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GPR107 Gene

protein-coding   GIFtS: 50
GCID: GC09P132815

G Protein-Coupled Receptor 107

  Search for GPR107
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
G Protein-Coupled Receptor 1071 2     bA138E2.22
Lung Seven Transmembrane Receptor 12 3     Protein GPR1072
LUSTR12 3     KIAA16243
GCDRP2     

External Ids:    HGNC: 178301   Entrez Gene: 577202   Ensembl: ENSG000001483587   UniProtKB: Q5VW383   

Export aliases for GPR107 gene to outside databases

Previous GC identifers: GC09P123930 GC09P124462 GC09P126269 GC09P128192 GC09P129895 GC09P131855 GC09P102415


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for GPR107 Gene:
GPR107 (G protein-coupled receptor 107) is a protein-coding gene. An important paralog of this gene is GPR108.

Gene Wiki entry for GPR107 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GPR107 gene promoter:
         SRF   SRF (504 AA)   C/EBPalpha   Max   PPAR-gamma1   POU2F1   POU2F1a   PPAR-gamma2   c-Myc   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPR107 promoter sequence
   Search Chromatin IP Primers for GPR107

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GPR107


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.11   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34.2

GPR107 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPR107 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P132815:  view genomic region     (about GC identifiers)

Start:
132,815,705 bp from pter      End:
132,902,448 bp from pter
Size:
86,744 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GP107_HUMAN, Q5VW38 (See protein sequence)
Recommended Name: Protein GPR107 precursor  
Size: 600 amino acids; 66990 Da
Secondary accessions: A6NJ53 Q2TB81 Q5JPA3 Q5VW39 Q96T26 Q9H658 Q9HCE8
Alternative splicing: 3 isoforms:  Q5VW38-1   Q5VW38-2   Q5VW38-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GPR107: NX_Q5VW38

Explore proteomics data for GPR107 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn70, Ser157, Ser166, Asn169, Thr171, Asn211
  • Modification sites at PhosphoSitePlus

  • See GPR107 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001130029.1  NP_001130030.1  NP_001274275.1  NP_066011.2  

    ENSEMBL proteins: 
     ENSP00000361483   ENSP00000336988   ENSP00000475772   ENSP00000361487  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    O7TM: GPCR / Unclassified : 7TM orphan receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: GPR107
    Other 7TM proteins

    1 InterPro protein domain:
     IPR009637 TM_rcpt_euk

    Graphical View of Domain Structure for InterPro Entry Q5VW38

    ProtoNet protein and cluster: Q5VW38

    UniProtKB/Swiss-Prot: GP107_HUMAN, Q5VW38
    Similarity: Belongs to the LU7TM family


    Find genes that share domains with GPR107           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for GPR107:
     Decreased TP53 protein express 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Gpr107):
     mortality/aging 

    Find genes that share phenotypes with GPR107           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GPR107
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GPR107
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    hsa-mir-221-3p (MIRT024176), hsa-mir-26b-5p (MIRT029572)

    Block miRNA regulation of human, mouse, rat GPR107 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GPR107 (see all 30):
    hsa-miR-320a hsa-miR-498 hsa-miR-140-5p hsa-miR-125a-5p hsa-miR-429 hsa-miR-2110 hsa-miR-767-5p hsa-miR-1258
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GP107_HUMAN, Q5VW38: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with GPR107           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GPR107
    Interactions:

        Search GeneGlobe Interaction Network for GPR107

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for GPR107 (ENSP000003614834) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0019236response to pheromone ----

    Find genes that share ontologies with GPR107           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GPR107 (GP107)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GPR107 gene (4 alternative transcripts): 
    NM_001136557.1  NM_001136558.1  NM_001287346.1  NM_020960.4  

    Unigene Cluster for GPR107:

    G protein-coupled receptor 107
    Hs.512461  [show with all ESTs]
    Unigene Representative Sequence: NM_001136557
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372406(uc004bze.2) ENST00000347136 ENST00000493417(uc004bzb.2)
    ENST00000462907 ENST00000483935 ENST00000415344 ENST00000372410(uc004bzg.1 uc011mbx.1 uc004bzd.2)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate GPR107 (see all 30):
    hsa-miR-320a hsa-miR-498 hsa-miR-140-5p hsa-miR-125a-5p hsa-miR-429 hsa-miR-2110 hsa-miR-767-5p hsa-miR-1258
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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      QuantiTect SYBR Green Assays in human, mouse, rat GPR107
      QuantiFast Probe-based Assays in human, mouse, rat GPR107

    Additional mRNA sequence: 

    AB046844.1 AF308603.1 AF376725.1 AJ420422.1 AJ420428.1 AK000825.1 AK021506.1 AK024651.1 
    AK025836.1 AK074380.1 AK131317.1 AK225456.1 AK293092.1 AL834359.1 BC007544.1 BC030147.2 
    BC039728.1 BC040059.2 BC110518.2 BC143655.1 

    24 DOTS entries:

    DT.40120021  DT.100044675  DT.97864282  DT.95091643  DT.435785  DT.451679  DT.91652871  DT.95149652 
    DT.100696538  DT.102829156  DT.40248623  DT.403075  DT.91685267  DT.92048449  DT.95219567  DT.100780462 
    DT.121170120  DT.121170212  DT.40222107  DT.92407843  DT.95295915  DT.121170191  DT.91722404  DT.95084667 

    Selected AceView cDNA sequences (see all 434):

    AW316535 BU542697 BU543265 BU552423 AA707185 BU543490 BM682984 AX776003 
    BU541903 BU736229 AI802509 BQ936788 AI000727 AU121102 BM550437 BF513929 
    AI674382 BF434145 N79512 AK026244 BX420522 BU543206 BM666357 BE260294 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GPR107 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^
    SP1:                          -           -                                                                                                           -     -   
    SP2:                          -           -                                                                             -     -                       -     -   
    SP3:                          -           -                                                                             -     -                                 
    SP4:                          -           -                                   -     -     -                                                                     
    SP5:                                                                                                                                                            

    ExUns: 21a · 21b · 21c
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for GPR107

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GPR107 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGATGTACG
    GPR107 Expression
    About this image

    GPR107 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GPR107 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.512461
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR107

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GPR107 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpr1071 , 5 G protein-coupled receptor 1071, 5 83.4(n)1
    87.45(a)1
      2 (21.80 cM)5
    2774631  NM_178760.41  NP_848875.21 
     311523165 
    chicken
    (Gallus gallus)
    Aves GPR1071 G protein-coupled receptor 107 74.58(n)
    79.38(a)
      417186  NM_001030686.1  NP_001025857.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia gpr1071 G protein-coupled receptor 107 66.73(n)
    70.55(a)
      100145477  NM_001126929.1  NP_001120401.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CA474283.12   -- 74.14(n)    CA474283.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG121211 CG12121 55.23(n)
    50.98(a)
      31866  NM_132317.1  NP_572545.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C15H9.51 C15H9.5 45.58(n)
    35.68(a)
      180881  NM_076619.3  NP_509020.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G420901 AT5G42090 51.88(n)
    44.05(a)
      834214  NM_123574.2  NP_199024.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g01321001 Os06g0132100 49.68(n)
    42.31(a)
      4340012  NM_001063233.1  NP_001056698.1 


    ENSEMBL Gene Tree for GPR107 (if available)
    TreeFam Gene Tree for GPR107 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GPR107 gene
    GPR1082  
    1 SIMAP similar gene for GPR107 using alignment to 4 protein entries:     GP107_HUMAN (see all proteins):
    GPR108

    Find genes that share paralogs with GPR107           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GPR107 (see all 2008)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1478141241,2
    --132814132(+) GACTAA/GGAGAG 3 -- us2k10--------
    rs48366861,2
    C,F,H--132814215(+) TGTAAC/TGTCCC 3 -- us2k119Minor allele frequency- T:0.03NS EA NA WA CSA 937
    rs1890487321,2
    --132814216(+) GTAATC/GTCCCT 3 -- us2k10--------
    rs1809588351,2
    --132814320(+) TTCTTC/GAAACT 3 -- us2k10--------
    rs1399853681,2
    --132814462(+) ATAATG/TACTGG 3 -- us2k10--------
    rs1454205381,2
    C--132814563(+) GATAAA/TACCCA 3 -- us2k10--------
    rs801765441,2
    F--132814625(+) CTGTTG/CTCCAG 3 -- us2k11Minor allele frequency- C:0.05WA 118
    rs1476716281,2
    C--132814858(+) AGGCGC/TGCGGC 3 -- us2k10--------
    rs1860881461,2
    --132814900(+) TAGAGA/GCGAGG 3 -- us2k10--------
    rs2005159651,2
    C--132814906(+) CGAGG-/TTTTGC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for GPR107 (132815705 - 132902448 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for GPR107:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2664800CNV Deletion23128226
    nsv6730CNV Insertion18451855
    nsv6732CNV Loss18451855
    nsv831733CNV Loss17160897
    nsv831732CNV Loss17160897
    nsv518603CNV Loss19592680
    nsv466590CNV Gain19166990
    nsv893931CNV Gain+Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GPR107
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GPR107 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with GPR107)
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    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    3. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    4. Evidence for an interaction of neuronostatin with the orphan G protein-coupled receptor, GPR107. (PubMed id 22933024)1 Yosten G.L....Samson W.K. (Am. J. Physiol. Regul. Integr. Comp. Physiol. 2012)
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. Human GPR107 and murine Gpr108 are members of the LUSTR family of proteins found in both plants and animals, having similar topology to G-protein coupled receptors. (PubMed id 17454009)1 Edgar A.J. (DNA Seq. 2007)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57720 HGNC: 17830 AceView: GPR107 Ensembl:ENSG00000148358 euGenes: HUgn57720
    ECgene: GPR107 H-InvDB: GPR107

    (According to HUGE)
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    HUGE: KIAA1624

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GPR107 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GPR107 gene:
    Search GeneIP for patents involving GPR107

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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