Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GPR137 Gene

Aliases for GPR137 Gene

  • G Protein-Coupled Receptor 137 2 3 5
  • Transmembrane 7 Superfamily Member 1-Like 1 Protein 3 4
  • TM7SF1L1 3 4
  • C11orf4 3 4
  • GPR137A 3 4
  • Integral Membrane Protein GPR137 3

External Ids for GPR137 Gene

Previous GeneCards Identifiers for GPR137 Gene

  • GC11P063810
  • GC11P064051
  • GC11P060379

Summaries for GPR137 Gene

GeneCards Summary for GPR137 Gene

GPR137 (G Protein-Coupled Receptor 137) is a Protein Coding gene. An important paralog of this gene is GPR137B.

Additional gene information for GPR137 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR137 Gene

Genomics for GPR137 Gene

Regulatory Elements for GPR137 Gene

Enhancers for GPR137 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H064237 1.4 ENCODE dbSUPER 11.6 -23.9 -23942 16.6 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZBTB7B TRPT1 PPP1R14B LOC102723878 VEGFB ENSG00000257086 TRMT112 SF1 ZFPL1 PLCB3 FERMT3
GH11H064205 1.3 ENCODE dbSUPER 11.6 -61.7 -61665 4.4 HDGF PKNOX1 ATF1 ARNT SIN3A YY1 TCF12 ZNF766 ELK1 ZNF143 TRPT1 ZFPL1 PLCB3 SF1 TRMT112 ENSG00000257086 GPR137 BAD KCNK4-TEX40 KCNK4
GH11H064320 1.2 Ensembl ENCODE dbSUPER 12.1 +53.9 53860 5.3 MTA2 ZBTB2 NFXL1 ZIC2 ZKSCAN1 POLR2A EGR1 GLIS1 TARDBP PRDM1 PLCB3 LOC102723878 CATSPERZ ENSG00000207024 KCNK4 KCNK4-TEX40 BAD GPR137 ENSG00000257086 TRMT112
GH11H064204 1 ENCODE 11.3 -64.6 -64577 1.2 HDGF ATF1 ARNT ZNF2 ZNF143 ATF7 RUNX3 DEK ZC3H11A REST TRPT1 NUDT22 DNAJC4 ENSG00000257086 PLCB3 MACROD1 GPR137 BAD FERMT3 GC11M064182
GH11H064347 0.8 ENCODE 11.4 +79.1 79122 1.9 BCOR KLF1 JUN CHD4 ZMYM3 MAX CEBPG POLR2A FOXK2 PATZ1 LOC102723878 MIR1237 TRMT112 PRDX5 ESRRA CATSPERZ ENSG00000207024 KCNK4-TEX40 KCNK4 BAD
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPR137 on UCSC Golden Path with GeneCards custom track

Promoters for GPR137 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for GPR137 Gene

Genomic Locations for GPR137 Gene
20,241 bases
Plus strand

Genomic View for GPR137 Gene

Genes around GPR137 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR137 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR137 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR137 Gene

Proteins for GPR137 Gene

  • Protein details for GPR137 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Integral membrane protein GPR137
    Protein Accession:
    Secondary Accessions:
    • B4DTG7
    • B7Z7M1
    • Q4G0Y9
    • Q8N4K6

    Protein attributes for GPR137 Gene

    417 amino acids
    Molecular mass:
    46059 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GPR137 Gene


neXtProt entry for GPR137 Gene

Post-translational modifications for GPR137 Gene

  • Glycosylation at posLast=44 and posLast=257257
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPR137 Gene

Domains & Families for GPR137 Gene

Gene Families for GPR137 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for GPR137 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GPR137 family.
  • Belongs to the GPR137 family.
genes like me logo Genes that share domains with GPR137: view

Function for GPR137 Gene

Phenotypes From GWAS Catalog for GPR137 Gene

genes like me logo Genes that share phenotypes with GPR137: view

Animal Model Products

CRISPR Products

miRNA for GPR137 Gene

miRTarBase miRNAs that target GPR137

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR137 Gene

Localization for GPR137 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR137 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR137 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPR137 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR137: view

Pathways & Interactions for GPR137 Gene

SuperPathways for GPR137 Gene

No Data Available

Interacting Proteins for GPR137 Gene

Gene Ontology (GO) - Biological Process for GPR137 Gene


No data available for Pathways by source and SIGNOR curated interactions for GPR137 Gene

Drugs & Compounds for GPR137 Gene

No Compound Related Data Available

Transcripts for GPR137 Gene

Unigene Clusters for GPR137 Gene

G protein-coupled receptor 137:
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR137 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b
SP1: - - - - - - - - -
SP2: -
SP3: - -
SP4: - - - - - - - - - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - -
SP9: -
SP11: - - -

Relevant External Links for GPR137 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR137 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR137 Gene

mRNA differential expression in normal tissues according to GTEx for GPR137 Gene

This gene is overexpressed in Testis (x6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR137 Gene

Protein tissue co-expression partners for GPR137 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPR137 Gene:


SOURCE GeneReport for Unigene cluster for GPR137 Gene:


Evidence on tissue expression from TISSUES for GPR137 Gene

  • Pancreas(4.3)
genes like me logo Genes that share expression patterns with GPR137: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR137 Gene

Orthologs for GPR137 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR137 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR137 33 34
  • 99.83 (n)
(Canis familiaris)
Mammalia GPR137 33 34
  • 91.25 (n)
(Bos Taurus)
Mammalia GPR137 33 34
  • 91.05 (n)
(Rattus norvegicus)
Mammalia Gpr137 33
  • 89.39 (n)
(Mus musculus)
Mammalia Gpr137 33 16 34
  • 88.89 (n)
(Monodelphis domestica)
Mammalia GPR137 34
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia GPR137 34
  • 70 (a)
(Anolis carolinensis)
Reptilia GPR137 34
  • 61 (a)
(Danio rerio)
Actinopterygii GPR137 (1 of 2) 34
  • 51 (a)
gpr137 34
  • 46 (a)
Species where no ortholog for GPR137 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR137 Gene

Gene Tree for GPR137 (if available)
Gene Tree for GPR137 (if available)

Paralogs for GPR137 Gene

Paralogs for GPR137 Gene

genes like me logo Genes that share paralogs with GPR137: view

Variants for GPR137 Gene

Sequence variations from dbSNP and Humsavar for GPR137 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000009542 -- 64,272,887(+) GCCCT(C/G)ACTCC intron-variant
rs1000679595 -- 64,276,575(+) AAGTG(C/T)CTCGG intron-variant
rs1000873868 -- 64,270,016(+) AAAAC(A/C)CAAAA upstream-variant-2KB, utr-variant-3-prime
rs1000999174 -- 64,286,294(+) GAGAC(G/T)GCCCT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001012410 -- 64,273,643(+) TGGGA(A/G)GCCGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR137 Gene

Variant ID Type Subtype PubMed ID
nsv951010 CNV deletion 24416366
nsv832186 CNV loss 17160897
nsv469961 CNV loss 18288195
nsv357 CNV insertion 18451855
esv3626658 CNV loss 21293372
dgv1963n54 CNV loss 21841781

Variation tolerance for GPR137 Gene

Residual Variation Intolerance Score: 21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR137 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR137 Gene

Disorders for GPR137 Gene

Relevant External Links for GPR137

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GPR137 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR137 Gene

Publications for GPR137 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Characterization of five novel human genes in the 11q13-q22 region. (PMID: 10873569) O'Brien KP … Dumanski JP (Biochemical and biophysical research communications 2000) 2 3 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Knockdown of GPR137,G Protein-coupled receptor 137, Inhibits the Proliferation and Migration of Human Prostate Cancer Cells. (PMID: 26669804) Ren J … Xu D (Chemical biology & drug design 2016) 3 60

Products for GPR137 Gene

Sources for GPR137 Gene

Loading form....