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GPLD1 Gene

protein-coding GIFtS: 59

GC06M024536

glycosylphosphatidylinositol specific phospholipase D1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 3.1.4.50 ^³
GPI-PLD ^³
GPIPLD ^², ⁵
GPIPLDM ^²
MGC22590 ^²
OTTHUMP00000017721 ^²
OTTHUMP00000017722 ^²
OTTHUMP00000039407 ^²
PIGPLD ^², ⁵
PIGPLD1 ^², ³

Descriptions
GPI-specific phospholipase D ^², ³
Glycoprotein phospholipase D ^², ³
Glycosyl-phosphatidylinositol-specific phospholipase D ^³
PI-G PLD ^³
glycosylphosphatIdylinositol-specific phospholipase D ^²
glycosylphosphatidylinositol specific phospholipase D1 ^²
glycosylphosphatidylinositol specific phospholipase D1, isoform 2 ^²
phospholipase D, phosphatidylinositol-glycan-specific ^²

External Ids
HGNC: 4459¹
Entrez Gene: 2822²
UniProtKB: P80108³
Ensembl: ENSG00000112293⁷

Search outside databases for aliases for GPLD1 gene

Previous GC identifer: GC06M024485

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for GPLD1:

Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a

glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood

cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol

specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by

phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane.

[provided by RefSeq]

UniProtKB/Swiss-Prot: PHLD_HUMAN, P80108

Function: This protein hydrolyzes the inositol phosphate linkage in proteins anchored by

phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane

Gene Wiki entry for GPLD1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GPLD1 gene

Entrez Gene cytogenetic band: 6p22.3-p22.2 Ensembl cytogenetic band: 6p22.2 HGNC cytogenetic band: 6p22.1

GPLD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M024536: (about GC identifiers)

Start:	24,536,384 bp from pter
End:	24,597,829 bp from pter
Size:	61,446 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000006.10 NT_007592.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: PHLD_HUMAN, P80108 (See protein sequence)

Recommended Name: Phosphatidylinositol-glycan-specific phospholipase D precursor

Size: 840 amino acids; 92336 Da

Subunit: Monomer (Potential)

Subcellular location: Secreted

Sequence caution: Sequence=AAA36444.1; Type=Miscellaneous discrepancy; Note=This sequence has

numerous of conflicts with the human genome;

Secondary accessions: Q15127 Q15128 Q2M2F2 Q5T3Y0 Q7Z6T8 Q8TCV0 Q8WW82 Q96ID6 Q9H167 Q9H4M1 Q9UJC9

Alternative splicing: 2 isoforms: P80108-1 P80108-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001494.2 NP_803436.1

ENSEMBL proteins:

ENSP00000230036 ENSP00000367489

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (GPLD1)
	Human Recombinant Proteins from Abnova (GPLD1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

About this table

Antibodies for GPLD1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for GPLD1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (GPLD1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (GPLD1)
	Novus Biologicals Antibody for GPLD1

Assays for GPLD1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P80108

ProtoNet protein and cluster: P80108

1 Blocks protein family: IPB001028 Phospholipase D signature

UniProtKB/Swiss-Prot: PHLD_HUMAN, P80108

Similarity: Belongs to the GPLD1 family

Similarity: Contains 4 FG-GAP repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GPLD1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_177483

Applied Biosystems Silencer® siRNAs for GPLD1

Sigma-Aldrich siRNA and siRNA Panels for GPLD1

Sigma-Aldrich shRNA for GPLD1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for GPLD1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001503
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001503
untagged cDNA clones in CMV expression vector (see all 3): NM_001503

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001503

UniProtKB/Swiss-Prot: PHLD_HUMAN, P80108

Function: This protein hydrolyzes the inositol phosphate linkage in proteins anchored by

phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane

Catalytic activity: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(2)O =

6-(alpha-D-glucosaminyl)-1D-myo-inositol + phosphatidate

Enzyme Number (IUBMB): EC 3.1.4.50

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004621	glycosylphosphatidylinositol phospholipase D activity	IEA	--
GO:0016787	hydrolase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5 Sigma-Aldrich "Your Favorite Gene" Pathways for GPLD1 (Your Favorite Gene powered by Ingenuity)

IL-8 Signaling
Glycerophospholipid Metabolism
Fc&gamma
Phospholipid Degradation
Endothelin-1 Signaling

GeneDecks GPLD1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for GPLD1

5/14 Interacting proteins for GPLD1 (ENSP00000230036³) via UniProtKB, MINT, and/or STRING (see all 14 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PLD1	ENSP00000342793³	STRING (score=.917)
AKAP5	ENSP00000315615³	STRING (score=.899)
COPA	ENSP00000357048³	STRING (score=.899)
FAM118A	ENSP00000216214³	STRING (score=.899)
FBXW10	ENSP00000310382³	STRING (score=.899)

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for GPLD1
10/12 Novoseek chemical compound relationships for GPLD1 gene (see all 12 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
sodium nitrite	62.80	4	1708886 (1), 1378620 (1), 8300589 (1), 9144552 (1)
1,10-phenanthroline	54.77	4	17467053 (1), 14611645 (1), 7512501 (1), 15893415 (1)
phosphatidylinositol	36.72	3	1313004 (1), 8917344 (1), 15620691 (1)
agarose	20.53	1	8081252 (1)
lipid	20.11	6	1396675 (1), 17761367 (1), 14611645 (1), 7908190 (1) (see all 5)
sialic acid	16.22	2	7670541 (1)
polyacrylamide	15.50	1	8081252 (1)
cholesterol	6.81	7	10486566 (1), 11254757 (1), 17761367 (1), 8081252 (1) (see all 6)
phospholipid	0.00	1	1835378 (1)
glucose	0.00	4	16114550 (2), 15907827 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GPLD1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_177483

Sigma-Aldrich siRNA and siRNA Panels for GPLD1

Sigma-Aldrich shRNA for GPLD1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001503 NM_177483

REFSEQ mRNAs for GPLD1 gene (2 alternative transcripts):

NM_001503.2 NM_177483.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001503 NM_177483

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001503
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001503
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001503

Additional cDNA sequence:

AJ308108.1 AK308639.1 AK310692.1 AY007546.2 BC007614.1 BC020748.1 BC093645.1 BC112001.1

CR593011.1 L11702.1

10 DOTS entries:

DT.95089672 DT.95103805 DT.92432297 DT.115600 DT.413838 DT.92432302 DT.40257315 DT.100791420

DT.121374255 DT.431855

24/84 AceView cDNA sequences (see all 84 ):

AA012836 NM_177483 NM_001503 BM909421 AA001930 AA211064 CA391396 CR593011

BX105085 AY007546 BQ059617 AI298868 BC007614 AJ308108 AI300016 BQ066223

AI797022 BE674158 BM458510 BV200256 BG562713 CD244981 BE468248 BQ642460

highest scoring ESTs for GPLD1:

L11702 AA001730 AI040379 AJ308108 AY007546 BC020748 BG565942 AA001930 AA012836 AA211064

Unigene Cluster for GPLD1:

Glycosylphosphatidylinositol specific phospholipase D1

Hs.533291 [show with all ESTs]

Unigene Representative Sequence: NM_001503

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for GPLD1

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6a	·	6b	·	6c	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14	^	15	^	16a	·	16b	^	17	^	18	^	19	^	20	^
SP1:																	-		-																				-
SP2:
SP3:							-
SP4:

ExUns:	21	^	22	^	23	^	24	^	25	^	26
SP1:
SP2:
SP3:
SP4:

About this scheme

ECgene alternative splicing isoforms for GPLD1

2 Ensembl transcripts including schematic representations:

ENST00000230036 ENST00000378243

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

GPLD1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GPLD1

¹ / ² / ³

14 probe-sets matching GPLD1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1293_s_at²^{, 3}	U95-A	1	1.00	1.00	0.94	0.64	L11701	0.60	1.00	0.82	1
934_at²^{, 3}	U95-A	1	1.00	1.00	0.73	1.61	L11702	1.00	1.00	1.00	1
33017_at²^{, 3}	U95-A	1	1.00	1.00	0.71	0.96	AI040379	0.80	1.00	0.91	1
42657_r_at*²^{, 3}	U95-B	1	--	--	0.61	0.90	H93959	0.40	1.00	0.76	1
206264_at²^{, 3}	U133-A	1	1.00	1.00	--	--	L11702	1.00	1.00	1.00	1
206266_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001503	0.60	1.00	0.82	1
206265_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001503	0.60	1.00	0.82	1
215554_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AV699786	0.60	1.00	0.82	1
217405_x_at²	U133-A	1	0.73	1.00	--	--	--	--	--	--	--
206264_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
206266_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
206265_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
215554_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
217405_x_at²	U133Plus2	1	0.73	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.533291
Expression variation in blood from EXPOLDB for GPLD1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GPLD1 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GPLD1¹	--	glycosylphosphatidylinositol specific phospholipase more	84.55(n) 83.79(a)	478735 XM_535902.2 XP_535902.2
chimpanzee (Pan troglodytes)	GPLD1¹	--	glycosylphosphatidylinositol specific phospholipase more	98.25(n) 97.49(a)	462473 XM_518268.2 XP_518268.2
cow (Bos taurus)	GPLD1¹	--	glycosylphosphatidylinositol specific phospholipase more	84.62(n) 81.88(a)	287025 NM_174816.2 NP_777241.1
rat (Rattus norvegicus)	Gpld1¹	--	glycosylphosphatidylinositol specific phospholipase more	81.31(n) 80.48(a)	291132 XM_214480.2 XP_214480.1
mouse (Mus musculus)	Gpld1^{1, 5}	13 (13.00 cM)⁵	glycosylphosphatidylinositol specific phospholipase more^{1, 5}	80.4(n)¹ 79.29(a)¹	14756¹ NM_008156.2¹ NP_032182.2¹ AF050666⁵ AK004957⁵ (see all 15)

About this table Species with no ortholog for GPLD1

ENSEMBL Gene Tree for GPLD1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/738 NCBI SNPs in GPLD1 are shown (see all 738 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 249)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1126617^1,2	A,C,F,H	24597631(-)	`CACACA/GTAGAA`	2	V/I	mis¹ ese³		13	EA NA EU WA	1232
	rs2744572^1,2	A,C,F,H	24598490(+)	`ATTATT/CAGGTA`	2	--	ng3¹		4	EU EA WA	410
	rs1883415^1,2	A,C,F,H	24599454(+)	`TACAGA/CCTGTG`	2	--	ng3¹		11	EU EA WA NA	888
	rs1042303^1,2	A,C,F,H	24545437(+)	`GTACAT/CGCGAG`	1	V/M	mis¹ ese³		13	MN EA NA WA EU	2572
	rs2076317^1,2	A,C,F,H	24598126(+)	`ATATTA/GGACCA`	2	--	ng3¹		6	EA EU WA	1862
	rs6924628^1,2	A,C,F,H	24562371(+)	`GTCACC/TGTGCC`	1	G/S	mis¹ ese³		11	EU EA WA NA	974
--	rs6942189^1,2	A,C,F,H	24537228(+)	`AAATGC/TAGTGA`	1	--	ut3¹ ese³		12	EA NA EU WA	1024
	rs1772256^1,2	A,C,F,H	24545424(+)	`CAGATA/GTGAGT`	1	T/I	mis¹ ese³		14	MN EU EA WA NA	1196
	rs2076316^1,2	A,C,F,H	24597720(+)	`ACATGA/CTCTCA`	2	--	ut5¹		8	EU EA WA NA	772
	rs17300770^1,2	C,F,H	24570999(+)	`TTGCAG/CTCACT`	1	E/D	mis¹ ese³		16	NA EU EA WA	1462

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HapMap Linkage Disequilibrium images for GPLD1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602515

8 Novoseek disease relationships for GPLD1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
myeloid leukemia	27.84	3	15972122 (2)
colon carcinoma	16.78	1	15893415 (1)
liver diseases	6.59	1	16595594 (1)
insulin resistance	4.87	7	14767861 (2), 18328347 (1), 16595594 (1)
necrosis	0.00	5	11292743 (1), 10359731 (1)
cancer	0.00	4	18830568 (1), 8917344 (1), 10395292 (1)
tumors	0.00	15	17467053 (2), 1815506 (1), 11292743 (1), 17368745 (1) (see all 5)
leukemia	0.00	7	16562670 (4), 15907827 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/99 PubMed articles for GPLD1 gene (see all 99 ):

Structure and expression of the human glycosylphosphatidylinositol phospholipase D1 (GPLD1) gene. (PubMed id 11072085)^{1, 2, 3, 4} Schofield J.N. and Rademacher T.W. (2000)
Phosphatidylinositol-glycan-specific phospholipase D is an amphiphilic glycoprotein that in serum is associated with high-density lipoproteins. (PubMed id 1606959)^{1, 3, 4} Hoener M.C. and Brodbeck U. (1992)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{3, 4} Liu T.... Smith R.D. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{3, 4} Mungall A.J.... Beck S. (2003)
Phosphorylation decreases trypsin activation and apolipoprotein al binding to glycosylphosphatidylinositol-specific phospholipase D. (PubMed id 11989719)^{1, 3} Deeg M.A. and Bowen R.F. (2002)
GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex. (PubMed id 11254757)^{1, 3} Deeg M.A....Cheung M.C. (2001)
Role of glycosylphosphatidylinositol-specific phospholipase D in the homing of umbilical cord blood, mobilized peripheral blood and bone marrow-derived hematopoietic stem/progenitor cells. (PubMed id 17467053)^{1, 3} Song K....Chen F. (2007)
Release of GPI-anchored membrane proteins by a cell-associated GPI-specific phospholipase D. (PubMed id 7512501)^{1, 3} Metz C.N....Davitz M.A. (1994)
[Preliminary study of the gene structure of human glycosylphosphatidylinositol specific phospholipase D] (PubMed id 12536633)^{1, 3} Tang J.H....Zhang X.J. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2822	HGNC: 4459	AceView: GPLD1	Ensembl:ENSG00000112293	euGenes: HUgn2822
ECgene: GPLD1	H-InvDB: GPLD1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for GPLD1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for GPLD1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for GPLD1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GPLD1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GPLD1		Antibodies for GPLD1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for GPLD1		Browse small molecules at Sigma-Aldrich
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Antibodies for GPLD1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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GPLD1 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for GPLD1

Summaries
for GPLD1

Genomic Location
for GPLD1

Proteins
for GPLD1

Protein Domains/
Families
for GPLD1

Gene Function
for GPLD1

Pathways & Interactions
for GPLD1

Drugs & Compounds
for GPLD1

Transcripts
for GPLD1

Expression
for GPLD1

Orthologs
for GPLD1

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for GPLD1

SNPs/Variants
for GPLD1

Disorders & Mutations
for GPLD1

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for GPLD1

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for GPLD1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GPLD1 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor GPLD1

Summariesfor GPLD1

Genomic Locationfor GPLD1

Proteinsfor GPLD1

Protein Domains/Familiesfor GPLD1

Gene Functionfor GPLD1

Pathways & Interactionsfor GPLD1

Drugs & Compoundsfor GPLD1

Transcriptsfor GPLD1

Expression for GPLD1

Orthologsfor GPLD1

Paralogsfor GPLD1

SNPs/Variantsfor GPLD1

Disorders & Mutationsfor GPLD1

Medical Newsfor GPLD1

Publicationsfor GPLD1

Search for GPLD1

Genome Databases showing GPLD1

Other Databases showing GPLD1

Specialized Databases showing GPLD1

Licensable Technologiesfor GPLD1

Servicesfor GPLD1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GPLD1

Summaries
for GPLD1

Genomic Location
for GPLD1

Proteins
for GPLD1

Protein Domains/
Families
for GPLD1

Gene Function
for GPLD1

Pathways & Interactions
for GPLD1

Drugs & Compounds
for GPLD1

Transcripts
for GPLD1

Expression
for GPLD1

Orthologs
for GPLD1

Paralogs
for GPLD1

SNPs/Variants
for GPLD1

Disorders & Mutations
for GPLD1

Medical News
for GPLD1

Publications
for GPLD1

Licensable Technologies
for GPLD1

Services
for GPLD1