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Aliases for GPKOW Gene

Aliases for GPKOW Gene

  • G-Patch Domain And KOW Motifs 2 3 5
  • Protein MOS2 Homolog 3 4
  • GPATCH5 3 4
  • GPATC5 3 4
  • T54 3 4
  • G Patch Domain And KOW Motifs-Containing Protein 3
  • G Patch Domain-Containing Protein 5 4
  • G Patch Domain Containing 5 2
  • Protein T54 4
  • Spp2 3

External Ids for GPKOW Gene

Previous GeneCards Identifiers for GPKOW Gene

  • GC0XM047997
  • GC0XM048726
  • GC0XM048857
  • GC0XM048970
  • GC0XM046625

Summaries for GPKOW Gene

Entrez Gene Summary for GPKOW Gene

  • This gene encodes a putative RNA-binding protein containing G-patch and KOW (Kyprides, Ouzounis, Woese) domains. The encoded protein interacts directly with protein kinase A and protein kinase X and is also found associated with the spliceosome. [provided by RefSeq, Aug 2013]

GeneCards Summary for GPKOW Gene

GPKOW (G-Patch Domain And KOW Motifs) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include nucleic acid binding.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPKOW Gene

Genomics for GPKOW Gene

Regulatory Elements for GPKOW Gene

Enhancers for GPKOW Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF049146 1 Ensembl ENCODE 18.5 -24.4 -24438 2.7 ELF3 TBP HDAC1 PKNOX1 ARNT TBL1XR1 NFRKB CHAMP1 ZNF335 GATA2 GPKOW PLP2 RN7SL262P PIR61093
GH0XF049029 0.2 ENCODE 13.1 +93.7 93670 1.5 KLF1 GPKOW WDR45 TFE3 GC0XM049007
GH0XF048954 0.8 Ensembl ENCODE 12.4 +165.0 165033 8.1 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF143 GPKOW PIM2 SLC35A2 ENSG00000204620 WAS PCSK1N ENSG00000228343 KCND1 GRIPAP1 RNU6-722P
GH0XF049176 0.7 ENCODE 12 -53.3 -53262 1.9 CTCF KLF1 KLF17 MAX CDC5L ZIC2 RAD21 SMC3 KLF7 KLF8 GPKOW PLP2 PRICKLE3
GH0XF049103 0.4 ENCODE 6.2 +19.9 19935 1.5 HDAC1 LEF1 ATF1 ZNF792 KLF17 ZNF384 ZIC2 RARA ZNF121 GATA2 PRAF2 GPKOW WDR45
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GPKOW on UCSC Golden Path with GeneCards custom track

Promoters for GPKOW Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for GPKOW Gene

49,113,385 bp from pter
49,123,801 bp from pter
10,417 bases
Minus strand

Genomic View for GPKOW Gene

Genes around GPKOW on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPKOW Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPKOW Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPKOW Gene

Proteins for GPKOW Gene

  • Protein details for GPKOW Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G patch domain and KOW motifs-containing protein
    Protein Accession:
    Secondary Accessions:
    • Q59EK5
    • Q9BQA8

    Protein attributes for GPKOW Gene

    476 amino acids
    Molecular mass:
    52229 Da
    Quaternary structure:
    • Interacts with PRKX.
    • Sequence=AAB18640.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

neXtProt entry for GPKOW Gene

Post-translational modifications for GPKOW Gene

  • Ubiquitination at Lys 192, Lys 299, Lys 315, and Lys 372
  • Modification sites at PhosphoSitePlus

Other Protein References for GPKOW Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for GPKOW
  • Santa Cruz Biotechnology (SCBT) Antibodies for GPKOW

No data available for DME Specific Peptides for GPKOW Gene

Domains & Families for GPKOW Gene

Gene Families for GPKOW Gene

Protein Domains for GPKOW Gene

Suggested Antigen Peptide Sequences for GPKOW Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 G-patch domain.
  • Belongs to the MOS2 family.
  • Contains 1 G-patch domain.
  • Contains 2 KOW domains.
  • Belongs to the MOS2 family.
genes like me logo Genes that share domains with GPKOW: view

Function for GPKOW Gene

Gene Ontology (GO) - Molecular Function for GPKOW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 16491121
genes like me logo Genes that share ontologies with GPKOW: view
genes like me logo Genes that share phenotypes with GPKOW: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPKOW Gene

Localization for GPKOW Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPKOW Gene

Subcellular locations from

Jensen Localization Image for GPKOW Gene COMPARTMENTS Subcellular localization image for GPKOW gene
Compartment Confidence
nucleus 5
cytosol 3
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GPKOW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with GPKOW: view

Pathways & Interactions for GPKOW Gene

genes like me logo Genes that share pathways with GPKOW: view

Pathways by source for GPKOW Gene

Gene Ontology (GO) - Biological Process for GPKOW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with GPKOW: view

No data available for SIGNOR curated interactions for GPKOW Gene

Transcripts for GPKOW Gene

mRNA/cDNA for GPKOW Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(252) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPKOW Gene

G patch domain and KOW motifs:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPKOW Gene

No ASD Table

Relevant External Links for GPKOW Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPKOW Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPKOW Gene

Protein differential expression in normal tissues from HIPED for GPKOW Gene

This gene is overexpressed in Cervix (11.8), Peripheral blood mononuclear cells (9.5), and Lymph node (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GPKOW Gene

Protein tissue co-expression partners for GPKOW Gene

NURSA nuclear receptor signaling pathways regulating expression of GPKOW Gene:


SOURCE GeneReport for Unigene cluster for GPKOW Gene:

genes like me logo Genes that share expression patterns with GPKOW: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GPKOW Gene

Orthologs for GPKOW Gene

This gene was present in the common ancestor of animals.

Orthologs for GPKOW Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPKOW 34 35
  • 87.09 (n)
(Canis familiaris)
Mammalia GPKOW 34 35
  • 86.62 (n)
(Rattus norvegicus)
Mammalia Gpkow 34
  • 80.59 (n)
(Mus musculus)
Mammalia Gpkow 34 16 35
  • 80.23 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 60 (a)
-- 35
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia GPKOW 35
  • 45 (a)
(Anolis carolinensis)
Reptilia GPKOW 35
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11083 34
(Danio rerio)
Actinopterygii gpkow 34 35
  • 56.8 (n)
mpzf637-1-001655 34
fruit fly
(Drosophila melanogaster)
Insecta CG10324 35
  • 19 (a)
(Caenorhabditis elegans)
Secernentea R11A8.2 34 35
  • 41.14 (n)
F53B2.1 35
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 32 (a)
Species where no ortholog for GPKOW was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPKOW Gene

Gene Tree for GPKOW (if available)
Gene Tree for GPKOW (if available)

Paralogs for GPKOW Gene

No data available for Paralogs for GPKOW Gene

Variants for GPKOW Gene

Sequence variations from dbSNP and Humsavar for GPKOW Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs111381639 -- 49,114,736(+) CTTGG(C/T)CAATA intron-variant
rs111658153 -- 49,119,337(+) CTCCT(A/G)GAGTT intron-variant
rs111659143 -- 49,114,937(+) AAAAA(A/G)AAAAA intron-variant
rs111664320 -- 49,114,667(+) CACGC(C/T)TGTAA intron-variant
rs112239364 -- 49,126,143(+) AAATT(-/A)AAAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GPKOW Gene

Variant ID Type Subtype PubMed ID
esv1526582 CNV insertion 17803354
esv32909 CNV gain+loss 17666407
nsv204 OTHER inversion 15895083
nsv528292 CNV gain 19592680
nsv7442 OTHER inversion 18451855

Variation tolerance for GPKOW Gene

Residual Variation Intolerance Score: 78.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.07; 21.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPKOW Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPKOW Gene

Disorders for GPKOW Gene

Relevant External Links for GPKOW

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GPKOW Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPKOW Gene

Publications for GPKOW Gene

  1. Dynamic protein-protein interaction wiring of the human spliceosome. (PMID: 22365833) Hegele A. … Stelzl U. (Mol. Cell 2012) 2 3 64
  2. G-patch domain and KOW motifs-containing protein, GPKOW; a nuclear RNA-binding protein regulated by protein kinase A. (PMID: 21880142) Aksaas A.K. … SkAYlhegg B.S. (J Mol Signal 2011) 2 3 64
  3. Smad6 is a protein kinase X phosphorylation substrate and is required for HL-60 cell differentiation. (PMID: 16491121) Glesne D. … Huberman E. (Oncogene 2006) 3 4 64
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for GPKOW Gene

Sources for GPKOW Gene

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