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GPI Gene

protein-coding   GIFtS: 71
GCID: GC19P034855

Glucose-6-Phosphate Isomerase

(Previous name: glucose phosphate isomerase)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glucose-6-Phosphate Isomerase1 2     EC 5.3.1.93 8
Glucose Phosphate Isomerase1 2     GNPI2
Autocrine Motility Factor2 3     SA362
Phosphoglucose Isomerase2 3     Hexose Monophosphate Isomerase2
Phosphohexose Isomerase2 3     Hexosephosphate Isomerase2
Sperm Antigen 362 3     neuroleukin2
AMF2 3     oxoisomerase2
NLK2 3     phosphohexomutase2
PGI2 3     phosphosaccharomutase2
PHI2 3     Sperm Antigen-362
SA-362 3     Neuroleukin3

External Ids:    HGNC: 44581   Entrez Gene: 28212   Ensembl: ENSG000001052207   OMIM: 1724005   UniProtKB: P067443   

Export aliases for GPI gene to outside databases

Previous GC identifers: GC19P035473 GC19P035305 GC19P039531 GC19P039547 GC19P031360


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GPI Gene:
This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been
identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the
cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts
glucose-6-phophsate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as
neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory
neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as
autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor.
Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be
associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing
results in multiple transcript variants. (provided by RefSeq, Jan 2014)

GeneCards Summary for GPI Gene:
GPI (glucose-6-phosphate isomerase) is a protein-coding gene. Diseases associated with GPI include hydrops fetalis, and glucosephosphate isomerase deficiency. GO annotations related to this gene include cytokine activity and monosaccharide binding.

UniProtKB/Swiss-Prot: G6PI_HUMAN, P06744
Function: Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an
angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor
(Neuroleukin) for spinal and sensory neurons

Gene Wiki entry for GPI (Glucose-6-phosphate isomerase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  NT_187619.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the GPI gene promoter:
         GR   AP-2alpha isoform 3   AP-1   ATF-2   AP-2alpha isoform 2   CRE-BP1   c-Jun   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): GPI promoter sequence
   Search Chromatin IP Primers for GPI

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GPI


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.11   HGNC cytogenetic band: 19q13.1

GPI Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPI gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P034855:  view genomic region     (about GC identifiers)

Start:
34,850,385 bp from pter      End:
34,893,318 bp from pter
Size:
42,934 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: G6PI_HUMAN, P06744 (See protein sequence)
Recommended Name: Glucose-6-phosphate isomerase  
Size: 558 amino acids; 63147 Da
Subunit: Homodimer in the catalytically active form, monomer in the secreted form
5 PDB 3D structures from and Proteopedia for GPI:
1IAT (3D)        1IRI (3D)        1JIQ (3D)        1JLH (3D)        1NUH (3D)    
Secondary accessions: B4DG39 Q9BRD3 Q9BSK5 Q9UHE6
Alternative splicing: 2 isoforms:  P06744-1   P06744-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GPI: NX_P06744

Explore proteomics data for GPI at MOPED

Post-translational modifications: 

  • Phosphorylation at Ser-185 by CK2 has been shown to decrease enzymatic activity and may contribute to secretion by
    a non-classical secretory pathway1
  • ISGylated1
  • Ubiquitination2 at Lys12, Lys73, Lys89, Lys124, Lys194, Lys226, Lys234, Lys241, Lys362, Lys423,
                                 Lys466
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for GPI (P06744) (see all 47)
     WGEPGTN  GGSDLGP  WKGYTGK  TTPLEKN 


    See GPI Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_000166.2  NP_001171651.1  NP_001276718.1  NP_001276719.1  

    ENSEMBL proteins: 
     ENSP00000464797   ENSP00000468298   ENSP00000466191   ENSP00000405573   ENSP00000465858  
     ENSP00000464798   ENSP00000467221   ENSP00000348877   ENSP00000468201   ENSP00000467590  
     ENSP00000466851   ENSP00000467670  
    Reactome Protein details: P06744

    GPI Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for GPI
    OriGene Protein Over-expression Lysate for GPI
    OriGene MassSpec for GPI
    OriGene Custom Protein Services for GPI
    GenScript Custom Purified and Recombinant Proteins Services for GPI
    Novus Biologicals GPI Proteins
    Novus Biologicals GPI Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for GPI
    Cloud-Clone Corp. Proteins for GPI

    GPI Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of GPI
    Browse R&D Systems for Antibodies
    OriGene Antibodies for GPI
    OriGene Custom Antibody Services for GPI
    Novus Biologicals GPI Antibodies
    Abcam antibodies for GPI
    Cloud-Clone Corp. Antibodies for GPI
    ThermoFisher Antibody for GPI
    LSBio Antibodies in human, mouse, rat for GPI

    GPI Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GPI
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GPI
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GPI
    Cloud-Clone Corp. CLIAs for GPI


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001672 G6P_Isomerase
     IPR018189 Phosphoglucose_isomerase_CS
     IPR023096 G6P_Isomerase_C

    Graphical View of Domain Structure for InterPro Entry P06744

    ProtoNet protein and cluster: P06744

    1 Blocks protein domain: IPB001672 Phosphoglucose isomerase (PGI)

    UniProtKB/Swiss-Prot: G6PI_HUMAN, P06744
    Similarity: Belongs to the GPI family


    GPI for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: G6PI_HUMAN, P06744
    Function: Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an
    angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor
    (Neuroleukin) for spinal and sensory neurons
    Catalytic activity: D-glucose 6-phosphate = D-fructose 6-phosphate

         Genatlas biochemistry entry for GPI:
    glucose phosphate isomerase (neuroleukin),glycolysis,gluconeogenesis,energy pathways

         Enzyme Number (IUBMB): EC 5.3.1.91 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004347glucose-6-phosphate isomerase activity TAS--
    GO:0005125cytokine activity IEA--
    GO:0008083growth factor activity IEA--
    GO:0016866intramolecular transferase activity IEA--
    GO:0048029monosaccharide binding IEA--
         
    GPI for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 11 alleles(MGI details for Gpi1):
     cardiovascular system  embryogenesis  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  liver/biliary system  mortality/aging  no phenotypic analysis  respiratory system 

    GPI for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GPI
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GPI

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GPI
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GPI

    miRNA
    Products:
        
    miRTarBase miRNAs that target GPI:
    hsa-mir-346 (MIRT042705), hsa-mir-92b-5p (MIRT037791), hsa-mir-20a-3p (MIRT038973), hsa-mir-17-5p (MIRT050947), hsa-mir-1180-3p (MIRT035941), hsa-mir-1229-3p (MIRT036364), hsa-mir-34a-5p (MIRT025482), hsa-mir-193b-3p (MIRT041374), hsa-mir-149-5p (MIRT045497), hsa-let-7b-5p (MIRT052162), hsa-mir-331-3p (MIRT043341), hsa-mir-760 (MIRT036760), hsa-mir-296-3p (MIRT038387), hsa-mir-1296-5p (MIRT036093), hsa-mir-671-5p (MIRT039256)

    Block miRNA regulation of human, mouse, rat GPI using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GPI (see all 9):
    hsa-miR-330-5p hsa-miR-29a hsa-miR-29c hsa-miR-3157-5p hsa-miR-3907 hsa-miR-3126-5p hsa-miR-326 hsa-miR-1207-3p
    SwitchGear 3'UTR luciferase reporter plasmidGPI 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GPI
    Predesigned siRNA for gene silencing in human, mouse, rat GPI

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GPI

    Clone
    Products:
         
    OriGene clones in human, mouse for GPI (see all 11)
    OriGene ORF clones in mouse, rat for GPI
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GPI (NM_000175)
    Sino Biological Human cDNA Clone for GPI
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GPI
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPI

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GPI
    Browse ESI BIO Cell Lines and PureStem Progenitors for GPI 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPI


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    G6PI_HUMAN, P06744: Cytoplasm. Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol4
    nucleus4
    plasma membrane4
    chloroplast2
    mitochondrion2
    peroxisome2
    cytoskeleton1
    endoplasmic reticulum1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    GPI for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GPI About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Glycolysis and gluconeogenesis short map
    Glycolysis and gluconeogenesis short map 0.60
    Glycolysis / Gluconeogenesis0.46
    Glycolysis and Gluconeogenesis0.60
    Glycolysis0.40
    2Glucuronidation
    Starch and sucrose metabolism0.41
    Glycogen metabolism0.00
    3Carbon metabolism
    Carbon metabolism0.38
    Pentose Phosphate Pathway (Erythrocyte)0.00
    4Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    5Glucose metabolism
    Glucose metabolism0.44
    Gluconeogenesis0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for GPI
        Molecular Mechanisms of Cancer

    2 GeneGo (Thomson Reuters) Pathways for GPI
        Glycogen metabolism
    Glycolysis and gluconeogenesis (short map)

    1 BioSystems Pathway for GPI
        Glycolysis and Gluconeogenesis


    2 Reactome Pathways for GPI
        Gluconeogenesis
    Glycolysis

    1 PharmGKB Pathway for GPI
        Pentose Phosphate Pathway (Erythrocyte)

    Selected Kegg Pathways  (Kegg details for GPI) (see all 6):
        Glycolysis / Gluconeogenesis
    Pentose phosphate pathway
    Starch and sucrose metabolism
    Amino sugar and nucleotide sugar metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: G6PI_HUMAN, P06744
    Pathway: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from
    D-glucose: step 2/4


    GPI for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GPI (see all 7): 

              Neurogenesis in human mouse rat
              Growth Factors in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GPI

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GPI (P067443 ENSP000003488774) via UniProtKB, MINT, STRING, and/or I2D (see all 167)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GPAA1O432923, ENSP000003472064I2D: score=2 STRING: ENSP00000347206
    ALG12Q9BV103, ENSP000003338134I2D: score=1 STRING: ENSP00000333813
    HSPA9P386463, ENSP000002971854I2D: score=1 STRING: ENSP00000297185
    NAP1L4Q997333, ENSP000003699154I2D: score=1 STRING: ENSP00000369915
    G6PDP114133, ENSP000003771924I2D: score=1 STRING: ENSP00000377192
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006006glucose metabolic process TAS--
    GO:0006094gluconeogenesis TAS--
    GO:0006096glycolytic process TAS--

    GPI for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GPI (G6PI)

    5 HMDB Compounds for GPI    About this table
    CompoundSynonyms CAS #PubMed Ids
    Beta-D-Fructose 6-phosphatebeta-D-Fructose 6-phosphate (see all 2)----
    Beta-D-Glucose 6-phosphatebeta-D-glucose 6-(dihydrogen phosphate) (see all 3)----
    D-Glucose(+)-Glucose (see all 23)50-99-7--
    Fructose 6-phosphateD-Fructose 6-phosphate (see all 13)643-13-0--
    Glucose 6-phosphateD(+)-Glucopyranose 6-phosphate (see all 11)56-73-5--

    8 DrugBank Compounds for GPI    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    5-Phospho-D-Arabinohydroxamic Acid-- --target--17139284 17016423 10592235
    5-Phosphoarabinonic Acid-- --target--17139284 17016423 10592235
    6-Phosphogluconic Acid-- --target--17139284 17016423 10592235
    Alpha-D-Glucose-6-Phosphate-- --target--17139284 17016423 10592235
    Erythose-4-Phosphate-- --target--17139284 17016423 10592235
    Glucose-6-Phosphate-- 56-73-5target--17139284 17016423 10592235
    Sorbitol 6-phosphate1-O-phosphono-D-glucitol (see all 2)20479-58-7target--17139284 17016423 10592235
    Fructose-6-Phosphate-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for GPI gene (see all 43)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 6-phosphate 89.2 197 8381960 (5), 15206941 (3), 10916680 (3), 15290745 (2) (see all 96)
    6-phosphogluconate 75.8 12 9041338 (1), 1471744 (1), 18817779 (1), 7737089 (1) (see all 9)
    fructose-6-phosphate 74.6 21 8381960 (3), 15103138 (1), 10916680 (1), 14586688 (1) (see all 11)
    malate 54.9 14 9041338 (1), 9921283 (1), 1471744 (1), 15691124 (1) (see all 9)
    erythrose 4-phosphate 54.1 3 12374700 (1), 15850830 (1)
    glucosamine 6-phosphate 44 1 9864853 (1)
    pyruvate 37.1 12 9362562 (2), 8283448 (1), 1967237 (1), 1846809 (1) (see all 9)
    cellulose acetate 34.2 1 12378792 (1)
    glyceraldehyde 3-phosphate 34 8 1834654 (2), 15752986 (1), 1471744 (1), 17464938 (1) (see all 6)
    lactate 25.5 15 1834654 (2), 8283448 (1), 7885731 (1), 15752986 (1) (see all 11)



    GPI for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for GPI gene (4 alternative transcripts): 
    NM_000175.3  NM_001184722.1  NM_001289789.1  NM_001289790.1  

    Unigene Cluster for GPI:

    Glucose-6-phosphate isomerase
    Hs.466471  [show with all ESTs]
    Unigene Representative Sequence: NM_001184722
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000587521 ENST00000587384 ENST00000592277 ENST00000415930(uc010xrv.2 uc002nvf.3)
    ENST00000588991 ENST00000592144 ENST00000589504 ENST00000590375 ENST00000356487(uc002nvg.2 uc010xrw.2 uc002nvh.1 uc002nvi.2)
    ENST00000589399 ENST00000589640 ENST00000591204 ENST00000586425 ENST00000590362
    ENST00000589985 ENST00000586392 ENST00000586077
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GPI using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GPI (see all 9):
    hsa-miR-330-5p hsa-miR-29a hsa-miR-29c hsa-miR-3157-5p hsa-miR-3907 hsa-miR-3126-5p hsa-miR-326 hsa-miR-1207-3p
    SwitchGear 3'UTR luciferase reporter plasmidGPI 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GPI
    Predesigned siRNA for gene silencing in human, mouse, rat GPI
    Clone
    Products:
         
    OriGene clones in human, mouse for GPI (see all 11)
    OriGene ORF clones in mouse, rat for GPI
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GPI (NM_000175)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GPI
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPI
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GPI
    OriGene qSTAR qPCR primer pairs in human, mouse for GPI
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GPI
      QuantiTect SYBR Green Assays in human, mouse, rat GPI
      QuantiFast Probe-based Assays in human, mouse, rat GPI

    Additional mRNA sequence: 

    AK129884.1 AK130102.1 AK293446.1 AK294396.1 AK301103.1 BC004982.1 K03515.1 X16539.1 

    Selected DOTS entries (see all 67):

    DT.100674927  DT.91798987  DT.92389405  DT.100674924  DT.100864718  DT.100674908  DT.97851996  DT.100859652 
    DT.95346616  DT.100674934  DT.100674910  DT.100674906  DT.121476681  DT.92053999  DT.100674925  DT.40193020 
    DT.121476863  DT.100048150  DT.97801200  DT.101965639  DT.91689860  DT.100674903  DT.121476499  DT.121476520 

    Selected AceView cDNA sequences (see all 1209):

    BM928344 CR614183 BQ434523 BQ436535 AA953336 BQ673037 AI191757 BU509419 
    AK025421 CA313187 BM784251 BQ064097 BP372483 BM789827 BX438605 AL516538 
    BQ896923 CK000959 BM676705 BU739976 CR624212 BU739835 BE791522 AI799272 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GPI (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a ·
    SP1:        -                                         -                                                     -                                                   
    SP2:                                                  -                                                                                                         
    SP3:                                                                                                                                                            
    SP4:                                                  -     -     -     -     -                                                                                 
    SP5:                                      -           -                                                                                                         

    ExUns: 16b ^ 17a · 17b ^ 18 ^ 19a · 19b
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for GPI

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GPI expression in normal human tissues (normalized intensities)      GPI embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GPI Expression
    About this image


    GPI expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Thymus (Hematopoietic System)
             Thymus
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
    GPI Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GPI Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.466471
        Pathway & Disease-focused RT2 Profiler PCR Arrays including GPI (see all 7): 
              Neurogenesis in human mouse rat
              Growth Factors in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GPI gene from Selected species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpi11 , 5 glucose phosphate isomerase 11, 5 86.26(n)1
    88.89(a)1
      7 (19.46 cM)5
    147511  NM_008155.31  NP_032181.21 
     342021225 
    chicken
    (Gallus gallus)
    Aves GPI1 glucose-6-phosphate isomerase 75.7(n)
    82.55(a)
      415783  NM_001006128.1  NP_001006128.1 
    lizard
    (Anolis carolinensis)
    Reptilia GPI6
    glucose-6-phosphate isomerase
    78(a)
    1 ↔ 1
    GL343773.1(142574-185909)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.51942 Xenopus laevis transcribed sequence with moderate similarity more 78.12(n)    CD100154.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gpia2 glucose phosphate isomerase a 78.41(n)   246094  AJ306395.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pgi1 , 3 gluconeogenesis phosphogluconate
    dehydrogenase more3
    Phosphoglucose isomerase1
    68(a)3
    67.21(n)1
    68.67(a)1
      44F63
    358861  NM_165636.11  NP_724724.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y87G2A.83
    gpi-11
    glucose-6-phosphate isomerase3
    gpi-11
    68(a)3
    62.04(n)1
    68.19(a)1
      I(13584707-13589480)3
    1732271  NM_001026667.51  NP_001021838.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PGI1(YBR196C)4
    PGI11
    Glycolytic enzyme phosphoglucose isomerase, catalyzes more4
    PGI11
    57.93(n)1
    59.11(a)1
      2(613900-612236)4
    8524951, 4  NP_009755.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G427401 AT5G42740 52.98(n)
    50.39(a)
      834283  NM_123638.4  NP_199088.1 
    rice
    (Oryza sativa)
    Liliopsida D45218.12   -- 74.57(n)    D45218.1 


    ENSEMBL Gene Tree for GPI (if available)
    TreeFam Gene Tree for GPI (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GPI (see all 1022)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs617546341,2,,4
    CHemolytic anemia, non-spherocytic, due to glucose phosphate isomerase deficiency (HA-GPID)4 pathogenic135027948(+) AGAGAC/TGGCGA 4 T M mis10--------
    rs343066181,2,,4
    CHemolytic anemia, non-spherocytic, due to glucose phosphate isomerase deficiency (HA-GPID)4 --35042252(-) TGGCCG/AACCAC 4 /S /L mis13Minor allele frequency- A:0.02NA 68
    VAR_0025344
    Hemolytic anemia, non-spherocytic, due to glucose phosphate isomerase deficiency (HA-GPID)4--see VAR_0025342 L F mis40--------
    VAR_0025174
    Hemolytic anemia, non-spherocytic, due to glucose phosphate isomerase deficiency (HA-GPID)4--see VAR_0025172 H P mis40--------
    VAR_0025354
    Hemolytic anemia, non-spherocytic, due to glucose phosphate isomerase deficiency (HA-GPID)4--see VAR_0025352 E K mis40--------
    VAR_0025304
    Hemolytic anemia, non-spherocytic, due to glucose phosphate isomerase deficiency (HA-GPID)4--see VAR_0025302 R H mis40--------
    VAR_0025384
    Hemolytic anemia, non-spherocytic, due to glucose phosphate isomerase deficiency (HA-GPID)4--see VAR_0025382 D N mis40--------
    VAR_0025244
    Hemolytic anemia, non-spherocytic, due to glucose phosphate isomerase deficiency (HA-GPID)4--see VAR_0025242 R H mis40--------
    VAR_0025264
    Hemolytic anemia, non-spherocytic, due to glucose phosphate isomerase deficiency (HA-GPID)4--see VAR_0025262 A P mis40--------
    VAR_0025294
    Hemolytic anemia, non-spherocytic, due to glucose phosphate isomerase deficiency (HA-GPID)4--see VAR_0025292 R C mis40--------

    HapMap Linkage Disequilibrium report for GPI (34850385 - 34893318 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for GPI:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509738CNV Insertion20534489
    esv2864CNV Complex18987735

    Human Gene Mutation Database (HGMD): GPI
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GPI
    DNA2.0 Custom Variant and Variant Library Synthesis for GPI

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 172400   
    OMIM disorders: 613470  
    UniProtKB/Swiss-Prot: G6PI_HUMAN, P06744
  • Hemolytic anemia, non-spherocytic, due to glucose phosphate isomerase deficiency (HA-GPID) [MIM:613470]:
    A form of anemia in which there is no abnormal hemoglobin or spherocytosis. It is caused by glucose phosphate
    isomerase deficiency. Note=The disease is caused by mutations affecting the gene represented in this entry

  • Selected diseases for GPI (see all 65):    About MalaCards
    hydrops fetalis    glucosephosphate isomerase deficiency    hemolytic anemia    chronic intestinal vascular insufficiency
    congenital nonspherocytic hemolytic anemia    enamel erosion    dentine erosion    root caries
    chickenpox    primary hyperoxaluria    leishmaniasis    cutaneous leishmaniasis
    synovitis    chordoma    fibrosarcoma    acquired immunodeficiency syndrome
    myoclonus    cerebrovascular disease    antiphospholipid syndrome    rheumatoid arthritis

    9 diseases from the University of Copenhagen DISEASES database for GPI:
    Enamel erosion     Dentine erosion     Primary hyperoxaluria     Root caries
    Anemia     Arthritis     Gingivitis     Cancer
    Leishmaniasis

    GPI for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for GPI gene (see all 40)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hereditary nonspherocytic hemolytic anemia 81 6 7927011 (2), 9446754 (1), 8218542 (1), 17041899 (1)
    anemia hemolytic 66.5 30 9362562 (3), 11371164 (2), 8417789 (2), 9856489 (2) (see all 15)
    anemia hemolytic congenital 62.5 4 8822954 (1), 12737943 (1), 9616041 (1)
    arthritis 59.6 43 15290745 (3), 15320914 (3), 18534002 (3), 12687536 (3) (see all 22)
    rheumatoid arthritis 57.6 36 11477412 (2), 20337045 (2), 19032829 (2), 12730513 (2) (see all 19)
    metastasis 53.7 46 19787266 (3), 15684571 (2), 16294294 (2), 2006007 (1) (see all 33)
    enzyme deficiency 49.5 3 10916680 (1), 7927011 (1)
    tumors 42.6 98 15684571 (5), 14566819 (4), 14968121 (4), 17828376 (3) (see all 49)
    fibrosarcoma 42.5 2 14566819 (1)
    leishmaniasis cutaneous 39.1 1 9574789 (1)

    Genatlas disease: GPI
    hemolytic anemia,hydrops fetalis

    Genetic Association Database (GAD): GPI
    Human Genome Epidemiology (HuGE) Navigator: GPI (10 documents)

    Export disorders for GPI gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GPI gene, integrated from 10 sources (see all 320):
    (articles sorted by number of sources associating them with GPI)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Glucosephosphate isomerase (GPI) deficiency mutations associated with hereditary nonspherocytic hemolytic anemia (HNSHA). (PubMed id 9446754)1, 2, 4, 9 Beutler E.... Forman L. (Blood Cells Mol. Dis. 1997)
    2. Characterization of the 5' end of the gene for human glucose phosphate isomerase (GPI). (PubMed id 2387591)1, 2, 3, 9 Walker J.I.H.... Morgan M.J. (Genomics 1990)
    3. Molecular basis of neurological dysfunction coupled with haemolytic anaemia in human glucose-6-phosphate isomerase (GPI) deficiency. (PubMed id 9856489)1, 2, 9 Kugler W.... Lakomek M. (Hum. Genet. 1998)
    4. Cloning of a glucose phosphate isomerase/neuroleukin-like sperm antigen involved in sperm agglutination. (PubMed id 10727272)1, 2, 9 Yakirevich E. and Naot Y. (Biol. Reprod. 2000)
    5. Differential regulation of phosphoglucose isomerase/autocrine motility factor activities by protein kinase CK2 phosphorylation. (PubMed id 15637053)1, 2, 9 Yanagawa T.... Raz A. (J. Biol. Chem. 2005)
    6. Phosphohexose isomerase/autocrine motility factor/neuroleukin/maturation factor is a multifunctional phosphoprotein. (PubMed id 11004567)1, 2, 9 Haga A.... Raz A. (Biochim. Biophys. Acta 2000)
    7. Crystal structure of human phosphoglucose isomerase and analysis of the initial catalytic steps. (PubMed id 12573240)1, 2, 9 Cordeiro A.T....Thiemann O.H. (Biochim. Biophys. Acta 2003)
    8. Study of the molecular defects in glucose phosphate isomerase- deficient patients affected by chronic hemolytic anemia. (PubMed id 8822952)1, 2, 9 Baronciani L.... Sirchia G. (Blood 1996)
    9. The characterization of gene mutations for human glucose phosphate isomerase deficiency associated with chronic hemolytic anemia. (PubMed id 7989588)1, 2, 9 Xu W. and Beutler E. (J. Clin. Invest. 1994)
    10. Human glucose phosphate isomerase: exon mapping and gene structure. (PubMed id 8575767)1, 3, 9 Xu W....Beutler E. (Genomics 1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2821 HGNC: 4458 AceView: GPIandMGC13096 Ensembl:ENSG00000105220 euGenes: HUgn2821
    ECgene: GPI Kegg: 2821 H-InvDB: GPI

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GPI Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GPI Genetics and Cytogenetics in Oncology and Haematology
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=GPI
    Wikipedia http://en.wikipedia.org/wiki/Phosphoglucose_isomerase
    NIEHS-SNPshttp://egp.gs.washington.edu/data/gpi/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GPI gene:
    Search GeneIP for patents involving GPI

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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