GPN2 Gene
protein-coding GIFtS: 46
GCID: GC01M027205
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|
GPN-loop GTPase 2(Previous names: ATP binding domain 1 family, member B )
(Previous symbol: ATPBD1B)
| |
Aliases
for GPN2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| GPN-Loop GTPase 21 2 | | ATPBD1B1 2 3 | | ATP Binding Domain 1 Family, Member B1 2 | | ATP-Binding Domain 1 Family Member B2 3 | | FLJ103491 |
Export aliases for GPN2 gene to outside databasesPrevious GC identifers: GC01M027079 GC01M025460 |
Summaries
for GPN2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for GPN2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GPN2 gene promoter:
USF1 NF-1 USF2 RelA USF-1:USF-2 NF-kappaB Arnt c-Rel USF-1 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for GPN2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPN2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.11 Ensembl cytogenetic band: 1p36.11 HGNC cytogenetic band: 1p36.11GPN2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M027205: view genomic region
(about GC identifiers)
Start:
|
27,205,773 bp from pter |
End:
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27,216,869 bp from pter |
Size:
|
11,097 bases |
Orientation:
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minus strand |
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Proteins
for GPN2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GPN2_HUMAN, Q9H9Y4 (See
protein sequence)Recommended Name: GPN-loop GTPase 2 Size: 310 amino acids; 34561 Da
Secondary accessions: Q96HG4 Q9NUE1 Q9NW30Explore the universe of human proteins at neXtProt for GPN2: NX_Q9H9Y4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H9Y4
GPN2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060536.3
ENSEMBL proteins: ENSP00000363250 ENSP00000363248 ENSP00000408257
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
GPN2 for ontologies About GeneDecksing
GPN2 Antibody Products:
Assay Products for GPN2: |
Protein
Domains /
Families
for GPN2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GPN2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9H9Y4ProtoNet protein and cluster: Q9H9Y4 UniProtKB/Swiss-Prot: GPN2_HUMAN, Q9H9Y4Similarity: Belongs to the GPN-loop GTPase family |
Function
for GPN2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPN2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPN2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: GPN2 (NM_018066) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GPN2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPN2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPN2 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
GPN2 for ontologies About GeneDecksing
|
Pathways & Interactions
for GPN2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GPN2
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
5/7 Interacting proteins for GPN2 (Q9H9Y43 ENSP000003632504) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
GPN2 for ontologies About GeneDecksing
|
Drugs & Compounds
for GPN2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for GPN2
Search CenterWatch for drugs/clinical trials and news about GPN2
|
Transcripts
for GPN2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GPN2 gene: NM_018066.3 Unigene Cluster for GPN2: GPN-loop GTPase 2 Hs.14333 [show with all ESTs]Unigene Representative Sequence: BM9283915 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000374135(uc001bnd.1) ENST00000374133 ENST00000477418 ENST00000431781
ENST00000461282
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPN2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPN2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: GPN2 (NM_018066) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GPN2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPN2 |
Additional cDNA sequence: AK001211.1 AK022535.1 AY364261.1 BC007815.2 BC008634.1 BC020272.1 12 DOTS entries: DT.91948932 DT.100028356 DT.454821 DT.121392823 DT.87046296 DT.121392845 DT.100824769 DT.95114485 DT.101956345 DT.121392757 DT.121392814 DT.100824770 24/411 AceView cDNA sequences (see all 411): CA772087 AL560053 AA047701 BM838545 AA427451 AI697940 BE302432 BI768444 CR601046 BU185178 AA421592 BX452648 BM563313 BG765947 AL833886 BC007767 BG150314 AW157491 AA749225 BQ671565 BQ050678 AI247869 BU944588 CF122903
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for GPN2 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c |
|---|
|
| SP1: | | | | | - | | | | | | - | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for GPN2
|
Expression
for GPN2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GPN2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGCCAAGCA
About this image
See GPN2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GPN2
SOURCE GeneReport for Unigene cluster: Hs.14333
SABiosciences Custom PCR Arrays for GPN2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GPN2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GPN2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPN2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPN2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPN2 |
Orthologs
for GPN2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for GPN2 gene from 9/38 species (see all 38) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
GPN21 |
GPN-loop GTPase 2 |
76.22(n)
74.59(a) |
|
419576 XM_417724.3 XP_417724.3 |
lizard
(Anolis carolinensis) |
Reptilia |
GPN26 |
-- |
65(a) |
1 ↔ 1 |
GL343488.1(166229-170165) |
African clawed frog
(Xenopus laevis) |
Amphibia |
LOC3984602 |
hypothetical protein LOC398460 |
73.64(n) |
|
BC041519.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.190212 |
Transcribed sequence with moderate similarity to protein more |
76.03(n) |
|
CK398030.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG102221 |
CG10222 |
58(n)
52.75(a) |
|
39504 NM_140384.2 NP_648641.2 |
worm
(Caenorhabditis elegans) |
Secernentea |
B0207.66 |
Protein B0207.6 |
42(a) |
1 ↔ 1 |
I(5935372-5936946) |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
(YOR262W)4
YOR262W1 |
Protein of unknown function required for establishment more4
hypothetical protein1 |
52.71(n)1
48.84(a)1 |
|
15(817292-818335)4
8544361, 4 NP_014905.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
QQT11 |
putative purine nucleotide binding protein |
55.4(n)
56.79(a) |
|
832298 NM_001125789.1 NP_001119261.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.52532 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
71.4(n) |
|
AK121253.1 |
ENSEMBL Gene Tree for GPN2 (if available)
TreeFam Gene Tree for GPN2 (if available) |
Paralogs
for GPN2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for GPN2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GPN2 (27205773 - 27216869 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for GPN2
1 CNV: 4218 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GPN2 |
|
Disorders
/ Diseases
for GPN2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GPN2 for disorders About GeneDecksing
3  diseases for GPN2: About MalaCardstinea cruris pityriasis versicolor malaria
Export disorders for GPN2 gene to outside databases
|
Publications
for GPN2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GPN2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with GPN2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- NovelFam3000 -- uncharacterized human protein domains conserved across model organisms. (PubMed id 16533400)2 Kemmer D.... Wasserman W.W. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for GPN2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GPN2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GPN2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GPN2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GPN2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for GPN2 gene:
Search GeneIP for patents involving GPN2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GPN2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for GPN2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GPN2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GPN2 | | | OriGene Protein Over-expression Lysate for GPN2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for GPN2 | | OriGene 3'-UTR Clone for GPN2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPN2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPN2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for GPN2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GPN2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GPN2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPN2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GPN2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPN2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPN2 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for GPN2 |
| |  |  |  |  | | | | |
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 | | | GPN2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPN2 |
|  |  |  | | | | ThermoFisher Antibodies for GPN2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPN2 |
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