GPR107 Gene
protein-coding GIFtS: 47
GCID: GC09P132815
|
|
G protein-coupled receptor 107
| |
Aliases
for GPR107 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| G Protein-Coupled Receptor 1071 2 | | FLJ209981 | | LUSTR11 2 3 | | GCDRP2 | | RP11-88G171 2 | | BA138E2.21 | | KIAA16241 3 | | Protein GPR1072 | | Lung Seven Transmembrane Receptor 12 3 | | |
Export aliases for GPR107 gene to outside databasesPrevious GC identifers: GC09P123930 GC09P124462 GC09P126269 GC09P128192 GC09P129895 GC09P131855 GC09P102415 |
Summaries
for GPR107 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for GPR107
|
Genomic Views
for GPR107 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GPR107 gene promoter:
SRF SRF (504 AA) C/EBPalpha Max PPAR-gamma1 POU2F1 POU2F1a PPAR-gamma2 c-Myc Hlf
Other transcription factors
Search SABiosciences Chromatin IP Primers for GPR107
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPR107 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.11 Ensembl cytogenetic band: 9q34.11 HGNC cytogenetic band: 9q34.2GPR107 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P132815: view genomic region
(about GC identifiers)
Start:
|
132,815,705 bp from pter |
End:
|
132,902,448 bp from pter |
Size:
|
86,744 bases |
Orientation:
|
plus strand |
|
Proteins
for GPR107 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GP107_HUMAN, Q5VW38 (See
protein sequence)Recommended Name: Protein GPR107 precursor Size: 600 amino acids; 66990 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: A6NJ53 Q2TB81 Q5JPA3 Q5VW39 Q96T26 Q9H658 Q9HCE8Alternative splicing: 3 isoforms: Q5VW38-1 Q5VW38-2 Q5VW38-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for GPR107: NX_Q5VW38
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5VW38
GPR107 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001130029.1 NP_001130030.1 NP_066011.2
ENSEMBL proteins: ENSP00000361483 ENSP00000434789 ENSP00000336988 ENSP00000361487
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
GPR107 for ontologies About GeneDecksing
GPR107 Antibody Products:
Assay Products for GPR107: |
Protein
Domains /
Families
for GPR107 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GPR107 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5VW38ProtoNet protein and cluster: Q5VW38 UniProtKB/Swiss-Prot: GP107_HUMAN, Q5VW38Similarity: Belongs to the LU7TM family |
Function
for GPR107 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPR107 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPR107 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): GPR107 (NM_020960) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GPR107 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPR107 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR107 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004872 | receptor activity |
-- | -- |
GPR107 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for GPR107:
|
Pathways & Interactions
for GPR107 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GPR107
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for GPR107 (ENSP000003614834) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for GPR107 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for GPR107
Search CenterWatch for drugs/clinical trials and news about GPR107 / GP107
|
Transcripts
for GPR107 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GPR107 gene (3 alternative transcripts): NM_001136557.1 NM_001136558.1 NM_020960.4 Unigene Cluster for GPR107: G protein-coupled receptor 107 Hs.512461 [show with all ESTs]Unigene Representative Sequence: NM_0011365577 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372406(uc004bze.2) ENST00000475101 ENST00000347136 ENST00000493417(uc004bzb.2)
ENST00000462907 ENST00000483935 ENST00000372410(uc004bzg.1 uc011mbx.1 uc004bzd.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPR107 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPR107 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): GPR107 (NM_020960) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GPR107 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPR107 |
Additional cDNA sequence: AB046844.1 AF308603.1 AF376725.1 AJ420422.1 AJ420428.1 AK000825.1 AK021506.1 AK024651.1 AK025836.1 AK074380.1 AK131317.1 AK225456.1 AK293092.1 AL834359.1 BC007544.1 BC030147.2 BC039728.1 BC040059.2 BC110518.2 BC143655.1 24 DOTS entries: DT.40120021 DT.100044675 DT.97864282 DT.95091643 DT.435785 DT.451679 DT.91652871 DT.95149652 DT.100696538 DT.102829156 DT.40248623 DT.403075 DT.91685267 DT.92048449 DT.95219567 DT.100780462 DT.121170120 DT.121170212 DT.40222107 DT.92407843 DT.95295915 DT.121170191 DT.91722404 DT.95084667 24/434 AceView cDNA sequences (see all 434): AB046844 AI924896 BU844524 AW316609 BQ937332 AI364057 BU553856 NM_020960 BX101344 AI125153 BM850758 AW451329 AW472889 BE293611 AX776003 AA903757 T16533 BM695179 BQ952855 AI922858 BG925290 AA707185 BU541903 BM856689
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for GPR107 (see all 7) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ |
|---|
|
| SP1: | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | |
| SP2: | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | - | | - | | |
| SP3: | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | - | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 21a | · | 21b | · | 21c |
|---|
|
| SP1: | | | | | | | |
| SP2: | | | | | | | |
| SP3: | | | | | | | |
| SP4: | | | | | | | |
| SP5: | | | | | | |
ECgene alternative splicing isoforms for GPR107
|
Expression
for GPR107 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GPR107 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGATGTACG
About this image
See GPR107 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GPR107
SOURCE GeneReport for Unigene cluster: Hs.512461
SABiosciences Custom PCR Arrays for GPR107
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GPR107
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GPR107 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPR107 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPR107 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR107 |
Orthologs
for GPR107 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for GPR107 gene from 6/24 species (see all 24) About this table
ENSEMBL Gene Tree for GPR107 (if available)
TreeFam Gene Tree for GPR107 (if available) |
Paralogs
for GPR107 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GPR107 gene
- GPR1082
1 SIMAP similar gene for GPR107 using alignment to 3 protein entries: GP107_HUMAN (see all proteins):GPR108
GPR107 for paralogs About GeneDecksing
|
Genomic Variants
for GPR107 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GPR107 (132815705 - 132902448 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for GPR107
1 Indel: 41207 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GPR107 |
|
Disorders
/ Diseases
for GPR107 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GPR107 for disorders About GeneDecksing
6  diseases for GPR107: About MalaCardsnail-patella syndrome focal dermal hypoplasia nevoid basal cell carcinoma syndrome spina bifida
basal cell carcinoma carcinoma
Export disorders for GPR107 gene to outside databases
|
Publications
for GPR107 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GPR107 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with GPR107) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2 Nagase T.... Ohara O. (2000)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Human GPR107 and murine Gpr108 are members of the LUSTR family of proteins found in both plants and animals, having similar topology to G-protein coupled receptors. (PubMed id 17454009)1 Edgar A.J. (2007)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for GPR107 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GPR107 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GPR107 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing GPR107 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GPR107 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for GPR107 gene:
Search GeneIP for patents involving GPR107
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GPR107 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for GPR107 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GPR107 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GPR107 | | | OriGene Protein Over-expression Lysate for GPR107 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for GPR107 | | OriGene 3'-UTR Clone for GPR107 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPR107 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPR107 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR107 |
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