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Aliases for GPR12 Gene

Aliases for GPR12 Gene

  • G Protein-Coupled Receptor 12 2 3
  • Protein Phosphatase 1, Regulatory Subunit 84 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 84 2
  • PPP1R84 3
  • GPCR12 3
  • GPCR21 3

External Ids for GPR12 Gene

Previous GeneCards Identifiers for GPR12 Gene

  • GC13M025312
  • GC13M021312
  • GC13M026262
  • GC13M025130
  • GC13M026230
  • GC13M027331
  • GC13M008152

Summaries for GPR12 Gene

GeneCards Summary for GPR12 Gene

GPR12 (G Protein-Coupled Receptor 12) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and phosphatidylcholine binding. An important paralog of this gene is LPAR1.

UniProtKB/Swiss-Prot for GPR12 Gene

  • Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production.

Gene Wiki entry for GPR12 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR12 Gene

Genomics for GPR12 Gene

Regulatory Elements for GPR12 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GPR12 Gene

Chromosome:
13
Start:
26,755,200 bp from pter
End:
26,760,785 bp from pter
Size:
5,586 bases
Orientation:
Minus strand

Genomic View for GPR12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPR12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR12 Gene

Proteins for GPR12 Gene

  • Protein details for GPR12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47775-GPR12_HUMAN
    Recommended name:
    G-protein coupled receptor 12
    Protein Accession:
    P47775
    Secondary Accessions:
    • Q5T8P3

    Protein attributes for GPR12 Gene

    Size:
    334 amino acids
    Molecular mass:
    36730 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR12 Gene

Proteomics data for GPR12 Gene at MOPED

Post-translational modifications for GPR12 Gene

  • Glycosylation at Asn 8 and Asn 24
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR12 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GPR12 Gene

Domains & Families for GPR12 Gene

Graphical View of Domain Structure for InterPro Entry

P47775

UniProtKB/Swiss-Prot:

GPR12_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR12: view

Function for GPR12 Gene

Molecular function for GPR12 Gene

GENATLAS Biochemistry:
G protein coupled receptor 12
UniProtKB/Swiss-Prot Function:
Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production.

Gene Ontology (GO) - Molecular Function for GPR12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0031210 phosphatidylcholine binding IEA --
genes like me logo Genes that share ontologies with GPR12: view
genes like me logo Genes that share phenotypes with GPR12: view

Animal Models for GPR12 Gene

MGI Knock Outs for GPR12:

Animal Model Products

miRNA for GPR12 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPR12

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for GPR12 Gene

Localization for GPR12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR12 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR12 Gene COMPARTMENTS Subcellular localization image for GPR12 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for GPR12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 8530049
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with GPR12: view

Pathways & Interactions for GPR12 Gene

SuperPathways for GPR12 Gene

genes like me logo Genes that share pathways with GPR12: view

Pathways by source for GPR12 Gene

1 BioSystems pathway for GPR12 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for GPR12 Gene

Gene Ontology (GO) - Biological Process for GPR12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006874 cellular calcium ion homeostasis IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR12: view

No data available for SIGNOR curated interactions for GPR12 Gene

Drugs & Compounds for GPR12 Gene

(2) Drugs for GPR12 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
sphingosine 1-phosphate Pharma Agonist Endogenous agonist at S1P1-5 0
Sphingosylphosphorylcholine Pharma 0

(1) Additional Compounds for GPR12 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sphingosyl phosphorylcholine
Full agonist, Agonist
genes like me logo Genes that share compounds with GPR12: view

Transcripts for GPR12 Gene

mRNA/cDNA for GPR12 Gene

Unigene Clusters for GPR12 Gene

G protein-coupled receptor 12:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPR12

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR12 Gene

No ASD Table

Relevant External Links for GPR12 Gene

GeneLoc Exon Structure for
GPR12
ECgene alternative splicing isoforms for
GPR12

Expression for GPR12 Gene

mRNA expression in normal human tissues for GPR12 Gene

mRNA differential expression in normal tissues according to GTEx for GPR12 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x7.7), Brain - Putamen (basal ganglia) (x6.2), Brain - Cerebellar Hemisphere (x5.9), Brain - Caudate (basal ganglia) (x5.6), and Brain - Cerebellum (x4.8).

SOURCE GeneReport for Unigene cluster for GPR12 Gene Hs.123034

genes like me logo Genes that share expression patterns with GPR12: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GPR12 Gene

Orthologs for GPR12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPR12 35
  • 89.32 (n)
  • 93.11 (a)
GPR12 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPR12 35
  • 93.81 (n)
  • 97.01 (a)
GPR12 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr12 35
  • 90.42 (n)
  • 93.71 (a)
Gpr12 16
Gpr12 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPR12 35
  • 99.6 (n)
  • 100 (a)
GPR12 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr12 35
  • 90.12 (n)
  • 92.22 (a)
oppossum
(Monodelphis domestica)
Mammalia GPR12 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR12 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR12 35
  • 82.13 (n)
  • 88.86 (a)
GPR12 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR12 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr12 35
  • 78.83 (n)
  • 88.04 (a)
zebrafish
(Danio rerio)
Actinopterygii gpr12 35
  • 67.37 (n)
  • 74.85 (a)
gpr12 36
  • 73 (a)
OneToOne
Species with no ortholog for GPR12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR12 Gene

ENSEMBL:
Gene Tree for GPR12 (if available)
TreeFam:
Gene Tree for GPR12 (if available)

Paralogs for GPR12 Gene

(6) SIMAP similar genes for GPR12 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with GPR12: view

Variants for GPR12 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPR12 Gene

Variant ID Type Subtype PubMed ID
nsv455849 CNV Loss 19166990
dgv1567n71 CNV Loss 21882294
nsv899950 CNV Loss 21882294
nsv507687 CNV Insertion 20534489
nsv971 CNV Loss 18451855

Variation tolerance for GPR12 Gene

Residual Variation Intolerance Score: 22.72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR12 Gene

HapMap Linkage Disequilibrium report
GPR12
Human Gene Mutation Database (HGMD)
GPR12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for GPR12 Gene

Disorders for GPR12 Gene

Relevant External Links for GPR12

Genetic Association Database (GAD)
GPR12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR12
genes like me logo Genes that share disorders with GPR12: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR12 Gene

Publications for GPR12 Gene

  1. Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells. (PMID: 12649592) Uhlenbrock K. … Kostenis E. (Cell. Physiol. Biochem. 2003) 23 67
  2. Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors. (PMID: 8530049) Song Z.-H. … Bonner T.I. (Genomics 1995) 2 67
  3. Molecular cloning of a novel putative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system. (PMID: 8262253) Saeki Y. … Yanagihara T. (FEBS Lett. 1993) 2 67
  4. Involvement of GPR12 in the regulation of cell proliferation and survival. (PMID: 22430950) Lu X. … Hu Y. (Mol. Cell. Biochem. 2012) 67
  5. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PMID: 21297633) Anderson C.A. … Rioux J.D. (Nat. Genet. 2011) 67

Products for GPR12 Gene

Sources for GPR12 Gene

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