Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GPR101 Gene

Aliases for GPR101 Gene

  • G Protein-Coupled Receptor 101 2 3 5
  • GPCR6 3
  • PAGH2 3

External Ids for GPR101 Gene

Previous GeneCards Identifiers for GPR101 Gene

  • GC0XM130684
  • GC0XM132957
  • GC0XM134057
  • GC0XM134817
  • GC0XM135837
  • GC0XM135939
  • GC0XM136112
  • GC0XM125379

Summaries for GPR101 Gene

Entrez Gene Summary for GPR101 Gene

  • The protein encoded by this gene is an orphan G protein-coupled receptor of unknown function. The encoded protein is a member of a family of proteins that contain seven transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. [provided by RefSeq, Sep 2011]

GeneCards Summary for GPR101 Gene

GPR101 (G Protein-Coupled Receptor 101) is a Protein Coding gene. Diseases associated with GPR101 include pituitary adenoma, growth hormone-secreting 2 and chromosome xq26.3 duplication syndrome. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR176.

UniProtKB/Swiss-Prot for GPR101 Gene

  • Orphan receptor.

Gene Wiki entry for GPR101 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR101 Gene

Genomics for GPR101 Gene

Regulatory Elements for GPR101 Gene

Promoters for GPR101 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPR101 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR101 Gene

Chromosome:
X
Start:
137,030,148 bp from pter
End:
137,031,674 bp from pter
Size:
1,527 bases
Orientation:
Minus strand

Genomic View for GPR101 Gene

Genes around GPR101 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR101 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR101 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR101 Gene

Proteins for GPR101 Gene

  • Protein details for GPR101 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96P66-GP101_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 101
    Protein Accession:
    Q96P66
    Secondary Accessions:
    • Q5JSM8
    • Q8NG93

    Protein attributes for GPR101 Gene

    Size:
    508 amino acids
    Molecular mass:
    56716 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC06152.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for GPR101 Gene

Proteomics data for GPR101 Gene at MOPED

Post-translational modifications for GPR101 Gene

  • Glycosylation at Asn 7 and Asn 13
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR101 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for GPR101

No data available for DME Specific Peptides for GPR101 Gene

Domains & Families for GPR101 Gene

Gene Families for GPR101 Gene

Protein Domains for GPR101 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR101 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96P66

UniProtKB/Swiss-Prot:

GP101_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR101: view

Function for GPR101 Gene

Molecular function for GPR101 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.
genes like me logo Genes that share phenotypes with GPR101: view

Human Phenotype Ontology for GPR101 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GPR101 Gene

Localization for GPR101 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR101 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR101 Gene COMPARTMENTS Subcellular localization image for GPR101 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
genes like me logo Genes that share ontologies with GPR101: view

Pathways & Interactions for GPR101 Gene

SuperPathways for GPR101 Gene

No Data Available

Interacting Proteins for GPR101 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000298110%0d%0a9606.ENSP00000254108%0d%0a9606.ENSP00000349238%0d%0a9606.ENSP00000400717%0d%0a
Selected Interacting proteins: ENSP00000298110 for GPR101 Gene via STRING

Gene Ontology (GO) - Biological Process for GPR101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007267 cell-cell signaling IBA --
genes like me logo Genes that share ontologies with GPR101: view

No data available for Pathways by source and SIGNOR curated interactions for GPR101 Gene

Drugs & Compounds for GPR101 Gene

No Compound Related Data Available

Transcripts for GPR101 Gene

mRNA/cDNA for GPR101 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR101 Gene

G protein-coupled receptor 101:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR101 Gene

No ASD Table

Relevant External Links for GPR101 Gene

GeneLoc Exon Structure for
GPR101
ECgene alternative splicing isoforms for
GPR101

Expression for GPR101 Gene

mRNA expression in normal human tissues for GPR101 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR101 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x30.5), Brain - Hypothalamus (x7.0), Brain - Caudate (basal ganglia) (x6.9), and Brain - Putamen (basal ganglia) (x5.6).

Protein differential expression in normal tissues from HIPED for GPR101 Gene

This gene is overexpressed in Plasma (64.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR101 Gene



SOURCE GeneReport for Unigene cluster for GPR101 Gene Hs.350569

genes like me logo Genes that share expression patterns with GPR101: view

Protein tissue co-expression partners for GPR101 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GPR101 Gene

Orthologs for GPR101 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR101 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPR101 35
  • 87.84 (n)
  • 87.37 (a)
GPR101 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPR101 35
  • 87.33 (n)
  • 85.6 (a)
GPR101 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr101 35
  • 79.53 (n)
  • 72.6 (a)
Gpr101 16
Gpr101 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPR101 35
  • 99.67 (n)
  • 99.61 (a)
GPR101 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr101 35
  • 78.93 (n)
  • 72.8 (a)
oppossum
(Monodelphis domestica)
Mammalia GPR101 36
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR101 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr101 35
  • 58.23 (n)
  • 53.66 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101886313 35
  • 55.03 (n)
  • 47.51 (a)
GPR101 36
  • 35 (a)
OneToOne
Species with no ortholog for GPR101:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR101 Gene

ENSEMBL:
Gene Tree for GPR101 (if available)
TreeFam:
Gene Tree for GPR101 (if available)

Paralogs for GPR101 Gene

Paralogs for GPR101 Gene

genes like me logo Genes that share paralogs with GPR101: view

Variants for GPR101 Gene

Sequence variations from dbSNP and Humsavar for GPR101 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1190736 - 137,031,305(+) CACCA(A/C)GACAA reference, missense
rs5931046 - 137,030,548(+) GTGGG(A/G)GGCTC reference, missense
rs73637412 Pituitary adenoma, growth hormone-secreting, 2 (PAGH2) 137,030,751(+) CTGCT(C/G/T)TCTCT reference, synonymous-codon, missense
rs41310741 -- 137,030,507(+) CCTGG(G/T)CAGAG reference, missense
rs73566014 -- 137,030,797(+) CACTG(A/G)TCCCC reference, missense

Variation tolerance for GPR101 Gene

Residual Variation Intolerance Score: 93.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.38; 92.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR101 Gene

HapMap Linkage Disequilibrium report
GPR101
Human Gene Mutation Database (HGMD)
GPR101

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GPR101 Gene

Disorders for GPR101 Gene

MalaCards: The human disease database

(6) MalaCards diseases for GPR101 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
pituitary adenoma, growth hormone-secreting 2
  • pituitary adenoma, growth hormone-secreting, 2
chromosome xq26.3 duplication syndrome
  • x-linked acrogigantism
acromegaly
  • somatotroph adenoma
pituitary adenoma, growth hormone-secreting
  • acromegaly, somatic
gigantism
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

GP101_HUMAN
  • Pituitary adenoma, growth hormone-secreting, 2 (PAGH2) [MIM:300943]: A growth hormone-secreting, benign neoplasm of the anterior pituitary gland, also known as somatotropinoma. It clinically results in acromegaly, a condition characterized by coarse facial features, protruding jaw, and enlarged extremities. Excessive production of growth hormone in children or adolescents before the closure of epiphyses causes gigantism, a condition characterized by abnormally tall stature. {ECO:0000269 PubMed:25470569}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for GPR101

Genetic Association Database (GAD)
GPR101
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR101
genes like me logo Genes that share disorders with GPR101: view

No data available for Genatlas for GPR101 Gene

Publications for GPR101 Gene

  1. Discovery and mapping of ten novel G protein-coupled receptor genes. (PMID: 11574155) Lee D.K. … O'Dowd B.F. (Gene 2001) 2 3 4 67
  2. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3
  3. Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy. (PMID: 26460568) Johnson-Kerner B.L. … Wichterle H. (PLoS ONE 2015) 3
  4. GnRH-(1-5) transactivates EGFR in Ishikawa human endometrial cells via an orphan G protein-coupled receptor. (PMID: 24264576) Cho-Clark M. … Wu T.J. (Mol. Endocrinol. 2014) 3
  5. Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation. (PMID: 25470569) Trivellin G. … Stratakis C.A. (N. Engl. J. Med. 2014) 3

Products for GPR101 Gene

Sources for GPR101 Gene

Back to Top

Content