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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GPR141 Gene

protein-coding   GIFtS: 43
GCID: GC07P037724

G Protein-Coupled Receptor 141

  Search for GPR141
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
G Protein-Coupled Receptor 1411 2
PGR132 3
G-Protein Coupled Receptor PGR132 3
Probable G-Protein Coupled Receptor 1412

External Ids:    HGNC: 199971   Entrez Gene: 3533452   Ensembl: ENSG000001870377   OMIM: 6090455   UniProtKB: Q7Z6023   

Export aliases for GPR141 gene to outside databases

Previous GC identifers: GC07U900327 GC07P037520 GC07P037553 GC07P037746 GC07P037659


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GPR141 Gene:
GPR141 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 (PubMed
14623098)).(supplied by OMIM, Mar 2008)

GeneCards Summary for GPR141 Gene: 
GPR141 (G protein-coupled receptor 141) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity.

UniProtKB/Swiss-Prot: GP141_HUMAN, Q7Z602
Function: Orphan receptor

Gene Wiki entry for GPR141 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007819.17  NC_018918.2  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GPR141 gene promoter:
         AML1a   CUTL1   NF-AT   HNF-1A   NF-AT4   NF-AT2   HNF-1   NF-AT3   Hlf   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPR141 promoter sequence
   Search SABiosciences Chromatin IP Primers for GPR141

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPR141


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14.1   Ensembl cytogenetic band:  7p14.1   HGNC cytogenetic band: 7p14.1

GPR141 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPR141 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P037724:  view genomic region     (about GC identifiers)

Start:
37,723,399 bp from pter      End:
37,873,390 bp from pter
Size:
149,992 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 37,817,623-37,818,540     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GP141_HUMAN, Q7Z602 (See protein sequence)
Recommended Name: Probable G-protein coupled receptor 141  
Size: 305 amino acids; 35464 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: A4D1X7 Q0VAR5 Q86SP3

Explore the universe of human proteins at neXtProt for GPR141: NX_Q7Z602

Explore proteomics data for GPR141 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7Z602

  • GPR141 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GPR141 Protein Expression
    REFSEQ proteins: NP_861456.1  
    ENSEMBL proteins: 
     ENSP00000396300   ENSP00000390410   ENSP00000334540  

    Human Recombinant Protein Products for GPR141: 
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane NAS--

    GPR141 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    GPCRAO: GPCR / Class A : Orphans

    IUPHAR Guide to PHARMACOLOGY protein family classification: GPR141 
    Class A Orphans

    2 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q7Z602

    ProtoNet protein and cluster: Q7Z602

    UniProtKB/Swiss-Prot: GP141_HUMAN, Q7Z602
    Similarity: Belongs to the G-protein coupled receptor 1 family


    GPR141 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GP141_HUMAN, Q7Z602
    Function: Orphan receptor

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity NAS--
         
    GPR141 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for GPR141:
     Increased S DNA content  Increased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GPR141 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GPR141

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway NAS--

    GPR141 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GPR141 (GP141)

    Search CenterWatch for drugs/clinical trials and news about GPR141 / GP141

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GPR141 gene: 
    NM_181791.1  

    Unigene Cluster for GPR141:

    G protein-coupled receptor 141
    Hs.688230  [show with all ESTs]
    Unigene Representative Sequence: AY288420
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000461610(uc003tfl.3) ENST00000450180 ENST00000467202 ENST00000447769
    ENST00000334425(uc003tfm.1)
    miRNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPR141
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPR141

    Additional mRNA sequence: 

    AY255538.1 AY288420.1 BC120951.2 BC120952.2 

    2 DOTS entries:

    DT.121039789  DT.91829995 

    21 AceView cDNA sequences:

    BG221739 AF202051 AF305596 AY255538 AY288420 NM_181791 BC043356 BP371009 
    BX952455 BM908078 BC036816 AL043096 AW590130 BF896644 AL598654 AI077399 
    AI375144 NM_016616 BU570921 CD699779 BX115172 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GPR141 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGAATACAA
    GPR141 Expression
    About this image


    See GPR141 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.688230
        SABiosciences Expression via Pathway-Focused PCR Array including GPR141: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR141

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for GPR141 gene from 4/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpr1411 , 5 G protein-coupled receptor 1411, 5 80.81(n)1
    81.25(a)1
      13 (7.04 cM)5
    3533461  NM_181754.41  NP_861419.31 
     197496825 
    chicken
    (Gallus gallus)
    Aves GPR1411 G protein-coupled receptor 141 61.5(n)
    57.56(a)
      420733  XM_418832.3  XP_418832.2 
    lizard
    (Anolis carolinensis)
    Reptilia GPR1416
    Uncharacterized protein
    63(a)
    1 ↔ 1
    6(47707631-47707915)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000035341 probable G-protein coupled receptor 141-like 54.1(n)
    43.08(a)
      100003534  XM_001343033.4  XP_001343069.2 


    ENSEMBL Gene Tree for GPR141 (if available)
    TreeFam Gene Tree for GPR141 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GPR141 gene
    7 SIMAP similar genes for GPR141 using alignment to 2 protein entries:     GP141_HUMAN (see all proteins):
    CCR7    SSTR5    CCR2    CCR5    OPRM1    LTB4R
    GPR18

    GPR141 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for GPR141
    PGOHUM00000233188


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/91 SNPs in GPR141 are shown (see all 91)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs171711551,2
    C,F--37778010(+) CATTCA/TTTCTT 1 -- us2k15Minor allele frequency- T:0.04NA CSA WA 262
    rs1827092101,2
    --37778060(+) ATAAAA/GCTACT 1 -- us2k10--------
    rs1880948361,2
    --37778130(+) AGTGTA/TACATG 1 -- us2k10--------
    rs132431991,2
    C,F,H--37778139(+) TGAGAC/TAGCTG 1 -- us2k118Minor allele frequency- T:0.12NS EA NA 2218
    rs1393613721,2
    C--37778233(+) GCTTTA/GTGAGG 1 -- us2k10--------
    rs1498947301,2
    C--37778242(+) GGTTGG/TGTTAT 1 -- us2k10--------
    rs117658111,2
    C,F,H--37778283(+) GGTATA/GAGTTA 1 -- us2k118Minor allele frequency- G:0.11NS EA NA WA 2338
    rs791637211,2
    C,F--37778363(+) CAACAT/CGATAT 1 -- us2k11Minor allele frequency- C:0.10WA 118
    rs1439482211,2
    --37778422(+) GATTTA/GCTTTT 1 -- us2k10--------
    rs1486512311,2
    --37778546(+) TCTAAA/TGAGTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GPR141 (37723399 - 37873390 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for GPR141:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv526136CNV Loss19592680
    nsv887959CNV Loss21882294
    dgv2075e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    GPR141 for disorders           About MalaCards
    OMIM gene information: 609045    OMIM disorders: --


    GPR141 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GPR141

    Export disorders for GPR141 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GPR141 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with GPR141)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. (PubMed id 14623098)1, 2, 3 Fredriksson R....Schioeth H.B. (2003)
    2. The G protein-coupled receptor repertoires of human and mouse. (PubMed id 12679517)1, 2, 3 Vassilatis D.K.... Gaitanaris G.A. (2003)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
    6. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)4 Yang Q....O'Donnell C.J. (2007)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 353345 HGNC: 19997 AceView: TXNDC3andGPR141 Ensembl:ENSG00000187037 euGenes: HUgn353345
    ECgene: GPR141 H-InvDB: GPR141

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GPR141 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GPR141 gene:
    Search GeneIP for patents involving GPR141

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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