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Aliases for GPR146 Gene

Aliases for GPR146 Gene

  • G Protein-Coupled Receptor 146 2 3 5
  • G-Protein Coupled Receptor PGR8 3 4
  • PGR8 3 4

External Ids for GPR146 Gene

Previous GeneCards Identifiers for GPR146 Gene

  • GC07P000807
  • GC07P000841
  • GC07P000871
  • GC07P001050
  • GC07P001061
  • GC07P001084
  • GC07P001012

Summaries for GPR146 Gene

GeneCards Summary for GPR146 Gene

GPR146 (G Protein-Coupled Receptor 146) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPER1.

UniProtKB/Swiss-Prot for GPR146 Gene

  • Orphan receptor.

Gene Wiki entry for GPR146 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR146 Gene

Genomics for GPR146 Gene

Regulatory Elements for GPR146 Gene

Enhancers for GPR146 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPR146 on UCSC Golden Path with GeneCards custom track

Promoters for GPR146 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPR146 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR146 Gene

1,044,573 bp from pter
1,059,269 bp from pter
14,697 bases
Plus strand

Genomic View for GPR146 Gene

Genes around GPR146 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR146 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR146 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR146 Gene

Proteins for GPR146 Gene

  • Protein details for GPR146 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 146
    Protein Accession:
    Secondary Accessions:
    • Q86SP5

    Protein attributes for GPR146 Gene

    333 amino acids
    Molecular mass:
    36580 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR146 Gene

Proteomics data for GPR146 Gene at MOPED

Post-translational modifications for GPR146 Gene

  • Glycosylation at Asn 8
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR146 Gene

No data available for DME Specific Peptides for GPR146 Gene

Domains & Families for GPR146 Gene

Gene Families for GPR146 Gene

Protein Domains for GPR146 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR146: view

Function for GPR146 Gene

Molecular function for GPR146 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.
genes like me logo Genes that share phenotypes with GPR146: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR146

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR146 Gene

Localization for GPR146 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR146 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GPR146 Gene COMPARTMENTS Subcellular localization image for GPR146 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR146 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with GPR146: view

Pathways & Interactions for GPR146 Gene

SuperPathways for GPR146 Gene

No Data Available

Interacting Proteins for GPR146 Gene

Gene Ontology (GO) - Biological Process for GPR146 Gene


No data available for Pathways by source and SIGNOR curated interactions for GPR146 Gene

Drugs & Compounds for GPR146 Gene

No Compound Related Data Available

Transcripts for GPR146 Gene

Unigene Clusters for GPR146 Gene

G protein-coupled receptor 146:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR146 Gene

No ASD Table

Relevant External Links for GPR146 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR146 Gene

mRNA expression in normal human tissues for GPR146 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for GPR146 Gene Hs.718624

genes like me logo Genes that share expression patterns with GPR146: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GPR146 Gene

Orthologs for GPR146 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR146 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPR146 35
  • 75.68 (n)
  • 66.57 (a)
GPR146 36
  • 66 (a)
(Canis familiaris)
Mammalia GPR146 35
  • 77.58 (n)
  • 73.27 (a)
GPR146 36
  • 73 (a)
(Mus musculus)
Mammalia Gpr146 35
  • 77.34 (n)
  • 74.92 (a)
Gpr146 16
Gpr146 36
  • 74 (a)
(Rattus norvegicus)
Mammalia Gpr146 35
  • 76.03 (n)
  • 75.23 (a)
(Monodelphis domestica)
Mammalia GPR146 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia GPR146 36
  • 66 (a)
(Gallus gallus)
Aves GPR146 35
  • 66.17 (n)
  • 64.56 (a)
GPR146 36
  • 65 (a)
(Anolis carolinensis)
Reptilia GPR146 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr146 35
  • 63.86 (n)
  • 60.96 (a)
(Danio rerio)
Actinopterygii gpr146 35
  • 66.77 (n)
  • 61.86 (a)
gpr146 36
  • 62 (a)
Species with no ortholog for GPR146:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR146 Gene

Gene Tree for GPR146 (if available)
Gene Tree for GPR146 (if available)

Paralogs for GPR146 Gene

Paralogs for GPR146 Gene

genes like me logo Genes that share paralogs with GPR146: view

Variants for GPR146 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPR146 Gene

Variant ID Type Subtype PubMed ID
dgv7074n71 CNV Loss 21882294
nsv887128 CNV Loss 21882294
dgv7080n71 CNV Loss 21882294
nsv464245 CNV Gain 19166990
nsv887141 CNV Loss 21882294
dgv7081n71 CNV Loss 21882294
dgv7082n71 CNV Loss 21882294
dgv7083n71 CNV Loss 21882294
dgv7084n71 CNV Loss 21882294
dgv7085n71 CNV Loss 21882294
nsv887158 CNV Loss 21882294
dgv7087n71 CNV Loss 21882294
nsv509183 CNV Insertion 20534489
nsv823960 CNV Gain 20364138

Variation tolerance for GPR146 Gene

Residual Variation Intolerance Score: 56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.76; 47.03% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for GPR146 Gene

Disorders for GPR146 Gene

Relevant External Links for GPR146

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GPR146 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR146 Gene

Publications for GPR146 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Evidence for an interaction between proinsulin C-peptide and GPR146. (PMID: 23980258) Yosten G.L. … Samson W.K. (J. Endocrinol. 2013) 3
  3. Discovery and refinement of loci associated with lipid levels. (PMID: 24097068) . … Abecasis G.R. (Nat. Genet. 2013) 3
  4. Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship. (PMID: 15777626) Gloriam D.E. … Fredriksson R. (Biochim. Biophys. Acta 2005) 3
  5. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis D.K. … Gaitanaris G.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3

Products for GPR146 Gene

Sources for GPR146 Gene