Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GPLD1 Gene

Aliases for GPLD1 Gene

  • Glycosylphosphatidylinositol Specific Phospholipase D1 2 3
  • Glycoprotein Phospholipase D 3 4
  • GPI-Specific Phospholipase D 3 4
  • EC 4 63
  • PI-G PLD 3 4
  • GPI-PLD 3 4
  • PIGPLD1 3 4
  • GPIPLD 3 6
  • PIGPLD 3 6
  • Glycosyl-Phosphatidylinositol-Specific Phospholipase D 4
  • Phosphatidylinositol-Glycan-Specific Phospholipase D 3
  • PLD 3

External Ids for GPLD1 Gene

Previous GeneCards Identifiers for GPLD1 Gene

  • GC06M024485
  • GC06M024536
  • GC06M024377

Summaries for GPLD1 Gene

Entrez Gene Summary for GPLD1 Gene

  • Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPLD1 Gene

GPLD1 (Glycosylphosphatidylinositol Specific Phospholipase D1) is a Protein Coding gene. Among its related pathways are Development FGFR signaling pathway and GPCR Pathway. GO annotations related to this gene include sodium channel regulator activity and glycosylphosphatidylinositol phospholipase D activity.

UniProtKB/Swiss-Prot for GPLD1 Gene

  • This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane

Gene Wiki entry for GPLD1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPLD1 Gene

Genomics for GPLD1 Gene

Regulatory Elements for GPLD1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GPLD1 Gene

24,424,565 bp from pter
24,495,205 bp from pter
70,641 bases
Minus strand

Genomic View for GPLD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPLD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPLD1 Gene

Proteins for GPLD1 Gene

  • Protein details for GPLD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phosphatidylinositol-glycan-specific phospholipase D
    Protein Accession:
    Secondary Accessions:
    • Q15127
    • Q15128
    • Q2M2F2
    • Q5T3Y0
    • Q7Z6T8
    • Q8TCV0
    • Q8WW82
    • Q96ID6
    • Q9H167
    • Q9H4M1
    • Q9UJC9

    Protein attributes for GPLD1 Gene

    840 amino acids
    Molecular mass:
    92336 Da
    Quaternary structure:
    • Monomer.
    • Sequence=AAA36444.1; Type=Miscellaneous discrepancy; Note=This sequence has numerous of conflicts with the human genome.; Evidence={ECO:0000305};

    Alternative splice isoforms for GPLD1 Gene


neXtProt entry for GPLD1 Gene

Proteomics data for GPLD1 Gene at MOPED

Selected DME Specific Peptides for GPLD1 Gene

Post-translational modifications for GPLD1 Gene

  • Glycosylation at Asn94, Asn271, Asn292, Asn307, Asn321, Asn501, Asn568, Asn591, Asn604, and Asn659
  • Modification sites at PhosphoSitePlus

Other Protein References for GPLD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains for GPLD1 Gene

Protein Domains for GPLD1 Gene

Suggested Antigen Peptide Sequences for GPLD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P80108
  • Belongs to the GPLD1 family.
  • Contains 7 FG-GAP repeats.
genes like me logo Genes that share domains with GPLD1: view

No data available for Gene Families for GPLD1 Gene

Function for GPLD1 Gene

Molecular function for GPLD1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(2)O = 6-(alpha-D-glucosaminyl)-1D-myo-inositol + phosphatidate
UniProtKB/Swiss-Prot Function: This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane

Enzyme Numbers (IUBMB) for GPLD1 Gene

Gene Ontology (GO) - Molecular Function for GPLD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004621 glycosylphosphatidylinositol phospholipase D activity TAS 2017684
GO:0004630 phospholipase D activity IDA 2760042
GO:0005515 protein binding --
GO:0017080 sodium channel regulator activity ISS --
genes like me logo Genes that share ontologies with GPLD1: view

Animal Model Products

CRISPR Products

miRNA for GPLD1 Gene

miRTarBase miRNAs that target GPLD1

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for GPLD1 Gene

Localization for GPLD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPLD1 Gene


Subcellular locations from

Jensen Localization Image for GPLD1 Gene COMPARTMENTS Subcellular localization image for GPLD1 gene
Compartment Confidence
extracellular 5
cytosol 2
plasma membrane 2
lysosome 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GPLD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix ISS --
GO:0005615 extracellular space IDA 15907827
GO:0005622 intracellular IDA 15907827
GO:0005737 cytoplasm ISS --
GO:0005765 lysosomal membrane IDA 17897319
genes like me logo Genes that share ontologies with GPLD1: view

Pathways for GPLD1 Gene

genes like me logo Genes that share pathways with GPLD1: view

Pathways by source for GPLD1 Gene

Gene Ontology (GO) - Biological Process for GPLD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification ISS --
GO:0002042 cell migration involved in sprouting angiogenesis IMP 17720976
GO:0002062 chondrocyte differentiation ISS --
GO:0002430 complement receptor mediated signaling pathway IDA 15907827
GO:0006507 GPI anchor release IMP 17720976
genes like me logo Genes that share ontologies with GPLD1: view

Compounds for GPLD1 Gene

(18) HMDB Compounds for GPLD1 Gene

Compound Synonyms Cas Number PubMed IDs
  • Lysophosphatidic acid(16:0)
Not Available
  • 2-octadecanoyl-phosphatidic acid
Not Available
  • LPA(18:1)
Not Available
  • LPA(0:0/18:2n6)
Not Available
  • Lysophosphatidic acid(16:0/0:0)
Not Available

(21) Novoseek inferred chemical compound relationships for GPLD1 Gene

Compound -log(P) Hits PubMed IDs
glyceryl monooleate 65.9 2
sodium nitrite 62.2 4
inositol 59 2
monoacylglycerol 54.2 1
1,10-phenanthroline 53.9 4
genes like me logo Genes that share compounds with GPLD1: view

Transcripts for GPLD1 Gene

Unigene Clusters for GPLD1 Gene

Glycosylphosphatidylinositol specific phospholipase D1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPLD1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for GPLD1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPLD1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - -
SP3: -

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26

Relevant External Links for GPLD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPLD1 Gene

mRNA expression in normal human tissues for GPLD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPLD1 Gene

This gene is overexpressed in Liver (8.5), Brain - Cerebellar Hemisphere (5.2), and Brain - Cerebellum (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GPLD1 Gene

SOURCE GeneReport for Unigene cluster for GPLD1 Gene Hs.533291

genes like me logo Genes that share expressions with GPLD1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GPLD1 Gene

Orthologs for GPLD1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GPLD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPLD1 35
  • 98.25 (n)
  • 97.49 (a)
GPLD1 36
  • 98 (a)
(Bos Taurus)
Mammalia GPLD1 35
  • 84.62 (n)
  • 81.88 (a)
GPLD1 36
  • 82 (a)
(Canis familiaris)
Mammalia GPLD1 35
  • 84.55 (n)
  • 83.79 (a)
GPLD1 36
  • 83 (a)
(Mus musculus)
Mammalia Gpld1 35
  • 80.4 (n)
  • 79.29 (a)
Gpld1 16
Gpld1 36
  • 79 (a)
(Monodelphis domestica)
Mammalia GPLD1 36
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia GPLD1 36
  • 63 (a)
(Rattus norvegicus)
Mammalia Gpld1 35
  • 81.31 (n)
  • 80.48 (a)
(Gallus gallus)
Aves GPLD1 35
  • 65.83 (n)
  • 62.16 (a)
GPLD1 36
  • 62 (a)
(Anolis carolinensis)
Reptilia GPLD1 36
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493339 35
  • 63.94 (n)
  • 59.96 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 18 (a)
-- 38
Species with no ortholog for GPLD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GPLD1 Gene

Gene Tree for GPLD1 (if available)
Gene Tree for GPLD1 (if available)

Paralogs for GPLD1 Gene

No data available for Paralogs for GPLD1 Gene

Variants for GPLD1 Gene

Sequence variations from dbSNP and Humsavar for GPLD1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs760903 -- 24,474,430(+) TAAAA(A/G)GAGAG intron-variant
rs760904 -- 24,476,325(+) TTGGA(A/G)AGTCT intron-variant
rs760905 -- 24,479,554(+) TCACA(C/T)GCTAA intron-variant
rs760906 -- 24,479,617(+) TCATG(C/T)CACTT intron-variant
rs760907 -- 24,479,645(+) TAGTT(C/T)TCAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPLD1 Gene

Variant ID Type Subtype PubMed ID
nsv820266 CNV Gain 19587683
esv2229610 CNV Deletion 18987734
esv2731712 CNV Deletion 23290073
nsv519552 CNV Gain 19592680
nsv515988 CNV Loss 19592680
nsv525943 CNV Loss 19592680
nsv883480 CNV Loss 21882294
esv34020 CNV Loss 18971310

Relevant External Links for GPLD1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPLD1 Gene

Disorders for GPLD1 Gene

(8) Novoseek inferred disease relationships for GPLD1 Gene

Disease -log(P) Hits PubMed IDs
myeloid leukemia 27 2
colon carcinoma 15.8 1
liver diseases 4.93 1
insulin resistance 2.86 4
leukemia 0 6

Relevant External Links for GPLD1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with GPLD1: view

No data available for UniProtKB/Swiss-Prot for GPLD1 Gene

Publications for GPLD1 Gene

  1. Structure and expression of the human glycosylphosphatidylinositol phospholipase D1 (GPLD1) gene. (PMID: 11072085) Schofield J.N. … Rademacher T.W. (Biochim. Biophys. Acta 2000) 2 3 4 23
  2. Phosphatidylinositol-glycan-specific phospholipase D is an amphiphilic glycoprotein that in serum is associated with high-density lipoproteins. (PMID: 1606959) Hoener M.C. … Brodbeck U. (Eur. J. Biochem. 1992) 3 4 23
  3. GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex. (PMID: 11254757) Deeg M.A. … Cheung M.C. (J. Lipid Res. 2001) 3 23
  4. Production of the glycosylphosphatidylinositol-specific phospholipase D by the islets of Langerhans. (PMID: 1833386) Metz C.N. … Davitz M.A. (J. Biol. Chem. 1991) 3 23
  5. Primary structure and functional activity of a phosphatidylinositol-glycan-specific phospholipase D. (PMID: 2017684) Scallon B.J. … Kochan J.P. (Science 1991) 3 23

Products for GPLD1 Gene

Sources for GPLD1 Gene

Back to Top