Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GPER1 Gene

protein-coding   GIFtS: 39
GCID: GC07P001122

G Protein-Coupled Estrogen Receptor 1

(Previous name: G protein-coupled receptor 30)
(Previous symbols: CMKRL2, GPR30, GPER)
  Search for GPER1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
G Protein-Coupled Estrogen Receptor 11 2     IL8-Related Receptor DRY122 3
CMKRL21 2 3 5     mER2 3
GPR301 2 3 5     GPCR-Br2
GPER1 2 5     LERGU2
G Protein-Coupled Receptor 301 2     LERGU22
Chemoattractant Receptor-Like 22 3     LyGPR2
Flow-Induced Endothelial G-Protein Coupled Receptor 12 3     Chemokine Receptor-Like 22
Lymphocyte-Derived G-Protein Coupled Receptor2 3     Constitutively Expressed Peptide-Like Receptor2
Membrane Estrogen Receptor2 3     G-Protein Coupled Estrogen Receptor 12
CEPR2 3     Heptahelix Receptor2
DRY122 3     Leucine Rich Protein In GPR30 3'UTR2
FEG-12 3     GPCR-BR3
G-Protein Coupled Receptor 302 3     LYGPR3

External Ids:    HGNC: 44851   Entrez Gene: 28522   Ensembl: ENSG000001648507   OMIM: 6018055   UniProtKB: Q995273   

Export aliases for GPER1 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GPER1 Gene:
This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that
localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium
mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore
plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues
with estrogen. Alternate transcriptional splice variants which encode the same protein have been characterized.
(provided by RefSeq, Jul 2008)

GeneCards Summary for GPER1 Gene: 
GPER1 (G protein-coupled estrogen receptor 1) is a protein-coding gene. Among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Development Endothelin-1/EDNRA signaling. An important paralog of this gene is GPR146.

UniProtKB/Swiss-Prot: GPER_HUMAN, Q99527
Function: Receptor for estrogen

summary for GPER1 Gene:
The GPR30 receptor is an orphan G-protein-coupled receptor that has recently been shown to bind estrogen and
cause estrogen-mediated adenylyl cyclase stimulation. GPR30 is widely distributed in neural, breast cancer,
placental, heart, ovarian, prostate, hepatic, vascular epithelial and lymphoid tissue. The receptor acts
independently of ERalpha and ERbeta and triggers ER-dependent EGFR action.

Gene Wiki entry for GPER1 (GPR30) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for GPER1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): GPER1 promoter sequence
   Search SABiosciences Chromatin IP Primers for GPER1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPER1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.3   Ensembl cytogenetic band:  7p22.3   HGNC cytogenetic band: 7p22

GPER1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPER1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P001122:  view genomic region     (about GC identifiers)

Start:
1,121,844 bp from pter      End:
1,133,451 bp from pter
Size:
11,608 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 1,180,870-1,187,850     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GPER_HUMAN, Q99527 (See protein sequence)
Recommended Name: G-protein coupled estrogen receptor 1  
Size: 375 amino acids; 42248 Da
Subcellular location: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass
membrane protein (By similarity). Golgi apparatus membrane; Multi-pass membrane protein (By similarity).
Note=Protein has been detected in the cell membrane, endoplasmic reticulum and Golgi apparatus. It is currently
unclear whether this is a cell surface or intracellular receptor
Secondary accessions: A8K6C5 B5BUJ1 O00143 O43494 Q13631 Q6FHL1 Q96F42 Q99981

Explore the universe of human proteins at neXtProt for GPER1: NX_Q99527

Explore proteomics data for GPER1 at MOPED 

GPER1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

GPER1 Protein Expression

REFSEQ proteins (3 alternative transcripts): 
NP_001035055.1  NP_001496.1  NP_001091671.1  

ENSEMBL proteins: 
 ENSP00000385151   ENSP00000410487   ENSP00000297469   ENSP00000380277   ENSP00000380281  
Reactome Protein details: Q99527
Human Recombinant Protein Products for GPER1: 
Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for GPER1
OriGene Custom MassSpec 
OriGene Custom Protein Services for GPER1
GenScript Custom Purified and Recombinant Proteins Services for GPER1
Novus Biologicals GPER1 Proteins
Novus Biologicals GPER1 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 5/28 cellular component terms (GO ID links to tree view) (see all 28):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000139Golgi membrane IEA--
GO:0005622intracellular ISS--
GO:0005634nucleus IDA--
GO:0005635nuclear envelope IDA15705806
GO:0005737cytoplasm ISS--

GPER1 for ontologies           About GeneDecksing



GPER1 Antibody Products: 
Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for GPER1 (GPER/GPR30)
Browse OriGene Antibodies
OriGene Custom Antibody Services for GPER1
GenScript Custom Superior Antibodies Services for GPER1
Novus Biologicals GPER1 Antibodies
Abcam antibodies for GPER1
Browse Antibodies at Cloud-Clone Corp. 
ThermoFisher Antibody for GPER1
Search LSBio for Antibodies for GPER1 

Assay Products for GPER1: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for GPER1
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for GPER1
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp. 
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
2 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q99527

ProtoNet protein and cluster: Q99527

UniProtKB/Swiss-Prot: GPER_HUMAN, Q99527
Similarity: Belongs to the G-protein coupled receptor 1 family


GPER1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: GPER_HUMAN, Q99527
Function: Receptor for estrogen

     Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003682chromatin binding IDA--
GO:0004930G-protein coupled receptor activity IEA--
GO:0005496steroid binding IDA15539556
GO:0005515protein binding IPI--
GO:0017082mineralocorticoid receptor activity ISS--
     
GPER1 for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for GPER1:
 Decreased G3BP1 protein expres  Increased cell death HMECs cel 

     11 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Gpr30):
 cardiovascular system  endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism 
 immune system  limbs/digits/tail  liver/biliary system  no phenotypic analysis  reproductive system 
 skeleton 

GPER1 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for GPER1: Gper1tm1Cwan Gper1tm1135.2Arte Gper1tm1.1Lmlf

   inGenious Targeting Laboratory - Custom generated mouse model solutions for GPER1 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GPER1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GPER1 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GPER1 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GPER1
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate GPER1
SwitchGear 3'UTR luciferase reporter plasmidGPER1 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for GPER1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GPER1

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for GPER1
Sirion Biotech Customized adenovirus for overexpression of GPER1

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for GPER1 (see all 19)
OriGene ORF clones in mouse, rat for GPER1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for GPER1
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for GPER1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPER1
Sirion Biotech Customized lentivirus for stable overexpression of GPER1 
                     Customized lentivirus expression plasmids for stable overexpression of GPER1 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for GPER1
Search LifeMap BioReagents cell lines for GPER1
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPER1


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for GPER1 About                                                                                                See pathways by source

SuperPathContained pathways About
1Class A/1 (Rhodopsin-like receptors)
GPCRs, Class A Rhodopsin-like0.41
2Development Endothelin-1/EDNRA signaling
Estrogen signaling pathway0.34
3Estrogen signaling pathway
Estrogen signaling pathway

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


2 BioSystems Pathways for GPER1
    Estrogen signaling pathway
GPCRs, Class A Rhodopsin-like

5/7        Reactome Pathways for GPER1 (see all 7)
    GPCR downstream signaling
Peptide ligand-binding receptors
Signal Transduction
Signaling by GPCR
G alpha (i) signalling events


1         Kegg Pathway  (Kegg details for GPER1):
    Estrogen signaling pathway


GPER1 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GPER1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/143 Interacting proteins for GPER1 (ENSP000002974694) via UniProtKB, MINT, STRING, and/or I2D (see all 143)
InteractantInteraction Details
GeneCardExternal ID(s)
ADCY2ENSP000003429524STRING: ENSP00000342952
ADRA2CENSP000003860694STRING: ENSP00000386069
CCR1ENSP000002961404STRING: ENSP00000296140
CCR3ENSP000003500034STRING: ENSP00000350003
CCR5ENSP000002923034STRING: ENSP00000292303
About this table

Gene Ontology (GO): 5/46 biological process terms (GO ID links to tree view) (see all 46):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001934positive regulation of protein phosphorylation ISS--
GO:0001956positive regulation of neurotransmitter secretion ISS--
GO:0002695negative regulation of leukocyte activation IDA--
GO:0007186G-protein coupled receptor signaling pathway TAS8920907
GO:0007204elevation of cytosolic calcium ion concentration ISS--

GPER1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

GPER1 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Compounds for GPER1 available from Tocris Bioscience    About this table
CompoundAction CAS #
G-36Selective GPR30 antagonist[1392487-51-2]
G-15High affinity and selective GPR30 antagonist[1161002-05-6]
G-1Potent and selective GPR30 agonist[881639-98-1]

6 Novoseek inferred chemical compound relationships for GPER1 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
estrogen 74.6 77 18467441 (5), 11043579 (4), 18420744 (4), 19749156 (4) (see all 27)
progestin 62.6 16 12193550 (8), 12446589 (2), 15539556 (1), 16289637 (1)
estradiol 48.4 1 18566127 (1)
steroid 44.2 7 20228382 (1), 17640985 (1), 18420744 (1), 15511221 (1) (see all 5)
progesterone 35 2 20228382 (1), 12193550 (1)
calcium 17.9 2 19131510 (1)

Search CenterWatch for drugs/clinical trials and news about GPER1 / GPER

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GPER1 gene (4 alternative transcripts): 
NM_001039966.1  NM_001505.2  NM_001031682.1  NM_001098201.1  

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000401670 ENST00000413368 ENST00000297469(uc010ksd.1) ENST00000397088(uc003skb.2)
ENST00000397092(uc003sjz.1 uc003ska.1)
miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GPER1
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate GPER1
SwitchGear 3'UTR luciferase reporter plasmidGPER1 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for GPER1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GPER1
Clone
Products:
     
OriGene clones in human, mouse for GPER1 (see all 19)
OriGene ORF clones in mouse, rat for GPER1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for GPER1
DNA2.0 Custom Codon Optimized Gene Synthesis Service for GPER1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPER1
Sirion Biotech Customized lentivirus for stable overexpression of GPER1 
                     Customized lentivirus expression plasmids for stable overexpression of GPER1 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for GPER1
OriGene qSTAR qPCR primer pairs in human, mouse for GPER1
Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat GPER1
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPER1
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPER1

24/75 AceView cDNA sequences (see all 75):

BX101291 BU857553 BU732605 BQ278731 BC082766 BU857973 CB106598 U63917 
Y08162 BX642222 BM725033 BF446164 CR541741 BC067849 BX360399 AY265807 
CF994734 CD671944 BE677759 AA748990 BC011634 BG338329 BG824221 AL521050 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GPER1 expression in normal human tissues (normalized intensities)      GPER1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
GPER1 Expression
About this image


GPER1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/34 selected tissues (see all 34) fully expand
 
 Testis (Reproductive System)    fully expand to see all 3 entries
         Leydig Cells Testis Interstitium
         seminal vesicle ; glandular cells   
 
 Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
         rectum ; glandular cells   
 
 Brain (Nervous System)    fully expand to see all 3 entries
         Cerebral Cortex
 
 Lung (Respiratory System)    fully expand to see all 3 entries
         lung ; pneumocytes   
 
 Blood (Hematopoietic System)    fully expand to see all 2 entries
         Hematopoietic Stem Cells Hematopoietic Bone Marrow
         lung ; macrophages   

See GPER1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GPER1

UniProtKB/Swiss-Prot: GPER_HUMAN, Q99527
Tissue specificity: Ubiquitously expressed, but is most abundant in placenta. In brain regions, expressed as a 2.8
kb transcript in basal forebrain, frontal cortex, thalamus, hippocampus, caudate and putamen

    SABiosciences Custom PCR Arrays for GPER1
Primer
Products:
OriGene qPCR primer pairs and template standards for GPER1
OriGene qSTAR qPCR primer pairs in human, mouse for GPER1
Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat GPER1
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPER1
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPER1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPER1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for GPER1 gene from 4/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Gpr301 , 5 G protein-coupled receptor 301, 5 84.53(n)1
86.93(a)1
  5 (78.58 cM)5
768541  NM_029771.31  NP_084047.21 
 1394231515 
chicken
(Gallus gallus)
Aves GPER1 G protein-coupled estrogen receptor 1 71.06(n)
77.59(a)
  416457  NM_001162405.1  NP_001155877.1 
lizard
(Anolis carolinensis)
Reptilia GPER6
Uncharacterized protein
78(a)
1 ↔ 1
GL343327.1(1445250-1446293)
zebrafish
(Danio rerio)
Actinopterygii gper1 G protein-coupled estrogen receptor 1 71.55(n)
71.97(a)
  565271  NM_001128723.1  NP_001122195.1 


ENSEMBL Gene Tree for GPER1 (if available)
TreeFam Gene Tree for GPER1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for GPER1 gene
GPR1462  

GPER1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing GPER1
DNA2.0 Custom Variant and Variant Library Synthesis for GPER1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

GPER1 for disorders           About MalaCards
OMIM gene information: 601805    OMIM disorders: --


GPER1 for disorders           About GeneDecksing

4 Novoseek inferred disease relationships for GPER1 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer 48.8 26 18467441 (3), 12027886 (2), 18768737 (2), 19342448 (2) (see all 12)
ovarian cancer 22.1 3 17308128 (3), 19395996 (1)
tumors 15.2 7 18467441 (2), 11043579 (1), 19951611 (1), 19749156 (1) (see all 5)
cancer 0.465 5 19951611 (1), 19749156 (1), 17308128 (1), 19432902 (1)


Export disorders for GPER1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for GPER1 gene, integrated from 9 sources (see all 125):
(articles sorted by number of sources associating them with GPER1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Discovery of three novel G-protein-coupled receptor genes. (PubMed id 9479505)1, 2, 3 O'Dowd B.F.... George S.R. (1998)
  2. Identification of a gene (GPR30) with homology to the G-protein- coupled receptor superfamily associated with estrogen receptor expression in breast cancer. (PubMed id 9367686)1, 2, 9 Carmeci C.... Weigel R.J. (1997)
  3. Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans- activation of the epidermal growth factor receptor through release of HB-EGF. (PubMed id 11043579)1, 2, 9 Filardo E.J.... Frackelton A.R. Jr. (2000)
  4. Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. (PubMed id 15539556)1, 2, 9 Thomas P.... Dong J. (2005)
  5. Synthetic estrogen derivatives demonstrate the functionality of intracellular GPR30. (PubMed id 17655271)1, 3 Revankar C.M....Prossnitz E.R. (2007)
  6. A transmembrane intracellular estrogen receptor mediates rapid cell signaling. (PubMed id 15705806)1, 2 Revankar C.M....Prossnitz E.R. (2005)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  8. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
  9. Cloning of cDNAs encoding G protein-coupled receptor expressed in human endothelial cells exposed to fluid shear stress. (PubMed id 9398636)1, 2 Takada Y.... Ando J. (1997)
  10. A novel putative G-protein-coupled receptor expressed in lung, heart and lymphoid tissue. (PubMed id 9141481)1, 2 Kvingedal A.M. and Smeland E.B. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 2852 HGNC: 4485 AceView: GPR30 Ensembl:ENSG00000164850 euGenes: HUgn2852
ECgene: GPER1 Kegg: 2852 H-InvDB: GPER1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for GPER1 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for GPER1 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for GPER1 gene:
Search GeneIP for patents involving GPER1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
 EMD Millipore Custom Antibody & Bulk Services
 EMD Millipore Preclinical / Clinical Development Services
 EMD Millipore Immunoassay Services
 EMD Millipore Target Screening & Profiling Services

  
 Antibodies for GPER1 (GPER/GPR30)   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
 Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
 Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
 cDNA Clones for GPER1 (GPER/GPR30)   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for GPER1  
 OriGene qPCR primer pairs and template standards for GPER1   OriGene Protein Over-expression Lysate for GPER1  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for GPER1  
 OriGene qSTAR qPCR primer pairs in human, mouse for GPER1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for GPER1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for GPER1   OriGene Custom Protein Services for GPER1  

 
 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GPER1
 QIAGEN SeqTarget long-range PCR primers for resequencing GPER1
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPER1
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GPER1
 QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPER1
 QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GPER1
 GenScript Custom Purified and Recombinant Proteins Services for GPER1 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for GPER1
 GenScript Custom Assay Services for GPER1 GenScript Custom Superior Antibodies Services for GPER1
 GenScript Custom overexpressing Cell Line Services for GPER1 CloneReady with Over 120,000 Genes
 Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
 Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
 Custom Peptide Services
 Search for Antibodies & Assays

 Search Regulatory tfbs for GPER1
 Search Chromatin IP Primers for GPER1
 Search RT2 qPCR Primer Assays in human, mouse, rat GPER1
 Search GNC Networks for GPER1
 SABiosciences Custom PCR Arrays for GPER1
 Tocris compounds for GPER1
 Browse Sino Biological Proteins and Antibodies
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
 GPER1 antibodies
 GPER1 proteins
 GPER1 lysates
 Antibodies for GPER1
 See all of Abcam's Antibodies, Kits and Proteins for GPER1
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins




 Browse Proteins at Cloud-Clone Corp.
 Browse Antibodies at Cloud-Clone Corp.
 Browse ELISAs at Cloud-Clone Corp.
 Browse CLIAs at Cloud-Clone Corp.
 Search LifeMap BioReagents cell lines for GPER1
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPER1
 SwitchGear 3'UTR luciferase reporter plasmids for GPER1
 SwitchGear Promoter luciferase reporter plasmids for GPER1
 ThermoFisher Antibody for GPER1
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPER1
 inGenious Targeting Laboratory - Custom generated mouse model solutions for GPER1
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GPER1
Customized:
 lentivirus for stable overexpression of GPER1
 lentivirus expression plasmids for stable overexpression of GPER1
 adenovirus for overexpression of GPER1
 Search LSBio for Antibodies for GPER1
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category
(GIFtS: 73)
transforming growth factor, beta 1
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      GPER1 gene at Home site.
hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4