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Aliases for GPR137 Gene

Aliases for GPR137 Gene

  • G Protein-Coupled Receptor 137 2 3 5
  • Transmembrane 7 Superfamily Member 1-Like 1 Protein 3 4
  • TM7SF1L1 3 4
  • C11orf4 3 4
  • GPR137A 3 4
  • Integral Membrane Protein GPR137 3

External Ids for GPR137 Gene

Previous GeneCards Identifiers for GPR137 Gene

  • GC11P063810
  • GC11P064051
  • GC11P060379

Summaries for GPR137 Gene

GeneCards Summary for GPR137 Gene

GPR137 (G Protein-Coupled Receptor 137) is a Protein Coding gene. An important paralog of this gene is GPR137B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR137 Gene

Genomics for GPR137 Gene

Regulatory Elements for GPR137 Gene

Enhancers for GPR137 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F064320 0.5 ENCODE 12.1 +53.9 53860 5.3 HDAC1 KLF17 NFXL1 RAD21 ZNF366 SCRT2 EGR2 ZNF263 ZBTB2 CEBPB PLCB3 LOC102723878 TEX40 ENSG00000207024 KCNK4 KCNK4-TEX40 BAD GPR137 ENSG00000257086 TRMT112
GH11F064237 0.5 Ensembl ENCODE 11.6 -23.9 -23942 16.6 CREB3L1 MLX FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC SSRP1 TRPT1 PPP1R14B LOC102723878 VEGFB ENSG00000257086 MRPL49 TRMT112 KCNK4 ZFPL1 PLCB3
GH11F064215 0.6 ENCODE 11.6 -54.0 -54047 0.1 ZNF335 ZFHX2 HLF ZNF341 CEBPB FOS FKBP2 ENSG00000257086 LOC105369340 PPP1R14B PLCB3 GPR137 BAD MACROD1 FERMT3 NUDT22
GH11F064205 0.4 ENCODE 11.6 -61.7 -61665 4.4 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 TRPT1 PLCB3 TRMT112 ZFPL1 ENSG00000257086 GPR137 BAD KCNK4-TEX40 KCNK4 ENSG00000207024
GH11F064347 0.6 ENCODE 11.4 +79.1 79122 1.9 BCOR KLF1 JUN CHD4 ZMYM3 MAX CEBPG ZNF366 POLR2A PATZ1 LOC102723878 MIR1237 PRDX5 TRMT112 ESRRA TEX40 ENSG00000207024 KCNK4 KCNK4-TEX40 BAD
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GPR137 on UCSC Golden Path with GeneCards custom track

Promoters for GPR137 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for GPR137 Gene

64,269,260 bp from pter
64,289,500 bp from pter
20,241 bases
Plus strand

Genomic View for GPR137 Gene

Genes around GPR137 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR137 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR137 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR137 Gene

Proteins for GPR137 Gene

  • Protein details for GPR137 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Integral membrane protein GPR137
    Protein Accession:
    Secondary Accessions:
    • B4DTG7
    • B7Z7M1
    • Q4G0Y9
    • Q8N4K6

    Protein attributes for GPR137 Gene

    417 amino acids
    Molecular mass:
    46059 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GPR137 Gene


neXtProt entry for GPR137 Gene

Post-translational modifications for GPR137 Gene

  • Glycosylation at Asn 4 and Asn 257
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPR137 Gene

Domains & Families for GPR137 Gene

Gene Families for GPR137 Gene

Protein Domains for GPR137 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GPR137 family.
  • Belongs to the GPR137 family.
genes like me logo Genes that share domains with GPR137: view

Function for GPR137 Gene

genes like me logo Genes that share phenotypes with GPR137: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR137

miRNA for GPR137 Gene

miRTarBase miRNAs that target GPR137

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR137 Gene

Localization for GPR137 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR137 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GPR137 Gene COMPARTMENTS Subcellular localization image for GPR137 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for GPR137 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR137: view

Pathways & Interactions for GPR137 Gene

SuperPathways for GPR137 Gene

No Data Available

Interacting Proteins for GPR137 Gene

Gene Ontology (GO) - Biological Process for GPR137 Gene


No data available for Pathways by source and SIGNOR curated interactions for GPR137 Gene

Transcripts for GPR137 Gene

Unigene Clusters for GPR137 Gene

G protein-coupled receptor 137:
Representative Sequences:

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR137 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b
SP1: - - - - - - - - -
SP2: -
SP3: - -
SP4: - - - - - - - - - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - -
SP9: -
SP11: - - -

Relevant External Links for GPR137 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR137 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR137 Gene

mRNA differential expression in normal tissues according to GTEx for GPR137 Gene

This gene is overexpressed in Testis (x6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR137 Gene

Protein tissue co-expression partners for GPR137 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPR137 Gene:


SOURCE GeneReport for Unigene cluster for GPR137 Gene:

genes like me logo Genes that share expression patterns with GPR137: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GPR137 Gene

Orthologs for GPR137 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR137 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR137 34 35
  • 99.83 (n)
(Canis familiaris)
Mammalia GPR137 34 35
  • 91.25 (n)
(Bos Taurus)
Mammalia GPR137 34 35
  • 91.05 (n)
(Rattus norvegicus)
Mammalia Gpr137 34
  • 89.39 (n)
(Mus musculus)
Mammalia Gpr137 34 16 35
  • 88.89 (n)
(Monodelphis domestica)
Mammalia GPR137 35
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia GPR137 35
  • 70 (a)
(Anolis carolinensis)
Reptilia GPR137 35
  • 61 (a)
(Danio rerio)
Actinopterygii GPR137 (1 of 2) 35
  • 51 (a)
gpr137 35
  • 46 (a)
Species where no ortholog for GPR137 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR137 Gene

Gene Tree for GPR137 (if available)
Gene Tree for GPR137 (if available)

Paralogs for GPR137 Gene

Paralogs for GPR137 Gene

genes like me logo Genes that share paralogs with GPR137: view

Variants for GPR137 Gene

Sequence variations from dbSNP and Humsavar for GPR137 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1050029 -- 64,269,939(-) CTGCG(C/T)TAAGT downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs10556 -- 64,269,935(-) GCTAA(A/G)TCGCG downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs1058388 -- 64,288,433(+) TGGTG(G/T)GCTTC reference, missense
rs10897479 -- 64,271,296(+) GACTc(A/T)cacac intron-variant
rs10897480 -- 64,274,664(+) AAAAA(C/T)ACAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR137 Gene

Variant ID Type Subtype PubMed ID
dgv1963n54 CNV loss 21841781
esv3626658 CNV loss 21293372
nsv357 CNV insertion 18451855
nsv469961 CNV loss 18288195
nsv832186 CNV loss 17160897
nsv951010 CNV deletion 24416366

Variation tolerance for GPR137 Gene

Residual Variation Intolerance Score: 21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR137 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR137 Gene

Disorders for GPR137 Gene

Relevant External Links for GPR137

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GPR137 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR137 Gene

Publications for GPR137 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Characterization of five novel human genes in the 11q13-q22 region. (PMID: 10873569) O'Brien K.P. … Dumanski J.P. (Biochem. Biophys. Res. Commun. 2000) 2 3 64
  4. G-protein-coupled receptor 137 accelerates proliferation of urinary bladder cancer cells in vitro. (PMID: 25496438) Du Y. … Liu H. (Biotechnol. Appl. Biochem. 2015) 3 64
  5. Knockdown of GPR137 by RNAi inhibits pancreatic cancer cell growth and induces apoptosis. (PMID: 25471990) Cui X. … Qin C. (Biotechnol. Appl. Biochem. 2015) 3 64

Products for GPR137 Gene

Sources for GPR137 Gene

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