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GPN1 Gene

protein-coding   GIFtS: 52
GCID: GC02P027821

GPN-Loop GTPase 1

(Previous names: XPA binding protein 1, XPA binding protein 1, GTPase)
(Previous symbol: XAB1)
  Search for GPN1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
GPN-Loop GTPase 11 2     ATPBD1A2
XAB11 2 3 5     NTPBP2
MBDIN2 3 5     RPAP42
XPA Binding Protein 1, GTPase1 2     ATP(GTP)-Binding Protein2
RNA Polymerase II Associated Protein 41 2     MBDin3
MBD2-Interacting Protein2 3     XPA-Binding Protein 13
XPA Binding Protein 11     

External Ids:    HGNC: 170301   Entrez Gene: 113212   Ensembl: ENSG000001985227   OMIM: 6114795   UniProtKB: Q9HCN43   

Export aliases for GPN1 gene to outside databases

Previous GC identifers: GC02P027705 GC02P027594


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GPN1 Gene:
This gene encodes a guanosine triphosphatase enzyme. The encoded protein may play a role in DNA repair and may
function in activation of transcription. Alternatively spliced transcript variants have been described. (provided
by RefSeq, Feb 2009)

GeneCards Summary for GPN1 Gene:
GPN1 (GPN-loop GTPase 1) is a protein-coding gene. GO annotations related to this gene include nucleoside-triphosphatase activity and GTP binding.

UniProtKB/Swiss-Prot: GPN1_HUMAN, Q9HCN4
Function: Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting
that it is required to connect RNA polymerase II to regulators of protein complex formation. May be involved in
nuclear localization of XPA




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the GPN1 gene promoter:
         HOXA9B   AhR   HOXA9   Meis-1a   Meis-1   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPN1 promoter sequence
   Search Chromatin IP Primers for GPN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GPN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.3   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23.3

GPN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPN1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P027821:  view genomic region     (about GC identifiers)

Start:
27,851,114 bp from pter      End:
27,874,375 bp from pter
Size:
23,262 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GPN1_HUMAN, Q9HCN4 (See protein sequence)
Recommended Name: GPN-loop GTPase 1  
Size: 374 amino acids; 41740 Da
Subunit: Tightly associated with the RNA polymerase II complex. Interacts with XPA
Secondary accessions: B4DQJ5 B4DXU4 B5MBZ5 O76004
Alternative splicing: 4 isoforms:  Q9HCN4-1   Q9HCN4-2   Q9HCN4-3   Q9HCN4-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GPN1: NX_Q9HCN4

Explore proteomics data for GPN1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys278, Lys297
  • Modification sites at PhosphoSitePlus

  • See GPN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001138519.1  NP_001138520.1  NP_001138521.1  NP_009197.2  

    ENSEMBL proteins: 
     ENSP00000424678   ENSP00000427269   ENSP00000384255   ENSP00000264718   ENSP00000395981  
     ENSP00000476446   ENSP00000412170   ENSP00000398115  

    GPN1 Human Recombinant Protein Products:

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    Novus Biologicals GPN1 Proteins
    Novus Biologicals GPN1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for GPN1
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for GPN1 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GPN: GPN-loop GTPases

    3 InterPro protein domains:
     IPR004130 Uncharacterised_ATP-bd
     IPR027417 P-loop_NTPase
     IPR003593 AAA+_ATPase

    Graphical View of Domain Structure for InterPro Entry Q9HCN4

    ProtoNet protein and cluster: Q9HCN4

    2 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB004130 Conserved hypothetical ATP binding protein


    UniProtKB/Swiss-Prot: GPN1_HUMAN, Q9HCN4
    Similarity: Belongs to the GPN-loop GTPase family


    Find genes that share domains with GPN1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GPN1_HUMAN, Q9HCN4
    Function: Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting
    that it is required to connect RNA polymerase II to regulators of protein complex formation. May be involved in
    nuclear localization of XPA

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003924GTPase activity ----
    GO:0005525GTP binding IEA--
    GO:0017111nucleoside-triphosphatase activity IEA--
         
    Find genes that share ontologies with GPN1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GPN1:
     Increased HPV18 LCR reporter a 

         1 MGI phenotypic allele for Gpn1 (no phenotypes)

    Find genes that share phenotypes with GPN1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GPN1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GPN1
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    miRNA
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    miRTarBase miRNAs that target GPN1:
    hsa-let-7a-5p (MIRT052371), hsa-mir-320a (MIRT044449), hsa-mir-98-5p (MIRT027807), hsa-mir-151a-5p (MIRT019517)

    Block miRNA regulation of human, mouse, rat GPN1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GPN1 (see all 13):
    hsa-miR-4291 hsa-miR-548p hsa-miR-922 hsa-miR-15a hsa-miR-452* hsa-miR-497 hsa-miR-545 hsa-miR-214
    SwitchGear 3'UTR luciferase reporter plasmidGPN1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat GPN1

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    GenScript: all cDNA clones in your preferred vector (see all 4): GPN1 (NM_007266)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPN1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPN1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GPN1_HUMAN, Q9HCN4: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion3
    cytosol1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0043231intracellular membrane-bounded organelle ----

    Find genes that share ontologies with GPN1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GPN1
    Interactions:

        Search GeneGlobe Interaction Network for GPN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GPN1 (Q9HCN42, 3 ENSP000002647184) via UniProtKB, MINT, STRING, and/or I2D (see all 160)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZBED1O960062, 3, ENSP000003706164MINT-66624 I2D: score=5 STRING: ENSP00000370616
    HSPA9P386463, ENSP000002971854I2D: score=3 STRING: ENSP00000297185
    MBD2Q9UBB53, ENSP000002564294I2D: score=3 STRING: ENSP00000256429
    HSPD1P108093, ENSP000003400194I2D: score=2 STRING: ENSP00000340019
    PSMC2P359983, ENSP000002926444I2D: score=2 STRING: ENSP00000292644
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GPN1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GPN1 gene (4 alternative transcripts): 
    NM_001145047.1  NM_001145048.1  NM_001145049.1  NM_007266.3  

    Unigene Cluster for GPN1:

    GPN-loop GTPase 1
    Hs.18259  [show with all ESTs]
    Unigene Representative Sequence: NM_007266
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000481754 ENST00000515877 ENST00000503738 ENST00000407583 ENST00000264718(uc010ymc.2 uc010ymd.2)
    ENST00000436280 ENST00000478484 ENST00000610189 ENST00000461249(uc010ezg.1)
    ENST00000458167(uc010ymb.2) ENST00000424214(uc010ezf.3 uc010yma.2)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate GPN1 (see all 13):
    hsa-miR-4291 hsa-miR-548p hsa-miR-922 hsa-miR-15a hsa-miR-452* hsa-miR-497 hsa-miR-545 hsa-miR-214
    SwitchGear 3'UTR luciferase reporter plasmidGPN1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for GPN1
    Predesigned siRNA for gene silencing in human, mouse, rat GPN1
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): GPN1 (NM_007266)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GPN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPN1
    Primer
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    OriGene qPCR primer pairs and template standards for GPN1
    OriGene qSTAR qPCR primer pairs in human, mouse for GPN1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GPN1
      QuantiTect SYBR Green Assays in human, mouse, rat GPN1
      QuantiFast Probe-based Assays in human, mouse, rat GPN1

    Additional mRNA sequence: 

    AB044661.1 AJ010842.1 AK298827.1 AK298866.1 AK302131.1 AK310340.1 AK311423.1 AK312992.1 
    AK316404.1 BC007451.2 NR_026735.1 

    13 DOTS entries:

    DT.100802471  DT.100675496  DT.100802465  DT.448385  DT.95114895  DT.121010760  DT.95135337  DT.100672702 
    DT.100802468  DT.100802475  DT.121010664  DT.121609760  DT.121617475 

    Selected AceView cDNA sequences (see all 238):

    BQ221397 W03588 AI140167 BC007451 BM461473 BM810685 AA291317 AI479453 
    BM762920 AA884754 CR602623 BG419532 CA417285 BI752213 AI382707 AU279449 
    AA385017 BM769237 BX441317 BU166078 AA453810 AA453895 BM848269 BG677338 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GPN1 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a ·
    SP1:                                            -     -     -                                                                                   -               
    SP2:                                            -     -     -     -                                                                             -               
    SP3:                                            -     -     -     -                                                                             -               
    SP4:                                      -     -     -     -     -                                                                                             
    SP5:                                            -     -     -                                                                                                   

    ExUns: 14b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for GPN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GPN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTAATGAAT
    GPN1 Expression
    About this image


    GPN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             Primary Oocyte Primary Follicle
     
     Gonad
             Primary Oocyte Primary Follicle
    GPN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GPN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.18259

    UniProtKB/Swiss-Prot: GPN1_HUMAN, Q9HCN4
    Tissue specificity: Expressed ubiquitously

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    QuantiFast Probe-based Assays in human, mouse, rat GPN1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GPN1 gene from Selected species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpn11 , 5 GPN-loop GTPase 11, 5 87.33(n)1
    92.01(a)1
      5 (17.27 cM)5
    742541  NM_133756.41  NP_598517.11 
     314947415 
    chicken
    (Gallus gallus)
    Aves XAB11 XPA binding protein 1, GTPase 74.93(n)
    80.99(a)
      421980  XM_419990.2  XP_419990.1 
    lizard
    (Anolis carolinensis)
    Reptilia GPN16
    GPN-loop GTPase 1
    75(a)
    1 ↔ 1
    GL343953.1(66189-95496)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.310842 Xenopus laevis transcribed sequence with moderate similarity more 74.5(n)    BU907016.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.148232 Transcribed sequence with strong similarity to protein more 79.27(n)    AL727954.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG37041 CG3704 60.35(n)
    61.69(a)
      31043  NM_130516.4  NP_569872.1 
    worm
    (Caenorhabditis elegans)
    Secernentea gop-21 gop-2 57.96(n)
    57.73(a)
      175722  NM_065717.5  NP_498118.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NPA3(YJR072C)4
    NPA31
    Essential, conserved, cytoplasmic ATPase; phosphorylated more4
    NPA31
    55.4(n)1
    56.31(a)1
      10(572124-570967)4
    8535351, 4  NP_012606.31  NP_012606.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons QQT21 QQT2 56.53(n)
    57.77(a)
      828268  NM_118300.3  NP_193911.1 
    rice
    (Oryza sativa)
    Liliopsida Os.147742 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.83(n)    AK073391.1 


    ENSEMBL Gene Tree for GPN1 (if available)
    TreeFam Gene Tree for GPN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GPN1 gene
    2 SIMAP similar genes for GPN1 using alignment to 3 protein entries:     GPN1_HUMAN (see all proteins):
    MBDin    GPN3

    Find genes that share paralogs with GPN1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for GPN1
    PGOHUM00000242543


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GPN1 (see all 424)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1835514371,2
    C--27853899(+) ATATTC/GGTGAT 7 R G int1 mis1 ut510--------
    rs798988421,2
    C,F--27853976(+) TGGCTT/GCTTGT 5 -- int11Minor allele frequency- G:0.07WA 118
    rs1822461501,2
    C--27854000(+) GGCTTG/TAAAGA 5 -- int10--------
    rs1882476091,2
    C--27854005(+) GAAAGA/GGTGTT 5 -- int10--------
    rs1927851041,2
    --27854261(+) AGAAAC/TGAGTG 5 -- int10--------
    rs1832866761,2
    --27854331(+) CAAGTC/TTAAGT 5 -- int10--------
    rs65477401,2
    C,F,A,H--27854369(+) GCTTGA/GTTTAT 5 -- int136Minor allele frequency- G:0.36NA NS EA WA CSA 3282
    rs769066311,2
    C,F--27854423(+) GACCAA/GTGCCA 5 -- int11Minor allele frequency- G:0.03WA 118
    rs345020531,2
    C,F--27854524(+) AGCCAG/AACCTT 5 -- int16Minor allele frequency- A:0.33NA CSA EA 248
    rs750846161,2
    C,F--27854532(+) CTTGAT/AAATGA 5 -- int11Minor allele frequency- A:0.05WA 118

    HapMap Linkage Disequilibrium report for GPN1 (27851114 - 27874375 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for GPN1: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing GPN1
    DNA2.0 Custom Variant and Variant Library Synthesis for GPN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611479    OMIM disorders: --


    Find genes that share disorders with GPN1           About GenesLikeMe

    Genetic Association Database (GAD): GPN1

    Export disorders for GPN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GPN1 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with GPN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of 16 novel human genes showing high similarity to yeast sequences. (PubMed id 11124703)1, 2, 3 Stanchi F.... Valle G. (Yeast 2001)
    2. A novel cytoplasmic GTPase XAB1 interacts with DNA repair protein XPA. (PubMed id 11058119)1, 2, 3 Nitta M....Tanaka K. (Nucleic Acids Res. 2000)
    3. A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. (PubMed id 21386085)1, 4 Kraja A.T....Borecki I.B. (Diabetes 2011)
    4. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PubMed id 17643375)1, 2 Jeronimo C.... Coulombe B. (Mol. Cell 2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. MBDin, a novel MBD2-interacting protein, relieves MBD2 repression potential and reactivates transcription from methylated promoters. (PubMed id 12588985)1, 9 Lembo F....Chiariotti L. (Mol. Cell. Biol. 2003)
    7. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. (PubMed id 23362303)1 Wu J.H....Mozaffarian D. (Circ Cardiovasc Genet 2013)
    8. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    9. Genome-wide association study of chronic periodontitis in a general German population. (PubMed id 24024966)1 Teumer A....Kocher T. (J. Clin. Periodontol. 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11321 HGNC: 17030 AceView: XAB1 Ensembl:ENSG00000198522 euGenes: HUgn11321
    ECgene: GPN1 H-InvDB: GPN1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GPN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GPN1 gene:
    Search GeneIP for patents involving GPN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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