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Aliases for GPR1 Gene

Aliases for GPR1 Gene

  • G Protein-Coupled Receptor 1 2 3 5

External Ids for GPR1 Gene

Previous GeneCards Identifiers for GPR1 Gene

  • GC02M205257
  • GC02M205764
  • GC02M207003
  • GC02M207242
  • GC02M206865
  • GC02M206748
  • GC02M198888

Summaries for GPR1 Gene

GeneCards Summary for GPR1 Gene

GPR1 (G Protein-Coupled Receptor 1) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and neuropeptide binding. An important paralog of this gene is CMKLR1.

UniProtKB/Swiss-Prot for GPR1 Gene

  • Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation. Can act as a coreceptor for HIV-1.

Gene Wiki entry for GPR1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR1 Gene

Genomics for GPR1 Gene

Regulatory Elements for GPR1 Gene

Enhancers for GPR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G206246 0.6 Ensembl 28.2 -28.3 -28254 0.2 MTA2 BHLHE40 NBN RELB DPF2 TBX21 GPR1 RN7SKP200 ZDBF2 SNORA41 EEF1B2 ADAM23 LOC100132849 HMGN1P6
GH02G206211 1.1 Ensembl ENCODE 12.9 +5.3 5333 2.7 PKNOX1 ZNF133 FEZF1 ZNF2 RFX5 SCRT2 FOS ZNF362 CEBPB ZNF488 GPR1 GPR1-AS
GH02G206250 0.8 Ensembl ENCODE 11.4 -32.5 -32452 0.6 CTCF RNF2 SUZ12 POLR2A RAD21 EZH2 ZDBF2 RN7SKP200 GPR1 SNORA41 EEF1B2 SNORD51 NDUFS1 HMGN1P6 LOC100132849
GH02G206081 1.6 Ensembl ENCODE dbSUPER 5.6 +133.6 133631 6.7 FOXA2 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 NDUFS1 ENSG00000231955 GCSHP3 EEF1B2 SNORA41 SNORD51 GPR1 ENSG00000227946 RPL27P8
GH02G206274 1 ENCODE 8.1 -57.2 -57185 2.4 ARNT SIN3A FEZF1 ZNF263 SP3 TBX21 ZNF518A KAT8 CBX8 NR2C1 GPR1 ZDBF2 GC02M206303
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR1 Gene

206,175,316 bp from pter
206,218,047 bp from pter
42,732 bases
Minus strand

Genomic View for GPR1 Gene

Genes around GPR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR1 Gene

Proteins for GPR1 Gene

  • Protein details for GPR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G-protein coupled receptor 1
    Protein Accession:
    Secondary Accessions:
    • A5JUU6
    • A8K4L1
    • Q53TR9
    • Q6NVX4

    Protein attributes for GPR1 Gene

    355 amino acids
    Molecular mass:
    41431 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR1 Gene

Post-translational modifications for GPR1 Gene

  • Glycosylation at posLast=1414
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPR1 Gene

Domains & Families for GPR1 Gene

Gene Families for GPR1 Gene

Protein Domains for GPR1 Gene

Suggested Antigen Peptide Sequences for GPR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR1: view

Function for GPR1 Gene

Molecular function for GPR1 Gene

GENATLAS Biochemistry:
G protein coupled receptor 1,expressed in hippocampus,functioning in a RAS-independent pathway with a large third cytoplasmic loop and a large cytoplasmic tail
UniProtKB/Swiss-Prot Function:
Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation. Can act as a coreceptor for HIV-1.

Gene Ontology (GO) - Molecular Function for GPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS,IBA --
GO:0005515 protein binding IPI 24955142
GO:0042923 neuropeptide binding IBA --
genes like me logo Genes that share ontologies with GPR1: view
genes like me logo Genes that share phenotypes with GPR1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR1

CRISPR Products

miRNA for GPR1 Gene

miRTarBase miRNAs that target GPR1

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR1 Gene

Localization for GPR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR1 gene
Compartment Confidence
plasma membrane 5
extracellular 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for GPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA --
GO:0005887 integral component of plasma membrane TAS 7851889
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043005 neuron projection IBA --
genes like me logo Genes that share ontologies with GPR1: view

Pathways & Interactions for GPR1 Gene

genes like me logo Genes that share pathways with GPR1: view

Pathways by source for GPR1 Gene

1 BioSystems pathway for GPR1 Gene

Gene Ontology (GO) - Biological Process for GPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 7851889
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA --
GO:0007218 neuropeptide signaling pathway IBA --
GO:0007268 chemical synaptic transmission IBA --
genes like me logo Genes that share ontologies with GPR1: view

No data available for SIGNOR curated interactions for GPR1 Gene

Drugs & Compounds for GPR1 Gene

(2) Drugs for GPR1 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
chemerin Pharma Full agonist, Agonist 0
chemerin C-terminal peptide Pharma Agonist 0
genes like me logo Genes that share compounds with GPR1: view

Transcripts for GPR1 Gene

Unigene Clusters for GPR1 Gene

G protein-coupled receptor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: - -
SP2: - -
SP3: - - -
SP4: - - -
SP5: -

Relevant External Links for GPR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR1 Gene

This gene is overexpressed in Vagina (x4.5) and Skin - Sun Exposed (Lower leg) (x4.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR1 Gene

Protein tissue co-expression partners for GPR1 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPR1 Gene:


SOURCE GeneReport for Unigene cluster for GPR1 Gene:


mRNA Expression by UniProt/SwissProt for GPR1 Gene:

Tissue specificity: Expressed in hippocampus.

Evidence on tissue expression from TISSUES for GPR1 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with GPR1: view

Primer Products

No data available for Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR1 Gene

Orthologs for GPR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR1 34 35
  • 99.62 (n)
(Canis familiaris)
Mammalia GPR1 34 35
  • 89.86 (n)
(Bos Taurus)
Mammalia GPR1 34 35
  • 87.61 (n)
(Mus musculus)
Mammalia Gpr1 34 16 35
  • 83.14 (n)
(Rattus norvegicus)
Mammalia Gpr1 34
  • 81.76 (n)
(Ornithorhynchus anatinus)
Mammalia GPR1 35
  • 76 (a)
(Monodelphis domestica)
Mammalia GPR1 35
  • 69 (a)
(Gallus gallus)
Aves GPR1 34 35
  • 68.83 (n)
(Anolis carolinensis)
Reptilia GPR1 35
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr1 34
  • 59.88 (n)
(Danio rerio)
Actinopterygii gpr1 34 35
  • 52.48 (n)
Species where no ortholog for GPR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR1 Gene

Gene Tree for GPR1 (if available)
Gene Tree for GPR1 (if available)

Paralogs for GPR1 Gene

Variants for GPR1 Gene

Sequence variations from dbSNP and Humsavar for GPR1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000055000 -- 206,195,728(+) GGCAG(G/T)CAGAT intron-variant
rs1000071596 -- 206,175,385(+) AAGTA(C/G)ACATG utr-variant-3-prime
rs1000101925 -- 206,176,802(+) GGGTT(C/T)GATGC reference, missense
rs1000205230 -- 206,214,406(+) TGACC(C/T)ACCTC intron-variant, upstream-variant-2KB
rs1000237242 -- 206,177,079(+) GATGG(C/T)ATTTC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for GPR1 Gene

Variant ID Type Subtype PubMed ID
nsv480838 CNV novel sequence insertion 20440878

Variation tolerance for GPR1 Gene

Residual Variation Intolerance Score: 69.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.41; 90.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR1 Gene

Disorders for GPR1 Gene

Relevant External Links for GPR1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GPR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR1 Gene

Publications for GPR1 Gene

  1. Cloning of human genes encoding novel G protein-coupled receptors. (PMID: 7851889) Marchese A. … O'Dowd B.F. (Genomics 1994) 2 3 4 22 64
  2. An orphan G protein-coupled receptor, GPR1, acts as a coreceptor to allow replication of human immunodeficiency virus types 1 and 2 in brain-derived cells. (PMID: 10233994) Shimizu N. … Hoshino H. (J. Virol. 1999) 3 4 22 64
  3. Short communication: identification of the conformational requirement for the specificities of coreceptors for human and simian immunodeficiency viruses. (PMID: 20334567) Shimizu N. … Hoshino H. (AIDS Res. Hum. Retroviruses 2010) 3 22 64
  4. Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size. (PMID: 19343178) Soranzo N. … Deloukas P. (PLoS Genet. 2009) 3 46 64
  5. G protein-coupled receptor for asthma susceptibility associates with respiratory distress syndrome. (PMID: 16938805) Pulkkinen V. … Laitinen T. (Ann. Med. 2006) 3 46 64

Products for GPR1 Gene

  • Addgene plasmids for GPR1

Sources for GPR1 Gene

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