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GPR141 Gene

protein-coding   GIFtS: 42
GCID: GC07P037724

G Protein-Coupled Receptor 141

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
G Protein-Coupled Receptor 1411 2
PGR132 3 5
G-Protein Coupled Receptor PGR132 3
Probable G-Protein Coupled Receptor 1412

External Ids:    HGNC: 199971   Entrez Gene: 3533452   Ensembl: ENSG000001870377   OMIM: 6090455   UniProtKB: Q7Z6023   

Export aliases for GPR141 gene to outside databases

Previous GC identifers: GC07U900327 GC07P037520 GC07P037553 GC07P037746 GC07P037659


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GPR141 Gene:
GPR141 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 (PubMed
14623098)).(supplied by OMIM, Mar 2008)

GeneCards Summary for GPR141 Gene:
GPR141 (G protein-coupled receptor 141) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity.

UniProtKB/Swiss-Prot: GP141_HUMAN, Q7Z602
Function: Orphan receptor

Gene Wiki entry for GPR141 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the GPR141 gene promoter:
         AML1a   CUTL1   NF-AT   HNF-1A   NF-AT4   NF-AT2   HNF-1   NF-AT3   Hlf   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPR141 promoter sequence
   Search Chromatin IP Primers for GPR141

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GPR141


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14.1   Ensembl cytogenetic band:  7p14.1   HGNC cytogenetic band: 7p14.1

GPR141 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPR141 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P037724:  view genomic region     (about GC identifiers)

Start:
37,723,399 bp from pter      End:
37,873,390 bp from pter
Size:
149,992 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 37,817,623-37,818,540     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GP141_HUMAN, Q7Z602 (See protein sequence)
Recommended Name: Probable G-protein coupled receptor 141  
Size: 305 amino acids; 35464 Da
Secondary accessions: A4D1X7 Q0VAR5 Q86SP3

Explore the universe of human proteins at neXtProt for GPR141: NX_Q7Z602

Explore proteomics data for GPR141 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5, Asn9
  • Modification sites at PhosphoSitePlus

  • See GPR141 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_861456.1  
    ENSEMBL proteins: 
     ENSP00000396300   ENSP00000390410   ENSP00000334540  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GPCRAO: GPCR / Class A : Orphans

    IUPHAR Guide to PHARMACOLOGY protein family classification: GPR141
    Class A Orphans

    2 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q7Z602

    ProtoNet protein and cluster: Q7Z602

    UniProtKB/Swiss-Prot: GP141_HUMAN, Q7Z602
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with GPR141           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GP141_HUMAN, Q7Z602
    Function: Orphan receptor

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
         
    Find genes that share ontologies with GPR141           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for GPR141:
     Increased S DNA content  Increased homologous recombina 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for GPR141

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GP141_HUMAN, Q7Z602: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    golgi apparatus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with GPR141           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including GPR141: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for GPR141

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with GPR141           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for GPR141 (GP141)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GPR141 gene: 
    NM_181791.1  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000461610(uc003tfl.3) ENST00000450180 ENST00000467202 ENST00000447769
    ENST00000334425(uc003tfm.1)
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    21 AceView cDNA sequences:

    BG221739 AY255538 AF305596 NM_181791 AY288420 AF202051 BP371009 BC043356 
    BC036816 NM_016616 BM908078 AI077399 BX952455 AI375144 AW590130 BF896644 
    AL043096 AL598654 BU570921 CD699779 BX115172 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GPR141 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGAATACAA
    GPR141 Expression
    About this image

    GPR141 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GPR141 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Array including GPR141: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for GPR141 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpr1411 , 5 G protein-coupled receptor 1411, 5 80.81(n)1
    81.25(a)1
      13 (7.04 cM)5
    3533461  NM_181754.41  NP_861419.31 
     197496825 
    chicken
    (Gallus gallus)
    Aves GPR1411 G protein-coupled receptor 141 60.8(n)
    55.17(a)
      420733  XM_004939529.1  XP_004939586.1 
    lizard
    (Anolis carolinensis)
    Reptilia GPR1416
    G protein-coupled receptor 141
    63(a)
    1 ↔ 1
    6(47707631-47707915)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia gpr1411 G protein-coupled receptor 141 59.31(n)
    50.9(a)
      100492560  XM_002939420.2  XP_002939466.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000035341 probable G-protein coupled receptor 141-like 53.88(n)
    43.23(a)
      100003534  XM_001343033.5  XP_001343069.2 


    ENSEMBL Gene Tree for GPR141 (if available)
    TreeFam Gene Tree for GPR141 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GPR141 gene
    7 SIMAP similar genes for GPR141 using alignment to 2 protein entries:     GP141_HUMAN (see all proteins):
    CCR7    SSTR5    CCR2    CCR5    OPRM1    LTB4R
    GPR18

    Find genes that share paralogs with GPR141           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for GPR141
    PGOHUM00000233188


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GPR141 (see all 91)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs171711551,2
    C,F--37778010(+) CATTCA/TTTCTT 1 -- us2k15Minor allele frequency- T:0.04NA CSA WA 262
    rs1827092101,2
    --37778060(+) ATAAAA/GCTACT 1 -- us2k10--------
    rs1880948361,2
    --37778130(+) AGTGTA/TACATG 1 -- us2k10--------
    rs132431991,2
    C,F,H--37778139(+) TGAGAC/TAGCTG 1 -- us2k118Minor allele frequency- T:0.12NS EA NA 2218
    rs1393613721,2
    C--37778233(+) GCTTTA/GTGAGG 1 -- us2k10--------
    rs1498947301,2
    C--37778242(+) GGTTGG/TGTTAT 1 -- us2k10--------
    rs117658111,2
    C,F,H--37778283(+) GGTATA/GAGTTA 1 -- us2k118Minor allele frequency- G:0.11NS EA NA WA 2338
    rs791637211,2
    C,F--37778363(+) CAACAT/CGATAT 1 -- us2k11Minor allele frequency- C:0.10WA 118
    rs1439482211,2
    --37778422(+) GATTTA/GCTTTT 1 -- us2k10--------
    rs1486512311,2
    --37778546(+) TCTAAA/TGAGTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GPR141 (37723399 - 37873390 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for GPR141:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv526136CNV Loss19592680
    nsv887959CNV Loss21882294
    dgv2075e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609045    OMIM disorders: --


    Find genes that share disorders with GPR141           About GenesLikeMe

    Genetic Association Database (GAD): GPR141

    Export disorders for GPR141 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GPR141 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with GPR141)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. (PubMed id 14623098)1, 2, 3 Fredriksson R....Schioeth H.B. (FEBS Lett. 2003)
    2. The G protein-coupled receptor repertoires of human and mouse. (PubMed id 12679517)1, 2, 3 Vassilatis D.K.... Gaitanaris G.A. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    6. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)4 Yang Q....O'Donnell C.J. (BMC Med. Genet. 2007)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 353345 HGNC: 19997 AceView: TXNDC3andGPR141 Ensembl:ENSG00000187037 euGenes: HUgn353345
    ECgene: GPR141 H-InvDB: GPR141

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GPR141 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GPR141 gene:
    Search GeneIP for patents involving GPR141

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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