GPI Gene
protein-coding GIFtS: 70
GCID: GC19P034855
|
|
glucose-6-phosphate isomerase(Previous name: glucose phosphate isomerase )
| |
Aliases
for GPI gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Glucose-6-Phosphate Isomerase1 2 | | EC 5.3.1.93 8 | | AMF1 2 3 | | GNPI2 | | NLK1 2 3 | | SA362 | | Glucose Phosphate Isomerase1 2 | | Hexose Monophosphate Isomerase2 | | Autocrine Motility Factor2 3 | | Hexosephosphate Isomerase2 | | Phosphoglucose Isomerase2 3 | | Neuroleukin3 | | Phosphohexose Isomerase2 3 | | Oxoisomerase1 | | Sperm Antigen 362 3 | | Phosphohexomutase1 | | PGI2 3 | | Phosphosaccharomutase1 | | PHI2 3 | | Sperm Antigen-362 | | SA-362 3 | | Neuroleukin3 |
Export aliases for GPI gene to outside databasesPrevious GC identifers: GC19P035473 GC19P035305 GC19P039531 GC19P039547 GC19P031360 |
Summaries
for GPI gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GPI:
This gene belongs to the GPI family whose members encode multifunctional phosphoglucose isomerase proteins involved inenergy pathways. The protein encoded by this gene is a dimeric enzyme that catalyzes the reversible isomerization ofglucose-6-phosphate and fructose-6-phosphate. The protein functions in different capacities inside and outside thecell. In the cytoplasm, the gene product is involved in glycolysis and gluconeogenesis, while outside the cell itfunctions as a neurotrophic factor for spinal and sensory neurons. Defects in this gene are the cause ofnonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediateneonatal death and neurological impairment. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: G6PI_HUMAN, P06744Function: Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and anangiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) forspinal and sensory neurons
Gene Wiki entry for GPI (Glucose-6-phosphate isomerase)
|
Genomic Views
for GPI gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GPI gene promoter:
GR AP-2alpha isoform 3 AP-1 ATF-2 AP-2alpha isoform 2 CRE-BP1 c-Jun GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for GPI
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPI |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.1 Ensembl cytogenetic band: 19q13.11 HGNC cytogenetic band: 19q13.1GPI Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P034855: view genomic region
(about GC identifiers)
Start:
|
34,850,385 bp from pter |
End:
|
34,893,318 bp from pter |
Size:
|
42,934 bases |
Orientation:
|
plus strand |
|
Proteins
for GPI gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: G6PI_HUMAN, P06744 (See
protein sequence)Recommended Name: Glucose-6-phosphate isomerase Size: 558 amino acids; 63147 Da
Subunit: Homodimer in the catalytically active form, monomer in the secreted form
Subcellular location: Cytoplasm. Secreted
5 PDB 3D structures from  and Proteopedia  for GPI:1IAT (3D)
1IRI (3D)
1JIQ (3D)
1JLH (3D)
1NUH (3D)
Secondary accessions: B4DG39 Q9BRD3 Q9BSK5 Q9UHE6Alternative splicing: 2 isoforms: P06744-1 P06744-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for GPI: NX_P06744
Post-translational modifications:
Phosphorylation at Ser-185 by CK2 has been shown to decrease enzymatic activity and may contribute to secretion by anon-classical secretory pathway1
ISGylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P06744
4/47 DME Specific Peptides for GPI (P06744) (see all 47)
GPI Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_000166.2 NP_001171651.1
ENSEMBL proteins: ENSP00000464797 ENSP00000468298 ENSP00000466191 ENSP00000405573 ENSP00000465858 ENSP00000464798 ENSP00000467221 ENSP00000348877 ENSP00000468201 ENSP00000467590 ENSP00000466851 ENSP00000467670 ENSP00000467062 Reactome Protein details: P06744
Human Recombinant Protein Products for GPI:
Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table
GPI for ontologies About GeneDecksing
GPI Antibody Products:
Assay Products for GPI: |
Protein
Domains /
Families
for GPI gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GPI for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P06744ProtoNet protein and cluster: P06744 1 Blocks protein family: IPB001672 Phosphoglucose isomerase (PGI)
UniProtKB/Swiss-Prot: G6PI_HUMAN, P06744Similarity: Belongs to the GPI family |
Function
for GPI gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: G6PI_HUMAN, P06744Function: Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and anangiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) forspinal and sensory neuronsCatalytic activity: D-glucose 6-phosphate = D-fructose 6-phosphate Genatlas biochemistry entry for GPI:glucose phosphate isomerase (neuroleukin),glycolysis,gluconeogenesis,energy pathways
Enzyme Number (IUBMB): EC 5.3.1.91 2
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004347 | glucose-6-phosphate isomerase activity |
TAS | -- | | GO:0005125 | cytokine activity |
IEA | -- | | GO:0008083 | growth factor activity |
IEA | -- | | GO:0016866 | intramolecular transferase activity |
IEA | -- | | GO:0048029 | monosaccharide binding |
IEA | -- |
GPI for ontologies About GeneDecksing
Phenotypes:
10 MGI mutant phenotypes (inferred from 11 alleles ) (MGI details for Gpi1):
GPI for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPI (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPI (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): GPI (NM_000175) | |  | Sino Biological Human cDNA Clone for GPI | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GPI | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPI |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPI |
|
Pathways & Interactions
for GPI gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Glycolysis and gluconeogenesis (short map) | | | 2 | Glucose metabolism | | | 3 | Metabolism | | | 4 | Galactose metabolism | | | 5 | Pentose Phosphate Pathway (Erythrocyte) | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for GPI
2  GeneGo (Thomson Reuters) Pathways for GPI
1  BioSystems Pathway for GPI
5 
Reactome Pathways for GPI
1  PharmGKB Pathway for GPI
5 
Kegg Pathways (Kegg details for GPI):
UniProtKB/Swiss-Prot: G6PI_HUMAN, P06744Pathway: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose:step 2/4
GPI for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GPI
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/114 Interacting proteins for GPI (P067443 ENSP000003488774) via UniProtKB, MINT, STRING, and/or I2D (see all 114)
About this table
Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table
GPI for ontologies About GeneDecksing
|
Drugs & Compounds
for GPI gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
GPI for compounds About GeneDecksing
 Browse Tocris compounds for GPI
5 HMDB Compounds for GPI About this table
8 DrugBank Compounds for GPI About this table
10/43 Novoseek chemical compound relationships for GPI gene (see all 43) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| glucose 6-phosphate |
89.2 |
197 |
8381960 (5), 15206941 (3), 10916680 (3), 15290745 (2) (see all 96) |
| 6-phosphogluconate |
75.8 |
12 |
9041338 (1), 1471744 (1), 18817779 (1), 7737089 (1) (see all 9) |
| fructose-6-phosphate |
74.6 |
21 |
8381960 (3), 15103138 (1), 10916680 (1), 14586688 (1) (see all 11) |
| malate |
54.9 |
14 |
9041338 (1), 9921283 (1), 1471744 (1), 15691124 (1) (see all 9) |
| erythrose 4-phosphate |
54.1 |
3 |
12374700 (1), 15850830 (1) |
| glucosamine 6-phosphate |
44 |
1 |
9864853 (1) |
| pyruvate |
37.1 |
12 |
9362562 (2), 8283448 (1), 1967237 (1), 1846809 (1) (see all 9) |
| cellulose acetate |
34.2 |
1 |
12378792 (1) |
| glyceraldehyde 3-phosphate |
34 |
8 |
1834654 (2), 15752986 (1), 1471744 (1), 17464938 (1) (see all 6) |
| lactate |
25.5 |
15 |
1834654 (2), 8283448 (1), 7885731 (1), 15752986 (1) (see all 11) |
Search CenterWatch for drugs/clinical trials and news about GPI / G6PI
|
Transcripts
for GPI gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GPI gene (2 alternative transcripts): NM_000175.3 NM_001184722.1 Unigene Cluster for GPI: Glucose-6-phosphate isomerase Hs.466471 [show with all ESTs]Unigene Representative Sequence: NM_00118472217 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000587521 ENST00000587384 ENST00000592277 ENST00000415930(uc010xrv.2 uc002nvf.3)
ENST00000588991 ENST00000592144 ENST00000589504 ENST00000590375 ENST00000356487(uc002nvg.2 uc010xrw.2 uc002nvh.1 uc002nvi.2)
ENST00000589399 ENST00000589640 ENST00000591204 ENST00000586425 ENST00000590362
ENST00000589985 ENST00000586392 ENST00000586077
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPI (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPI (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): GPI (NM_000175) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GPI | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPI |
Additional cDNA sequence: AK129884.1 AK130102.1 AK293446.1 AK294396.1 AK301103.1 BC004982.1 K03515.1 X16539.1 24/68 DOTS entries (see all 68): DT.100674927 DT.91798987 DT.92389405 DT.100674924 DT.100864718 DT.100674908 DT.97851996 DT.100859652 DT.95346616 DT.100674934 DT.100674910 DT.100674906 DT.121476681 DT.92053999 DT.100674925 DT.40193020 DT.121476863 DT.97801200 DT.100048150 DT.101965639 DT.91689860 DT.121476520 DT.100674903 DT.121476499 24/1209 AceView cDNA sequences (see all 1209): BM834030 AU124847 BE747613 BQ053964 BP345684 BX096161 AI273433 BF725628 BP372483 BM761330 BQ054207 CF131726 BU175140 CR603540 BQ887448 AU141181 BU557142 AU160119 BG036512 BG286925 AW247930 CD048113 BQ941045 AW182264
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for GPI (see all 10) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · |
|---|
|
| SP1: | | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 16b | ^ | 17a | · | 17b | ^ | 18 | ^ | 19a | · | 19b |
|---|
|
| SP1: | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | |
ECgene alternative splicing isoforms for GPI
|
Expression
for GPI gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GPI expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See GPI Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GPI
SOURCE GeneReport for Unigene cluster: Hs.466471
SABiosciences Expression via Pathway-Focused PCR Arrays including GPI (see all 7):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GPI
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GPI | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPI | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPI | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPI |
Orthologs
for GPI gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for GPI gene from 11/43 species (see all 43) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Gpi11 , 5 |
glucose phosphate isomerase 11, 5 |
86.26(n)1
88.89(a)1 |
|
7 (19.46 cM)5
147511 NM_008155.31 NP_032181.21
342021225 |
chicken
(Gallus gallus) |
Aves |
GPI1 |
glucose-6-phosphate isomerase |
75.7(n)
82.55(a) |
|
415783 NM_001006128.1 NP_001006128.1 |
lizard
(Anolis carolinensis) |
Reptilia |
GPI6 |
-- |
78(a) |
1 ↔ 1 |
GL343773.1(142574-184524) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.51942 |
Xenopus laevis transcribed sequence with moderate similarity more |
78.12(n) |
|
CD100154.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
gpia2 |
glucose phosphate isomerase a |
78.41(n) |
|
246094 AJ306395.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Pgi1 , 3 |
gluconeogenesis phosphogluconate
dehydrogenase more3
Phosphoglucose isomerase1 |
68(a)3
67.4(n)1
69.05(a)1 |
|
44F63
358861 NM_078939.21 NP_523663.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
Y87G2A.83
gpi-11 |
glucose-6-phosphate isomerase3
Protein GPI-11 |
68(a)3
62.04(n)1
68.19(a)1 |
|
I(13584707-13589480)3
1732271 NM_001026666.31 NP_001021837.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
PGI1(YBR196C)4
PGI11 |
Glycolytic enzyme phosphoglucose isomerase, catalyzes more4
Pgi1p1 |
58.12(n)1
59.11(a)1 |
|
2(613900-612236)4
8524951, 4 NP_009755.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT5G427406PGI16 |
phosphoglucose isomerase 1 |
42(a)21(a) |
1 ↔ 1possible ortholog |
5(17135692-17140892) 4(12708752-12712825) |
rice
(Oryza sativa) |
Liliopsida |
D45218.12 |
-- |
74.57(n) |
|
D45218.1 |
ENSEMBL Gene Tree for GPI (if available)
TreeFam Gene Tree for GPI (if available) |
Paralogs
for GPI gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for GPI gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GPI (34850385 - 34893318 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for GPI
1 CNV: 61702
Human Gene Mutation Database (HGMD): GPI
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GPI |
|
Disorders
/ Diseases
for GPI gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GPI for disorders About GeneDecksing
OMIM gene information: 172400
OMIM disorders: 613470
UniProtKB/Swiss-Prot: G6PI_HUMAN, P06744
Defects in GPI are the cause of hemolytic anemia non-spherocytic due to glucose phosphate isomerase deficiency(HA-GPID) [MIM:613470]. It is a form of anemia in which there is no abnormal hemoglobin or spherocytosis. It is causedby glucose phosphate isomerase deficiency. Severe GPI deficiency can be associated with hydrops fetalis, immediateneonatal death and neurological impairment
20/70  diseases for GPI (see all 70): About MalaCardshemolytic anemia, nonspherocytic, due to glucose phosphate isomerase deficiency hydrops fetalis hemolytic anemia anemia
glucosephosphate isomerase deficiency congenital nonspherocytic hemolytic anemia chronic intestinal vascular insufficiency enamel erosion
dentine erosion root caries primary hyperoxaluria squamous cell carcinoma
rheumatoid arthritis oral squamous cell carcinoma acquired immunodeficiency syndrome cutaneous leishmaniasis
esophageal squamous cell carcinoma myoclonus leishmaniasis lupus erythematosus
4 diseases from the University of Copenhagen DISEASES database for GPI:Enamel erosion Primary hyperoxaluria Dentine erosion Gingivitis 10/40 Novoseek disease relationships for GPI gene (see all 40) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| hereditary nonspherocytic hemolytic anemia |
81 |
6 |
7927011 (2), 9446754 (1), 8218542 (1), 17041899 (1) |
| anemia hemolytic |
66.5 |
30 |
9362562 (3), 11371164 (2), 8417789 (2), 9856489 (2) (see all 15) |
| anemia hemolytic congenital |
62.5 |
4 |
8822954 (1), 12737943 (1), 9616041 (1) |
| arthritis |
59.6 |
43 |
15290745 (3), 15320914 (3), 18534002 (3), 12687536 (3) (see all 22) |
| rheumatoid arthritis |
57.6 |
36 |
11477412 (2), 20337045 (2), 19032829 (2), 12730513 (2) (see all 19) |
| metastasis |
53.7 |
46 |
19787266 (3), 15684571 (2), 16294294 (2), 2006007 (1) (see all 33) |
| enzyme deficiency |
49.5 |
3 |
10916680 (1), 7927011 (1) |
| tumors |
42.6 |
98 |
15684571 (5), 14566819 (4), 14968121 (4), 17828376 (3) (see all 49) |
| fibrosarcoma |
42.5 |
2 |
14566819 (1) |
| leishmaniasis cutaneous |
39.1 |
1 |
9574789 (1) |
Genatlas disease: GPI hemolytic anemia,hydrops fetalis
Genetic Association Database (GAD): GPI
Human Genome Epidemiology (HuGE) Navigator: GPI (10 documents)
Export disorders for GPI gene to outside databases
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Publications
for GPI gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for GPI gene, integrated from 9 sources (see all 313):
(articles sorted by number of sources associating them with GPI) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Glucosephosphate isomerase (GPI) deficiency mutations associated with hereditary nonspherocytic hemolytic anemia (HNSHA). (PubMed id 9446754)1, 2, 4, 9 Beutler E.... Forman L. (1997)
- Characterization of the 5' end of the gene for human glucose phosphate isomerase (GPI). (PubMed id 2387591)1, 2, 3, 9 Walker J.I.H.... Morgan M.J. (1990)
- Molecular basis of neurological dysfunction coupled with haemolytic anaemia in human glucose-6-phosphate isomerase (GPI) deficiency. (PubMed id 9856489)1, 2, 9 Kugler W.... Lakomek M. (1998)
- Cloning of a glucose phosphate isomerase/neuroleukin-like sperm antigen involved in sperm agglutination. (PubMed id 10727272)1, 2, 9 Yakirevich E. and Naot Y. (2000)
- Differential regulation of phosphoglucose isomerase/autocrine motility factor activities by protein kinase CK2 phosphorylation. (PubMed id 15637053)1, 2, 9 Yanagawa T.... Raz A. (2005)
- Phosphohexose isomerase/autocrine motility factor/neuroleukin/maturation factor is a multifunctional phosphoprotein. (PubMed id 11004567)1, 2, 9 Haga A.... Raz A. (2000)
- Crystal structure of human phosphoglucose isomerase and analysis of the initial catalytic steps. (PubMed id 12573240)1, 2, 9 Cordeiro A.T....Thiemann O.H. (2003)
- Study of the molecular defects in glucose phosphate isomerase- deficient patients affected by chronic hemolytic anemia. (PubMed id 8822952)1, 2, 9 Baronciani L.... Sirchia G. (1996)
- The characterization of gene mutations for human glucose phosphate isomerase deficiency associated with chronic hemolytic anemia. (PubMed id 7989588)1, 2, 9 Xu W. and Beutler E. (1994)
- Human glucose phosphate isomerase: exon mapping and g ene structure. (PubMed id 8575767)1, 3, 9 Xu W....Beutler E. (1995)
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External Searches for GPI gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing GPI gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing GPI gene
(According to HUGE)
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Specialized Databases showing GPI gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for GPI | Pharmacogenomics, SNPs, Pathways | | ATLAS Chromosomes in Cancer entry for GPI | Genetics and Cytogenetics in Oncology and Haematology | | SHMPD | http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=GPI | | Wikipedia | http://en.wikipedia.org/wiki/Phosphoglucose_isomerase | | NIEHS-SNPs | http://egp.gs.washington.edu/data/gpi/ |
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About This Section
| Patent Information for GPI gene:
Search GeneIP for patents involving GPI
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for GPI gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | OriGene Antibodies for GPI | | OriGene shRNA RFP for GPI | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GPI | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GPI | | | OriGene Protein Over-expression Lysate for GPI | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for GPI | | OriGene 3'-UTR Clone for GPI | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GPI | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GPI | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for GPI | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPI |
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