Aliases for GPNMB Gene
External Ids for GPNMB Gene
Previous GeneCards Identifiers for GPNMB Gene
The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for GPNMB Gene
GPNMB (Glycoprotein Nmb) is a Protein Coding gene. Diseases associated with GPNMB include melanoma and glioblastoma multiforme. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include heparin binding and integrin binding. An important paralog of this gene is PMEL.
UniProtKB/Swiss-Prot for GPNMB Gene
Could be a melanogenic enzyme.