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GPNMB Gene

protein-coding   GIFtS: 61
GCID: GC07P023252

Glycoprotein (Transmembrane) Nmb

  See GPNMB-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glycoprotein (Transmembrane) Nmb1 2     HGFIN2 3
Glycoprotein NMB1 2     NMB2 3
Glycoprotein Nmb-Like Protein1 2     Transmembrane Glycoprotein1
osteoactivin1 2     Transmembrane Glycoprotein NMB2
Transmembrane Glycoprotein HGFIN2 3     

External Ids:    HGNC: 44621   Entrez Gene: 104572   Ensembl: ENSG000001362357   OMIM: 6043685   UniProtKB: Q149563   

Export aliases for GPNMB gene to outside databases

Previous GC identifers: GC07P022928 GC07P022994 GC07P023028 GC07P023059 GC07P023170


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GPNMB Gene:
The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17
precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell
lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in
growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been
found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for GPNMB Gene:
GPNMB (glycoprotein (transmembrane) nmb) is a protein-coding gene. Diseases associated with GPNMB include iris disease. GO annotations related to this gene include integrin binding and heparin binding. An important paralog of this gene is PMEL.

UniProtKB/Swiss-Prot: GPNMB_HUMAN, Q14956
Function: Could be a melanogenic enzyme (By similarity)

summary for GPNMB Gene:
Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B
(NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: a GRP-preferring receptor
(BB1 receptor), a NMB-preferring receptor (BB2 receptor) and an orphan receptor (bb3 receptor). The
receptors are Gq/11-coupled and are involved in the regulation of many biological functions including
sensory transmission, thermoregulation, feeding, pituitary, gastric and pancreatic secretion. They may also
be involved in tissue development, proliferation and differentiation.

Gene Wiki entry for GPNMB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GPNMB gene promoter:
         Bach1   ER-alpha   p53   ARP-1   AP-4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 9): GPNMB promoter sequence
   Search Chromatin IP Primers for GPNMB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GPNMB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15   Ensembl cytogenetic band:  7p15.3   HGNC cytogenetic band: 7p

GPNMB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPNMB gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P023252:  view genomic region     (about GC identifiers)

Start:
23,275,586 bp from pter      End:
23,314,729 bp from pter
Size:
39,144 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 23,338,195-23,366,606     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GPNMB_HUMAN, Q14956 (See protein sequence)
Recommended Name: Transmembrane glycoprotein NMB precursor  
Size: 572 amino acids; 63923 Da
Secondary accessions: A4D155 Q6UVX1 Q8N1A1
Alternative splicing: 2 isoforms:  Q14956-1   Q14956-2   

Explore the universe of human proteins at neXtProt for GPNMB: NX_Q14956

Explore proteomics data for GPNMB at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn93, Asn134, Asn146, Asn200, Asn249, Asn275, Asn296, Asn300, Asn306, Asn312,
                                 Asn459, Asn467
  • Modification sites at PhosphoSitePlus

  • See GPNMB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001005340.1  NP_002501.1  

    ENSEMBL proteins: 
     ENSP00000258733   ENSP00000371420   ENSP00000386476   ENSP00000445266   ENSP00000405586  

    GPNMB Human Recombinant Protein Products:

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    Sino Biological Recombinant Protein for GPNMB
    Sino Biological Cell Lysate for GPNMB
    ProSpec Recombinant Protein for GPNMB
    Cloud-Clone Corp. Proteins for GPNMB

     
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    antibodies-online proteins for GPNMB (10 products) 

     
    antibodies-online peptides for GPNMB

    GPNMB Antibody Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000601 PKD_dom
     IPR022409 PKD/Chitinase_dom

    Graphical View of Domain Structure for InterPro Entry Q14956

    ProtoNet protein and cluster: Q14956

    1 Blocks protein domain: IPB000601 PKD

    UniProtKB/Swiss-Prot: GPNMB_HUMAN, Q14956
    Similarity: Belongs to the PMEL/NMB family
    Similarity: Contains 1 PKD domain


    Find genes that share domains with GPNMB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GPNMB_HUMAN, Q14956
    Function: Could be a melanogenic enzyme (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005178integrin binding IEA--
    GO:0008201heparin binding IEA--
         
    Find genes that share ontologies with GPNMB           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Gpnmb):
     nervous system  pigmentation  vision/eye 

    Find genes that share phenotypes with GPNMB           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for GPNMB

    miRNA
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    miRTarBase miRNAs that target GPNMB:
    hsa-mir-26b-5p (MIRT030247)

    Block miRNA regulation of human, mouse, rat GPNMB using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate GPNMB:
    hsa-miR-3671 hsa-miR-607 hsa-miR-494
    SwitchGear 3'UTR luciferase reporter plasmidGPNMB 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GPNMB_HUMAN, Q14956: Cell membrane; Single-pass type I membrane protein. Melanosome. Note=Identified by mass
    spectrometry in melanosome fractions from stage I to stage IV. Detected at the cell surface in different types of
    cancers cells, including glioblastoma multiforme cells and most melanoma cell lines
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol1
    extracellular1
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane IEA--
    GO:0016021integral component of membrane TAS7814155
    GO:0016023cytoplasmic membrane-bounded vesicle ----
    GO:0042470melanosome IEA--

    Find genes that share ontologies with GPNMB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including GPNMB: 
              Nephrotoxicity in human mouse rat
              Tumor Metastasis in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for GPNMB

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for GPNMB (Q149562, 3 ENSP000003714204) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD4Q134852, 3MINT-61971 I2D: score=3 
    PLA2G4AP477123I2D: score=1 
    ITSN2ENSP000003472444STRING: ENSP00000347244
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001649osteoblast differentiation IEA--
    GO:0007155cell adhesion IEA--
    GO:0008285negative regulation of cell proliferation TAS7814155
    GO:0030282bone mineralization IEA--

    Find genes that share ontologies with GPNMB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for GPNMB available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BombesinInvolved in gastrointestinal tract function[31362-50-2]
    PD 176252GRP (BB2) and NMB (BB1) receptor antagonist[204067-01-6]
    GRP (human)Endogenous GRP receptor agonist[93755-85-2]
    GRP (porcine)Endogenous GRP receptor agonist[74815-57-9]
    Neuromedin B (porcine)Mammalian bombesin-like peptide[87096-84-2]



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GPNMB gene (2 alternative transcripts): 
    NM_001005340.1  NM_002510.2  

    Unigene Cluster for GPNMB:

    Glycoprotein (transmembrane) nmb
    Hs.190495  [show with all ESTs]
    Unigene Representative Sequence: BC032783
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000465673 ENST00000492858 ENST00000258733(uc003swb.3 uc011jyz.2)
    ENST00000381990(uc003swc.3 uc011jyy.2) ENST00000409458(uc003swa.2)
    ENST00000459927 ENST00000487890 ENST00000474157 ENST00000492512 ENST00000479625
    ENST00000470994 ENST00000463011 ENST00000478451 ENST00000468723 ENST00000539136
    ENST00000453162
    miRNA
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    hsa-miR-3671 hsa-miR-607 hsa-miR-494
    SwitchGear 3'UTR luciferase reporter plasmidGPNMB 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): GPNMB (NM_002510)
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      QuantiFast Probe-based Assays in human, mouse, rat GPNMB
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-14052) for GPNMB 

    Additional mRNA sequence: 

    AF322909.1 AJ505015.1 AK292078.1 AK296779.1 AK297031.1 AK297051.1 AK297055.1 AK297803.1 
    AK303071.1 AK304671.1 AK312279.1 AY359124.1 BC011595.1 BC025297.1 BC032783.1 BT007074.1 
    X76534.1 

    Selected DOTS entries (see all 41):

    DT.447521  DT.101984417  DT.100770181  DT.100808120  DT.121095463  DT.100886002  DT.100886005  DT.121095465 
    DT.100885999  DT.100886006  DT.100038720  DT.121095475  DT.419207  DT.97847404  DT.121095449  DT.92416173 
    DT.95156153  DT.65284497  DT.100038718  DT.100038717  DT.91700495  DT.121095473  DT.121095504  DT.121095539 

    Selected AceView cDNA sequences (see all 636):

    BU675600 AW627387 BC011595 AY359124 BU676763 AL044825 BC032783 CA429985 
    AI818459 CB266181 CB216233 AA367930 BE551378 BQ894073 BI793175 AA771879 
    W74703 CA417410 NM_002510 CK824606 AI346082 BE714423 AU136173 BM547872 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GPNMB (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^
    SP1:                          -     -                                                                 -                                   -     -               
    SP2:                          -     -                                                                 -                                   -                     
    SP3:                                                                                                                                      -                     
    SP4:                          -     -                 -     -     -     -     -     -                 -                                                         
    SP5:                          -     -                                         -     -     -     -     -                                                         

    ExUns: 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c · 15d · 15e
    SP1:              -     -           -                           
    SP2:              -     -           -                           
    SP3:              -     -                                       
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for GPNMB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GPNMB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACATTCTTTT
    GPNMB Expression
    About this image


    GPNMB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Zeugopod Periosteum
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem MEL2, NCr-fac Progenitor
     
     Ovary (Reproductive System)
             Mature follicles
     
     Epithelial Cells
             Fetal Matrix Cells Hair Follicle
     
     Mesoderm (Gastrulation Derivatives)
             PureStem 7SMOO32, NCr-fac & Meso Progenitor
    GPNMB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GPNMB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.190495

    UniProtKB/Swiss-Prot: GPNMB_HUMAN, Q14956
    Tissue specificity: Up-regulated in various cancer cells, including in glioblastoma multiforme. Expressed in many
    melanoma cells, as well as in tissue macrophages, including liver Kuppfer cells and lung alveolar macrophages, in
    podocytes and in some cells of the ciliary body of the eye (at protein level). Hardly detectable in healthy brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GPNMB: 
              Nephrotoxicity in human mouse rat
              Tumor Metastasis in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPNMB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for GPNMB gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpnmb1 , 5 glycoprotein (transmembrane) nmb1, 5 76.85(n)1
    70.34(a)1
      6 (23.82 cM)5
    936951  NM_053110.41  NP_444340.31 
     490365185 
    chicken
    (Gallus gallus)
    Aves GPNMB1 glycoprotein (transmembrane) nmb 61.92(n)
    54.12(a)
      428431  XM_425991.3  XP_425991.2 
    lizard
    (Anolis carolinensis)
    Reptilia GPNMB6
    glycoprotein (transmembrane) nmb
    50(a)
    1 ↔ 1
    6(30459487-30487867)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.69132 Xenopus laevis transcribed sequence with weak similarity more 72.52(n)    BU901029.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gpnmb1 glycoprotein (transmembrane) nmb 48.8(n)
    38.19(a)
      563348  XM_686712.6  XP_691804.2 


    ENSEMBL Gene Tree for GPNMB (if available)
    TreeFam Gene Tree for GPNMB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GPNMB gene
    PMEL2  
    1 SIMAP similar gene for GPNMB using alignment to 5 protein entries:     GPNMB_HUMAN (see all proteins):
    PMEL

    Find genes that share paralogs with GPNMB           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GPNMB (see all 830)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0362634
    A breast cancer sample4--see VAR_0362632 S I mis40--------
    VAR_0362624
    A breast cancer sample4--see VAR_0362622 A D mis40--------
    rs749632071,2
    C,F--23284365(+) AGGGAA/GGGAAA 2 -- us2k12Minor allele frequency- G:0.03CSA WA 120
    rs1499081351,2
    --23284417(+) AAAACC/GAAGGT 2 -- us2k10--------
    rs69712441,2
    C,F,A,H--23284443(+) TTTAAC/AACTTC 2 -- us2k17Minor allele frequency- A:0.09NS EA CSA WA 660
    rs69712491,2
    C,F,H--23284464(+) AGAGAC/TGGGGT 2 -- us2k17Minor allele frequency- T:0.08NS EA CSA WA 658
    rs1477089341,2
    C--23284465(+) GAGACA/GGGGTG 2 -- us2k10--------
    rs1814499391,2
    --23284490(+) AAATAA/TGAGCC 2 -- us2k10--------
    rs1425409091,2
    --23284545(+) TAATAA/GTAGCT 2 -- us2k10--------
    rs1861348051,2
    --23284581(+) TTTTTA/TATTGT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for GPNMB (23275586 - 23314729 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for GPNMB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5661CNV Insertion18451855
    nsv887840CNV Loss21882294
    nsv520600CNV Loss19592680
    nsv7393OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GPNMB
    DNA2.0 Custom Variant and Variant Library Synthesis for GPNMB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604368    OMIM disorders: --

    UniProtKB/Swiss-Prot: GPNMB_HUMAN, Q14956
  • Note=Glioblastoma multiforme patients that exhibit increased mRNA and protein levels (>3-fold over normal
    brain) in biopsy samples have a significantly higher risk of death (PubMed:16609006). In the context of cancer
    immunotherapy, including that of melanoma, has been proposed to be used as a cell surface protein antigen
    targeted by antibodies coupled to cytotoxic drugs (PubMed:16489096)

  • 1 disease for GPNMB:    
    About MalaCards
    iris disease

    3 diseases from the University of Copenhagen DISEASES database for GPNMB:
    Glaucoma     Melanoma     Iris disease

    Find genes that share disorders with GPNMB           About GenesLikeMe

    3 Novoseek inferred disease relationships for GPNMB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastatic melanoma 50.6 3 16489096 (1), 7814155 (1)
    melanoma 30.4 4 20056711 (2), 16489096 (1), 7814155 (1)
    tumors 5.81 6 17845721 (2), 15684612 (1), 20215530 (1), 7814155 (1)

    Genetic Association Database (GAD): GPNMB
    Human Genome Epidemiology (HuGE) Navigator: GPNMB (4 documents)

    Export disorders for GPNMB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GPNMB gene, integrated from 10 sources (see all 49):
    (articles sorted by number of sources associating them with GPNMB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NMB, a novel gene, is expressed in low-metastatic human melanoma cell lines and xenografts. (PubMed id 7814155)1, 2, 3, 9 Weterman M.A.J.... Bloemers H.P.J. (Int. J. Cancer 1995)
    2. Hematopoietic growth factor inducible neurokinin-1 type: a transmembrane protein that is similar to neurokinin 1 interacts with substance P. (PubMed id 12609765)1, 2, 9 Bandari P.S.... Rameshwar P. (Regul. Pept. 2003)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (PLoS Genet. 2009)
    5. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    6. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (J. Proteome Res. 2006)
    7. Glycoprotein nonmetastatic melanoma protein B, a potential molecular therapeutic target in patients with glioblastoma multiforme. (PubMed id 16609006)1, 2 Kuan C.T.... Bigner D.D. (Clin. Cancer Res. 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    10. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10457 HGNC: 4462 AceView: GPNMB Ensembl:ENSG00000136235 euGenes: HUgn10457
    ECgene: GPNMB H-InvDB: GPNMB

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for GPNMB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GPNMB Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GPNMB gene:
    Search GeneIP for patents involving GPNMB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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