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Aliases for GPR146 Gene

Aliases for GPR146 Gene

  • G Protein-Coupled Receptor 146 2 3 5
  • G-Protein Coupled Receptor PGR8 3 4
  • PGR8 3 4
  • Probable G-Protein Coupled Receptor 146 3

External Ids for GPR146 Gene

Previous GeneCards Identifiers for GPR146 Gene

  • GC07P000807
  • GC07P000841
  • GC07P000871
  • GC07P001050
  • GC07P001061
  • GC07P001084
  • GC07P001012

Summaries for GPR146 Gene

GeneCards Summary for GPR146 Gene

GPR146 (G Protein-Coupled Receptor 146) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPER1.

UniProtKB/Swiss-Prot for GPR146 Gene

  • Orphan receptor.

Gene Wiki entry for GPR146 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR146 Gene

Genomics for GPR146 Gene

Regulatory Elements for GPR146 Gene

Enhancers for GPR146 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F000981 1.1 Ensembl ENCODE 22.2 -59.0 -58999 7.7 HDGF PKNOX1 ARNT MLX CREB3L1 ARID4B SIN3A DMAP1 YBX1 YY1 CYP2W1 LOC105375120 GPR146 MIR339 ADAP1 COX19 ENSG00000225146 C7orf50 LOC101927021 GC07M001007
GH07F000971 1.2 FANTOM5 ENCODE 20.6 -68.3 -68330 8.8 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CYP2W1 LOC105375120 GPR146 MIR339 ADAP1 ENSG00000225146 C7orf50 MAFK COX19 LOC101927021
GH07F001122 0.8 Ensembl ENCODE 16.3 +79.6 79630 3.2 CTCF TEAD4 REST RAD21 NR2F2 TEAD3 OSR2 SMC3 ZBTB33 ZNF600 LOC101927021 GPR146 LOC105375120 ZFAND2A CYP2W1 ENSG00000225146 MIR339 GPER1 LOC102723758 PIR49984
GH07F001078 0.4 ENCODE 12.5 +34.2 34190 0.5 SOX13 ZGPAT GATAD1 SP5 ETV4 ARID4B NR2F6 MAFK RARA RXRB LOC101927021 GPR146 ENSG00000225146 C7orf50 ZFAND2A ADAP1 GPER1 ENSG00000226291 LOC105375120
GH07F001095 0.6 Ensembl ENCODE 11.7 +51.6 51602 1.0 ZNF687 RFX1 BHLHE40 SIN3A MNT YY1 E2F1 GATA3 HNF4G NR2F6 LOC105375120 C7orf50 GPR146 ENSG00000225146 LOC101927021 PIR42335 PIR59593
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GPR146 on UCSC Golden Path with GeneCards custom track

Promoters for GPR146 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000156362 27 1201 ARID4B SIN3A BRCA1 YY1 GLIS2 SP3 NCOA1 REST PPARG KAT8

Genomic Location for GPR146 Gene

Chromosome:
7
Start:
1,044,573 bp from pter
End:
1,059,269 bp from pter
Size:
14,697 bases
Orientation:
Plus strand

Genomic View for GPR146 Gene

Genes around GPR146 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR146 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR146 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR146 Gene

Proteins for GPR146 Gene

  • Protein details for GPR146 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CH1-GP146_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 146
    Protein Accession:
    Q96CH1
    Secondary Accessions:
    • Q86SP5

    Protein attributes for GPR146 Gene

    Size:
    333 amino acids
    Molecular mass:
    36580 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR146 Gene

Post-translational modifications for GPR146 Gene

  • Glycosylation at Asn 8
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPR146 Gene

Domains & Families for GPR146 Gene

Gene Families for GPR146 Gene

Protein Domains for GPR146 Gene

Graphical View of Domain Structure for InterPro Entry

Q96CH1

UniProtKB/Swiss-Prot:

GP146_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR146: view

Function for GPR146 Gene

Molecular function for GPR146 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Gene Ontology (GO) - Molecular Function for GPR146 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GPR146: view
genes like me logo Genes that share phenotypes with GPR146: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR146

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR146 Gene

Localization for GPR146 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR146 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR146 Gene COMPARTMENTS Subcellular localization image for GPR146 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR146 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR146: view

Pathways & Interactions for GPR146 Gene

SuperPathways for GPR146 Gene

No Data Available

Interacting Proteins for GPR146 Gene

Gene Ontology (GO) - Biological Process for GPR146 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR146: view

No data available for Pathways by source and SIGNOR curated interactions for GPR146 Gene

Transcripts for GPR146 Gene

Unigene Clusters for GPR146 Gene

G protein-coupled receptor 146:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR146 Gene

No ASD Table

Relevant External Links for GPR146 Gene

GeneLoc Exon Structure for
GPR146
ECgene alternative splicing isoforms for
GPR146

Expression for GPR146 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR146 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of GPR146 Gene:

GPR146

SOURCE GeneReport for Unigene cluster for GPR146 Gene:

Hs.718624
genes like me logo Genes that share expression patterns with GPR146: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for GPR146 Gene

Orthologs for GPR146 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR146 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia GPR146 34 35
  • 77.58 (n)
mouse
(Mus musculus)
Mammalia Gpr146 34 16 35
  • 77.34 (n)
rat
(Rattus norvegicus)
Mammalia Gpr146 34
  • 76.03 (n)
cow
(Bos Taurus)
Mammalia GPR146 34 35
  • 75.68 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR146 35
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR146 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR146 34 35
  • 66.17 (n)
lizard
(Anolis carolinensis)
Reptilia GPR146 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr146 34
  • 63.86 (n)
zebrafish
(Danio rerio)
Actinopterygii gpr146 34 35
  • 66.77 (n)
Species where no ortholog for GPR146 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR146 Gene

ENSEMBL:
Gene Tree for GPR146 (if available)
TreeFam:
Gene Tree for GPR146 (if available)

Paralogs for GPR146 Gene

Paralogs for GPR146 Gene

genes like me logo Genes that share paralogs with GPR146: view

Variants for GPR146 Gene

Sequence variations from dbSNP and Humsavar for GPR146 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10247470 -- 1,052,876(+) AGCCT(C/G)CAGAA intron-variant, upstream-variant-2KB
rs10251493 -- 1,053,774(+) GTGAG(C/T)TGAGA intron-variant, upstream-variant-2KB
rs10253875 -- 1,053,353(+) GCAGG(A/G)CAGGA intron-variant, upstream-variant-2KB
rs10257328 -- 1,053,250(+) CTGCG(G/T)CCAGG intron-variant, upstream-variant-2KB
rs10270216 -- 1,047,213(+) AGCCC(A/G)CTCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR146 Gene

Variant ID Type Subtype PubMed ID
nsv1161477 CNV deletion 26073780
nsv464245 CNV gain 19166990
nsv509183 CNV insertion 20534489
nsv605699 CNV loss 21841781
nsv605700 CNV gain 21841781
nsv605705 CNV loss 21841781
nsv605720 CNV loss 21841781
nsv823960 CNV gain 20364138
nsv950784 CNV deletion 24416366

Variation tolerance for GPR146 Gene

Residual Variation Intolerance Score: 56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.76; 47.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR146 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR146

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR146 Gene

Disorders for GPR146 Gene

Relevant External Links for GPR146

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR146

No disorders were found for GPR146 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR146 Gene

Publications for GPR146 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis D.K. … Gaitanaris G.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 64
  3. Evidence for an interaction between proinsulin C-peptide and GPR146. (PMID: 23980258) Yosten G.L. … Samson W.K. (J. Endocrinol. 2013) 3 64
  4. Discovery and refinement of loci associated with lipid levels. (PMID: 24097068) . … Abecasis G.R. (Nat. Genet. 2013) 3 64
  5. Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship. (PMID: 15777626) Gloriam D.E. … Fredriksson R. (Biochim. Biophys. Acta 2005) 3 64

Products for GPR146 Gene

Sources for GPR146 Gene

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