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Aliases for GPR142 Gene

Aliases for GPR142 Gene

  • G Protein-Coupled Receptor 142 2 3
  • G-Protein Coupled Receptor PGR2 3 4
  • PGR2 3 4

External Ids for GPR142 Gene

Previous GeneCards Identifiers for GPR142 Gene

  • GC17P072829
  • GC17P072919
  • GC17P069875
  • GC17P072322
  • GC17P072363

Summaries for GPR142 Gene

Entrez Gene Summary for GPR142 Gene

  • GPR142 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008]

GeneCards Summary for GPR142 Gene

GPR142 (G Protein-Coupled Receptor 142) is a Protein Coding gene. Diseases associated with GPR142 include renal cell carcinoma, papillary. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR139.

UniProtKB/Swiss-Prot for GPR142 Gene

  • Orphan receptor

Gene Wiki entry for GPR142 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR142 Gene

Genomics for GPR142 Gene

Regulatory Elements for GPR142 Gene

Genomic Location for GPR142 Gene

Chromosome:
17
Start:
74,367,407 bp from pter
End:
74,373,008 bp from pter
Size:
5,602 bases
Orientation:
Plus strand

Genomic View for GPR142 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPR142 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR142 Gene

Proteins for GPR142 Gene

  • Protein details for GPR142 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z601-GP142_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 142
    Protein Accession:
    Q7Z601
    Secondary Accessions:
    • A4CYJ8
    • Q86SL3

    Protein attributes for GPR142 Gene

    Size:
    462 amino acids
    Molecular mass:
    51106 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR142 Gene

Proteomics data for GPR142 Gene at MOPED

Post-translational modifications for GPR142 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPR142 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GPR142 Gene

Domains & Families for GPR142 Gene

Gene Families for GPR142 Gene

Protein Domains for GPR142 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR142 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z601

UniProtKB/Swiss-Prot:

GP142_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR142: view

Function for GPR142 Gene

Molecular function for GPR142 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor

Gene Ontology (GO) - Molecular Function for GPR142 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0008528 G-protein coupled peptide receptor activity IBA --
genes like me logo Genes that share ontologies with GPR142: view

Phenotypes for GPR142 Gene

genes like me logo Genes that share phenotypes with GPR142: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPR142

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GPR142 Gene

Localization for GPR142 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR142 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR142 Gene COMPARTMENTS Subcellular localization image for GPR142 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR142 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
GO:0030054 cell junction IDA --
genes like me logo Genes that share ontologies with GPR142: view

Pathways & Interactions for GPR142 Gene

SuperPathways for GPR142 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • G Protein Coupled Receptors 384HT in human,mouse,rat

Interacting Proteins for GPR142 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000335158%0d%0a9606.ENSP00000263925%0d%0a9606.ENSP00000349238%0d%0a
Selected Interacting proteins: ENSP00000335158 for GPR142 Gene via STRING

Gene Ontology (GO) - Biological Process for GPR142 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with GPR142: view

No data available for Pathways by source and SIGNOR curated interactions for GPR142 Gene

Drugs & Compounds for GPR142 Gene

No Compound Related Data Available

Transcripts for GPR142 Gene

mRNA/cDNA for GPR142 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR142 Gene

G protein-coupled receptor 142:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPR142

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR142 Gene

No ASD Table

Relevant External Links for GPR142 Gene

GeneLoc Exon Structure for
GPR142
ECgene alternative splicing isoforms for
GPR142

Expression for GPR142 Gene

mRNA expression in normal human tissues for GPR142 Gene

mRNA differential expression in normal tissues according to GTEx for GPR142 Gene

This gene is overexpressed in Spleen (x6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR142 Gene



SOURCE GeneReport for Unigene cluster for GPR142 Gene Hs.574368

mRNA Expression by UniProt/SwissProt for GPR142 Gene

Q7Z601-GP142_HUMAN
Tissue specificity: Exclusively expressed in the central nervous system, most abundantly in the ventrolateral region of caudate putamen, the habenular nucleus, the zona incerta, and the medial mammillary nucleus.
genes like me logo Genes that share expression patterns with GPR142: view

Protein tissue co-expression partners for GPR142 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein differential expression in normal tissues for GPR142 Gene

Orthologs for GPR142 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR142 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPR142 35
  • 84.23 (n)
  • 79.32 (a)
GPR142 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPR142 35
  • 85.36 (n)
  • 81.21 (a)
GPR142 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr142 35
  • 79.2 (n)
  • 74.63 (a)
Gpr142 16
Gpr142 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPR142 35
  • 96.64 (n)
  • 95.52 (a)
GPR142 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr142 35
  • 81.38 (n)
  • 76.28 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia GPR142 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR142 35
  • 72.41 (n)
  • 64.19 (a)
GPR142 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR142 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr142 35
  • 60.72 (n)
  • 55.1 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100000501 35
  • 60.85 (n)
  • 58.36 (a)
gpr142 36
  • 45 (a)
OneToOne
Species with no ortholog for GPR142:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR142 Gene

ENSEMBL:
Gene Tree for GPR142 (if available)
TreeFam:
Gene Tree for GPR142 (if available)

Paralogs for GPR142 Gene

Paralogs for GPR142 Gene

(1) SIMAP similar genes for GPR142 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GPR142: view

Variants for GPR142 Gene

Sequence variations from dbSNP and Humsavar for GPR142 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2382646 -- 74,370,842(-) TACTT(G/T)TATTC intron-variant
rs2382647 - 74,370,556(-) GACGT(C/G/T)GGGCG missense, reference
rs3050698 -- 74,371,174(-) ATCTC(-/AAA/AAAAAA)AAAAA intron-variant
rs4789654 -- 74,366,913(+) AGGTG(C/T)ggccg upstream-variant-2KB
rs4789655 -- 74,367,014(+) TAACA(A/C/T)GGTGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GPR142 Gene

Variant ID Type Subtype PubMed ID
dgv12e196 CNV Duplication 17116639
dgv372n27 CNV Gain 19166990
nsv517569 CNV Gain+Loss 19592680
esv2751770 CNV Gain 17911159
nsv509673 CNV Insertion 20534489
nsv833538 CNV Gain 17160897
nsv833539 CNV Loss 17160897
esv33995 CNV Loss 17666407
nsv908741 CNV Loss 21882294
nsv908742 CNV Loss 21882294

Variation tolerance for GPR142 Gene

Residual Variation Intolerance Score: 95.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.90; 67.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR142 Gene

HapMap Linkage Disequilibrium report
GPR142

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR142 Gene

Disorders for GPR142 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPR142 Gene - From: DISEASES

Disorder Aliases PubMed IDs
renal cell carcinoma, papillary
  • renal cell carcinoma
- elite association

Relevant External Links for GPR142

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR142
genes like me logo Genes that share disorders with GPR142: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR142 Gene

Publications for GPR142 Gene

  1. Characterisation and differential expression of two very closely related G-protein-coupled receptors, GPR139 and GPR142, in mouse tissue and during mouse development. (PMID: 16378626) SA1sens U. … Schaller H.C. (Neuropharmacology 2006) 23 67
  2. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. (PMID: 14623098) Fredriksson R. … Schioeth H.B. (FEBS Lett. 2003) 2 67
  3. Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase. (PMID: 22889411) Guo Z. … Gao Y. (J. Proteome Res. 2012) 67
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 67
  5. Molecular cloning and characterization of a novel Gq-coupled orphan receptor GPRg1 exclusively expressed in the central nervous system. (PMID: 15845401) Matsuo A. … Shigeyoshi Y. (Biochem. Biophys. Res. Commun. 2005) 67

Products for GPR142 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • G Protein Coupled Receptors 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate GPR142
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for GPR142
    • Block miRNA regulation of GPR142 using miScript Target Protectors

    Sources for GPR142 Gene

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