Aliases for GPR119 Gene
Aliases for GPR119 Gene
External Ids for GPR119 Gene
- HGNC: 19060
- Entrez Gene: 139760
- Ensembl: ENSG00000147262
- OMIM: 300513
- UniProtKB: Q8TDV5
Previous GeneCards Identifiers for GPR119 Gene
- GC0XM128224
- GC0XM129243
- GC0XM129346
- GC0XM129518
- GC0XM118912
Summaries for GPR119 Gene
-
This gene encodes a member of the rhodopsin subfamily of G-protein-coupled receptors that is expressed in the pancreas and gastrointestinal tract. The encoded protein is activated by lipid amides including lysophosphatidylcholine and oleoylethanolamide and may be involved in glucose homeostasis. This protein is a potential drug target in the treatment of type 2 diabetes.[provided by RefSeq, Jan 2010]
GeneCards Summary for GPR119 Gene
GPR119 (G Protein-Coupled Receptor 119) is a Protein Coding gene. Among its related pathways are Peptide hormone metabolism and NFAT and Cardiac Hypertrophy. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and phosphatidylcholine binding. An important paralog of this gene is ENSG00000198211.
UniProtKB/Swiss-Prot for GPR119 Gene
-
Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.
-
GPR119 receptors, also referred to as SNORF25, RUP3, GPCR2 and OSGPR116, are Galphas-protein-coupled receptors with a degree of homology to cannabinoid receptors. They are predominantly expressed in the pancreas and gastrointestinal tract in humans and rodents.
Additional gene information for GPR119 Gene
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR119 Gene
Genomics for GPR119 Gene
GeneHancer (GH) Regulatory Elements for GPR119 Gene
- Top Transcription factor binding sites by QIAGEN in the GPR119 gene promoter:
Regulatory Element Products
Genomic Locations for GPR119 Gene
- chrX:130,384,345-130,385,537
- (GRCh38/hg38)
- Size:
- 1,193 bases
- Orientation:
- Minus strand
- chrX:129,518,319-129,519,511
- (GRCh37/hg19)
Genomic View for GPR119 Gene
- Cytogenetic band:
-
- Xq26.1 by Ensembl
- Xq26.1 by Entrez Gene
- Xq26.1 by HGNC


RefSeq DNA sequence for GPR119 Gene
Proteins for GPR119 Gene
-
Protein details for GPR119 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8TDV5-GP119_HUMAN
- Recommended name:
- Glucose-dependent insulinotropic receptor
- Protein Accession:
- Q8TDV5
- Q495H7
- Q4VBN3
Protein attributes for GPR119 Gene
- Size:
- 335 amino acids
- Molecular mass:
- 36889 Da
- Quaternary structure:
- No Data Available
Protein Expression for GPR119 Gene
Post-translational modifications for GPR119 Gene
Other Protein References for GPR119 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
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- 5 IHC Antibodies (anti-human)
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- 7 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-mouse)
- 12 IHC (p) Antibodies (anti-mouse)
- 12 WB Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
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Assay Products
No data available for DME Specific Peptides for GPR119 Gene
Domains & Families for GPR119 Gene
Gene Families for GPR119 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- G-protein coupled receptors
- Predicted membrane proteins
Protein Domains for GPR119 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for GPR119 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8TDV5- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for GPR119 Gene
Molecular function for GPR119 Gene
- UniProtKB/Swiss-Prot Function:
- Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G-protein coupled receptor activity | IEA | -- |
GO:0008289 | lipid binding | IEA | -- |
GO:0031210 | phosphatidylcholine binding | IEA | -- |
Phenotypes for GPR119 Gene
- MGI mutant phenotypes for GPR119:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for GPR119:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Decreased NF-kappaB reporter expression
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased POU5F1-GFP protein expression
- Decreased IL-8 secretion
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased homologous recombination repair frequency
- Decreased shRNA abundance
- Downregulation of NFkappaB pathway
Animal Models for GPR119 Gene
- MGI Knock Outs for GPR119:
-
- Gpr119 tm1Jleo
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for GPR119
- genomics-online: cdna clones - Search results for 93 available G Protein-Coupled Receptor 119 gene related products
- Overview of 93 available G Protein-Coupled Receptor 119 gene related products
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No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GPR119 Gene
Localization for GPR119 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GPR119 Gene
- Cell membrane; Multi-pass membrane protein.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0043235 | receptor complex | IDA | 23382219 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR119 Gene
Pathways & Interactions for GPR119 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Apoptotic Pathways in Synovial Fibroblasts |
.66
|
.57
|
2 | GPCR Pathway |
.62
|
|
3 | Incretin synthesis, secretion, and inactivation | ||
4 | CREB Pathway |
.68
|
|
5 | TGF-Beta Pathway |
.51
|
Pathways by source for GPR119 Gene
5 Reactome pathways for GPR119 Gene
2 KEGG pathways for GPR119 Gene
14 Qiagen pathways for GPR119 Gene
Interacting Proteins for GPR119 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G-protein coupled receptor signaling pathway | IEA | -- |
GO:0030073 | insulin secretion | IEA | -- |
No data available for SIGNOR curated interactions for GPR119 Gene
Drugs & Compounds for GPR119 Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
APD668 | Investigational | Pharma | Target, agonist | Potent GPR119 agonist | 0 | |
MBX-2982 | Investigational | Pharma | GPR119 agonist,selective and orally-available | 0 | ||
PSN632408 | Pharma | Agonist | Human and mouse GPR119 agonist | 0 | ||
AS 1269574 | Pharma | GPR119 receptor agonist | 0 | |||
PSN 375963 hydrochloride | Pharma | GPR119 receptor agonist | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
2-methyl-2-propanyl 1-(3-pyridinyl)-4,4-bipiperidine-1-carboxylate |
|
Agonist |
|
|||
oleoylethanolamide |
|
Agonist |
|
(2) Tocris Compounds for GPR119 Gene
Compound | Action | Cas Number |
---|---|---|
AS 1269574 | GPR119 receptor agonist | 330981-72-1 |
PSN 375963 hydrochloride | GPR119 receptor agonist | 388575-52-8 |
(7) ApexBio Compounds for GPR119 Gene
Compound | Action | Cas Number |
---|---|---|
APD668 | Potent GPR119 agonist | 832714-46-2 |
AR 231453 | GPR119 agonist,potent and selective | 733750-99-7 |
AS 1269574 | GPR119 receptor agonist | 330981-72-1 |
GSK1292263 | Novel GPR119 agonist | 1032823-75-8 |
MBX-2982 | GPR119 agonist,selective and orally-available | 1037792-44-1 |
PSN 375963 hydrochloride | 388575-52-8 | |
PSN632408 | Human and mouse GPR119 agonist | 857652-30-3 |
Transcripts for GPR119 Gene
mRNA/cDNA for GPR119 Gene
- (1) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (11) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GPR119 Gene
CRISPR Products
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- VectorBuilder custom plasmid, inducible vectors for GPR119
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for GPR119
- genomics-online: cdna clones - Search results for 93 available G Protein-Coupled Receptor 119 gene related products
- Overview of 93 available G Protein-Coupled Receptor 119 gene related products
- orf clones - Search results for 93 available G Protein-Coupled Receptor 119 gene related products
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-
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Expression for GPR119 Gene
mRNA differential expression in normal tissues according to GTEx for GPR119 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR119 Gene
NURSA nuclear receptor signaling pathways regulating expression of GPR119 Gene:
GPR119SOURCE GeneReport for Unigene cluster for GPR119 Gene:
Hs.496762mRNA Expression by UniProt/SwissProt for GPR119 Gene:
Q8TDV5-GP119_HUMANEvidence on tissue expression from TISSUES for GPR119 Gene
- Pancreas(2.3)
Primer Products
-
OriGene qPCR primer pairs and template standards for GPR119
-
OriGene qPCR primer pairs for GPR119
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR119 Gene
Orthologs for GPR119 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | GPR119 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | GPR119 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | GPR119 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Gpr119 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Gpr119 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | GPR119 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | GPR119 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | GPR119 34 |
|
OneToOne | |
zebrafish (Danio rerio) |
Actinopterygii | LOC100001479 33 |
|
||
GPR119 34 |
|
OneToOne | |||
fruit fly (Drosophila melanogaster) |
Insecta | CG12796 34 |
|
OneToOne |
- Species where no ortholog for GPR119 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for GPR119 Gene
Variants for GPR119 Gene
SNP ID | Clin | Chr 0X pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1002103492 | -- | 130,386,673(-) | G/T | upstream_transcript_variant | |
rs1002539558 | -- | 130,386,178(-) | C/A | upstream_transcript_variant | |
rs1003310680 | -- | 130,383,999(-) | T/C | downstream_transcript_variant | |
rs1008487083 | -- | 130,385,170(-) | A/G | coding_sequence_variant, missense_variant | |
rs1009437218 | -- | 130,386,741(-) | G/A | upstream_transcript_variant |
Additional Variant Information for GPR119 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GPR119
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR119 Gene
Disorders for GPR119 Gene
Additional Disease Information for GPR119
No disorders were found for GPR119 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR119 Gene
Publications for GPR119 Gene
- Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. (PMID: 14623098) Fredriksson R … Schiöth HB (FEBS letters 2003) 2 3 4 58
- Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S … Mitaku S (FEBS letters 2002) 2 3 4 58
- Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. (PMID: 16517404) Overton HA … Reynet C (Cell metabolism 2006) 3 4 58
- The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
Products for GPR119 Gene
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for GPR119
- antibodies-online: Search results for 86 available G Protein-Coupled Receptor 119 Antibodies ranked by validation data
- Compare Top G Protein-Coupled Receptor 119 Antibodies
- Recommended
- 32 WB Antibodies (anti-human)
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- Search GeneTex for Antibodies for GPR119
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- ViGene Biosciences adenoviral particle packaged cDNA for GPR119 gene
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- genomics-online: cdna clones - Search results for 93 available G Protein-Coupled Receptor 119 gene related products
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Sources for GPR119 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
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