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Aliases for GPR142 Gene

Aliases for GPR142 Gene

  • G Protein-Coupled Receptor 142 2 3 5
  • G-Protein Coupled Receptor PGR2 3 4
  • PGR2 3 4
  • G-Protein Coupled Receptor 142 Long Form 3
  • Probable G-Protein Coupled Receptor 142 3
  • GPRg1b 3

External Ids for GPR142 Gene

Previous GeneCards Identifiers for GPR142 Gene

  • GC17P072829
  • GC17P072919
  • GC17P069875
  • GC17P072322
  • GC17P072363

Summaries for GPR142 Gene

Entrez Gene Summary for GPR142 Gene

  • GPR142 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008]

GeneCards Summary for GPR142 Gene

GPR142 (G Protein-Coupled Receptor 142) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR139.

UniProtKB/Swiss-Prot for GPR142 Gene

  • Orphan receptor.

Gene Wiki entry for GPR142 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR142 Gene

Genomics for GPR142 Gene

Regulatory Elements for GPR142 Gene

Enhancers for GPR142 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F074461 1.5 FANTOM5 ENCODE 12.3 +98.4 98363 9.3 HDGF PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A YBX1 ZNF207 FOS KLF13 NAT9 CD300A GPR142 CD300LB NUP85 BTBD17 CD300C CD300E CD300LF CD300LD
GH17F074457 1.4 FANTOM5 Ensembl ENCODE 12.3 +90.3 90263 0.7 HDGF ARID4B ZNF48 ZSCAN9 ZNF2 RAD21 YY1 GLIS2 ZNF143 MIXL1 GPR142 RAB37 GRIN2C TTYH2 GPRC5C CD300A GC17P074445
GH17F074394 1.3 FANTOM5 Ensembl ENCODE 12.9 +27.8 27761 1.9 ZIC2 ZNF316 GATA3 ZFHX2 POLR2A NFE2 FOSL2 FOS MAFK EGR2 RAB37 GPR142 GPRC5C CD300A CD300E CD300LD GRIN2C FADS6 GC17M074418 RNA5SP448
GH17F074442 1.3 Ensembl ENCODE 12.4 +77.7 77653 5.7 PKNOX1 MLX ARID4B DMAP1 YY1 SLC30A9 SP3 SP5 ZHX2 MXD4 GPRC5C CD300A GPR142 CD300E CD300LD NT5C GC17M074409 GC17P074445
GH17F074451 1.3 Ensembl ENCODE 12.4 +86.5 86511 4.1 ATF1 ARID4B SIN3A ZNF48 YY1 ZNF121 GLIS2 ZNF143 KLF7 SP3 GPR142 CD300E CD300LD GPRC5C ENSG00000265800 GC17P074445 CD300A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPR142 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR142 Gene

74,367,407 bp from pter
74,373,008 bp from pter
5,602 bases
Plus strand

Genomic View for GPR142 Gene

Genes around GPR142 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR142 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR142 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR142 Gene

Proteins for GPR142 Gene

  • Protein details for GPR142 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 142
    Protein Accession:
    Secondary Accessions:
    • A4CYJ8
    • Q86SL3

    Protein attributes for GPR142 Gene

    462 amino acids
    Molecular mass:
    51106 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR142 Gene

Post-translational modifications for GPR142 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPR142 Gene

No data available for DME Specific Peptides for GPR142 Gene

Domains & Families for GPR142 Gene

Gene Families for GPR142 Gene

Protein Domains for GPR142 Gene

Suggested Antigen Peptide Sequences for GPR142 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR142: view

Function for GPR142 Gene

Molecular function for GPR142 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Gene Ontology (GO) - Molecular Function for GPR142 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GPR142: view
genes like me logo Genes that share phenotypes with GPR142: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR142

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GPR142 Gene

Localization for GPR142 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR142 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR142 gene
Compartment Confidence
plasma membrane 5
cytosol 4
lysosome 1

Gene Ontology (GO) - Cellular Components for GPR142 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IDA --
genes like me logo Genes that share ontologies with GPR142: view

Pathways & Interactions for GPR142 Gene

SuperPathways for GPR142 Gene

No Data Available

Interacting Proteins for GPR142 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q7Z601-GP142_HUMAN ENSP00000335158 for GPR142 Gene via IID STRING

Gene Ontology (GO) - Biological Process for GPR142 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR142: view

No data available for Pathways by source and SIGNOR curated interactions for GPR142 Gene

Transcripts for GPR142 Gene

mRNA/cDNA for GPR142 Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR142 Gene

G protein-coupled receptor 142:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR142 Gene

No ASD Table

Relevant External Links for GPR142 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR142 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR142 Gene

mRNA differential expression in normal tissues according to GTEx for GPR142 Gene

This gene is overexpressed in Spleen (x6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR142 Gene

Protein tissue co-expression partners for GPR142 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPR142 Gene:


SOURCE GeneReport for Unigene cluster for GPR142 Gene:


mRNA Expression by UniProt/SwissProt for GPR142 Gene:

Tissue specificity: Exclusively expressed in the central nervous system, most abundantly in the ventrolateral region of caudate putamen, the habenular nucleus, the zona incerta, and the medial mammillary nucleus.
genes like me logo Genes that share expression patterns with GPR142: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein differential expression in normal tissues for GPR142 Gene

Orthologs for GPR142 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR142 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR142 34 35
  • 96.64 (n)
(Canis familiaris)
Mammalia GPR142 34 35
  • 85.36 (n)
(Bos Taurus)
Mammalia GPR142 34 35
  • 84.23 (n)
(Rattus norvegicus)
Mammalia Gpr142 34
  • 81.38 (n)
(Mus musculus)
Mammalia Gpr142 34 16 35
  • 79.2 (n)
(Ornithorhynchus anatinus)
Mammalia GPR142 35
  • 66 (a)
(Gallus gallus)
Aves GPR142 34 35
  • 72.41 (n)
(Anolis carolinensis)
Reptilia GPR142 35
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr142 34
  • 60.72 (n)
(Danio rerio)
Actinopterygii LOC100000501 34
  • 60.85 (n)
gpr142 35
  • 45 (a)
Species where no ortholog for GPR142 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR142 Gene

Gene Tree for GPR142 (if available)
Gene Tree for GPR142 (if available)

Paralogs for GPR142 Gene

Paralogs for GPR142 Gene

(1) SIMAP similar genes for GPR142 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GPR142: view

Variants for GPR142 Gene

Sequence variations from dbSNP and Humsavar for GPR142 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs111235248 -- 74,371,405(+) CTGCT(C/T)GCCTT intron-variant
rs111310549 -- 74,370,404(+) GTCTG(A/C)CTAGA intron-variant
rs111469849 -- 74,370,462(+) GGCTG(C/T)GCCCA intron-variant
rs111668059 -- 74,371,970(+) CTCAC(A/G/T)GTTGA reference, synonymous-codon
rs111722967 -- 74,371,757(+) CTGGC(A/G)CGCCT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for GPR142 Gene

Variant ID Type Subtype PubMed ID
esv2761978 CNV gain 21179565
esv33995 CNV loss 17666407
esv2751770 CNV gain 17911159
dgv5768n54 CNV gain 21841781
dgv372n27 CNV gain 19166990
dgv3282n100 CNV gain 25217958
dgv12e196 CNV duplication 17116639
nsv833539 CNV loss 17160897
nsv833538 CNV gain 17160897
nsv517569 CNV gain+loss 19592680
nsv509673 CNV insertion 20534489
esv3641237 CNV gain 21293372
esv3641230 CNV gain 21293372
esv3573820 CNV gain 25503493

Variation tolerance for GPR142 Gene

Residual Variation Intolerance Score: 95.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.90; 67.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR142 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR142 Gene

Disorders for GPR142 Gene

Relevant External Links for GPR142

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GPR142 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR142 Gene

Publications for GPR142 Gene

  1. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. (PMID: 14623098) Fredriksson R. … Schioeth H.B. (FEBS Lett. 2003) 2 3 4 64
  2. Molecular cloning and characterization of a novel Gq-coupled orphan receptor GPRg1 exclusively expressed in the central nervous system. (PMID: 15845401) Matsuo A. … Shigeyoshi Y. (Biochem. Biophys. Res. Commun. 2005) 3 4 64
  3. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis D.K. … Gaitanaris G.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 64
  4. Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase. (PMID: 22889411) Guo Z. … Gao Y. (J. Proteome Res. 2012) 3 64
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 64

Products for GPR142 Gene

Sources for GPR142 Gene

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