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Aliases for GPR12 Gene

Aliases for GPR12 Gene

  • G Protein-Coupled Receptor 12 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 84 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 84 2
  • PPP1R84 3
  • GPCR21 3
  • GPCR12 3

External Ids for GPR12 Gene

Previous GeneCards Identifiers for GPR12 Gene

  • GC13M025312
  • GC13M021312
  • GC13M026262
  • GC13M025130
  • GC13M026230
  • GC13M027331
  • GC13M008152

Summaries for GPR12 Gene

GeneCards Summary for GPR12 Gene

GPR12 (G Protein-Coupled Receptor 12) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and phosphatidylcholine binding. An important paralog of this gene is LPAR1.

UniProtKB/Swiss-Prot for GPR12 Gene

  • Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production.

Gene Wiki entry for GPR12 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR12 Gene

Genomics for GPR12 Gene

Regulatory Elements for GPR12 Gene

Enhancers for GPR12 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPR12 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR12 Gene

26,755,200 bp from pter
26,760,785 bp from pter
5,586 bases
Minus strand

Genomic View for GPR12 Gene

Genes around GPR12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR12 Gene

Proteins for GPR12 Gene

  • Protein details for GPR12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G-protein coupled receptor 12
    Protein Accession:
    Secondary Accessions:
    • Q5T8P3

    Protein attributes for GPR12 Gene

    334 amino acids
    Molecular mass:
    36730 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR12 Gene

Proteomics data for GPR12 Gene at MOPED

Post-translational modifications for GPR12 Gene

  • Glycosylation at Asn 8 and Asn 24
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR12 Gene

Domains & Families for GPR12 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR12: view

Function for GPR12 Gene

Molecular function for GPR12 Gene

GENATLAS Biochemistry:
G protein coupled receptor 12
UniProtKB/Swiss-Prot Function:
Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production.

Gene Ontology (GO) - Molecular Function for GPR12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031210 phosphatidylcholine binding IEA --
genes like me logo Genes that share ontologies with GPR12: view
genes like me logo Genes that share phenotypes with GPR12: view

Animal Models for GPR12 Gene

MGI Knock Outs for GPR12:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR12

miRNA for GPR12 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR12 Gene

Localization for GPR12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR12 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GPR12 Gene COMPARTMENTS Subcellular localization image for GPR12 gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for GPR12 Gene

Pathways & Interactions for GPR12 Gene

SuperPathways for GPR12 Gene

genes like me logo Genes that share pathways with GPR12: view

Pathways by source for GPR12 Gene

1 BioSystems pathway for GPR12 Gene

Interacting Proteins for GPR12 Gene

Gene Ontology (GO) - Biological Process for GPR12 Gene


No data available for SIGNOR curated interactions for GPR12 Gene

Drugs & Compounds for GPR12 Gene

(2) Drugs for GPR12 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sphingosine-1-phosphate Pharma Full agonist, Agonist Endogenous agonist at S1P1-5 0
Sphingosylphosphorylcholine Pharma 0

(1) Additional Compounds for GPR12 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sphingosyl phosphorylcholine
Full agonist, Agonist
genes like me logo Genes that share compounds with GPR12: view

Transcripts for GPR12 Gene

mRNA/cDNA for GPR12 Gene

Unigene Clusters for GPR12 Gene

G protein-coupled receptor 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR12 Gene

No ASD Table

Relevant External Links for GPR12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR12 Gene

mRNA expression in normal human tissues for GPR12 Gene

mRNA differential expression in normal tissues according to GTEx for GPR12 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x7.7), Brain - Putamen (basal ganglia) (x6.2), Brain - Cerebellar Hemisphere (x5.9), Brain - Caudate (basal ganglia) (x5.6), and Brain - Cerebellum (x4.8).

SOURCE GeneReport for Unigene cluster for GPR12 Gene Hs.123034

genes like me logo Genes that share expression patterns with GPR12: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GPR12 Gene

Orthologs for GPR12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR12 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPR12 35
  • 89.32 (n)
  • 93.11 (a)
GPR12 36
  • 93 (a)
(Canis familiaris)
Mammalia GPR12 35
  • 93.81 (n)
  • 97.01 (a)
GPR12 36
  • 97 (a)
(Mus musculus)
Mammalia Gpr12 35
  • 90.42 (n)
  • 93.71 (a)
Gpr12 16
Gpr12 36
  • 94 (a)
(Pan troglodytes)
Mammalia GPR12 35
  • 99.6 (n)
  • 100 (a)
GPR12 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Gpr12 35
  • 90.12 (n)
  • 92.22 (a)
(Monodelphis domestica)
Mammalia GPR12 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia GPR12 36
  • 81 (a)
(Gallus gallus)
Aves GPR12 35
  • 82.13 (n)
  • 88.86 (a)
GPR12 36
  • 89 (a)
(Anolis carolinensis)
Reptilia GPR12 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr12 35
  • 78.83 (n)
  • 88.04 (a)
(Danio rerio)
Actinopterygii gpr12 35
  • 67.37 (n)
  • 74.85 (a)
gpr12 36
  • 73 (a)
Species with no ortholog for GPR12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR12 Gene

Gene Tree for GPR12 (if available)
Gene Tree for GPR12 (if available)

Paralogs for GPR12 Gene

Paralogs for GPR12 Gene

(6) SIMAP similar genes for GPR12 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with GPR12: view

Variants for GPR12 Gene

Sequence variations from dbSNP and Humsavar for GPR12 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs768211 -- 26,758,426(-) AATTG(A/T)GAAAG utr-variant-3-prime
rs1927522 -- 26,758,699(+) TCACG(A/G)ATGCT utr-variant-3-prime
rs1887597 -- 26,762,216(-) TCTGT(C/G)AACCA upstream-variant-2KB
rs2479505 -- 26,756,816(+) ACTAT(G/T)GGAGA utr-variant-3-prime
rs2479506 -- 26,761,279(+) ACGCT(C/T)TTTTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GPR12 Gene

Variant ID Type Subtype PubMed ID
nsv455849 CNV Loss 19166990
dgv1567n71 CNV Loss 21882294
nsv899950 CNV Loss 21882294
nsv507687 CNV Insertion 20534489
nsv971 CNV Loss 18451855

Variation tolerance for GPR12 Gene

Residual Variation Intolerance Score: 22.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR12 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR12 Gene

Disorders for GPR12 Gene

Relevant External Links for GPR12

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GPR12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR12 Gene

Publications for GPR12 Gene

  1. Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors. (PMID: 8530049) Song Z.-H. … Bonner T.I. (Genomics 1995) 2 3 4 67
  2. Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells. (PMID: 12649592) Uhlenbrock K. … Kostenis E. (Cell. Physiol. Biochem. 2003) 3 23
  3. Involvement of GPR12 in the regulation of cell proliferation and survival. (PMID: 22430950) Lu X. … Hu Y. (Mol. Cell. Biochem. 2012) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Docking motif-guided mapping of the interactome of protein phosphatase-1. (PMID: 19389623) Hendrickx A. … Bollen M. (Chem. Biol. 2009) 3

Products for GPR12 Gene

Sources for GPR12 Gene