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Aliases for GPR148 Gene

Aliases for GPR148 Gene

  • G Protein-Coupled Receptor 148 2 3 5
  • Brain And Testis Restricted GPCR 3 4
  • PGR6 3 4
  • BTR 3 4
  • Probable G-Protein Coupled Receptor 148 3
  • G Protein-Coupled Receptor PGR6 3
  • G-Protein Coupled Receptor PGR6 4

External Ids for GPR148 Gene

Previous GeneCards Identifiers for GPR148 Gene

  • GC02P131697
  • GC02P131320
  • GC02P131203
  • GC02P131486
  • GC02P123559
  • GC02P130729
  • GC02P130730
  • GC02P130820
  • GC02P130850

Summaries for GPR148 Gene

GeneCards Summary for GPR148 Gene

GPR148 (G Protein-Coupled Receptor 148) is a Protein Coding gene. Diseases associated with GPR148 include Cicatricial Entropion and Median Neuropathy. GO annotations related to this gene include G-protein coupled receptor activity.

UniProtKB/Swiss-Prot for GPR148 Gene

  • Orphan receptor.

Gene Wiki entry for GPR148 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR148 Gene

Genomics for GPR148 Gene

Regulatory Elements for GPR148 Gene

Enhancers for GPR148 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F130823 1.1 Ensembl ENCODE 10.9 +96.4 96431 1.9 HDGF JUN BMI1 EBF1 RELA EED ZNF207 ETV6 FOS CREM GPR148 ARHGEF4 MZT2B CCDC74A CYCSP8
GH02F130819 0.8 Ensembl ENCODE 10.9 +92.3 92252 1.2 CTCF REST ZIC2 ZNF652 GPR148 ARHGEF4 CYCSP8
GH02F130824 0.6 FANTOM5 10.9 +95.1 95130 0.3 SMARCA4 MTA2 TBX21 GPR148 ARHGEF4 CYCSP8
GH02F130726 1.2 Ensembl ENCODE 0.8 -0.5 -473 2.6 ATF1 PKNOX1 SIN3A ZBTB40 CREM EGR2 SP3 CEBPB ZHX2 ELF1 GC02M130719 GPR148
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPR148 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR148 Gene

130,728,156 bp from pter
130,730,544 bp from pter
2,389 bases
Plus strand

Genomic View for GPR148 Gene

Genes around GPR148 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR148 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR148 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR148 Gene

Proteins for GPR148 Gene

  • Protein details for GPR148 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 148
    Protein Accession:
    Secondary Accessions:
    • Q2M369
    • Q86SP7
    • Q86U87

    Protein attributes for GPR148 Gene

    347 amino acids
    Molecular mass:
    38288 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR148 Gene

Post-translational modifications for GPR148 Gene

  • Glycosylation at Asn 34
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR148 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR148 Gene

Domains & Families for GPR148 Gene

Gene Families for GPR148 Gene

Protein Domains for GPR148 Gene

Suggested Antigen Peptide Sequences for GPR148 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR148: view

Function for GPR148 Gene

Molecular function for GPR148 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Gene Ontology (GO) - Molecular Function for GPR148 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GPR148: view

Phenotypes for GPR148 Gene

genes like me logo Genes that share phenotypes with GPR148: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GPR148 Gene

Localization for GPR148 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR148 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR148 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for GPR148 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR148: view

Pathways & Interactions for GPR148 Gene

SuperPathways for GPR148 Gene

No Data Available

Interacting Proteins for GPR148 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000308908 for GPR148 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for GPR148 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR148: view

No data available for Pathways by source and SIGNOR curated interactions for GPR148 Gene

Transcripts for GPR148 Gene

mRNA/cDNA for GPR148 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR148 Gene

No ASD Table

Relevant External Links for GPR148 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR148 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR148 Gene

mRNA differential expression in normal tissues according to GTEx for GPR148 Gene

This gene is overexpressed in Pituitary (x11.0), Brain - Cerebellar Hemisphere (x8.0), and Brain - Cerebellum (x7.8).

Protein differential expression in normal tissues from HIPED for GPR148 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR148 Gene

Protein tissue co-expression partners for GPR148 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPR148 Gene:


SOURCE GeneReport for Unigene cluster for GPR148 Gene:


mRNA Expression by UniProt/SwissProt for GPR148 Gene:

Tissue specificity: Expression restricted to nervous system and testis. Is also detected in several tumors types, most notably prostate cancer.
genes like me logo Genes that share expression patterns with GPR148: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GPR148 Gene

Orthologs for GPR148 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR148 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR148 34 35
  • 99.04 (n)
(Canis familiaris)
Mammalia GPR148 34
  • 75.6 (n)
(Ornithorhynchus anatinus)
Mammalia GPR148 35
  • 52 (a)
(Monodelphis domestica)
Mammalia GPR148 35
  • 51 (a)
(Danio rerio)
Actinopterygii LOC101885431 34
  • 46.6 (n)
BX323035.1 35
  • 28 (a)
Species where no ortholog for GPR148 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR148 Gene

Gene Tree for GPR148 (if available)
Gene Tree for GPR148 (if available)

Paralogs for GPR148 Gene

No data available for Paralogs for GPR148 Gene

Variants for GPR148 Gene

Sequence variations from dbSNP and Humsavar for GPR148 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10682124 -- 130,730,805(+) AAGAA(-/GAA)AATTC intron-variant, downstream-variant-500B
rs112230929 -- 130,730,400(+) GGAAA(C/T)GGAAG intron-variant, downstream-variant-500B
rs112764370 -- 130,730,314(+) CTTTC(A/G)GAAGA intron-variant, utr-variant-3-prime
rs113110453 -- 130,729,924(+) TTCCC(A/G)GGCCA intron-variant, reference, missense
rs114163212 -- 130,728,555(+) GGAGC(C/T)CTGAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GPR148 Gene

Variant ID Type Subtype PubMed ID
nsv7327 OTHER inversion 18451855
nsv583136 CNV loss 21841781
nsv583135 CNV loss 21841781
nsv524021 CNV loss 19592680
nsv428403 CNV loss 18775914
nsv1147463 OTHER inversion 26484159
nsv1014723 CNV loss 25217958
esv3893337 CNV loss 25118596
esv3575299 CNV gain 25503493
esv2760576 CNV gain+loss 21179565
esv2759092 CNV gain+loss 17122850
esv2670824 CNV deletion 23128226
dgv731e199 CNV deletion 23128226
dgv616e201 CNV deletion 23290073
dgv4075n100 CNV gain 25217958
dgv4074n100 CNV gain 25217958
dgv2032n106 OTHER inversion 24896259

Variation tolerance for GPR148 Gene

Residual Variation Intolerance Score: 90% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.37; 63.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR148 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR148 Gene

Disorders for GPR148 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GPR148 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cicatricial entropion
median neuropathy
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GPR148

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GPR148: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR148 Gene

Publications for GPR148 Gene

  1. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis D.K. … Gaitanaris G.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. A novel human G protein-coupled receptor is over-expressed in prostate cancer. (PMID: 15688318) Parmigiani R.B. … Malnic B. (Genet. Mol. Res. 2004) 3 4 64
  4. Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S. … Mitaku S. (FEBS Lett. 2002) 3 4 64
  5. Small rare recurrent deletions and reciprocal duplications in 2q21.1, including brain-specific ARHGEF4 and GPR148. (PMID: 22543972) Dharmadhikari A.V. … Stankiewicz P. (Hum. Mol. Genet. 2012) 3 64

Products for GPR148 Gene

Sources for GPR148 Gene

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