Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GPN2 Gene

Aliases for GPN2 Gene

  • GPN-Loop GTPase 2 2 3 5
  • ATP Binding Domain 1 Family, Member B 2 3
  • ATP-Binding Domain 1 Family Member B 3 4
  • ATPBD1B 3 4

External Ids for GPN2 Gene

Previous HGNC Symbols for GPN2 Gene


Previous GeneCards Identifiers for GPN2 Gene

  • GC01M027079
  • GC01M027205
  • GC01M025460

Summaries for GPN2 Gene

GeneCards Summary for GPN2 Gene

GPN2 (GPN-Loop GTPase 2) is a Protein Coding gene. GO annotations related to this gene include nucleotide binding and hydrolase activity.

UniProtKB/Swiss-Prot for GPN2 Gene

  • Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPN2 Gene

Genomics for GPN2 Gene

Regulatory Elements for GPN2 Gene

Enhancers for GPN2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPN2 on UCSC Golden Path with GeneCards custom track

Promoters for GPN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPN2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPN2 Gene

26,876,133 bp from pter
26,890,378 bp from pter
14,246 bases
Minus strand

Genomic View for GPN2 Gene

Genes around GPN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPN2 Gene

Proteins for GPN2 Gene

  • Protein details for GPN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GPN-loop GTPase 2
    Protein Accession:
    Secondary Accessions:
    • Q96HG4
    • Q9NUE1
    • Q9NW30

    Protein attributes for GPN2 Gene

    310 amino acids
    Molecular mass:
    34561 Da
    Quaternary structure:
    • Heterodimers with GPN1 or GPN3 (By similarity). Binds to RNA polymerase II (RNAPII) (PubMed:20864038).

neXtProt entry for GPN2 Gene

Proteomics data for GPN2 Gene at MOPED

Post-translational modifications for GPN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPN2 Gene

Domains & Families for GPN2 Gene

Gene Families for GPN2 Gene

Protein Domains for GPN2 Gene


Suggested Antigen Peptide Sequences for GPN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GPN-loop GTPase family.
  • Belongs to the GPN-loop GTPase family.
genes like me logo Genes that share domains with GPN2: view

Function for GPN2 Gene

Molecular function for GPN2 Gene

UniProtKB/Swiss-Prot Function:
Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

Gene Ontology (GO) - Molecular Function for GPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with GPN2: view

Phenotypes for GPN2 Gene

GenomeRNAi human phenotypes for GPN2:
genes like me logo Genes that share phenotypes with GPN2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPN2 Gene

Localization for GPN2 Gene

Subcellular locations from

Jensen Localization Image for GPN2 Gene COMPARTMENTS Subcellular localization image for GPN2 gene
Compartment Confidence
mitochondrion 2
cytosol 1
endoplasmic reticulum 1
lysosome 1
nucleus 1
peroxisome 1
plasma membrane 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GPN2 Gene

Pathways & Interactions for GPN2 Gene

SuperPathways for GPN2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with GPN2: view

No data available for Pathways by source and SIGNOR curated interactions for GPN2 Gene

Drugs & Compounds for GPN2 Gene

No Compound Related Data Available

Transcripts for GPN2 Gene

Unigene Clusters for GPN2 Gene

GPN-loop GTPase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPN2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - - -
SP2: -
SP3: -

Relevant External Links for GPN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPN2 Gene

mRNA expression in normal human tissues for GPN2 Gene

Protein differential expression in normal tissues from HIPED for GPN2 Gene

This gene is overexpressed in Bone (64.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GPN2 Gene

SOURCE GeneReport for Unigene cluster for GPN2 Gene Hs.14333

genes like me logo Genes that share expression patterns with GPN2: view

Protein tissue co-expression partners for GPN2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GPN2 Gene

Orthologs for GPN2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPN2 35
  • 91.51 (n)
  • 97.42 (a)
GPN2 36
  • 97 (a)
(Canis familiaris)
Mammalia GPN2 35
  • 91.61 (n)
  • 97.74 (a)
GPN2 36
  • 98 (a)
(Mus musculus)
Mammalia Gpn2 35
  • 90.97 (n)
  • 96.13 (a)
Gpn2 16
Gpn2 36
  • 96 (a)
(Pan troglodytes)
Mammalia GPN2 35
  • 99.57 (n)
  • 99.68 (a)
GPN2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Gpn2 35
  • 89.46 (n)
  • 95.48 (a)
(Monodelphis domestica)
Mammalia GPN2 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia GPN2 36
  • 79 (a)
(Gallus gallus)
Aves GPN2 35
  • 76.22 (n)
  • 74.59 (a)
GPN2 36
  • 73 (a)
(Anolis carolinensis)
Reptilia GPN2 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpn2 35
  • 66.43 (n)
  • 65.49 (a)
Str.498 35
African clawed frog
(Xenopus laevis)
Amphibia LOC398460 35
(Danio rerio)
Actinopterygii Dr.19021 35
gpn2 35
  • 70 (n)
  • 71.29 (a)
gpn2 36
  • 71 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5769 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003193 35
  • 60.32 (n)
  • 51.28 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10222 35
  • 58 (n)
  • 52.75 (a)
CG10222 36
  • 46 (a)
(Caenorhabditis elegans)
Secernentea B0207.6 36
  • 42 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL117C 35
  • 56.24 (n)
  • 49.42 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C09504g 35
  • 51.42 (n)
  • 47.29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GPN2 35
  • 52.71 (n)
  • 48.84 (a)
-- 36
  • 38 (a)
GPN2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons QQT1 35
  • 55.32 (n)
  • 56.6 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1085 35
(Oryza sativa)
Liliopsida Os.5253 35
Os02g0555000 35
  • 59.72 (n)
  • 56.94 (a)
(Zea mays)
Liliopsida Zm.4543 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7378 35
bread mold
(Neurospora crassa)
Ascomycetes NCU09745 35
  • 54.14 (n)
  • 43.62 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC144.07c 35
  • 48.32 (n)
  • 44.57 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10206 36
  • 57 (a)
Species with no ortholog for GPN2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPN2 Gene

Gene Tree for GPN2 (if available)
Gene Tree for GPN2 (if available)

Paralogs for GPN2 Gene

(1) SIMAP similar genes for GPN2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GPN2: view

No data available for Paralogs for GPN2 Gene

Variants for GPN2 Gene

Sequence variations from dbSNP and Humsavar for GPN2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs17856257 - 26,886,022(+) TGAGC(C/T)GCACT downstream-variant-500B, reference, missense
rs3170660 - 26,884,230(-) GTTTC(A/G)GAGCC reference, missense
rs11568 -- 26,884,264(-) GTCCT(G/T)CAGGC reference, synonymous-codon
rs910048 -- 26,889,293(-) AAAAA(A/G)ATGAC intron-variant
rs1045460 -- 26,879,463(+) GAGCT(A/C/G/T)TGGGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GPN2 Gene

Variant ID Type Subtype PubMed ID
nsv834524 CNV Gain+Loss 17160897

Variation tolerance for GPN2 Gene

Residual Variation Intolerance Score: 40.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.45; 43.05% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GPN2 Gene

Disorders for GPN2 Gene

Relevant External Links for GPN2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GPN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPN2 Gene

Publications for GPN2 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for GPN2 Gene

Sources for GPN2 Gene