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GPLD1 Gene

protein-coding   GIFtS: 59
GCID: GC06M024425

Glycosylphosphatidylinositol Specific Phospholipase D1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glycosylphosphatidylinositol Specific Phospholipase D11 2     GPIPLD2 5
Glycoprotein Phospholipase D2 3     PIGPLD2 5
GPI-PLD2 3     GPIPLDM2
PIGPLD12 3     PLD2
GPI-Specific Phospholipase D2 3     Phosphatidylinositol-Glycan-Specific Phospholipase D2
PI-G PLD2 3     Glycosyl-Phosphatidylinositol-Specific Phospholipase D3
EC 3.1.4.503 8     

External Ids:    HGNC: 44591   Entrez Gene: 28222   Ensembl: ENSG000001122937   OMIM: 6025155   UniProtKB: P801083   

Export aliases for GPLD1 gene to outside databases

Previous GC identifers: GC06M024485 GC06M024536 GC06M024377


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GPLD1 Gene:
Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a
glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein
encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes
the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the
attached protein from the plasma membrane. (provided by RefSeq, Jul 2008)

GeneCards Summary for GPLD1 Gene:
GPLD1 (glycosylphosphatidylinositol specific phospholipase D1) is a protein-coding gene. GO annotations related to this gene include sodium channel regulator activity and glycosylphosphatidylinositol phospholipase D activity.

UniProtKB/Swiss-Prot: PHLD_HUMAN, P80108
Function: This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol
glycans (GPI-anchor) thus releasing these proteins from the membrane

Gene Wiki entry for GPLD1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GPLD1 gene promoter:
         RFX1   p53   Meis-1a   Meis-1b   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPLD1 promoter sequence
   Search Chromatin IP Primers for GPLD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GPLD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.3   HGNC cytogenetic band: 6p22.1

GPLD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPLD1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M024425:  view genomic region     (about GC identifiers)

Start:
24,424,793 bp from pter      End:
24,495,433 bp from pter
Size:
70,641 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PHLD_HUMAN, P80108 (See protein sequence)
Recommended Name: Phosphatidylinositol-glycan-specific phospholipase D precursor  
Size: 840 amino acids; 92336 Da
Subunit: Monomer (Potential)
Sequence caution: Sequence=AAA36444.1; Type=Miscellaneous discrepancy; Note=This sequence has numerous of
conflicts with the human genome;
Secondary accessions: Q15127 Q15128 Q2M2F2 Q5T3Y0 Q7Z6T8 Q8TCV0 Q8WW82 Q96ID6 Q9H167 Q9H4M1
Q9UJC9
Alternative splicing: 2 isoforms:  P80108-1   P80108-2   

Explore the universe of human proteins at neXtProt for GPLD1: NX_P80108

Explore proteomics data for GPLD1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn94, Asn271, Asn292, Asn307, Asn321, Asn501, Asn568, Asn591, Asn604, Asn659
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for GPLD1 (P80108)
     DGLDEII  HQDAYQAG  CNLPENPLFI  AGDFGGDVLSQFEF 


    See GPLD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001494.2  
    ENSEMBL proteins: 
     ENSP00000230036  

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    Cloud-Clone Corp. Proteins for GPLD1

     
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    antibodies-online proteins for GPLD1 (2 products) 

     
    antibodies-online peptides for GPLD1

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    antibodies-online antibodies for GPLD1 (39 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR013519 Int_alpha_beta-p
     IPR013517 FG-GAP
     IPR001028 Gprt_PLipase_D

    Graphical View of Domain Structure for InterPro Entry P80108

    ProtoNet protein and cluster: P80108

    1 Blocks protein domain: IPB001028 Phospholipase D signature

    UniProtKB/Swiss-Prot: PHLD_HUMAN, P80108
    Similarity: Belongs to the GPLD1 family
    Similarity: Contains 7 FG-GAP repeats


    Find genes that share domains with GPLD1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PHLD_HUMAN, P80108
    Function: This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol
    glycans (GPI-anchor) thus releasing these proteins from the membrane
    Catalytic activity: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(2)O =
    6-(alpha-D-glucosaminyl)-1D-myo-inositol + phosphatidate

         Enzyme Number (IUBMB): EC 3.1.4.501 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004621glycosylphosphatidylinositol phospholipase D activity TAS2017684
    GO:0004630phospholipase D activity IDA2760042
    GO:0017080sodium channel regulator activity ISS--
         
    Find genes that share ontologies with GPLD1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for GPLD1

    miRNA
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    miRTarBase miRNAs that target GPLD1:
    hsa-mir-505-3p (MIRT040991)

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    3 qRT-PCR Assays for microRNAs that regulate GPLD1:
    hsa-miR-9* hsa-miR-3613-3p hsa-miR-2355-3p
    SwitchGear 3'UTR luciferase reporter plasmidGPLD1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PHLD_HUMAN, P80108: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol2
    plasma membrane2
    lysosome1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix ISS--
    GO:0005615extracellular space IDA15907827
    GO:0005622intracellular IDA15907827
    GO:0005737cytoplasm ISS--
    GO:0005765lysosomal membrane IDA17897319

    Find genes that share ontologies with GPLD1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GPLD1 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Post-translational modification- synthesis of GPI-anchored proteins
    Glycosylphosphatidylinositol(GPI)-anchor biosynthesis0.76
    2GPCR Pathway
    Ras Pathway0.73
    3PAK Pathway
    Antioxidant Action of Vitamin-C0.56
    4Phospholipase-C Pathway
    Phospholipase-C Pathway0.56
    5p70S6K Signaling
    mTOR Pathway0.54


    Find genes that share SuperPaths with GPLD1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GPLD1 (see all 8)
        FGF Pathway
    Endothelin-1 Signaling Pathway
    Antioxidant Action of Vitamin-C
    Sperm Motility
    Phospholipase-C Pathway


    1 Kegg Pathway  (Kegg details for GPLD1):
        Glycosylphosphatidylinositol(GPI)-anchor biosynthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GPLD1
    Interactions:

        GeneGlobe Interaction Network for GPLD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for GPLD1 (P801083 ENSP000002300364) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD55P081743, ENSP000003163334I2D: score=2 STRING: ENSP00000316333
    GM2AP179003, ENSP000003496874I2D: score=2 STRING: ENSP00000349687
    ALPPP051873, ENSP000003758814I2D: score=1 STRING: ENSP00000375881
    APOA1P026473, ENSP000002368504I2D: score=2 STRING: ENSP00000236850
    PIGLENSP000002256094STRING: ENSP00000225609
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 30):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification ISS--
    GO:0002042cell migration involved in sprouting angiogenesis IMP17720976
    GO:0002062chondrocyte differentiation ISS--
    GO:0002430complement receptor mediated signaling pathway IDA15907827
    GO:0006507GPI anchor release IMP17720976

    Find genes that share ontologies with GPLD1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GPLD1 (PHLD)

    Selected HMDB Compounds for GPLD1 (see all 18)    About this table
    CompoundSynonyms CAS #PubMed Ids
    LPA(0:0/16:0)Lysophosphatidic acid(16:0) (see all 6)----
    LPA(0:0/18:0)2-octadecanoyl-phosphatidic acid (see all 6)----
    LPA(0:0/18:1(9Z))LPA(18:1) (see all 10)----
    LPA(0:0/18:2(9Z,12Z))LPA(0:0/18:2n6) (see all 10)----
    LPA(16:0/0:0)Lysophosphatidic acid(16:0/0:0) (see all 14)----
    LPA(18:0/0:0)1-octadecanoyl-phosphatidic acid (see all 6)----
    LPA(18:1(9Z)/0:0)1-oleoyl-glycero-3-phosphate (see all 26)----
    LPA(18:2(9Z,12Z)/0:0)LPA(18:2w6/0:0) (see all 10)----
    PA(16:0/16:0)Dipalmitoylphosphatidic acid (see all 25)7091-44-3--
    PA(16:0/18:1(11Z))PA(16:0/18:1n7) (see all 10)----

    Selected Novoseek inferred chemical compound relationships for GPLD1 gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glyceryl monooleate 65.9 2 10591409 (2)
    sodium nitrite 62.2 4 1708886 (1), 1378620 (1), 8300589 (1), 9144552 (1)
    inositol 59 2 1313004 (1), 7651182 (1)
    monoacylglycerol 54.2 2 10591409 (1)
    1,10-phenanthroline 53.9 4 17467053 (1), 14611645 (1), 7512501 (1), 15893415 (1)
    nonidet p40 53.8 3 1835378 (2), 9105092 (1)
    glucosamine 42.4 2 1313004 (1), 10545222 (1)
    suramin 41.4 4 8917344 (2), 9572679 (1), 15893415 (1)
    dextran sulfate 37 1 8081252 (1)
    phosphatidylinositol 35.8 3 1313004 (1), 8917344 (1), 15620691 (1)



    Find genes that share compounds with GPLD1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GPLD1 gene (2 alternative transcripts): 
    NM_001503.3  NM_177483.1  

    Unigene Cluster for GPLD1:

    Glycosylphosphatidylinositol specific phospholipase D1
    Hs.533291  [show with all ESTs]
    Unigene Representative Sequence: NM_001503
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000492917 ENST00000230036(uc003ned.1 uc010jpr.1 uc010jps.1)
    ENST00000474784 ENST00000378243(uc003nee.3) ENST00000486892 ENST00000475417

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    hsa-miR-9* hsa-miR-3613-3p hsa-miR-2355-3p
    SwitchGear 3'UTR luciferase reporter plasmidGPLD1 3' UTR sequence
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    Additional mRNA sequence: 

    AJ308108.1 AK308639.1 AK310692.1 AY007546.2 BC007614.1 BC093645.1 BC112001.1 L11702.1 

    9 DOTS entries:

    DT.95089672  DT.413838  DT.92432297  DT.408975  DT.95103805  DT.92432302  DT.40123141  DT.40257315 
    DT.431855 

    Selected AceView cDNA sequences (see all 84):

    BM909421 NM_001503 BQ059617 BC007614 CR593011 AA211064 AY007546 NM_177483 
    AI298868 AA012836 CA391396 AA001930 BX105085 R10588 BE168420 BG562713 
    AI802084 L11702 N69672 BF433240 BM458510 AI340047 AI300016 BQ066223 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for GPLD1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^
    SP1:                                                  -     -                                                           -                                       
    SP2:                                                                                                                                                            
    SP3:                    -                                                                                                                                       
    SP4:                                                                                                                                                            

    ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    


    ECgene alternative splicing isoforms for GPLD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GPLD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GPLD1 Expression
    About this image


    GPLD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Medulla Oblongata
     
     Germ Cells (Reproductive System)
             Primordial germ cell-like cells
     
     Gonad
             Primordial germ cell-like cells
     
     Liver (Hepatobiliary System)
    GPLD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GPLD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.533291
        Custom PCR Arrays for GPLD1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPLD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for GPLD1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpld11 , 5 glycosylphosphatidylinositol specific phospholipase more1, 5 80.4(n)1
    79.29(a)1
      13 (10.79 cM)5
    147561  NM_008156.21  NP_032182.21 
     249431525 
    chicken
    (Gallus gallus)
    Aves GPLD11 glycosylphosphatidylinositol specific phospholipase more 65.83(n)
    62.16(a)
      420819  XM_418910.4  XP_418910.4 
    lizard
    (Anolis carolinensis)
    Reptilia GPLD16
    glycosylphosphatidylinositol specific phospholipas...
    59(a)
    1 ↔ 1
    4(54051722-54088878)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004933391 phosphatidylinositol-glycan-specific phospholipase more 63.94(n)
    59.96(a)
      100493339  XM_002937922.2  XP_002937968.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YJL132W)4 Putative protein of unknown function; localizes to more   --   10(161914-164166) 853309  NP_012403.1 


    ENSEMBL Gene Tree for GPLD1 (if available)
    TreeFam Gene Tree for GPLD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GPLD1 (see all 2283)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37477721,2
    C,F--24347506(-) AAAAAA/TTTATT 1 -- ds50012Minor allele frequency- T:0.17NA EA 240
    rs37477711,2
    C,F,A,H--24347568(-) CTTCCT/CTTTAT 1 -- ds50019Minor allele frequency- C:0.14NA NS EA 794
    rs1402513331,2
    --24347574(+) GGAAGC/TTGCTA 1 -- ds50010--------
    rs34691,2
    C,F,H--24347587(-) TTCTAT/CAAAAC 1 -- ds500112Minor allele frequency- C:0.10MN NA NS EA WA 1088
    rs1503628091,2
    --24347683(+) TTCTCA/CTAAAT 1 -- ds50010--------
    rs37477691,2
    C,F,A--24347757(-) ATGTGC/ATCAGT 1 -- ds50015Minor allele frequency- A:0.36NA WA EA 362
    rs37477681,2
    C,F,A--24347758(-) AATGTG/ACTCAG 1 -- ds50015Minor allele frequency- A:0.37NA WA EA 362
    rs38276401,2
    C,F,A,H--24347832(-) GTGTTC/TGACAG 1 -- ds500129Minor allele frequency- T:0.42EA NA NS WA 3990
    rs1927633281,2
    --24347847(+) AGTGTC/TGAACA 1 -- ds50010--------
    rs412717811,2
    C,F--24347854(+) AACACG/ATCAAG 1 -- ds50012Minor allele frequency- A:0.17NA EA 240

    HapMap Linkage Disequilibrium report for GPLD1 (24424793 - 24495433 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for GPLD1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2229610CNV Deletion18987734
    esv2731712CNV Deletion23290073
    nsv515988CNV Loss19592680
    nsv883480CNV Loss21882294
    nsv525943CNV Loss19592680
    esv34020CNV Loss18971310
    nsv820266CNV Gain19587683
    nsv519552CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GPLD1
    DNA2.0 Custom Variant and Variant Library Synthesis for GPLD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602515    OMIM disorders: --


    Find genes that share disorders with GPLD1           About GenesLikeMe

    8 Novoseek inferred disease relationships for GPLD1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloid leukemia 27 3 15972122 (2)
    colon carcinoma 15.8 1 15893415 (1)
    liver diseases 4.93 1 16595594 (1)
    insulin resistance 2.86 7 14767861 (2), 18328347 (1), 16595594 (1)
    leukemia 0 8 16562670 (4), 15907827 (1), 20137110 (1)
    necrosis 0 5 11292743 (1), 10359731 (1)
    tumors 0 15 17467053 (2), 1815506 (1), 11292743 (1), 17368745 (1) (see all 5)
    cancer 0 4 18830568 (1), 8917344 (1), 10395292 (1)

    Genetic Association Database (GAD): GPLD1
    Human Genome Epidemiology (HuGE) Navigator: GPLD1 (4 documents)

    Export disorders for GPLD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GPLD1 gene, integrated from 10 sources (see all 113):
    (articles sorted by number of sources associating them with GPLD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and expression of the human glycosylphosphatidylinositol phospholipase D1 (GPLD1) gene. (PubMed id 11072085)1, 2, 3, 9 Schofield J.N. and Rademacher T.W. (Biochim. Biophys. Acta 2000)
    2. Phosphatidylinositol-glycan-specific phospholipase D is an amphiphilic glycoprotein that in serum is associated with high-density lipoproteins. (PubMed id 1606959)1, 2, 9 Hoener M.C. and Brodbeck U. (Eur. J. Biochem. 1992)
    3. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (PubMed id 22001757)1, 4 Chambers J.C....Kooner J.S. (Nat. Genet. 2011)
    4. PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease. (PubMed id 20648472)1, 4 Speliotes E.K....Hirschhorn J.N. (Hepatology 2010)
    5. Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. (PubMed id 18940312)1, 4 Yuan X....Mooser V. (Am. J. Hum. Genet. 2008)
    6. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    9. Phosphorylation decreases trypsin activation and apolipoprotein al binding to glycosylphosphatidylinositol-specific phospholipase D. (PubMed id 11989719)1, 9 Deeg M.A. and Bowen R.F. (Biochem. Cell Biol. 2002)
    10. Effect of glycosylphosphatidylinositol specific phospholipase D gene expression levels on complement mediated killing of leukemic cells in patients with chronic myeloid leukemia. (PubMed id 15907827)1, 9 Jian-Hua T....Gui-Yuan L. ( international journal of clinical chemistry 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2822 HGNC: 4459 AceView: GPLD1 Ensembl:ENSG00000112293 euGenes: HUgn2822
    ECgene: GPLD1 Kegg: 2822 H-InvDB: GPLD1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GPLD1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GPLD1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for GPLD1 gene:
    Search GeneIP for patents involving GPLD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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