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GPER1 Gene

protein-coding   GIFtS: 44
GCID: GC07P001122

G Protein-Coupled Estrogen Receptor 1

(Previous name: G protein-coupled receptor 30)
(Previous symbols: CMKRL2, GPR30, GPER)
  See GPER1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
G Protein-Coupled Estrogen Receptor 11 2 3     G-Protein Coupled Receptor 302 3
CMKRL21 2 3 5     IL8-Related Receptor DRY122 3
GPER1 2 3 5     mER2 3
GPR301 2 3 5     LERGU2
G Protein-Coupled Receptor 301 2     LERGU22
Chemoattractant Receptor-Like 22 3     LyGPR2
Flow-Induced Endothelial G-Protein Coupled Receptor 12 3     Chemokine Receptor-Like 22
Lymphocyte-Derived G-Protein Coupled Receptor2 3     Constitutively Expressed Peptide-Like Receptor2
Membrane Estrogen Receptor2 3     G-Protein Coupled Estrogen Receptor 12
CEPR2 3     Heptahelix Receptor2
DRY122 3     Leucine Rich Protein In GPR30 3'UTR2
FEG-12 3     LYGPR3
GPCR-Br2 3     

External Ids:    HGNC: 44851   Entrez Gene: 28522   Ensembl: ENSG000001648507   OMIM: 6018055   UniProtKB: Q995273   

Export aliases for GPER1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GPER1 Gene:
This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that
localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium
mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore
plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues
with estrogen. Alternate transcriptional splice variants which encode the same protein have been characterized.
(provided by RefSeq, Jul 2008)

GeneCards Summary for GPER1 Gene:
GPER1 (G protein-coupled estrogen receptor 1) is a protein-coding gene. Diseases associated with GPER1 include pain disorder, and breast cancer. GO annotations related to this gene include steroid binding and G-protein coupled receptor activity. An important paralog of this gene is GPR146.

UniProtKB/Swiss-Prot: GPER1_HUMAN, Q99527
Function: G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to
rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium
mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and
subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling
pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular,
endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac
hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by
stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation.
Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta
cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stimulates uterine
epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic
atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules.
Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against
NMDA-induced excitotoxic neuronal death. Increases firing activity and intracellular calcium oscillations in
luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate
during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Involved in the
recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells. Functions also as a receptor for
aldosterone mediating rapid regulation of vascular contractibility through the PI3K/ERK signaling pathway.
Involved in cancer progression regulation. Stimulates cancer-associated fibroblast (CAF) proliferation by a rapid
genomic response through the EGFR/ERK transduction pathway. Associated with EGFR, may act as a transcription
factor activating growth regulatory genes (c-fos, cyclin D1). Promotes integrin alpha-5/beta-1 and fibronectin
(FN) matrix assembly in breast cancer cells

summary for GPER1 Gene:
The GPR30 receptor is an orphan G-protein-coupled receptor that has recently been shown to bind estrogen and
cause estrogen-mediated adenylyl cyclase stimulation. GPR30 is widely distributed in neural, breast cancer,
placental, heart, ovarian, prostate, hepatic, vascular epithelial and lymphoid tissue. The receptor acts
independently of ERalpha and ERbeta and triggers ER-dependent EGFR action.

Gene Wiki entry for GPER1 (GPR30) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for GPER1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): GPER1 promoter sequence
   Search Chromatin IP Primers for GPER1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GPER1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.3   Ensembl cytogenetic band:  7p22.3   HGNC cytogenetic band: 7p22

GPER1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPER1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P001122:  view genomic region     (about GC identifiers)

Start:
1,121,844 bp from pter      End:
1,133,451 bp from pter
Size:
11,608 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 1,180,870-1,187,850     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GPER1_HUMAN, Q99527 (See protein sequence)
Recommended Name: G-protein coupled estrogen receptor 1  
Size: 375 amino acids; 42248 Da
Subunit: Homodimer (Probable). Heterodimer; heterodimerizes with other G-protein-coupled receptor (GPCRs) like
CRHR1, HTR1A and PAQR8. Interacts (via C-terminus tail motif) with DLG4 (via N-terminus tandem pair of PDZ
domains); the interaction is direct and induces the increase of GPER1 protein levels residing at the plasma
membrane surface in a estradiol-independent manner (By similarity). Interacts with RAMP3. Interacts with KRT7 and
KRT8. Interacts with EGFR; the interaction increases after agonist-induced stimulation in cancer-associated
fibroblasts (CAF). Interacts with EGFR and ESR1
Miscellaneous: Does not bind estradiol according to PubMed:18566127 and PubMed:16645038
Caution: Data is conflicting regarding whether it fulfills the criteria of a membrane-bound estrogen receptor
(PubMed=15705806, PubMed=17379646 and PubMed=16780796) or not (PubMed=12193550, PubMed=16645038 and
PubMed:18566127)
Caution: Data is conflicting regarding whether it is localized either at the cell membrane (PM) (PubMed:15539556,
PubMed:21427217, PubMed:21540189, PubMed:21354433, PubMed:21149639 and PubMed:23674134) or at the endoplasmic
reticulum (ER) (PubMed:15705806 and PubMed:18566127)
Secondary accessions: A8K6C5 B5BUJ1 O00143 O43494 Q13631 Q6FHL1 Q96F42 Q99981

Explore the universe of human proteins at neXtProt for GPER1: NX_Q99527

Explore proteomics data for GPER1 at MOPED

Post-translational modifications: 

  • Ubiquitinated; ubiquitination occurs at the plasma membrane and leads to proteasome-mediated degradation1
  • Glycosylated1
  • Glycosylation2 at Asn25, Asn32, Asn44

  • See GPER1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001035055.1  NP_001496.1  NP_001091671.1  

    ENSEMBL proteins: 
     ENSP00000385151   ENSP00000410487   ENSP00000297469   ENSP00000380277   ENSP00000380281  
    Reactome Protein details: Q99527

    GPER1 Human Recombinant Protein Products:

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    Novus Biologicals GPER1 Proteins
    Novus Biologicals GPER1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for GPER1 

     
    antibodies-online proteins for GPER1 (9 products) 

     
    antibodies-online peptides for GPER1

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    GPER1 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for GPER1 
    antibodies-online kits for GPER1 (16 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q99527

    ProtoNet protein and cluster: Q99527

    UniProtKB/Swiss-Prot: GPER1_HUMAN, Q99527
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with GPER1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GPER1_HUMAN, Q99527
    Function: G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to
    rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium
    mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and
    subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling
    pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular,
    endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac
    hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by
    stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation.
    Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta
    cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stimulates uterine
    epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic
    atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules.
    Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against
    NMDA-induced excitotoxic neuronal death. Increases firing activity and intracellular calcium oscillations in
    luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate
    during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Involved in the
    recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells. Functions also as a receptor for
    aldosterone mediating rapid regulation of vascular contractibility through the PI3K/ERK signaling pathway.
    Involved in cancer progression regulation. Stimulates cancer-associated fibroblast (CAF) proliferation by a rapid
    genomic response through the EGFR/ERK transduction pathway. Associated with EGFR, may act as a transcription
    factor activating growth regulatory genes (c-fos, cyclin D1). Promotes integrin alpha-5/beta-1 and fibronectin
    (FN) matrix assembly in breast cancer cells
    Biophysicochemical properties: Kinetic parameters: KM=3.3 mM for 17-beta-estradiol (PubMed:19931550); KM=6.6 mM
    for 17-beta-estradiol (PubMed:15705806); KM=3.3 mM for 17-beta-estradiol (PubMed:15539556);
    Induction: Up-regulated by EGF and TGF-alpha in endometrial, ovarian and breast tumor cells. Up-regulated by
    progestin and by phorbol 12-myristate 13-acetate (PMA) in breast cancer cell lines

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IDA--
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0005496steroid binding IDA15539556
    GO:0005515protein binding IPI--
    GO:0017082mineralocorticoid receptor activity ISS--
         
    Find genes that share ontologies with GPER1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for GPER1:
     Decreased G3BP1 protein expres  Increased cell death HMECs cel 

         11 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Gpr30):
     cardiovascular system  endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  limbs/digits/tail  liver/biliary system  no phenotypic analysis  reproductive system 
     skeleton 

    Find genes that share phenotypes with GPER1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for GPER1: Gper1tm1Cwan Gper1tm1135.2Arte Gper1tm1.1Lmlf

       genOway: Develop your customized and physiologically relevant rodent model for GPER1

    miRNA
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    miRTarBase miRNAs that target GPER1:
    hsa-mir-335-5p (MIRT019084)

    Block miRNA regulation of human, mouse, rat GPER1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate GPER1
    SwitchGear 3'UTR luciferase reporter plasmidGPER1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPER1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GPER1_HUMAN, Q99527: Nucleus. Cytoplasm (By similarity). Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton.
    Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Cytoplasmic
    vesicle membrane; Multi-pass membrane protein. Early endosome. Recycling endosome. Golgi apparatus membrane;
    Multi-pass membrane protein (By similarity). Golgi apparatus, trans-Golgi network. Endoplasmic reticulum
    membrane; Multi-pass membrane protein. Cell projection, dendrite (By similarity). Cell projection, dendritic
    spine membrane; Multi-pass membrane protein (By similarity). Cell projection, axon (By similarity). Cell
    junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Mitochondrion membrane;
    Multi-pass membrane protein (By similarity). Note=Colocalized with BSN to the active zone of presynaptic density.
    Colocalized with DLG4/PSD95 and neurabin-2 PPP1R9B in neuronal synaptosomes (By similarity). Endocytosed in a
    agonist- and arrestin-independent manner. Colocalized with RAMP3 and clathrin-coated pits at the plasma membrane.
    Colocalized with transferrin receptor at the plasma membrane and perinuclear region. Accumulated and colocalized
    with RAB11 proteins in recycling endosomes and trans-Golgi network (TGN), but does neither recycle back to the
    cell surface nor traffics to late endosome or lysosome. Colocalized with calnexin in the endoplasmic reticulum.
    Traffics to intracellular sites via cytokeratin intermediate filaments like KRT7 and KRT8 after constitutive
    endocytosis in epithelial cells. Colocalized with EGFR in the nucleus of agonist-induced cancer-associated
    fibroblasts (CAF)

    Gene Ontology (GO): Selected cellular component terms (see all 29):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005622intracellular ISS--
    GO:0005634nucleus IDA--
    GO:0005635nuclear envelope IDA15705806
    GO:0005737cytoplasm ISS--

    Find genes that share ontologies with GPER1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GPER1 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    Peptide ligand-binding receptors0.60
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Development Endothelin 1 EDNRA signaling
    Estrogen signaling pathway0.34
    4Estrogen signaling pathway
    Estrogen signaling pathway


    Find genes that share SuperPaths with GPER1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for GPER1
        Estrogen signaling pathway
    GPCRs, Class A Rhodopsin-like

    2 Reactome Pathways for GPER1
        Peptide ligand-binding receptors
    G alpha (i) signalling events


    1 Kegg Pathway  (Kegg details for GPER1):
        Estrogen signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GPER1
    Interactions:

        Search GeneGlobe Interaction Network for GPER1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GPER1 (ENSP000002974694) via UniProtKB, MINT, STRING, and/or I2D (see all 143)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADRA2CENSP000003860694STRING: ENSP00000386069
    CCR1ENSP000002961404STRING: ENSP00000296140
    CCR3ENSP000003500034STRING: ENSP00000350003
    CCR5ENSP000002923034STRING: ENSP00000292303
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 50):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001934positive regulation of protein phosphorylation ISS--
    GO:0001956positive regulation of neurotransmitter secretion ISS--
    GO:0002695negative regulation of leukocyte activation IDA--
    GO:0006954inflammatory response IEA--
    GO:0007049cell cycle IEA--

    Find genes that share ontologies with GPER1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for GPER1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    G-36Selective GPR30 antagonist[1392487-51-2]
    G-15High affinity and selective GPR30 antagonist[1161002-05-6]
    G-1Potent and selective GPR30 agonist[881639-98-1]

    6 Novoseek inferred chemical compound relationships for GPER1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrogen 74.6 77 18467441 (5), 11043579 (4), 18420744 (4), 19749156 (4) (see all 27)
    progestin 62.6 16 12193550 (8), 12446589 (2), 15539556 (1), 16289637 (1)
    estradiol 48.4 1 18566127 (1)
    steroid 44.2 7 20228382 (1), 17640985 (1), 18420744 (1), 15511221 (1) (see all 5)
    progesterone 35 2 20228382 (1), 12193550 (1)
    calcium 17.9 2 19131510 (1)



    Find genes that share compounds with GPER1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GPER1 gene (4 alternative transcripts): 
    NM_001039966.1  NM_001505.2  NM_001031682.1  NM_001098201.1  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000401670 ENST00000413368 ENST00000297469(uc010ksd.1) ENST00000397088(uc003skb.2)
    ENST00000397092(uc003sjz.1 uc003ska.1)
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      QuantiTect SYBR Green Assays in human, mouse, rat GPER1
      QuantiFast Probe-based Assays in human, mouse, rat GPER1

    Selected AceView cDNA sequences (see all 75):

    BU732605 BU857553 Y08162 CB106598 BU857973 BQ278731 BC082766 U63917 
    BX101291 AA748990 BM680243 BC011634 BP359982 CR541655 BF941220 BX360399 
    BG824221 CB991744 CD172114 CF147801 CD558521 BE874882 BG338329 AL521050 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GPER1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GPER1 Expression
    About this image


    GPER1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem E15, Meso-prx/latp Progenitor
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    GPER1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GPER1 Protein Expression

    UniProtKB/Swiss-Prot: GPER1_HUMAN, Q99527
    Tissue specificity: Expressed in placenta, endothelial and epithelial cells, non laboring and laboring term
    myometrium, fibroblasts and cancer-associated fibroblasts (CAF), prostate cancer cells and invasive
    adenocarcinoma (at protein level). Ubiquitously expressed, but is most abundant in placenta. In brain regions,
    expressed as a 2.8 kb transcript in basal forebrain, frontal cortex, thalamus, hippocampus, caudate and putamen

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for GPER1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpr305
    Gper11
    G protein-coupled receptor 305
    G protein-coupled estrogen receptor 11
    84.53(n)1
    86.93(a)1
      5 (78.58 cM)5
    768541  NM_029771.31  NP_084047.21 
     1394231515 
    chicken
    (Gallus gallus)
    Aves GPER1 G protein-coupled estrogen receptor 1 71.06(n)
    77.59(a)
      416457  NM_001162405.1  NP_001155877.1 
    lizard
    (Anolis carolinensis)
    Reptilia GPER16
    G protein-coupled estrogen receptor 1
    79(a)
    1 ↔ 1
    GL343327.1(1445250-1446293)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia gper11 G protein-coupled estrogen receptor 1 67.5(n)
    70.36(a)
      100135723  NM_001114253.1  NP_001107725.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gper11 G protein-coupled estrogen receptor 1 71.2(n)
    71.52(a)
      565271  NM_001128723.1  NP_001122195.1 


    ENSEMBL Gene Tree for GPER1 (if available)
    TreeFam Gene Tree for GPER1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GPER1 gene
    GPR1462  
    5 SIMAP similar genes for GPER1 using alignment to 2 protein entries:     GPER1_HUMAN (see all proteins):
    GPER    GPR30    CCR1    CXCR1    CX3CR1

    Find genes that share paralogs with GPER1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    1 SNPs for GPER1    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs115443311,2,4
    ----see VAR_0333192 mis40--------

    HapMap Linkage Disequilibrium report for GPER1 (1121844 - 1133451 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for GPER1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GPER1
    DNA2.0 Custom Variant and Variant Library Synthesis for GPER1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601805    OMIM disorders: --

    2 diseases for GPER1:    
    About MalaCards
    pain disorder    breast cancer


    Find genes that share disorders with GPER1           About GenesLikeMe

    4 Novoseek inferred disease relationships for GPER1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 48.8 26 18467441 (3), 12027886 (2), 18768737 (2), 19342448 (2) (see all 12)
    ovarian cancer 22.1 3 17308128 (3), 19395996 (1)
    tumors 15.2 7 18467441 (2), 11043579 (1), 19951611 (1), 19749156 (1) (see all 5)
    cancer 0.465 5 19951611 (1), 19749156 (1), 17308128 (1), 19432902 (1)


    Export disorders for GPER1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GPER1 gene, integrated from 10 sources (see all 143):
    (articles sorted by number of sources associating them with GPER1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Discovery of three novel G-protein-coupled receptor genes. (PubMed id 9479505)1, 2, 3 O'Dowd B.F.... George S.R. (Genomics 1998)
    2. G protein-coupled receptor 30 expression is up-regulated by EGF and TGF alpha in estrogen receptor alpha-positive cancer cells. (PubMed id 19749156)1, 2, 9 Vivacqua A....Maggiolini M. (Mol. Endocrinol. 2009)
    3. Identification of a gene (GPR30) with homology to the G-protein- coupled receptor superfamily associated with estrogen receptor expression in breast cancer. (PubMed id 9367686)1, 2, 9 Carmeci C.... Weigel R.J. (Genomics 1997)
    4. Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans- activation of the epidermal growth factor receptor through release of HB-EGF. (PubMed id 11043579)1, 2, 9 Filardo E.J.... Frackelton A.R. Jr. (Mol. Endocrinol. 2000)
    5. Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. (PubMed id 15539556)1, 2, 9 Thomas P.... Dong J. (Endocrinology 2005)
    6. Coordinate regulation of estrogen-mediated fibronectin matrix assembly and epidermal growth factor receptor transactivation by the G protein-coupled receptor, GPR30. (PubMed id 19342448)1, 2, 9 Quinn J.A....Filardo E.J. (Mol. Endocrinol. 2009)
    7. Progestin upregulates G-protein-coupled receptor 30 in breast cancer cells. (PubMed id 12027886)1, 2, 9 Ahola T.M....Ylikomi T. (Eur. J. Biochem. 2002)
    8. G protein-coupled receptor 30 localizes to the endoplasmic reticulum and is not activated by estradiol. (PubMed id 18566127)1, 2, 9 Otto C....Fritzemeier K.H. (Endocrinology 2008)
    9. Minireview: G protein-coupled estrogen receptor-1, GPER-1: its mechanism of action and role in female reproductive cancer, renal and vascular physiology. (PubMed id 22495674)1, 2 Filardo E.J. and Thomas P. (Endocrinology 2012)
    10. G-protein coupled receptor 30 (GPR30): a novel regulator of endothelial inflammation. (PubMed id 23285008)1, 2 Chakrabarti S. and Davidge S.T. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2852 HGNC: 4485 AceView: GPR30 Ensembl:ENSG00000164850 euGenes: HUgn2852
    ECgene: GPER1 Kegg: 2852 H-InvDB: GPER1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GPER1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GPER1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GPER1 gene:
    Search GeneIP for patents involving GPER1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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