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Aliases for GPR132 Gene

Aliases for GPR132 Gene

  • G Protein-Coupled Receptor 132 2 3
  • G2 Accumulation Protein 3 4
  • G2A 3 4
  • G2 Accumulation 2

External Ids for GPR132 Gene

Previous GeneCards Identifiers for GPR132 Gene

  • GC14M103489
  • GC14M103490
  • GC14M104586
  • GC14M105558
  • GC14M105560
  • GC14M085709
  • GC14M105563
  • GC14M105568
  • GC14M105573
  • GC14M105578
  • GC14M105593
  • GC14M105600
  • GC14M105608

Summaries for GPR132 Gene

Entrez Gene Summary for GPR132 Gene

  • This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein was reported to be a receptor for lysophosphatidylcholine action, but PubMedID: 15653487 retracts this finding and instead suggests this protein to be an effector of lysophosphatidylcholine action. This protein may have proton-sensing activity and may be a receptor for oxidized free fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for GPR132 Gene

GPR132 (G Protein-Coupled Receptor 132) is a Protein Coding gene. Diseases associated with GPR132 include inclusion conjunctivitis. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is P2RY8.

UniProtKB/Swiss-Prot for GPR132 Gene

  • May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9-hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton-sensing activity.

Gene Wiki entry for GPR132 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR132 Gene

Genomics for GPR132 Gene

Regulatory Elements for GPR132 Gene

Genomic Location for GPR132 Gene

Chromosome:
14
Start:
105,049,389 bp from pter
End:
105,065,550 bp from pter
Size:
16,162 bases
Orientation:
Minus strand

Genomic View for GPR132 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPR132 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR132 Gene

Proteins for GPR132 Gene

  • Protein details for GPR132 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNW8-GP132_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 132
    Protein Accession:
    Q9UNW8
    Secondary Accessions:
    • A8K7X7
    • B4E144
    • Q9BSU2

    Protein attributes for GPR132 Gene

    Size:
    380 amino acids
    Molecular mass:
    42499 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GPR132 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPR132 Gene

Proteomics data for GPR132 Gene at MOPED

Post-translational modifications for GPR132 Gene

  • Glycosylation at Asn 35
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR132 Gene

Antibody Products

No data available for DME Specific Peptides for GPR132 Gene

Domains & Families for GPR132 Gene

Gene Families for GPR132 Gene

Protein Domains for GPR132 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UNW8

UniProtKB/Swiss-Prot:

GP132_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR132: view

Function for GPR132 Gene

Molecular function for GPR132 Gene

UniProtKB/Swiss-Prot Function:
May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9-hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton-sensing activity.
UniProtKB/Swiss-Prot Induction:
By stress and DNA-damaging agents.

Gene Ontology (GO) - Molecular Function for GPR132 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
genes like me logo Genes that share ontologies with GPR132: view
genes like me logo Genes that share phenotypes with GPR132: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPR132

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR132 Gene

Localization for GPR132 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR132 Gene

Cell membrane; Multi-pass membrane protein. Note=Internalized and accumulated in endosomal compartments. LPC triggers the relocalization from the endosomal compartment to the cell surface (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR132 Gene COMPARTMENTS Subcellular localization image for GPR132 gene
Compartment Confidence
plasma membrane 4
cytosol 3
nucleus 3
cytoskeleton 2
extracellular 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GPR132 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with GPR132: view

Pathways & Interactions for GPR132 Gene

genes like me logo Genes that share pathways with GPR132: view

Pathways by source for GPR132 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for GPR132 Gene

Gene Ontology (GO) - Biological Process for GPR132 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IEA --
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IBA --
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle IEA --
genes like me logo Genes that share ontologies with GPR132: view

No data available for SIGNOR curated interactions for GPR132 Gene

Drugs & Compounds for GPR132 Gene

(1) Drugs for GPR132 Gene - From: IUPHAR and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
9-hydroxyoctadecadienoic acid Pharma Full agonist, Agonist 0
genes like me logo Genes that share compounds with GPR132: view

Transcripts for GPR132 Gene

mRNA/cDNA for GPR132 Gene

(4) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR132 Gene

G protein-coupled receptor 132:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPR132

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR132 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: -
SP2:
SP3: - - - - - -
SP4: - -
SP5:
SP6: -
SP7: - - - - - - -

Relevant External Links for GPR132 Gene

GeneLoc Exon Structure for
GPR132
ECgene alternative splicing isoforms for
GPR132

Expression for GPR132 Gene

mRNA expression in normal human tissues for GPR132 Gene

mRNA differential expression in normal tissues according to GTEx for GPR132 Gene

This gene is overexpressed in Whole Blood (x15.7).

Protein differential expression in normal tissues from HIPED for GPR132 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR132 Gene



SOURCE GeneReport for Unigene cluster for GPR132 Gene Hs.532504

mRNA Expression by UniProt/SwissProt for GPR132 Gene

Q9UNW8-GP132_HUMAN
Tissue specificity: Highly expressed in macrophages and hematopoietic tissues rich in lymphocytes, like spleen and thymus. Weakly expressed in heart and lung. In atherosclerotic plaques, expression is observed around the lipid core and at the shoulder region.
genes like me logo Genes that share expression patterns with GPR132: view

Protein tissue co-expression partners for GPR132 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GPR132 Gene

Orthologs for GPR132 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR132 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPR132 35
  • 78.88 (n)
  • 67.61 (a)
GPR132 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPR132 35
  • 79.15 (n)
  • 72.11 (a)
GPR132 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr132 35
  • 76.07 (n)
  • 70.41 (a)
Gpr132 16
Gpr132 36
  • 68 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPR132 35
  • 98.16 (n)
  • 96.26 (a)
GPR132 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr132 35
  • 75.85 (n)
  • 71.87 (a)
oppossum
(Monodelphis domestica)
Mammalia GPR132 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR132 36
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR132 35
  • 55.87 (n)
  • 47.94 (a)
GPR132 36
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR132 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr132 35
  • 55.13 (n)
  • 48.89 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC797380 35
  • 52.38 (n)
  • 46.18 (a)
GPR132 (1 of 3) 36
  • 44 (a)
OneToMany
GPR132 (2 of 3) 36
  • 38 (a)
OneToMany
GPR132 (3 of 3) 36
  • 30 (a)
OneToMany
Species with no ortholog for GPR132:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR132 Gene

ENSEMBL:
Gene Tree for GPR132 (if available)
TreeFam:
Gene Tree for GPR132 (if available)

Paralogs for GPR132 Gene

Paralogs for GPR132 Gene

(5) SIMAP similar genes for GPR132 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with GPR132: view

Variants for GPR132 Gene

Sequence variations from dbSNP and Humsavar for GPR132 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs3803321 -- 105,052,119(-) CACTC(G/T)TGTCT intron-variant
rs3803322 -- 105,051,999(-) CTGGT(A/C/T)GTGGT synonymous-codon, reference, utr-variant-5-prime
rs3803323 -- 105,051,306(-) AGGAA(C/T)GCCAT reference, synonymous-codon
rs3809464 -- 105,067,362(-) CACAG(C/G)CCGGG upstream-variant-2KB
rs3809465 -- 105,067,350(-) CAGCC(A/T)CCACT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GPR132 Gene

Variant ID Type Subtype PubMed ID
nsv902421 CNV Loss 21882294
dgv2020n71 CNV Loss 21882294
nsv456458 CNV Loss 19166990
nsv902424 CNV Loss 21882294
nsv902425 CNV Loss 21882294
nsv9175 CNV Gain 18304495
nsv902426 CNV Gain 21882294
nsv902427 CNV Loss 21882294
dgv659e1 CNV Complex 17122850
esv2665589 CNV Deletion 23128226

Variation tolerance for GPR132 Gene

Residual Variation Intolerance Score: 33.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR132 Gene

HapMap Linkage Disequilibrium report
GPR132

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR132 Gene

Disorders for GPR132 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPR132 Gene - From: DISEASES

Disorder Aliases PubMed IDs
inclusion conjunctivitis
  • inclusion blenorrhea
- elite association

Relevant External Links for GPR132

Genetic Association Database (GAD)
GPR132
Human Genome Epidemiology (HuGE) Navigator
GPR132
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR132
genes like me logo Genes that share disorders with GPR132: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR132 Gene

Publications for GPR132 Gene

  1. G protein-coupled receptor G2A: friend or foe of the vasculature? (PMID: 17332435) Irani K. (Circ. Res. 2007) 23 67
  2. Lysophospholipids of different classes mobilize neutrophil secretory vesicles and induce redundant signaling through G2A. (PMID: 17475884) Frasch S.C. … Bratton D.L. (J. Immunol. 2007) 23 67
  3. Identification of 9-hydroxyoctadecadienoic acid and other oxidized free fatty acids as ligands of the G protein-coupled receptor G2A. (PMID: 16236715) Obinata H. … Izumi T. (J. Biol. Chem. 2005) 23 67
  4. Positron emission tomography imaging analysis of G2A as a negative modifier of lymphoid leukemogenesis initiated by the BCR-ABL oncogene. (PMID: 12086852) Le L.Q. … Witte O.N. (Cancer Cell 2002) 2 67
  5. Therapeutic options for transfusion related acute lung injury; the potential of the G2A receptor. (PMID: 22621271) Ellison M.A. … Silliman C.C. (Curr. Pharm. Des. 2012) 67

Products for GPR132 Gene

Sources for GPR132 Gene

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