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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GPR111 Gene

protein-coding   GIFtS: 44
GCID: GC06P047624

G Protein-Coupled Receptor 111

  Search for GPR111
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
G Protein-Coupled Receptor 1111 2
PGR202 3
hGPCR352
Probable G-Protein Coupled Receptor 1112
G-Protein Coupled Receptor PGR203

External Ids:    HGNC: 189911   Entrez Gene: 2226112   Ensembl: ENSG000001643937   UniProtKB: Q8IZF73   

Export aliases for GPR111 gene to outside databases

Previous GC identifers: GC06P047620 GC06P047671 GC06P047732 GC06P047352


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for GPR111 Gene: 
GPR111 (G protein-coupled receptor 111) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR110.

UniProtKB/Swiss-Prot: GP111_HUMAN, Q8IZF7
Function: Orphan receptor

Gene Wiki entry for GPR111 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GPR111 gene promoter:
         Bach1   AP-1   p53   Bach2   NF-E2 p45   HNF-1A   HEN1   HNF-1   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPR111 promoter sequence
   Search SABiosciences Chromatin IP Primers for GPR111

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPR111


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12.3   Ensembl cytogenetic band:  6p12.3   HGNC cytogenetic band: 6p12.3

GPR111 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPR111 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P047624:  view genomic region     (about GC identifiers)

Start:
47,624,172 bp from pter      End:
47,665,533 bp from pter
Size:
41,362 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GP111_HUMAN, Q8IZF7 (See protein sequence)
Recommended Name: Probable G-protein coupled receptor 111  
Size: 708 amino acids; 78569 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence caution: Sequence=BAC05907.1; Type=Erroneous gene model prediction;
Secondary accessions: Q2PNZ1 Q86SL6 Q8NGU5 Q8TDT5
Alternative splicing: 2 isoforms:  Q8IZF7-1   Q8IZF7-2   

Explore the universe of human proteins at neXtProt for GPR111: NX_Q8IZF7

Explore proteomics data for GPR111 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IZF7

  • GPR111 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GPR111 Protein Expression
    REFSEQ proteins: NP_722581.4  
    ENSEMBL proteins: 
     ENSP00000422934   ENSP00000296862   ENSP00000425269   ENSP00000381727  

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    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    GPR111 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    GPCRBO: GPCR / Class B : Orphans

    IUPHAR Guide to PHARMACOLOGY protein family classification: GPR111 
    Adhesion Class GPCRs

    3 InterPro protein domains:
     IPR000832 GPCR_2_secretin-like
     IPR017981 GPCR_2-like
     IPR000203 GPS_dom

    Graphical View of Domain Structure for InterPro Entry Q8IZF7

    ProtoNet protein and cluster: Q8IZF7

    1 Blocks protein domain: IPB000203 GPS domain

    UniProtKB/Swiss-Prot: GP111_HUMAN, Q8IZF7
    Similarity: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily
    Similarity: Contains 1 GPS domain


    GPR111 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GP111_HUMAN, Q8IZF7
    Function: Orphan receptor

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity ----
    GO:0004930G-protein coupled receptor activity IEA--
         
    GPR111 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Gpr111):
     mortality/aging  reproductive system 

    GPR111 for phenotypes           About GeneDecksing

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GPR111

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway ----
    GO:0007186G-protein coupled receptor signaling pathway TAS15203201
    GO:0007218neuropeptide signaling pathway IEA--

    GPR111 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GPR111 (GP111)

    Search CenterWatch for drugs/clinical trials and news about GPR111 / GP111

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GPR111 gene: 
    NM_153839.6  

    Unigene Cluster for GPR111:

    G protein-coupled receptor 111
    Hs.724860  [show with all ESTs]
    Unigene Representative Sequence: NM_153839
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000507065 ENST00000296862(uc010jzj.1) ENST00000467205(uc003oyy.3)
    ENST00000398742
    miRNA
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    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate GPR111 (see all 18):
    hsa-miR-3678-3p hsa-miR-429 hsa-miR-513a-5p hsa-miR-340 hsa-miR-3921 hsa-miR-29b-1* hsa-miR-149 hsa-miR-3658
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Additional mRNA sequence: 

    AK126683.1 AY140953.1 AY255612.1 

    2 DOTS entries:

    DT.99997755  DT.100060682 

    24/28 AceView cDNA sequences (see all 28):

    AY140953 AY140957 NM_153839 NM_153838 AA126828 AA035119 AY255612 BX112783 
    AA035375 AK095395 BU598648 AY255556 BP336340 BP336304 BX096925 BG696886 
    BU683873 AK126683 AK129826 AI299961 W67511 AA035426 BP335428 AA127310 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GPR111 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCCAGGAAG
    GPR111 Expression
    About this image


    See GPR111 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GPR111

    SOURCE GeneReport for Unigene cluster: Hs.724860
        SABiosciences Expression via Pathway-Focused PCR Array including GPR111: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR111

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for GPR111 gene from 1/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpr1111 , 5 G protein-coupled receptor 1111, 5 78.86(n)1
    75.93(a)1
      17 (19.66 cM)5
    4355291  NM_001033493.21  NP_001028665.21 
     427089365 


    ENSEMBL Gene Tree for GPR111 (if available)
    TreeFam Gene Tree for GPR111 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GPR111 gene
    GPR1102  GPR1152  GPR1282  GPR1162  GPR1132  
    6 SIMAP similar genes for GPR111 using alignment to 2 protein entries:     GP111_HUMAN (see all proteins):
    GPR115    GPCR    GPR110    KPG_009    KPG_008    GPR116

    GPR111 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1175 SNPs in GPR111 are shown (see all 1175)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs348974501,2
    C,F--47536053(+) CAGTGT/GAAATC 1 -- us2k16Minor allele frequency- G:0.33NA WA EA 364
    rs1416322791,2
    --47536057(+) GTAAAA/TCAGAC 1 -- us2k10--------
    rs68999741,2
    C,F,A--47622372(+) CCAGGC/TCAGCC 1 -- us2k17Minor allele frequency- T:0.47WA NA CSA EA 366
    rs68999661,2
    C,F,A,H--47622393(+) CCTCCA/CTTGTT 1 -- us2k113Minor allele frequency- C:0.46NS EA NA WA CSA 756
    rs1140565611,2
    C,F--47622500(+) TTAGGG/AGTCAT 1 -- us2k11Minor allele frequency- A:0.04WA 118
    rs69001821,2
    C,F,A--47622573(+) TGACAA/GTGCGA 1 -- us2k18Minor allele frequency- G:0.47WA NA CSA EA 368
    rs69003341,2
    C,F,A--47622576(+) CAATGC/TGACtg 1 -- us2k18Minor allele frequency- T:0.47WA NA CSA EA 368
    rs1507456541,2
    --47622592(+) GACATA/GTTAGT 1 -- us2k10--------
    rs1161537831,2
    C,F--47622634(+) CTACCG/ACGAGA 1 -- us2k11Minor allele frequency- A:0.03NA 120
    rs1143691381,2
    C,F--47622654(+) TGGGGG/AAGGTT 1 -- us2k11Minor allele frequency- A:0.04WA 118

    HapMap Linkage Disequilibrium report for GPR111 (47624172 - 47665533 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for GPR111:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2369895CNV Deletion18987734
    esv2732042CNV Deletion23290073
    esv2732043CNV Deletion23290073
    esv1092036CNV Deletion17803354
    esv2732041CNV Deletion23290073
    nsv518371CNV Loss19592680
    nsv350137CNV Loss16902084
    esv26618CNV Gain19812545

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GPR111 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with GPR111)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. (PubMed id 12565841)1, 2 Fredriksson R....Schioeth H.B. (2003)
    2. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    3. The G protein-coupled receptor repertoires of human and mouse. (PubMed id 12679517)1, 2 Vassilatis D.K.... Gaitanaris G.A. (2003)
    4. Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878)1, 2 Takeda S.... Mitaku S. (2002)
    5. Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. (PubMed id 12435584)1, 3 Fredriksson R.... Schioeth H.B. (2002)
    6. The human and mouse repertoire of the adhesion family of G-protein- coupled receptors. (PubMed id 15203201)1 Bjarnadottir T.K.... Schioeth H.B. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 222611 HGNC: 18991 AceView: GPR115andGPR111 Ensembl:ENSG00000164393 euGenes: HUgn222611
    ECgene: GPR111 H-InvDB: GPR111

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GPR111 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GPR111 gene:
    Search GeneIP for patents involving GPR111

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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