Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GPR141 Gene

Aliases for GPR141 Gene

  • G Protein-Coupled Receptor 141 2 3 5
  • G-Protein Coupled Receptor PGR13 3 4
  • PGR13 3 4
  • Probable G-Protein Coupled Receptor 141 3

External Ids for GPR141 Gene

Previous GeneCards Identifiers for GPR141 Gene

  • GC07U900327
  • GC07P037520
  • GC07P037553
  • GC07P037746
  • GC07P037659

Summaries for GPR141 Gene

Entrez Gene Summary for GPR141 Gene

  • GPR141 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008]

GeneCards Summary for GPR141 Gene

GPR141 (G Protein-Coupled Receptor 141) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity.

UniProtKB/Swiss-Prot for GPR141 Gene

  • Orphan receptor.

Gene Wiki entry for GPR141 Gene

Additional gene information for GPR141 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR141 Gene

Genomics for GPR141 Gene

Regulatory Elements for GPR141 Gene

Enhancers for GPR141 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H037443 1.8 FANTOM5 Ensembl ENCODE dbSUPER 13.7 -236.7 -236722 6 HDGF SIN3A FEZF1 ZNF2 ETS1 GLIS2 ATF7 RUNX3 REST GLIS1 GPR141 RNU6-565P EPDR1 ELMO1 TRGV3 ENSG00000201566
GH07H037765 1.4 FANTOM5 Ensembl ENCODE 13.6 +82.4 82449 1 TBL1XR1 BATF RELA POLR2A EED ATF7 NFE2 RUNX3 IKZF2 CREM GPR141 EPDR1 STARD3NL ELMO1 LOC100420413
GH07H037732 1.3 Ensembl ENCODE dbSUPER 11.2 +48.8 48776 0 GTF2F1 CTCF JUN MAX CEBPG ZBTB40 RAD21 RFX5 GATA3 SMC3 GPR141 EPDR1 NME8 LOC100420413
GH07H037728 1.2 Ensembl ENCODE dbSUPER 11.1 +45.5 45507 1 JUN BATF EED ATF7 IKZF2 CREM ZNF687 JUNB CEBPB DPF2 EPDR1 GPR141 NME8 LOC100420413
GH07H037408 1.2 Ensembl ENCODE dbSUPER 9.4 -273.8 -273787 3 FOXA2 MAX REST RAD21 FOXA1 GABPA YY1 JUND ATF3 FOS ELMO1 RNU6-565P EPDR1 GPR141 GC07P037419 RPS10P14
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPR141 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR141 Gene

Chromosome:
7
Start:
37,683,625 bp from pter
End:
37,833,788 bp from pter
Size:
150,164 bases
Orientation:
Plus strand

Genomic View for GPR141 Gene

Genes around GPR141 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR141 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR141 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR141 Gene

Proteins for GPR141 Gene

  • Protein details for GPR141 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z602-GP141_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 141
    Protein Accession:
    Q7Z602
    Secondary Accessions:
    • A4D1X7
    • Q0VAR5
    • Q86SP3

    Protein attributes for GPR141 Gene

    Size:
    305 amino acids
    Molecular mass:
    35464 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR141 Gene

Post-translational modifications for GPR141 Gene

  • Glycosylation at isoforms=5 and posLast=99
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPR141 Gene

Domains & Families for GPR141 Gene

Gene Families for GPR141 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR141 Gene

Suggested Antigen Peptide Sequences for GPR141 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z602

UniProtKB/Swiss-Prot:

GP141_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR141: view

Function for GPR141 Gene

Molecular function for GPR141 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Phenotypes From GWAS Catalog for GPR141 Gene

Gene Ontology (GO) - Molecular Function for GPR141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GPR141: view
genes like me logo Genes that share phenotypes with GPR141: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR141

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GPR141
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR141 Gene

Localization for GPR141 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR141 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR141 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for GPR141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR141: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR141 Gene

Pathways & Interactions for GPR141 Gene

SuperPathways for GPR141 Gene

No Data Available

Interacting Proteins for GPR141 Gene

Gene Ontology (GO) - Biological Process for GPR141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR141: view

No data available for Pathways by source and SIGNOR curated interactions for GPR141 Gene

Drugs & Compounds for GPR141 Gene

No Compound Related Data Available

Transcripts for GPR141 Gene

Unigene Clusters for GPR141 Gene

G protein-coupled receptor 141:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GPR141
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for GPR141 Gene

No ASD Table

Relevant External Links for GPR141 Gene

GeneLoc Exon Structure for
GPR141
ECgene alternative splicing isoforms for
GPR141

Expression for GPR141 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR141 Gene

mRNA differential expression in normal tissues according to GTEx for GPR141 Gene

This gene is overexpressed in Whole Blood (x36.9).

NURSA nuclear receptor signaling pathways regulating expression of GPR141 Gene:

GPR141

SOURCE GeneReport for Unigene cluster for GPR141 Gene:

Hs.688230
genes like me logo Genes that share expression patterns with GPR141: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR141 Gene

Orthologs for GPR141 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR141 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR141 33 34
  • 99.67 (n)
dog
(Canis familiaris)
Mammalia GPR141 33 34
  • 85.94 (n)
cow
(Bos Taurus)
Mammalia LOC538837 33
  • 83.28 (n)
GPR141 34
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr141 33 16 34
  • 80.81 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR141 34
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR141 33 34
  • 60.8 (n)
lizard
(Anolis carolinensis)
Reptilia GPR141 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr141 33
  • 59.31 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100003534 33
  • 53.88 (n)
GPR141 34
  • 37 (a)
OneToMany
Species where no ortholog for GPR141 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR141 Gene

ENSEMBL:
Gene Tree for GPR141 (if available)
TreeFam:
Gene Tree for GPR141 (if available)

Paralogs for GPR141 Gene

(7) SIMAP similar genes for GPR141 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for GPR141 Gene

genes like me logo Genes that share paralogs with GPR141: view

No data available for Paralogs for GPR141 Gene

Variants for GPR141 Gene

Sequence variations from dbSNP and Humsavar for GPR141 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000012242 -- 37,732,472(+) GATGC(A/G)GATCA intron-variant
rs1000058595 -- 37,685,859(+) TCTAA(A/G)AGTGC intron-variant
rs1000074545 -- 37,714,067(+) CTTAC(A/C)CATAT intron-variant, upstream-variant-2KB
rs1000084504 -- 37,725,659(+) TTTCA(A/G)AGGAC intron-variant, utr-variant-5-prime
rs1000150760 -- 37,727,512(+) TTCCA(C/T)TTTGC intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for GPR141 Gene

Variant ID Type Subtype PubMed ID
dgv1281e214 CNV loss 21293372
esv2759523 CNV loss 17122850
nsv526136 CNV loss 19592680

Variation tolerance for GPR141 Gene

Residual Variation Intolerance Score: 31.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR141 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR141

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR141 Gene

Disorders for GPR141 Gene

Relevant External Links for GPR141

Genetic Association Database (GAD)
GPR141
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR141

No disorders were found for GPR141 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR141 Gene

Publications for GPR141 Gene

  1. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. (PMID: 14623098) Fredriksson R … Schiöth HB (FEBS letters 2003) 2 3 4 60
  2. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis DK … Gaitanaris GA (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for GPR141 Gene

Sources for GPR141 Gene

Content
Loading form....