GPR119 Gene

Aliases
for GPR119 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC0XM128224 GC0XM129243 GC0XM129346 GC0XM118912

Summaries
for GPR119 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for GPR119 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000023.10  NC_018934.2  NT_011786.17  

SwitchGear Promoter luciferase reporter plasmid: GPR119 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GPR119

GPR119 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM129518:  view genomic region     (about GC identifiers)

Proteins
for GPR119 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for GPR119: NX_Q8TDV5

Explore proteomics data for GPR119 at MOPED

Post-translational modifications: 

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Domains /
Families
for GPR119 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q8TDV5

Find genes that share domains with GPR119           About GenesLikeMe

Function
for GPR119 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

(inferred from 1 allele) (MGI details for Gpr119)

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR119

Flow Cytometry Products:

eBioscience FlowRNA Probe Sets ( VA4-10975 VA6-10927) for GPR119

Localization
for GPR119 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
plasma membrane	5
nucleus	1

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Gene Ontology (GO): 3 cellular component terms:    About this table

Pathways & Interactions
for GPR119 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for GPR119 About   (see all 12)   See pathways by source

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	SuperPath	Contained pathways About
1	Incretin Synthesis, Secretion, and Inactivation	Incretin Synthesis, Secretion, and Inactivation 0.88 Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 0.00 Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1) 0.88
2	Apoptotic Pathways in Synovial Fibroblasts	PPAR Pathway 0.66 Rap1 Pathway 0.57 Actin-Based Motility by Rho Family GTPases 0.62
3	GPCR Pathway	Paxillin Interactions 0.73 NFAT in Immune Response 0.58 GPCR Pathway 0.62
4	TGF-Beta Pathway	MAPK Family Pathway 0.60 JNK Pathway 0.51
5	CREB Pathway	CREB Pathway 0.68 Intracellular Calcium Signaling 0.50

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GPR119

	Actin-Based Motility by Rho Family GTPases
	Paxillin Interactions
	Intracellular Calcium Signaling
	Rap1 Pathway
	JNK Pathway

2 Reactome Pathways for GPR119

	Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
	Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)

1 Kegg Pathway  (Kegg details for GPR119)

Insulin secretion

Gene Ontology (GO): 2 biological process terms:    About this table

Drugs & Compounds
for GPR119 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for GPR119 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for GPR119 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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GPR119 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GCCCTAGGAG

About this image

Primer Products:		OriGene qPCR primer pairs and template standards for GPR119 OriGene qSTAR qPCR primer pairs in human, mouse for GPR119
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR119

Orthologs
for GPR119 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for GPR119 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for GPR119 gene

ADORA1²  ADORA2B²  ADORA2A²  

Find genes that share paralogs with GPR119           About GenesLikeMe

Genomic Variants
for GPR119 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for GPR119 (see all 110)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1892441861,2		--	129473965(+)	GAACAC/TGTAAA	1	--	ds5001		0	--	--	--	--
rs735640731,2	C,F	--	129474213(+)	GGGGTG/CGGGGA	1	--	ds5001		1		WA	2
rs2000064431,2	C	--	129474300(+)	AGTGGA/GGAGGA	1	--	ut31		0	--	--	--	--
rs2016488911,2	C	--	129474330(+)	CTCTGC/TCCTTA	1	--	ut31		0	--	--	--	--
rs1382090541,2	F	--	129474384(+)	GACAGG/CAACTT	2	/S /C	mis1		1		NA	4552
rs59751871,2,,4	C,F,H	--	129474423(+)	TGGCCG/AAGAGA	2	/S /L	mis1 ese3 trp3		7		NS EA NA	5072
rs2003874391,2	C	--	129474568(+)	CCGTTC/GCAGCA	2	Q E	mis1		0	--	--	--	--
rs413104521,2	C,F	--	129474643(+)	GGATAG/CAGCAA	2	/L /V	mis1		1		NA	4548
rs2007910121,2		--	129474714(+)	ATCGAC/TAACCT	2	Y C	mis1		0	--	--	--	--
rs1402459471,2	C,F	--	129474727(+)	AGCCAT/CGGCTC	2	/M /V	mis1		1		NA	4534

HapMap Linkage Disequilibrium report for GPR119 (129518319 - 129519511 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for GPR119:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv528290	CNV	Gain	19592680

Locus Specific Mutation Databases (LSDB): GPR119

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing GPR119

DNA2.0 Custom Variant and Variant Library Synthesis for GPR119

Disorders / Diseases
for GPR119 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for GPR119 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for GPR119 gene, integrated from 10 sources (see all 21): (articles sorted by number of sources associating them with GPR119)

Utopia: connect your pdf to the dynamic world of online information

1. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. (PubMed id 14623098)^{1, 2, 3} Fredriksson R....Schioeth H.B. (FEBS Lett. 2003)
2. Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878)^{1, 2, 3} Takeda S.... Mitaku S. (FEBS Lett. 2002)
3. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. (PubMed id 16517404)^{1, 2} Overton H.A.... Reynet C. (Cell Metab. 2006)
4. The DNA sequence of the human X chromosome. (PubMed id 15772651)^{1, 2} Ross M.T.... Bentley D.R. (Nature 2005)
5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
6. GPR119 expression in normal human tissues and islet cell tumors: evidence for its islet-gastrointestinal distribution, expression in pancreatic beta and alpha cells, and involvement in islet function. (PubMed id 22883930)¹ Odori S....Nakao K. (Metab. Clin. Exp. 2013)
7. GPR119 regulates genetic markers of fatty acid oxidation in cultured skeletal muscle myotubes. (PubMed id 23069642)¹ Cornall L.M....McAinch A.J. (Mol. Cell. Endocrinol. 2013)
8. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)¹ Chen Y....Ge F. (amp 2013)
9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (Mol. Cell 2011)
10. N-oleoyldopamine enhances glucose homeostasis through the activation of GPR119. (PubMed id 19901198)¹ Chu Z.L....Leonard J. (Mol. Endocrinol. 2010)

External Searches for GPR119 gene

Genome Databases showing GPR119 gene

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Specialized Databases showing GPR119 gene

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Advanced Cell Diagnostics, Animal models from genOway)
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