Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GPN1 Gene

Aliases for GPN1 Gene

  • GPN-Loop GTPase 1 2 3 5
  • RNA Polymerase II Associated Protein 4 2 3
  • XPA Binding Protein 1, GTPase 2 3
  • RNAPII-Associated Protein 4 3 4
  • MBD2-Interacting Protein 3 4
  • MBDIN 3 4
  • RPAP4 3 4
  • XAB1 3 4
  • ATP(GTP)-Binding Protein 3
  • XPA Binding Protein 1 2
  • XPA-Binding Protein 1 4
  • EC 3.6.5.- 4
  • ATPBD1A 3
  • NTPBP 3

External Ids for GPN1 Gene

Previous HGNC Symbols for GPN1 Gene

  • XAB1

Previous GeneCards Identifiers for GPN1 Gene

  • GC02P027705
  • GC02P027821

Summaries for GPN1 Gene

Entrez Gene Summary for GPN1 Gene

  • This gene encodes a guanosine triphosphatase enzyme. The encoded protein may play a role in DNA repair and may function in activation of transcription. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

GeneCards Summary for GPN1 Gene

GPN1 (GPN-Loop GTPase 1) is a Protein Coding gene. GO annotations related to this gene include nucleotide binding and GTPase activity.

UniProtKB/Swiss-Prot for GPN1 Gene

  • Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII) (PubMed:20855544, PubMed:21768307). May act at an RNAP assembly step prior to nuclear import (PubMed:21768307). Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation (PubMed:17643375). May be involved in nuclear localization of XPA (PubMed:11058119).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPN1 Gene

Genomics for GPN1 Gene

Regulatory Elements for GPN1 Gene

Enhancers for GPN1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPN1 on UCSC Golden Path with GeneCards custom track

Promoters for GPN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPN1 Gene

Chromosome:
2
Start:
27,628,247 bp from pter
End:
27,651,508 bp from pter
Size:
23,262 bases
Orientation:
Plus strand

Genomic View for GPN1 Gene

Genes around GPN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPN1 Gene

Proteins for GPN1 Gene

  • Protein details for GPN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCN4-GPN1_HUMAN
    Recommended name:
    GPN-loop GTPase 1
    Protein Accession:
    Q9HCN4
    Secondary Accessions:
    • B4DQJ5
    • B4DQM4
    • B4DXU4
    • B5MBZ5
    • O76004

    Protein attributes for GPN1 Gene

    Size:
    374 amino acids
    Molecular mass:
    41740 Da
    Quaternary structure:
    • Heterodimer with GPN3 (PubMed:21768307). Binds to RNA polymerase II (RNAPII) (PubMed:17643375, PubMed:20864038, PubMed:21844196). Interacts directly with RNAPII subunits RPB4 and RPB7 and the CTD of RPB1 (PubMed:21768307). Interacts with XPA (PubMed:11058119).

    Alternative splice isoforms for GPN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPN1 Gene

Proteomics data for GPN1 Gene at MOPED

Post-translational modifications for GPN1 Gene

  • Ubiquitination at Lys 278 and Lys 297
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPN1 Gene

Domains & Families for GPN1 Gene

Gene Families for GPN1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HCN4

UniProtKB/Swiss-Prot:

GPN1_HUMAN :
  • Belongs to the GPN-loop GTPase family.
Family:
  • Belongs to the GPN-loop GTPase family.
genes like me logo Genes that share domains with GPN1: view

Function for GPN1 Gene

Molecular function for GPN1 Gene

UniProtKB/Swiss-Prot Function:
Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII) (PubMed:20855544, PubMed:21768307). May act at an RNAP assembly step prior to nuclear import (PubMed:21768307). Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation (PubMed:17643375). May be involved in nuclear localization of XPA (PubMed:11058119).

Enzyme Numbers (IUBMB) for GPN1 Gene

Gene Ontology (GO) - Molecular Function for GPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25241168
genes like me logo Genes that share ontologies with GPN1: view
genes like me logo Genes that share phenotypes with GPN1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPN1

miRNA for GPN1 Gene

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPN1 Gene

Localization for GPN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPN1 Gene

Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000269 PubMed:20855544}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPN1 Gene COMPARTMENTS Subcellular localization image for GPN1 gene
Compartment Confidence
nucleus 5
mitochondrion 4

Gene Ontology (GO) - Cellular Components for GPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with GPN1: view

Pathways & Interactions for GPN1 Gene

SuperPathways for GPN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPN1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GPN1 Gene

Drugs & Compounds for GPN1 Gene

No Compound Related Data Available

Transcripts for GPN1 Gene

Unigene Clusters for GPN1 Gene

GPN-loop GTPase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPN1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a ·
SP1: - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - -
SP6: - - - -
SP7: - -
SP8: - -
SP9: - - - - -
SP10:
SP11:

ExUns: 14b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for GPN1 Gene

GeneLoc Exon Structure for
GPN1
ECgene alternative splicing isoforms for
GPN1

Expression for GPN1 Gene

mRNA expression in normal human tissues for GPN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GPN1 Gene

This gene is overexpressed in Bone (28.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GPN1 Gene



SOURCE GeneReport for Unigene cluster for GPN1 Gene Hs.18259

mRNA Expression by UniProt/SwissProt for GPN1 Gene

Q9HCN4-GPN1_HUMAN
Tissue specificity: Expressed ubiquitously.
genes like me logo Genes that share expression patterns with GPN1: view

Protein tissue co-expression partners for GPN1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for GPN1 Gene

Orthologs for GPN1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPN1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPN1 35
  • 92.03 (n)
  • 93.82 (a)
GPN1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPN1 35
  • 91.62 (n)
  • 95.86 (a)
GPN1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpn1 35
  • 87.33 (n)
  • 92.01 (a)
Gpn1 16
Gpn1 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPN1 35
  • 99.4 (n)
  • 98.97 (a)
GPN1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpn1 35
  • 87 (n)
  • 91.76 (a)
oppossum
(Monodelphis domestica)
Mammalia GPN1 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPN1 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves XAB1 35
  • 74.93 (n)
  • 80.99 (a)
GPN1 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPN1 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11612 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.31084 35
zebrafish
(Danio rerio)
Actinopterygii Dr.14823 35
zgc:100927 35
  • 72.74 (n)
  • 81.79 (a)
GPN1 36
  • 72 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1169 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010314 35
  • 63.73 (n)
  • 67.88 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3704 35
  • 60.35 (n)
  • 61.69 (a)
CG3704 36
  • 46 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea gop-2 35
  • 57.96 (n)
  • 57.73 (a)
gop-2 36
  • 50 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR428C 35
  • 57.71 (n)
  • 62.01 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B14124g 35
  • 58.18 (n)
  • 60.93 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NPA3 35
  • 55.4 (n)
  • 56.31 (a)
NPA3 36
  • 46 (a)
OneToOne
NPA3 38
thale cress
(Arabidopsis thaliana)
eudicotyledons QQT2 35
  • 56.53 (n)
  • 57.77 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.8234 35
barley
(Hordeum vulgare)
Liliopsida Hv.4333 35
rice
(Oryza sativa)
Liliopsida Os.14774 35
Os03g0312600 35
  • 59.52 (n)
  • 61.07 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.5068 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9261 35
bread mold
(Neurospora crassa)
Ascomycetes NCU04507 35
  • 57.16 (n)
  • 57.72 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC119.15 35
  • 55.48 (n)
  • 56.18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6086 36
  • 62 (a)
OneToOne
Species with no ortholog for GPN1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for GPN1 Gene

ENSEMBL:
Gene Tree for GPN1 (if available)
TreeFam:
Gene Tree for GPN1 (if available)

Paralogs for GPN1 Gene

(2) SIMAP similar genes for GPN1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for GPN1 Gene

genes like me logo Genes that share paralogs with GPN1: view

No data available for Paralogs for GPN1 Gene

Variants for GPN1 Gene

Sequence variations from dbSNP and Humsavar for GPN1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2141371 -- 27,637,391(-) ttact(C/T)atatg intron-variant
rs2178197 -- 27,637,684(-) ctgta(C/T)agtct intron-variant
rs11692692 -- 27,638,840(+) TTTGC(A/G)TTTGT intron-variant
rs6547740 -- 27,631,502(+) GCTTG(A/G)TTTAT intron-variant
rs6547741 -- 27,633,057(+) TGTCA(A/G)AATAG intron-variant

Variation tolerance for GPN1 Gene

Residual Variation Intolerance Score: 51.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.58; 78.04% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for GPN1 Gene

Disorders for GPN1 Gene

Relevant External Links for GPN1

Genetic Association Database (GAD)
GPN1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPN1

No disorders were found for GPN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPN1 Gene

Publications for GPN1 Gene

  1. Characterization of 16 novel human genes showing high similarity to yeast sequences. (PMID: 11124703) Stanchi F. … Valle G. (Yeast 2001) 2 3 4 67
  2. MBDin, a novel MBD2-interacting protein, relieves MBD2 repression potential and reactivates transcription from methylated promoters. (PMID: 12588985) Lembo F. … Chiariotti L. (Mol. Cell. Biol. 2003) 3 23
  3. A novel cytoplasmic GTPase XAB1 interacts with DNA repair protein XPA. (PMID: 11058119) Nitta M. … Tanaka K. (Nucleic Acids Res. 2000) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for GPN1 Gene

Sources for GPN1 Gene

Content