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Aliases for GPR149 Gene

Aliases for GPR149 Gene

  • G Protein-Coupled Receptor 149 2 3
  • G-Protein Coupled Receptor PGR10 3 4
  • PGR10 3 4
  • G Protein-Coupled Receptor PGR10 3
  • IEDA 3

External Ids for GPR149 Gene

Previous GeneCards Identifiers for GPR149 Gene

  • GC03M155376
  • GC03M155538
  • GC03M154055
  • GC03M151450

Summaries for GPR149 Gene

GeneCards Summary for GPR149 Gene

GPR149 (G Protein-Coupled Receptor 149) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity and neuropeptide binding.

UniProtKB/Swiss-Prot for GPR149 Gene

  • Orphan receptor

Gene Wiki entry for GPR149 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR149 Gene

Genomics for GPR149 Gene

Regulatory Elements for GPR149 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GPR149 Gene

Chromosome:
3
Start:
154,337,672 bp from pter
End:
154,429,715 bp from pter
Size:
92,044 bases
Orientation:
Minus strand

Genomic View for GPR149 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPR149 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR149 Gene

Proteins for GPR149 Gene

  • Protein details for GPR149 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SP6-GP149_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 149
    Protein Accession:
    Q86SP6

    Protein attributes for GPR149 Gene

    Size:
    731 amino acids
    Molecular mass:
    80984 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR149 Gene

Proteomics data for GPR149 Gene at MOPED

Post-translational modifications for GPR149 Gene

  • Glycosylation at Asn 7, Asn 11, and Asn 21
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR149 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR149 Gene

Domains & Families for GPR149 Gene

Gene Families for GPR149 Gene

Protein Domains for GPR149 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR149 Gene

Graphical View of Domain Structure for InterPro Entry

Q86SP6

UniProtKB/Swiss-Prot:

GP149_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR149: view

Function for GPR149 Gene

Molecular function for GPR149 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor

Gene Ontology (GO) - Molecular Function for GPR149 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
GO:0042923 neuropeptide binding IBA --
genes like me logo Genes that share ontologies with GPR149: view
genes like me logo Genes that share phenotypes with GPR149: view

Animal Models for GPR149 Gene

MGI Knock Outs for GPR149:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPR149

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for GPR149 Gene

Localization for GPR149 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR149 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR149 Gene COMPARTMENTS Subcellular localization image for GPR149 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR149 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
GO:0043005 neuron projection IBA --
genes like me logo Genes that share ontologies with GPR149: view

Pathways & Interactions for GPR149 Gene

SuperPathways for GPR149 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for GPR149 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001546 preantral ovarian follicle growth IEA --
GO:0001547 antral ovarian follicle growth IEA --
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA --
GO:0007218 neuropeptide signaling pathway IBA --
genes like me logo Genes that share ontologies with GPR149: view

No data available for Pathways by source and SIGNOR curated interactions for GPR149 Gene

Drugs & Compounds for GPR149 Gene

No Compound Related Data Available

Transcripts for GPR149 Gene

mRNA/cDNA for GPR149 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR149 Gene

G protein-coupled receptor 149:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPR149

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR149 Gene

No ASD Table

Relevant External Links for GPR149 Gene

GeneLoc Exon Structure for
GPR149
ECgene alternative splicing isoforms for
GPR149

Expression for GPR149 Gene

mRNA expression in normal human tissues for GPR149 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR149 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x16.9), Brain - Caudate (basal ganglia) (x10.0), Brain - Putamen (basal ganglia) (x8.6), Pituitary (x4.9), and Brain - Hypothalamus (x4.4).

Protein differential expression in normal tissues from HIPED for GPR149 Gene

This gene is overexpressed in Pancreatic juice (44.0) and Peripheral blood mononuclear cells (25.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR149 Gene



SOURCE GeneReport for Unigene cluster for GPR149 Gene Hs.688231

genes like me logo Genes that share expression patterns with GPR149: view

Protein tissue co-expression partners for GPR149 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GPR149 Gene

Orthologs for GPR149 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR149 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPR149 35
  • 88.39 (n)
  • 85.6 (a)
GPR149 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPR149 35
  • 84.19 (n)
  • 81.74 (a)
GPR149 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr149 35
  • 82.26 (n)
  • 79.42 (a)
Gpr149 16
Gpr149 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPR149 35
  • 99.5 (n)
  • 99.59 (a)
GPR149 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr149 35
  • 81.53 (n)
  • 78.74 (a)
oppossum
(Monodelphis domestica)
Mammalia GPR149 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR149 36
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR149 35
  • 65.4 (n)
  • 62.22 (a)
GPR149 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR149 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr149 35
  • 64.87 (n)
  • 60.99 (a)
Species with no ortholog for GPR149:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GPR149 Gene

ENSEMBL:
Gene Tree for GPR149 (if available)
TreeFam:
Gene Tree for GPR149 (if available)

Paralogs for GPR149 Gene

No data available for Paralogs for GPR149 Gene

Variants for GPR149 Gene

Sequence variations from dbSNP and Humsavar for GPR149 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs696851 -- 154,385,522(-) ACATC(C/T)TACCC intron-variant
rs696852 -- 154,385,300(+) AAATT(C/T)AGAGC intron-variant
rs696853 -- 154,385,192(+) TTGCT(A/G)AAAAG intron-variant
rs696854 -- 154,384,912(+) AAATA(C/T)GAATC intron-variant
rs696855 -- 154,384,545(+) AATGT(A/C/T)TGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR149 Gene

Variant ID Type Subtype PubMed ID
nsv4073 CNV Insertion 18451855
esv2640775 CNV Deletion 19546169
esv1948933 CNV Deletion 18987734
esv2726081 CNV Deletion 23290073
esv1340831 CNV Deletion 17803354
esv5849 CNV Loss 19470904

Variation tolerance for GPR149 Gene

Residual Variation Intolerance Score: 11.88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.40; 42.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR149 Gene

HapMap Linkage Disequilibrium report
GPR149
Human Gene Mutation Database (HGMD)
GPR149

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR149 Gene

Disorders for GPR149 Gene

Relevant External Links for GPR149

Genetic Association Database (GAD)
GPR149
Human Genome Epidemiology (HuGE) Navigator
GPR149
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR149
genes like me logo Genes that share disorders with GPR149: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR149 Gene

Publications for GPR149 Gene

  1. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis D.K. … Gaitanaris G.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 67
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 67
  3. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PMID: 17903294) Yang Q. … O'Donnell C.J. (BMC Med. Genet. 2007) 67
  4. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 67

Products for GPR149 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate GPR149
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for GPR149
    • Block miRNA regulation of GPR149 using miScript Target Protectors

    Sources for GPR149 Gene

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