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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GPR133 Gene

protein-coding   GIFtS: 52
GCID: GC12P131438

G Protein-Coupled Receptor 133

  Search for GPR133
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
G Protein-Coupled Receptor 1331 2
PGR252 3 5
G-Protein Coupled Receptor PGR252 3
Probable G-Protein Coupled Receptor 1332

External Ids:    HGNC: 198931   Entrez Gene: 2833832   Ensembl: ENSG000001114527   OMIM: 6136395   UniProtKB: Q6QNK23   

Export aliases for GPR133 gene to outside databases

Previous GC identifers: GC12P129821 GC12P129840 GC12P129963 GC12P128420


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GPR133 Gene:
The adhesion G-protein-coupled receptors (GPCRs), including GPR133, are membrane-bound proteins with long N
termini containing multiple domains. GPCRs, or GPRs, contain 7 transmembrane domains and transduce extracellular
signals through heterotrimeric G proteins (summary by Bjarnadottir et al., 2004 (PubMed 15203201)).(supplied by
OMIM, Nov 2010)

GeneCards Summary for GPR133 Gene: 
GPR133 (G protein-coupled receptor 133) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR97.

UniProtKB/Swiss-Prot: GP133_HUMAN, Q6QNK2
Function: Orphan receptor

Gene Wiki entry for GPR133 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009755.19  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GPR133 gene promoter:
         Nkx3-1   LHX3b/Lhx3b   Nkx3-1 v4   p53   Nkx3-1 v1   AREB6   Nkx3-1 v2   Nkx3-1 v3   LHX3a/Lhx3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPR133 promoter sequence
   Search SABiosciences Chromatin IP Primers for GPR133

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPR133


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.33   Ensembl cytogenetic band:  12q24.33   HGNC cytogenetic band: 12q24.33

GPR133 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPR133 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P131438:  view genomic region     (about GC identifiers)

Start:
131,438,452 bp from pter      End:
131,626,014 bp from pter
Size:
187,563 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GP133_HUMAN, Q6QNK2 (See protein sequence)
Recommended Name: Probable G-protein coupled receptor 133 precursor  
Size: 874 amino acids; 96530 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q2M1L3 Q6ZMQ1 Q7Z7M2 Q86SM4
Alternative splicing: 3 isoforms:  Q6QNK2-1   Q6QNK2-2   Q6QNK2-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GPR133: NX_Q6QNK2

Explore proteomics data for GPR133 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6QNK2

  • GPR133 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GPR133 Protein Expression
    REFSEQ proteins: NP_942122.2  
    ENSEMBL proteins: 
     ENSP00000261654   ENSP00000437672   ENSP00000442501   ENSP00000444425   ENSP00000444836  
     ENSP00000443158   ENSP00000446272   ENSP00000365872   ENSP00000334127   ENSP00000438021  

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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GPR133 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    GPR133 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    GPCRBO: GPCR / Class B : Orphans

    IUPHAR Guide to PHARMACOLOGY protein family classification: GPR133 
    Adhesion Class GPCRs

    5/6 InterPro protein domains (see all 6):
     IPR013320 ConA-like_subgrp
     IPR000832 GPCR_2_secretin-like
     IPR017983 GPCR_2_secretin-like_CS
     IPR017981 GPCR_2-like
     IPR008985 ConA-like_lec_gl_sf

    Graphical View of Domain Structure for InterPro Entry Q6QNK2

    ProtoNet protein and cluster: Q6QNK2

    2 Blocks protein domains:
    IPB000203 GPS domain
    IPB000832 G-protein coupled receptors family 2 (secretin-like)


    UniProtKB/Swiss-Prot: GP133_HUMAN, Q6QNK2
    Similarity: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily
    Similarity: Contains 1 GPS domain


    GPR133 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GP133_HUMAN, Q6QNK2
    Function: Orphan receptor

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity ----
    GO:0004930G-protein coupled receptor activity IEA--
         
    GPR133 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Gpr133 (no phenotypes)

    GPR133 for phenotypes           About GeneDecksing

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GPR133 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1GPCRs, Other
    GPCRs, Other


    1 BioSystems Pathway for GPR133
        GPCRs, Other



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GPR133

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway ----
    GO:0007186G-protein coupled receptor signaling pathway TAS15203201
    GO:0007218neuropeptide signaling pathway IEA--

    GPR133 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GPR133 (GP133)

    Search CenterWatch for drugs/clinical trials and news about GPR133 / GP133

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GPR133 gene: 
    NM_198827.3  

    Unigene Cluster for GPR133:

    G protein-coupled receptor 133
    Hs.719239  [show with all ESTs]
    Unigene Representative Sequence: NM_198827
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000541143 ENST00000261654(uc001uit.4 uc010tbm.2) ENST00000543826
    ENST00000542091 ENST00000535015 ENST00000541937 ENST00000537600 ENST00000544673
    ENST00000545900 ENST00000376682 ENST00000446583(uc009zyp.3) ENST00000335486(uc009zyo.3)
    ENST00000543617(uc001uiv.1) ENST00000536988 ENST00000537489 ENST00000540207

    miRNA
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    hsa-miR-142-5p hsa-miR-4328 hsa-miR-106a hsa-miR-128 hsa-miR-548s hsa-miR-519a hsa-miR-298 hsa-miR-93
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    Additional mRNA sequence: 

    AK090662.1 AK131538.1 AL162032.1 AY255587.1 AY278561.1 AY532280.1 BC047951.1 BC112307.1 
    BC112309.1 BC143775.1 EU523118.1 

    10 DOTS entries:

    DT.95150812  DT.91671759  DT.75197238  DT.91835389  DT.97802542  DT.40196994  DT.91939242  DT.121211530 
    DT.40109966  DT.92047385 

    24/42 AceView cDNA sequences (see all 42):

    AK131538 AW298159 AY255587 BG185107 AW513660 AI420573 CA412088 BC047951 
    AL162032 BF434396 BQ028954 AI364031 BX100891 BG196985 BG009204 AY278561 
    AL699795 BX649116 CB265958 BX489970 NM_198827 BG009205 AY532280 AW298629 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GPR133 expression in normal human tissues (normalized intensities)      GPR133 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCTGAAAAA
    GPR133 Expression
    About this image


    GPR133 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Thymus (Hematopoietic System)
             Thymus
     
     Adipose (Muscoskeletal System)
             Visceral White Adipose
     
     Liver (Hepatobiliary System)
             Mature Mesothelial Cells Hepatic Mesenchyme

    See GPR133 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GPR133

    SOURCE GeneReport for Unigene cluster: Hs.719239
        SABiosciences Expression via Pathway-Focused PCR Array including GPR133: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR133

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for GPR133 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpr1331 , 5 G protein-coupled receptor 1331, 5 78.95(n)1
    80.83(a)1
      5 (67.99 cM)5
    2432771  NM_001081342.11  NP_001074811.11 
     1290967505 
    chicken
    (Gallus gallus)
    Aves GPR1331 G protein-coupled receptor 133 68.38(n)
    69.3(a)
      416803  XM_415094.3  XP_415094.3 
    zebrafish
    (Danio rerio)
    Actinopterygii gpr1331 G protein-coupled receptor 133 63.31(n)
    59.83(a)
      791731  XM_003199130.1  XP_003199178.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cirl6
    Cirl
    8(a)
    1 → many
    2R(4502227-4512708)
    worm
    (Caenorhabditis elegans)
    Secernentea lat-16
    Protein LAT-1, isoform b
    12(a)
    1 → many
    II(8896841-8908653)


    ENSEMBL Gene Tree for GPR133 (if available)
    TreeFam Gene Tree for GPR133 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GPR133 gene
    GPR972  CD972  ELTD12  LPHN22  LPHN12  GPR1142  EMR12  LPHN32  
    EMR22  GPR1122  GPR1442  GPR562  EMR32  GPR1262  GPR642  
    5 SIMAP similar genes for GPR133 using alignment to 9 protein entries:     GP133_HUMAN (see all proteins):
    ELTD1    DKFZp434B1272    FLJ00015    EMR4P    FLJ00046

    GPR133 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for GPR133
    PGOHUM00000258648


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4738 SNPs in GPR133 are shown (see all 4738)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1480179571,2
    Cuntested1131476851(+) GTCCCG/AGAGTG 2 /R /G mis11Minor allele frequency- A:0.00NA 4552
    rs341066041,2
    C--128502535(+) ATGGG-/GT/T  
            
    GTTAG
    1 -- int11CSA 2
    rs1866073871,2
    --131436531(+) ATAAAC/TGTCTA 1 -- us2k10--------
    rs1932821461,2
    --131436680(+) TCAGAA/GACATC 1 -- us2k10--------
    rs753869881,2
    C,F--131436714(+) TGGACC/TACTCA 1 -- us2k12Minor allele frequency- T:0.02NA 122
    rs108482571,2
    C,F,A,H--131436746(+) GGCTTC/TAGGAC 1 -- us2k115Minor allele frequency- T:0.15NS EA NA WA CSA 793
    rs1406329311,2
    --131436754(+) GACACC/GCTGCT 1 -- us2k10--------
    rs757431271,2
    C,F--131436771(+) GGAGGC/TGGGCT 1 -- us2k11Minor allele frequency- T:0.10WA 118
    rs1119526571,2
    C,F--131436773(+) AGGCGG/AGCTCT 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs765429211,2
    C,F--131436819(+) GCAGGC/GAAATA 1 -- us2k12Minor allele frequency- G:0.12NA 122

    HapMap Linkage Disequilibrium report for GPR133 (131438452 - 131626014 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/54 variations for GPR133 (see all 54):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2746817CNV Deletion23290073
    esv2746820CNV Deletion23290073
    esv2746810CNV Deletion23290073
    dgv9e196CNV Deletion17116639
    esv2746806CNV Deletion23290073
    esv2676329CNV Deletion23128226
    esv2672456CNV Deletion23128226
    esv2746803CNV Deletion23290073
    esv2746813CNV Deletion23290073
    esv2746822CNV Deletion23290073

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    GPR133 for disorders           About MalaCards
    OMIM gene information: 613639    OMIM disorders: --


    GPR133 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GPR133
    Human Genome Epidemiology (HuGE) Navigator: GPR133 (3 documents)

    Export disorders for GPR133 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GPR133 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with GPR133)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. Joint influence of small-effect genetic variants on h uman longevity. (PubMed id 20834067)1, 4 Yashin A.I....Ukraintseva S.V. (2010)
    3. A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project. (PubMed id 20031603)1, 4 Marroni F....Pramstaller P.P. (2009)
    4. Genetic variation in GPR133 is associated with height : genome wide association study in the self-contained population of Sorbs. (PubMed id 19729412)1, 4 TAPnjes A....Stumvoll M. (2009)
    5. A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PubMed id 18464913)1, 4 Melzer D....Ferrucci L. (2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The human and mouse repertoire of the adhesion family of G-protein- coupled receptors. (PubMed id 15203201)1, 2 Bjarnadottir T.K.... Schioeth H.B. (2004)
    9. The G protein-coupled receptor repertoires of human and mouse. (PubMed id 12679517)1, 2 Vassilatis D.K.... Gaitanaris G.A. (2003)
    10. Cell adhesion receptor GPR133 couples to Gs protein. (PubMed id 22025619)1 Bohnekamp J. and Schoneberg T. (2011)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 283383 HGNC: 19893 AceView: GPR133 Ensembl:ENSG00000111452 euGenes: HUgn283383
    ECgene: GPR133 H-InvDB: GPR133

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GPR133 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GPR133 gene:
    Search GeneIP for patents involving GPR133

    GeneCards and IP:
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