protein Coding gene. Diseases associated with GPR15 include Mediastinal Malignant Lymphoma and Mediastinal Gray Zone Lymphoma. Among its related pathways are G alpha (s) signalling events and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is GPR25.

UniProtKB/Swiss-Prot for GPR15 Gene

  • Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection.

Gene Wiki entry for GPR15 Gene

Additional gene information for GPR15 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR15 Gene

Genomics for GPR15 Gene

Regulatory Elements for GPR15 Gene

Enhancers for GPR15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H098535 1.4 FANTOM5 ENCODE dbSUPER 13.3 +6.8 6754 5.3 PKNOX1 ATF1 TBL1XR1 RB1 BMI1 BATF ZNF207 FOS ATF7 ETV6 GPR15 ST3GAL6-AS1 OR5K2 OR5K4 CPOX ST3GAL6 GC03M098547
GH03H098560 1.8 FANTOM5 Ensembl ENCODE dbSUPER 1.8 +33.1 33050 8.4 HDGF PKNOX1 TBL1XR1 RB1 BMI1 FEZF1 BATF ZNF143 ATF7 ETV6 CPOX OR5K2 ST3GAL6-AS1 ST3GAL6 GPR15 CLDND1 GC03M098547
GH03H098531 0.7 dbSUPER 0.7 +1.0 966 1.7 PKNOX1 SMAD5 CBFB ZBED1 SIN3A CHD1 RELA ZNF83 POLR2A IKZF1 RIOX2 DCBLD2 GPR15 GC03M098547
GH03H098525 1 ENCODE dbSUPER 0.4 -6.2 -6168 0.2 BACH1 BMI1 POLR2A EED ETV6 ZSCAN29 RUNX3 IKZF2 ZNF687 NR2F1 RPL38P4 GPR15
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPR15 on UCSC Golden Path with GeneCards custom track

Genomic Locations for GPR15 Gene

Genomic Locations for GPR15 Gene
1,252 bases
Plus strand

Genomic View for GPR15 Gene

Genes around GPR15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR15 Gene

Proteins for GPR15 Gene

  • Protein details for GPR15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G-protein coupled receptor 15
    Protein Accession:
    Secondary Accessions:
    • Q3MIL4
    • Q6ISN6

    Protein attributes for GPR15 Gene

    360 amino acids
    Molecular mass:
    40787 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR15 Gene

Post-translational modifications for GPR15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPR15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR15 Gene

Domains & Families for GPR15 Gene

Gene Families for GPR15 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR15 Gene

Suggested Antigen Peptide Sequences for GPR15 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR15: view

Function for GPR15 Gene

Molecular function for GPR15 Gene

GENATLAS Biochemistry:
G protein coupled receptor 15
UniProtKB/Swiss-Prot Function:
Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection.

Gene Ontology (GO) - Molecular Function for GPR15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA,TAS --
genes like me logo Genes that share ontologies with GPR15: view
genes like me logo Genes that share phenotypes with GPR15: view

Animal Models for GPR15 Gene

MGI Knock Outs for GPR15:

Animal Model Products

Clone Products

  • Addgene plasmids for GPR15

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GPR15 Gene

Localization for GPR15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR15 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR15 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8838812
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR15: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR15 Gene

Pathways & Interactions for GPR15 Gene

genes like me logo Genes that share pathways with GPR15: view

Pathways by source for GPR15 Gene

Gene Ontology (GO) - Biological Process for GPR15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS --
GO:0072678 T cell migration IEA --
genes like me logo Genes that share ontologies with GPR15: view

No data available for SIGNOR curated interactions for GPR15 Gene

Drugs & Compounds for GPR15 Gene

No Compound Related Data Available

Transcripts for GPR15 Gene

mRNA/cDNA for GPR15 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR15 Gene

G protein-coupled receptor 15:
Representative Sequences:

Clone Products

  • Addgene plasmids for GPR15

Alternative Splicing Database (ASD) splice patterns (SP) for GPR15 Gene

No ASD Table

Relevant External Links for GPR15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR15 Gene

Protein differential expression in normal tissues from HIPED for GPR15 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR15 Gene

Protein tissue co-expression partners for GPR15 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPR15 Gene:


SOURCE GeneReport for Unigene cluster for GPR15 Gene:


Evidence on tissue expression from TISSUES for GPR15 Gene

  • Liver(4.1)
genes like me logo Genes that share expression patterns with GPR15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR15 Gene

Orthologs for GPR15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR15 33 34
  • 99.44 (n)
(Bos Taurus)
Mammalia GPR15 33 34
  • 86.41 (n)
(Canis familiaris)
Mammalia GPR15 33 34
  • 82.78 (n)
(Rattus norvegicus)
Mammalia Gpr15 33
  • 80 (n)
(Mus musculus)
Mammalia Gpr15 33 16 34
  • 79.63 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 19 (a)
(Gallus gallus)
Aves GPR15 33 34
  • 64.33 (n)
(Anolis carolinensis)
Reptilia GPR15 34
  • 55 (a)
(Danio rerio)
Actinopterygii BX957297.1 34
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 26 (a)
Species where no ortholog for GPR15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR15 Gene

Gene Tree for GPR15 (if available)
Gene Tree for GPR15 (if available)

Paralogs for GPR15 Gene

Paralogs for GPR15 Gene

(15) SIMAP similar genes for GPR15 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GPR15: view

Variants for GPR15 Gene

Sequence variations from dbSNP and Humsavar for GPR15 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000219729 -- 98,533,436(+) TTTGG(C/G)CCTTT utr-variant-3-prime
rs1000335404 -- 98,533,156(+) TTTAG(A/G)AGTTA utr-variant-3-prime
rs1001282150 -- 98,532,857(+) CTATT(G/T)ACCCT reference, stop-gained
rs1001834914 -- 98,531,057(+) AATGA(C/T)GTTAA upstream-variant-2KB
rs1003566456 -- 98,530,132(+) AACCG(A/G)CAGGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GPR15 Gene

Variant ID Type Subtype PubMed ID
nsv834775 CNV gain 17160897
nsv834774 CNV loss 17160897
nsv591065 CNV gain 21841781
nsv236502 CNV deletion 16902084
dgv293n21 CNV loss 19592680

Variation tolerance for GPR15 Gene

Residual Variation Intolerance Score: 31.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.02; 80.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR15 Gene

Disorders for GPR15 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GPR15 Gene - From: DISEASES

Disorder Aliases PubMed IDs
mediastinal malignant lymphoma
  • lymphoma of mediastinum
mediastinal gray zone lymphoma
  • mediastinal b-cell lymphoma, unclassifiable, with features intermediate between diffuse large b-cell lymphoma and classical hodgkin lymphoma
- elite association - COSMIC cancer census association via MalaCards
Search GPR15 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GPR15

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GPR15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR15 Gene

Publications for GPR15 Gene

  1. A novel human gene encoding a G-protein-coupled receptor (GPR15) is located on chromosome 3. (PMID: 8838812) Heiber M … O'Dowd BF (Genomics 1996) 2 3 4 60
  2. Use of alternate coreceptors on primary cells by two HIV-1 isolates. (PMID: 15992849) Cilliers T … Morris L (Virology 2005) 3 22 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Smoking-induced expression of the GPR15 gene indicates its potential role in chronic inflammatory pathologies. (PMID: 26348578) Kõks G … Kõks S (The American journal of pathology 2015) 3 60
  5. The variable loop 3 in the envelope glycoprotein is critical for the atypical coreceptor usage of an HIV-1 strain. (PMID: 24897520) Xiang Y … Jiang C (PloS one 2014) 3 60

Products for GPR15 Gene

  • Addgene plasmids for GPR15

Sources for GPR15 Gene

Loading form....