Aliases for GPN1 Gene
External Ids for GPN1 Gene
Previous HGNC Symbols for GPN1 Gene
Previous GeneCards Identifiers for GPN1 Gene
This gene encodes a guanosine triphosphatase enzyme. The encoded protein may play a role in DNA repair and may function in activation of transcription. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]
GeneCards Summary for GPN1 Gene
GPN1 (GPN-Loop GTPase 1) is a Protein Coding gene. GO annotations related to this gene include GTP binding and nucleoside-triphosphatase activity.
UniProtKB/Swiss-Prot for GPN1 Gene
Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII) (PubMed:20855544, PubMed:21768307). May act at an RNAP assembly step prior to nuclear import (PubMed:21768307). Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation (PubMed:17643375). May be involved in nuclear localization of XPA (PubMed:11058119).