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Aliases for GPR137 Gene

Aliases for GPR137 Gene

  • G Protein-Coupled Receptor 137 2 3 5
  • Transmembrane 7 Superfamily Member 1-Like 1 Protein 3 4
  • TM7SF1L1 3 4
  • C11orf4 3 4
  • GPR137A 3 4
  • Integral Membrane Protein GPR137 3

External Ids for GPR137 Gene

Previous GeneCards Identifiers for GPR137 Gene

  • GC11P063810
  • GC11P064051
  • GC11P060379

Summaries for GPR137 Gene

GeneCards Summary for GPR137 Gene

GPR137 (G Protein-Coupled Receptor 137) is a Protein Coding gene. An important paralog of this gene is GPR137B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR137 Gene

Genomics for GPR137 Gene

Regulatory Elements for GPR137 Gene

Enhancers for GPR137 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around GPR137 on UCSC Golden Path with GeneCards custom track

Promoters for GPR137 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for GPR137 Gene

64,269,260 bp from pter
64,289,500 bp from pter
20,241 bases
Plus strand

Genomic View for GPR137 Gene

Genes around GPR137 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR137 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR137 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR137 Gene

Proteins for GPR137 Gene

  • Protein details for GPR137 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Integral membrane protein GPR137
    Protein Accession:
    Secondary Accessions:
    • B4DTG7
    • B7Z7M1
    • Q4G0Y9
    • Q8N4K6

    Protein attributes for GPR137 Gene

    417 amino acids
    Molecular mass:
    46059 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GPR137 Gene


neXtProt entry for GPR137 Gene

Post-translational modifications for GPR137 Gene

  • Glycosylation at Asn 4 and Asn 257
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPR137 Gene

Domains & Families for GPR137 Gene

Gene Families for GPR137 Gene

Protein Domains for GPR137 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GPR137 family.
  • Belongs to the GPR137 family.
genes like me logo Genes that share domains with GPR137: view

Function for GPR137 Gene

genes like me logo Genes that share phenotypes with GPR137: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR137

CRISPR Products

miRNA for GPR137 Gene

miRTarBase miRNAs that target GPR137

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR137 Gene

Localization for GPR137 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR137 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GPR137 Gene COMPARTMENTS Subcellular localization image for GPR137 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for GPR137 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR137: view

Pathways & Interactions for GPR137 Gene

SuperPathways for GPR137 Gene

No Data Available

Interacting Proteins for GPR137 Gene

Gene Ontology (GO) - Biological Process for GPR137 Gene


No data available for Pathways by source and SIGNOR curated interactions for GPR137 Gene

Drugs & Compounds for GPR137 Gene

No Compound Related Data Available

Transcripts for GPR137 Gene

Unigene Clusters for GPR137 Gene

G protein-coupled receptor 137:
Representative Sequences:

CRISPR Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR137 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b
SP1: - - - - - - - - -
SP2: -
SP3: - -
SP4: - - - - - - - - - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - -
SP9: -
SP11: - - -

Relevant External Links for GPR137 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR137 Gene

mRNA expression in normal human tissues for GPR137 Gene

mRNA differential expression in normal tissues according to GTEx for GPR137 Gene

This gene is overexpressed in Testis (x6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR137 Gene

Protein tissue co-expression partners for GPR137 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPR137 Gene:


SOURCE GeneReport for Unigene cluster for GPR137 Gene:

genes like me logo Genes that share expression patterns with GPR137: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GPR137 Gene

Orthologs for GPR137 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR137 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPR137 34
  • 91.05 (n)
  • 96.46 (a)
GPR137 35
  • 86 (a)
(Canis familiaris)
Mammalia GPR137 34
  • 91.25 (n)
  • 96.72 (a)
GPR137 35
  • 81 (a)
(Mus musculus)
Mammalia Gpr137 34
  • 88.89 (n)
  • 95.2 (a)
Gpr137 16
Gpr137 35
  • 85 (a)
(Pan troglodytes)
Mammalia GPR137 34
  • 99.83 (n)
  • 100 (a)
GPR137 35
  • 100 (a)
(Rattus norvegicus)
Mammalia Gpr137 34
  • 89.39 (n)
  • 95.2 (a)
(Monodelphis domestica)
Mammalia GPR137 35
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia GPR137 35
  • 70 (a)
(Anolis carolinensis)
Reptilia GPR137 35
  • 61 (a)
(Danio rerio)
Actinopterygii gpr137 35
  • 46 (a)
GPR137 (1 of 2) 35
  • 51 (a)
Species where no ortholog for GPR137 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR137 Gene

Gene Tree for GPR137 (if available)
Gene Tree for GPR137 (if available)

Paralogs for GPR137 Gene

Paralogs for GPR137 Gene

genes like me logo Genes that share paralogs with GPR137: view

Variants for GPR137 Gene

Sequence variations from dbSNP and Humsavar for GPR137 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1058388 -- 64,288,433(+) TGGTG(G/T)GCTTC reference, missense
rs34193151 -- 64,287,854(+) CGACT(-/A)CCCTG reference, frameshift-variant
rs34943349 -- 64,287,253(+) CATCC(A/C)CCATG intron-variant
rs138768975 -- 64,286,997(+) CGGCC(A/G)GAGAT reference, synonymous-codon
rs139070739 -- 64,288,797(+) GGGAC(C/T)GAGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR137 Gene

Variant ID Type Subtype PubMed ID
dgv1963n54 CNV loss 21841781
esv3626658 CNV loss 21293372
nsv357 CNV insertion 18451855
nsv469961 CNV loss 18288195
nsv832186 CNV loss 17160897
nsv951010 CNV deletion 24416366

Variation tolerance for GPR137 Gene

Residual Variation Intolerance Score: 21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR137 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR137 Gene

Disorders for GPR137 Gene

Relevant External Links for GPR137

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GPR137 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR137 Gene

Publications for GPR137 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. Characterization of five novel human genes in the 11q13-q22 region. (PMID: 10873569) O'Brien K.P. … Dumanski J.P. (Biochem. Biophys. Res. Commun. 2000) 2 3 65
  4. Down-regulation of G protein-coupled receptor 137 by RNA interference inhibits cell growth of two hepatoma cell lines. (PMID: 25490967) Shao X. … Ge X. (Cell Biol. Int. 2015) 3 65
  5. Inhibition of GPR137 expression reduces the proliferation and colony formation of malignant glioma cells. (PMID: 24870220) Zong G. … Zhao B. (Neurol. Sci. 2014) 3 65

Products for GPR137 Gene

Sources for GPR137 Gene

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