GPR111 Gene
protein-coding GIFtS: 43
GCID: GC06P047624
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G protein-coupled receptor 111
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Aliases
for GPR111 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| G Protein-Coupled Receptor 1111 2 | | PGR201 2 3 | | HGPCR351 | | G Protein-Coupled Receptor PGR202 | | Probable G-Protein Coupled Receptor 1112 | | G-Protein Coupled Receptor PGR203 |
Export aliases for GPR111 gene to outside databasesPrevious GC identifers: GC06P047620 GC06P047671 GC06P047732 GC06P047352 |
Summaries
for GPR111 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: GP111_HUMAN, Q8IZF7Function: Orphan receptor
Gene Wiki entry for GPR111
|
Genomic Views
for GPR111 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GPR111 gene promoter:
Bach1 AP-1 p53 Bach2 NF-E2 p45 HNF-1A HEN1 HNF-1 NF-E2
Other transcription factors
Search SABiosciences Chromatin IP Primers for GPR111
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPR111 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p12.3 Ensembl cytogenetic band: 6p12.3 HGNC cytogenetic band: 6p12.3GPR111 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P047624: view genomic region
(about GC identifiers)
Start:
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47,624,172 bp from pter |
End:
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47,665,533 bp from pter |
Size:
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41,362 bases |
Orientation:
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plus strand |
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Proteins
for GPR111 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GP111_HUMAN, Q8IZF7 (See
protein sequence)Recommended Name: Probable G-protein coupled receptor 111 Size: 708 amino acids; 78569 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence caution: Sequence=BAC05907.1; Type=Erroneous gene model prediction;
Secondary accessions: Q2PNZ1 Q86SL6 Q8NGU5 Q8TDT5Alternative splicing: 2 isoforms: Q8IZF7-1 Q8IZF7-2 Explore the universe of human proteins at neXtProt for GPR111: NX_Q8IZF7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IZF7
GPR111 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_722581.4
ENSEMBL proteins: ENSP00000422934 ENSP00000296862 ENSP00000425269 ENSP00000381727
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
GPR111 for ontologies About GeneDecksing
GPR111 Antibody Products:
Assay Products for GPR111: |
Protein
Domains /
Families
for GPR111 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GPR111 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IZF7ProtoNet protein and cluster: Q8IZF7 1 Blocks protein family: IPB000203 GPS domain
UniProtKB/Swiss-Prot: GP111_HUMAN, Q8IZF7Similarity: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamilySimilarity: Contains 1 GPS domain |
Function
for GPR111 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: GP111_HUMAN, Q8IZF7Function: Orphan receptor
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPR111
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for GPR111 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPR111 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR111 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
IEA | -- |
GPR111 for ontologies About GeneDecksing
Animal Models:
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Gpr111):
GPR111 for phenotypes About GeneDecksing
|
Pathways & Interactions
for GPR111 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GPR111
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007186 | G-protein coupled receptor signaling pathway |
TAS | 15203201 | | GO:0007218 | neuropeptide signaling pathway |
IEA | -- |
GPR111 for ontologies About GeneDecksing
|
Drugs & Compounds
for GPR111 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for GPR111
Search CenterWatch for drugs/clinical trials and news about GPR111 / GP111
|
Transcripts
for GPR111 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GPR111 gene: NM_153839.6 Unigene Cluster for GPR111: G protein-coupled receptor 111 Hs.724860 [show with all ESTs]Unigene Representative Sequence: NM_1538394 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000507065 ENST00000296862(uc010jzj.1) ENST00000467205(uc003oyy.3)
ENST00000398742
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPR111 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPR111
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: GPR111 (NM_153839) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GPR111 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPR111 |
Additional cDNA sequence: AK126683.1 AY140953.1 AY255612.1 2 DOTS entries: DT.99997755 DT.100060682 24/28 AceView cDNA sequences (see all 28): AY255612 AA126828 AY140953 AK095395 NM_153838 BX112783 NM_153839 AY140957 AA035119 AA035375 BP336304 AY255556 AK126683 BX096925 BU683873 BP336340 BG696886 AI299961 BU598648 AK129826 W67511 AA035426 AA127310 AA058394
GeneLoc Exon Structure
|
Expression
for GPR111 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GPR111 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCCAGGAAG
About this image
See GPR111 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GPR111
SOURCE GeneReport for Unigene cluster: Hs.724860
SABiosciences Expression via Pathway-Focused PCR Array including GPR111: | G Protein Coupled Receptors 384HT in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GPR111
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GPR111 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPR111 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPR111 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR111 |
Orthologs
for GPR111 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for GPR111 gene from 2/13 species (see all 13) About this table
ENSEMBL Gene Tree for GPR111 (if available)
TreeFam Gene Tree for GPR111 (if available) |
Paralogs
for GPR111 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GPR111 gene
- GPR1102 GPR1152 GPR1282 GPR1132 GPR1162
6 SIMAP similar genes for GPR111 using alignment to 2 protein entries: GP111_HUMAN (see all proteins):GPR115 GPCR GPR110 KPG_009 KPG_008 GPR116
GPR111 for paralogs About GeneDecksing
|
Genomic Variants
for GPR111 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GPR111 (47624172 - 47665533 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for GPR111
1 CNV: 69505 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GPR111 |
|
Disorders
/ Diseases
for GPR111 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for GPR111 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GPR111 gene integrated from 9 sources:
(articles sorted by number of sources associating them with GPR111) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. (PubMed id 12565841)1, 2 Fredriksson R....Schioeth H.B. (2003)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- The G protein-coupled receptor repertoires of human and mouse. (PubMed id 12679517)1, 2 Vassilatis D.K.... Gaitanaris G.A. (2003)
- Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878)1, 2 Takeda S.... Mitaku S. (2002)
- Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. (PubMed id 12435584)1, 3 Fredriksson R.... Schioeth H.B. (2002)
- The human and mouse repertoire of the adhesion family of G-protein- coupled receptors. (PubMed id 15203201)1 Bjarnadottir T.K.... Schioeth H.B. (2004)
|
External Searches for GPR111 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GPR111 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GPR111 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GPR111 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GPR111 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for GPR111 gene:
Search GeneIP for patents involving GPR111
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GPR111 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for GPR111 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GPR111 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GPR111 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for GPR111 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPR111 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPR111 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | GPR111 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR111 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPR111 |
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