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Aliases for GPKOW Gene

Aliases for GPKOW Gene

  • G-Patch Domain And KOW Motifs 2 3 5
  • Protein MOS2 Homolog 3 4
  • GPATCH5 3 4
  • GPATC5 3 4
  • T54 3 4
  • G Patch Domain And KOW Motifs-Containing Protein 3
  • G-Patch Domain And KOW Motifs-Containing Protein 3
  • G-Patch Domain-Containing Protein 5 4
  • G Patch Domain Containing 5 2
  • Protein T54 4
  • Spp2 3

External Ids for GPKOW Gene

Previous GeneCards Identifiers for GPKOW Gene

  • GC0XM047997
  • GC0XM048726
  • GC0XM048857
  • GC0XM048970
  • GC0XM046625

Summaries for GPKOW Gene

Entrez Gene Summary for GPKOW Gene

  • This gene encodes a putative RNA-binding protein containing G-patch and KOW (Kyprides, Ouzounis, Woese) domains. The encoded protein interacts directly with protein kinase A and protein kinase X and is also found associated with the spliceosome. [provided by RefSeq, Aug 2013]

GeneCards Summary for GPKOW Gene

GPKOW (G-Patch Domain And KOW Motifs) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.

Additional gene information for GPKOW Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPKOW Gene

Genomics for GPKOW Gene

GeneHancer (GH) Regulatory Elements for GPKOW Gene

Promoters and enhancers for GPKOW Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI049122 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.2 237 2 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 IRF4 YY1 E2F8 GPKOW PLP2 WDR45
GH0XI048954 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 12.4 +165.0 165033 8.1 HDGF PKNOX1 CLOCK SMAD1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 IRF4 OTUD5 RNU6-722P GPKOW PIM2 SLC35A2 PCSK1N ENSG00000228343 KCND1 GRIPAP1
GH0XI049146 Enhancer 1.3 Ensembl ENCODE dbSUPER 18.6 -24.4 -24437 2.7 HDGF PKNOX1 ATF1 ARNT NCOA2 TCF12 GATA2 ATF7 NCOA1 ZNF592 GPKOW PLP2 RN7SL262P PIR61093 LOC105373195
GH0XI049176 Enhancer 1.1 Ensembl ENCODE dbSUPER 12 -53.3 -53262 1.9 CTCF KLF1 KLF17 MAX CDC5L ZIC2 RAD21 POLR2B POLR2A SMC3 GPKOW PLP2 PRICKLE3
GH0XI049071 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 5.9 +50.4 50449 3.7 PKNOX1 SIN3A YY1 ETS1 GLIS2 ZNF143 KLF7 RUNX3 SP3 YY2 PRAF2 CCDC120 GPKOW TFE3 GC0XP049093 WDR45
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GPKOW on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPKOW gene promoter:

Genomic Locations for GPKOW Gene

Genomic Locations for GPKOW Gene
chrX:49,113,385-49,123,801
(GRCh38/hg38)
Size:
10,417 bases
Orientation:
Minus strand
chrX:48,969,022-48,980,151
(GRCh37/hg19)

Genomic View for GPKOW Gene

Genes around GPKOW on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPKOW Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPKOW Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPKOW Gene

Proteins for GPKOW Gene

  • Protein details for GPKOW Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92917-GPKOW_HUMAN
    Recommended name:
    G-patch domain and KOW motifs-containing protein
    Protein Accession:
    Q92917
    Secondary Accessions:
    • Q59EK5
    • Q9BQA8

    Protein attributes for GPKOW Gene

    Size:
    476 amino acids
    Molecular mass:
    52229 Da
    Quaternary structure:
    • Interacts with PRKX.
    SequenceCaution:
    • Sequence=AAB18640.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

neXtProt entry for GPKOW Gene

Post-translational modifications for GPKOW Gene

  • Ubiquitination at isoforms=192, isoforms=299, posLast=315315, and isoforms=372

Other Protein References for GPKOW Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPKOW Gene

Domains & Families for GPKOW Gene

Protein Domains for GPKOW Gene

Suggested Antigen Peptide Sequences for GPKOW Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92917

UniProtKB/Swiss-Prot:

GPKOW_HUMAN :
  • Belongs to the MOS2 family.
Family:
  • Belongs to the MOS2 family.
genes like me logo Genes that share domains with GPKOW: view

Function for GPKOW Gene

Gene Ontology (GO) - Molecular Function for GPKOW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IMP 25296192
GO:0005515 protein binding IPI 16491121
genes like me logo Genes that share ontologies with GPKOW: view
genes like me logo Genes that share phenotypes with GPKOW: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPKOW Gene

Localization for GPKOW Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPKOW Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPKOW gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GPKOW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 21880142
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IDA 25296192
genes like me logo Genes that share ontologies with GPKOW: view

Pathways & Interactions for GPKOW Gene

genes like me logo Genes that share pathways with GPKOW: view

Pathways by source for GPKOW Gene

Gene Ontology (GO) - Biological Process for GPKOW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with GPKOW: view

No data available for SIGNOR curated interactions for GPKOW Gene

Drugs & Compounds for GPKOW Gene

No Compound Related Data Available

Transcripts for GPKOW Gene

mRNA/cDNA for GPKOW Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(252) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPKOW Gene

G patch domain and KOW motifs:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPKOW Gene

No ASD Table

Relevant External Links for GPKOW Gene

GeneLoc Exon Structure for
GPKOW
ECgene alternative splicing isoforms for
GPKOW

Expression for GPKOW Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPKOW Gene

Protein differential expression in normal tissues from HIPED for GPKOW Gene

This gene is overexpressed in Cervix (11.8), Peripheral blood mononuclear cells (9.5), and Lymph node (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GPKOW Gene



Protein tissue co-expression partners for GPKOW Gene

NURSA nuclear receptor signaling pathways regulating expression of GPKOW Gene:

GPKOW

SOURCE GeneReport for Unigene cluster for GPKOW Gene:

Hs.503666

Evidence on tissue expression from TISSUES for GPKOW Gene

  • Nervous system(4.4)
  • Lung(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with GPKOW: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPKOW Gene

Orthologs for GPKOW Gene

This gene was present in the common ancestor of animals.

Orthologs for GPKOW Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPKOW 33 34
  • 87.09 (n)
dog
(Canis familiaris)
Mammalia GPKOW 33 34
  • 86.62 (n)
rat
(Rattus norvegicus)
Mammalia Gpkow 33
  • 80.59 (n)
mouse
(Mus musculus)
Mammalia Gpkow 33 16 34
  • 80.23 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 60 (a)
OneToMany
-- 34
  • 56 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia GPKOW 34
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPKOW 34
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11083 33
zebrafish
(Danio rerio)
Actinopterygii gpkow 33 34
  • 56.8 (n)
mpzf637-1-001655 33
fruit fly
(Drosophila melanogaster)
Insecta CG10324 34
  • 19 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea R11A8.2 33 34
  • 41.14 (n)
F53B2.1 34
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 32 (a)
OneToOne
Species where no ortholog for GPKOW was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPKOW Gene

ENSEMBL:
Gene Tree for GPKOW (if available)
TreeFam:
Gene Tree for GPKOW (if available)

Paralogs for GPKOW Gene

No data available for Paralogs for GPKOW Gene

Variants for GPKOW Gene

Sequence variations from dbSNP and Humsavar for GPKOW Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000175311 -- 49,124,527(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000227699 -- 49,125,024(-) C/G upstream_transcript_variant
rs1001347209 -- 49,117,943(-) G/A intron_variant
rs1001796924 -- 49,118,441(-) T/G intron_variant
rs1002293475 -- 49,119,600(-) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GPKOW Gene

Variant ID Type Subtype PubMed ID
esv1526582 CNV insertion 17803354
esv32909 CNV gain+loss 17666407
nsv204 OTHER inversion 15895083
nsv528292 CNV gain 19592680
nsv7442 OTHER inversion 18451855

Variation tolerance for GPKOW Gene

Residual Variation Intolerance Score: 78.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.07; 21.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPKOW Gene

Human Gene Mutation Database (HGMD)
GPKOW
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPKOW

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPKOW Gene

Disorders for GPKOW Gene

Additional Disease Information for GPKOW

No disorders were found for GPKOW Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPKOW Gene

Publications for GPKOW Gene

  1. Dynamic protein-protein interaction wiring of the human spliceosome. (PMID: 22365833) Hegele A … Stelzl U (Molecular cell 2012) 2 3 58
  2. G-patch domain and KOW motifs-containing protein, GPKOW; a nuclear RNA-binding protein regulated by protein kinase A. (PMID: 21880142) Aksaas AK … Skålhegg BS (Journal of molecular signaling 2011) 2 3 58
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  4. Smad6 is a protein kinase X phosphorylation substrate and is required for HL-60 cell differentiation. (PMID: 16491121) Glesne D … Huberman E (Oncogene 2006) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for GPKOW Gene

Sources for GPKOW Gene

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