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Aliases for GPKOW Gene

Aliases for GPKOW Gene

  • G-Patch Domain And KOW Motifs 2 3 5
  • Protein MOS2 Homolog 3 4
  • GPATCH5 3 4
  • GPATC5 3 4
  • T54 3 4
  • G Patch Domain And KOW Motifs-Containing Protein 3
  • G Patch Domain-Containing Protein 5 4
  • G Patch Domain Containing 5 2
  • Protein T54 4
  • Spp2 3

External Ids for GPKOW Gene

Previous GeneCards Identifiers for GPKOW Gene

  • GC0XM047997
  • GC0XM048726
  • GC0XM048857
  • GC0XM048970
  • GC0XM046625

Summaries for GPKOW Gene

Entrez Gene Summary for GPKOW Gene

  • This gene encodes a putative RNA-binding protein containing G-patch and KOW (Kyprides, Ouzounis, Woese) domains. The encoded protein interacts directly with protein kinase A and protein kinase X and is also found associated with the spliceosome. [provided by RefSeq, Aug 2013]

GeneCards Summary for GPKOW Gene

GPKOW (G-Patch Domain And KOW Motifs) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include nucleic acid binding.

Additional gene information for GPKOW Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPKOW Gene

Genomics for GPKOW Gene

Regulatory Elements for GPKOW Gene

Enhancers for GPKOW Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH049146 1.4 Ensembl ENCODE dbSUPER 18.6 -24.4 -24438 2.7 HDAC1 ELF3 TBP HDGF PKNOX1 ATF1 RB1 TBL1XR1 ARNT NFRKB GPKOW PLP2 RN7SL262P PIR61093
GH0XH048954 1.6 Ensembl ENCODE dbSUPER 12.4 +165.0 165033 8.1 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF143 FOS GPKOW PIM2 SLC35A2 PCSK1N ENSG00000228343 KCND1 GRIPAP1 OTUD5 RNU6-722P
GH0XH049176 1.3 Ensembl ENCODE dbSUPER 12 -53.3 -53262 1.9 CTCF KLF1 KLF17 MAX CDC5L ZIC2 RAD21 POLR2A SMC3 KLF7 GPKOW PLP2 PRICKLE3
GH0XH049154 1.8 FANTOM5 Ensembl ENCODE dbSUPER 5.9 -32.1 -32080 2.6 HDGF PKNOX1 ATF1 SIN3A ZNF766 GLIS2 ZNF143 FOS KLF7 ATF7 ENSG00000270012 FTSJ1 GPKOW HDAC6 MAGIX GATA1 LOC105373195 RN7SL262P
GH0XH049029 0.7 ENCODE dbSUPER 13.1 +93.7 93670 1.5 KLF1 POLR2A GPKOW WDR45 TFE3 GC0XM049007
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPKOW on UCSC Golden Path with GeneCards custom track

Promoters for GPKOW Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000246553 201 1600 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 ZNF143 SP3

Genomic Locations for GPKOW Gene

Genomic Locations for GPKOW Gene
10,417 bases
Minus strand

Genomic View for GPKOW Gene

Genes around GPKOW on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPKOW Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPKOW Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPKOW Gene

Proteins for GPKOW Gene

  • Protein details for GPKOW Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G patch domain and KOW motifs-containing protein
    Protein Accession:
    Secondary Accessions:
    • Q59EK5
    • Q9BQA8

    Protein attributes for GPKOW Gene

    476 amino acids
    Molecular mass:
    52229 Da
    Quaternary structure:
    • Interacts with PRKX.
    • Sequence=AAB18640.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

neXtProt entry for GPKOW Gene

Post-translational modifications for GPKOW Gene

  • Ubiquitination at posLast=192192, isoforms=299, posLast=315315, and isoforms=372
  • Modification sites at PhosphoSitePlus

Other Protein References for GPKOW Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPKOW Gene

Domains & Families for GPKOW Gene

Gene Families for GPKOW Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GPKOW Gene

Suggested Antigen Peptide Sequences for GPKOW Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MOS2 family.
  • Belongs to the MOS2 family.
genes like me logo Genes that share domains with GPKOW: view

Function for GPKOW Gene

Gene Ontology (GO) - Molecular Function for GPKOW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 16491121
genes like me logo Genes that share ontologies with GPKOW: view
genes like me logo Genes that share phenotypes with GPKOW: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPKOW Gene

Localization for GPKOW Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPKOW Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPKOW gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GPKOW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with GPKOW: view

Pathways & Interactions for GPKOW Gene

genes like me logo Genes that share pathways with GPKOW: view

Pathways by source for GPKOW Gene

Gene Ontology (GO) - Biological Process for GPKOW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with GPKOW: view

No data available for SIGNOR curated interactions for GPKOW Gene

Drugs & Compounds for GPKOW Gene

No Compound Related Data Available

Transcripts for GPKOW Gene

mRNA/cDNA for GPKOW Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(252) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPKOW Gene

G patch domain and KOW motifs:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPKOW Gene

No ASD Table

Relevant External Links for GPKOW Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPKOW Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPKOW Gene

Protein differential expression in normal tissues from HIPED for GPKOW Gene

This gene is overexpressed in Cervix (11.8), Peripheral blood mononuclear cells (9.5), and Lymph node (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GPKOW Gene

Protein tissue co-expression partners for GPKOW Gene

NURSA nuclear receptor signaling pathways regulating expression of GPKOW Gene:


SOURCE GeneReport for Unigene cluster for GPKOW Gene:


Evidence on tissue expression from TISSUES for GPKOW Gene

  • Nervous system(4.4)
  • Lung(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with GPKOW: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPKOW Gene

Orthologs for GPKOW Gene

This gene was present in the common ancestor of animals.

Orthologs for GPKOW Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPKOW 33 34
  • 87.09 (n)
(Canis familiaris)
Mammalia GPKOW 33 34
  • 86.62 (n)
(Rattus norvegicus)
Mammalia Gpkow 33
  • 80.59 (n)
(Mus musculus)
Mammalia Gpkow 33 16 34
  • 80.23 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 60 (a)
-- 34
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia GPKOW 34
  • 45 (a)
(Anolis carolinensis)
Reptilia GPKOW 34
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11083 33
(Danio rerio)
Actinopterygii gpkow 33 34
  • 56.8 (n)
mpzf637-1-001655 33
fruit fly
(Drosophila melanogaster)
Insecta CG10324 34
  • 19 (a)
(Caenorhabditis elegans)
Secernentea R11A8.2 33 34
  • 41.14 (n)
F53B2.1 34
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 32 (a)
Species where no ortholog for GPKOW was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPKOW Gene

Gene Tree for GPKOW (if available)
Gene Tree for GPKOW (if available)

Paralogs for GPKOW Gene

No data available for Paralogs for GPKOW Gene

Variants for GPKOW Gene

Sequence variations from dbSNP and Humsavar for GPKOW Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000175311 -- 49,124,527(+) CCAGC(C/T)TGGGT upstream-variant-2KB, utr-variant-5-prime
rs1000227699 -- 49,125,024(+) CAGCA(C/G)TTTAG upstream-variant-2KB
rs1000735674 -- 49,115,389(+) GTAAT(A/C/G)CCAGC intron-variant
rs1001347209 -- 49,117,943(+) GAGAT(A/G)GAGTT intron-variant
rs1001796924 -- 49,118,441(+) CGGAT(G/T)ATAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPKOW Gene

Variant ID Type Subtype PubMed ID
nsv7442 OTHER inversion 18451855
nsv528292 CNV gain 19592680
nsv204 OTHER inversion 15895083
esv32909 CNV gain+loss 17666407
esv1526582 CNV insertion 17803354

Variation tolerance for GPKOW Gene

Residual Variation Intolerance Score: 78.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.07; 21.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPKOW Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPKOW Gene

Disorders for GPKOW Gene

Relevant External Links for GPKOW

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GPKOW Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPKOW Gene

Publications for GPKOW Gene

  1. Dynamic protein-protein interaction wiring of the human spliceosome. (PMID: 22365833) Hegele A … Stelzl U (Molecular cell 2012) 2 3 60
  2. G-patch domain and KOW motifs-containing protein, GPKOW; a nuclear RNA-binding protein regulated by protein kinase A. (PMID: 21880142) Aksaas AK … Skålhegg BS (Journal of molecular signaling 2011) 2 3 60
  3. Smad6 is a protein kinase X phosphorylation substrate and is required for HL-60 cell differentiation. (PMID: 16491121) Glesne D … Huberman E (Oncogene 2006) 3 4 60
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for GPKOW Gene

Sources for GPKOW Gene

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