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Aliases for GPR108 Gene

Aliases for GPR108 Gene

  • G Protein-Coupled Receptor 108 2 3 5
  • Lung Seven Transmembrane Receptor 2 3 4
  • LUSTR2 3 4

External Ids for GPR108 Gene

Previous GeneCards Identifiers for GPR108 Gene

  • GC19M006824
  • GC19M006669
  • GC19M006681
  • GC19M006492

Summaries for GPR108 Gene

GeneCards Summary for GPR108 Gene

GPR108 (G Protein-Coupled Receptor 108) is a Protein Coding gene. An important paralog of this gene is GPR107.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR108 Gene

Genomics for GPR108 Gene

Regulatory Elements for GPR108 Gene

Promoters for GPR108 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPR108 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR108 Gene

Chromosome:
19
Start:
6,729,914 bp from pter
End:
6,737,622 bp from pter
Size:
7,709 bases
Orientation:
Minus strand

Genomic View for GPR108 Gene

Genes around GPR108 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR108 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR108 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR108 Gene

Proteins for GPR108 Gene

  • Protein details for GPR108 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPR9-GP108_HUMAN
    Recommended name:
    Protein GPR108
    Protein Accession:
    Q9NPR9
    Secondary Accessions:
    • B9EJD7

    Protein attributes for GPR108 Gene

    Size:
    543 amino acids
    Molecular mass:
    60633 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR108 Gene

Proteomics data for GPR108 Gene at MOPED

Post-translational modifications for GPR108 Gene

  • Glycosylation at Asn 57, Asn 109, Ser 177, Asn 200, Asn 204, Asn 228, and Asn 534
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPR108 Gene

Domains & Families for GPR108 Gene

Gene Families for GPR108 Gene

Protein Domains for GPR108 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR108 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NPR9

UniProtKB/Swiss-Prot:

GP108_HUMAN :
  • Belongs to the LU7TM family.
Family:
  • Belongs to the LU7TM family.
genes like me logo Genes that share domains with GPR108: view

Function for GPR108 Gene

genes like me logo Genes that share phenotypes with GPR108: view

Animal Model Products

miRNA for GPR108 Gene

miRTarBase miRNAs that target GPR108

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR108 Gene

Localization for GPR108 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR108 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR108 Gene COMPARTMENTS Subcellular localization image for GPR108 gene
Compartment Confidence
golgi apparatus 3
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for GPR108 Gene

Pathways & Interactions for GPR108 Gene

SuperPathways for GPR108 Gene

No Data Available

Interacting Proteins for GPR108 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000264080%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000264080 Q9NPR9-GP108_HUMAN for GPR108 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for GPR108 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GPR108 Gene

Drugs & Compounds for GPR108 Gene

No Compound Related Data Available

Transcripts for GPR108 Gene

Unigene Clusters for GPR108 Gene

G protein-coupled receptor 108:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR108 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a ·
SP1: - - - - - -
SP2: - - -
SP3: - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - - - - - -
SP8: - - - - -
SP9: - -
SP10:
SP11:
SP12: - - -

ExUns: 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11: -
SP12:

Relevant External Links for GPR108 Gene

GeneLoc Exon Structure for
GPR108
ECgene alternative splicing isoforms for
GPR108

Expression for GPR108 Gene

mRNA expression in normal human tissues for GPR108 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR108 Gene

This gene is overexpressed in Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for GPR108 Gene

This gene is overexpressed in Bone marrow stromal cell (51.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR108 Gene



SOURCE GeneReport for Unigene cluster for GPR108 Gene Hs.167641

genes like me logo Genes that share expression patterns with GPR108: view

Protein tissue co-expression partners for GPR108 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GPR108 Gene

Orthologs for GPR108 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPR108 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR108 35
  • 98.36 (n)
  • 98.49 (a)
GPR108 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GPR108 36
  • 81 (a)
OneToOne
GPR108 35
  • 87.11 (n)
  • 85.27 (a)
dog
(Canis familiaris)
Mammalia GPR108 35
  • 87.11 (n)
  • 85.45 (a)
GPR108 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr108 35
  • 82.41 (n)
  • 83.58 (a)
Gpr108 16
Gpr108 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPR108 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr108 35
  • 83.55 (n)
  • 84.47 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12280 35
zebrafish
(Danio rerio)
Actinopterygii GPR108 36
  • 71 (a)
OneToOne
Dr.11789 35
LOC556363 35
  • 61.13 (n)
  • 56.28 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12121 36
  • 30 (a)
OneToMany
CG12121 37
  • 46 (a)
worm
(Caenorhabditis elegans)
Secernentea C15H9.5 37
  • 28 (a)
C15H9.5 36
  • 27 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.4314 35
wheat
(Triticum aestivum)
Liliopsida Ta.9129 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToMany
Species with no ortholog for GPR108:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for GPR108 Gene

ENSEMBL:
Gene Tree for GPR108 (if available)
TreeFam:
Gene Tree for GPR108 (if available)

Paralogs for GPR108 Gene

Paralogs for GPR108 Gene

genes like me logo Genes that share paralogs with GPR108: view

Variants for GPR108 Gene

Sequence variations from dbSNP and Humsavar for GPR108 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_056112 -
VAR_060483 -
rs237555 -- 6,729,599(+) TTCCT(C/G)TGTAG downstream-variant-500B
rs173173 -- 6,731,143(+) TCAGG(A/C/T)GCACC intron-variant
rs339395 -- 6,733,506(+) GAGGC(A/G)CTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR108 Gene

Variant ID Type Subtype PubMed ID
nsv470120 CNV Loss 18288195
dgv3703n71 CNV Loss 21882294
dgv14e196 CNV Duplication 17116639
nsv910940 CNV Loss 21882294
esv2665453 CNV Deletion 23128226
nsv519827 CNV Loss 19592680
nsv910941 CNV Loss 21882294

Variation tolerance for GPR108 Gene

Residual Variation Intolerance Score: 93.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.79; 58.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR108 Gene

HapMap Linkage Disequilibrium report
GPR108

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR108 Gene

Disorders for GPR108 Gene

Relevant External Links for GPR108

Genetic Association Database (GAD)
GPR108
Human Genome Epidemiology (HuGE) Navigator
GPR108
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR108

No disorders were found for GPR108 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR108 Gene

Publications for GPR108 Gene

  1. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S. … Kang D. (Hum. Immunol. 2010) 3 48 67
  2. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P. … Inskip P.D. (Cancer Epidemiol. Biomarkers Prev. 2010) 3
  3. Common variation in genes related to innate immunity and risk of adult glioma. (PMID: 19423540) Rajaraman P. … Chanock S.J. (Cancer Epidemiol. Biomarkers Prev. 2009) 3
  4. Human GPR107 and murine Gpr108 are members of the LUSTR family of proteins found in both plants and animals, having similar topology to G-protein coupled receptors. (PMID: 17454009) Edgar A.J. (DNA Seq. 2007) 3
  5. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3

Products for GPR108 Gene

Sources for GPR108 Gene

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