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Aliases for GPN3 Gene

Aliases for GPN3 Gene

  • GPN-Loop GTPase 3 2 3
  • ATP Binding Domain 1 Family, Member C 2 3
  • ATP-Binding Domain 1 Family Member C 3 4
  • ATPBD1C 3 4
  • Protein X 0004 3

External Ids for GPN3 Gene

Previous HGNC Symbols for GPN3 Gene

  • ATPBD1C

Previous GeneCards Identifiers for GPN3 Gene

  • GC12M109374
  • GC12M110890
  • GC12M107908

Summaries for GPN3 Gene

GeneCards Summary for GPN3 Gene

GPN3 (GPN-Loop GTPase 3) is a Protein Coding gene. GO annotations related to this gene include nucleotide binding and hydrolase activity.

UniProtKB/Swiss-Prot for GPN3 Gene

  • Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.

Gene Wiki entry for GPN3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPN3 Gene

Genomics for GPN3 Gene

Regulatory Elements for GPN3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GPN3 Gene

Chromosome:
12
Start:
110,452,484 bp from pter
End:
110,469,268 bp from pter
Size:
16,785 bases
Orientation:
Minus strand

Genomic View for GPN3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPN3 Gene

Proteins for GPN3 Gene

  • Protein details for GPN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHW5-GPN3_HUMAN
    Recommended name:
    GPN-loop GTPase 3
    Protein Accession:
    Q9UHW5
    Secondary Accessions:
    • B2RC54
    • D4YWV1
    • F5H759
    • Q53FS3
    • Q6UVZ6
    • Q7Z3D3
    • Q8NEI2
    • Q96HK9

    Protein attributes for GPN3 Gene

    Size:
    284 amino acids
    Molecular mass:
    32761 Da
    Quaternary structure:
    • Heterodimer with GPN1 (PubMed:21768307). Binds to RNA polymerase II (RNAPII) (PubMed:20864038, PubMed:21768307). Interacts directly with subunits RPB4 and RPB7 and the CTD of RPB1 (PubMed:21768307).
    SequenceCaution:
    • Sequence=CAD97937.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for GPN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPN3 Gene

Proteomics data for GPN3 Gene at MOPED

Post-translational modifications for GPN3 Gene

  • Ubiquitination at Lys 16 and Lys 216
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPN3 Gene

Domains & Families for GPN3 Gene

Gene Families for GPN3 Gene

Protein Domains for GPN3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPN3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UHW5

UniProtKB/Swiss-Prot:

GPN3_HUMAN :
  • Belongs to the GPN-loop GTPase family.
Family:
  • Belongs to the GPN-loop GTPase family.
genes like me logo Genes that share domains with GPN3: view

Function for GPN3 Gene

Molecular function for GPN3 Gene

UniProtKB/Swiss-Prot Function:
Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.

Gene Ontology (GO) - Molecular Function for GPN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IPI 25241168
GO:0005525 GTP binding IEA --
GO:0016787 hydrolase activity --
genes like me logo Genes that share ontologies with GPN3: view
genes like me logo Genes that share phenotypes with GPN3: view

Animal Model Products

CRISPR Products

miRNA for GPN3 Gene

miRTarBase miRNAs that target GPN3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPN3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GPN3 Gene

Localization for GPN3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPN3 Gene COMPARTMENTS Subcellular localization image for GPN3 gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for GPN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043234 protein complex IDA --
genes like me logo Genes that share ontologies with GPN3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GPN3 Gene

Pathways & Interactions for GPN3 Gene

SuperPathways for GPN3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with GPN3: view

No data available for Pathways by source and SIGNOR curated interactions for GPN3 Gene

Drugs & Compounds for GPN3 Gene

No Compound Related Data Available

Transcripts for GPN3 Gene

Unigene Clusters for GPN3 Gene

GPN-loop GTPase 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPN3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPN3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
SP1: - -
SP2: -
SP3:
SP4:

Relevant External Links for GPN3 Gene

GeneLoc Exon Structure for
GPN3
ECgene alternative splicing isoforms for
GPN3

Expression for GPN3 Gene

mRNA expression in normal human tissues for GPN3 Gene

Protein differential expression in normal tissues from HIPED for GPN3 Gene

This gene is overexpressed in Bone (16.5), Peripheral blood mononuclear cells (11.1), and Testis (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GPN3 Gene



SOURCE GeneReport for Unigene cluster for GPN3 Gene Hs.634680

genes like me logo Genes that share expression patterns with GPN3: view

Protein tissue co-expression partners for GPN3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GPN3 Gene

Orthologs for GPN3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPN3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPN3 35
  • 93.08 (n)
  • 96.83 (a)
GPN3 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPN3 35
  • 92.72 (n)
  • 97.89 (a)
GPN3 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpn3 35
  • 85.21 (n)
  • 94.72 (a)
Gpn3 16
Gpn3 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPN3 35
  • 99.88 (n)
  • 100 (a)
GPN3 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpn3 35
  • 86.62 (n)
  • 96.13 (a)
oppossum
(Monodelphis domestica)
Mammalia GPN3 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPN3 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPN3 35
  • 78.4 (n)
  • 86.62 (a)
GPN3 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPN3 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpn3 35
  • 78.17 (n)
  • 85.21 (a)
Str.15832 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.10460 35
zebrafish
(Danio rerio)
Actinopterygii gpn3 35
  • 75.27 (n)
  • 84.45 (a)
gpn3 36
  • 80 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001152 35
  • 58.03 (n)
  • 55.84 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2656 35
  • 60.71 (n)
  • 56.27 (a)
CG2656 36
  • 50 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_Y75B8A.14 35
  • 56.39 (n)
  • 53.76 (a)
Y75B8A.14 36
  • 50 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL117C 35
  • 53.94 (n)
  • 46.56 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D18557g 35
  • 53.87 (n)
  • 47.15 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GPN3 35
  • 54.01 (n)
  • 43.98 (a)
-- 36
  • 40 (a)
OneToOne
-- 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G12790 35
  • 59.97 (n)
  • 53.01 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.2697 35
rice
(Oryza sativa)
Liliopsida Os.11878 35
Os03g0337700 35
  • 59.16 (n)
  • 55.34 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4433 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02658 35
  • 54.81 (n)
  • 47.19 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes fet5 35
  • 53.41 (n)
  • 46.21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2812 36
  • 55 (a)
OneToOne
Species with no ortholog for GPN3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPN3 Gene

ENSEMBL:
Gene Tree for GPN3 (if available)
TreeFam:
Gene Tree for GPN3 (if available)

Paralogs for GPN3 Gene

(2) SIMAP similar genes for GPN3 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for GPN3 Gene

genes like me logo Genes that share paralogs with GPN3: view

No data available for Paralogs for GPN3 Gene

Variants for GPN3 Gene

Sequence variations from dbSNP and Humsavar for GPN3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs6606686 -- 110,465,575(+) ACAGT(C/G)CAAAC intron-variant
rs7135521 -- 110,461,913(+) catgg(A/C)tcact intron-variant
rs7306167 -- 110,454,644(+) actgc(A/G)cACCT intron-variant
rs7315600 -- 110,460,858(+) actcc(A/G)gaggc intron-variant
rs9737712 -- 110,463,521(+) tccca(A/G)cactt intron-variant

Variation tolerance for GPN3 Gene

Residual Variation Intolerance Score: 30.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.58; 30.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPN3 Gene

HapMap Linkage Disequilibrium report
GPN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GPN3 Gene

Disorders for GPN3 Gene

Relevant External Links for GPN3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPN3
genes like me logo Genes that share disorders with GPN3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPN3 Gene

Publications for GPN3 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Gpn1 and Gpn3 associate tightly and their protein levels are mutually dependent in mammalian cells. (PMID: 25241168) MAcndez-HernA!ndez L.E. … Calera M.R. (FEBS Lett. 2014) 67
  4. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 67
  5. Human GTPases associate with RNA polymerase II to mediate its nuclear import. (PMID: 21768307) CarrAc C. … Shiekhattar R. (Mol. Cell. Biol. 2011) 67

Products for GPN3 Gene

Sources for GPN3 Gene

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