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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GPR1 Gene

protein-coding   GIFtS: 56
GCID: GC02M207003

G protein-coupled receptor 1

 Explore 3 diseases affiliated with
GPR1 via our new
 Human Malady Compendium 
Biological research products
for GPR1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
G Protein-Coupled Receptor 11 2
G-Protein Coupled Receptor 12
Probable G-Protein Coupled Receptor 12

External Ids:    HGNC: 44631   Entrez Gene: 28252   Ensembl: ENSG000001836717   OMIM: 6002395   UniProtKB: P460913   

Export aliases for GPR1 gene to outside databases

Previous GC identifers: GC02M205257 GC02M205764 GC02M207242 GC02M206865 GC02M206748 GC02M198888


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: GPR1_HUMAN, P46091
Function: Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for
this receptor in the regulation of inflammation. Can act as a coreceptor for HIV-1

Gene Wiki entry for GPR1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GPR1 gene promoter:
         TBP   AML1a   Bach2   POU3F2   Evi-1   Max   Nkx6-1   TFIID   SEF-1 (1)   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for GPR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.3   Ensembl cytogenetic band:  2q33.3   HGNC cytogenetic band: 2q33.3

GPR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPR1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M207003:  view genomic region     (about GC identifiers)

Start:
207,040,040 bp from pter      End:
207,082,771 bp from pter
Size:
42,732 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GPR1_HUMAN, P46091 (See protein sequence)
Recommended Name: G-protein coupled receptor 1  
Size: 355 amino acids; 41431 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: A5JUU6 A8K4L1 Q53TR9 Q6NVX4

Explore the universe of human proteins at neXtProt for GPR1: NX_P46091

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P46091

  • GPR1 Protein expression data from MOPED and PaxDb: --
    REFSEQ proteins (6 alternative transcripts): 
    NP_001091669.1  NP_001248381.1  NP_001248382.1  NP_001248383.1  NP_001248384.1  NP_005270.2  

    ENSEMBL proteins: 
     ENSP00000384345   ENSP00000397535   ENSP00000414836   ENSP00000391146   ENSP00000414524  
     ENSP00000409577   ENSP00000404861   ENSP00000416474  

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    Uscn Proteins for GPR1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane TAS7851889
    GO:0016021integral to membrane ----


    GPR1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    GPR1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR002275 GPR1_rcpt
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P46091

    ProtoNet protein and cluster: P46091

    1 Blocks protein family: IPB002275 GPR1 orphan receptor signature

    UniProtKB/Swiss-Prot: GPR1_HUMAN, P46091
    Similarity: Belongs to the G-protein coupled receptor 1 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: GPR1_HUMAN, P46091
    Function: Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for
    this receptor in the regulation of inflammation. Can act as a coreceptor for HIV-1

         Genatlas biochemistry entry for GPR1:
    G protein coupled receptor 1,expressed in hippocampus,functioning in a RAS-independent pathway with a large third
    cytoplasmic loop and a large cytoplasmic tail

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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--


    GPR1 for ontologies           About GeneDecksing


    Animal Models:
         1 MGI phenotypic allele for Gpr1 (no phenotypes)

    GPR1 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Class A/1 (Rhodopsin-like receptors)
    GPCRs, Class A Rhodopsin-like0.41


    1 BioSystems Pathway for GPR1 
        GPCRs, Class A Rhodopsin-like


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GPR1

    3 Interacting proteins for GPR1 (P460913) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNAI1P630963I2D: score=1 
    TPST1O605073I2D: score=1 
    TPST2O607043I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS7851889


    GPR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GPR1
    Search CenterWatch for drugs/clinical trials and news about GPR1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GPR1 gene (6 alternative transcripts): 
    NM_001098199.1  NM_001261452.1  NM_001261453.1  NM_001261454.1  NM_001261455.1  NM_005279.3  

    Unigene Cluster for GPR1:

    G protein-coupled receptor 1
    Hs.184907  [show with all ESTs]
    Unigene Representative Sequence: NM_001261453
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000407325(uc002vbl.4 uc010fue.3 uc010fuf.3) ENST00000437420
    ENST00000442134 ENST00000451790 ENST00000447845 ENST00000439932 ENST00000411719
    ENST00000458440

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    1 QIAGEN miScript miRNA Assays for microRNA that regulate GPR1:
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    Inhib. RNA
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    Additional cDNA sequence: 

    AK075130.1 AK290976.1 AK312917.1 BC067833.1 EF577403.1 

    4 DOTS entries:

    DT.101968502  DT.121032549  DT.121032546  DT.121032550 

    24/34 AceView cDNA sequences (see all 34):

    BX389744 CR601592 NM_005279 CR612018 CA446989 BM888055 AI753131 AU153607 
    BV183432 CB992712 BX389743 BC067833 BP374650 AL574547 CN480238 AK075130 
    AL543530 AA181705 BC058005 CB269800 BX094581 AU280394 AL550780 BX336403 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for GPR1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e
    SP1:                          -                 -                                 
    SP2:                          -                 -                                 
    SP3:                    -     -                 -                                 
    SP4:                    -     -                 -                                 
    SP5:                                            -                                 


    ECgene alternative splicing isoforms for GPR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GPR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTACTTAAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    GPR1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    PureStem™ progenitor T42 (Embryonic Progenitor Cell)
    PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor E69 (Embryonic Progenitor Cell)
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    Genevestigator expression for GPR1

    SOURCE GeneReport for Unigene cluster: Hs.184907

    UniProtKB/Swiss-Prot: GPR1_HUMAN, P46091
    Tissue specificity: Expressed in hippocampus

        SABiosciences Expression via Pathway-Focused PCR Array including GPR1: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for GPR1 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves GPR11 G protein-coupled receptor 1 68.99(n)
    67.15(a)
      424101  XM_421955.3  XP_421955.1 
    lizard
    (Anolis carolinensis)
    Reptilia GPR16
    --
    (see all 3)
    --
    59(a)
    29(a)
    (see all 3)
    1 ↔ 1
    possible ortholog
    (see all 3)
    GL343208.1(626368-627465)
    GL343281.1(1650766-1655288)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000041241 probable G-protein coupled receptor 1-like 52.24(n)
    39.63(a)
      100004124  XM_001343478.3  XP_001343514.1 


    ENSEMBL Gene Tree for GPR1 (if available)
    TreeFam Gene Tree for GPR1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GPR1 gene
    LTB4R2  LTB4R22  FPR32  FPR12  C5AR12  GPR322  GPR1522  FPR22  
    C5AR22  C3AR12  PTGDR22  CMKLR12  
    18/37 SIMAP similar genes for GPR1 using alignment to 7 protein entries:     GPR1_HUMAN (see all proteins) (see all similar genes):
    C3AR1    GPR18    BDKRB1    CCR3    GPR33    CMKLR1
    AGTR1    CX3CR1    LTB4R    gpcr    LTB4R2    CCR5
    C5AR1    CCR-5    CCR1    FPR1    FPR2    FPR3

    GPR1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/749 NCBI SNPs in GPR1 are shown (see all 749    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs729448641,2
    C,F,--207039556(+) GAAATT/GTCCAC 6 -- int11Minor allele frequency- G:0.09WA 118
    rs129971361,2
    C,F,H,--207039604(+) TCTGGC/TGACCC 6 -- int120Minor allele frequency- T:0.33NS EA NA WA CSA 1806
    rs730678781,2
    C,--207039631(+) AATAGC/TTGTGT 6 -- int12Minor allele frequency- T:0.04WA 120
    rs1163678371,2
    C,--207039727(+) AGATAC/TTGCAA 6 -- int10--------
    rs1860905301,2
    --207039778(+) CCTGAA/CCCTCA 6 -- int10--------
    rs1451635181,2
    --207039800(+) ATTATA/GTCAAA 6 -- int10--------
    rs730678801,2
    C,--207039869(+) CTGGGT/CTTTTG 6 -- int12Minor allele frequency- C:0.04WA 120
    rs1911574371,2
    --207040081(+) GTATAC/TACATA 6 -- ut310--------
    rs1487236021,2
    --207040333(+) TCTCCC/TGCTTC 6 -- ut310--------
    rs1838141251,2
    --207040363(+) TTTGCA/GGACAT 6 -- ut310--------

    HapMap Linkage Disequilibrium report for GPR1 (207040040 - 207082771 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for GPR1: --
    Human Gene Mutation Database (HGMD): GPR1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GPR1
    DNA2.0 Custom Variant and Variant Library Synthesis for GPR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    GPR1 for disorders           About GeneDecksing

    OMIM gene information: 600239    OMIM disorders: --

    3 diseases for GPR1:    About MalaCards
    asthma    dementia    immunodeficiency

    1 Novoseek disease relationship for GPR1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 52.6 3 9791028 (1), 10233994 (1)

    Human Genome Epidemiology (HuGE) Navigator: GPR1 (2 documents)

    Export disorders for GPR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GPR1 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with GPR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of human genes encoding novel G protein-coupled receptors. (PubMed id 7851889)1, 2, 3, 9 Marchese A.... O'Dowd B.F. (1994)
    2. An orphan G protein-coupled receptor, GPR1, acts as a coreceptor to allow replication of human immunodeficiency virus types 1 and 2 in brain-derived cells. (PubMed id 10233994)1, 2, 9 Shimizu N....Hoshino H. (1999)
    3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Short communication: identification of the conformati onal requirement for the specificities of coreceptors for human and simian immu nodeficiency viruses. (PubMed id 20334567)1, 9 Shimizu N....Hoshino H. (2010)
    7. Infection of mesangial cells with HIV and SIV: identification of GPR1 as a coreceptor. (PubMed id 10916084)1, 9 Tokizawa S....Hoshino H. (2000)
    8. The synthetic peptide derived from the NH2-terminal extracellular region of an orphan G protein-coupled receptor, GPR1, preferentially inhibits infection of X4 HIV-1. (PubMed id 15919664)1, 9 Jinno-Oue A....Hoshino H. (2005)
    9. Use of (alternative) coreceptors for HIV entry. (PubMed id 22842622)1 Pollakis G. and Paxton W.A. (2012)
    10. Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared wit h bipolar disorder. (PubMed id 22688191)1 Bergen S.E....Sullivan P.F. (2012)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2825 HGNC: 4463 AceView: GPR1 Ensembl:ENSG00000183671 euGenes: HUgn2825
    ECgene: GPR1 H-InvDB: GPR1

    (According to HUGE)
    About This Section
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for GPR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for GPR1 gene:
    Search GeneIP for patents involving GPR1

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