Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms of Use
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
GeneCards Plus
- Premium Tools
  
  Learn more

Set Analyses:

VarElect

Advanced Search

GPR119 Gene

protein-coding GIFtS: 53
GCID: GC0XM129518

G Protein-Coupled Receptor 119

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

TryGeneCards Plus

Aliases
G Protein-Coupled Receptor 119¹ ²
GPCR2² ⁵
G-Protein Coupled Receptor 2²
Glucose-Dependent Insulinotropic Receptor²
G-Protein Coupled Receptor 119³

External Ids:	HGNC: 19060¹	Entrez Gene: 139760²	Ensembl: ENSG00000147262⁷	OMIM: 300513⁵	UniProtKB: Q8TDV5³

Export aliases for GPR119 gene to outside databases

Previous GC identifers: GC0XM128224 GC0XM129243 GC0XM129346 GC0XM118912

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for GPR119 Gene:

This gene encodes a member of the rhodopsin subfamily of G-protein-coupled receptors that is expressed in the

pancreas and gastrointestinal tract. The encoded protein is activated by lipid amides including

lysophosphatidylcholine and oleoylethanolamide and may be involved in glucose homeostasis. This protein is a

potential drug target in the treatment of type 2 diabetes.(provided by RefSeq, Jan 2010)

GeneCards Summary for GPR119 Gene:

GPR119 (G protein-coupled receptor 119) is a protein-coding gene. Diseases associated with GPR119 include cerebritis, and islet cell tumor. GO annotations related to this gene include phosphatidylcholine binding and G-protein coupled receptor activity. An important paralog of this gene is ADORA1.

UniProtKB/Swiss-Prot: GP119_HUMAN, Q8TDV5

Function: Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine

(LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G

proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway

summary for GPR119 Gene:

GPR119 receptors, also referred to as SNORF25, RUP3, GPCR2 and OSGPR116, are Galphas-protein-coupled

receptors with a degree of homology to cannabinoid receptors. They are predominantly expressed in the

pancreas and gastrointestinal tract in humans and rodents. High expression levels are also seen in many

areas of the rat brain, including the cerebellum, cerebral cortex, chorid plexus, dorsal root ganglion,

hippocampus and hypothalamus. Ethanolamides are proposed to be the endogenous ligands for GPR119.

Oleoylethanolamide (OEA) is the most potent endogenous GPR119 agonist identified to date, and the compound's

effects on feeding are mediated through this receptor. GPR119 receptors are proposed to play a role in

glucose homeostasis through modulation of insulin secretion. Activation of GPR119 receptors potentiates

glucose-stimulated insulin secretion in a manner analogous to that of the incretin hormones glucagon-like

peptide 1 (GLP-1) and gastric inhibitory poylpeptide (GIP). In addition, GPR119 agonists have been shown to

directly stimulate GLP-1 and GIP secretion, which are both powerful antihyperglycemic agents. GPR119

receptors are attracting attention from antidiabetes and antiobesity researchers, as receptor modulation may

provide favorable effects on glucose homeostasis, food intake, weight gain and possibly beta-islet cell

preservation.

Gene Wiki entry for GPR119 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus

RefSeq DNA sequence:

NC_000023.11 NC_018934.2 NT_011786.17

Regulatory elements:

Regulatory transcription factor binding sites in the GPR119 gene promoter:
GR LHX3b/Lhx3b AML1a FOXD1 MEF-2A LHX3a/Lhx3a Meis-1a GR-alpha aMEF-2 MRF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GPR119 promoter sequence

Search Chromatin IP Primers for GPR119

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GPR119

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq26.1 Ensembl cytogenetic band: Xq26.1 HGNC cytogenetic band: Xq26.1

GPR119 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPR119 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM129518: view genomic region (about GC identifiers)

Start:	129,518,319 bp from pter	End:	129,519,511 bp from pter
Size:	1,193 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: GP119_HUMAN, Q8TDV5 (See protein sequence)

Recommended Name: Glucose-dependent insulinotropic receptor

Size: 335 amino acids; 36889 Da

Secondary accessions: Q495H7 Q4VBN3

Explore the universe of human proteins at neXtProt for GPR119: NX_Q8TDV5

Explore proteomics data for GPR119 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See GPR119 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_848566.1

ENSEMBL proteins:

ENSP00000276218

Reactome Protein details: Q8TDV5

GPR119 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for GPR119 OriGene Custom MassSpec OriGene Custom Protein Services for GPR119
	GenScript Custom Purified and Recombinant Proteins Services for GPR119
	Novus Biologicals GPR119 Protein Novus Biologicals GPR119 Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for GPR119

GPR119 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies for GPR119 OriGene Custom Antibody Services for GPR119
	Novus Biologicals GPR119 Antibodies
	Abcam antibodies for GPR119
	Cloud-Clone Corp. Antibodies for GPR119
	ThermoFisher Antibodies for GPR119
	LSBio Antibodies in human, mouse, rat for GPR119

GPR119 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for GPR119
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for GPR119
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for GPR119 Cloud-Clone Corp. CLIAs for GPR119

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus

HGNC Gene Families:

GPCRAO: GPCR / Class A : Orphans

IUPHAR Guide to PHARMACOLOGY protein family classification: GPR119

GPR18, GPR55 and GPR119

Class A Orphans

3 InterPro protein domains:

IPR017452 GPCR_Rhodpsn_7TM

IPR028336 GPR119

IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q8TDV5

ProtoNet protein and cluster: Q8TDV5

1 Blocks protein domain: IPB001064 Beta and gamma crystallin

UniProtKB/Swiss-Prot: GP119_HUMAN, Q8TDV5

Similarity: Belongs to the G-protein coupled receptor 1 family

GPR119 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

UniProtKB/Swiss-Prot Summary: GP119_HUMAN, Q8TDV5

Function: Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine

(LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G

proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway

Gene Ontology (GO): 2 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0031210	phosphatidylcholine binding	IEA	--

GPR119 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for GPR119:

Decreased POU5F1-GFP protein e

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Gpr119):

endocrine/exocrine gland

growth/size/body

homeostasis/metabolism

GPR119 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Gpr119^tm1Jleo for GPR119

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GPR119

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GPR119

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GPR119

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GPR119

miRNA Products:		Block miRNA regulation of human, mouse, rat GPR119 using miScript Target Protectors
		1 qRT-PCR Assays for microRNA that regulate GPR119:
		hsa-miR-938
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for GPR119
		Predesigned siRNA for gene silencing in human, mouse, rat GPR119

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for GPR119

Clone Products:		OriGene clones in human, mouse for GPR119 (see all 5) OriGene ORF clones in mouse, rat for GPR119 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: GPR119 (NM_178471)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for GPR119
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPR119

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for GPR119
		Browse ESI BIO Cell Lines and PureStem Progenitors for GPR119

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR119

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot

GP119_HUMAN, Q8TDV5: Cell membrane; Multi-pass membrane protein

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
plasma membrane	5
nucleus	1

About this image

Gene Ontology (GO): 3 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral component of membrane	IEA	--
GO:0043235	receptor complex	IDA	--

GPR119 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for GPR119 About (see all 12)

See pathways by source

SuperPath

Contained pathways About

Incretin Synthesis, Secretion, and Inactivation

	Incretin Synthesis, Secretion, and Inactivation	0.88			Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	0.00
	Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)	0.88

Apoptotic Pathways in Synovial Fibroblasts

	PPAR Pathway	0.66			Rap1 Pathway	0.57
	Actin-Based Motility by Rho Family GTPases	0.62

GPCR Pathway

	Paxillin Interactions	0.73			NFAT in Immune Response	0.58
	GPCR Pathway	0.62

TGF-Beta Pathway

MAPK Family Pathway

0.60

JNK Pathway

0.51

CREB Pathway

CREB Pathway

0.68

Intracellular Calcium Signaling

0.50

Pathways by source See SuperPaths
Show all pathways

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GPR119 (see all 14)

	Actin-Based Motility by Rho Family GTPases
	Paxillin Interactions
	Intracellular Calcium Signaling
	Rap1 Pathway
	JNK Pathway

2 Reactome Pathways for GPR119

	Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
	Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)

1 Kegg Pathway (Kegg details for GPR119):

Insulin secretion

GPR119 for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Array including GPR119:

G Protein Coupled Receptors 384HT in human mouse rat

Interactions:

Search GeneGlobe Interaction Network for GPR119

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for GPR119 (ENSP00000276218⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GCG	ENSP00000387662⁴	STRING: ENSP00000387662
PCSK1	ENSP00000308024⁴	STRING: ENSP00000308024
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

Gene Ontology (GO): 2 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007186	G-protein coupled receptor signaling pathway	--	--
GO:0030073	insulin secretion	IEA	--

GPR119 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for GPR119

Browse compounds at ApexBio

Compounds for GPR119 available from Tocris Bioscience About this table

Compound	Action	CAS #
PSN 375963 hydrochloride	GPR119 receptor agonist	[388575-52-8]
AS 1269574	GPR119 receptor agonist	[330981-72-1]

Selected IUPHAR Ligands for GPR119 (GPR119) (see all 35) About this table

Ligand	Type	Action	Affinity	Pubmed IDs
compound 8g [PMID:21444206]	Agonist	Agonist	9.3	21444206
compound 23 [PMID:21444206]	Agonist	Agonist	9.22	21444206
compound 29a [PMID:21444206]	Agonist	Agonist	9.15	21444206
compound 3j [PMID:21444206]	Agonist	Agonist	9.05	21444206
compound 3a [PMID:21444206]	Agonist	Agonist	8.96	21444206
5-(4-cyano-3-methylphenyl)-2-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)nicotinitrile	Agonist	Agonist	8.77	21939274
compound 36j [PMID:21536438]	Agonist	Agonist	8.52	21536438
compound 58 [PMID:21273063]	Agonist	Agonist	8.4	21273063
AR231453	Agonist	Agonist	8.2	17289847
compound 42 [PMID:22545772]	Agonist	Agonist	8.1	22545772

GPR119 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for GPR119 gene:

NM_178471.2

Unigene Cluster for GPR119:

G protein-coupled receptor 119

Hs.496762 [show with all ESTs]

Unigene Representative Sequence: NM_178471

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000276218(uc011muv.2)

miRNA Products:		Block miRNA regulation of human, mouse, rat GPR119 using miScript Target Protectors
		1 qRT-PCR Assays for microRNA that regulate GPR119:
		hsa-miR-938
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for GPR119
		Predesigned siRNA for gene silencing in human, mouse, rat GPR119

Clone Products:		OriGene clones in human, mouse for GPR119 (see all 5) OriGene ORF clones in mouse, rat for GPR119 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: GPR119 (NM_178471)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for GPR119
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPR119

Primer Products:		OriGene qPCR primer pairs and template standards for GPR119 OriGene qSTAR qPCR primer pairs in human, mouse for GPR119
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat GPR119
		QuantiTect SYBR Green Assays in human, mouse, rat GPR119
		QuantiFast Probe-based Assays in human, mouse, rat GPR119

Additional mRNA sequence:

AY288416.1 BC095502.1 BC101166.1 BC101167.1 BC101168.2 BC126179.1 BC126181.1

1 DOTS entry:

DT.102821017

11 AceView cDNA sequences:

CN837339 CN837348 AY288416 CN836121 NM_178471 CD630065 CN836350 CD630064

CD630063 CN836845 CA841236

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

GPR119 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GCCCTAGGAG

About this image

GPR119 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

GPR119 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.496762

UniProtKB/Swiss-Prot: GP119_HUMAN, Q8TDV5

Tissue specificity: Predominantly expressed in the pancreas, especially in the islets

Pathway & Disease-focused RT² Profiler PCR Array including GPR119:

G Protein Coupled Receptors 384HT in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for GPR119 OriGene qSTAR qPCR primer pairs in human, mouse for GPR119
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat GPR119
		QuantiTect SYBR Green Assays in human, mouse, rat GPR119
		QuantiFast Probe-based Assays in human, mouse, rat GPR119

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR119

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of animals.

Orthologs for GPR119 gene from Selected species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Gpr119^{1 , 5}	G-protein coupled receptor 119^{1, 5}	84.48(n)¹ 82.09(a)¹		X (25.69 cM)⁵ 236781¹ NM_181751.2¹ NP_861416.1¹ 48667979⁵
chicken (Gallus gallus)	Aves	GPR119¹	G protein-coupled receptor 119	62.99(n) 55.52(a)		428690 XM_004940569.1 XP_004940626.1
lizard (Anolis carolinensis)	Reptilia	GPR119⁶	G protein-coupled receptor 119	50(a)	1 ↔ 1	GL343451.1(302855-303847)
zebrafish (Danio rerio)	Actinopterygii	LOC100001479¹	glucose-dependent insulinotropic receptor-like	51.5(n) 44.79(a)		100001479 XM_001337233.5 XP_001337269.1
fruit fly (Drosophila melanogaster)	Insecta	CG12796⁶	--	19(a)	1 ↔ 1	X(6725430-6726717)

ENSEMBL Gene Tree for GPR119 (if available)
TreeFam Gene Tree for GPR119 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

TryGeneCards Plus

Paralogs for GPR119 gene

ADORA1² ADORA2B² ADORA2A²

GPR119 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs189244186^1,2		--	129473965(+)	`GAACAC/TGTAAA`	1	--	ds500¹		0	--	--	--	--
rs73564073^1,2	C,F	--	129474213(+)	`GGGGTG/CGGGGA`	1	--	ds500¹		1		WA	2
rs200006443^1,2	C	--	129474300(+)	`AGTGGA/GGAGGA`	1	--	ut3¹		0	--	--	--	--
rs201648891^1,2	C	--	129474330(+)	`CTCTGC/TCCTTA`	1	--	ut3¹		0	--	--	--	--
rs138209054^1,2	F	--	129474384(+)	`GACAGG/CAACTT`	2	/S /C	mis¹		1		NA	4552
rs5975187^1,2,,4	C,F,H	--	129474423(+)	`TGGCCG/AAGAGA`	2	/S /L	mis¹ ese³ trp³		7		NS EA NA	5072
rs200387439^1,2	C	--	129474568(+)	`CCGTTC/GCAGCA`	2	Q E	mis¹		0	--	--	--	--
rs41310452^1,2	C,F	--	129474643(+)	`GGATAG/CAGCAA`	2	/L /V	mis¹		1		NA	4548
rs200791012^1,2		--	129474714(+)	`ATCGAC/TAACCT`	2	Y C	mis¹		0	--	--	--	--
rs140245947^1,2	C,F	--	129474727(+)	`AGCCAT/CGGCTC`	2	/M /V	mis¹		1		NA	4534

HapMap Linkage Disequilibrium report for GPR119 (129518319 - 129519511 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for GPR119: About this table

Variant ID	Type	Subtype	PubMed ID
nsv528290	CNV	Gain	19592680

Locus Specific Mutation Databases (LSDB): GPR119

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing GPR119

DNA2.0 Custom Variant and Variant Library Synthesis for GPR119

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus

OMIM gene information: 300513 OMIM disorders: --

5 diseases for GPR119:
About MalaCards

cerebritis islet cell tumor obesity diabetes mellitus

pancreatitis

1 disease from the University of Copenhagen DISEASES database for GPR119:

Diabetes mellitus

GPR119 for disorders About GeneDecksing

Export disorders for GPR119 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for GPR119 gene, integrated from 10 sources (see all 21):
(articles sorted by number of sources associating them with GPR119)

Utopia: connect your pdf to the dynamic
world of online information

Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. (PubMed id 14623098)^{1, 2, 3} Fredriksson R....Schioeth H.B. (FEBS Lett. 2003)
Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878)^{1, 2, 3} Takeda S.... Mitaku S. (FEBS Lett. 2002)
Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. (PubMed id 16517404)^{1, 2} Overton H.A.... Reynet C. (Cell Metab. 2006)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{1, 2} Ross M.T.... Bentley D.R. (Nature 2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
GPR119 expression in normal human tissues and islet cell tumors: evidence for its islet-gastrointestinal distribution, expression in pancreatic beta and alpha cells, and involvement in islet function. (PubMed id 22883930)¹ Odori S....Nakao K. (Metab. Clin. Exp. 2013)
GPR119 regulates genetic markers of fatty acid oxidation in cultured skeletal muscle myotubes. (PubMed id 23069642)¹ Cornall L.M....McAinch A.J. (Mol. Cell. Endocrinol. 2013)
Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)¹ Chen Y....Ge F. (amp 2013)
Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (Mol. Cell 2011)
N-oleoyldopamine enhances glucose homeostasis through the activation of GPR119. (PubMed id 19901198)¹ Chu Z.L....Leonard J. (Mol. Endocrinol. 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus

Entrez Gene: 139760	HGNC: 19060	AceView: GPR119	Ensembl:ENSG00000147262	euGenes: HUgn139760
ECgene: GPR119	Kegg: 139760	H-InvDB: GPR119

(According to HUGE)
About This Section

TryGeneCards Plus

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus

Name	Description
PharmGKB entry for GPR119	Pharmacogenomics, SNPs, Pathways

Intellectual Property for GPR119 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

TryGeneCards Plus

Patent Information for GPR119 gene:
Search GeneIP for patents involving GPR119

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus


	EMD Millipore genomic analysis products

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Enzyme Activity Assays/Reagents
	Browse ELISpot/FluoroSpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Luminex Assays
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Recombinant/Natural Proteins		Browse Stem Cell Products
	cDNA Clones for GPR119 (GPR119)		Browse Proteome Profiler Antibody Arrays

	OriGene Antibodies for GPR119		OriGene RNAi products in human, mouse, rat for GPR119
	OriGene qPCR primer pairs and template standards for GPR119		OriGene Protein Over-expression Lysate for GPR119
	OriGene Custom Mass Spec		OriGene clones in human, mouse for GPR119
	OriGene qSTAR qPCR primer pairs in human, mouse for GPR119		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	OriGene ORF clones in mouse, rat for GPR119		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for GPR119		OriGene Custom Protein Services for GPR119

	Block miRNA regulation of human, mouse, rat GPR119 using miScript Target Protectors		SeqTarget long-range PCR primers for resequencing GPR119
	DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GPR119		Predesigned siRNA for gene silencing in human, mouse, rat GPR119
	QuantiFast Probe-based Assays in human, mouse, rat GPR119		QuantiTect SYBR Green Assays in human, mouse, rat GPR119
	PCR Arrays including human, mouse, rat GPR119		Search Chromatin IP Primers for GPR119
	Pre-validated RT² qPCR Primer Assay in human, mouse, rat GPR119		Search GeneGlobe Interaction Network for GPR119
	Regulatory tfbs in GPR119 promoter

	GenScript Custom Purified and Recombinant Proteins Services for GPR119		GenScript cDNA clones with any tag delivered in your preferred vector for GPR119
	GenScript Custom Assay Services for GPR119		GenScript Custom overexpressing Cell Line Services for GPR119
	CloneReady with Over 120,000 Genes		Gene Synthesis: Any Gene in Any Vector
	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

Search for Antibodies & Assays

Tocris compounds for GPR119

	Browse Sino Biological Proteins
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

	Drugs for GPR119
	Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	GPR119 antibodies
	GPR119 proteins
	GPR119 lysates

	Antibodies for GPR119
	See all of Abcam's Antibodies, Kits and Proteins for GPR119
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for GPR119
	Antibodies for GPR119
	ELISAs for GPR119
	CLIAs for GPR119

Browse ESI BIO Cell Lines and PureStem Progenitors for GPR119

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR119

	Browse SwitchGear 3'UTR luciferase reporter plasmids for GPR119
	SwitchGear Promoter luciferase reporter plasmids for GPR119

ThermoFisher Antibodies for GPR119

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPR119

	inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GPR119
	inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GPR119

LSBio Antibodies in human, mouse, rat for GPR119

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

Browse compounds at ApexBio

GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category			(GIFtS: )
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes GPR119 gene at Home site.

Version: 3.12.142 28 July 2014
hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4

GeneCards Plus

Advanced Search

Export list of displayed genes

GPR119 Gene

G Protein-Coupled Receptor 119

Aliases
for GPR119 gene

Summaries
for GPR119 gene

Genomic Views
for GPR119 gene

Proteins
for GPR119 gene

GPR119 Human Recombinant Protein Products:

GPR119 Antibody Products:

GPR119 Assay Products:

Domains /
Families
for GPR119 gene

Function
for GPR119 gene

Localization
for GPR119 gene

Pathways & Interactions
for GPR119 gene

Drugs & Compounds
for GPR119 gene

Transcripts
for GPR119 gene

Expression
for GPR119 gene

Orthologs
for GPR119 gene

Paralogs
for GPR119 gene

Genomic Variants
for GPR119 gene

Disorders / Diseases
for GPR119 gene

Publications
for GPR119 gene

External Searches for GPR119 gene

Genome Databases showing GPR119 gene

Other Databases showing GPR119 gene

Specialized Databases showing GPR119 gene

Intellectual Property
for GPR119 gene

Products
for GPR119 gene

View Random Gene

GeneCards Plus

Advanced Search

Export list of displayed genes

GPR119 Gene

G Protein-Coupled Receptor 119

Aliasesfor GPR119 gene

Summariesfor GPR119 gene

Genomic Viewsfor GPR119 gene

Proteinsfor GPR119 gene

GPR119 Human Recombinant Protein Products:

GPR119 Antibody Products:

GPR119 Assay Products:

Domains /Familiesfor GPR119 gene

Functionfor GPR119 gene

Localizationfor GPR119 gene

Pathways & Interactionsfor GPR119 gene

Drugs & Compoundsfor GPR119 gene

Transcriptsfor GPR119 gene

Expression for GPR119 gene

Orthologsfor GPR119 gene

Paralogsfor GPR119 gene

Genomic Variantsfor GPR119 gene

Disorders / Diseasesfor GPR119 gene

Publicationsfor GPR119 gene

External Searches for GPR119 gene

Genome Databases showing GPR119 gene

Other Databases showing GPR119 gene

Specialized Databases showing GPR119 gene

Intellectual Propertyfor GPR119 gene

Productsfor GPR119 gene

View Random Gene

Aliases
for GPR119 gene

Summaries
for GPR119 gene

Genomic Views
for GPR119 gene

Proteins
for GPR119 gene

Domains /
Families
for GPR119 gene

Function
for GPR119 gene

Localization
for GPR119 gene

Pathways & Interactions
for GPR119 gene

Drugs & Compounds
for GPR119 gene

Transcripts
for GPR119 gene

Expression
for GPR119 gene

Orthologs
for GPR119 gene

Paralogs
for GPR119 gene

Genomic Variants
for GPR119 gene

Disorders / Diseases
for GPR119 gene

Publications
for GPR119 gene

Intellectual Property
for GPR119 gene

Products
for GPR119 gene