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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GPR107 Gene

protein-coding   GIFtS: 49
GCID: GC09P132815

G Protein-Coupled Receptor 107

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
G Protein-Coupled Receptor 1071 2     RP11-88G172
Lung Seven Transmembrane Receptor 12 3     bA138E2.22
LUSTR12 3     Protein GPR1072
GCDRP2     KIAA16243

External Ids:    HGNC: 178301   Entrez Gene: 577202   Ensembl: ENSG000001483587   UniProtKB: Q5VW383   

Export aliases for GPR107 gene to outside databases

Previous GC identifers: GC09P123930 GC09P124462 GC09P126269 GC09P128192 GC09P129895 GC09P131855 GC09P102415


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for GPR107 Gene: 
GPR107 (G protein-coupled receptor 107) is a protein-coding gene. Diseases associated with GPR107 include focal dermal hypoplasia, and nail-patella syndrome. An important paralog of this gene is GPR108.

Gene Wiki entry for GPR107 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GPR107 gene promoter:
         SRF   SRF (504 AA)   C/EBPalpha   Max   PPAR-gamma1   POU2F1   POU2F1a   PPAR-gamma2   c-Myc   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPR107 promoter sequence
   Search SABiosciences Chromatin IP Primers for GPR107

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPR107


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.11   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34.2

GPR107 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPR107 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P132815:  view genomic region     (about GC identifiers)

Start:
132,815,705 bp from pter      End:
132,902,448 bp from pter
Size:
86,744 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GP107_HUMAN, Q5VW38 (See protein sequence)
Recommended Name: Protein GPR107 precursor  
Size: 600 amino acids; 66990 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: A6NJ53 Q2TB81 Q5JPA3 Q5VW39 Q96T26 Q9H658 Q9HCE8
Alternative splicing: 3 isoforms:  Q5VW38-1   Q5VW38-2   Q5VW38-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GPR107: NX_Q5VW38

Explore proteomics data for GPR107 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5VW38

  • GPR107 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GPR107 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001130029.1  NP_001130030.1  NP_066011.2  

    ENSEMBL proteins: 
     ENSP00000361483   ENSP00000336988   ENSP00000475772   ENSP00000361487  

    Human Recombinant Protein Products for GPR107: 
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    Cloud-Clone Corp. Proteins for GPR107 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    GPR107 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    O7TM: GPCR / Unclassified : 7TM orphan receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: GPR107 
    Other 7TM proteins

    1 InterPro protein domain:
     IPR009637 TM_rcpt_euk

    Graphical View of Domain Structure for InterPro Entry Q5VW38

    ProtoNet protein and cluster: Q5VW38

    UniProtKB/Swiss-Prot: GP107_HUMAN, Q5VW38
    Similarity: Belongs to the LU7TM family


    GPR107 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         1 GenomeRNAi human phenotype for GPR107:
     Decreased TP53 protein express 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Gpr107):
     mortality/aging 

    GPR107 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GPR107 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GPR107 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GPR107

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for GPR107 (ENSP000003614834) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0019236response to pheromone ----

    GPR107 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GPR107 (GP107)

    Search CenterWatch for drugs/clinical trials and news about GPR107 / GP107

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GPR107 gene (3 alternative transcripts): 
    NM_001136557.1  NM_001136558.1  NM_020960.4  

    Unigene Cluster for GPR107:

    G protein-coupled receptor 107
    Hs.512461  [show with all ESTs]
    Unigene Representative Sequence: NM_001136557
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372406(uc004bze.2) ENST00000347136 ENST00000493417(uc004bzb.2)
    ENST00000462907 ENST00000483935 ENST00000415344 ENST00000372410(uc004bzg.1 uc011mbx.1 uc004bzd.2)

    miRNA
    Products:
         
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    8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate GPR107 (see all 30):
    hsa-miR-320a hsa-miR-498 hsa-miR-140-5p hsa-miR-125a-5p hsa-miR-429 hsa-miR-2110 hsa-miR-767-5p hsa-miR-1258
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
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    Additional mRNA sequence: 

    AB046844.1 AF308603.1 AF376725.1 AJ420422.1 AJ420428.1 AK000825.1 AK021506.1 AK024651.1 
    AK025836.1 AK074380.1 AK131317.1 AK225456.1 AK293092.1 AL834359.1 BC007544.1 BC030147.2 
    BC039728.1 BC040059.2 BC110518.2 BC143655.1 

    24 DOTS entries:

    DT.40120021  DT.100044675  DT.97864282  DT.95091643  DT.435785  DT.451679  DT.91652871  DT.95149652 
    DT.100696538  DT.102829156  DT.40248623  DT.403075  DT.91685267  DT.92048449  DT.95219567  DT.100780462 
    DT.121170120  DT.121170212  DT.40222107  DT.92407843  DT.95295915  DT.121170191  DT.91722404  DT.95084667 

    24/434 AceView cDNA sequences (see all 434):

    AA903757 AX776003 AA171874 BQ936788 BU543199 BQ019630 BF902182 BU634272 
    BU541718 AF308603 BQ937332 AI924896 AB046844 BU844524 AW316609 BU553856 
    BX101344 AI125153 AI364057 NM_020960 AW451329 AW472889 BE293611 BM850758 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for GPR107 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^
    SP1:                          -           -                                                                                                           -     -   
    SP2:                          -           -                                                                             -     -                       -     -   
    SP3:                          -           -                                                                             -     -                                 
    SP4:                          -           -                                   -     -     -                                                                     
    SP5:                                                                                                                                                            

    ExUns: 21a · 21b · 21c
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for GPR107

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GPR107 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGATGTACG
    GPR107 Expression
    About this image


    See GPR107 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GPR107

    SOURCE GeneReport for Unigene cluster: Hs.512461
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GPR107 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpr1071 , 5 G protein-coupled receptor 1071, 5 83.33(n)1
    87.17(a)1
      2 (21.80 cM)5
    2774631  NM_178760.41  NP_848875.21 
     311523165 
    chicken
    (Gallus gallus)
    Aves GPR1071 G protein-coupled receptor 107 73.63(n)
    77.99(a)
      417186  NM_001030686.1  NP_001025857.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CA474283.12   -- 74.14(n)    CA474283.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG121211 CG12121 55.25(n)
    51.18(a)
      31866  NM_132317.1  NP_572545.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C15H9.51 Protein C15H9.5 44.65(n)
    35(a)
      180881  NM_076619.2  NP_509020.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G420901 Lung seven transmembrane receptor family protein 51.88(n)
    44.05(a)
      834214  NM_123574.2  NP_199024.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g01321001 hypothetical protein 50(n)
    42.27(a)
      4340012  NM_001063233.1  NP_001056698.1 


    ENSEMBL Gene Tree for GPR107 (if available)
    TreeFam Gene Tree for GPR107 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GPR107 gene
    GPR1082  
    1 SIMAP similar gene for GPR107 using alignment to 3 protein entries:     GP107_HUMAN (see all proteins):
    GPR108

    GPR107 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2008 SNPs in GPR107 are shown (see all 2008)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1478141241,2
    --132814132(+) GACTAA/GGAGAG 3 -- us2k10--------
    rs48366861,2
    C,F,H--132814215(+) TGTAAC/TGTCCC 3 -- us2k119Minor allele frequency- T:0.03NS EA NA WA CSA 937
    rs1890487321,2
    --132814216(+) GTAATC/GTCCCT 3 -- us2k10--------
    rs1809588351,2
    --132814320(+) TTCTTC/GAAACT 3 -- us2k10--------
    rs1399853681,2
    --132814462(+) ATAATG/TACTGG 3 -- us2k10--------
    rs1454205381,2
    C--132814563(+) GATAAA/TACCCA 3 -- us2k10--------
    rs801765441,2
    F--132814625(+) CTGTTG/CTCCAG 3 -- us2k11Minor allele frequency- C:0.05WA 118
    rs1476716281,2
    C--132814858(+) AGGCGC/TGCGGC 3 -- us2k10--------
    rs1860881461,2
    --132814900(+) TAGAGA/GCGAGG 3 -- us2k10--------
    rs2005159651,2
    C--132814906(+) CGAGG-/TTTTGC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for GPR107 (132815705 - 132902448 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for GPR107:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2664800CNV Deletion23128226
    nsv6730CNV Insertion18451855
    nsv6732CNV Loss18451855
    nsv831733CNV Loss17160897
    nsv831732CNV Loss17160897
    nsv518603CNV Loss19592680
    nsv466590CNV Gain19166990
    nsv893931CNV Gain+Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    5 diseases for GPR107:    About MalaCards
    focal dermal hypoplasia    nail-patella syndrome    nevoid basal cell carcinoma syndrome    basal cell carcinoma
    spina bifida


    GPR107 for disorders           About GeneDecksing


    Export disorders for GPR107 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GPR107 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with GPR107)
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    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    3. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2 Nagase T.... Ohara O. (2000)
    4. Evidence for an interaction of neuronostatin with the orphan G protein-coupled receptor, GPR107. (PubMed id 22933024)1 Yosten G.L....Samson W.K. (2012)
    5. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. Human GPR107 and murine Gpr108 are members of the LUSTR family of proteins found in both plants and animals, having similar topology to G-protein coupled receptors. (PubMed id 17454009)1 Edgar A.J. (2007)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57720 HGNC: 17830 AceView: GPR107 Ensembl:ENSG00000148358 euGenes: HUgn57720
    ECgene: GPR107 H-InvDB: GPR107

    (According to HUGE)
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    HUGE: KIAA1624

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GPR107 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GPR107 gene:
    Search GeneIP for patents involving GPR107

    GeneCards and IP:
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