Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GPR149 Gene

Aliases for GPR149 Gene

  • G Protein-Coupled Receptor 149 2 3 5
  • PGR10 3 4
  • Probable G-Protein Coupled Receptor 149 3
  • G Protein-Coupled Receptor PGR10 3
  • G-Protein Coupled Receptor PGR10 4
  • IEDA 3
  • R35 3

External Ids for GPR149 Gene

Previous GeneCards Identifiers for GPR149 Gene

  • GC03M155376
  • GC03M155538
  • GC03M154055
  • GC03M151450

Summaries for GPR149 Gene

Entrez Gene Summary for GPR149 Gene

  • This gene encodes a seven-transmembrane G protein coupled receptor (GPCR) class A family member. Although categorized as a class A GPCR, the encoded protein lacks the first two charged amino acids of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix of class A receptors which is important for efficient G protein-coupled signal transduction. Mice with a knockout of the orthologous gene are viable and have normal maturation of the ovarian follicle, but show enhanced fertility and ovulation. All GPCRs have a common structural architecture consisting of seven transmembrane alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptor, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. [provided by RefSeq, Jul 2017]

GeneCards Summary for GPR149 Gene

GPR149 (G Protein-Coupled Receptor 149) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity and neuropeptide binding.

UniProtKB/Swiss-Prot for GPR149 Gene

  • Orphan receptor.

Gene Wiki entry for GPR149 Gene

Additional gene information for GPR149 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR149 Gene

Genomics for GPR149 Gene

Regulatory Elements for GPR149 Gene

Enhancers for GPR149 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H154464 0.2 ENCODE 12.1 -35.0 -35049 1 GPR149 ENSG00000243861
GH03H154366 0.2 ENCODE 10.7 +62.2 62165 1 DHX36 GPR149 DDX50P2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPR149 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR149 Gene

Chromosome:
3
Start:
154,337,672 bp from pter
End:
154,429,715 bp from pter
Size:
92,044 bases
Orientation:
Minus strand

Genomic View for GPR149 Gene

Genes around GPR149 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR149 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR149 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR149 Gene

Proteins for GPR149 Gene

  • Protein details for GPR149 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SP6-GP149_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 149
    Protein Accession:
    Q86SP6

    Protein attributes for GPR149 Gene

    Size:
    731 amino acids
    Molecular mass:
    80984 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR149 Gene

Post-translational modifications for GPR149 Gene

  • Glycosylation at posLast=77, isoforms=11, and posLast=2121
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR149 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR149 Gene

Domains & Families for GPR149 Gene

Gene Families for GPR149 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR149 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR149 Gene

Graphical View of Domain Structure for InterPro Entry

Q86SP6

UniProtKB/Swiss-Prot:

GP149_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR149: view

Function for GPR149 Gene

Molecular function for GPR149 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Phenotypes From GWAS Catalog for GPR149 Gene

Gene Ontology (GO) - Molecular Function for GPR149 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IBA --
GO:0042923 neuropeptide binding IBA --
genes like me logo Genes that share ontologies with GPR149: view
genes like me logo Genes that share phenotypes with GPR149: view

Animal Models for GPR149 Gene

MGI Knock Outs for GPR149:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR149

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GPR149
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GPR149 Gene

Localization for GPR149 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR149 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR149 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR149 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043005 neuron projection IBA --
genes like me logo Genes that share ontologies with GPR149: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR149 Gene

Pathways & Interactions for GPR149 Gene

SuperPathways for GPR149 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPR149 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001546 preantral ovarian follicle growth IEA --
GO:0001547 antral ovarian follicle growth IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA --
genes like me logo Genes that share ontologies with GPR149: view

No data available for Pathways by source and SIGNOR curated interactions for GPR149 Gene

Drugs & Compounds for GPR149 Gene

No Compound Related Data Available

Transcripts for GPR149 Gene

mRNA/cDNA for GPR149 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR149 Gene

G protein-coupled receptor 149:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GPR149
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for GPR149 Gene

No ASD Table

Relevant External Links for GPR149 Gene

GeneLoc Exon Structure for
GPR149
ECgene alternative splicing isoforms for
GPR149

Expression for GPR149 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR149 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR149 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x16.9), Brain - Caudate (basal ganglia) (x10.0), Brain - Putamen (basal ganglia) (x8.6), Pituitary (x4.9), and Brain - Hypothalamus (x4.4).

Protein differential expression in normal tissues from HIPED for GPR149 Gene

This gene is overexpressed in Pancreatic juice (44.0) and Peripheral blood mononuclear cells (25.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR149 Gene



Protein tissue co-expression partners for GPR149 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPR149 Gene:

GPR149

SOURCE GeneReport for Unigene cluster for GPR149 Gene:

Hs.688231
genes like me logo Genes that share expression patterns with GPR149: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR149 Gene

Orthologs for GPR149 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR149 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR149 33 34
  • 99.5 (n)
cow
(Bos Taurus)
Mammalia GPR149 33 34
  • 88.39 (n)
dog
(Canis familiaris)
Mammalia GPR149 33 34
  • 84.19 (n)
mouse
(Mus musculus)
Mammalia Gpr149 33 16 34
  • 82.26 (n)
rat
(Rattus norvegicus)
Mammalia Gpr149 33
  • 81.53 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR149 34
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR149 34
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR149 33 34
  • 65.4 (n)
lizard
(Anolis carolinensis)
Reptilia GPR149 34
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr149 33
  • 64.87 (n)
Species where no ortholog for GPR149 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GPR149 Gene

ENSEMBL:
Gene Tree for GPR149 (if available)
TreeFam:
Gene Tree for GPR149 (if available)

Paralogs for GPR149 Gene

No data available for Paralogs for GPR149 Gene

Variants for GPR149 Gene

Sequence variations from dbSNP and Humsavar for GPR149 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000064598 -- 154,392,634(+) TGGAC(A/C)AAAGT intron-variant
rs1000082250 -- 154,396,416(+) GGCTT(A/G)AAATG intron-variant
rs1000114511 -- 154,409,609(+) TAGAA(C/T)TGAAC intron-variant
rs1000134779 -- 154,396,632(+) TTCTA(C/T)AAAAC intron-variant
rs1000151949 -- 154,426,419(+) ATTTT(A/G)CAACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR149 Gene

Variant ID Type Subtype PubMed ID
dgv2621n106 CNV deletion 24896259
esv1340831 CNV deletion 17803354
esv1948933 CNV deletion 18987734
esv2640775 CNV deletion 19546169
esv2726081 CNV deletion 23290073
esv2763308 CNV loss 21179565
esv3562754 CNV deletion 23714750
esv5849 CNV loss 19470904
nsv1074634 CNV deletion 25765185
nsv1120814 CNV deletion 24896259
nsv1149433 CNV deletion 26484159
nsv4073 CNV insertion 18451855
nsv955535 CNV deletion 24416366
nsv967079 CNV duplication 23825009

Variation tolerance for GPR149 Gene

Residual Variation Intolerance Score: 11.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.40; 42.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR149 Gene

Human Gene Mutation Database (HGMD)
GPR149
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR149

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR149 Gene

Disorders for GPR149 Gene

Relevant External Links for GPR149

Genetic Association Database (GAD)
GPR149
Human Genome Epidemiology (HuGE) Navigator
GPR149
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR149

No disorders were found for GPR149 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR149 Gene

Publications for GPR149 Gene

  1. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis DK … Gaitanaris GA (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 4 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. A novel 7-transmembrane receptor expressed in nerve growth factor-dependent sensory neurons. (PMID: 11161467) Friedel RH … Schnürch H (Molecular and cellular neurosciences 2001) 2 3 60
  4. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2016) 3 60
  5. Sequence-structure based phylogeny of GPCR Class A Rhodopsin receptors. (PMID: 24503482) Kakarala KK … Jamil K (Molecular phylogenetics and evolution 2014) 3 60

Products for GPR149 Gene

Sources for GPR149 Gene

Content
Loading form....