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Aliases for GPM6A Gene

Aliases for GPM6A Gene

  • Glycoprotein M6A 2 3 5
  • M6A 3 4
  • Neuronal Membrane Glycoprotein M6-A 3
  • GPM6 3

External Ids for GPM6A Gene

Previous HGNC Symbols for GPM6A Gene

  • GPM6

Previous GeneCards Identifiers for GPM6A Gene

  • GC04M177441
  • GC04M177104
  • GC04M177250
  • GC04M176929
  • GC04M176791
  • GC04M176554
  • GC04M172304

Summaries for GPM6A Gene

GeneCards Summary for GPM6A Gene

GPM6A (Glycoprotein M6A) is a Protein Coding gene. GO annotations related to this gene include calcium channel activity. An important paralog of this gene is GPM6B.

UniProtKB/Swiss-Prot for GPM6A Gene

  • Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor.

Gene Wiki entry for GPM6A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPM6A Gene

Genomics for GPM6A Gene

Regulatory Elements for GPM6A Gene

Enhancers for GPM6A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F176000 1 FANTOM5 ENCODE 33.7 +1.3 1295 0.9 ZNF133 INSM2 ZNF76 FEZF1 ZNF2 ZNF366 ZNF263 ZFP69B ZNF341 ZNF524 GPM6A WDR17 ENSG00000248249
GH04F175946 0.5 Ensembl 11 +55.9 55891 0.8 CTCF SMC3 RAD21 GPM6A WDR17 GC04M175911 ENSG00000248249
GH04F175935 0.2 ENCODE 10.7 +67.5 67467 0.2 ZNF217 CTBP1 JUND POLR2A DPF2 FOS TCF7L2 TEAD3 GPM6A GC04M175911 GC04P175867 GC04P175868
GH04F176090 0.4 FANTOM5 10.6 -87.7 -87651 0.3 GPM6A GC04P176099 WDR17
GH04F176156 0.2 ENCODE 10 -154.0 -154002 1.0 JUND GPM6A GC04M176150 SPATA4
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GPM6A on UCSC Golden Path with GeneCards custom track

Promoters for GPM6A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001865721 691 1600 ZNF133 INSM2 ZNF76 FEZF1 ZNF2 GLIS2 ZNF366 ZNF263 ZFP69B SMARCA4

Genomic Location for GPM6A Gene

Chromosome:
4
Start:
175,632,934 bp from pter
End:
176,002,691 bp from pter
Size:
369,758 bases
Orientation:
Minus strand

Genomic View for GPM6A Gene

Genes around GPM6A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPM6A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPM6A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPM6A Gene

Proteins for GPM6A Gene

  • Protein details for GPM6A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51674-GPM6A_HUMAN
    Recommended name:
    Neuronal membrane glycoprotein M6-a
    Protein Accession:
    P51674
    Secondary Accessions:
    • B7Z642
    • E9PHI5
    • Q92602

    Protein attributes for GPM6A Gene

    Size:
    278 amino acids
    Molecular mass:
    31210 Da
    Quaternary structure:
    • Interacts with OPRM1.

    Alternative splice isoforms for GPM6A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPM6A Gene

Post-translational modifications for GPM6A Gene

  • Glycosylation at Asn 164 and Asn 208
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPM6A Gene

Domains & Families for GPM6A Gene

Protein Domains for GPM6A Gene

Graphical View of Domain Structure for InterPro Entry

P51674

UniProtKB/Swiss-Prot:

GPM6A_HUMAN :
  • Belongs to the myelin proteolipid protein family.
Family:
  • Belongs to the myelin proteolipid protein family.
genes like me logo Genes that share domains with GPM6A: view

No data available for Gene Families for GPM6A Gene

Function for GPM6A Gene

Molecular function for GPM6A Gene

GENATLAS Biochemistry:
neuronal membrane glycoprotein M6A,35kDa,with strong homology to PLP,murine Gpm6 homolog
UniProtKB/Swiss-Prot Function:
Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor.

Gene Ontology (GO) - Molecular Function for GPM6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005262 calcium channel activity IEA --
GO:0005515 protein binding IPI 24705354
genes like me logo Genes that share ontologies with GPM6A: view
genes like me logo Genes that share phenotypes with GPM6A: view

Animal Models for GPM6A Gene

MGI Knock Outs for GPM6A:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPM6A

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPM6A Gene

Localization for GPM6A Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPM6A Gene

Cell membrane; Multi-pass membrane protein. Cell projection, axon. Cell projection, dendritic spine. Cell projection, filopodium. Note=Localizes to cholesterol-rich lipid rafts of the plasma membrane of hippocampal neurons. Localized to plasma membrane of cell bodies and neurites of hippocampal neurons. Localized in membrane protrusions (filopodia and spines) of primary hippocampal neurons. Localized to the growth cone edge membrane of elongating axons (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPM6A Gene COMPARTMENTS Subcellular localization image for GPM6A gene
Compartment Confidence
extracellular 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPM6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030175 filopodium ISS --
GO:0030424 axon IEA --
genes like me logo Genes that share ontologies with GPM6A: view

Pathways & Interactions for GPM6A Gene

SuperPathways for GPM6A Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPM6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IDA 19298174
GO:0003407 neural retina development ISS --
GO:0007399 nervous system development IEA --
GO:0007416 synapse assembly ISS --
GO:0048812 neuron projection morphogenesis ISS --
genes like me logo Genes that share ontologies with GPM6A: view

No data available for Pathways by source and SIGNOR curated interactions for GPM6A Gene

Transcripts for GPM6A Gene

Unigene Clusters for GPM6A Gene

Glycoprotein M6A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPM6A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
SP1: - - - -
SP2: - - - - - - - - - - -
SP3: -
SP4: - - - -
SP5: - - -
SP6: - - -
SP7: -
SP8:
SP9: - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - -

Relevant External Links for GPM6A Gene

GeneLoc Exon Structure for
GPM6A
ECgene alternative splicing isoforms for
GPM6A

Expression for GPM6A Gene

mRNA expression in normal human tissues for GPM6A Gene

mRNA differential expression in normal tissues according to GTEx for GPM6A Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.4), Brain - Anterior cingulate cortex (BA24) (x6.4), Brain - Amygdala (x6.1), Brain - Cerebellar Hemisphere (x5.2), and Brain - Hippocampus (x4.3).

Protein differential expression in normal tissues from HIPED for GPM6A Gene

This gene is overexpressed in Frontal cortex (36.8), Brain (15.4), and Fetal Brain (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPM6A Gene



Protein tissue co-expression partners for GPM6A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPM6A Gene:

GPM6A

SOURCE GeneReport for Unigene cluster for GPM6A Gene:

Hs.75819
genes like me logo Genes that share expression patterns with GPM6A: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for GPM6A Gene

Orthologs for GPM6A Gene

This gene was present in the common ancestor of animals.

Orthologs for GPM6A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPM6A 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia GPM6A 35
  • 100 (a)
OneToOne
LOC475641 34
  • 92.93 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GPM6A 35
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPM6A 35
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpm6a 34
  • 93.65 (n)
cow
(Bos Taurus)
Mammalia GPM6A 34 35
  • 92.81 (n)
mouse
(Mus musculus)
Mammalia Gpm6a 34 16 35
  • 91.97 (n)
chicken
(Gallus gallus)
Aves GPM6A 34 35
  • 85.73 (n)
lizard
(Anolis carolinensis)
Reptilia GPM6A 35
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpm6a 34
  • 82.73 (n)
African clawed frog
(Xenopus laevis)
Amphibia gpm6a-A 34
zebrafish
(Danio rerio)
Actinopterygii gpm6ab 35
  • 79 (a)
OneToMany
gpm6aa 34 35
  • 76.62 (n)
Dr.28363 34
fruit fly
(Drosophila melanogaster)
Insecta M6 34 35
  • 46.33 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012018 34
  • 45.83 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
OneToMany
Species where no ortholog for GPM6A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPM6A Gene

ENSEMBL:
Gene Tree for GPM6A (if available)
TreeFam:
Gene Tree for GPM6A (if available)

Paralogs for GPM6A Gene

Paralogs for GPM6A Gene

genes like me logo Genes that share paralogs with GPM6A: view

Variants for GPM6A Gene

Sequence variations from dbSNP and Humsavar for GPM6A Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10000752 -- 175,847,970(+) ATAAG(C/G)GGAAA intron-variant
rs10000906 -- 175,845,899(+) CCTCC(A/G)AGCTG intron-variant
rs10001442 -- 175,950,985(+) TTTTT(C/T)TCTCC intron-variant
rs10001667 -- 175,754,441(+) TATCC(C/T)AAACT intron-variant
rs10001784 -- 175,921,276(+) TTATC(C/T)AATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPM6A Gene

Variant ID Type Subtype PubMed ID
dgv1549e212 CNV loss 25503493
dgv2950n106 CNV deletion 24896259
esv1009508 CNV deletion 20482838
esv2660682 CNV deletion 23128226
esv2663422 CNV deletion 23128226
esv2667474 CNV deletion 23128226
esv2728772 CNV deletion 23290073
esv3406538 CNV insertion 20981092
esv34137 CNV loss 18971310
esv3565051 CNV deletion 23714750
esv3569837 CNV loss 25503493
esv3603264 CNV loss 21293372
esv3603265 CNV loss 21293372
esv3603266 CNV loss 21293372
esv3603268 CNV gain 21293372
esv3603269 CNV gain 21293372
esv3603271 CNV gain 21293372
esv3603272 CNV loss 21293372
nsv1110780 CNV insertion 24896259
nsv290701 CNV insertion 16902084
nsv470094 CNV loss 18288195
nsv822847 CNV gain 20364138
nsv822848 CNV loss 20364138
nsv830157 CNV gain 17160897

Variation tolerance for GPM6A Gene

Residual Variation Intolerance Score: 22.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.20; 4.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPM6A Gene

Human Gene Mutation Database (HGMD)
GPM6A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPM6A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPM6A Gene

Disorders for GPM6A Gene

Relevant External Links for GPM6A

Genetic Association Database (GAD)
GPM6A
Human Genome Epidemiology (HuGE) Navigator
GPM6A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPM6A

No disorders were found for GPM6A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPM6A Gene

Publications for GPM6A Gene

  1. Chromosomal mapping of the human M6 genes. (PMID: 8661015) Olinsky S. … Narayanan V. (Genomics 1996) 2 3 4 22 64
  2. Human GPM6A is associated with differentiation and neuronal migration of neurons derived from human embryonic stem cells. (PMID: 19298174) Michibata H. … Taniguchi T. (Stem Cells Dev. 2009) 3 4 22 64
  3. Membrane glycoprotein M6A promotes mu-opioid receptor endocytosis and facilitates receptor sorting into the recycling pathway. (PMID: 18574501) Liang Y.J. … Koch T. (Cell Res. 2008) 2 3 22 64
  4. Do mood symptoms subdivide the schizophrenia phenotype? Association of the GMP6A gene with a depression subgroup. (PMID: 18163405) Boks M.P. … Kahn R.S. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 22 46 64
  5. Isolation and mapping of the human glycoprotein M6 gene (GPM6A) to 4q33-->q34. (PMID: 8893821) Shimizu F. … Maekawa H. (Cytogenet. Cell Genet. 1996) 3 4 22 64

Products for GPM6A Gene

Sources for GPM6A Gene

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