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GPR119 Gene

protein-coding   GIFtS: 53
GCID: GC0XM129518

G Protein-Coupled Receptor 119

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
G Protein-Coupled Receptor 1191 2
GPCR22 5
G-Protein Coupled Receptor 22
Glucose-Dependent Insulinotropic Receptor2
G-Protein Coupled Receptor 1193

External Ids:    HGNC: 190601   Entrez Gene: 1397602   Ensembl: ENSG000001472627   OMIM: 3005135   UniProtKB: Q8TDV53   

Export aliases for GPR119 gene to outside databases

Previous GC identifers: GC0XM128224 GC0XM129243 GC0XM129346 GC0XM118912


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GPR119 Gene:
This gene encodes a member of the rhodopsin subfamily of G-protein-coupled receptors that is expressed in the
pancreas and gastrointestinal tract. The encoded protein is activated by lipid amides including
lysophosphatidylcholine and oleoylethanolamide and may be involved in glucose homeostasis. This protein is a
potential drug target in the treatment of type 2 diabetes.(provided by RefSeq, Jan 2010)

GeneCards Summary for GPR119 Gene:
GPR119 (G protein-coupled receptor 119) is a protein-coding gene. GO annotations related to this gene include phosphatidylcholine binding and G-protein coupled receptor activity. An important paralog of this gene is ADORA1.

UniProtKB/Swiss-Prot: GP119_HUMAN, Q8TDV5
Function: Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine
(LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G
proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway

summary for GPR119 Gene:
GPR119 receptors, also referred to as SNORF25, RUP3, GPCR2 and OSGPR116, are Galphas-protein-coupled
receptors with a degree of homology to cannabinoid receptors. They are predominantly expressed in the
pancreas and gastrointestinal tract in humans and rodents. High expression levels are also seen in many
areas of the rat brain, including the cerebellum, cerebral cortex, chorid plexus, dorsal root ganglion,
hippocampus and hypothalamus. Ethanolamides are proposed to be the endogenous ligands for GPR119.
Oleoylethanolamide (OEA) is the most potent endogenous GPR119 agonist identified to date, and the compound's
effects on feeding are mediated through this receptor. GPR119 receptors are proposed to play a role in
glucose homeostasis through modulation of insulin secretion. Activation of GPR119 receptors potentiates
glucose-stimulated insulin secretion in a manner analogous to that of the incretin hormones glucagon-like
peptide 1 (GLP-1) and gastric inhibitory poylpeptide (GIP). In addition, GPR119 agonists have been shown to
directly stimulate GLP-1 and GIP secretion, which are both powerful antihyperglycemic agents. GPR119
receptors are attracting attention from antidiabetes and antiobesity researchers, as receptor modulation may
provide favorable effects on glucose homeostasis, food intake, weight gain and possibly beta-islet cell
preservation.

Gene Wiki entry for GPR119 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_011786.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the GPR119 gene promoter:
         GR   LHX3b/Lhx3b   AML1a   FOXD1   MEF-2A   LHX3a/Lhx3a   Meis-1a   GR-alpha   aMEF-2   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPR119 promoter sequence
   Search Chromatin IP Primers for GPR119

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GPR119


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq26.1   Ensembl cytogenetic band:  Xq26.1   HGNC cytogenetic band: Xq26.1

GPR119 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPR119 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM129518:  view genomic region     (about GC identifiers)

Start:
129,518,319 bp from pter      End:
129,519,511 bp from pter
Size:
1,193 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GP119_HUMAN, Q8TDV5 (See protein sequence)
Recommended Name: Glucose-dependent insulinotropic receptor  
Size: 335 amino acids; 36889 Da
Secondary accessions: Q495H7 Q4VBN3

Explore the universe of human proteins at neXtProt for GPR119: NX_Q8TDV5

Explore proteomics data for GPR119 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See GPR119 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_848566.1  
    ENSEMBL proteins: 
     ENSP00000276218  
    Reactome Protein details: Q8TDV5

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    antibodies-online kits for GPR119 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GPCRAO: GPCR / Class A : Orphans

    IUPHAR Guide to PHARMACOLOGY protein family classification: GPR119
    GPR18, GPR55 and GPR119
    Class A Orphans

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR028336 GPR119
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8TDV5

    ProtoNet protein and cluster: Q8TDV5

    1 Blocks protein domain: IPB001064 Beta and gamma crystallin

    UniProtKB/Swiss-Prot: GP119_HUMAN, Q8TDV5
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with GPR119           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GP119_HUMAN, Q8TDV5
    Function: Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine
    (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G
    proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0031210phosphatidylcholine binding IEA--
         
    Find genes that share ontologies with GPR119           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GPR119:
     Decreased POU5F1-GFP protein e 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Gpr119):
     endocrine/exocrine gland  growth/size/body  homeostasis/metabolism 

    Find genes that share phenotypes with GPR119           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Gpr119tm1Jleo for GPR119

       genOway: Develop your customized and physiologically relevant rodent model for GPR119

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GP119_HUMAN, Q8TDV5: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--
    GO:0043235receptor complex IDA--

    Find genes that share ontologies with GPR119           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GPR119 About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Incretin Synthesis, Secretion, and Inactivation
    Incretin Synthesis, Secretion, and Inactivation0.88
    Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)0.00
    Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)0.88
    2Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    Rap1 Pathway0.57
    Actin-Based Motility by Rho Family GTPases0.62
    3GPCR Pathway
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    4TGF-Beta Pathway
    MAPK Family Pathway0.60
    JNK Pathway0.51
    5CREB Pathway
    CREB Pathway0.68
    Intracellular Calcium Signaling0.50


    Find genes that share SuperPaths with GPR119           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GPR119 (see all 14)
        Actin-Based Motility by Rho Family GTPases
    Paxillin Interactions
    Intracellular Calcium Signaling
    Rap1 Pathway
    JNK Pathway

    2 Reactome Pathways for GPR119
        Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
    Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)


    1 Kegg Pathway  (Kegg details for GPR119):
        Insulin secretion

        Pathway & Disease-focused RT2 Profiler PCR Array including GPR119: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for GPR119

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for GPR119 (ENSP000002762184) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GCGENSP000003876624STRING: ENSP00000387662
    PCSK1ENSP000003080244STRING: ENSP00000308024
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0030073insulin secretion IEA--

    Find genes that share ontologies with GPR119           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for GPR119
      Browse compounds at ApexBio 

    Compounds for GPR119 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PSN 375963 hydrochlorideGPR119 receptor agonist[388575-52-8]
    AS 1269574GPR119 receptor agonist[330981-72-1]

    Selected IUPHAR Ligands for GPR119 (GPR119) (see all 35)    About this table
    LigandTypeActionAffinityPubmed IDs
    compound 8g [PMID:21444206]
    AgonistAgonist9.321444206
    compound 23 [PMID:21444206]
    AgonistAgonist9.2221444206
    compound 29a [PMID:21444206]
    AgonistAgonist9.1521444206
    compound 3j [PMID:21444206]
    AgonistAgonist9.0521444206
    compound 3a [PMID:21444206]
    AgonistAgonist8.9621444206
    5-(4-cyano-3-methylphenyl)-2-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)nicotinitrile
    AgonistAgonist8.7721939274
    compound 36j [PMID:21536438]
    AgonistAgonist8.5221536438
    compound 58 [PMID:21273063]
    AgonistAgonist8.421273063
    AR231453
    AgonistAgonist8.217289847
    compound 42 [PMID:22545772]
    AgonistAgonist8.122545772



    Find genes that share compounds with GPR119           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GPR119 gene: 
    NM_178471.2  

    Unigene Cluster for GPR119:

    G protein-coupled receptor 119
    Hs.496762  [show with all ESTs]
    Unigene Representative Sequence: NM_178471
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000276218(uc011muv.2)
    miRNA
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    Additional mRNA sequence: 

    AY288416.1 BC095502.1 BC101166.1 BC101167.1 BC101168.2 BC126179.1 BC126181.1 

    1 DOTS entry:

    DT.102821017 

    11 AceView cDNA sequences:

    CN837339 CN837348 AY288416 CN836121 NM_178471 CD630065 CN836350 CD630064 
    CD630063 CN836845 CA841236 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GPR119 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCTAGGAG
    GPR119 Expression
    About this image

    GPR119 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GPR119 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.496762

    UniProtKB/Swiss-Prot: GP119_HUMAN, Q8TDV5
    Tissue specificity: Predominantly expressed in the pancreas, especially in the islets

        Pathway & Disease-focused RT2 Profiler PCR Array including GPR119: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GPR119 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpr1191 , 5 G-protein coupled receptor 1191, 5 84.48(n)1
    82.09(a)1
      X (25.69 cM)5
    2367811  NM_181751.21  NP_861416.11 
     486679795 
    chicken
    (Gallus gallus)
    Aves GPR1191 G protein-coupled receptor 119 62.99(n)
    55.52(a)
      428690  XM_004940569.1  XP_004940626.1 
    lizard
    (Anolis carolinensis)
    Reptilia GPR1196
    G protein-coupled receptor 119
    50(a)
    1 ↔ 1
    GL343451.1(302855-303847)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000014791 glucose-dependent insulinotropic receptor-like 51.5(n)
    44.79(a)
      100001479  XM_001337233.5  XP_001337269.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG127966
    --
    19(a)
    1 ↔ 1
    X(6725430-6726717)


    ENSEMBL Gene Tree for GPR119 (if available)
    TreeFam Gene Tree for GPR119 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GPR119 gene
    ADORA12  ADORA2B2  ADORA2A2  

    Find genes that share paralogs with GPR119           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GPR119 (see all 110)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1892441861,2
    --129473965(+) GAACAC/TGTAAA 1 -- ds50010--------
    rs735640731,2
    C,F--129474213(+) GGGGTG/CGGGGA 1 -- ds50011Minor allele frequency- C:0.50WA 2
    rs2000064431,2
    C--129474300(+) AGTGGA/GGAGGA 1 -- ut310--------
    rs2016488911,2
    C--129474330(+) CTCTGC/TCCTTA 1 -- ut310--------
    rs1382090541,2
    F--129474384(+) GACAGG/CAACTT 2 /S /C mis11Minor allele frequency- C:0.00NA 4552
    rs59751871,2,,4
    C,F,H--129474423(+) TGGCCG/AAGAGA 2 /S /L mis1 ese3 trp37Minor allele frequency- A:0.01NS EA NA 5072
    rs2003874391,2
    C--129474568(+) CCGTTC/GCAGCA 2 Q E mis10--------
    rs413104521,2
    C,F--129474643(+) GGATAG/CAGCAA 2 /L /V mis11Minor allele frequency- C:0.00NA 4548
    rs2007910121,2
    --129474714(+) ATCGAC/TAACCT 2 Y C mis10--------
    rs1402459471,2
    C,F--129474727(+) AGCCAT/CGGCTC 2 /M /V mis11Minor allele frequency- C:0.00NA 4534

    HapMap Linkage Disequilibrium report for GPR119 (129518319 - 129519511 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for GPR119:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv528290CNV Gain19592680

    Locus Specific Mutation Databases (LSDB): GPR119

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GPR119
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300513    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for GPR119:
    Diabetes mellitus

    Find genes that share disorders with GPR119           About GenesLikeMe


    Export disorders for GPR119 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GPR119 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with GPR119)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. (PubMed id 14623098)1, 2, 3 Fredriksson R....Schioeth H.B. (FEBS Lett. 2003)
    2. Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878)1, 2, 3 Takeda S.... Mitaku S. (FEBS Lett. 2002)
    3. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. (PubMed id 16517404)1, 2 Overton H.A.... Reynet C. (Cell Metab. 2006)
    4. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. GPR119 expression in normal human tissues and islet cell tumors: evidence for its islet-gastrointestinal distribution, expression in pancreatic beta and alpha cells, and involvement in islet function. (PubMed id 22883930)1 Odori S....Nakao K. (Metab. Clin. Exp. 2013)
    7. GPR119 regulates genetic markers of fatty acid oxidation in cultured skeletal muscle myotubes. (PubMed id 23069642)1 Cornall L.M....McAinch A.J. (Mol. Cell. Endocrinol. 2013)
    8. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. N-oleoyldopamine enhances glucose homeostasis through the activation of GPR119. (PubMed id 19901198)1 Chu Z.L....Leonard J. (Mol. Endocrinol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 139760 HGNC: 19060 AceView: GPR119 Ensembl:ENSG00000147262 euGenes: HUgn139760
    ECgene: GPR119 Kegg: 139760 H-InvDB: GPR119

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for GPR119 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GPR119 gene:
    Search GeneIP for patents involving GPR119

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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