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Aliases for GPR107 Gene

Aliases for GPR107 Gene

  • G Protein-Coupled Receptor 107 2 3 5
  • Lung Seven Transmembrane Receptor 1 3 4
  • LUSTR1 3 4
  • Protein GPR107 3
  • BA138E2.2 3
  • KIAA1624 4
  • GCDRP 3

External Ids for GPR107 Gene

Previous GeneCards Identifiers for GPR107 Gene

  • GC09P123930
  • GC09P124462
  • GC09P126269
  • GC09P128192
  • GC09P129895
  • GC09P131855
  • GC09P132815
  • GC09P102415

Summaries for GPR107 Gene

GeneCards Summary for GPR107 Gene

GPR107 (G Protein-Coupled Receptor 107) is a Protein Coding gene. An important paralog of this gene is GPR108.

UniProtKB/Swiss-Prot for GPR107 Gene

  • Involved in Golgi-to-ER retrograde transport. Functions as a host factor required for infection by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT toxins.

Gene Wiki entry for GPR107 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR107 Gene

Genomics for GPR107 Gene

Regulatory Elements for GPR107 Gene

Enhancers for GPR107 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G130136 1.4 Ensembl ENCODE dbSUPER 7 +84.9 84945 3.3 HDGF PKNOX1 ATF1 ARNT ARID4B ZNF2 CBX5 ZNF143 FOS ZNF263 NCS1 GPR107 C9orf50 PIR32024 LOC401554
GH09G129954 1.5 Ensembl ENCODE dbSUPER 5.1 -97.4 -97378 3.1 HDGF ARNT WRNIP1 TCF12 KLF7 NCOA1 JUNB TBX21 SMARCB1 MAFF FNBP1 TOR1A TOR1B ENSG00000230684 USP20 C9orf78 GPR107
GH09G129605 1.9 FANTOM5 ENCODE dbSUPER 1.2 -444.5 -444544 5.8 CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 MCM3 TBX21 LOC101929314 SPOUT1 PKN3 NCS1 USP20 ENSG00000234055 ASB6 NTMT1 C9orf50 IER5L
GH09G130051 1.7 FANTOM5 ENCODE dbSUPER 0.7 -0.1 -86 3.5 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ZNF143 ZNF207 TOR1A ENSG00000230684 C9orf78 USP20 TOR1B GPR107 GC09M130044
GH09G130061 1.2 Ensembl ENCODE dbSUPER 0.4 +8.3 8328 1.0 CTCF PKNOX1 NR2F1 RAD21 GABPB1 IKZF1 RELB MLLT1 IKZF2 ZNF652 ENSG00000230684 GPR107 PIR52550
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPR107 on UCSC Golden Path with GeneCards custom track

Promoters for GPR107 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000242146 574 1601 CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ZNF143 ZNF207 SP3

Genomic Location for GPR107 Gene

Chromosome:
9
Start:
130,053,426 bp from pter
End:
130,140,169 bp from pter
Size:
86,744 bases
Orientation:
Plus strand

Genomic View for GPR107 Gene

Genes around GPR107 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR107 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR107 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR107 Gene

Proteins for GPR107 Gene

  • Protein details for GPR107 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VW38-GP107_HUMAN
    Recommended name:
    Protein GPR107
    Protein Accession:
    Q5VW38
    Secondary Accessions:
    • A6NJ53
    • Q2TB81
    • Q5JPA3
    • Q5VW39
    • Q96T26
    • Q9H658
    • Q9HCE8

    Protein attributes for GPR107 Gene

    Size:
    600 amino acids
    Molecular mass:
    66990 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GPR107 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPR107 Gene

Post-translational modifications for GPR107 Gene

  • Cleaved by a furin endopeptidase to yield two fragments of 17 and 35 kDa that remain associated via a disulfide bond.
  • Glycosylation at isoforms=2, 370, isoforms=2, 3169, and posLast=211211
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPR107 Gene

Domains & Families for GPR107 Gene

Gene Families for GPR107 Gene

Protein Domains for GPR107 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR107 Gene

Graphical View of Domain Structure for InterPro Entry

Q5VW38

UniProtKB/Swiss-Prot:

GP107_HUMAN :
  • Belongs to the LU7TM family.
Family:
  • Belongs to the LU7TM family.
genes like me logo Genes that share domains with GPR107: view

Function for GPR107 Gene

Molecular function for GPR107 Gene

UniProtKB/Swiss-Prot Function:
Involved in Golgi-to-ER retrograde transport. Functions as a host factor required for infection by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT toxins.

Gene Ontology (GO) - Molecular Function for GPR107 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032050 clathrin heavy chain binding IEA --
genes like me logo Genes that share ontologies with GPR107: view
genes like me logo Genes that share phenotypes with GPR107: view

Animal Models for GPR107 Gene

MGI Knock Outs for GPR107:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR107

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR107 Gene

Localization for GPR107 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR107 Gene

Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR107 gene
Compartment Confidence
nucleus 5
golgi apparatus 5
plasma membrane 3
endosome 2

Gene Ontology (GO) - Cellular Components for GPR107 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005769 early endosome IEA --
GO:0005794 Golgi apparatus IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR107: view

Pathways & Interactions for GPR107 Gene

SuperPathways for GPR107 Gene

No Data Available

Interacting Proteins for GPR107 Gene

Gene Ontology (GO) - Biological Process for GPR107 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0072583 clathrin-dependent endocytosis IEA --
genes like me logo Genes that share ontologies with GPR107: view

No data available for Pathways by source and SIGNOR curated interactions for GPR107 Gene

Drugs & Compounds for GPR107 Gene

No Compound Related Data Available

Transcripts for GPR107 Gene

Unigene Clusters for GPR107 Gene

G protein-coupled receptor 107:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR107 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^
SP1: - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - - -
SP5:
SP6:
SP7: -

ExUns: 21a · 21b · 21c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for GPR107 Gene

GeneLoc Exon Structure for
GPR107
ECgene alternative splicing isoforms for
GPR107

Expression for GPR107 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR107 Gene

Protein differential expression in normal tissues from HIPED for GPR107 Gene

This gene is overexpressed in Nasal epithelium (55.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GPR107 Gene



NURSA nuclear receptor signaling pathways regulating expression of GPR107 Gene:

GPR107

SOURCE GeneReport for Unigene cluster for GPR107 Gene:

Hs.512461

Evidence on tissue expression from TISSUES for GPR107 Gene

  • Nervous system(4.9)
  • Intestine(4.4)
  • Lymph node(4.2)
  • Lung(2.2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with GPR107: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR107 Gene

Orthologs for GPR107 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPR107 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR107 34 35
  • 99.82 (n)
cow
(Bos Taurus)
Mammalia GPR107 34 35
  • 89.53 (n)
dog
(Canis familiaris)
Mammalia GPR107 34 35
  • 89.22 (n)
mouse
(Mus musculus)
Mammalia Gpr107 34 16 35
  • 83.4 (n)
rat
(Rattus norvegicus)
Mammalia Gpr107 34
  • 82.75 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR107 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR107 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR107 34 35
  • 74.58 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr107 34
  • 66.73 (n)
zebrafish
(Danio rerio)
Actinopterygii gpr107 34 35
  • 66.47 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12121 34 35
  • 55.23 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000913 34
  • 54.99 (n)
worm
(Caenorhabditis elegans)
Secernentea C15H9.5 34 35
  • 45.58 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G42090 34
  • 51.88 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.380 34
rice
(Oryza sativa)
Liliopsida Os06g0132100 34
  • 49.68 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 54 (a)
OneToMany
Species where no ortholog for GPR107 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPR107 Gene

ENSEMBL:
Gene Tree for GPR107 (if available)
TreeFam:
Gene Tree for GPR107 (if available)

Paralogs for GPR107 Gene

Paralogs for GPR107 Gene

(1) SIMAP similar genes for GPR107 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GPR107: view

Variants for GPR107 Gene

Sequence variations from dbSNP and Humsavar for GPR107 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000014147 -- 130,085,167(+) AGGGT(A/G)GCCTT intron-variant
rs1000024941 -- 130,052,890(+) CGGGA(A/G)GATAA intron-variant, upstream-variant-2KB
rs1000059841 -- 130,131,746(+) CCCTC(C/T)TCCTC intron-variant
rs1000132430 -- 130,054,622(+) TGTGT(A/C)TCTAA intron-variant, upstream-variant-2KB
rs1000141742 -- 130,103,307(+) AATAA(C/T)AGCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR107 Gene

Variant ID Type Subtype PubMed ID
esv2664800 CNV deletion 23128226
esv3621853 CNV gain 21293372
esv3621854 CNV loss 21293372
nsv1046307 CNV gain 25217958
nsv1141030 CNV deletion 24896259
nsv1141031 CNV deletion 24896259
nsv1153370 CNV insertion 26484159
nsv466590 CNV gain 19166990
nsv474774 CNV novel sequence insertion 20440878
nsv518603 CNV loss 19592680
nsv615498 CNV gain 21841781
nsv6730 CNV insertion 18451855
nsv6732 CNV deletion 18451855
nsv831732 CNV loss 17160897
nsv831733 CNV loss 17160897

Variation tolerance for GPR107 Gene

Residual Variation Intolerance Score: 22.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.71; 46.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR107 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR107

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR107 Gene

Disorders for GPR107 Gene

Relevant External Links for GPR107

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR107

No disorders were found for GPR107 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR107 Gene

Publications for GPR107 Gene

  1. GPR107, a G-protein-coupled receptor essential for intoxication by Pseudomonas aeruginosa exotoxin A, localizes to the Golgi and is cleaved by furin. (PMID: 25031321) Tafesse F.G. … Ploegh H.L. (J. Biol. Chem. 2014) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
  4. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 3 4 64
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64

Products for GPR107 Gene

Sources for GPR107 Gene

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