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Aliases for GPR135 Gene

Aliases for GPR135 Gene

  • G Protein-Coupled Receptor 135 2 3 5
  • Probable G-Protein Coupled Receptor 135 3
  • HUMNPIIY20 3

External Ids for GPR135 Gene

Previous GeneCards Identifiers for GPR135 Gene

  • GC14M057920
  • GC14M059000
  • GC14M059895
  • GC14M040094

Summaries for GPR135 Gene

GeneCards Summary for GPR135 Gene

GPR135 (G Protein-Coupled Receptor 135) is a Protein Coding gene. Among its related pathways are GPCRs, Other. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR45.

UniProtKB/Swiss-Prot for GPR135 Gene

  • Orphan receptor.

Gene Wiki entry for GPR135 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR135 Gene

Genomics for GPR135 Gene

Regulatory Elements for GPR135 Gene

Enhancers for GPR135 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F059437 0.8 Ensembl ENCODE 11.1 +26.4 26405 2.4 CEBPB NFE2 FEZF1 EP300 L3HYPDH GPR135 DAAM1 PIR32681 GC14P059386
GH14F059175 0.8 ENCODE 10.4 +289.8 289759 0.1 MXI1 TBL1XR1 WRNIP1 BMI1 RELA CBX5 EED ZNF143 ETV6 CREM GPR135 PPIAP5 AKR1B1P5
GH14F059127 0.6 ENCODE 11 +338.1 338059 0.2 CTCF ZNF654 TRIM22 REST RAD21 NR2F2 GATA3 SMC3 DAAM1 GPR135 DACT1 GC14M059001 GC14M059136
GH14F059177 0.5 ENCODE 10.4 +287.9 287879 0.2 JUND ZFP64 TEAD4 ZBTB20 GPR135 L3HYPDH PPIAP5 AKR1B1P5
GH14F059332 1.2 FANTOM5 Ensembl ENCODE 2.3 +131.8 131814 2.4 RFX1 RFX3 ATF3 JUN CEBPB FOS RAD21 DAAM1 L3HYPDH RTN1 GPR135 GC14P059386 GC14P059252
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPR135 on UCSC Golden Path with GeneCards custom track

Promoters for GPR135 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000180462 396 1600 CTCF SAP130 ARID4B SIN3A RFX5 E2F1 CTBP1 POLR2A EGR1 CREM

Genomic Location for GPR135 Gene

Chromosome:
14
Start:
59,429,022 bp from pter
End:
59,465,396 bp from pter
Size:
36,375 bases
Orientation:
Minus strand

Genomic View for GPR135 Gene

Genes around GPR135 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR135 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR135 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR135 Gene

Proteins for GPR135 Gene

  • Protein details for GPR135 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZ08-GP135_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 135
    Protein Accession:
    Q8IZ08
    Secondary Accessions:
    • Q7Z604
    • Q86SM3
    • Q8NH39

    Protein attributes for GPR135 Gene

    Size:
    494 amino acids
    Molecular mass:
    51736 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05800.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for GPR135 Gene

Post-translational modifications for GPR135 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPR135 Gene

No data available for DME Specific Peptides for GPR135 Gene

Domains & Families for GPR135 Gene

Gene Families for GPR135 Gene

Protein Domains for GPR135 Gene

Suggested Antigen Peptide Sequences for GPR135 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZ08

UniProtKB/Swiss-Prot:

GP135_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR135: view

Function for GPR135 Gene

Molecular function for GPR135 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Gene Ontology (GO) - Molecular Function for GPR135 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GPR135: view
genes like me logo Genes that share phenotypes with GPR135: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR135

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR135 Gene

Localization for GPR135 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR135 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR135 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR135 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR135: view

Pathways & Interactions for GPR135 Gene

SuperPathways for GPR135 Gene

SuperPathway Contained pathways
1 GPCRs, Other
genes like me logo Genes that share pathways with GPR135: view

Pathways by source for GPR135 Gene

1 BioSystems pathway for GPR135 Gene

Interacting Proteins for GPR135 Gene

Gene Ontology (GO) - Biological Process for GPR135 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR135: view

No data available for SIGNOR curated interactions for GPR135 Gene

Transcripts for GPR135 Gene

Unigene Clusters for GPR135 Gene

G protein-coupled receptor 135:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR135 Gene

No ASD Table

Relevant External Links for GPR135 Gene

GeneLoc Exon Structure for
GPR135
ECgene alternative splicing isoforms for
GPR135

Expression for GPR135 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR135 Gene

mRNA differential expression in normal tissues according to GTEx for GPR135 Gene

This gene is overexpressed in Testis (x4.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR135 Gene



NURSA nuclear receptor signaling pathways regulating expression of GPR135 Gene:

GPR135

SOURCE GeneReport for Unigene cluster for GPR135 Gene:

Hs.647573
genes like me logo Genes that share expression patterns with GPR135: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for GPR135 Gene

Orthologs for GPR135 Gene

This gene was present in the common ancestor of mammals.

Orthologs for GPR135 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPR135 34 35
  • 88.91 (n)
dog
(Canis familiaris)
Mammalia GPR135 34
  • 87.47 (n)
rat
(Rattus norvegicus)
Mammalia Gpr135 34
  • 83.33 (n)
mouse
(Mus musculus)
Mammalia Gpr135 34 16 35
  • 83.04 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR135 35
  • 55 (a)
OneToOne
Species where no ortholog for GPR135 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GPR135 Gene

ENSEMBL:
Gene Tree for GPR135 (if available)
TreeFam:
Gene Tree for GPR135 (if available)

Paralogs for GPR135 Gene

Paralogs for GPR135 Gene

genes like me logo Genes that share paralogs with GPR135: view

Variants for GPR135 Gene

Sequence variations from dbSNP and Humsavar for GPR135 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10136708 -- 59,460,658(+) TGAGC(G/T)AATGC intron-variant
rs10137821 -- 59,457,864(+) ggttc(A/G)tattt intron-variant
rs10144896 -- 59,460,172(+) CTATG(G/T)AGTCT intron-variant
rs10147325 -- 59,453,347(+) atggg(A/T)aatct utr-variant-3-prime
rs10151143 -- 59,454,829(+) GGGTG(C/T)GGTGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GPR135 Gene

Variant ID Type Subtype PubMed ID
nsv832810 CNV loss 17160897

Variation tolerance for GPR135 Gene

Residual Variation Intolerance Score: 81.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.66; 65.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR135 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR135

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR135 Gene

Disorders for GPR135 Gene

Relevant External Links for GPR135

Genetic Association Database (GAD)
GPR135
Human Genome Epidemiology (HuGE) Navigator
GPR135
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR135

No disorders were found for GPR135 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR135 Gene

Publications for GPR135 Gene

  1. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. (PMID: 14623098) Fredriksson R. … Schioeth H.B. (FEBS Lett. 2003) 2 3 4 64
  2. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2010) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis D.K. … Gaitanaris G.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 64
  5. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3 64

Products for GPR135 Gene

Sources for GPR135 Gene

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