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Aliases for GPR108 Gene

Aliases for GPR108 Gene

  • G Protein-Coupled Receptor 108 2 3 5
  • Lung Seven Transmembrane Receptor 2 3 4
  • LUSTR2 3 4
  • Protein GPR108 3

External Ids for GPR108 Gene

Previous GeneCards Identifiers for GPR108 Gene

  • GC19M006824
  • GC19M006669
  • GC19M006681
  • GC19M006492

Summaries for GPR108 Gene

GeneCards Summary for GPR108 Gene

GPR108 (G Protein-Coupled Receptor 108) is a Protein Coding gene. An important paralog of this gene is GPR107.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR108 Gene

Genomics for GPR108 Gene

Regulatory Elements for GPR108 Gene

Enhancers for GPR108 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around GPR108 on UCSC Golden Path with GeneCards custom track

Promoters for GPR108 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for GPR108 Gene

6,729,914 bp from pter
6,737,622 bp from pter
7,709 bases
Minus strand

Genomic View for GPR108 Gene

Genes around GPR108 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR108 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR108 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR108 Gene

Proteins for GPR108 Gene

  • Protein details for GPR108 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein GPR108
    Protein Accession:
    Secondary Accessions:
    • B9EJD7

    Protein attributes for GPR108 Gene

    543 amino acids
    Molecular mass:
    60633 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR108 Gene

Post-translational modifications for GPR108 Gene

  • Glycosylation at Asn 57, Asn 109, Ser 177, Asn 200, Asn 204, Asn 228, and Asn 534
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPR108 Gene

Domains & Families for GPR108 Gene

Gene Families for GPR108 Gene

Protein Domains for GPR108 Gene


Suggested Antigen Peptide Sequences for GPR108 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the LU7TM family.
  • Belongs to the LU7TM family.
genes like me logo Genes that share domains with GPR108: view

Function for GPR108 Gene

genes like me logo Genes that share phenotypes with GPR108: view

Animal Model Products

CRISPR Products

miRNA for GPR108 Gene

miRTarBase miRNAs that target GPR108

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR108 Gene

Localization for GPR108 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR108 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GPR108 Gene COMPARTMENTS Subcellular localization image for GPR108 gene
Compartment Confidence
golgi apparatus 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for GPR108 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR108: view

Pathways & Interactions for GPR108 Gene

SuperPathways for GPR108 Gene

No Data Available

Interacting Proteins for GPR108 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000264080 Q9NPR9-GP108_HUMAN for GPR108 Gene via STRING IID

Gene Ontology (GO) - Biological Process for GPR108 Gene


No data available for Pathways by source and SIGNOR curated interactions for GPR108 Gene

Drugs & Compounds for GPR108 Gene

No Compound Related Data Available

Transcripts for GPR108 Gene

Unigene Clusters for GPR108 Gene

G protein-coupled receptor 108:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR108 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a ·
SP1: - - - - - -
SP2: - - -
SP3: - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - - - - - -
SP8: - - - - -
SP9: - -
SP12: - - -

ExUns: 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20
SP10: -
SP11: -

Relevant External Links for GPR108 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR108 Gene

mRNA expression in normal human tissues for GPR108 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR108 Gene

This gene is overexpressed in Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for GPR108 Gene

This gene is overexpressed in Bone marrow stromal cell (51.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR108 Gene

Protein tissue co-expression partners for GPR108 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPR108 Gene:


SOURCE GeneReport for Unigene cluster for GPR108 Gene:

genes like me logo Genes that share expression patterns with GPR108: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for GPR108 Gene

Orthologs for GPR108 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPR108 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPR108 34
  • 87.11 (n)
  • 85.27 (a)
GPR108 35
  • 81 (a)
(Canis familiaris)
Mammalia GPR108 34
  • 87.11 (n)
  • 85.45 (a)
GPR108 35
  • 84 (a)
(Mus musculus)
Mammalia Gpr108 34
  • 82.41 (n)
  • 83.58 (a)
Gpr108 16
Gpr108 35
  • 79 (a)
(Pan troglodytes)
Mammalia GPR108 34
  • 98.36 (n)
  • 98.49 (a)
GPR108 35
  • 97 (a)
(Rattus norvegicus)
Mammalia Gpr108 34
  • 83.55 (n)
  • 84.47 (a)
(Monodelphis domestica)
Mammalia GPR108 35
  • 76 (a)
(Danio rerio)
Actinopterygii Dr.11789 34
LOC556363 34
  • 61.13 (n)
  • 56.28 (a)
GPR108 35
  • 71 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12280 34
fruit fly
(Drosophila melanogaster)
Insecta CG12121 36
  • 46 (a)
CG12121 35
  • 30 (a)
(Caenorhabditis elegans)
Secernentea C15H9.5 36
  • 28 (a)
C15H9.5 35
  • 27 (a)
(Oryza sativa)
Liliopsida Os.4314 34
(Triticum aestivum)
Liliopsida Ta.9129 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 48 (a)
Species where no ortholog for GPR108 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for GPR108 Gene

Gene Tree for GPR108 (if available)
Gene Tree for GPR108 (if available)

Paralogs for GPR108 Gene

Paralogs for GPR108 Gene

genes like me logo Genes that share paralogs with GPR108: view

Variants for GPR108 Gene

Sequence variations from dbSNP and Humsavar for GPR108 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_056112 -
VAR_060483 -
rs11539588 -- 6,735,918(-) AGTTC(A/C/G/T)CTCCT reference, missense, utr-variant-5-prime
rs11539590 -- 6,733,913(-) TTCAG(C/G)GTCCT reference, missense, utr-variant-5-prime
rs77822830 -- 6,734,247(+) GCTTC(C/G/T)GGGAG reference, synonymous-codon, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for GPR108 Gene

Variant ID Type Subtype PubMed ID
dgv14e196 CNV duplication 17116639
esv2665453 CNV deletion 23128226
nsv470120 CNV loss 18288195
nsv519827 CNV loss 19592680
nsv953955 CNV deletion 24416366

Variation tolerance for GPR108 Gene

Residual Variation Intolerance Score: 93.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.79; 58.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR108 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR108 Gene

Disorders for GPR108 Gene

Relevant External Links for GPR108

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GPR108 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR108 Gene

Publications for GPR108 Gene

  1. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P. … Inskip P.D. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 46 65
  2. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S. … Kang D. (Hum. Immunol. 2010) 3 46 65
  3. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 65
  4. Common variation in genes related to innate immunity and risk of adult glioma. (PMID: 19423540) Rajaraman P. … Chanock S.J. (Cancer Epidemiol. Biomarkers Prev. 2009) 3 65
  5. Human GPR107 and murine Gpr108 are members of the LUSTR family of proteins found in both plants and animals, having similar topology to G-protein coupled receptors. (PMID: 17454009) Edgar A.J. (DNA Seq. 2007) 3 65

Products for GPR108 Gene

Sources for GPR108 Gene

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