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Aliases for GPR141 Gene

Aliases for GPR141 Gene

  • G Protein-Coupled Receptor 141 2 3 5
  • G-Protein Coupled Receptor PGR13 3 4
  • PGR13 3 4
  • Probable G-Protein Coupled Receptor 141 3

External Ids for GPR141 Gene

Previous GeneCards Identifiers for GPR141 Gene

  • GC07U900327
  • GC07P037520
  • GC07P037553
  • GC07P037746
  • GC07P037659

Summaries for GPR141 Gene

Entrez Gene Summary for GPR141 Gene

  • GPR141 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008]

GeneCards Summary for GPR141 Gene

GPR141 (G Protein-Coupled Receptor 141) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity.

UniProtKB/Swiss-Prot for GPR141 Gene

  • Orphan receptor.

Gene Wiki entry for GPR141 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR141 Gene

Genomics for GPR141 Gene

Regulatory Elements for GPR141 Gene

Enhancers for GPR141 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F037733 0.5 FANTOM5 15.2 +49.7 49655 0.2 GPR141 EPDR1 ELMO1 LOC100420413
GH07F037736 1.2 FANTOM5 14.7 +52.7 52737 0.1 ZNF585B GPR141 ELMO1 EPDR1 NME8 LOC100420413
GH07F037704 0.8 FANTOM5 14.3 +20.9 20882 0.4 GLIS1 GPR141 ELMO1 EPDR1 STARD3NL LOC100420413
GH07F037443 1 FANTOM5 ENCODE 13.7 -236.7 -236668 6.1 HDGF ELF3 SIN3A FEZF1 ZNF48 ZNF2 RAD21 GLIS2 EGR1 CBX5 GPR141 RNU6-565P EPDR1 ELMO1 TRGV3 ENSG00000201566
GH07F037765 1.6 FANTOM5 Ensembl ENCODE 13.5 +82.4 82440 1.7 TBL1XR1 ASH2L RELA CBX5 EED NFE2 CREM MTA2 CBFB BHLHE40 GPR141 EPDR1 STARD3NL ELMO1 LOC100420413
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GPR141 on UCSC Golden Path with GeneCards custom track

Promoters for GPR141 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for GPR141 Gene

37,683,625 bp from pter
37,833,788 bp from pter
150,164 bases
Plus strand

Genomic View for GPR141 Gene

Genes around GPR141 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR141 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR141 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR141 Gene

Proteins for GPR141 Gene

  • Protein details for GPR141 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 141
    Protein Accession:
    Secondary Accessions:
    • A4D1X7
    • Q0VAR5
    • Q86SP3

    Protein attributes for GPR141 Gene

    305 amino acids
    Molecular mass:
    35464 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR141 Gene

Post-translational modifications for GPR141 Gene

  • Glycosylation at Asn 5 and Asn 9
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPR141 Gene

Domains & Families for GPR141 Gene

Gene Families for GPR141 Gene

Protein Domains for GPR141 Gene

Suggested Antigen Peptide Sequences for GPR141 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR141: view

Function for GPR141 Gene

Molecular function for GPR141 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Gene Ontology (GO) - Molecular Function for GPR141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GPR141: view
genes like me logo Genes that share phenotypes with GPR141: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR141

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR141 Gene

Localization for GPR141 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR141 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GPR141 Gene COMPARTMENTS Subcellular localization image for GPR141 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for GPR141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR141: view

Pathways & Interactions for GPR141 Gene

SuperPathways for GPR141 Gene

No Data Available

Interacting Proteins for GPR141 Gene

Gene Ontology (GO) - Biological Process for GPR141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR141: view

No data available for Pathways by source and SIGNOR curated interactions for GPR141 Gene

Transcripts for GPR141 Gene

Unigene Clusters for GPR141 Gene

G protein-coupled receptor 141:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR141 Gene

No ASD Table

Relevant External Links for GPR141 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR141 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR141 Gene

mRNA differential expression in normal tissues according to GTEx for GPR141 Gene

This gene is overexpressed in Whole Blood (x36.9).

NURSA nuclear receptor signaling pathways regulating expression of GPR141 Gene:


SOURCE GeneReport for Unigene cluster for GPR141 Gene:

genes like me logo Genes that share expression patterns with GPR141: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for GPR141 Gene

Orthologs for GPR141 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR141 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR141 34 35
  • 99.67 (n)
(Canis familiaris)
Mammalia GPR141 34 35
  • 85.94 (n)
(Bos Taurus)
Mammalia LOC538837 34
  • 83.28 (n)
GPR141 35
  • 81 (a)
(Mus musculus)
Mammalia Gpr141 34 16 35
  • 80.81 (n)
(Monodelphis domestica)
Mammalia GPR141 35
  • 58 (a)
(Gallus gallus)
Aves GPR141 34 35
  • 60.8 (n)
(Anolis carolinensis)
Reptilia GPR141 35
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr141 34
  • 59.31 (n)
(Danio rerio)
Actinopterygii LOC100003534 34
  • 53.88 (n)
GPR141 35
  • 37 (a)
Species where no ortholog for GPR141 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR141 Gene

Gene Tree for GPR141 (if available)
Gene Tree for GPR141 (if available)

Paralogs for GPR141 Gene

(7) SIMAP similar genes for GPR141 Gene using alignment to 2 proteins: Pseudogenes for GPR141 Gene

genes like me logo Genes that share paralogs with GPR141: view

No data available for Paralogs for GPR141 Gene

Variants for GPR141 Gene

Sequence variations from dbSNP and Humsavar for GPR141 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1006050 -- 37,694,261(-) ccact(C/T)gctgc intron-variant
rs1013906 -- 37,687,443(+) AAATA(A/G)AAATA intron-variant
rs10227093 -- 37,731,433(+) AAAAA(C/T)TCCCA intron-variant
rs10232856 -- 37,699,748(+) CTTTG(A/C)ATAAG intron-variant
rs10233369 -- 37,730,255(+) CACAT(A/G)CCATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR141 Gene

Variant ID Type Subtype PubMed ID
dgv1281e214 CNV loss 21293372
esv2759523 CNV loss 17122850
nsv526136 CNV loss 19592680

Variation tolerance for GPR141 Gene

Residual Variation Intolerance Score: 31.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR141 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR141 Gene

Disorders for GPR141 Gene

Relevant External Links for GPR141

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GPR141 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR141 Gene

Publications for GPR141 Gene

  1. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis D.K. … Gaitanaris G.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4 64
  2. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. (PMID: 14623098) Fredriksson R. … Schioeth H.B. (FEBS Lett. 2003) 2 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  5. Neomorphic effects of recurrent somatic mutations in Yin Yang 1 in insulin-producing adenomas. (PMID: 25787250) Cromer M.K. … Lifton R.P. (Proc. Natl. Acad. Sci. U.S.A. 2015) 4 64

Products for GPR141 Gene

Sources for GPR141 Gene

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