Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GPM6A Gene

Aliases for GPM6A Gene

  • Glycoprotein M6A 2 3
  • M6A 3 4
  • GPM6 3

External Ids for GPM6A Gene

Previous HGNC Symbols for GPM6A Gene

  • GPM6

Previous GeneCards Identifiers for GPM6A Gene

  • GC04M177441
  • GC04M177104
  • GC04M177250
  • GC04M176929
  • GC04M176791
  • GC04M176554
  • GC04M172304

Summaries for GPM6A Gene

GeneCards Summary for GPM6A Gene

GPM6A (Glycoprotein M6A) is a Protein Coding gene. GO annotations related to this gene include calcium channel activity. An important paralog of this gene is GPM6B.

UniProtKB/Swiss-Prot for GPM6A Gene

  • Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor.

Gene Wiki entry for GPM6A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPM6A Gene

Genomics for GPM6A Gene

Regulatory Elements for GPM6A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GPM6A Gene

Chromosome:
4
Start:
175,632,934 bp from pter
End:
176,002,691 bp from pter
Size:
369,758 bases
Orientation:
Minus strand

Genomic View for GPM6A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPM6A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPM6A Gene

Proteins for GPM6A Gene

  • Protein details for GPM6A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51674-GPM6A_HUMAN
    Recommended name:
    Neuronal membrane glycoprotein M6-a
    Protein Accession:
    P51674
    Secondary Accessions:
    • B7Z642
    • E9PHI5
    • Q92602

    Protein attributes for GPM6A Gene

    Size:
    278 amino acids
    Molecular mass:
    31210 Da
    Quaternary structure:
    • Interacts with OPRM1.

    Alternative splice isoforms for GPM6A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPM6A Gene

Proteomics data for GPM6A Gene at MOPED

Post-translational modifications for GPM6A Gene

  • Glycosylation at Asn 164 and Asn 208
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for GPM6A

No data available for DME Specific Peptides for GPM6A Gene

Domains & Families for GPM6A Gene

Protein Domains for GPM6A Gene

Graphical View of Domain Structure for InterPro Entry

P51674

UniProtKB/Swiss-Prot:

GPM6A_HUMAN :
  • Belongs to the myelin proteolipid protein family.
Family:
  • Belongs to the myelin proteolipid protein family.
genes like me logo Genes that share domains with GPM6A: view

No data available for Gene Families for GPM6A Gene

Function for GPM6A Gene

Molecular function for GPM6A Gene

GENATLAS Biochemistry:
neuronal membrane glycoprotein M6A,35kDa,with strong homology to PLP,murine Gpm6 homolog
UniProtKB/Swiss-Prot Function:
Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor.

Gene Ontology (GO) - Molecular Function for GPM6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005262 calcium channel activity IEA --
GO:0005515 protein binding IPI 24705354
genes like me logo Genes that share ontologies with GPM6A: view
genes like me logo Genes that share phenotypes with GPM6A: view

Animal Models for GPM6A Gene

MGI Knock Outs for GPM6A:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPM6A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for GPM6A Gene

Localization for GPM6A Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPM6A Gene

Cell membrane; Multi-pass membrane protein. Cell projection, axon. Cell projection, dendritic spine. Cell projection, filopodium. Note=Localizes to cholesterol-rich lipid rafts of the plasma membrane of hippocampal neurons. Localized to plasma membrane of cell bodies and neurites of hippocampal neurons. Localized in membrane protrusions (filopodia and spines) of primary hippocampal neurons. Localized to the growth cone edge membrane of elongating axons (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPM6A Gene COMPARTMENTS Subcellular localization image for GPM6A gene
Compartment Confidence
extracellular 5
plasma membrane 4

Gene Ontology (GO) - Cellular Components for GPM6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane ISS --
GO:0016021 integral component of membrane IEA --
GO:0030175 filopodium ISS --
GO:0043005 neuron projection ISS --
GO:0043025 neuronal cell body ISS --
genes like me logo Genes that share ontologies with GPM6A: view

Pathways & Interactions for GPM6A Gene

SuperPathways for GPM6A Gene

No Data Available

PCR Array Products

Gene Ontology (GO) - Biological Process for GPM6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IDA 19298174
GO:0003407 neural retina development ISS --
GO:0007416 synapse assembly ISS --
GO:0048812 neuron projection morphogenesis ISS --
GO:0048863 stem cell differentiation IDA 19298174
genes like me logo Genes that share ontologies with GPM6A: view

No data available for Pathways by source and SIGNOR curated interactions for GPM6A Gene

Drugs & Compounds for GPM6A Gene

No Compound Related Data Available

Transcripts for GPM6A Gene

Unigene Clusters for GPM6A Gene

Glycoprotein M6A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPM6A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPM6A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
SP1: - - - -
SP2: - - - - - - - - - - -
SP3: -
SP4: - - - -
SP5: - - -
SP6: - - -
SP7: -
SP8:
SP9: - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - -

Relevant External Links for GPM6A Gene

GeneLoc Exon Structure for
GPM6A
ECgene alternative splicing isoforms for
GPM6A

Expression for GPM6A Gene

mRNA expression in normal human tissues for GPM6A Gene

mRNA differential expression in normal tissues according to GTEx for GPM6A Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.4), Brain - Anterior cingulate cortex (BA24) (x6.4), Brain - Amygdala (x6.1), Brain - Cerebellar Hemisphere (x5.2), and Brain - Hippocampus (x4.3).

Protein differential expression in normal tissues from HIPED for GPM6A Gene

This gene is overexpressed in Frontal cortex (36.8), Brain (15.4), and Fetal Brain (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPM6A Gene



SOURCE GeneReport for Unigene cluster for GPM6A Gene Hs.75819

genes like me logo Genes that share expression patterns with GPM6A: view

Protein tissue co-expression partners for GPM6A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GPM6A Gene

Orthologs for GPM6A Gene

This gene was present in the common ancestor of animals.

Orthologs for GPM6A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPM6A 35
  • 92.81 (n)
  • 100 (a)
GPM6A 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC475641 35
  • 92.93 (n)
  • 99.64 (a)
GPM6A 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpm6a 35
  • 91.97 (n)
  • 98.92 (a)
Gpm6a 16
Gpm6a 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPM6A 35
  • 100 (n)
  • 100 (a)
GPM6A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpm6a 35
  • 93.65 (n)
  • 99.64 (a)
oppossum
(Monodelphis domestica)
Mammalia GPM6A 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPM6A 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPM6A 35
  • 85.73 (n)
  • 94.24 (a)
GPM6A 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPM6A 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpm6a 35
  • 82.73 (n)
  • 95.68 (a)
African clawed frog
(Xenopus laevis)
Amphibia gpm6a-A 35
zebrafish
(Danio rerio)
Actinopterygii Dr.28363 35
gpm6aa 35
  • 76.62 (n)
  • 85.25 (a)
gpm6aa 36
  • 85 (a)
OneToMany
gpm6ab 36
  • 79 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012018 35
  • 45.83 (n)
  • 31.05 (a)
fruit fly
(Drosophila melanogaster)
Insecta M6 35
  • 46.33 (n)
  • 31.1 (a)
M6 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToMany
Species with no ortholog for GPM6A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPM6A Gene

ENSEMBL:
Gene Tree for GPM6A (if available)
TreeFam:
Gene Tree for GPM6A (if available)

Paralogs for GPM6A Gene

Paralogs for GPM6A Gene

genes like me logo Genes that share paralogs with GPM6A: view

Variants for GPM6A Gene

Sequence variations from dbSNP and Humsavar for GPM6A Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_014895 -

Structural Variations from Database of Genomic Variants (DGV) for GPM6A Gene

Variant ID Type Subtype PubMed ID
nsv880864 CNV Loss 21882294
dgv5834n71 CNV Loss 21882294
nsv470094 CNV Loss 18288195
dgv5835n71 CNV Loss 21882294
esv2660682 CNV Deletion 23128226
nsv822847 CNV Gain 20364138
esv2667474 CNV Deletion 23128226
nsv822848 CNV Loss 20364138
esv2728772 CNV Deletion 23290073
nsv830157 CNV Gain 17160897
esv34137 CNV Loss 18971310
esv1009508 CNV Deletion 20482838
nsv290701 CNV Insertion 16902084
esv2663422 CNV Deletion 23128226

Variation tolerance for GPM6A Gene

Residual Variation Intolerance Score: 22.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.20; 4.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPM6A Gene

HapMap Linkage Disequilibrium report
GPM6A
Human Gene Mutation Database (HGMD)
GPM6A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPM6A Gene

Disorders for GPM6A Gene

Relevant External Links for GPM6A

Genetic Association Database (GAD)
GPM6A
Human Genome Epidemiology (HuGE) Navigator
GPM6A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPM6A
genes like me logo Genes that share disorders with GPM6A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPM6A Gene

Publications for GPM6A Gene

  1. Membrane glycoprotein M6A promotes mu-opioid receptor endocytosis and facilitates receptor sorting into the recycling pathway. (PMID: 18574501) Liang Y.J. … Koch T. (Cell Res. 2008) 2 23 67
  2. Chromosomal mapping of the human M6 genes. (PMID: 8661015) Olinsky S. … Narayanan V. (Genomics 1996) 2 23 67
  3. Human GPM6A is associated with differentiation and neuronal migration of neurons derived from human embryonic stem cells. (PMID: 19298174) Michibata H. … Taniguchi T. (Stem Cells Dev. 2009) 23 67
  4. Cysteine residues in the large extracellular loop (EC2) are essential for the function of the stress-regulated glycoprotein M6a. (PMID: 19737934) Fuchsova B. … Frasch A.C. (J. Biol. Chem. 2009) 23 67
  5. Do mood symptoms subdivide the schizophrenia phenotype? Association of the GMP6A gene with a depression subgroup. (PMID: 18163405) Boks M.P. … Kahn R.S. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 23 67

Products for GPM6A Gene

Sources for GPM6A Gene

Back to Top

Content