GPR137 Gene
protein-coding GIFtS: 40
GCID: GC11P064051
|
|
G protein-coupled receptor 137
| |
Aliases
for GPR137 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| G Protein-Coupled Receptor 1371 2 | | C11orf41 2 3 | | GPR137A1 2 3 | | TM7SF1L11 2 3 | | Transmembrane 7 Superfamily Member 1-Like 1 Protein2 3 | | Integral Membrane Protein GPR1372 |
| External Ids: | HGNC: 243001 | Entrez Gene: 568342 | Ensembl: ENSG000001732647 | UniProtKB: Q96N193 | | ORGUL members: | |
|---|
| NONCODE:n341046 | |
Export aliases for GPR137 gene to outside databasesPrevious GC identifers: GC11P063810 GC11P060379
|---|
Summaries
for GPR137 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for GPR137 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GPR137 gene promoter:
CREB ATF-2 deltaCREB c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for GPR137
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPR137 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11cen-q22.3 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11cen-q22.3GPR137 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P064051: view genomic region
(about GC identifiers)
Start:
|
64,037,534 bp from pter |
End:
|
64,056,972 bp from pter |
Size:
|
19,439 bases |
Orientation:
|
plus strand |
|
Proteins
for GPR137 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: G137A_HUMAN, Q96N19 (See
protein sequence)Recommended Name: Integral membrane protein GPR137 Size: 417 amino acids; 46059 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: B4DTG7 B7Z7M1 Q4G0Y9 Q8N4K6Alternative splicing: 5 isoforms: Q96N19-1 Q96N19-2 Q96N19-3 Q96N19-4 Q96N19-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for GPR137: NX_Q96N19
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96N19
GPR137 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001164197.1 NP_001164351.1 NP_001164352.1 NP_001170829.1 NP_064540.3
ENSEMBL proteins: ENSP00000445570 ENSP00000442322 ENSP00000411827 ENSP00000440928 ENSP00000438716 ENSP00000438146 ENSP00000366931 ENSP00000446342 ENSP00000441003 ENSP00000445000 ENSP00000446387 ENSP00000415698 ENSP00000321698 ENSP00000441034 ENSP00000442929 ENSP00000443443 ENSP00000442792
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
GPR137 for ontologies About GeneDecksing
GPR137 Antibody Products:
Assay Products for GPR137: |
Protein
Domains /
Families
for GPR137 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GPR137 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96N19ProtoNet protein and cluster: Q96N19 UniProtKB/Swiss-Prot: G137A_HUMAN, Q96N19Similarity: Belongs to the GPR137 family |
Function
for GPR137 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPR137 (see all 10)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPR137 (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: GPR137 (NM_003272) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GPR137 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPR137 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR137 |
1 GenomeRNAi human phenotype for GPR137:
|
Pathways & Interactions
for GPR137 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GPR137
|
Drugs & Compounds
for GPR137 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for GPR137
Search CenterWatch for drugs/clinical trials and news about GPR137 / G137A
|
Transcripts
for GPR137 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GPR137 gene (5 alternative transcripts): NM_001170726.1 NM_001170880.1 NM_001170881.1 NM_001177358.1 NM_020155.3 Unigene Cluster for GPR137: G protein-coupled receptor 137 Hs.523763 [show with all ESTs]Unigene Representative Sequence: NM_00117088118/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19): ENST00000546139 ENST00000538244 ENST00000411458(uc010rni.2) ENST00000536667
ENST00000539833 ENST00000546201 ENST00000377702 ENST00000535675 ENST00000543383
ENST00000538032 ENST00000540370 ENST00000536017(uc001nzh.2) ENST00000438980(uc001nzi.3 uc021qkt.1)
ENST00000313074 ENST00000542190 ENST00000541952 ENST00000545366 ENST00000536282
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPR137 (see all 10)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPR137 (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: GPR137 (NM_003272) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GPR137 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPR137 |
Additional cDNA sequence: AJ250392.1 AK056094.1 AK300209.1 AK302256.1 BC020396.1 BC029297.1 BC033920.1 BC035002.1 20 DOTS entries: DT.97760032 DT.455273 DT.95115779 DT.100839742 DT.91792789 DT.95115780 DT.95363584 DT.101978224 DT.86846333 DT.75157638 DT.97760031 DT.120716511 DT.91742507 DT.92363242 DT.100781618 DT.120716468 DT.120716513 DT.95115777 DT.99951516 DT.92026158 24/190 AceView cDNA sequences (see all 190): AA809942 BU689814 BQ944575 BC020396 BM705470 AI151232 AI567943 BM694388 BQ880778 BQ673174 AW006233 BI850672 BM503899 BI862163 AI269136 CA771195 BQ961897 AI245640 BU150427 BU501857 BU581377 BF732391 BC029297 BC035002
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for GPR137 (see all 11) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b |
|---|
|
| SP1: | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | |
| SP4: | | | - | | - | | - | | - | | - | | - | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for GPR137
|
Expression
for GPR137 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GPR137 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCTGCCACC
About this image
See GPR137 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GPR137
SOURCE GeneReport for Unigene cluster: Hs.523763
SABiosciences Custom PCR Arrays for GPR137
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GPR137
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GPR137 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPR137 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPR137 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR137 |
Orthologs
for GPR137 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for GPR137 gene from 2/11 species (see all 11) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
GPR1376 |
-- |
65(a) |
1 ↔ 1 |
GL344419.1(1439-11735) |
zebrafish
(Danio rerio) |
Actinopterygii |
gpr1376 |
G protein-coupled receptor 137 |
45(a) |
1 ↔ 1 |
14(27448325-27459799) |
ENSEMBL Gene Tree for GPR137 (if available)
TreeFam Gene Tree for GPR137 (if available) |
Paralogs
for GPR137 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GPR137 gene
- GPR137B2 GPR137C2
4 SIMAP similar genes for GPR137 using alignment to 14 protein entries: G137A_HUMAN (see all proteins):ORF4 GPR137B DKFZp686N01223 GPR137C
GPR137 for paralogs About GeneDecksing
|
Genomic Variants
for GPR137 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GPR137 (64037534 - 64056972 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GPR137: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GPR137 |
|
Disorders
/ Diseases
for GPR137 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for GPR137 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GPR137 gene integrated from 9 sources:
(articles sorted by number of sources associating them with GPR137) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Characterization of five novel human genes in the 11q13-q22 region. (PubMed id 10873569)1, 3 O'Brien K.P....Dumanski J.P. (2000)
- A novel sarcoidosis risk locus for Europeans on chromo some 11q13.1. (PubMed id 22837380)1 Fischer A....Schreiber S. (2012)
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
- Novel human G-protein-coupled receptors. (PubMed id 12732197)3 Vanti W.B....O'Dowd B.F. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
|
External Searches for GPR137 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GPR137 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GPR137 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GPR137 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GPR137 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for GPR137 gene:
Search GeneIP for patents involving GPR137
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GPR137 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for GPR137 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GPR137 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GPR137 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for GPR137 | | OriGene 3'-UTR Clone for GPR137 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPR137 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPR137 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GPR137 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GPR137 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPR137 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GPR137 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPR137 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPR137 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for GPR137 |
| |  |  |  |  | | | | |
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 | | | GPR137 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR137 |
|  |  |  | | | | Search ThermoFisher Antibodies for GPR137 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPR137 |
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