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Aliases for GPR1 Gene

Aliases for GPR1 Gene

  • G Protein-Coupled Receptor 1 2 3

External Ids for GPR1 Gene

Previous GeneCards Identifiers for GPR1 Gene

  • GC02M205257
  • GC02M205764
  • GC02M207003
  • GC02M207242
  • GC02M206865
  • GC02M206748
  • GC02M198888

Summaries for GPR1 Gene

GeneCards Summary for GPR1 Gene

GPR1 (G Protein-Coupled Receptor 1) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is FPR2.

UniProtKB/Swiss-Prot for GPR1 Gene

  • Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation. Can act as a coreceptor for HIV-1.

Gene Wiki entry for GPR1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR1 Gene

Genomics for GPR1 Gene

Regulatory Elements for GPR1 Gene

Genomic Location for GPR1 Gene

Start:
206,175,316 bp from pter
End:
206,218,047 bp from pter
Size:
42,732 bases
Orientation:
Minus strand

Genomic View for GPR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR1 Gene

Proteins for GPR1 Gene

  • Protein details for GPR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46091-GPR1_HUMAN
    Recommended name:
    G-protein coupled receptor 1
    Protein Accession:
    P46091
    Secondary Accessions:
    • A5JUU6
    • A8K4L1
    • Q53TR9
    • Q6NVX4

    Protein attributes for GPR1 Gene

    Size:
    355 amino acids
    Molecular mass:
    41431 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR1 Gene

Proteomics data for GPR1 Gene at MOPED

Post-translational modifications for GPR1 Gene

  • Glycosylation at Asn14
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPR1 Gene

Domains for GPR1 Gene

Gene Families for GPR1 Gene

HGNC:
  • GPCRAO :GPCR / Class A : Orphans
IUPHAR :

Protein Domains for GPR1 Gene

Suggested Antigen Peptide Sequences for GPR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P46091

UniProtKB/Swiss-Prot:

GPR1_HUMAN :
  • P46091
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR1: view

Function for GPR1 Gene

Molecular function for GPR1 Gene

GENATLAS Biochemistry: G protein coupled receptor 1,expressed in hippocampus,functioning in a RAS-independent pathway with a large third cytoplasmic loop and a large cytoplasmic tail
UniProtKB/Swiss-Prot Function: Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation. Can act as a coreceptor for HIV-1.

Gene Ontology (GO) - Molecular Function for GPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0042923 neuropeptide binding IBA --
genes like me logo Genes that share ontologies with GPR1: view

Animal Model Products

CRISPR Products

miRNA for GPR1 Gene

miRTarBase miRNAs that target GPR1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for GPR1 Gene

Localization for GPR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR1 Gene COMPARTMENTS Subcellular localization image for GPR1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for GPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 7851889
GO:0016021 integral component of membrane --
GO:0043005 neuron projection IBA --
genes like me logo Genes that share ontologies with GPR1: view

Pathways for GPR1 Gene

SuperPathways for GPR1 Gene

genes like me logo Genes that share pathways with GPR1: view

Pathways by source for GPR1 Gene

1 BioSystems pathway for GPR1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for GPR1 Gene

Gene Ontology (GO) - Biological Process for GPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway TAS 7851889
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA --
GO:0007218 neuropeptide signaling pathway IBA --
GO:0007268 synaptic transmission IBA --
genes like me logo Genes that share ontologies with GPR1: view

Compounds for GPR1 Gene

(2) IUPHAR Ligand for GPR1 Gene

Ligand Type Action Affinity Pubmed IDs
chemerin Agonist Full agonist 8.31
chemerin C-terminal peptide Agonist Agonist
genes like me logo Genes that share compounds with GPR1: view

Transcripts for GPR1 Gene

Unigene Clusters for GPR1 Gene

G protein-coupled receptor 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPR1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: - -
SP2: - -
SP3: - - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for GPR1 Gene

GeneLoc Exon Structure for
GPR1
ECgene alternative splicing isoforms for
GPR1

Expression for GPR1 Gene

mRNA expression in normal human tissues for GPR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR1 Gene

This gene is overexpressed in Vagina (4.5) and Skin - Sun Exposed (Lower leg) (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GPR1 Gene

SOURCE GeneReport for Unigene cluster for GPR1 Gene Hs.184907

mRNA Expression by UniProt/SwissProt for GPR1 Gene

P46091-GPR1_HUMAN
Tissue specificity: Expressed in hippocampus
genes like me logo Genes that share expressions with GPR1: view

In Situ Assay Products

Orthologs for GPR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR1 35
  • 99.62 (n)
  • 99.72 (a)
GPR1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GPR1 35
  • 87.61 (n)
  • 87.89 (a)
GPR1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPR1 35
  • 89.86 (n)
  • 89.86 (a)
GPR1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr1 35
  • 83.14 (n)
  • 81.47 (a)
Gpr1 16
Gpr1 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPR1 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR1 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr1 35
  • 81.76 (n)
  • 80 (a)
chicken
(Gallus gallus)
Aves GPR1 35
  • 68.83 (n)
  • 66.96 (a)
GPR1 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR1 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr1 35
  • 59.88 (n)
  • 54.57 (a)
zebrafish
(Danio rerio)
Actinopterygii gpr1 35
  • 52.48 (n)
  • 40.06 (a)
gpr1 36
  • 37 (a)
OneToOne
Species with no ortholog for GPR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR1 Gene

ENSEMBL:
Gene Tree for GPR1 (if available)
TreeFam:
Gene Tree for GPR1 (if available)

Paralogs for GPR1 Gene

genes like me logo Genes that share paralogs with GPR1: view

Variants for GPR1 Gene

Sequence variations from dbSNP and Humsavar for GPR1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1060384 -- 206,177,055(-) CGGGG(C/T)TCAAG missense, reference
rs1362466 -- 206,190,632(+) TTGGC(A/G)TTGAA intron-variant
rs1544648 -- 206,193,522(+) ACTGG(A/G)CAACT intron-variant
rs1894913 -- 206,185,368(+) aatta(C/G)tcgtg intron-variant
rs2010572 -- 206,199,101(+) TTTCC(C/T)TGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR1 Gene

Variant ID Type Subtype PubMed ID
nsv875737 CNV Gain 21882294

Relevant External Links for GPR1 Gene

HapMap Linkage Disequilibrium report
GPR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR1 Gene

Disorders for GPR1 Gene

(1) Novoseek inferred disease relationships for GPR1 Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 52.6 2

Relevant External Links for GPR1

Genetic Association Database (GAD)
GPR1
Human Genome Epidemiology (HuGE) Navigator
GPR1
genes like me logo Genes that share disorders with GPR1: view

No data available for UniProtKB/Swiss-Prot for GPR1 Gene

Publications for GPR1 Gene

  1. Cloning of human genes encoding novel G protein-coupled receptors. (PMID: 7851889) Marchese A. … O'Dowd B.F. (Genomics 1994) 2 3 4 23
  2. An orphan G protein-coupled receptor, GPR1, acts as a coreceptor to allow replication of human immunodeficiency virus types 1 and 2 in brain-derived cells. (PMID: 10233994) Shimizu N. … Hoshino H. (J. Virol. 1999) 3 4 23
  3. Infection of mesangial cells with HIV and SIV: identification of GPR1 as a coreceptor. (PMID: 10916084) Tokizawa S. … Hoshino H. (Kidney Int. 2000) 3 23
  4. The synthetic peptide derived from the NH2-terminal extracellular region of an orphan G protein-coupled receptor, GPR1, preferentially inhibits infection of X4 HIV-1. (PMID: 15919664) Jinno-Oue A. … Hoshino H. (J. Biol. Chem. 2005) 3 23
  5. Short communication: identification of the conformational requirement for the specificities of coreceptors for human and simian immunodeficiency viruses. (PMID: 20334567) Shimizu N. … Hoshino H. (AIDS Res. Hum. Retroviruses 2010) 3 23

Products for GPR1 Gene

Sources for GPR1 Gene

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