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Aliases for GPR135 Gene

Aliases for GPR135 Gene

  • G Protein-Coupled Receptor 135 2 3 5
  • Probable G-Protein Coupled Receptor 135 3
  • HUMNPIIY20 3

External Ids for GPR135 Gene

Previous GeneCards Identifiers for GPR135 Gene

  • GC14M057920
  • GC14M059000
  • GC14M059895
  • GC14M040094

Summaries for GPR135 Gene

GeneCards Summary for GPR135 Gene

GPR135 (G Protein-Coupled Receptor 135) is a Protein Coding gene. Among its related pathways are GPCRs, Other. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR63.

UniProtKB/Swiss-Prot for GPR135 Gene

  • Orphan receptor.

Gene Wiki entry for GPR135 Gene

Additional gene information for GPR135 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR135 Gene

Genomics for GPR135 Gene

Regulatory Elements for GPR135 Gene

Enhancers for GPR135 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H059771 1.1 Ensembl ENCODE 11.4 -306.3 -306341 0 INSM2 FEZF1 ZNF366 ZSCAN5C RCOR1 ZNF174 CEBPB TSHZ1 ZNF488 ZEB2 GPR135 GC14M059744 GC14P059777
GH14H058660 0.7 ENCODE 13.4 +805.1 805069 0 ZNF202 ZFP64 ZC3H11A ZNF140 ZBTB8A ZNF781 ZNF518A NR2F2 ZNF697 ZNF555 KIAA0586 PSMA3-AS1 ENSG00000258682 HMGB1P14 L3HYPDH GPR135 TIMM9 DACT1 JKAMP ARID4A
GH14H059437 0.8 Ensembl ENCODE 11.1 +26.4 26413 2 CEBPB FEZF1 NFE2 EP300 L3HYPDH GPR135 DAAM1 PIR32681 GC14P059386
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPR135 on UCSC Golden Path with GeneCards custom track

Promoters for GPR135 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000069182 396 1201 CTCF MXI1 SAP130 BACH1 ARID4B SIN3A BMI1 E2F1 CTBP1 CREM

Genomic Location for GPR135 Gene

59,429,022 bp from pter
59,465,396 bp from pter
36,375 bases
Minus strand

Genomic View for GPR135 Gene

Genes around GPR135 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR135 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR135 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR135 Gene

Proteins for GPR135 Gene

  • Protein details for GPR135 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 135
    Protein Accession:
    Secondary Accessions:
    • Q7Z604
    • Q86SM3
    • Q8NH39

    Protein attributes for GPR135 Gene

    494 amino acids
    Molecular mass:
    51736 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC05800.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for GPR135 Gene

Post-translational modifications for GPR135 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPR135 Gene

No data available for DME Specific Peptides for GPR135 Gene

Domains & Families for GPR135 Gene

Gene Families for GPR135 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR135 Gene

Suggested Antigen Peptide Sequences for GPR135 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR135: view

Function for GPR135 Gene

Molecular function for GPR135 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Gene Ontology (GO) - Molecular Function for GPR135 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GPR135: view
genes like me logo Genes that share phenotypes with GPR135: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR135

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GPR135
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR135 Gene

Localization for GPR135 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR135 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR135 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR135 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR135: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR135 Gene

Pathways & Interactions for GPR135 Gene

SuperPathways for GPR135 Gene

SuperPathway Contained pathways
1 GPCRs, Other
genes like me logo Genes that share pathways with GPR135: view

Pathways by source for GPR135 Gene

1 BioSystems pathway for GPR135 Gene

Interacting Proteins for GPR135 Gene

Gene Ontology (GO) - Biological Process for GPR135 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR135: view

No data available for SIGNOR curated interactions for GPR135 Gene

Drugs & Compounds for GPR135 Gene

No Compound Related Data Available

Transcripts for GPR135 Gene

Unigene Clusters for GPR135 Gene

G protein-coupled receptor 135:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GPR135
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for GPR135 Gene

No ASD Table

Relevant External Links for GPR135 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR135 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR135 Gene

mRNA differential expression in normal tissues according to GTEx for GPR135 Gene

This gene is overexpressed in Testis (x4.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR135 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPR135 Gene:


SOURCE GeneReport for Unigene cluster for GPR135 Gene:

genes like me logo Genes that share expression patterns with GPR135: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR135 Gene

Orthologs for GPR135 Gene

This gene was present in the common ancestor of mammals.

Orthologs for GPR135 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPR135 33 34
  • 88.91 (n)
(Canis familiaris)
Mammalia GPR135 33
  • 87.47 (n)
(Rattus norvegicus)
Mammalia Gpr135 33
  • 83.33 (n)
(Mus musculus)
Mammalia Gpr135 33 16 34
  • 83.04 (n)
(Monodelphis domestica)
Mammalia GPR135 34
  • 55 (a)
Species where no ortholog for GPR135 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GPR135 Gene

Gene Tree for GPR135 (if available)
Gene Tree for GPR135 (if available)

Paralogs for GPR135 Gene

Paralogs for GPR135 Gene

genes like me logo Genes that share paralogs with GPR135: view

Variants for GPR135 Gene

Sequence variations from dbSNP and Humsavar for GPR135 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000134954 -- 59,453,806(+) CTGTA(C/T)CCTTT utr-variant-3-prime
rs1000189315 -- 59,452,504(+) TGTCA(C/T)TAGGA downstream-variant-500B
rs1000234658 -- 59,456,455(+) CCCAC(A/G)ATGTA utr-variant-3-prime
rs1000259062 -- 59,456,239(+) AAACA(A/G)AAGTA utr-variant-3-prime
rs1000463308 -- 59,454,139(+) ACACA(-/C)CCCTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GPR135 Gene

Variant ID Type Subtype PubMed ID
nsv832810 CNV loss 17160897

Variation tolerance for GPR135 Gene

Residual Variation Intolerance Score: 81.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.66; 65.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR135 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR135 Gene

Disorders for GPR135 Gene

Relevant External Links for GPR135

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GPR135 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR135 Gene

Publications for GPR135 Gene

  1. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. (PMID: 14623098) Fredriksson R … Schiöth HB (FEBS letters 2003) 2 3 4 60
  2. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 45 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis DK … Gaitanaris GA (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 60
  5. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland SL … Hayden MR (Human molecular genetics 2014) 3 60

Products for GPR135 Gene

Sources for GPR135 Gene

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