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Aliases for GPN2 Gene

Aliases for GPN2 Gene

  • GPN-Loop GTPase 2 2 3
  • ATP Binding Domain 1 Family, Member B 2 3
  • ATP-Binding Domain 1 Family Member B 3 4
  • ATPBD1B 3 4

External Ids for GPN2 Gene

Previous Symbols for GPN2 Gene

  • ATPBD1B

Summaries for GPN2 Gene

GeneCards Summary for GPN2 Gene

GPN2 (GPN-Loop GTPase 2) is a Protein Coding gene. GO annotations related to this gene include GTP binding.

UniProtKB/Swiss-Prot for GPN2 Gene

  • Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPN2 Gene

Genomics for GPN2 Gene

Genomic Location for GPN2 Gene

Start:
26,876,133 bp from pter
End:
26,890,378 bp from pter
Size:
14,246 bases
Orientation:
Minus strand

Genomic View for GPN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPN2 Gene

Regulatory Elements for GPN2 Gene

Proteins for GPN2 Gene

  • Protein details for GPN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9Y4-GPN2_HUMAN
    Recommended name:
    GPN-loop GTPase 2
    Protein Accession:
    Q9H9Y4
    Secondary Accessions:
    • Q96HG4
    • Q9NUE1
    • Q9NW30

    Protein attributes for GPN2 Gene

    Size:
    310 amino acids
    Molecular mass:
    34561 Da
    Quaternary structure:
    • Heterodimers with GPN1 or GPN3 (By similarity). Binds to RNA polymerase II (RNAPII) (PubMed:20864038).

neXtProt entry for GPN2 Gene

Proteomics data for GPN2 Gene at MOPED

Post-translational modifications for GPN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPN2 Gene

Domains for GPN2 Gene

Gene Families for GPN2 Gene

HGNC:
  • GPN :GPN-loop GTPases

Protein Domains for GPN2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H9Y4

UniProtKB/Swiss-Prot:

GPN2_HUMAN
Family:
  • Belongs to the GPN-loop GTPase family.:
    • Q9H9Y4
genes like me logo Genes that share domains with GPN2: view

Function for GPN2 Gene

Molecular function for GPN2 Gene

UniProtKB/Swiss-Prot Function: Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

Gene Ontology (GO) - Molecular Function for GPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0003674 molecular_function ND --
GO:0005525 GTP binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with GPN2: view

miRNA for GPN2 Gene

miRTarBase miRNAs that target GPN2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for GPN2 Gene

Localization for GPN2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPN2 Gene COMPARTMENTS Subcellular localization image for GPN2 gene
Compartment Confidence
mitochondrion 2
cytosol 1
endoplasmic reticulum 1
lysosome 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for GPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with GPN2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GPN2 Gene

Pathways for GPN2 Gene

SuperPathways for GPN2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with GPN2: view

No data available for Pathways by source for GPN2 Gene

Transcripts for GPN2 Gene

Unigene Clusters for GPN2 Gene

GPN-loop GTPase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPN2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - - -
SP2: -
SP3: -
SP4:

Relevant External Links for GPN2 Gene

GeneLoc Exon Structure for
GPN2
ECgene alternative splicing isoforms for
GPN2

Expression for GPN2 Gene

mRNA expression in normal human tissues for GPN2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GPN2 Gene

SOURCE GeneReport for Unigene cluster for GPN2 Gene Hs.14333

genes like me logo Genes that share expressions with GPN2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GPN2 Gene

Orthologs for GPN2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPN2 35
  • 99.57 (n)
  • 99.68 (a)
GPN2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GPN2 35
  • 91.51 (n)
  • 97.42 (a)
GPN2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPN2 35
  • 91.61 (n)
  • 97.74 (a)
GPN2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpn2 35
  • 90.97 (n)
  • 96.13 (a)
Gpn2 16
Gpn2 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPN2 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPN2 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpn2 35
  • 89.46 (n)
  • 95.48 (a)
chicken
(Gallus gallus)
Aves GPN2 35
  • 76.22 (n)
  • 74.59 (a)
GPN2 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPN2 36
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398460 35
tropical clawed frog
(Silurana tropicalis)
Amphibia gpn2 35
  • 66.43 (n)
  • 65.49 (a)
Str.498 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5769 35
zebrafish
(Danio rerio)
Actinopterygii Dr.19021 35
gpn2 35
  • 70 (n)
  • 71.29 (a)
gpn2 36
  • 71 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003193 35
  • 60.32 (n)
  • 51.28 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10222 35
  • 58 (n)
  • 52.75 (a)
CG10222 36
  • 46 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea B0207.6 36
  • 42 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL117C 35
  • 56.24 (n)
  • 49.42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 38 (a)
OneToOne
-- 38
GPN2 35
  • 52.71 (n)
  • 48.84 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C09504g 35
  • 51.42 (n)
  • 47.29 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1085 35
thale cress
(Arabidopsis thaliana)
eudicotyledons QQT1 35
  • 55.32 (n)
  • 56.6 (a)
corn
(Zea mays)
Liliopsida Zm.4543 35
rice
(Oryza sativa)
Liliopsida Os.5253 35
Os02g0555000 35
  • 59.72 (n)
  • 56.94 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09745 35
  • 54.14 (n)
  • 43.62 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC144.07c 35
  • 48.32 (n)
  • 44.57 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7378 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10206 36
  • 57 (a)
OneToOne
Species with no ortholog for GPN2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPN2 Gene

ENSEMBL:
Gene Tree for GPN2 (if available)
TreeFam:
Gene Tree for GPN2 (if available)

Paralogs for GPN2 Gene

Selected SIMAP similar genes for GPN2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GPN2: view

No data available for Paralogs for GPN2 Gene

Variants for GPN2 Gene

Sequence variations from dbSNP and Humsavar for GPN2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs11568 -- 26,884,264(-) GTCCT(G/T)CAGGC reference, synonymous-codon
rs910048 -- 26,889,293(-) AAAAA(A/G)ATGAC intron-variant
rs1045460 -- 26,879,463(-) GAGCT(C/T)TGGGC utr-variant-3-prime
rs2294876 -- 26,879,481(-) ACTGT(C/T)AGTGG utr-variant-3-prime
rs3170660 - 26,884,230(-) GTTTC(A/G)GAGCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for GPN2 Gene

Variant ID Type Subtype PubMed ID
nsv834524 CNV Gain+Loss 17160897

Relevant External Links for GPN2 Gene

HapMap Linkage Disequilibrium report
GPN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPN2 Gene

Disorders for GPN2 Gene

No disorders were found for GPN2 Gene.

No data available for UniProtKB/Swiss-Prot for GPN2 Gene

Publications for GPN2 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for GPN2 Gene

Sources for GPN2 Gene

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