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Aliases for GPR148 Gene

Aliases for GPR148 Gene

  • G Protein-Coupled Receptor 148 2 3 5
  • Brain And Testis Restricted GPCR 3 4
  • G-Protein Coupled Receptor PGR6 3 4
  • PGR6 3 4
  • BTR 3 4
  • G Protein-Coupled Receptor PGR6 3

External Ids for GPR148 Gene

Previous GeneCards Identifiers for GPR148 Gene

  • GC02P131697
  • GC02P131320
  • GC02P131203
  • GC02P131486
  • GC02P123559
  • GC02P130729
  • GC02P130730

Summaries for GPR148 Gene

GeneCards Summary for GPR148 Gene

GPR148 (G Protein-Coupled Receptor 148) is a Protein Coding gene. Diseases associated with GPR148 include Cicatricial Entropion and Median Neuropathy. GO annotations related to this gene include G-protein coupled receptor activity.

UniProtKB/Swiss-Prot for GPR148 Gene

  • Orphan receptor.

Gene Wiki entry for GPR148 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR148 Gene

Genomics for GPR148 Gene

Regulatory Elements for GPR148 Gene

Enhancers for GPR148 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPR148 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR148 Gene

130,728,156 bp from pter
130,730,544 bp from pter
2,389 bases
Plus strand

Genomic View for GPR148 Gene

Genes around GPR148 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR148 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR148 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR148 Gene

Proteins for GPR148 Gene

  • Protein details for GPR148 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 148
    Protein Accession:
    Secondary Accessions:
    • Q2M369
    • Q86SP7
    • Q86U87

    Protein attributes for GPR148 Gene

    347 amino acids
    Molecular mass:
    38288 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR148 Gene

Proteomics data for GPR148 Gene at MOPED

Post-translational modifications for GPR148 Gene

  • Glycosylation at Asn 34
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR148 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR148 Gene

Domains & Families for GPR148 Gene

Gene Families for GPR148 Gene

Protein Domains for GPR148 Gene


Suggested Antigen Peptide Sequences for GPR148 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR148: view

Function for GPR148 Gene

Molecular function for GPR148 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Phenotypes for GPR148 Gene

GenomeRNAi human phenotypes for GPR148:
genes like me logo Genes that share phenotypes with GPR148: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GPR148 Gene

Localization for GPR148 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR148 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GPR148 Gene COMPARTMENTS Subcellular localization image for GPR148 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for GPR148 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with GPR148: view

Pathways & Interactions for GPR148 Gene

SuperPathways for GPR148 Gene

No Data Available

Interacting Proteins for GPR148 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000308908 for GPR148 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for GPR148 Gene


No data available for Pathways by source and SIGNOR curated interactions for GPR148 Gene

Drugs & Compounds for GPR148 Gene

No Compound Related Data Available

Transcripts for GPR148 Gene

mRNA/cDNA for GPR148 Gene

(3) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for GPR148 Gene

No ASD Table

Relevant External Links for GPR148 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR148 Gene

mRNA expression in normal human tissues for GPR148 Gene

mRNA differential expression in normal tissues according to GTEx for GPR148 Gene

This gene is overexpressed in Pituitary (x11.0), Brain - Cerebellar Hemisphere (x8.0), and Brain - Cerebellum (x7.8).

Protein differential expression in normal tissues from HIPED for GPR148 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR148 Gene

SOURCE GeneReport for Unigene cluster for GPR148 Gene Hs.452574

mRNA Expression by UniProt/SwissProt for GPR148 Gene

Tissue specificity: Expression restricted to nervous system and testis. Is also detected in several tumors types, most notably prostate cancer.
genes like me logo Genes that share expression patterns with GPR148: view

Protein tissue co-expression partners for GPR148 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GPR148 Gene

Orthologs for GPR148 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR148 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia GPR148 35
  • 75.6 (n)
  • 65.22 (a)
(Pan troglodytes)
Mammalia GPR148 35
  • 99.04 (n)
  • 98.85 (a)
GPR148 36
  • 99 (a)
(Monodelphis domestica)
Mammalia GPR148 36
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia GPR148 36
  • 52 (a)
(Danio rerio)
Actinopterygii LOC101885431 35
  • 46.6 (n)
  • 33.8 (a)
BX323035.1 36
  • 28 (a)
Species with no ortholog for GPR148:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR148 Gene

Gene Tree for GPR148 (if available)
Gene Tree for GPR148 (if available)

Paralogs for GPR148 Gene

No data available for Paralogs for GPR148 Gene

Variants for GPR148 Gene

Sequence variations from dbSNP and Humsavar for GPR148 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs272128 - 130,730,100(-) GTATG(G/T)GAGCA reference, missense
rs2929893 -- 130,727,025(-) CCTAA(A/G)GGAAC upstream-variant-2KB
rs11894380 -- 130,730,324(+) ACCTC(A/C)ACTGA utr-variant-3-prime
rs7559109 -- 130,728,596(+) CATGC(A/C)CAGGG intron-variant, upstream-variant-2KB
rs7560483 -- 130,730,783(+) TTGAC(A/T)TTCGT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for GPR148 Gene

Variant ID Type Subtype PubMed ID
dgv1247e1 CNV Complex 17122850
dgv1250e1 CNV Complex 17122850
nsv428403 CNV Loss 18775914
nsv7327 OTHER Inversion 18451855
esv2670824 CNV Deletion 23128226
nsv875104 CNV Loss 21882294
dgv659e201 CNV Deletion 23290073
dgv731e199 CNV Deletion 23128226
nsv524021 CNV Loss 19592680

Variation tolerance for GPR148 Gene

Residual Variation Intolerance Score: 90% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.37; 63.47% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GPR148 Gene

Disorders for GPR148 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GPR148 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cicatricial entropion
median neuropathy
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GPR148

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GPR148: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR148 Gene

Publications for GPR148 Gene

  1. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis D.K. … Gaitanaris G.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4 67
  2. Small rare recurrent deletions and reciprocal duplications in 2q21.1, including brain-specific ARHGEF4 and GPR148. (PMID: 22543972) Dharmadhikari A.V. … Stankiewicz P. (Hum. Mol. Genet. 2012) 3
  3. Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship. (PMID: 15777626) Gloriam D.E. … Fredriksson R. (Biochim. Biophys. Acta 2005) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  5. A novel human G protein-coupled receptor is over-expressed in prostate cancer. (PMID: 15688318) Parmigiani R.B. … Malnic B. (Genet. Mol. Res. 2004) 3

Products for GPR148 Gene

Sources for GPR148 Gene