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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GPLD1 Gene

protein-coding   GIFtS: 56
GCID: GC06M024377

glycosylphosphatidylinositol specific phospholipase D1

 Explore 22 diseases affiliated with
GPLD1 via our new
 Human Malady Compendium 
Biological research products
for GPLD1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Glycosylphosphatidylinositol Specific Phospholipase D11 2     EC 3.1.4.503 8
Glycoprotein Phospholipase D2 3     GPIPLD2 5
GPI-PLD2 3     PIGPLD2 5
PIGPLD12 3     GPIPLDM2
GPI-Specific Phospholipase D2 3     Phosphatidylinositol-Glycan-Specific Phospholipase D2
PI-G PLD2 3     Glycosyl-Phosphatidylinositol-Specific Phospholipase D3

External Ids:    HGNC: 44591   Entrez Gene: 28222   Ensembl: ENSG000001122937   OMIM: 6025155   UniProtKB: P801083   

Export aliases for GPLD1 gene to outside databases

Previous GC identifers: GC06M024485 GC06M024536


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GPLD1:
Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol
(GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI
degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in
proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PHLD_HUMAN, P80108
Function: This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans
(GPI-anchor) thus releasing these proteins from the membrane

Gene Wiki entry for GPLD1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GPLD1 gene promoter:
         RFX1   p53   Meis-1a   Meis-1b   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPLD1 promoter sequence
   Search SABiosciences Chromatin IP Primers for GPLD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPLD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.3   HGNC cytogenetic band: 6p22.1

GPLD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPLD1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M024377:  view genomic region     (about GC identifiers)

Start:
24,424,793 bp from pter      End:
24,495,433 bp from pter
Size:
70,641 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PHLD_HUMAN, P80108 (See protein sequence)
Recommended Name: Phosphatidylinositol-glycan-specific phospholipase D precursor  
Size: 840 amino acids; 92336 Da
Subunit: Monomer (Potential)
Subcellular location: Secreted
Sequence caution: Sequence=AAA36444.1; Type=Miscellaneous discrepancy; Note=This sequence has numerous of conflicts
with the human genome;
Secondary accessions: Q15127 Q15128 Q2M2F2 Q5T3Y0 Q7Z6T8 Q8TCV0 Q8WW82 Q96ID6 Q9H167 Q9H4M1 Q9UJC9
Alternative splicing: 2 isoforms:  P80108-1   P80108-2   

Explore the universe of human proteins at neXtProt for GPLD1: NX_P80108

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P80108

  • 4 DME Specific Peptides for GPLD1 (P80108)
     DGLDEII  HQDAYQAG  CNLPENPLFI  AGDFGGDVLSQFEF 

    GPLD1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001494.2  
    ENSEMBL proteins: 
     ENSP00000230036   ENSP00000367489  

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    Uscn Proteins for GPLD1

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix ISS--
    GO:0005615extracellular space IDA15907827
    GO:0005622intracellular IDA15907827
    GO:0005737cytoplasm ISS--
    GO:0005792microsome ----


    GPLD1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for GPLD1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    GPLD1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR013519 Int_alpha_beta-p
     IPR013517 FG-GAP
     IPR001028 Gprt_PLipase_D

    Graphical View of Domain Structure for InterPro Entry P80108

    ProtoNet protein and cluster: P80108

    1 Blocks protein family: IPB001028 Phospholipase D signature

    UniProtKB/Swiss-Prot: PHLD_HUMAN, P80108
    Similarity: Belongs to the GPLD1 family
    Similarity: Contains 7 FG-GAP repeats


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: PHLD_HUMAN, P80108
    Function: This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans
    (GPI-anchor) thus releasing these proteins from the membrane
    Catalytic activity: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(2)O =
    6-(alpha-D-glucosaminyl)-1D-myo-inositol + phosphatidate

    Enzyme Number (IUBMB): EC 3.1.4.501 2

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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004621glycosylphosphatidylinositol phospholipase D activity TAS2017684
    GO:0004630phospholipase D activity IDA2760042
    GO:0017080sodium channel regulator activity ISS--


    GPLD1 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1G-AlphaQ Signaling
    G-AlphaQ Signaling1.00
    2Post-translational modification: synthesis of GPI-anchored proteins
    Glycosylphosphatidylinositol(GPI)-anchor biosynthesis0.79
    3GPCR Pathway
    Ras Pathway0.62
    4PAK Pathway
    Antioxidant Action of Vitamin-C0.56
    5PTEN Pathway
    Phospholipase-C Pathway0.56

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GPLD1 (see all 8)
        FGF Pathway
    Endothelin-1 Signaling Pathway
    Antioxidant Action of Vitamin-C
    Sperm Motility
    Phospholipase-C Pathway


    1         Kegg Pathway  (Kegg details for GPLD1):
        Glycosylphosphatidylinositol(GPI)-anchor biosynthesis


    GPLD1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GPLD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/8 Interacting proteins for GPLD1 (P801083 ENSP000002300364) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD55P081743, ENSP000003163334I2D: score=2 STRING: ENSP00000316333
    GM2AP179003, ENSP000003496874I2D: score=2 STRING: ENSP00000349687
    ALPPP051873, ENSP000003758814I2D: score=1 STRING: ENSP00000375881
    APOA1P026473, ENSP000002368504I2D: score=2 STRING: ENSP00000236850
    PIGLENSP000002256094STRING: ENSP00000225609
    About this table

    Gene Ontology (GO): 5/30 biological process terms (GO ID links to tree view) (see all 30):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification ISS--
    GO:0002042cell migration involved in sprouting angiogenesis IMP17720976
    GO:0002062chondrocyte differentiation ISS--
    GO:0002430complement receptor mediated signaling pathway IDA15907827
    GO:0006507GPI anchor release IMP17720976


    GPLD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GPLD1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GPLD1

    10/18 HMDB Compounds for GPLD1 (see all 18)    About this table
    CompoundSynonyms CAS #PubMed Ids
    LPA(0:0/16:0)Lysophosphatidic acid(16:0) (see all 6)----
    LPA(0:0/18:0)2-octadecanoyl-phosphatidic acid (see all 6)----
    LPA(0:0/18:1(9Z))LPA(18:1) (see all 10)----
    LPA(0:0/18:2(9Z,12Z))LPA(0:0/18:2n6) (see all 10)----
    LPA(16:0/0:0)Lysophosphatidic acid(16:0/0:0) (see all 14)----
    LPA(18:0/0:0)1-octadecanoyl-phosphatidic acid (see all 6)----
    LPA(18:1(9Z)/0:0)1-oleoyl-glycero-3-phosphate (see all 26)----
    LPA(18:2(9Z,12Z)/0:0)LPA(18:2w6/0:0) (see all 10)----
    PA(16:0/16:0)Dipalmitoylphosphatidic acid (see all 25)7091-44-3--
    PA(16:0/18:1(11Z))PA(16:0/18:1n7) (see all 10)----
    10/21 Novoseek chemical compound relationships for GPLD1 gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glyceryl monooleate 65.9 2 10591409 (2)
    sodium nitrite 62.2 4 1708886 (1), 1378620 (1), 8300589 (1), 9144552 (1)
    inositol 59 2 1313004 (1), 7651182 (1)
    monoacylglycerol 54.2 2 10591409 (1)
    1,10-phenanthroline 53.9 4 17467053 (1), 14611645 (1), 7512501 (1), 15893415 (1)
    nonidet p40 53.8 3 1835378 (2), 9105092 (1)
    glucosamine 42.4 2 1313004 (1), 10545222 (1)
    suramin 41.4 4 8917344 (2), 9572679 (1), 15893415 (1)
    dextran sulfate 37 1 8081252 (1)
    phosphatidylinositol 35.8 3 1313004 (1), 8917344 (1), 15620691 (1)

    Search CenterWatch for drugs/clinical trials and news about GPLD1 / PHLD 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for GPLD1 gene (2 alternative transcripts): 
    NM_001503.3  NM_177483.1  

    Unigene Cluster for GPLD1:

    Glycosylphosphatidylinositol specific phospholipase D1
    Hs.533291  [show with all ESTs]
    Unigene Representative Sequence: NM_001503
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000492917 ENST00000230036(uc003ned.1 uc010jpr.1 uc010jps.1)
    ENST00000474784 ENST00000378243(uc003nee.3) ENST00000486892 ENST00000475417


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    Additional cDNA sequence: 

    AJ308108.1 AK308639.1 AK310692.1 AY007546.2 BC007614.1 BC093645.1 BC112001.1 L11702.1 

    10 DOTS entries:

    DT.95089672  DT.413838  DT.92432297  DT.408975  DT.95103805  DT.92432302  DT.40123141  DT.115600 
    DT.40257315  DT.431855 

    24/84 AceView cDNA sequences (see all 84):

    AA012836 AA211064 CR593011 AA001930 AI298868 BX105085 NM_177483 BC007614 
    BM909421 NM_001503 CA391396 BQ059617 AY007546 AI215921 BG199312 AI797022 
    BE168420 BG565942 BV200256 BF433240 BQ642460 AJ308108 BE468248 R10588 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for GPLD1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^
    SP1:                                                  -     -                                                           -                                       
    SP2:                                                                                                                                                            
    SP3:                    -                                                                                                                                       
    SP4:                                                                                                                                                            

    ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    


    ECgene alternative splicing isoforms for GPLD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GPLD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See GPLD1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GPLD1

    SOURCE GeneReport for Unigene cluster: Hs.533291
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for GPLD1 gene from 3/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpld11 , 5 glycosylphosphatidylinositol specific phospholipase D1 less1, 5 80.4(n)1
    79.29(a)1
      13 (10.79 cM)5
    147561  NM_008156.21  NP_032182.21 
     249431525 
    chicken
    (Gallus gallus)
    Aves GPLD11 glycosylphosphatidylinositol specific phospholipase D1 less 65.93(n)
    62.48(a)
      420819  XM_418910.3  XP_418910.3 
    lizard
    (Anolis carolinensis)
    Reptilia GPLD16
    --
    59(a)
    1 ↔ 1
    4(54051722-54088608)


    ENSEMBL Gene Tree for GPLD1 (if available)
    TreeFam Gene Tree for GPLD1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1850 NCBI SNPs in GPLD1 are shown (see all 1850    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs749243711,2
    --24376018(+) TAAATC/TGTGAG 1 -- ut311Minor allele frequency- T:0.01WA 118
    rs728330711,2
    C,--24376117(+) GACCCA/CGTACT 1 -- ut310--------
    rs753428471,2
    F,--24376993(+) AAAAGG/CTATTA 1 -- ut311Minor allele frequency- C:0.03WA 118
    rs1132047811,2
    C--24377517(+) GAACCA/C/TAAAAT 2 -- ut311CSA 1
    rs94671401,2
    H--24377697(+) GTTCAA/CCTttt 1 -- ut314Minor allele frequency- C:0.00NS EA 398
    rs1161932661,2
    C,F,--24378095(+) AGAGAC/TTGTTC 1 -- ut311Minor allele frequency- T:0.03NA 120
    rs94671411,2
    --24379063(+) gtgcaA/Gtgatg 1 -- int10--------
    rs561484391,2
    C,F,--24379612(+) TCTACA/GCTTAA 1 -- int13Minor allele frequency- G:0.32WA CSA 122
    rs778851281,2
    F,--24380653(+) CTAGAG/AGGCAG 1 -- int11Minor allele frequency- A:0.03WA 118
    rs121920981,2
    C--24380991(+) TAAACT/Attttt 1 -- int1 trp31Minor allele frequency- A:0.50NA 2

    HapMap Linkage Disequilibrium report for GPLD1 (24424793 - 24495433 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for GPLD1
         3 CNVs: 47969 59316 51863

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GPLD1
    DNA2.0 Custom Variant and Variant Library Synthesis for GPLD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    GPLD1 for disorders           About GeneDecksing

    OMIM gene information: 602515    OMIM disorders: --

    20/22 diseases for GPLD1 (see all 22):    About MalaCards
    paroxysmal nocturnal hemoglobinuria    pre-eclampsia    myeloid leukemia    insulin resistance
    hemoglobinuria    fatty liver disease    liver disease    chronic myeloid leukemia
    acute myeloid leukemia    eclampsia    pulmonary fibrosis    neurofibromatosis
    leukemia    fibrosis    pertussis    hepatocellular carcinoma
    colon cancer    carcinoma    atherosclerosis    obesity

    8 Novoseek disease relationships for GPLD1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloid leukemia 27 3 15972122 (2)
    colon carcinoma 15.8 1 15893415 (1)
    liver diseases 4.93 1 16595594 (1)
    insulin resistance 2.86 7 14767861 (2), 18328347 (1), 16595594 (1)
    leukemia 0 8 16562670 (4), 15907827 (1), 20137110 (1)
    necrosis 0 5 11292743 (1), 10359731 (1)
    tumors 0 15 17467053 (2), 1815506 (1), 11292743 (1), 17368745 (1) (see all 5)
    cancer 0 4 18830568 (1), 8917344 (1), 10395292 (1)

    Human Genome Epidemiology (HuGE) Navigator: GPLD1 (4 documents)

    Export disorders for GPLD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GPLD1 gene, integrated from 9 sources (see all 107):
    (articles sorted by number of sources associating them with GPLD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and expression of the human glycosylphosphatidylinositol phospholipase D1 (GPLD1) gene. (PubMed id 11072085)1, 2, 3, 9 Schofield J.N. and Rademacher T.W. (2000)
    2. Phosphatidylinositol-glycan-specific phospholipase D is an amphiphilic glycoprotein that in serum is associated with high-density lipoproteins. (PubMed id 1606959)1, 2, 9 Hoener M.C. and Brodbeck U. (1992)
    3. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    6. Phosphorylation decreases trypsin activation and apolipoprotein al binding to glycosylphosphatidylinositol-specific phospholipase D. (PubMed id 11989719)1, 9 Deeg M.A. and Bowen R.F. (2002)
    7. Effect of glycosylphosphatidylinositol specific phospholipase D gene expression levels on complement mediated killing of leukemic cells in patients with chronic myeloid leukemia. (PubMed id 15907827)1, 9 Jian-Hua T....Gui-Yuan L. (2005)
    8. GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex. (PubMed id 11254757)1, 9 Deeg M.A....Cheung M.C. (2001)
    9. Production of the glycosylphosphatidylinositol-specific phospholipase D by the islets of Langerhans. (PubMed id 1833386)1, 9 Metz C.N....Davitz M.A. (1991)
    10. [Expression and activity of glycosylphosphatidilinodi tol-specific phospholipase d mRNA in bone marrow mononuclear cells isolated fro m patient with acute myeloid leukemia and their significance] (PubMed id 20137110)1, 9 Xiao G.F....Zeng C. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2822 HGNC: 4459 AceView: GPLD1 Ensembl:ENSG00000112293 euGenes: HUgn2822
    ECgene: GPLD1 Kegg: 2822 H-InvDB: GPLD1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GPLD1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GPLD1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GPLD1 gene:
    Search GeneIP for patents involving GPLD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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