Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GPR15 Gene

Aliases for GPR15 Gene

  • G Protein-Coupled Receptor 15 2 3 5
  • Brother Of Bonzo 3 4
  • BOB 3 4

External Ids for GPR15 Gene

Previous GeneCards Identifiers for GPR15 Gene

  • GC03P094873
  • GC03P097554
  • GC03P099532
  • GC03P099571
  • GC03P099733
  • GC03P098250
  • GC03P095623

Summaries for GPR15 Gene

Entrez Gene Summary for GPR15 Gene

  • This gene encodes a G protein-coupled receptor that acts as a chemokine receptor for human immunodeficiency virus type 1 and 2. The encoded protein localizes to the cell membrane. [provided by RefSeq, Nov 2012]

GeneCards Summary for GPR15 Gene

GPR15 (G Protein-Coupled Receptor 15) is a Protein Coding gene. Diseases associated with GPR15 include Mediastinal Gray Zone Lymphoma and Mediastinal Malignant Lymphoma. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ACKR3.

UniProtKB/Swiss-Prot for GPR15 Gene

  • Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection.

Gene Wiki entry for GPR15 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR15 Gene

Genomics for GPR15 Gene

Regulatory Elements for GPR15 Gene

Enhancers for GPR15 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPR15 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR15 Gene

98,531,899 bp from pter
98,533,150 bp from pter
1,252 bases
Plus strand

Genomic View for GPR15 Gene

Genes around GPR15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR15 Gene

Proteins for GPR15 Gene

  • Protein details for GPR15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G-protein coupled receptor 15
    Protein Accession:
    Secondary Accessions:
    • Q3MIL4
    • Q6ISN6

    Protein attributes for GPR15 Gene

    360 amino acids
    Molecular mass:
    40787 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR15 Gene

Proteomics data for GPR15 Gene at MOPED

Post-translational modifications for GPR15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPR15 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GPR15 Gene

Domains & Families for GPR15 Gene

Gene Families for GPR15 Gene

Protein Domains for GPR15 Gene


Suggested Antigen Peptide Sequences for GPR15 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR15: view

Function for GPR15 Gene

Molecular function for GPR15 Gene

GENATLAS Biochemistry:
G protein coupled receptor 15
UniProtKB/Swiss-Prot Function:
Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection.
genes like me logo Genes that share phenotypes with GPR15: view

Animal Models for GPR15 Gene

MGI Knock Outs for GPR15:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR15

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GPR15 Gene

Localization for GPR15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR15 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GPR15 Gene COMPARTMENTS Subcellular localization image for GPR15 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with GPR15: view

Pathways & Interactions for GPR15 Gene

genes like me logo Genes that share pathways with GPR15: view

Pathways by source for GPR15 Gene

Interacting Proteins for GPR15 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000284311 P49685-GPR15_HUMAN for GPR15 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for GPR15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR15: view

No data available for SIGNOR curated interactions for GPR15 Gene

Drugs & Compounds for GPR15 Gene

No Compound Related Data Available

Transcripts for GPR15 Gene

mRNA/cDNA for GPR15 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR15 Gene

G protein-coupled receptor 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR15 Gene

No ASD Table

Relevant External Links for GPR15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR15 Gene

mRNA expression in normal human tissues for GPR15 Gene

Protein differential expression in normal tissues from HIPED for GPR15 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR15 Gene

SOURCE GeneReport for Unigene cluster for GPR15 Gene Hs.563128

genes like me logo Genes that share expression patterns with GPR15: view

Protein tissue co-expression partners for GPR15 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GPR15 Gene

Orthologs for GPR15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR15 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPR15 35
  • 86.41 (n)
  • 85.47 (a)
GPR15 36
  • 85 (a)
(Canis familiaris)
Mammalia GPR15 35
  • 82.78 (n)
  • 81.39 (a)
GPR15 36
  • 81 (a)
(Mus musculus)
Mammalia Gpr15 35
  • 79.63 (n)
  • 76.39 (a)
Gpr15 16
Gpr15 36
  • 76 (a)
(Pan troglodytes)
Mammalia GPR15 35
  • 99.44 (n)
  • 98.89 (a)
GPR15 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Gpr15 35
  • 80 (n)
  • 76.67 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 19 (a)
(Gallus gallus)
Aves GPR15 35
  • 64.33 (n)
  • 60.82 (a)
GPR15 36
  • 57 (a)
(Anolis carolinensis)
Reptilia GPR15 36
  • 55 (a)
(Danio rerio)
Actinopterygii BX957297.1 36
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
Species with no ortholog for GPR15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR15 Gene

Gene Tree for GPR15 (if available)
Gene Tree for GPR15 (if available)

Paralogs for GPR15 Gene

Paralogs for GPR15 Gene

(15) SIMAP similar genes for GPR15 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GPR15: view

Variants for GPR15 Gene

Sequence variations from dbSNP and Humsavar for GPR15 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs2230344 - 98,532,142(+) TCCTT(C/T)CAGTC reference, missense
rs35320046 - 98,532,367(-) GATCA(C/T)GTAGG reference, missense
rs1881672 -- 98,533,376(-) ATCCA(A/G)GAGTT downstream-variant-500B
rs1381087 -- 98,530,821(-) GCATG(G/T)ACACT upstream-variant-2KB
rs1406558 -- 98,530,995(-) GGATC(A/C)CCTCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GPR15 Gene

Variant ID Type Subtype PubMed ID
dgv293n21 CNV Loss 19592680
nsv834774 CNV Loss 17160897
nsv834775 CNV Gain 17160897
nsv236502 CNV Loss 16902084

Variation tolerance for GPR15 Gene

Residual Variation Intolerance Score: 31.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.02; 80.12% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GPR15 Gene

Disorders for GPR15 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GPR15 Gene - From: DISEASES

Disorder Aliases PubMed IDs
mediastinal gray zone lymphoma
  • mediastinal b-cell lymphoma, unclassifiable, with features intermediate between diffuse large b-cell lymphoma and classical hodgkin lymphoma
mediastinal malignant lymphoma
  • lymphoma of mediastinum
- elite association - COSMIC cancer census association via MalaCards
Search GPR15 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GPR15

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GPR15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR15 Gene

Publications for GPR15 Gene

  1. A novel human gene encoding a G-protein-coupled receptor (GPR15) is located on chromosome 3. (PMID: 8838812) Heiber M. … O'Dowd B.F. (Genomics 1996) 2 3 4 67
  2. Use of alternate coreceptors on primary cells by two HIV-1 isolates. (PMID: 15992849) Cilliers T. … Morris L. (Virology 2005) 3 23
  3. Toll-like receptor 3 signalling up-regulates expression of the HIV co-receptor G-protein coupled receptor 15 on human CD4+ T cells. (PMID: 24558379) Kiene M. … Chiodi F. (PLoS ONE 2014) 3
  4. Orphan receptor GPR15/BOB is up-regulated in rheumatoid arthritis. (PMID: 24725539) Cartwright A. … Middleton J. (Cytokine 2014) 3
  5. The variable loop 3 in the envelope glycoprotein is critical for the atypical coreceptor usage of an HIV-1 strain. (PMID: 24897520) Xiang Y. … Jiang C. (PLoS ONE 2014) 3

Products for GPR15 Gene

Sources for GPR15 Gene