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GPR119 Gene

protein-coding GIFtS: 47

GC0XM129346

G protein-coupled receptor 119
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
GPCR2 ^¹, ²
MGC119957 ^²
OTTHUMP00000024018 ^²
hGPCR2 ^¹, ²

Descriptions
G protein-coupled receptor 119 ^²
G-protein coupled receptor 119 ^³
G-protein coupled receptor 2 ^²

External Ids
HGNC: 19060¹
Entrez Gene: 139760²
UniProtKB: Q8TDV5³
Ensembl: ENSG00000147262⁷

Search outside databases for aliases for GPR119 gene

Previous GC identifers: GC0XM128224 GC0XM129243

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for GPR119:

GPR119 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et

al., 2003 [PubMed 14623098]).[supplied by OMIM]

UniProtKB/Swiss-Prot: GP119_HUMAN, Q8TDV5

Function: Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and

lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The

activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act

through a G(s) mediated pathway

Gene Wiki entry for GPR119

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GPR119 gene

Entrez Gene cytogenetic band: Xq25 Ensembl cytogenetic band: Xq25 HGNC cytogenetic band: Xq26.1

GPR119 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM129346: (about GC identifiers)

Start:	129,346,095 bp from pter
End:	129,347,102 bp from pter
Size:	1,008 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000023.9 NT_011786.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: GP119_HUMAN, Q8TDV5 (See protein sequence)

Recommended Name: Glucose-dependent insulinotropic receptor

Size: 335 amino acids; 36889 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: Q495H7 Q4VBN3

REFSEQ proteins: NP_848566.1

ENSEMBL proteins:

ENSP00000276218

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (GPCR GPR119)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for GPR119:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (GPCR GPR119), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (GPR119)
	Novus Biologicals Antibodies for GPR119

Assays for GPR119:

	Invitrogen Assays for GPR119
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q8TDV5

ProtoNet protein and cluster: Q8TDV5

1 Blocks protein family: IPB001064 Beta and gamma crystallin

UniProtKB/Swiss-Prot: GP119_HUMAN, Q8TDV5

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GPR119)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GPR119)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_066873

Applied Biosystems Silencer® siRNAs for GPR119

Sigma-Aldrich siRNA and siRNA Panels for GPR119

Sigma-Aldrich shRNA Panels and shRNA for GPR119

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for GPR119
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_178471
Myc/DDK tagged cDNA clone in CMV expression vector: NM_178471
untagged cDNA clone in CMV expression vector: NM_178471

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_178471

UniProtKB/Swiss-Prot: GP119_HUMAN, Q8TDV5

Function: Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and

lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The

activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act

through a G(s) mediated pathway

1 MGI phenotypic allele for Gpr119 (no phenotypes)

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001619	lysosphingolipid and lysophosphatidic acid receptor activity	IEA	--
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0008289	lipid binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Interacting protein for GPR119 (ENSP00000276218³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FFAR1	ENSP00000246553³	STRING (score=.708)

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	IEA	--
GO:0007186	G-protein coupled receptor protein signaling pathway	IEA	--
GO:0030073	insulin secretion	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for GPR119 available from Tocris Bioscience

Compound	Action	CAS number
PSN 375963 hydrochloride	GPR119 receptor agonist	[388575-52-8]
Oleylethanolamide	GPR55 agonist. Also PPARalpha agonist	[111-58-0]

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GPR119)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GPR119)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_066873

Sigma-Aldrich siRNA and siRNA Panels for GPR119

Sigma-Aldrich shRNA Panels and shRNA for GPR119

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_178471

REFSEQ mRNAs for GPR119 gene:

NM_178471.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_178471

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_178471
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_178471
                                 untagged cDNA clone in CMV expression vector: NM_178471

Additional cDNA sequence:

AY288416.1 BC095502.1 BC101166.1 BC101167.1 BC101168.2 BC126179.1 BC126181.1

1 DOTS entry:

DT.102821017

11 AceView cDNA sequences:

CN837348 CN837339 CN836121 AY288416 NM_178471 CD630065 CN836350 CD630064

CN836845 CD630063 CA841236

highest scoring ESTs for GPR119:

AY288416 CA841236 CD630063 CD630064 CD630065 CN836121 CN836350 CN836845 CN837339 CN837348

Unigene Cluster for GPR119:

G protein-coupled receptor 119

Hs.496762 [show with all ESTs]

Unigene Representative Sequence: BC126179

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000276218

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

GPR119 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GPR119

¹ Data from GNF BioGPS
About these images

About these images

CGAP SAGE TAG: GCCCTAGGAG

SOURCE GeneReport for Unigene cluster: Hs.496762
UniProtKB/Swiss-Prot: GP119_HUMAN, Q8TDV5
Tissue specificity: Predominantly expressed in the pancreas, especially in the islets

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GPR119 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GPR119¹	--	G protein-coupled receptor 119	88.26(n) 84.18(a)	492134 XM_549255.1 XP_549255.1
chimpanzee (Pan troglodytes)	GPR119¹	--	G protein-coupled receptor 119	99.8(n) 99.7(a)	465858 XM_521262.2 XP_521262.2
cow (Bos taurus)	GPR119¹	--	G protein-coupled receptor 119	84.78(n) 79.1(a)	524232 XM_602553.2 XP_602553.2
rat (Rattus norvegicus)	Gpr119¹	--	G protein-coupled receptor 119	84.29(n) 81.82(a)	302813 NM_181770.1 NP_861435.1
mouse (Mus musculus)	Gpr119^{1, 5}	X⁵	G-protein coupled receptor 119^{1, 5}	84.48(n)¹ 82.09(a)¹	236781¹ NM_181751.2¹ NP_861416.1¹ AB233291⁵ AL672042⁵ (see all 8)

About this table Species with no ortholog for GPR119

ENSEMBL Gene Tree for GPR119

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for GPR119 gene

ADORA2B² ADORA2A²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/11 NCBI SNPs in GPR119 are shown (see all 11 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 9)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs5975187^1,2	H	129346177(+)	`TGGCCG/AAGAGA`	1	L/S	mis¹ ese³ trp³		4		EU EA WA	406
--	rs16999669^1,2	F	129348545(+)	`TATTCT/CAGTTG`	1	--	ng3¹ tfbs³		3		NA	106
--	rs12843361^1,2	--	129348877(+)	`agtttC/Tgctct`	1	--	ng3¹		0	--	--	--	--
--	rs73564073^1,2	--	129345967(+)	`GGGGTC/GGGGGA`	1	--	ng5¹		0	--	--	--	--
--	rs12850013^1,2	--	129348855(+)	`tttttA/Tttttt`	1	--	ng3¹ tfbs³ trp³		0	--	--	--	--
--	rs41310452^1,2	--	129346397(+)	`GGATAC/GAGCAA`	1	L/V	mis¹		0	--	--	--	--
--	rs57168681^1,2	--	129345910(+)	`ATGGG-/GAAACTG`	1	--	ng5¹		0	--	--	--	--
--	rs34483672^1,2	--	129346323(+)	`GTTCC-/CAGCAC`	1	L/R	fra¹		0	--	--	--	--
--	rs59702029^1,2	--	129347965(+)	`ACTAAC/TTGATA`	1	--	ng3¹		0	--	--	--	--
--	rs41301493^1,2	--	129346718(+)	`CCACAA/GCCCGG`	1	L/L	syn¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for GPR119 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 300513

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

7 PubMed articles for GPR119 gene:

Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. (PubMed id 14623098)^{2, 3, 4} Fredriksson R....Schioth H.B. (2003)
Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878)^{2, 3, 4} Takeda S.... Mitaku S. (2002)
Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. (PubMed id 16517404)^{3, 4} Overton H.A.... Reynet C. (2006)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{3, 4} Ross M.T.... Bentley D.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor. (PubMed id 15607732)⁴ Soga T.... Furuichi K. (2005)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 139760	HGNC: 19060	AceView: GPR119	Ensembl:ENSG00000147262	euGenes: HUgn139760
ECgene: GPR119	H-InvDB: GPR119

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for GPR119
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for GPR119:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GPR119-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GPR119		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for GPR119		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Tocris compounds for GPR119

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for GPR119

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GPR119 Gene

protein-coding GIFtS: 47

Aliases &
Descriptions
for GPR119

Summaries
for GPR119

Genomic Location
for GPR119

Proteins
for GPR119

Protein Domains/
Families
for GPR119

Gene Function
for GPR119

Pathways & Interactions
for GPR119

Drugs & Compounds
for GPR119

Transcripts
for GPR119

Expression
for GPR119

Orthologs
for GPR119

Paralogs
for GPR119

SNPs/Variants
for GPR119

Disorders & Mutations
for GPR119

Medical News
for GPR119

Publications
for GPR119

Search for GPR119

Genome Databases showing GPR119

Other Databases showing GPR119

Specialized Databases showing GPR119

Licensable Technologies
for GPR119

Services
for GPR119

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GPR119 Gene

protein-coding GIFtS: 47

Aliases & Descriptionsfor GPR119

Summariesfor GPR119

Genomic Locationfor GPR119

Proteinsfor GPR119

Protein Domains/Familiesfor GPR119

Gene Functionfor GPR119

Pathways & Interactionsfor GPR119

Drugs & Compoundsfor GPR119

Transcriptsfor GPR119

Expression for GPR119

Orthologsfor GPR119

Paralogsfor GPR119

SNPs/Variantsfor GPR119

Disorders & Mutationsfor GPR119

Medical Newsfor GPR119

Publicationsfor GPR119

Search for GPR119

Genome Databases showing GPR119

Other Databases showing GPR119

Specialized Databases showing GPR119

Licensable Technologiesfor GPR119

Servicesfor GPR119

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GPR119

Summaries
for GPR119

Genomic Location
for GPR119

Proteins
for GPR119

Protein Domains/
Families
for GPR119

Gene Function
for GPR119

Pathways & Interactions
for GPR119

Drugs & Compounds
for GPR119

Transcripts
for GPR119

Expression
for GPR119

Orthologs
for GPR119

Paralogs
for GPR119

SNPs/Variants
for GPR119

Disorders & Mutations
for GPR119

Medical News
for GPR119

Publications
for GPR119

Licensable Technologies
for GPR119

Services
for GPR119