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GPI Gene

protein-coding GIFtS: 71

GC19P039547

glucose phosphate isomerase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AMF ^¹, ², ³
EC 5.3.1.9 ^³
GNPI ^²
NLK ^¹, ², ³
Neuroleukin ^³
PGI ^², ³
PHI ^², ³
SA-36 ^³
SA36 ^²
neuroleukin ^²
oxoisomerase ^²
phosphohexomutase ^²
phosphosaccharomutase ^²

Descriptions
Autocrine motility factor ^², ³
Phosphoglucose isomerase ^², ³
Phosphohexose isomerase ^², ³
Sperm antigen 36 ^³
glucose phosphate isomerase ^²
glucose-6-phosphate isomerase ^²
hexose monophosphate isomerase ^²
hexosephosphate isomerase ^²
sperm antigen-36 ^²

External Ids
HGNC: 4458¹
Entrez Gene: 2821²
UniProtKB: P06744³
Ensembl: ENSG00000105220⁷

Search outside databases for aliases for GPI gene

Previous GC identifers: GC19P035473 GC19P035305 GC19P039531

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for GPI:

This gene belongs to the GPI family whose members encode multifunctional phosphoglucose isomerase

proteins involved in energy pathways. The protein encoded by this gene is a dimeric enzyme that

catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate. The

protein functions in different capacities inside and outside the cell. In the cytoplasm, the gene

product is involved in glycolysis and gluconeogenesis, while outside the cell it functions as a

neurotrophic factor for spinal and sensory neurons. Defects in this gene are the cause of

nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops

fetalis, immediate neonatal death and neurological impairment. [provided by RefSeq]

UniProtKB/Swiss-Prot: G6PI_HUMAN, P06744

Function: Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted

cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a

neurotrophic factor (Neuroleukin) for spinal and sensory neurons

Gene Wiki entry for GPI

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GPI gene

Entrez Gene cytogenetic band: 19q13.1 Ensembl cytogenetic band: 19q13.11 HGNC cytogenetic band: 19q13.1

GPI Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P039547: (about GC identifiers)

Start:	39,547,909 bp from pter
End:	39,583,076 bp from pter
Size:	35,168 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000019.8 NT_011109.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: G6PI_HUMAN, P06744 (See protein sequence)

Recommended Name: Glucose-6-phosphate isomerase

Size: 558 amino acids; 63147 Da

Subunit: Homodimer in the catalytically active form, monomer in the secreted form

Subcellular location: Cytoplasm. Secreted

PDB structures from and Proteopedia :

1IAT (3D)

1IRI (3D)

1JIQ (3D)

1JLH (3D)

1NUH (3D)

Secondary accessions: Q9BRD3 Q9BSK5 Q9UHE6

Post-translational modifications:

Phosphorylation at Ser-185 by CK2 has been shown to decrease enzymatic activity and may contribute

to secretion by a non-classical secretory pathway¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000166.2

ENSEMBL proteins:

ENSP00000376067 ENSP00000348877

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Glucose 6 phosphate isomerase)
	Human Recombinant Proteins from Abnova (GPI)

OriGene Purified Recombinant Human Protein: GPI

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IEA	--
GO:0005737	cytoplasm	IEA	--

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Antibodies for GPI:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for GPI
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Glucose 6 phosphate isomerase), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (GPI)
	Novus Biologicals Antibodies for GPI

Assays for GPI:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P06744

ProtoNet protein and cluster: P06744

1 Blocks protein family: IPB001672 Phosphoglucose isomerase (PGI)

UniProtKB/Swiss-Prot: G6PI_HUMAN, P06744

Similarity: Belongs to the GPI family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GPI)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GPI)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000175

Applied Biosystems Silencer® siRNAs for GPI

Sigma-Aldrich siRNA for GPI

Sigma-Aldrich shRNA for GPI

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for GPI
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000175
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000175
untagged cDNA clone in CMV expression vector: NM_000175

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000175

UniProtKB/Swiss-Prot: G6PI_HUMAN, P06744

Function: Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted

cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a

neurotrophic factor (Neuroleukin) for spinal and sensory neurons

Catalytic activity: D-glucose 6-phosphate = D-fructose 6-phosphate

Enzyme Number (IUBMB): EC 5.3.1.9

Genatlas biochemistry entry for GPI:

glucose phosphate isomerase (neuroleukin),glycolysis,gluconeogenesis,energy pathways

8 MGI mutant phenotypes (inferred from 14 alleles) (MGI details for Gpi1):

embryogenesis	growth/size	hematopoietic system	immune system	lethality-postnatal
lethality-prenatal/perinatal	liver/biliary system	no phenotypic analysis

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004347	glucose-6-phosphate isomerase activity	IEA	--
GO:0005125	cytokine activity	IEA	--
GO:0005515	protein binding	IEA	--
GO:0008083	growth factor activity	IEA	--
GO:0016853	isomerase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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3 Sigma-Aldrich "Your Favorite Gene" Pathways for GPI (Your Favorite Gene powered by Ingenuity)

Pentose Phosphate Pathway
Glycolysis/Gluconeogenesis
Starch and Sucrose Metabolism

GeneDecks GPI for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: G6PI_HUMAN, P06744

Pathway: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate

from D-glucose: step 2/4

Gene Network Central^TM Interacting Genes and Proteins Network for GPI

5/70 Interacting proteins for GPI (ENSP00000348877³) via UniProtKB, MINT, and/or STRING (see all 70 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
G6PD	ENSP00000291567³	STRING (score=.997)
TPI1	ENSP00000371705³	STRING (score=.992)
AMFR	ENSP00000290649³	STRING (score=.978)
MPI	ENSP00000318318³	STRING (score=.974)
HK1	ENSP00000348697³	STRING (score=.973)

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005975	carbohydrate metabolic process	NAS	8575767
GO:0006094	gluconeogenesis	IEA	--
GO:0006096	glycolysis	IEA	--
GO:0006959	humoral immune response	TAS	3020690
GO:0007599	hemostasis	TAS	7435496

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for GPI
10/28 Novoseek chemical compound relationships for GPI gene (see all 28 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
glucose 6-phosphate	88.68	178	8381960 (5), 15206941 (3), 10916680 (3), 15290745 (2) (see all 87)
6-phosphogluconate	76.44	12	9041338 (1), 1471744 (1), 18817779 (1), 7737089 (1) (see all 9)
fructose-6-phosphate	74.05	19	8381960 (3), 15103138 (1), 10916680 (1), 14586688 (1) (see all 10)
erythrose 4-phosphate	55.20	3	12374700 (1), 15850830 (1)
glucosamine 6-phosphate	45.32	1	9864853 (1)
pyruvate	38.54	12	9362562 (2), 8283448 (1), 1967237 (1), 1846809 (1) (see all 9)
glyceraldehyde 3-phosphate	35.56	8	1834654 (2), 15752986 (1), 1471744 (1), 17464938 (1) (see all 6)
isocitrate	19.88	3	1471744 (1), 8625862 (1)
udpglucose	19.34	1	2287590 (1)
mannose 6-phosphate	19.31	9	8381960 (5), 1471744 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GPI)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GPI)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000175

Sigma-Aldrich siRNA for GPI

Sigma-Aldrich shRNA for GPI

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000175

REFSEQ mRNAs for GPI gene:

NM_000175.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000175

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000175
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000175
                                 untagged cDNA clone in CMV expression vector: NM_000175

Additional cDNA sequence:

AK129884.1 AK130102.1 AK293446.1 AK294396.1 AK301103.1 BC004982.1 BX641158.1 CR599066.1

CR600477.1 CR600588.1 CR603258.1 CR606478.1 CR614183.1 CR620238.1 CR620767.1 CR624212.1

K03515.1 X16539.1

24/67 DOTS entries (see all 67 ):

DT.100674927 DT.91798987 DT.92389405 DT.100674924 DT.100864718 DT.100674908 DT.97851996 DT.100859652

DT.95346616 DT.100674934 DT.100674910 DT.100674906 DT.121476681 DT.92053999 DT.100674925 DT.40193020

DT.121476863 DT.100048150 DT.97801200 DT.101965639 DT.91689860 DT.100674903 DT.121476499 DT.121476520

24/1209 AceView cDNA sequences (see all 1209 ):

AU143478 BP360395 BQ918218 BE888183 BP347030 BQ573898 BM974054 BQ059118

BM802483 AL536626 CR594354 AL518041 BX344466 BE140526 CB268787 BU149544

BP334348 BQ348185 BG036512 CR592665 BQ691326 BQ675954 BG698031 BM469077

highest scoring ESTs for GPI:

K03515 AA256833 AA295747 AA306849 AA307028 AA363983 AA368873 AA384500 AA426535 AA550881

Unigene Cluster for GPI:

Glucose phosphate isomerase

Hs.466471 [show with all ESTs]

Unigene Representative Sequence: BX641158

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for GPI (see all 10 )

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4	^	5a	·	5b	·	5c	^	6	^	7a	·	7b	·	7c	^	8	^	9a	·	9b	^	10	^	11a	·	11b	·	11c	^	12	^	13	^	14a	·	14b	^	15	^	16a	·
SP1:			-														-																		-
SP2:																	-
SP3:
SP4:																	-		-		-		-		-
SP5:													-				-

ExUns:	16b	^	17a	·	17b	^	18	^	19a	·	19b
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for GPI

2 Ensembl transcripts including schematic representations:

ENST00000392234 ENST00000356487

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

GPI expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GPI

¹ / ² / ³

6 probe-sets matching GPI gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39122_at²^{, 3}	U95-A	1	1.00	1.00	0.92	0.94	K03515	1.00	0.90	0.95	1
72392_at²^{, 3}	U95-D	1	0.62	1.00	0.96	1.06	AI432513	0.20	1.00	0.72	1
208308_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000175	0.60	0.83	0.73	1
210848_at*²^{, 3}	U133-A	1	1.00	1.00	--	--	AF187554	0.40	0.75	0.60	1
208308_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210848_at*²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TAGAAAAATA

SOURCE GeneReport for Unigene cluster: Hs.466471
Expression variation in blood from EXPOLDB for GPI

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GPI gene from 5/23 species (see all 23 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GPI¹	--	glucose phosphate isomerase	90.32(n) 92.83(a)	611942 XM_862867.1 XP_867960.1
cow (Bos taurus)	GPI¹	--	glucose phosphate isomerase	90.41(n) 91.55(a)	280808 NM_001040471.1 NP_001035561.1
rat (Rattus norvegicus)	Gpi¹	--	glucose phosphate isomerase	86.18(n) 88.33(a)	292804 NM_207592.1 NP_997475.1
mouse (Mus musculus)	Gpi1^{1, 5}	7 (11.00 cM)⁵	glucose phosphate isomerase 1^{1, 5}	86.32(n)¹ 88.89(a)¹	14751¹ NM_008155.2¹ NP_032181.1¹ AF108354⁵ AK031081⁵ (see all 31)
chicken (Gallus gallus)	GPI¹	--	glucose phosphate isomerase	75.7(n) 82.55(a)	415783 NM_001006128.1 NP_001006128.1

About this table Species with no ortholog for GPI

ENSEMBL Gene Tree for GPI

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/97 NCBI SNPs in GPI are shown (see all 97 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 69)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs4619515^1,2	C,F,H	39583322(+)	`GACTGG/CAGAAA`	1	--	ng3¹		8	EU EA WA NS NA	726
--	rs8191429^1,2	C,F	39583326(+)	`GGAGAA/TATTGG`	1	--	ng3¹		4	NS NA	310
	rs2230294^1,2	F	39576672(+)	`CTTCCG/ACACGA`	1	H/R	mis¹		1	MN	36
	rs8191416^1,2	C,F,H	39576697(+)	`AACGCC/ACCCGT`	1	A/A	syn¹ ese³		5	NS EU EA WA	598
	rs34604585^1,2	F	39582038(-)	`TTGCCC/GGCAGC`	1	A/A	syn¹		1	NA	78
	rs2377572^1,2	A,C,F,H,O	39568373(+)	`AGACCT/CAAAAA`	1	--	int¹		11	EU EA WA NA	978
	rs4290576^1,2	A,C,F,H	39577298(+)	`GCCTGT/CACTGC`	1	--	int¹		11	EU EA WA NS	1062
	rs2301263^1,2	C,F,H	39582162(+)	`GGGGCA/GTGCCT`	1	--	int¹		6	EA NS EU WA	2074
--	rs8191425^1,2	C,F,H	39579892(+)	`GCAGGC/TCCTGA`	1	--	int¹		9	NS EU EA WA	1014
	rs8108038^1,2	A,C,F	39576846(+)	`CAGCAG/AGATTT`	1	--	int¹		7	NS	656

About this table

HapMap Linkage Disequilibrium images for GPI (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 172400

UniProtKB/Swiss-Prot: G6PI_HUMAN, P06744

Defects in GPI are a cause of hereditary nonspherocytic hemolytic anemia (HA)

[MIM:172400]. Severe GPI deficiency can be associated with hydrops fetalis, immediate neonatal

death and neurological impairment

10/40 Novoseek disease relationships for GPI gene (see all 40 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hereditary nonspherocytic hemolytic anemia	81.10	6	7927011 (2), 9446754 (1), 8218542 (1), 17041899 (1)
anemia hemolytic	67.56	30	9362562 (3), 11371164 (2), 8417789 (2), 9856489 (2) (see all 15)
anemia hemolytic congenital	63.30	4	8822954 (1), 12737943 (1), 9616041 (1)
arthritis	58.34	37	15290745 (3), 15320914 (3), 18534002 (3), 12687536 (3) (see all 20)
rheumatoid arthritis	56.05	34	11477412 (2), 15228189 (2), 12730513 (2), 14508072 (2) (see all 18)
metastasis	54.10	42	15684571 (2), 16294294 (2), 2006007 (1), 7591303 (1) (see all 31)
enzyme deficiency	50.57	3	10916680 (1), 7927011 (1)
tumors	42.62	95	15684571 (5), 14566819 (4), 14968121 (4), 17828376 (3) (see all 47)
leishmaniasis cutaneous	40.83	1	9574789 (1)
fibrosarcoma	40.10	2	14566819 (1)

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1 PharmGKB disease relationship for GPI gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12730115

About this table

Genatlas disease: GPI

hemolytic anemia,hydrops fetalis

Human Gene Mutation Database: GPI
Genetic Association Database: GPI

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/259 PubMed articles for GPI gene (see all 259 ):

Glucosephosphate isomerase (GPI) deficiency mutations associated with hereditary nonspherocytic hemolytic anemia (HNSHA). (PubMed id 9446754)^{1, 3, 4, 6} Beutler E.... Forman L. (1997)
Characterization of the 5' end of the gene for human glucose phosphate isomerase (GPI). (PubMed id 2387591)^{1, 2, 3, 4} Walker J.I.H.... Morgan M.J. (1990)
Molecular basis of neurological dysfunction coupled with haemolytic anaemia in human glucose-6-phosphate isomerase (GPI) deficiency. (PubMed id 9856489)^{1, 3, 4} Kugler W.... Lakomek M. (1998)
Cloning of a glucose phosphate isomerase/neuroleukin-like sperm antigen involved in sperm agglutination. (PubMed id 10727272)^{1, 3, 4} Yakirevich E. and Naot Y. (2000)
Differential regulation of phosphoglucose isomerase/autocrine motility factor activities by protein kinase CK2 phosphorylation. (PubMed id 15637053)^{1, 3, 4} Yanagawa T....Raz A. (2005)
Phosphohexose isomerase/autocrine motility factor/neuroleukin/maturation factor is a multifunctional phosphoprotein. (PubMed id 11004567)^{1, 3, 4} Haga A....Raz A. (2000)
Crystal structure of human phosphoglucose isomerase and analysis of the initial catalytic steps. (PubMed id 12573240)^{1, 3, 4} Cordeiro A.T....Thiemann O.H. (2003)
Study of the molecular defects in glucose phosphate isomerase- deficient patients affected by chronic hemolytic anemia. (PubMed id 8822952)^{1, 3, 4} Baronciani L.... Sirchia G. (1996)
The characterization of gene mutations for human glucose phosphate isomerase deficiency associated with chronic hemolytic anemia. (PubMed id 7989588)^{1, 3, 4} Xu W. and Beutler E. (1994)
Molecular analysis of glucose phosphate isomerase deficiency associated with hereditary hemolytic anemia. (PubMed id 8822954)^{1, 3, 4} Kanno H.... Miwa S. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2821	HGNC: 4458	AceView: GPIandMGC13096	Ensembl:ENSG00000105220	euGenes: HUgn2821
ECgene: GPI	H-InvDB: GPI

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for GPI	Genetics and Cytogenetics in Oncology and Haematology
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=GPI
Wikipedia	http://en.wikipedia.org/wiki/Phosphoglucose_isomerase
NIEHS-SNPs	http://egp.gs.washington.edu/data/gpi/

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About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for GPI:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

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Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
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Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GPI-related products

	Millipore Custom Antibody & Bulk Services
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	Predesigned and custom siRNAs for GPI		Antibodies for GPI
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	Lentivirus-delivered shRNAs for GPI		Browse small molecules at Sigma-Aldrich
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	Recombinant Proteins (Glucose 6 phosphate isomerase)
	Antibodies (Glucose 6 phosphate isomerase)

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	Western blot validated antibodies
	shRNA in GFP-retroviral vector

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Antibodies for GPI

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
GPI Gene at Home site.
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GPI Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for GPI

Summaries
for GPI

Genomic Location
for GPI

Proteins
for GPI

Protein Domains/
Families
for GPI

Gene Function
for GPI

Pathways & Interactions
for GPI

Drugs & Compounds
for GPI

Transcripts
for GPI

Expression
for GPI

Orthologs
for GPI

Paralogs
for GPI

SNPs/Variants
for GPI

Disorders & Mutations
for GPI

Medical News
for GPI

Publications
for GPI

Search for GPI

Genome Databases showing GPI

Other Databases showing GPI

Specialized Databases showing GPI

Licensable Technologies
for GPI

Services
for GPI

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GPI (Gene Symbol)
AMF
EC 5.3.1.9
GNPI
NLK
Neuroleukin
PGI
PHI
SA-36
SA36
neuroleukin
oxoisomerase
phosphohexomutase
phosphosaccharomutase
Autocrine motility factor
Phosphoglucose isomerase
Phosphohexose isomerase
Sperm antigen 36
glucose phosphate isomerase
glucose-6-phosphate isomerase
hexose monophosphate isomerase
hexosephosphate isomerase
sperm antigen-36

GPI Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor GPI

Summariesfor GPI

Genomic Locationfor GPI

Proteinsfor GPI

Protein Domains/Familiesfor GPI

Gene Functionfor GPI

Pathways & Interactionsfor GPI

Drugs & Compoundsfor GPI

Transcriptsfor GPI

Expression for GPI

Orthologsfor GPI

Paralogsfor GPI

SNPs/Variantsfor GPI

Disorders & Mutationsfor GPI

Medical Newsfor GPI

Publicationsfor GPI

Search for GPI

Genome Databases showing GPI

Other Databases showing GPI

Specialized Databases showing GPI

Licensable Technologiesfor GPI

Servicesfor GPI

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GPI

Summaries
for GPI

Genomic Location
for GPI

Proteins
for GPI

Protein Domains/
Families
for GPI

Gene Function
for GPI

Pathways & Interactions
for GPI

Drugs & Compounds
for GPI

Transcripts
for GPI

Expression
for GPI

Orthologs
for GPI

Paralogs
for GPI

SNPs/Variants
for GPI

Disorders & Mutations
for GPI

Medical News
for GPI

Publications
for GPI

Licensable Technologies
for GPI

Services
for GPI