Aliases for GPR137B Gene
Aliases for GPR137B Gene
External Ids for GPR137B Gene
- HGNC: 11862
- Entrez Gene: 7107
- Ensembl: ENSG00000077585
- OMIM: 604658
- UniProtKB: O60478
Previous HGNC Symbols for GPR137B Gene
- TM7SF1
Previous GeneCards Identifiers for GPR137B Gene
- GC01P232632
- GC01P234372
- GC01P236305
- GC01P206762
Summaries for GPR137B Gene
GeneCards Summary for GPR137B Gene
GPR137B (G Protein-Coupled Receptor 137B) is a Protein Coding gene. An important paralog of this gene is GPR137.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR137B Gene
Genomics for GPR137B Gene
Regulatory Elements for GPR137B Gene
Enhancers for GPR137B Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around GPR137B on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the GPR137B gene promoter:
Regulatory Element Products
Genomic Location for GPR137B Gene
- Chromosome:
- 1
- Start:
- 236,142,502 bp from pter
- End:
- 236,221,865 bp from pter
- Size:
- 79,364 bases
- Orientation:
- Plus strand
Genomic View for GPR137B Gene
Genes around GPR137B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q42.3 by Ensembl
- 1q42.3 by Entrez Gene
- 1q42.3 by HGNC
GPR137B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GPR137B Gene
Proteins for GPR137B Gene
-
Protein details for GPR137B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O60478-G137B_HUMAN
- Recommended name:
- Integral membrane protein GPR137B
- Protein Accession:
- O60478
- Q53EK7
- Q5TAE6
- Q6FHI3
Protein attributes for GPR137B Gene
- Size:
- 399 amino acids
- Molecular mass:
- 45599 Da
- Quaternary structure:
- No Data Available
Protein Expression for GPR137B Gene
Post-translational modifications for GPR137B Gene
Other Protein References for GPR137B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for GPR137B
- Invitrogen Antibodies for GPR137B
- GeneTex GPR137B antibody for GPR137B
Protein Products
-
OriGene Purified Proteins for GPR137B
- Search Origene for MassSpec and Protein Over-expression Lysates for GPR137B
- Origene Custom Protein Services for GPR137B
- Search GeneTex for Proteins for GPR137B
No data available for DME Specific Peptides for GPR137B Gene
Domains & Families for GPR137B Gene
Suggested Antigen Peptide Sequences for GPR137B Gene
Graphical View of Domain Structure for InterPro Entry
O60478- Family:
-
- Belongs to the GPR137 family.
No data available for Gene Families for GPR137B Gene
Function for GPR137B Gene
Phenotypes for GPR137B Gene
- GenomeRNAi human phenotypes for GPR137B:
Animal Model Products
-
Taconic Biosciences Mouse Models for GPR137B
- Cyagen custom Knockout/knockin (KOKI) mouse models for GPR137B
-
-
ViGene Biosciences lentiviral particle packaged cDNA for GPR137B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GPR137B gene
- Search ViGene Biosciences for GPR137B
CRISPR Products
-
OriGene CRISPR knockouts for GPR137B
-
Santa Cruz Biotechnology (SCBT) CRISPR for GPR137B
- GenScript: Design CRISPR guide RNA sequences for GPR137B
miRNA for GPR137B Gene
- miRTarBase miRNAs that target GPR137B
-
- hsa-mir-17-5p (MIRT000258)
- hsa-mir-181a-5p (MIRT025133)
- hsa-let-7d-5p (MIRT032128)
- hsa-mir-20a-5p (MIRT064435)
- hsa-mir-93-5p (MIRT064436)
- hsa-mir-106a-5p (MIRT064437)
- hsa-mir-106b-5p (MIRT064438)
- hsa-mir-20b-5p (MIRT064440)
- hsa-mir-526b-3p (MIRT064441)
- hsa-mir-519d-3p (MIRT064442)
- hsa-mir-548t-5p (MIRT064446)
- hsa-mir-548az-5p (MIRT064451)
- hsa-mir-183-3p (MIRT064453)
- hsa-mir-3609 (MIRT064456)
- hsa-mir-548ah-5p (MIRT064457)
- hsa-mir-19a-3p (MIRT134301)
- hsa-mir-19b-3p (MIRT134302)
- hsa-mir-7157-3p (MIRT572040)
- hsa-mir-6737-3p (MIRT572041)
- hsa-mir-5008-3p (MIRT572042)
- hsa-mir-6889-3p (MIRT572043)
- hsa-mir-586 (MIRT572044)
- hsa-mir-4796-3p (MIRT572045)
- hsa-mir-548n (MIRT572046)
- hsa-mir-7151-3p (MIRT684477)
- hsa-mir-5095 (MIRT684478)
- hsa-mir-5589-5p (MIRT684479)
- hsa-mir-4731-5p (MIRT684480)
- hsa-mir-6778-3p (MIRT684481)
- hsa-mir-6506-5p (MIRT684482)
- hsa-mir-619-5p (MIRT684483)
- hsa-mir-150-5p (MIRT684484)
- hsa-mir-7107-5p (MIRT684485)
- hsa-mir-1234-3p (MIRT684486)
- hsa-mir-186-3p (MIRT684487)
- hsa-mir-520h (MIRT684488)
- hsa-mir-520g-3p (MIRT684489)
- hsa-mir-512-3p (MIRT684490)
- hsa-mir-4438 (MIRT684491)
- hsa-mir-520e (MIRT684492)
- hsa-mir-520d-3p (MIRT684493)
- hsa-mir-520c-3p (MIRT684494)
- hsa-mir-520b (MIRT684495)
- hsa-mir-520a-3p (MIRT684496)
- hsa-mir-373-3p (MIRT684497)
- hsa-mir-372-3p (MIRT684498)
- hsa-mir-302e (MIRT684499)
- hsa-mir-302d-3p (MIRT684500)
- hsa-mir-302c-3p (MIRT684501)
- hsa-mir-302b-3p (MIRT684502)
- hsa-mir-302a-3p (MIRT684503)
- hsa-mir-6749-3p (MIRT693308)
- hsa-mir-7108-3p (MIRT693309)
- hsa-mir-4258 (MIRT693310)
miRNA Products
- Search ViGene Biosciences for GPR137B
Inhibitory RNA Products
- Origene shRNA, RNAi, and siRNA products in human, mouse, rat for GPR137B
- Browse OriGene Inhibitory RNA Products For GPR137B
-
ViGene Biosciences ready-to-package AAV shRNAs for GPR137B gene
Clone Products
-
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- Addgene plasmids for GPR137B
- VectorBuilder custom plasmid, inducible vectors for GPR137B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GPR137B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for GPR137B
-
ViGene Biosciences adenoviral particle packaged cDNA for GPR137B gene
-
ViGene Biosciences lentiviral particle packaged cDNA for GPR137B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GPR137B gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR137B Gene
Localization for GPR137B Gene
Subcellular locations from UniProtKB/Swiss-Prot for GPR137B Gene
- Lysosome membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| lysosome | 3 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005765 | lysosomal membrane | IEA | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 9521871 |
| GO:0016020 | membrane | TAS,IEA | 9521871 |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for GPR137B Gene
No Data Available
No data available for Pathways by source and SIGNOR curated interactions for GPR137B Gene
Transcripts for GPR137B Gene
mRNA/cDNA for GPR137B Gene
- (3) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (161) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GPR137B Gene
CRISPR Products
-
OriGene CRISPR knockouts for GPR137B
-
Santa Cruz Biotechnology (SCBT) CRISPR for GPR137B
- GenScript: Design CRISPR guide RNA sequences for GPR137B
miRNA Products
- Search ViGene Biosciences for GPR137B
Inhibitory RNA Products
- Origene shRNA, RNAi, and siRNA products in human, mouse, rat for GPR137B
- Browse OriGene Inhibitory RNA Products For GPR137B
-
ViGene Biosciences ready-to-package AAV shRNAs for GPR137B gene
Clone Products
-
OriGene ORF clones in human for GPR137B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for GPR137B
- VectorBuilder custom plasmid, inducible vectors for GPR137B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GPR137B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | · | 11d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||
| SP6: |
Expression for GPR137B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- Loop of Henle Cells Loop of Henle
- Proximal Tubule Cells Proximal Tubule
- Loop of Henle
- Proximal Tubule
- Epithelial Tubule
-
Epithelial Cells
- Loop of Henle Cells Loop of Henle
- Proximal Tubule Cells Proximal Tubule
- Eye (Sensory Organs)
This gene is overexpressed in Retina (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR137B Gene
NURSA nuclear receptor signaling pathways regulating expression of GPR137B Gene:
GPR137BSOURCE GeneReport for Unigene cluster for GPR137B Gene:
Hs.498160mRNA Expression by UniProt/SwissProt for GPR137B Gene:
O60478-G137B_HUMAN
Tissue specificity:
Expressed in kidney, heart, brain and placenta.
Evidence on tissue expression from TISSUES for GPR137B Gene
- Kidney(4.4)
- Skin(4.4)
- Spleen(4.2)
- Nervous system(3.5)
Primer Products
-
OriGene qPCR primer pairs and template standards for GPR137B
-
OriGene qPCR primer pairs for GPR137B
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR137B Gene
Orthologs for GPR137B Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GPR137B 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | GPR137B 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | GPR137B 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Gpr137b 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | GPR137B 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | GPR137B 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | GPR137B 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | GPR137B 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | gpr137b 34 |
|
||
| Str.3726 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | GPR137B (2 of 2) 35 |
|
OneToMany | |
| LOC100001171 34 |
|
||||
| GPR137B (1 of 2) 35 |
|
OneToMany | |||
| wufi39g02 34 |
|
- Species where no ortholog for GPR137B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for GPR137B Gene
(4) SIMAP similar genes for GPR137B Gene using alignment to 4 proteins:
Variants for GPR137B Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000033289 | -- | 236,196,529(+) | TTTAG(C/T)GGTGA | intron-variant | |
| rs1000039683 | -- | 236,188,531(+) | GAACG(A/G/T)GTGTT | intron-variant | |
| rs1000051492 | -- | 236,157,771(+) | AAAAA(A/C)ATCCA | intron-variant | |
| rs1000107230 | -- | 236,157,575(+) | CTACC(A/G)GTTGT | intron-variant | |
| rs1000195671 | -- | 236,181,252(+) | AGGTA(A/G)TGAAA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv156e212 | CNV | loss | 25503493 |
| dgv590n100 | CNV | gain | 25217958 |
| esv1123909 | CNV | insertion | 17803354 |
| esv28317 | CNV | loss | 19812545 |
| esv3345110 | CNV | duplication | 20981092 |
| esv3578490 | CNV | loss | 25503493 |
| esv3589211 | CNV | loss | 21293372 |
| nsv1005877 | CNV | gain | 25217958 |
| nsv1012436 | CNV | loss | 25217958 |
| nsv468428 | CNV | loss | 19166990 |
| nsv468439 | CNV | loss | 19166990 |
| nsv549394 | CNV | gain | 21841781 |
| nsv549397 | CNV | loss | 21841781 |
| nsv549398 | CNV | loss | 21841781 |
| nsv549399 | CNV | gain | 21841781 |
| nsv827476 | CNV | gain | 20364138 |
| nsv832969 | CNV | gain | 17160897 |
| nsv953998 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
48.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.27;
25.32% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for GPR137B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GPR137B
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR137B Gene
Disorders for GPR137B Gene
Relevant External Links for GPR137B
No disorders were found for GPR137B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR137B Gene
Publications for GPR137B Gene
- Cloning and characterization of a novel gene (TM7SF1) encoding a putative seven-pass transmembrane protein that is upregulated during kidney development. (PMID: 9521871) Spangenberg C. … Lobbert R.W. (Genomics 1998) 2 3 4 64
- Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. (PMID: 21107309) McClay J.L. … van den Oord E.J. (Neuropsychopharmacology 2011) 3 46 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
- TM7SF1 (GPR137B): a novel lysosome integral membrane protein. (PMID: 22729905) Gao J. … Wang L. (Mol. Biol. Rep. 2012) 4 64
Products for GPR137B Gene
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- Horizon Cell Lines for GPR137B
- Cyagen custom Knockout/knockin (KOKI) mouse models for GPR137B
- VectorBuilder custom plasmid, inducible vectors for GPR137B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GPR137B
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for GPR137B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
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