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Aliases for GPHB5 Gene

Aliases for GPHB5 Gene

  • Glycoprotein Hormone Beta 5 2 3
  • Thyrostimulin Subunit Beta 3 4
  • ZLUT1 3 4
  • GPB5 3 4
  • Glycoprotein Hormone Beta Subunit 3
  • Glycoprotein Beta 5 3
  • B5 3

External Ids for GPHB5 Gene

Previous GeneCards Identifiers for GPHB5 Gene

  • GC14M062849
  • GC14M063779
  • GC14M043946

Summaries for GPHB5 Gene

Entrez Gene Summary for GPHB5 Gene

  • GPHB5 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002 [PubMed 12089349]).[supplied by OMIM, Mar 2008]

GeneCards Summary for GPHB5 Gene

GPHB5 (Glycoprotein Hormone Beta 5) is a Protein Coding gene. GO annotations related to this gene include hormone activity.

UniProtKB/Swiss-Prot for GPHB5 Gene

  • Stimulates the thyroid. Binds and activates THSR, leading to increased cAMP production.

Gene Wiki entry for GPHB5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPHB5 Gene

Genomics for GPHB5 Gene

Regulatory Elements for GPHB5 Gene

Genomic Location for GPHB5 Gene

Chromosome:
14
Start:
63,312,835 bp from pter
End:
63,318,879 bp from pter
Size:
6,045 bases
Orientation:
Minus strand

Genomic View for GPHB5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPHB5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPHB5 Gene

Proteins for GPHB5 Gene

  • Protein details for GPHB5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YW7-GPHB5_HUMAN
    Recommended name:
    Glycoprotein hormone beta-5
    Protein Accession:
    Q86YW7
    Secondary Accessions:
    • Q6NTD0
    • Q8NFW2

    Protein attributes for GPHB5 Gene

    Size:
    130 amino acids
    Molecular mass:
    14232 Da
    Quaternary structure:
    • Heterodimer with GPHA2

neXtProt entry for GPHB5 Gene

Proteomics data for GPHB5 Gene at MOPED

Post-translational modifications for GPHB5 Gene

Other Protein References for GPHB5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPHB5 Gene

Domains & Families for GPHB5 Gene

Suggested Antigen Peptide Sequences for GPHB5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86YW7

UniProtKB/Swiss-Prot:

GPHB5_HUMAN :
  • Belongs to the glycoprotein hormones subunit beta family.
Family:
  • Belongs to the glycoprotein hormones subunit beta family.
genes like me logo Genes that share domains with GPHB5: view

No data available for Gene Families for GPHB5 Gene

Function for GPHB5 Gene

Molecular function for GPHB5 Gene

UniProtKB/Swiss-Prot Function:
Stimulates the thyroid. Binds and activates THSR, leading to increased cAMP production.

Gene Ontology (GO) - Molecular Function for GPHB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity IEA --
genes like me logo Genes that share ontologies with GPHB5: view

Phenotypes for GPHB5 Gene

MGI mutant phenotypes for GPHB5:
inferred from 2 alleles
genes like me logo Genes that share phenotypes with GPHB5: view

Animal Models for GPHB5 Gene

MGI Knock Outs for GPHB5:

Animal Model Products

CRISPR Products

miRNA for GPHB5 Gene

miRTarBase miRNAs that target GPHB5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPHB5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for GPHB5 Gene

Localization for GPHB5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPHB5 Gene

Secreted.

Gene Ontology (GO) - Cellular Components for GPHB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with GPHB5: view

No data available for Subcellular locations from COMPARTMENTS for GPHB5 Gene

Pathways & Interactions for GPHB5 Gene

SuperPathways for GPHB5 Gene

No Data Available

Interacting Proteins for GPHB5 Gene

Gene Ontology (GO) - Biological Process for GPHB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002155 regulation of thyroid hormone mediated signaling pathway IEA --
genes like me logo Genes that share ontologies with GPHB5: view

No data available for Pathways by source and SIGNOR curated interactions for GPHB5 Gene

Drugs & Compounds for GPHB5 Gene

(1) Drugs for GPHB5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
genes like me logo Genes that share compounds with GPHB5: view

Transcripts for GPHB5 Gene

mRNA/cDNA for GPHB5 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPHB5 Gene

Glycoprotein hormone beta 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPHB5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPHB5 Gene

No ASD Table

Relevant External Links for GPHB5 Gene

GeneLoc Exon Structure for
GPHB5
ECgene alternative splicing isoforms for
GPHB5

Expression for GPHB5 Gene

mRNA expression in normal human tissues for GPHB5 Gene

SOURCE GeneReport for Unigene cluster for GPHB5 Gene Hs.375028

mRNA Expression by UniProt/SwissProt for GPHB5 Gene

Q86YW7-GPHB5_HUMAN
Tissue specificity: Highly expressed in brain and at low levels in pituitary. Also found in retina, testis and skin but not in pancreas, parotid, kidney, stomach, liver, colon, small intestine, thyroid, brain or adrenal gland. In pituitary, colocalizes with ACTH, suggesting that it is located in corticotrophs.
genes like me logo Genes that share expression patterns with GPHB5: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for GPHB5 Gene

Orthologs for GPHB5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPHB5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPHB5 35
  • 90.51 (n)
  • 91.54 (a)
dog
(Canis familiaris)
Mammalia GPHB5 35
  • 90.26 (n)
  • 92.31 (a)
mouse
(Mus musculus)
Mammalia Gphb5 35
  • 85.64 (n)
  • 86.92 (a)
Gphb5 16
chimpanzee
(Pan troglodytes)
Mammalia GPHB5 35
  • 99.74 (n)
  • 100 (a)
rat
(Rattus norvegicus)
Mammalia Gphb5 35
  • 86.56 (n)
  • 86.82 (a)
chicken
(Gallus gallus)
Aves LOC428919 35
  • 75.26 (n)
  • 76.56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gphb5 35
  • 68.61 (n)
  • 75.83 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17260 35
zebrafish
(Danio rerio)
Actinopterygii gphb5 35
  • 66.39 (n)
  • 69.75 (a)
Species with no ortholog for GPHB5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPHB5 Gene

ENSEMBL:
Gene Tree for GPHB5 (if available)
TreeFam:
Gene Tree for GPHB5 (if available)

Paralogs for GPHB5 Gene

(1) SIMAP similar genes for GPHB5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GPHB5: view

No data available for Paralogs for GPHB5 Gene

Variants for GPHB5 Gene

Sequence variations from dbSNP and Humsavar for GPHB5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs728525 -- 63,313,998(+) gtacc(C/T)aaaac intron-variant
rs728526 -- 63,314,010(+) gaccc(C/T)ggGAG intron-variant
rs728527 -- 63,314,291(+) cactt(A/C)acttc intron-variant
rs1255578 -- 63,315,341(+) GCCCC(A/G)TAAAA intron-variant
rs1255579 -- 63,317,279(+) CCACA(A/G)ATTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPHB5 Gene

Variant ID Type Subtype PubMed ID
dgv137n21 CNV Gain 19592680
nsv832815 CNV Gain 17160897
dgv87e55 CNV Gain 17911159
nsv519574 CNV Gain 19592680
dgv257n27 CNV Gain 19166990
dgv88e55 CNV Gain 17911159

Relevant External Links for GPHB5 Gene

HapMap Linkage Disequilibrium report
GPHB5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for GPHB5 Gene

Disorders for GPHB5 Gene

Relevant External Links for GPHB5

Genetic Association Database (GAD)
GPHB5
Human Genome Epidemiology (HuGE) Navigator
GPHB5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPHB5
genes like me logo Genes that share disorders with GPHB5: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPHB5 Gene

Publications for GPHB5 Gene

  1. Inflammatory cytokines regulate glycoprotein subunit beta5 of thyrostimulin through nuclear factor-kappaB. (PMID: 19095738) Suzuki C. … Oiso Y. (Endocrinology 2009) 23 67
  2. Expression of the gene for ancestral glycoprotein hormone beta subunit in the nerve cord of amphioxus. (PMID: 19393658) Tando Y. … Kubokawa K. (Gen. Comp. Endocrinol. 2009) 23 67
  3. Comparative structure analyses of cystine knot-containing molecules with eight aminoacyl ring including glycoprotein hormones (GPH) alpha and beta subunits and GPH-related A2 (GPA2) and B5 (GPB5) molecules. (PMID: 19715619) Alvarez E. … Combarnous Y. (Reprod. Biol. Endocrinol. 2009) 23 67
  4. Biochemical roles of the oligosaccharide chains in thyrostimulin, a heterodimeric hormone of glycoprotein hormone subunits alpha 2 (GPA2) and beta 5 (GPB5). (PMID: 18433898) Okajima Y. … Oiso Y. (Regul. Pept. 2008) 23 67
  5. The LIM domain homeobox gene isl-1 is a positive regulator of glycoprotein alpha 2 (GPA2), a subunit of thyrostimulin. (PMID: 17363077) Suzuki C. … Oiso Y. (Regul. Pept. 2007) 23 67

Products for GPHB5 Gene

Sources for GPHB5 Gene

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