Aliases for GPIHBP1 Gene
External Ids for GPIHBP1 Gene
Previous GeneCards Identifiers for GPIHBP1 Gene
This gene encodes a capillary endothelial cell protein that facilitates the lipolytic processing of triglyceride-rich lipoproteins. The encoded protein is a glycosylphosphatidylinositol-anchored protein that is a member of the lymphocyte antigen 6 (Ly6) family. This protein plays a major role in transporting lipoprotein lipase (LPL) from the subendothelial spaces to the capillary lumen. Mutations in this gene are the cause of hyperlipoproteinemia, type 1D. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
GeneCards Summary for GPIHBP1 Gene
GPIHBP1 (Glycosylphosphatidylinositol Anchored High Density Lipoprotein Binding Protein 1) is a Protein Coding gene. Diseases associated with GPIHBP1 include hyperlipoproteinemia, type 1d and familial lipoprotein lipase deficiency. Among its related pathways are C-MYC pathway and Regulation of Wnt-mediated beta catenin signaling and target gene transcription. GO annotations related to this gene include lipid binding and protein transmembrane transporter activity.
UniProtKB/Swiss-Prot for GPIHBP1 Gene
Plays a key role in the lipolytic processing of chylomicrons. Required for the transport of lipoprotein lipase LPL into the capillary lumen (By similarity).