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Aliases for GPR137 Gene

Aliases for GPR137 Gene

  • G Protein-Coupled Receptor 137 2 3
  • Transmembrane 7 Superfamily Member 1-Like 1 Protein 3 4
  • TM7SF1L1 3 4
  • C11orf4 3 4
  • GPR137A 3 4

External Ids for GPR137 Gene

Previous GeneCards Identifiers for GPR137 Gene

  • GC11P063810
  • GC11P064051
  • GC11P060379

Summaries for GPR137 Gene

GeneCards Summary for GPR137 Gene

GPR137 (G Protein-Coupled Receptor 137) is a Protein Coding gene. An important paralog of this gene is GPR137B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR137 Gene

Genomics for GPR137 Gene

Regulatory Elements for GPR137 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GPR137 Gene

64,269,260 bp from pter
64,289,500 bp from pter
20,241 bases
Plus strand

Genomic View for GPR137 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPR137 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR137 Gene

Proteins for GPR137 Gene

  • Protein details for GPR137 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Integral membrane protein GPR137
    Protein Accession:
    Secondary Accessions:
    • B4DTG7
    • B7Z7M1
    • Q4G0Y9
    • Q8N4K6

    Protein attributes for GPR137 Gene

    417 amino acids
    Molecular mass:
    46059 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GPR137 Gene


neXtProt entry for GPR137 Gene

Proteomics data for GPR137 Gene at MOPED

Post-translational modifications for GPR137 Gene

  • Glycosylation at Asn 4 and Asn 257
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPR137 Gene

Domains & Families for GPR137 Gene

Gene Families for GPR137 Gene

Protein Domains for GPR137 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GPR137 family.
  • Belongs to the GPR137 family.
genes like me logo Genes that share domains with GPR137: view

Function for GPR137 Gene

Phenotypes for GPR137 Gene

GenomeRNAi human phenotypes for GPR137:
genes like me logo Genes that share phenotypes with GPR137: view

Animal Model Products

miRNA for GPR137 Gene

miRTarBase miRNAs that target GPR137

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR137 Gene

Localization for GPR137 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR137 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GPR137 Gene COMPARTMENTS Subcellular localization image for GPR137 gene
Compartment Confidence
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for GPR137 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR137: view

Pathways & Interactions for GPR137 Gene

SuperPathways for GPR137 Gene

No Data Available

Interacting Proteins for GPR137 Gene

Gene Ontology (GO) - Biological Process for GPR137 Gene


No data available for Pathways by source and SIGNOR curated interactions for GPR137 Gene

Drugs & Compounds for GPR137 Gene

No Compound Related Data Available

Transcripts for GPR137 Gene

Unigene Clusters for GPR137 Gene

G protein-coupled receptor 137:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPR137

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR137 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b
SP1: - - - - - - - - -
SP2: -
SP3: - -
SP4: - - - - - - - - - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - -
SP9: -
SP11: - - -

Relevant External Links for GPR137 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR137 Gene

mRNA expression in normal human tissues for GPR137 Gene

mRNA differential expression in normal tissues according to GTEx for GPR137 Gene

This gene is overexpressed in Testis (x6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR137 Gene

SOURCE GeneReport for Unigene cluster for GPR137 Gene Hs.523763

genes like me logo Genes that share expression patterns with GPR137: view

Protein tissue co-expression partners for GPR137 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GPR137 Gene

Orthologs for GPR137 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR137 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPR137 35
  • 91.05 (n)
  • 96.46 (a)
GPR137 36
  • 86 (a)
(Canis familiaris)
Mammalia GPR137 35
  • 91.25 (n)
  • 96.72 (a)
GPR137 36
  • 81 (a)
(Mus musculus)
Mammalia Gpr137 35
  • 88.89 (n)
  • 95.2 (a)
Gpr137 16
Gpr137 36
  • 85 (a)
(Pan troglodytes)
Mammalia GPR137 35
  • 99.83 (n)
  • 100 (a)
GPR137 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Gpr137 35
  • 89.39 (n)
  • 95.2 (a)
(Monodelphis domestica)
Mammalia GPR137 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia GPR137 36
  • 70 (a)
(Anolis carolinensis)
Reptilia GPR137 36
  • 61 (a)
(Danio rerio)
Actinopterygii gpr137 36
  • 46 (a)
GPR137 (1 of 2) 36
  • 51 (a)
Species with no ortholog for GPR137:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR137 Gene

Gene Tree for GPR137 (if available)
Gene Tree for GPR137 (if available)

Paralogs for GPR137 Gene

Paralogs for GPR137 Gene

genes like me logo Genes that share paralogs with GPR137: view

Variants for GPR137 Gene

Sequence variations from dbSNP and Humsavar for GPR137 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1058388 -- 64,288,433(+) TGGTG(G/T)GCTTC reference, missense
rs3782103 -- 64,287,339(+) CCCTC(A/G)TCATT intron-variant
rs34193151 -- 64,287,854(+) CGACT(-/A)CCCTG reference, frameshift-variant
rs34943349 -- 64,287,253(+) CATCC(A/C)CCATG intron-variant
rs36094737 -- 64,288,039(+) CCTGA(-/G)GGTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR137 Gene

Variant ID Type Subtype PubMed ID
dgv1156n71 CNV Loss 21882294
nsv469961 CNV Loss 18288195
dgv1163n71 CNV Loss 21882294
dgv1165n71 CNV Loss 21882294
dgv1166n71 CNV Loss 21882294
nsv832186 CNV Loss 17160897
nsv897684 CNV Loss 21882294
nsv897685 CNV Loss 21882294
dgv1168n71 CNV Loss 21882294
nsv357 CNV Insertion 18451855

Variation tolerance for GPR137 Gene

Residual Variation Intolerance Score: 21.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR137 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR137 Gene

Disorders for GPR137 Gene

Relevant External Links for GPR137

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GPR137: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR137 Gene

Publications for GPR137 Gene

  1. Novel human G-protein-coupled receptors. (PMID: 12732197) Vanti W.B. … O'Dowd B.F. (Biochem. Biophys. Res. Commun. 2003) 2 67
  2. Characterization of five novel human genes in the 11q13-q22 region. (PMID: 10873569) O'Brien K.P. … Dumanski J.P. (Biochem. Biophys. Res. Commun. 2000) 2 67
  3. Down-regulation of GPR137 expression inhibits proliferation of colon cancer cells. (PMID: 25301753) Zhang K. … Jiang Y. (Acta Biochim. Biophys. Sin. (Shanghai) 2014) 67
  4. A novel sarcoidosis risk locus for Europeans on chromosome 11q13.1. (PMID: 22837380) Fischer A. … Schreiber S. (Am. J. Respir. Crit. Care Med. 2012) 67
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 67

Products for GPR137 Gene

Sources for GPR137 Gene

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