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Aliases for GPR107 Gene

Aliases for GPR107 Gene

  • G Protein-Coupled Receptor 107 2 3 5
  • Lung Seven Transmembrane Receptor 1 3 4
  • LUSTR1 3 4
  • BA138E2.2 3
  • KIAA1624 4
  • GCDRP 3

External Ids for GPR107 Gene

Previous GeneCards Identifiers for GPR107 Gene

  • GC09P123930
  • GC09P124462
  • GC09P126269
  • GC09P128192
  • GC09P129895
  • GC09P131855
  • GC09P132815
  • GC09P102415

Summaries for GPR107 Gene

GeneCards Summary for GPR107 Gene

GPR107 (G Protein-Coupled Receptor 107) is a Protein Coding gene. An important paralog of this gene is GPR108.

UniProtKB/Swiss-Prot for GPR107 Gene

  • Involved in Golgi-to-ER retrograde transport. Functions as a host factor required for infection by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT toxins.

Gene Wiki entry for GPR107 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR107 Gene

Genomics for GPR107 Gene

Regulatory Elements for GPR107 Gene

Enhancers for GPR107 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPR107 on UCSC Golden Path with GeneCards custom track

Promoters for GPR107 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPR107 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR107 Gene

130,053,426 bp from pter
130,140,169 bp from pter
86,744 bases
Plus strand

Genomic View for GPR107 Gene

Genes around GPR107 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR107 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR107 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR107 Gene

Proteins for GPR107 Gene

  • Protein details for GPR107 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein GPR107
    Protein Accession:
    Secondary Accessions:
    • A6NJ53
    • Q2TB81
    • Q5JPA3
    • Q5VW39
    • Q96T26
    • Q9H658
    • Q9HCE8

    Protein attributes for GPR107 Gene

    600 amino acids
    Molecular mass:
    66990 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GPR107 Gene


neXtProt entry for GPR107 Gene

Proteomics data for GPR107 Gene at MOPED

Post-translational modifications for GPR107 Gene

  • Cleaved by a furin endopeptidase to yield two fragments of 17 and 35 kDa that remain associated via a disulfide bond.
  • Glycosylation at Asn 70, Asn 169, and Asn 211
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR107 Gene

No data available for DME Specific Peptides for GPR107 Gene

Domains & Families for GPR107 Gene

Gene Families for GPR107 Gene

Protein Domains for GPR107 Gene


Suggested Antigen Peptide Sequences for GPR107 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the LU7TM family.
  • Belongs to the LU7TM family.
genes like me logo Genes that share domains with GPR107: view

Function for GPR107 Gene

Molecular function for GPR107 Gene

UniProtKB/Swiss-Prot Function:
Involved in Golgi-to-ER retrograde transport. Functions as a host factor required for infection by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT toxins.
genes like me logo Genes that share phenotypes with GPR107: view

Animal Models for GPR107 Gene

MGI Knock Outs for GPR107:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR107

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR107 Gene

Localization for GPR107 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR107 Gene

Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GPR107 Gene COMPARTMENTS Subcellular localization image for GPR107 gene
Compartment Confidence
golgi apparatus 4
plasma membrane 3
endosome 2
nucleus 2

Gene Ontology (GO) - Cellular Components for GPR107 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IEA --
genes like me logo Genes that share ontologies with GPR107: view

Pathways & Interactions for GPR107 Gene

SuperPathways for GPR107 Gene

No Data Available

Interacting Proteins for GPR107 Gene

Gene Ontology (GO) - Biological Process for GPR107 Gene


No data available for Pathways by source and SIGNOR curated interactions for GPR107 Gene

Drugs & Compounds for GPR107 Gene

No Compound Related Data Available

Transcripts for GPR107 Gene

Unigene Clusters for GPR107 Gene

G protein-coupled receptor 107:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR107 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^
SP1: - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - - -
SP7: -

ExUns: 21a · 21b · 21c

Relevant External Links for GPR107 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR107 Gene

mRNA expression in normal human tissues for GPR107 Gene

Protein differential expression in normal tissues from HIPED for GPR107 Gene

This gene is overexpressed in Nasal epithelium (55.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for GPR107 Gene

SOURCE GeneReport for Unigene cluster for GPR107 Gene Hs.512461

genes like me logo Genes that share expression patterns with GPR107: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GPR107 Gene

Orthologs for GPR107 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPR107 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPR107 35
  • 89.53 (n)
  • 91.83 (a)
GPR107 36
  • 91 (a)
(Canis familiaris)
Mammalia GPR107 35
  • 89.22 (n)
  • 92.31 (a)
GPR107 36
  • 91 (a)
(Mus musculus)
Mammalia Gpr107 35
  • 83.4 (n)
  • 87.45 (a)
Gpr107 16
Gpr107 36
  • 85 (a)
(Pan troglodytes)
Mammalia GPR107 35
  • 99.82 (n)
  • 99.82 (a)
GPR107 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Gpr107 35
  • 82.75 (n)
  • 85.5 (a)
(Monodelphis domestica)
Mammalia GPR107 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia GPR107 36
  • 77 (a)
(Gallus gallus)
Aves GPR107 35
  • 74.58 (n)
  • 79.38 (a)
GPR107 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr107 35
  • 66.73 (n)
  • 70.55 (a)
(Danio rerio)
Actinopterygii gpr107 35
  • 66.47 (n)
  • 66.67 (a)
gpr107 36
  • 60 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000913 35
  • 54.99 (n)
  • 51.01 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12121 35
  • 55.23 (n)
  • 50.98 (a)
CG12121 36
  • 34 (a)
(Caenorhabditis elegans)
Secernentea C15H9.5 35
  • 45.58 (n)
  • 35.68 (a)
C15H9.5 36
  • 27 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G42090 35
  • 51.88 (n)
  • 44.05 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.380 35
(Oryza sativa)
Liliopsida Os06g0132100 35
  • 49.68 (n)
  • 42.31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
Species with no ortholog for GPR107:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPR107 Gene

Gene Tree for GPR107 (if available)
Gene Tree for GPR107 (if available)

Paralogs for GPR107 Gene

Paralogs for GPR107 Gene

(1) SIMAP similar genes for GPR107 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GPR107: view

Variants for GPR107 Gene

Sequence variations from dbSNP and Humsavar for GPR107 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs640343 - 130,086,420(+) TTTAG(C/G)CCATG reference, missense, utr-variant-5-prime
rs669390 -- 130,086,963(+) GCATA(C/T)GTATG intron-variant
rs674305 -- 130,081,505(+) cgtct(A/C)tacta intron-variant
rs684948 -- 130,062,664(+) tgcct(G/T)ccttc intron-variant
rs758845 -- 130,120,353(+) CGTGG(C/T)GACGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR107 Gene

Variant ID Type Subtype PubMed ID
nsv893931 CNV Gain+Loss 21882294
nsv831732 CNV Loss 17160897
nsv831733 CNV Loss 17160897
nsv518603 CNV Loss 19592680
nsv466590 CNV Gain 19166990
nsv6730 CNV Insertion 18451855
nsv6732 CNV Loss 18451855
esv2664800 CNV Deletion 23128226

Variation tolerance for GPR107 Gene

Residual Variation Intolerance Score: 22.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.71; 46.42% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GPR107 Gene

Disorders for GPR107 Gene

Relevant External Links for GPR107

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GPR107 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR107 Gene

Publications for GPR107 Gene

  1. GPR107, a G-protein-coupled receptor essential for intoxication by Pseudomonas aeruginosa exotoxin A, localizes to the Golgi and is cleaved by furin. (PMID: 25031321) Tafesse F.G. … Ploegh H.L. (J. Biol. Chem. 2014) 3 4 67
  2. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  3. Evidence for an interaction of neuronostatin with the orphan G protein-coupled receptor, GPR107. (PMID: 22933024) Yosten G.L. … Samson W.K. (Am. J. Physiol. Regul. Integr. Comp. Physiol. 2012) 3
  4. Human GPR107 and murine Gpr108 are members of the LUSTR family of proteins found in both plants and animals, having similar topology to G-protein coupled receptors. (PMID: 17454009) Edgar A.J. (DNA Seq. 2007) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for GPR107 Gene

Sources for GPR107 Gene