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Aliases for GPR137B Gene

Aliases for GPR137B Gene

  • G Protein-Coupled Receptor 137B 2 3 5
  • Transmembrane 7 Superfamily Member 1 (Upregulated In Kidney) 2 3
  • Transmembrane 7 Superfamily Member 1 Protein 3 4
  • TM7SF1 3 4
  • Integral Membrane Protein GPR137B 3

External Ids for GPR137B Gene

Previous HGNC Symbols for GPR137B Gene

  • TM7SF1

Previous GeneCards Identifiers for GPR137B Gene

  • GC01P232632
  • GC01P234372
  • GC01P236305
  • GC01P206762

Summaries for GPR137B Gene

GeneCards Summary for GPR137B Gene

GPR137B (G Protein-Coupled Receptor 137B) is a Protein Coding gene. An important paralog of this gene is GPR137.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR137B Gene

Genomics for GPR137B Gene

Regulatory Elements for GPR137B Gene

Enhancers for GPR137B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F236156 1.4 FANTOM5 Ensembl ENCODE 20.8 +14.2 14173 1.3 HDGF TBP PKNOX1 TBL1XR1 WRNIP1 BMI1 ETV6 RCOR1 CREM SMAD5 GPR137B LGALS8 LYST GC01P236268
GH01F236162 0.2 ENCODE 19.1 +21.1 21068 1.2 HDGF PKNOX1 ZNF493 ZNF76 YBX1 BMI1 ZNF23 EGR2 ZNF202 ZNF680 ENSG00000273058 HEATR1 ENSG00000230325 RPS21P1 MTR GPR137B LOC100130485 RPSAP21 RPL35P1 GC01P236268
GH01F236151 0.2 ENCODE 17.8 +7.7 7674 0.2 HDGF YBX1 GLI4 ZNF514 ZKSCAN1 ZNF155 ZBTB48 ZNF207 SCRT1 NR4A1 ENSG00000273058 ENSG00000230325 RPS21P1 GPR137B MTR TBCE HEATR1 GC01P236268
GH01F236168 1 Ensembl ENCODE 16.2 +26.6 26622 0.6 ELF3 HDAC1 ATF1 RAD21 ZEB1 YY1 RARA ELK1 FOS CREM GPR137B GC01P236268
GH01F236159 1.6 FANTOM5 Ensembl ENCODE 14.8 +17.6 17619 2.0 HDGF PKNOX1 CBX3 TBL1XR1 WRNIP1 ZBTB40 ZNF121 EGR1 ETV6 CREM GPR137B RPS21P1 ENSG00000230325 ENSG00000273058 HEATR1 MTR RPL35P1 LGALS8 LYST GC01P236268
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GPR137B on UCSC Golden Path with GeneCards custom track

Promoters for GPR137B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000555568 298 3201 PKNOX1 SIN3A FEZF1 ZNF2 ZNF121 GLIS2 ZNF302 ZNF143 ZNF207 ZNF548

Genomic Location for GPR137B Gene

Chromosome:
1
Start:
236,142,502 bp from pter
End:
236,221,865 bp from pter
Size:
79,364 bases
Orientation:
Plus strand

Genomic View for GPR137B Gene

Genes around GPR137B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR137B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR137B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR137B Gene

Proteins for GPR137B Gene

  • Protein details for GPR137B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60478-G137B_HUMAN
    Recommended name:
    Integral membrane protein GPR137B
    Protein Accession:
    O60478
    Secondary Accessions:
    • Q53EK7
    • Q5TAE6
    • Q6FHI3

    Protein attributes for GPR137B Gene

    Size:
    399 amino acids
    Molecular mass:
    45599 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR137B Gene

Post-translational modifications for GPR137B Gene

  • Glycosylation at Asn 26, Asn 263, and Asn 275
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR137B Gene

No data available for DME Specific Peptides for GPR137B Gene

Domains & Families for GPR137B Gene

Protein Domains for GPR137B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O60478

UniProtKB/Swiss-Prot:

G137B_HUMAN :
  • Belongs to the GPR137 family.
Family:
  • Belongs to the GPR137 family.
genes like me logo Genes that share domains with GPR137B: view

No data available for Gene Families for GPR137B Gene

Function for GPR137B Gene

Phenotypes for GPR137B Gene

genes like me logo Genes that share phenotypes with GPR137B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR137B

miRNA for GPR137B Gene

miRTarBase miRNAs that target GPR137B

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR137B Gene

Localization for GPR137B Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR137B Gene

Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR137B Gene COMPARTMENTS Subcellular localization image for GPR137B gene
Compartment Confidence
plasma membrane 5
lysosome 3
vacuole 3

Gene Ontology (GO) - Cellular Components for GPR137B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IEA --
GO:0005887 integral component of plasma membrane TAS 9521871
GO:0016020 membrane IEA,TAS 9521871
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR137B: view

Pathways & Interactions for GPR137B Gene

SuperPathways for GPR137B Gene

No Data Available

Interacting Proteins for GPR137B Gene

Gene Ontology (GO) - Biological Process for GPR137B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GPR137B Gene

Transcripts for GPR137B Gene

Unigene Clusters for GPR137B Gene

G protein-coupled receptor 137B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR137B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d
SP1: - - - -
SP2: - - -
SP3: -
SP4:
SP5: -
SP6:

Relevant External Links for GPR137B Gene

GeneLoc Exon Structure for
GPR137B
ECgene alternative splicing isoforms for
GPR137B

Expression for GPR137B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR137B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GPR137B Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR137B Gene



Protein tissue co-expression partners for GPR137B Gene

NURSA nuclear receptor signaling pathways regulating expression of GPR137B Gene:

GPR137B

SOURCE GeneReport for Unigene cluster for GPR137B Gene:

Hs.498160

mRNA Expression by UniProt/SwissProt for GPR137B Gene:

O60478-G137B_HUMAN
Tissue specificity: Expressed in kidney, heart, brain and placenta.
genes like me logo Genes that share expression patterns with GPR137B: view

Primer Products

No data available for mRNA differential expression in normal tissues for GPR137B Gene

Orthologs for GPR137B Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR137B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR137B 34 35
  • 100 (n)
cow
(Bos Taurus)
Mammalia GPR137B 34 35
  • 92.36 (n)
dog
(Canis familiaris)
Mammalia GPR137B 34 35
  • 91.92 (n)
mouse
(Mus musculus)
Mammalia Gpr137b 34 16 35
  • 90.28 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR137B 35
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR137B 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR137B 34 35
  • 78.51 (n)
lizard
(Anolis carolinensis)
Reptilia GPR137B 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr137b 34
  • 72.83 (n)
Str.3726 34
zebrafish
(Danio rerio)
Actinopterygii GPR137B (2 of 2) 35
  • 71 (a)
OneToMany
LOC100001171 34
  • 70.2 (n)
GPR137B (1 of 2) 35
  • 60 (a)
OneToMany
wufi39g02 34
Species where no ortholog for GPR137B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR137B Gene

ENSEMBL:
Gene Tree for GPR137B (if available)
TreeFam:
Gene Tree for GPR137B (if available)

Paralogs for GPR137B Gene

Paralogs for GPR137B Gene

(4) SIMAP similar genes for GPR137B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GPR137B: view

Variants for GPR137B Gene

Sequence variations from dbSNP and Humsavar for GPR137B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10159006 -- 236,185,560(+) CCTTA(C/T)CCTTT intron-variant
rs10465608 -- 236,161,093(+) CACGC(C/T)CTCCA intron-variant
rs10495374 -- 236,181,768(+) AAGGG(C/T)GTGCA intron-variant
rs10581092 -- 236,164,887(+) ATTCA(-/AG)AGAGA intron-variant
rs10671487 -- 236,210,163(+) TTTGT(-/TAGA)TAGAT nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GPR137B Gene

Variant ID Type Subtype PubMed ID
dgv156e212 CNV loss 25503493
dgv590n100 CNV gain 25217958
esv1123909 CNV insertion 17803354
esv28317 CNV loss 19812545
esv3345110 CNV duplication 20981092
esv3578490 CNV loss 25503493
esv3589211 CNV loss 21293372
nsv1005877 CNV gain 25217958
nsv1012436 CNV loss 25217958
nsv468428 CNV loss 19166990
nsv468439 CNV loss 19166990
nsv549394 CNV gain 21841781
nsv549397 CNV loss 21841781
nsv549398 CNV loss 21841781
nsv549399 CNV gain 21841781
nsv827476 CNV gain 20364138
nsv832969 CNV gain 17160897
nsv953998 CNV deletion 24416366

Variation tolerance for GPR137B Gene

Residual Variation Intolerance Score: 48.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR137B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR137B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR137B Gene

Disorders for GPR137B Gene

Relevant External Links for GPR137B

Genetic Association Database (GAD)
GPR137B
Human Genome Epidemiology (HuGE) Navigator
GPR137B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR137B

No disorders were found for GPR137B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR137B Gene

Publications for GPR137B Gene

  1. Cloning and characterization of a novel gene (TM7SF1) encoding a putative seven-pass transmembrane protein that is upregulated during kidney development. (PMID: 9521871) Spangenberg C. … Lobbert R.W. (Genomics 1998) 2 3 4 64
  2. Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. (PMID: 21107309) McClay J.L. … van den Oord E.J. (Neuropsychopharmacology 2011) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. TM7SF1 (GPR137B): a novel lysosome integral membrane protein. (PMID: 22729905) Gao J. … Wang L. (Mol. Biol. Rep. 2012) 4 64

Products for GPR137B Gene

Sources for GPR137B Gene

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