Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GPR107 Gene

Aliases for GPR107 Gene

  • G Protein-Coupled Receptor 107 2 3
  • Lung Seven Transmembrane Receptor 1 3 4
  • LUSTR1 3 4
  • Protein GPR107 3
  • BA138E2.2 3
  • KIAA1624 4
  • GCDRP 3

External Ids for GPR107 Gene

Summaries for GPR107 Gene

GeneCards Summary for GPR107 Gene

GPR107 (G Protein-Coupled Receptor 107) is a Protein Coding gene. An important paralog of this gene is GPR108.

UniProtKB/Swiss-Prot for GPR107 Gene

  • Involved in Golgi-to-ER retrograde transport. Functions as a host factor required for infection by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT toxins.

Gene Wiki entry for GPR107 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR107 Gene

Genomics for GPR107 Gene

Genomic Location for GPR107 Gene

Start:
130,053,426 bp from pter
End:
130,140,169 bp from pter
Size:
86,744 bases
Orientation:
Plus strand

Genomic View for GPR107 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPR107 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR107 Gene

Regulatory Elements for GPR107 Gene

Proteins for GPR107 Gene

  • Protein details for GPR107 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VW38-GP107_HUMAN
    Recommended name:
    Protein GPR107
    Protein Accession:
    Q5VW38
    Secondary Accessions:
    • A6NJ53
    • Q2TB81
    • Q5JPA3
    • Q5VW39
    • Q96T26
    • Q9H658
    • Q9HCE8

    Protein attributes for GPR107 Gene

    Size:
    600 amino acids
    Molecular mass:
    66990 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GPR107 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPR107 Gene

Proteomics data for GPR107 Gene at MOPED

Post-translational modifications for GPR107 Gene

  • Cleaved by a furin endopeptidase to yield two fragments of 17 and 35 kDa that remain associated via a disulfide bond.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn70, Ser157, Ser166, Asn169, Thr171, and Asn211

Other Protein References for GPR107 Gene

No data available for DME Specific Peptides for GPR107 Gene

Domains for GPR107 Gene

Gene Families for GPR107 Gene

HGNC:
  • O7TM :GPCR / Unclassified : 7TM orphan receptors
IUPHAR :

Protein Domains for GPR107 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

GP107_HUMAN
Family:
  • Belongs to the LU7TM family.:
    • Q5VW38
genes like me logo Genes that share domains with GPR107: view

Function for GPR107 Gene

Molecular function for GPR107 Gene

UniProtKB/Swiss-Prot Function: Involved in Golgi-to-ER retrograde transport. Functions as a host factor required for infection by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT toxins.

Phenotypes for GPR107 Gene

MGI mutant phenotypes for GPR107:
inferred from 1 alleles
GenomeRNAi human phenotypes for GPR107:
genes like me logo Genes that share phenotypes with GPR107: view

miRNA for GPR107 Gene

miRTarBase miRNAs that target GPR107

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for GPR107 Gene

Localization for GPR107 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR107 Gene

Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR107 Gene COMPARTMENTS Subcellular localization image for GPR107 gene
Compartment Confidence
plasma membrane 3
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GPR107 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR107: view

Pathways for GPR107 Gene

SuperPathways for GPR107 Gene

No Data Available

Interacting Proteins for GPR107 Gene

Gene Ontology (GO) - Biological Process for GPR107 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0019236 response to pheromone --
genes like me logo Genes that share ontologies with GPR107: view

No data available for Pathways by source for GPR107 Gene

Transcripts for GPR107 Gene

Unigene Clusters for GPR107 Gene

G protein-coupled receptor 107:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR107 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^
SP1: - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - - -
SP5:
SP6:
SP7: -

ExUns: 21a · 21b · 21c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for GPR107 Gene

GeneLoc Exon Structure for
GPR107
ECgene alternative splicing isoforms for
GPR107

Expression for GPR107 Gene

mRNA expression in normal human tissues for GPR107 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for GPR107 Gene

SOURCE GeneReport for Unigene cluster for GPR107 Gene Hs.512461

genes like me logo Genes that share expressions with GPR107: view

Orthologs for GPR107 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPR107 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR107 36
  • 99.82 (n)
  • 99.82 (a)
GPR107 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GPR107 36
  • 89.53 (n)
  • 91.83 (a)
GPR107 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPR107 36
  • 89.22 (n)
  • 92.31 (a)
GPR107 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr107 36
  • 83.4 (n)
  • 87.45 (a)
Gpr107 16
Gpr107 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPR107 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR107 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr107 36
  • 82.75 (n)
  • 85.5 (a)
chicken
(Gallus gallus)
Aves GPR107 36
  • 74.58 (n)
  • 79.38 (a)
GPR107 37
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr107 36
  • 66.73 (n)
  • 70.55 (a)
zebrafish
(Danio rerio)
Actinopterygii gpr107 36
  • 66.47 (n)
  • 66.67 (a)
gpr107 37
  • 60 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000913 36
  • 54.99 (n)
  • 51.01 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12121 36
  • 55.23 (n)
  • 50.98 (a)
CG12121 37
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C15H9.5 36
  • 45.58 (n)
  • 35.68 (a)
C15H9.5 37
  • 27 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.380 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G42090 36
  • 51.88 (n)
  • 44.05 (a)
rice
(Oryza sativa)
Liliopsida Os06g0132100 36
  • 49.68 (n)
  • 42.31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 54 (a)
OneToMany
Species with no ortholog for GPR107:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPR107 Gene

ENSEMBL:
Gene Tree for GPR107 (if available)
TreeFam:
Gene Tree for GPR107 (if available)

Paralogs for GPR107 Gene

Paralogs for GPR107 Gene

Selected SIMAP similar genes for GPR107 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GPR107: view

Variants for GPR107 Gene

Sequence variations from dbSNP and Humsavar for GPR107 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1306 -- 130,137,797(-) ACCGC(A/G)TGACA utr-variant-3-prime
rs8503 -- 130,139,940(-) CAAAC(A/G)AAACT utr-variant-3-prime
rs475169 -- 130,087,988(+) TCCAT(A/G)GATCA intron-variant
rs487416 -- 130,084,145(+) gtaat(C/T)ccagc intron-variant
rs495857 -- 130,085,089(+) CAGGC(A/T)ACGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR107 Gene

Variant ID Type Subtype PubMed ID
nsv893931 CNV Gain+Loss 21882294
nsv831732 CNV Loss 17160897
nsv831733 CNV Loss 17160897
nsv518603 CNV Loss 19592680
nsv466590 CNV Gain 19166990
nsv6730 CNV Insertion 18451855
nsv6732 CNV Loss 18451855
esv2664800 CNV Deletion 23128226

Relevant External Links for GPR107 Gene

HapMap Linkage Disequilibrium report
GPR107

Disorders for GPR107 Gene

No disorders were found for GPR107 Gene.

No data available for UniProtKB/Swiss-Prot for GPR107 Gene

Publications for GPR107 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  3. GPR107, a G-protein-coupled receptor essential for intoxication by Pseudomonas aeruginosa exotoxin A, localizes to the Golgi and is cleaved by furin. (PMID: 25031321) Tafesse F.G. … Ploegh H.L. (J. Biol. Chem. 2014) 3 4
  4. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for GPR107 Gene

Sources for GPR107 Gene

Back to Top

Content