Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GPKOW Gene

Aliases for GPKOW Gene

  • G-Patch Domain And KOW Motifs 2 3 5
  • Protein MOS2 Homolog 3 4
  • GPATCH5 3 4
  • GPATC5 3 4
  • T54 3 4
  • G Patch Domain And KOW Motifs-Containing Protein 3
  • G Patch Domain-Containing Protein 5 4
  • G Patch Domain Containing 5 2
  • Protein T54 4
  • Spp2 3

External Ids for GPKOW Gene

Previous GeneCards Identifiers for GPKOW Gene

  • GC0XM047997
  • GC0XM048726
  • GC0XM048857
  • GC0XM048970
  • GC0XM046625

Summaries for GPKOW Gene

Entrez Gene Summary for GPKOW Gene

  • This gene encodes a putative RNA-binding protein containing G-patch and KOW (Kyprides, Ouzounis, Woese) domains. The encoded protein interacts directly with protein kinase A and protein kinase X and is also found associated with the spliceosome. [provided by RefSeq, Aug 2013]

GeneCards Summary for GPKOW Gene

GPKOW (G-Patch Domain And KOW Motifs) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleic acid binding.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPKOW Gene

Genomics for GPKOW Gene

Regulatory Elements for GPKOW Gene

Enhancers for GPKOW Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around GPKOW on UCSC Golden Path with GeneCards custom track

Promoters for GPKOW Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPKOW on UCSC Golden Path with GeneCards custom track

Genomic Location for GPKOW Gene

Chromosome:
X
Start:
49,113,385 bp from pter
End:
49,123,801 bp from pter
Size:
10,417 bases
Orientation:
Minus strand

Genomic View for GPKOW Gene

Genes around GPKOW on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPKOW Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPKOW Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPKOW Gene

Proteins for GPKOW Gene

  • Protein details for GPKOW Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92917-GPKOW_HUMAN
    Recommended name:
    G patch domain and KOW motifs-containing protein
    Protein Accession:
    Q92917
    Secondary Accessions:
    • Q59EK5
    • Q9BQA8

    Protein attributes for GPKOW Gene

    Size:
    476 amino acids
    Molecular mass:
    52229 Da
    Quaternary structure:
    • Interacts with PRKX.
    SequenceCaution:
    • Sequence=AAB18640.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

neXtProt entry for GPKOW Gene

Post-translational modifications for GPKOW Gene

  • Ubiquitination at Lys 192, Lys 299, Lys 315, and Lys 372
  • Modification sites at PhosphoSitePlus

Other Protein References for GPKOW Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for GPKOW

No data available for DME Specific Peptides for GPKOW Gene

Domains & Families for GPKOW Gene

Gene Families for GPKOW Gene

Protein Domains for GPKOW Gene

Suggested Antigen Peptide Sequences for GPKOW Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92917

UniProtKB/Swiss-Prot:

GPKOW_HUMAN :
  • Contains 1 G-patch domain.
  • Belongs to the MOS2 family.
Domain:
  • Contains 1 G-patch domain.
  • Contains 2 KOW domains.
Family:
  • Belongs to the MOS2 family.
genes like me logo Genes that share domains with GPKOW: view

Function for GPKOW Gene

Gene Ontology (GO) - Molecular Function for GPKOW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 16491121
genes like me logo Genes that share ontologies with GPKOW: view
genes like me logo Genes that share phenotypes with GPKOW: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPKOW Gene

Localization for GPKOW Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPKOW Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPKOW Gene COMPARTMENTS Subcellular localization image for GPKOW gene
Compartment Confidence
nucleus 5
cytosol 3
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GPKOW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with GPKOW: view

Pathways & Interactions for GPKOW Gene

genes like me logo Genes that share pathways with GPKOW: view

Pathways by source for GPKOW Gene

Gene Ontology (GO) - Biological Process for GPKOW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with GPKOW: view

No data available for SIGNOR curated interactions for GPKOW Gene

Drugs & Compounds for GPKOW Gene

No Compound Related Data Available

Transcripts for GPKOW Gene

mRNA/cDNA for GPKOW Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(252) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPKOW Gene

G patch domain and KOW motifs:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPKOW Gene

No ASD Table

Relevant External Links for GPKOW Gene

GeneLoc Exon Structure for
GPKOW
ECgene alternative splicing isoforms for
GPKOW

Expression for GPKOW Gene

mRNA expression in normal human tissues for GPKOW Gene

Protein differential expression in normal tissues from HIPED for GPKOW Gene

This gene is overexpressed in Cervix (11.8), Peripheral blood mononuclear cells (9.5), and Lymph node (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GPKOW Gene



Protein tissue co-expression partners for GPKOW Gene

NURSA nuclear receptor signaling pathways regulating expression of GPKOW Gene:

GPKOW

SOURCE GeneReport for Unigene cluster for GPKOW Gene:

Hs.503666
genes like me logo Genes that share expression patterns with GPKOW: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GPKOW Gene

Orthologs for GPKOW Gene

This gene was present in the common ancestor of animals.

Orthologs for GPKOW Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPKOW 34
  • 87.09 (n)
  • 82.34 (a)
GPKOW 35
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPKOW 34
  • 86.62 (n)
  • 82.14 (a)
GPKOW 35
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpkow 34
  • 80.23 (n)
  • 76.87 (a)
Gpkow 16
Gpkow 35
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpkow 34
  • 80.59 (n)
  • 77.94 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 56 (a)
OneToMany
-- 35
  • 60 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia GPKOW 35
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPKOW 35
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11083 34
zebrafish
(Danio rerio)
Actinopterygii gpkow 34
  • 56.8 (n)
  • 50.22 (a)
mpzf637-1-001655 34
gpkow 35
  • 42 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10324 35
  • 19 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea R11A8.2 34
  • 41.14 (n)
  • 32.44 (a)
F53B2.1 35
  • 26 (a)
OneToMany
R11A8.2 35
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 32 (a)
OneToOne
Species where no ortholog for GPKOW was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPKOW Gene

ENSEMBL:
Gene Tree for GPKOW (if available)
TreeFam:
Gene Tree for GPKOW (if available)

Paralogs for GPKOW Gene

No data available for Paralogs for GPKOW Gene

Variants for GPKOW Gene

Sequence variations from dbSNP and Humsavar for GPKOW Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs4824460 -- 49,125,280(+) gaaaa(A/C)caaaa upstream-variant-2KB
rs5906740 -- 49,118,263(+) tatta(A/G)gactg intron-variant
rs5953264 -- 49,121,384(+) gatca(C/T)accac intron-variant
rs6608843 -- 49,125,506(+) ctcca(C/T)taaaa upstream-variant-2KB
rs6609834 -- 49,114,920(+) tctgt(C/T)tcaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPKOW Gene

Variant ID Type Subtype PubMed ID
esv1526582 CNV insertion 17803354
esv32909 CNV gain+loss 17666407
nsv204 OTHER inversion 15895083
nsv528292 CNV gain 19592680
nsv7442 OTHER inversion 18451855

Variation tolerance for GPKOW Gene

Residual Variation Intolerance Score: 78.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.07; 21.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPKOW Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPKOW

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPKOW Gene

Disorders for GPKOW Gene

Relevant External Links for GPKOW

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPKOW

No disorders were found for GPKOW Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPKOW Gene

Publications for GPKOW Gene

  1. Dynamic protein-protein interaction wiring of the human spliceosome. (PMID: 22365833) Hegele A. … Stelzl U. (Mol. Cell 2012) 2 3 65
  2. G-patch domain and KOW motifs-containing protein, GPKOW; a nuclear RNA-binding protein regulated by protein kinase A. (PMID: 21880142) Aksaas A.K. … SkAYlhegg B.S. (J Mol Signal 2011) 2 3 65
  3. Smad6 is a protein kinase X phosphorylation substrate and is required for HL-60 cell differentiation. (PMID: 16491121) Glesne D. … Huberman E. (Oncogene 2006) 3 4 65
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65

Products for GPKOW Gene

Sources for GPKOW Gene

Content