Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



GPR132 Gene

protein-coding   GIFtS: 56
GCID: GC14M105608

G Protein-Coupled Receptor 132

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
G Protein-Coupled Receptor 1321 2
G2A2 3 5
G2 Accumulation Protein2 3
G2 Accumulation1
Probable G-Protein Coupled Receptor 1322

External Ids:    HGNC: 174821   Entrez Gene: 299332   Ensembl: ENSG000001834847   OMIM: 6061675   UniProtKB: Q9UNW83   

Export aliases for GPR132 gene to outside databases

Previous GC identifers: GC14M103489 GC14M103490 GC14M104586 GC14M105558 GC14M105560 GC14M085709 GC14M105563 GC14M105568 GC14M105573 GC14M105578 GC14M105593 GC14M105600


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for GPR132 Gene:
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR)
superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate
intracellular signal transduction pathways. This protein was reported to be a receptor for
lysophosphatidylcholine action, but PubMedID: 15653487 retracts this finding and instead suggests this protein to
be an effector of lysophosphatidylcholine action. This protein may have proton-sensing activity and may be a
receptor for oxidized free fatty acids. Alternative splicing results in multiple transcript variants. (provided
by RefSeq, Jul 2013)

GeneCards Summary for GPR132 Gene:
GPR132 (G protein-coupled receptor 132) is a protein-coding gene. Diseases associated with GPR132 include leishmaniasis, and tonsillitis. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is FFAR3.

UniProtKB/Swiss-Prot: GP132_HUMAN, Q9UNW8
Function: Receptor for an unknown ligand. Activates a G alpha protein, most likely G alpha(q). May be involved in
apoptosis. Functions at the G2/M checkpoint to delay mitosis. May serve as a mechanism for T- and B-cells, and
other cell types, to slow their proliferation and repair damaged DNA to ensure proper replication

Gene Wiki entry for GPR132 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000014.9  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the GPR132 gene promoter:
         AREB6   ER-alpha   AML1a   p53   Zic1   STAT5A   Zic3   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPR132 promoter sequence
   Search Chromatin IP Primers for GPR132

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GPR132


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.3   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.3

GPR132 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPR132 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M105608:  view genomic region     (about GC identifiers)

Start:
105,515,728 bp from pter      End:
105,531,782 bp from pter
Size:
16,055 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: GP132_HUMAN, Q9UNW8 (See protein sequence)
Recommended Name: Probable G-protein coupled receptor 132  
Size: 380 amino acids; 42499 Da
Caution: Was originally (PubMed:11474113) thought to be a receptor for lysophosphatidylcholine (LPC) and
sphingosylphosphorylcholine (SPC), However, this work has been retracted
Secondary accessions: Q9BSU2
Alternative splicing: 2 isoforms:  Q9UNW8-1   Q9UNW8-2   

Explore the universe of human proteins at neXtProt for GPR132: NX_Q9UNW8

Explore proteomics data for GPR132 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn35
  • Modification sites at PhosphoSitePlus

  • See GPR132 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001265623.1  NP_001265624.1  NP_001265625.1  NP_037477.1  

    ENSEMBL proteins: 
     ENSP00000328818   ENSP00000376364   ENSP00000448513   ENSP00000438094   ENSP00000448776  
    Reactome Protein details: Q9UNW8

    GPR132 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for GPR132
    GenScript Custom Purified and Recombinant Proteins Services for GPR132
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GPR132

    GPR132 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of GPR132
    Browse R&D Systems for Antibodies
    OriGene Antibodies for GPR132
    OriGene Custom Antibody Services for GPR132
    Novus Biologicals GPR132 Antibodies
    Abcam antibodies for GPR132
    Cloud-Clone Corp. Antibodies for GPR132
    ThermoFisher Antibodies for GPR132
    LSBio Antibodies in human, mouse, rat for GPR132

    GPR132 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GPR132
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GPR132
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GPR132
    Cloud-Clone Corp. CLIAs for GPR132


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    GPCRAO: GPCR / Class A : Orphans

    IUPHAR Guide to PHARMACOLOGY protein family classification: GPR132
    Class A Orphans

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn
     IPR005388 G2A_lysphc_rcpt

    Graphical View of Domain Structure for InterPro Entry Q9UNW8

    ProtoNet protein and cluster: Q9UNW8

    1 Blocks protein domain: IPB005388 G2A lysophosphatidylcholine receptor signature

    UniProtKB/Swiss-Prot: GP132_HUMAN, Q9UNW8
    Similarity: Belongs to the G-protein coupled receptor 1 family


    GPR132 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GP132_HUMAN, Q9UNW8
    Function: Receptor for an unknown ligand. Activates a G alpha protein, most likely G alpha(q). May be involved in
    apoptosis. Functions at the G2/M checkpoint to delay mitosis. May serve as a mechanism for T- and B-cells, and
    other cell types, to slow their proliferation and repair damaged DNA to ensure proper replication
    Induction: By stress and DNA-damaging agents

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
         
    GPR132 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Gpr132):
     cardiovascular system  cellular  growth/size/body  hematopoietic system  immune system 
     liver/biliary system  renal/urinary system  respiratory system 

    GPR132 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GPR132
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GPR132

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GPR132
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GPR132

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat GPR132 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GPR132 (see all 9):
    hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g hsa-let-7b hsa-let-7f
    SwitchGear 3'UTR luciferase reporter plasmidGPR132 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GPR132
    Predesigned siRNA for gene silencing in human, mouse, rat GPR132

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GPR132

    Clone
    Products:
         
    OriGene clones in human, mouse for GPR132 (see all 8)
    OriGene ORF clones in mouse, rat for GPR132
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GPR132 (NM_013345)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GPR132
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPR132

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GPR132
    Browse ESI BIO Cell Lines and PureStem Progenitors for GPR132 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR132


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    GP132_HUMAN, Q9UNW8: Cell membrane; Multi-pass membrane protein (Probable). Note=Internalized and accumulated in
    endosomal compartments. LPC triggers the relocalization from the endosomal compartment to the cell surface (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton3
    cytosol3
    nucleus3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    GPR132 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for GPR132 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    3Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCR ligand binding0.71
    4GPCRs, Other
    GPCRs, Other

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for GPR132
        GPCRs, Other

    2 Reactome Pathways for GPR132
        G alpha (q) signalling events
    Class A/1 (Rhodopsin-like receptors)



    GPR132 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GPR132: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Cell Cycle in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for GPR132

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GPR132 (ENSP000003288184) via UniProtKB, MINT, STRING, and/or I2D (see all 123)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADRA1BENSP000003066624STRING: ENSP00000306662
    CHRM1ENSP000003064904STRING: ENSP00000306490
    CIDEBENSP000003377314STRING: ENSP00000337731
    GPR4ENSP000003197444STRING: ENSP00000319744
    GPR65ENSP000002675494STRING: ENSP00000267549
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle IEA--
    GO:0006950response to stress IEA--
    GO:0007186G-protein coupled receptor signaling pathway ----

    GPR132 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GPR132 (GP132)

    1 IUPHAR Ligand for GPR132 (GPR132)    About this table
    LigandTypeActionAffinityPubmed IDs
    9-hydroxyoctadecadienoic acid
    AgonistFull agonist5.716236715



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for GPR132 gene (4 alternative transcripts): 
    NM_001278694.1  NM_001278695.1  NM_001278696.1  NM_013345.3  

    Unigene Cluster for GPR132:

    G protein-coupled receptor 132
    Hs.532504  [show with all ESTs]
    Unigene Representative Sequence: AB465599
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000329797(uc001yqc.3 uc001yqd.3) ENST00000392585(uc001yqe.3)
    ENST00000551869 ENST00000539291(uc010axe.1) ENST00000546679 ENST00000549990

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GPR132 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GPR132 (see all 9):
    hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g hsa-let-7b hsa-let-7f
    SwitchGear 3'UTR luciferase reporter plasmidGPR132 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GPR132
    Predesigned siRNA for gene silencing in human, mouse, rat GPR132
    Clone
    Products:
         
    OriGene clones in human, mouse for GPR132 (see all 8)
    OriGene ORF clones in mouse, rat for GPR132
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GPR132 (NM_013345)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GPR132
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPR132
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GPR132
    OriGene qSTAR qPCR primer pairs in human, mouse for GPR132
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GPR132
      QuantiTect SYBR Green Assays in human, mouse, rat GPR132
      QuantiFast Probe-based Assays in human, mouse, rat GPR132

    Additional mRNA sequence: 

    AB465599.1 AB465600.1 AF083955.1 AK292142.1 AK303654.1 BC004555.1 BC068024.1 BC084546.1 
    BT007257.1 EU432121.1 EU543705.1 

    4 DOTS entries:

    DT.91703216  DT.91703218  DT.40305184  DT.95135280 

    8 AceView cDNA sequences:

    AX775841 NM_013345 BC004555 AX775937 AX775935 AX775939 AF083955 BT007257 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GPR132 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c
    SP1:                    -                                                   
    SP2:                                                                        
    SP3:              -     -           -     -     -     -                     
    SP4:              -     -                                                   
    SP5:                                                                        


    ECgene alternative splicing isoforms for GPR132

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    GPR132 expression in normal human tissues (normalized intensities)      GPR132 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GPR132 Expression
    About this image


    GPR132 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    GPR132 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GPR132 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.532504

    UniProtKB/Swiss-Prot: GP132_HUMAN, Q9UNW8
    Tissue specificity: Highly expressed in macrophages and hematopoietic tissues rich in lymphocytes, like spleen and
    thymus. Weakly expressed in heart and lung. In atherosclerotic plaques, expression is observed around the lipid
    core and at the shoulder region

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GPR132: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Cell Cycle in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GPR132
    OriGene qSTAR qPCR primer pairs in human, mouse for GPR132
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GPR132
    QuantiTect SYBR Green Assays in human, mouse, rat GPR132
    QuantiFast Probe-based Assays in human, mouse, rat GPR132
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR132

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for GPR132 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpr1321 , 5 G protein-coupled receptor 1321, 5 76.07(n)1
    70.41(a)1
      12 (61.25 cM)5
    566961  NM_019925.41  NP_064309.11 
     1128508765 
    chicken
    (Gallus gallus)
    Aves GPR1321 G protein-coupled receptor 132 55.87(n)
    47.94(a)
      100859188  XM_004936416.1  XP_004936473.1 
    lizard
    (Anolis carolinensis)
    Reptilia GPR1326
    G protein-coupled receptor 132
    52(a)
    1 ↔ 1
    1(3546340-3547227)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia gpr1321 G protein-coupled receptor 132 55.13(n)
    48.89(a)
      100145370  NM_001126836.1  NP_001120308.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7973801 probable G-protein coupled receptor 132-like 52.38(n)
    46.18(a)
      797380  XM_001337813.4  XP_001337849.1 


    ENSEMBL Gene Tree for GPR132 (if available)
    TreeFam Gene Tree for GPR132 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for GPR132 gene
    FFAR32  GPR42  GPR682  P2RY82  GPR652  F2RL12  FFAR22  F2RL22  
    FFAR12  GPR422  F2RL32  F2R2  
    5 SIMAP similar genes for GPR132 using alignment to 5 protein entries:     GP132_HUMAN (see all proteins):
    CMKLR1    GPR4    GPR68    GPR17    GPR65

    GPR132 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for GPR132 (see all 421)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1832501751,2
    --105515237(+) CTCTGC/TCTCCT 1 -- ds50010--------
    rs1412211921,2
    --105515456(+) CAGCCC/TGGTTT 1 -- ds50010--------
    rs1503284181,2
    C--105515513(+) GGAAAA/GCCCCT 1 -- ds50010--------
    rs1885721671,2
    C--105515610(+) GTCACA/GGCTGT 1 -- ds50010--------
    rs454404961,2
    C--105515800(-) CAACAT/CGGCAA 1 -- ut313Minor allele frequency- C:0.15WA EA 240
    rs456199411,2
    C--105515829(-) TGAGGT/CCAGGA 1 -- ut313Minor allele frequency- C:0.17WA CSA EA 124
    rs1921788781,2
    --105515851(+) CGTCTC/TGGCCT 1 -- ut310--------
    rs1843897541,2
    --105516070(+) TATGAC/TGGTGC 1 -- ut310--------
    rs454992951,2
    C--105516129(-) TTAATA/GTTTAT 1 -- ut310--------
    rs128903961,2
    C,F,H--105516226(+) CTGCGT/CGGCCT 1 -- ut3110Minor allele frequency- C:0.49NS NA WA EA 810

    HapMap Linkage Disequilibrium report for GPR132 (105515728 - 105531782 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for GPR132:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665589CNV Deletion23128226
    dgv2020n71CNV Loss21882294
    nsv902427CNV Loss21882294
    nsv456458CNV Loss19166990
    nsv902424CNV Loss21882294
    nsv902425CNV Loss21882294
    nsv902421CNV Loss21882294
    nsv9175CNV Gain18304495
    nsv902426CNV Gain21882294
    dgv659e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GPR132
    DNA2.0 Custom Variant and Variant Library Synthesis for GPR132

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606167    OMIM disorders: --

    9 diseases for GPR132:    About MalaCards
    leishmaniasis    tonsillitis    systemic lupus erythematosus    lupus erythematosus
    atherosclerosis    endotheliitis    cerebritis    thyroiditis
    prostatitis


    GPR132 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GPR132
    Human Genome Epidemiology (HuGE) Navigator: GPR132 (2 documents)

    Export disorders for GPR132 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for GPR132 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with GPR132)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Integrative predictive model of coronary artery calcification in atherosclerosis. (PubMed id 19948975)1, 4 McGeachie M....Ramoni M.F. (Circulation 2009)
    2. Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus. (PubMed id 18174230)1, 4 Miyagawa H....Horiuchi T. (Rheumatology (Oxford) 2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The lysophospholipid receptor G2A activates a specific combination of G proteins and promotes apoptosis. (PubMed id 12586833)1, 2 Lin P. and Ye R.D. (J. Biol. Chem. 2003)
    5. Expression of G2A, a receptor for lysophosphatidylcholine, by macrophages in murine, rabbit, and human atherosclerotic plaques. (PubMed id 12482833)1, 2 Rikitake Y.... Yokoyama M. (Arterioscler. Thromb. Vasc. Biol. 2002)
    6. Positron emission tomography imaging analysis of G2A as a negative modifier of lymphoid leukemogenesis initiated by the BCR-ABL oncogene. (PubMed id 12086852)1, 3 Le L.Q....Witte O.N. (Cancer Cell 2002)
    7. A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M. (PubMed id 9770487)1, 2 Weng Z.... Witte O.N. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    8. Identification of 9-hydroxyoctadecadienoic acid and other oxidized free fatty acids as ligands of the G protein-coupled receptor G2A. (PubMed id 16236715)1, 9 Obinata H....Izumi T. (J. Biol. Chem. 2005)
    9. Lysophospholipids of different classes mobilize neutrophil secretory vesicles and induce redundant signaling through G2A. (PubMed id 17475884)1, 9 Frasch S.C....Bratton D.L. (J. Immunol. 2007)
    10. Therapeutic options for transfusion related acute lung injury; the potential of the G2A receptor. (PubMed id 22621271)1 Ellison M.A....Silliman C.C. (Curr. Pharm. Des. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 29933 HGNC: 17482 AceView: GPR132 Ensembl:ENSG00000183484 euGenes: HUgn29933
    ECgene: GPR132 H-InvDB: GPR132

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for GPR132 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GPR132 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for GPR132 gene:
    Search GeneIP for patents involving GPR132

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of GPR132
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     cDNA Clones for GPR132 (G2A/GPR132)   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for GPR132   OriGene RNAi products in human, mouse, rat for GPR132  
     OriGene qPCR primer pairs and template standards for GPR132   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for GPR132  
     OriGene qSTAR qPCR primer pairs in human, mouse for GPR132   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for GPR132   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GPR132   OriGene Custom Protein Services for GPR132  

     
     
     Block miRNA regulation of human, mouse, rat GPR132 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing GPR132
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GPR132 Predesigned siRNA for gene silencing in human, mouse, rat GPR132
     QuantiFast Probe-based Assays in human, mouse, rat GPR132 QuantiTect SYBR Green Assays in human, mouse, rat GPR132
     PCR Arrays including human, mouse, rat GPR132 Search Chromatin IP Primers for GPR132
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GPR132  Search GeneGlobe Interaction Network for GPR132
     Regulatory tfbs in GPR132 promoter
     GenScript Custom Purified and Recombinant Proteins Services for GPR132 GenScript cDNA clones with any tag delivered in your preferred vector for GPR132
     GenScript Custom Assay Services for GPR132 GenScript Custom overexpressing Cell Line Services for GPR132
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for GPR132 (GP132)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     GPR132 antibodies
     Antibodies for GPR132
     See all of Abcam's Antibodies, Kits and Proteins for GPR132
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for GPR132
     Antibodies for GPR132
     ELISAs for GPR132
     CLIAs for GPR132



     Browse ESI BIO Cell Lines and PureStem Progenitors for GPR132
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR132
     SwitchGear 3'UTR luciferase reporter plasmids for GPR132
     SwitchGear Promoter luciferase reporter plasmids for GPR132
     ThermoFisher Antibodies for GPR132
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPR132
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GPR132
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GPR132
     LSBio Antibodies in human, mouse, rat for GPR132
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GPR132 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4