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Aliases for GPKOW Gene

Aliases for GPKOW Gene

  • G Patch Domain And KOW Motifs 2 3
  • Protein MOS2 Homolog 3 4
  • GPATCH5 3 4
  • GPATC5 3 4
  • T54 3 4
  • G Patch Domain And KOW Motifs-Containing Protein 3
  • G Patch Domain-Containing Protein 5 4
  • G Patch Domain Containing 5 2
  • Protein T54 4
  • SPP2 3

External Ids for GPKOW Gene

Previous GeneCards Identifiers for GPKOW Gene

  • GC0XM047997
  • GC0XM048726
  • GC0XM048857
  • GC0XM048970
  • GC0XM046625

Summaries for GPKOW Gene

Entrez Gene Summary for GPKOW Gene

  • This gene encodes a putative RNA-binding protein containing G-patch and KOW (Kyprides, Ouzounis, Woese) domains. The encoded protein interacts directly with protein kinase A and protein kinase X and is also found associated with the spliceosome. [provided by RefSeq, Aug 2013]

GeneCards Summary for GPKOW Gene

GPKOW (G Patch Domain And KOW Motifs) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPKOW Gene

Genomics for GPKOW Gene

Regulatory Elements for GPKOW Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GPKOW Gene

49,113,385 bp from pter
49,123,801 bp from pter
10,417 bases
Minus strand

Genomic View for GPKOW Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPKOW Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPKOW Gene

Proteins for GPKOW Gene

  • Protein details for GPKOW Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G patch domain and KOW motifs-containing protein
    Protein Accession:
    Secondary Accessions:
    • Q59EK5
    • Q9BQA8

    Protein attributes for GPKOW Gene

    476 amino acids
    Molecular mass:
    52229 Da
    Quaternary structure:
    • Interacts with PRKX.
    • Sequence=AAB18640.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

neXtProt entry for GPKOW Gene

Proteomics data for GPKOW Gene at MOPED

Post-translational modifications for GPKOW Gene

  • Ubiquitination at Lys192, Lys299, Lys315, and Lys372
  • Modification sites at PhosphoSitePlus

Other Protein References for GPKOW Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GPKOW Gene

Domains for GPKOW Gene

Gene Families for GPKOW Gene

  • GPATCH :G patch domain containing

Protein Domains for GPKOW Gene

Suggested Antigen Peptide Sequences for GPKOW Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q92917
  • Contains 1 G-patch domain.
  • Contains 2 KOW domains.
  • Belongs to the MOS2 family.
genes like me logo Genes that share domains with GPKOW: view

Function for GPKOW Gene

Gene Ontology (GO) - Molecular Function for GPKOW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 16491121
genes like me logo Genes that share ontologies with GPKOW: view
genes like me logo Genes that share phenotypes with GPKOW: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPKOW

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GPKOW Gene

Localization for GPKOW Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPKOW Gene

Subcellular locations from

Jensen Localization Image for GPKOW Gene COMPARTMENTS Subcellular localization image for GPKOW gene
Compartment Confidence
nucleus 4
cytosol 3
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GPKOW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with GPKOW: view

Pathways for GPKOW Gene

SuperPathways for GPKOW Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPKOW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with GPKOW: view

No data available for Pathways by source for GPKOW Gene

Transcripts for GPKOW Gene

mRNA/cDNA for GPKOW Gene

(252) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPKOW Gene

G patch domain and KOW motifs:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPKOW

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPKOW Gene

No ASD Table

Relevant External Links for GPKOW Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPKOW Gene

mRNA expression in normal human tissues for GPKOW Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for GPKOW Gene

This gene is overexpressed in Cervix (11.8), Peripheral blood mononuclear cells (9.5), and Lymph node (7.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GPKOW Gene

SOURCE GeneReport for Unigene cluster for GPKOW Gene Hs.503666

genes like me logo Genes that share expressions with GPKOW: view

Expression partners for GPKOW Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GPKOW Gene

Orthologs for GPKOW Gene

This gene was present in the common ancestor of animals.

Orthologs for GPKOW Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPKOW 35
  • 87.09 (n)
  • 82.34 (a)
  • 80 (a)
(Canis familiaris)
Mammalia GPKOW 35
  • 86.62 (n)
  • 82.14 (a)
  • 81 (a)
(Mus musculus)
Mammalia Gpkow 35
  • 80.23 (n)
  • 76.87 (a)
Gpkow 16
Gpkow 36
  • 73 (a)
(Rattus norvegicus)
Mammalia Gpkow 35
  • 80.59 (n)
  • 77.94 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 56 (a)
-- 36
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia GPKOW 36
  • 45 (a)
(Anolis carolinensis)
Reptilia GPKOW 36
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11083 35
(Danio rerio)
Actinopterygii gpkow 35
  • 56.8 (n)
  • 50.22 (a)
mpzf637-1-001655 35
gpkow 36
  • 42 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10324 36
  • 19 (a)
(Caenorhabditis elegans)
Secernentea R11A8.2 35
  • 41.14 (n)
  • 32.44 (a)
F53B2.1 36
  • 26 (a)
R11A8.2 36
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
Species with no ortholog for GPKOW:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPKOW Gene

Gene Tree for GPKOW (if available)
Gene Tree for GPKOW (if available)

Paralogs for GPKOW Gene

No data available for Paralogs for GPKOW Gene

Variants for GPKOW Gene

Sequence variations from dbSNP and Humsavar for GPKOW Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs4824460 -- 49,125,280(+) gaaaa(A/C)caaaa upstream-variant-2KB
rs5906740 -- 49,118,263(+) tatta(A/G)gactg intron-variant
rs5953264 -- 49,121,384(+) gatca(C/T)accac intron-variant
rs6608843 -- 49,125,506(+) ctcca(C/T)taaaa upstream-variant-2KB
rs6609834 -- 49,114,920(+) tctgt(C/T)tcaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPKOW Gene

Variant ID Type Subtype PubMed ID
esv32909 CNV Gain+Loss 17666407
nsv528292 CNV Gain 19592680
esv1526582 CNV Insertion 17803354
nsv7442 OTHER Inversion 18451855
nsv204 OTHER Inversion 15895083

Relevant External Links for GPKOW Gene

HapMap Linkage Disequilibrium report
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPKOW Gene

Disorders for GPKOW Gene

No disorders were found for GPKOW Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for GPKOW Gene

Publications for GPKOW Gene

  1. Dynamic protein-protein interaction wiring of the human spliceosome. (PMID: 22365833) Hegele A. … Stelzl U. (Mol. Cell 2012) 2 3
  2. Smad6 is a protein kinase X phosphorylation substrate and is required for HL-60 cell differentiation. (PMID: 16491121) Glesne D. … Huberman E. (Oncogene 2006) 3 4
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  4. Long-range map of a 3.5-Mb region in Xp11.23-22 with a sequence-ready map from a 1.1-Mb gene-rich interval. (PMID: 8938429) Schindelhauer D. … Meindl A. (Genome Res. 1996) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for GPKOW Gene

Sources for GPKOW Gene

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