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Aliases for GPR149 Gene

Aliases for GPR149 Gene

  • G Protein-Coupled Receptor 149 2 3 5
  • G-Protein Coupled Receptor PGR10 3 4
  • PGR10 3 4
  • G Protein-Coupled Receptor PGR10 3
  • IEDA 3

External Ids for GPR149 Gene

Previous GeneCards Identifiers for GPR149 Gene

  • GC03M155376
  • GC03M155538
  • GC03M154055
  • GC03M151450

Summaries for GPR149 Gene

GeneCards Summary for GPR149 Gene

GPR149 (G Protein-Coupled Receptor 149) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity and neuropeptide binding.

UniProtKB/Swiss-Prot for GPR149 Gene

  • Orphan receptor.

Gene Wiki entry for GPR149 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR149 Gene

Genomics for GPR149 Gene

Regulatory Elements for GPR149 Gene

Enhancers for GPR149 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPR149 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR149 Gene

Chromosome:
3
Start:
154,337,672 bp from pter
End:
154,429,715 bp from pter
Size:
92,044 bases
Orientation:
Minus strand

Genomic View for GPR149 Gene

Genes around GPR149 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR149 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR149 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR149 Gene

Proteins for GPR149 Gene

  • Protein details for GPR149 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SP6-GP149_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 149
    Protein Accession:
    Q86SP6

    Protein attributes for GPR149 Gene

    Size:
    731 amino acids
    Molecular mass:
    80984 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR149 Gene

Proteomics data for GPR149 Gene at MOPED

Post-translational modifications for GPR149 Gene

  • Glycosylation at Asn 7, Asn 11, and Asn 21
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR149 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GPR149 Gene

Domains & Families for GPR149 Gene

Gene Families for GPR149 Gene

Protein Domains for GPR149 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR149 Gene

Graphical View of Domain Structure for InterPro Entry

Q86SP6

UniProtKB/Swiss-Prot:

GP149_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR149: view

Function for GPR149 Gene

Molecular function for GPR149 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Gene Ontology (GO) - Molecular Function for GPR149 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042923 neuropeptide binding IBA --
genes like me logo Genes that share ontologies with GPR149: view
genes like me logo Genes that share phenotypes with GPR149: view

Animal Models for GPR149 Gene

MGI Knock Outs for GPR149:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR149

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GPR149 Gene

Localization for GPR149 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR149 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR149 Gene COMPARTMENTS Subcellular localization image for GPR149 gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for GPR149 Gene

Pathways & Interactions for GPR149 Gene

SuperPathways for GPR149 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPR149 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001546 preantral ovarian follicle growth IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR149: view

No data available for Pathways by source and SIGNOR curated interactions for GPR149 Gene

Drugs & Compounds for GPR149 Gene

No Compound Related Data Available

Transcripts for GPR149 Gene

mRNA/cDNA for GPR149 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR149 Gene

G protein-coupled receptor 149:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR149 Gene

No ASD Table

Relevant External Links for GPR149 Gene

GeneLoc Exon Structure for
GPR149
ECgene alternative splicing isoforms for
GPR149

Expression for GPR149 Gene

mRNA expression in normal human tissues for GPR149 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR149 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x16.9), Brain - Caudate (basal ganglia) (x10.0), Brain - Putamen (basal ganglia) (x8.6), Pituitary (x4.9), and Brain - Hypothalamus (x4.4).

Protein differential expression in normal tissues from HIPED for GPR149 Gene

This gene is overexpressed in Pancreatic juice (44.0) and Peripheral blood mononuclear cells (25.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR149 Gene



SOURCE GeneReport for Unigene cluster for GPR149 Gene Hs.688231

genes like me logo Genes that share expression patterns with GPR149: view

Protein tissue co-expression partners for GPR149 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for GPR149 Gene

Orthologs for GPR149 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR149 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPR149 35
  • 88.39 (n)
  • 85.6 (a)
GPR149 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPR149 35
  • 84.19 (n)
  • 81.74 (a)
GPR149 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr149 35
  • 82.26 (n)
  • 79.42 (a)
Gpr149 16
Gpr149 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPR149 35
  • 99.5 (n)
  • 99.59 (a)
GPR149 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr149 35
  • 81.53 (n)
  • 78.74 (a)
oppossum
(Monodelphis domestica)
Mammalia GPR149 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR149 36
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR149 35
  • 65.4 (n)
  • 62.22 (a)
GPR149 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR149 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr149 35
  • 64.87 (n)
  • 60.99 (a)
Species with no ortholog for GPR149:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GPR149 Gene

ENSEMBL:
Gene Tree for GPR149 (if available)
TreeFam:
Gene Tree for GPR149 (if available)

Paralogs for GPR149 Gene

No data available for Paralogs for GPR149 Gene

Variants for GPR149 Gene

Sequence variations from dbSNP and Humsavar for GPR149 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1848952 -- 154,370,962(-) atagg(A/T)aattt intron-variant
rs1067574 -- 154,356,733(+) atcaa(C/T)attgt intron-variant
rs1086054 -- 154,371,164(-) ctaaa(A/C/T)cttga intron-variant
rs1086055 -- 154,371,077(-) aagtg(C/G)tgggg intron-variant
rs1086056 -- 154,370,622(-) ggcac(A/C)ttcag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR149 Gene

Variant ID Type Subtype PubMed ID
nsv4073 CNV Insertion 18451855
esv2640775 CNV Deletion 19546169
esv1948933 CNV Deletion 18987734
esv2726081 CNV Deletion 23290073
esv1340831 CNV Deletion 17803354
esv5849 CNV Loss 19470904

Variation tolerance for GPR149 Gene

Residual Variation Intolerance Score: 11.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.40; 42.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR149 Gene

Human Gene Mutation Database (HGMD)
GPR149

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR149 Gene

Disorders for GPR149 Gene

Relevant External Links for GPR149

Genetic Association Database (GAD)
GPR149
Human Genome Epidemiology (HuGE) Navigator
GPR149
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR149

No disorders were found for GPR149 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR149 Gene

Publications for GPR149 Gene

  1. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis D.K. … Gaitanaris G.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4 67
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for GPR149 Gene

Sources for GPR149 Gene

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