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Aliases for GPR137B Gene

Aliases for GPR137B Gene

  • G Protein-Coupled Receptor 137B 2 3 5
  • Transmembrane 7 Superfamily Member 1 (Upregulated In Kidney) 2 3
  • Transmembrane 7 Superfamily Member 1 Protein 3 4
  • TM7SF1 3 4

External Ids for GPR137B Gene

Previous HGNC Symbols for GPR137B Gene

  • TM7SF1

Previous GeneCards Identifiers for GPR137B Gene

  • GC01P232632
  • GC01P234372
  • GC01P236305
  • GC01P206762

Summaries for GPR137B Gene

GeneCards Summary for GPR137B Gene

GPR137B (G Protein-Coupled Receptor 137B) is a Protein Coding gene. An important paralog of this gene is GPR137.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR137B Gene

Genomics for GPR137B Gene

Regulatory Elements for GPR137B Gene

Enhancers for GPR137B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPR137B on UCSC Golden Path with GeneCards custom track

Promoters for GPR137B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPR137B on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR137B Gene

236,142,502 bp from pter
236,221,865 bp from pter
79,364 bases
Plus strand

Genomic View for GPR137B Gene

Genes around GPR137B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR137B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR137B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR137B Gene

Proteins for GPR137B Gene

  • Protein details for GPR137B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Integral membrane protein GPR137B
    Protein Accession:
    Secondary Accessions:
    • Q53EK7
    • Q5TAE6
    • Q6FHI3

    Protein attributes for GPR137B Gene

    399 amino acids
    Molecular mass:
    45599 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR137B Gene

Proteomics data for GPR137B Gene at MOPED

Post-translational modifications for GPR137B Gene

  • Glycosylation at Asn 26, Asn 263, and Asn 275
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR137B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR137B Gene

Domains & Families for GPR137B Gene

Protein Domains for GPR137B Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GPR137 family.
  • Belongs to the GPR137 family.
genes like me logo Genes that share domains with GPR137B: view

No data available for Gene Families for GPR137B Gene

Function for GPR137B Gene

Phenotypes for GPR137B Gene

genes like me logo Genes that share phenotypes with GPR137B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR137B

CRISPR Products

miRNA for GPR137B Gene

miRTarBase miRNAs that target GPR137B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR137B Gene

Localization for GPR137B Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR137B Gene

Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GPR137B Gene COMPARTMENTS Subcellular localization image for GPR137B gene
Compartment Confidence
plasma membrane 5
lysosome 3
vacuole 3

Gene Ontology (GO) - Cellular Components for GPR137B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IEA --
GO:0016020 membrane TAS 9521871
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR137B: view

Pathways & Interactions for GPR137B Gene

SuperPathways for GPR137B Gene

No Data Available

Interacting Proteins for GPR137B Gene

Gene Ontology (GO) - Biological Process for GPR137B Gene


No data available for Pathways by source and SIGNOR curated interactions for GPR137B Gene

Drugs & Compounds for GPR137B Gene

No Compound Related Data Available

Transcripts for GPR137B Gene

Unigene Clusters for GPR137B Gene

G protein-coupled receptor 137B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR137B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d
SP1: - - - -
SP2: - - -
SP3: -
SP5: -

Relevant External Links for GPR137B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR137B Gene

mRNA expression in normal human tissues for GPR137B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GPR137B Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR137B Gene

SOURCE GeneReport for Unigene cluster for GPR137B Gene Hs.498160

mRNA Expression by UniProt/SwissProt for GPR137B Gene

Tissue specificity: Expressed in kidney, heart, brain and placenta.
genes like me logo Genes that share expression patterns with GPR137B: view

Protein tissue co-expression partners for GPR137B Gene

Primer Products

No data available for mRNA differential expression in normal tissues for GPR137B Gene

Orthologs for GPR137B Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR137B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPR137B 35
  • 92.36 (n)
  • 95.31 (a)
GPR137B 36
  • 93 (a)
(Canis familiaris)
Mammalia GPR137B 35
  • 91.92 (n)
  • 94.19 (a)
GPR137B 36
  • 93 (a)
(Mus musculus)
Mammalia Gpr137b 35
  • 90.28 (n)
  • 95.05 (a)
Gpr137b 16
Gpr137b 36
  • 95 (a)
(Pan troglodytes)
Mammalia GPR137B 35
  • 100 (n)
  • 100 (a)
GPR137B 36
  • 100 (a)
(Monodelphis domestica)
Mammalia GPR137B 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia GPR137B 36
  • 79 (a)
(Gallus gallus)
Aves GPR137B 35
  • 78.51 (n)
  • 88.86 (a)
GPR137B 36
  • 88 (a)
(Anolis carolinensis)
Reptilia GPR137B 36
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr137b 35
  • 72.83 (n)
  • 80.97 (a)
Str.3726 35
(Danio rerio)
Actinopterygii LOC100001171 35
  • 70.2 (n)
  • 73.1 (a)
wufi39g02 35
GPR137B (1 of 2) 36
  • 60 (a)
GPR137B (2 of 2) 36
  • 71 (a)
Species with no ortholog for GPR137B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR137B Gene

Gene Tree for GPR137B (if available)
Gene Tree for GPR137B (if available)

Paralogs for GPR137B Gene

Paralogs for GPR137B Gene

(4) SIMAP similar genes for GPR137B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GPR137B: view

Variants for GPR137B Gene

Sequence variations from dbSNP and Humsavar for GPR137B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs5873 -- 236,208,531(-) TCTAT(A/G)TTTTT downstream-variant-500B, utr-variant-3-prime
rs911270 -- 236,140,947(+) CTCTA(A/T)CCCCA upstream-variant-2KB
rs911271 -- 236,146,724(+) AACTT(A/C)CCCCT intron-variant
rs1254195 -- 236,198,289(-) aggca(C/G)agatt intron-variant
rs1254196 -- 236,198,269(-) caata(C/T)cacac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR137B Gene

Variant ID Type Subtype PubMed ID
nsv873326 CNV Gain 21882294
nsv832969 CNV Gain 17160897
nsv468428 CNV Loss 19166990
nsv468439 CNV Loss 19166990
nsv827476 CNV Gain 20364138
dgv550n71 CNV Gain 21882294
esv1123909 CNV Insertion 17803354
esv28317 CNV Loss 19812545

Variation tolerance for GPR137B Gene

Residual Variation Intolerance Score: 48.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.32% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GPR137B Gene

Disorders for GPR137B Gene

Relevant External Links for GPR137B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GPR137B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR137B Gene

Publications for GPR137B Gene

  1. Cloning and characterization of a novel gene (TM7SF1) encoding a putative seven-pass transmembrane protein that is upregulated during kidney development. (PMID: 9521871) Spangenberg C. … Lobbert R.W. (Genomics 1998) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. (PMID: 21107309) McClay J.L. … van den Oord E.J. (Neuropsychopharmacology 2011) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  5. Missense mutation in the tubulin-specific chaperone E (Tbce) gene in the mouse mutant progressive motor neuronopathy, a model of human motoneuron disease. (PMID: 12446740) Bommel H. … Sendtner M. (J. Cell Biol. 2002) 3

Products for GPR137B Gene

Sources for GPR137B Gene