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GPR119 Gene(Protein Coding)

G Protein-Coupled Receptor 119

GCID:
GC0XM130384
GIFtS:
55
Genes Participants
UDN Logo

Aliases for GPR119 Gene

Aliases for GPR119 Gene

  • G Protein-Coupled Receptor 119 2 3 5
  • G-Protein Coupled Receptor 119 4
  • G-Protein Coupled Receptor 2 3
  • GPCR2 3

External Ids for GPR119 Gene

Previous GeneCards Identifiers for GPR119 Gene

  • GC0XM128224
  • GC0XM129243
  • GC0XM129346
  • GC0XM129518
  • GC0XM118912

Summaries for GPR119 Gene

Entrez Gene Summary for GPR119 Gene

  • This gene encodes a member of the rhodopsin subfamily of G-protein-coupled receptors that is expressed in the pancreas and gastrointestinal tract. The encoded protein is activated by lipid amides including lysophosphatidylcholine and oleoylethanolamide and may be involved in glucose homeostasis. This protein is a potential drug target in the treatment of type 2 diabetes.[provided by RefSeq, Jan 2010]

GeneCards Summary for GPR119 Gene

GPR119 (G Protein-Coupled Receptor 119) is a Protein Coding gene. Among its related pathways are cAMP signaling pathway and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include G-protein coupled receptor activity and phosphatidylcholine binding. An important paralog of this gene is ADORA1.

UniProtKB/Swiss-Prot for GPR119 Gene

  • Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.

Tocris Summary for GPR119 Gene

  • GPR119 receptors, also referred to as SNORF25, RUP3, GPCR2 and OSGPR116, are Galphas-protein-coupled receptors with a degree of homology to cannabinoid receptors. They are predominantly expressed in the pancreas and gastrointestinal tract in humans and rodents.

Gene Wiki entry for GPR119 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR119 Gene

Genomics for GPR119 Gene

Products:

  1. Regulatory Element

Regulatory Elements for GPR119 Gene

Enhancers for GPR119 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPR119 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the GPR119 gene promoter:

Genomic Location for GPR119 Gene

Chromosome:
X
Start:
130,384,345 bp from pter
End:
130,385,537 bp from pter
Size:
1,193 bases
Orientation:
Minus strand

Genomic View for GPR119 Gene

Genes around GPR119 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR119 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR119 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GPR119 Gene

Proteins for GPR119 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for GPR119 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDV5-GP119_HUMAN
    Recommended name:
    Glucose-dependent insulinotropic receptor
    Protein Accession:
    Q8TDV5
    Secondary Accessions:
    • Q495H7
    • Q4VBN3

    Protein attributes for GPR119 Gene

    Size:
    335 amino acids
    Molecular mass:
    36889 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR119 Gene

Proteomics data for GPR119 Gene at MOPED

Protein Expression for GPR119 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for GPR119 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPR119 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR119 Gene

Domains & Families for GPR119 Gene

Gene Families for GPR119 Gene

HGNC:
IUPHAR :

Protein Domains for GPR119 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR119 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TDV5

UniProtKB/Swiss-Prot:

GP119_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR119: view

Function for GPR119 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for GPR119 Gene

UniProtKB/Swiss-Prot Function:
Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.

Gene Ontology (GO) - Molecular Function for GPR119 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031210 phosphatidylcholine binding IEA --
genes like me logo Genes that share ontologies with GPR119: view

Phenotypes for GPR119 Gene

MGI mutant phenotypes for GPR119:
inferred from 1 alleles
GenomeRNAi human phenotypes for GPR119:
genes like me logo Genes that share phenotypes with GPR119: view

Animal Models for GPR119 Gene

MGI Knock Outs for GPR119:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR119

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GPR119 Gene

Localization for GPR119 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR119 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR119 Gene COMPARTMENTS Subcellular localization image for GPR119 gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for GPR119 Gene

Pathways & Interactions for GPR119 Gene

genes like me logo Genes that share pathways with GPR119: view

Interacting Proteins for GPR119 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000276218%0d%0a9606.ENSP00000350005%0d%0a9606.ENSP00000308024%0d%0a9606.ENSP00000387662%0d%0a9606.ENSP00000360141%0d%0a9606.ENSP00000358081%0d%0a
Selected Interacting proteins: ENSP00000276218 for GPR119 Gene via STRING

Gene Ontology (GO) - Biological Process for GPR119 Gene

None

No data available for SIGNOR curated interactions for GPR119 Gene

Drugs & Compounds for GPR119 Gene

Products:

  1. Drug

(38) Drugs for GPR119 Gene - From: DrugBank, DGIdb, and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
APD668 Investigational Pharma agonist, Target 0
(R)-N-oleoyltyrosinol Pharma Agonist 0
(S)-N-oleoyltyrosinol Pharma Agonist 0
1-oleoyl glycerol Pharma Agonist 0
1-palmitoyl-lysophosphatidylcholine Pharma Agonist 0

(5) Additional Compounds for GPR119 Gene - From: IUPHAR and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-methyl-2-propanyl 1-(3-pyridinyl)-4,4-bipiperidine-1-carboxylate
Agonist
oleoylethanolamide
Agonist
AS 1269574
330981-72-1
Oleylethanolamide
111-58-0
PSN 375963 hydrochloride
388575-52-8

(3) Tocris Compounds for GPR119 Gene

Compound Action Cas Number
AS 1269574 GPR119 receptor agonist 330981-72-1
Oleylethanolamide GPR55 agonist; also PPARalpha agonist 111-58-0
PSN 375963 hydrochloride GPR119 receptor agonist 388575-52-8
genes like me logo Genes that share compounds with GPR119: view

Transcripts for GPR119 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for GPR119 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR119 Gene

G protein-coupled receptor 119:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR119 Gene

No ASD Table

Relevant External Links for GPR119 Gene

GeneLoc Exon Structure for
GPR119
ECgene alternative splicing isoforms for
GPR119

Expression for GPR119 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for GPR119 Gene

mRNA expression in normal human tissues for GPR119 Gene
mRNA expression by BioGPS for GPR119 GenemRNA expression by GTEx for GPR119 Gene

mRNA differential expression in normal tissues according to GTEx for GPR119 Gene

This gene is overexpressed in Pancreas (x39.8) and Testis (x7.7).

Protein differential expression in normal tissues from HIPED for GPR119 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR119 Gene



SOURCE GeneReport for Unigene cluster for GPR119 Gene Hs.496762

mRNA Expression by UniProt/SwissProt for GPR119 Gene

Q8TDV5-GP119_HUMAN
Tissue specificity: Predominantly expressed in the pancreas, especially in the islets.
genes like me logo Genes that share expression patterns with GPR119: view

Protein tissue co-expression partners for GPR119 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GPR119 Gene

Orthologs for GPR119 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPR119 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia GPR119 35
  • 84.78 (n)
  • 79.1 (a)
GPR119 36
  • 79 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia GPR119 35
  • 88.26 (n)
  • 84.18 (a)
GPR119 36
  • 84 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Gpr119 35
  • 84.48 (n)
  • 82.09 (a)
Gpr119 16
Gpr119 36
  • 82 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia GPR119 35
  • 99.8 (n)
  • 99.7 (a)
GPR119 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Gpr119 35
  • 84.29 (n)
  • 81.82 (a)
oppossum
(Monodelphis domestica)
 Mammalia GPR119 36
  • 74 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves GPR119 35
  • 62.99 (n)
  • 55.52 (a)
GPR119 36
  • 53 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia GPR119 36
  • 50 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii LOC100001479 35
  • 51.5 (n)
  • 44.79 (a)
GPR119 36
  • 41 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta CG12796 36
  • 19 (a)
 OneToOne
Species with no ortholog for GPR119:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR119 Gene

ENSEMBL:
Gene Tree for GPR119 (if available)
TreeFam:
Gene Tree for GPR119 (if available)

Paralogs for GPR119 Gene

Paralogs for GPR119 Gene

genes like me logo Genes that share paralogs with GPR119: view

Variants for GPR119 Gene

Sequence variations from dbSNP and Humsavar for GPR119 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs5975187 - 130,384,522(+) TGGCC(A/G)AGAGA reference, missense
rs747670232 -- 130,384,536(+) AGGAG(A/G)AATGA reference, synonymous-codon
rs747698447 -- 130,386,250(+) TAACA(A/G)CTGTC upstream-variant-2KB
rs747842498 -- 130,384,698(+) TGGCA(A/G)GCCAC reference, synonymous-codon
rs748026531 -- 130,385,483(+) GGCAT(A/G)CTATC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for GPR119 Gene

Variant ID Type Subtype PubMed ID
nsv528290 CNV Gain 19592680

Variation tolerance for GPR119 Gene

Residual Variation Intolerance Score: 31.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.79% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GPR119 Gene

Disorders for GPR119 Gene

Relevant External Links for GPR119

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR119

No disorders were found for GPR119 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR119 Gene

Publications for GPR119 Gene

  1. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. (PMID: 14623098) Fredriksson R. … Schioeth H.B. (FEBS Lett. 2003) 2 3 4 67
  2. Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S. … Mitaku S. (FEBS Lett. 2002) 2 3
  3. A lincRNA-DYNLRB2-2/GPR119/GLP-1R/ABCA1-dependent signal transduction pathway is essential for the regulation of cholesterol homeostasis. (PMID: 24493833) Hu Y.W. … Wang Q. (J. Lipid Res. 2014) 3
  4. Discovery and characterization of novel small molecule agonists of G protein-coupled receptor 119. (PMID: 24681896) Zhang S.Y. … Xie X. (Acta Pharmacol. Sin. 2014) 3
  5. GPR119 expression in normal human tissues and islet cell tumors: evidence for its islet-gastrointestinal distribution, expression in pancreatic beta and alpha cells, and involvement in islet function. (PMID: 22883930) Odori S. … Nakao K. (Metab. Clin. Exp. 2013) 3

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