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Aliases for GPR137 Gene

Aliases for GPR137 Gene

  • G Protein-Coupled Receptor 137 2 3 5
  • Transmembrane 7 Superfamily Member 1-Like 1 Protein 3 4
  • TM7SF1L1 3 4
  • C11orf4 3 4
  • GPR137A 3 4
  • Integral Membrane Protein GPR137 3

External Ids for GPR137 Gene

Previous GeneCards Identifiers for GPR137 Gene

  • GC11P063810
  • GC11P064051
  • GC11P060379

Summaries for GPR137 Gene

GeneCards Summary for GPR137 Gene

GPR137 (G Protein-Coupled Receptor 137) is a Protein Coding gene. An important paralog of this gene is GPR137B.

Additional gene information for GPR137 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR137 Gene

Genomics for GPR137 Gene

GeneHancer (GH) Regulatory Elements for GPR137 Gene

Promoters and enhancers for GPR137 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I064282 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.4 +15.6 15557 3.8 HDGF PKNOX1 ARID4B SIN3A YY1 SLC30A9 POLR2B ZNF766 ZNF213 E2F8 BAD GPR137 LOC102723878 SF1 TRMT112 POLA2 ZFPL1 ZNHIT2 PLCB3 ENSG00000257086
GH11I064267 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 550.8 +1.4 1440 7.2 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 MCM3 SP3 NFYC GPR137 ZFPL1 SF1 POLA2 PLCB3 TRMT112 DNAJC4 ENSG00000257086 FAU LOC102723878
GH11I064237 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.6 -23.9 -23941 16.6 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC PPP1R14B FKBP2 LOC105369340 PLCB3 TRPT1 LOC102723878 VEGFB TRMT112 FERMT3 GPR137
GH11I064205 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.6 -61.7 -61665 4.4 HDGF PKNOX1 ATF1 SMAD1 ARNT YY1 TCF12 POLR2B ZNF766 ZNF143 FERMT3 TRPT1 ZFPL1 PLCB3 SF1 TRMT112 ENSG00000257086 GPR137 BAD KCNK4
GH11I064320 Enhancer 1.1 Ensembl ENCODE dbSUPER 12.1 +53.9 53860 5.3 ZNF449 NFXL1 ZIC2 ZKSCAN1 EGR1 POLR2A EGR2 ZBTB2 MTA2 CBFA2T3 PLCB3 LOC102723878 CATSPERZ ENSG00000207024 KCNK4 KCNK4-TEX40 BAD GPR137 ENSG00000257086 TRMT112
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GPR137 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR137 gene promoter:

Genomic Locations for GPR137 Gene

Genomic Locations for GPR137 Gene
chr11:64,269,260-64,289,500
(GRCh38/hg38)
Size:
20,241 bases
Orientation:
Plus strand
chr11:64,037,534-64,056,972
(GRCh37/hg19)

Genomic View for GPR137 Gene

Genes around GPR137 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR137 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR137 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR137 Gene

Proteins for GPR137 Gene

  • Protein details for GPR137 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96N19-G137A_HUMAN
    Recommended name:
    Integral membrane protein GPR137
    Protein Accession:
    Q96N19
    Secondary Accessions:
    • B4DTG7
    • B7Z7M1
    • Q4G0Y9
    • Q8N4K6

    Protein attributes for GPR137 Gene

    Size:
    417 amino acids
    Molecular mass:
    46059 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GPR137 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPR137 Gene

Post-translational modifications for GPR137 Gene

  • Glycosylation at isoforms=2, 3, 4, 54 and isoforms=2, 4, 5257

No data available for DME Specific Peptides for GPR137 Gene

Domains & Families for GPR137 Gene

Gene Families for GPR137 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for GPR137 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96N19

UniProtKB/Swiss-Prot:

G137A_HUMAN :
  • Belongs to the GPR137 family.
Family:
  • Belongs to the GPR137 family.
genes like me logo Genes that share domains with GPR137: view

Function for GPR137 Gene

Phenotypes From GWAS Catalog for GPR137 Gene

genes like me logo Genes that share phenotypes with GPR137: view

miRNA for GPR137 Gene

miRTarBase miRNAs that target GPR137

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR137 Gene

Localization for GPR137 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR137 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR137 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPR137 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR137: view

Pathways & Interactions for GPR137 Gene

SuperPathways for GPR137 Gene

No Data Available

Interacting Proteins for GPR137 Gene

Gene Ontology (GO) - Biological Process for GPR137 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GPR137 Gene

Drugs & Compounds for GPR137 Gene

No Compound Related Data Available

Transcripts for GPR137 Gene

Unigene Clusters for GPR137 Gene

G protein-coupled receptor 137:
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR137 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b
SP1: - - - - - - - - -
SP2: -
SP3: - -
SP4: - - - - - - - - - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - -
SP8:
SP9: -
SP10:
SP11: - - -

Relevant External Links for GPR137 Gene

GeneLoc Exon Structure for
GPR137
ECgene alternative splicing isoforms for
GPR137

Expression for GPR137 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR137 Gene

mRNA differential expression in normal tissues according to GTEx for GPR137 Gene

This gene is overexpressed in Testis (x6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR137 Gene



Protein tissue co-expression partners for GPR137 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPR137 Gene:

GPR137

SOURCE GeneReport for Unigene cluster for GPR137 Gene:

Hs.523763

Evidence on tissue expression from TISSUES for GPR137 Gene

  • Pancreas(4.3)
genes like me logo Genes that share expression patterns with GPR137: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR137 Gene

Orthologs for GPR137 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR137 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR137 33 34
  • 99.83 (n)
dog
(Canis familiaris)
Mammalia GPR137 33 34
  • 91.25 (n)
cow
(Bos Taurus)
Mammalia GPR137 33 34
  • 91.05 (n)
rat
(Rattus norvegicus)
Mammalia Gpr137 33
  • 89.39 (n)
mouse
(Mus musculus)
Mammalia Gpr137 33 16 34
  • 88.89 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR137 34
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR137 34
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR137 34
  • 61 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii GPR137 (1 of 2) 34
  • 51 (a)
OneToMany
gpr137 34
  • 46 (a)
OneToMany
Species where no ortholog for GPR137 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR137 Gene

ENSEMBL:
Gene Tree for GPR137 (if available)
TreeFam:
Gene Tree for GPR137 (if available)

Paralogs for GPR137 Gene

Paralogs for GPR137 Gene

genes like me logo Genes that share paralogs with GPR137: view

Variants for GPR137 Gene

Sequence variations from dbSNP and Humsavar for GPR137 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000009542 -- 64,272,887(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000679595 -- 64,276,575(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000873868 -- 64,270,016(+) C/A upstream_transcript_variant
rs1000999174 -- 64,286,294(+) T/G 5_prime_UTR_variant, intron_variant
rs1001012410 -- 64,273,643(+) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GPR137 Gene

Variant ID Type Subtype PubMed ID
dgv1963n54 CNV loss 21841781
esv3626658 CNV loss 21293372
nsv357 CNV insertion 18451855
nsv469961 CNV loss 18288195
nsv832186 CNV loss 17160897
nsv951010 CNV deletion 24416366

Variation tolerance for GPR137 Gene

Residual Variation Intolerance Score: 21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR137 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR137

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR137 Gene

Disorders for GPR137 Gene

Additional Disease Information for GPR137

No disorders were found for GPR137 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR137 Gene

Publications for GPR137 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Characterization of five novel human genes in the 11q13-q22 region. (PMID: 10873569) O'Brien KP … Dumanski JP (Biochemical and biophysical research communications 2000) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Knockdown of GPR137,G Protein-coupled receptor 137, Inhibits the Proliferation and Migration of Human Prostate Cancer Cells. (PMID: 26669804) Ren J … Xu D (Chemical biology & drug design 2016) 3 58

Products for GPR137 Gene

Sources for GPR137 Gene

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