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GPER Gene

protein-coding   GIFtS: 49

GC07P001093
G protein-coupled estrogen receptor 1
(Previous name: G protein-coupled receptor 30 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: CMKRL2, GPR30)
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Aliases &
Descriptions
for GPER

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
CEPR 1, 2, 3
CMKRL2 2, 3
DRY12 1, 2, 3
FEG-1 1, 2, 3
GPCR-BR 3
GPCR-Br 1, 2
GPR30 2, 3
LERGU 1, 2
LERGU2 1, 2
LYGPR 3
LyGPR 1, 2
MGC99678 2
OTTHUMP00000115502 2
mER 3
Descriptions
Chemokine receptor-like 2 2, 3
Flow-induced endothelial G-protein coupled receptor 1 3
G protein-coupled estrogen receptor 1 2
G protein-coupled receptor 30 1, 2
G-protein coupled receptor 30 3
IL8-related receptor 2
IL8-related receptor DRY12 3
Lymphocyte-derived G-protein coupled receptor 3
Membrane estrogen receptor 3
constitutively expressed peptide-like receptor 2
flow-induced endothelial G-protein coupled receptor 2
heptahelix receptor 2
leucine rich protein in GPR30 3'UTR 2
External Ids
HGNC: 44851
Entrez Gene: 28522
UniProtKB: Q995273
Ensembl: ENSG000001648507
Search outside databases for aliases for GPER gene

Summaries
for GPER

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for GPER:
This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane
protein that localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in
intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in
the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely
observed following stimulation of cells and tissues with estrogen. Alternate transcriptional
splice variants which encode the same protein have been characterized. [provided by RefSeq]

UniProtKB/Swiss-Prot: GPER_HUMAN, Q99527
Function: Receptor for estrogen

Gene Wiki entry for GPER (GPR30)

Genomic Location
for GPER

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.3   Ensembl cytogenetic band:  7p22.3   HGNC cytogenetic band: 7p22

GPER Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P001093:     (about GC identifiers)

Start:
 1,088,370 bp from pter
End:
 1,099,977 bp from pter
Size:
 11,608 bases
Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 1,180,870-1,187,850     
RefSeq DNA sequence:
NC_000007.12  NT_007819.16  NT_079592.2  

Proteins
for GPER

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: GPER_HUMAN, Q99527 (See protein sequence)
Recommended Name: G-protein coupled estrogen receptor 1  
Size: 375 amino acids; 42248 Da
Subcellular location: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane;
Multi-pass membrane protein (By similarity). Golgi apparatus membrane; Multi-pass membrane protein
(By similarity). Note=Protein has been detected in the cell membrane, endoplasmic reticulum and
Golgi apparatus. It is currently unclear whether this is a cell surface or intracellular receptor
Secondary accessions: B5BUJ1 O00143 O43494 Q13631 Q6FHL1 Q96F42 Q99981

REFSEQ proteins (3 alternative transcripts): 
NP_001035055.1  NP_001091671.1  NP_001496.1  


ENSEMBL proteins: 
ENSP00000341512 ENSP00000385151 ENSP00000380281 ENSP00000297469 ENSP00000380277 ENSP00000346586 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (GPCR GPR30)
Human Recombinant Proteins from Abnova (GPR30)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO IDQualified GO termEvidencePubMed IDs
GO:0000139 Golgi membrane IEA--
GO:0005783 endoplasmic reticulum IEA--
GO:0005789 endoplasmic reticulum membrane IEA--
GO:0005794 Golgi apparatus IEA--
GO:0005886 plasma membrane IEA--
About this table

Antibodies for GPER: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
R&D Systems Antibodies for GPER
Antibodies from Abcam (GPCR GPR30), each with their AbpromiseSM
Browse Abnova for Monoclonal and Polyclonal Antibodies
Novus Biologicals Antibodies for GPER

Assays for GPER: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for GPER

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
3 InterPro domains/families:
 IPR017452 GPCR_Rhodpsn_supfam
 IPR015692 GPR30
 IPR000276 7TM_GPCR_Rhodpsn


   GeneDecks  GPER for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q99527

ProtoNet protein and cluster: Q99527

UniProtKB/Swiss-Prot: GPER_HUMAN, Q99527
Similarity: Belongs to the G-protein coupled receptor 1 family

Gene Function
for GPER

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (GPER)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (GPR30)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001098201

              Applied Biosystems Silencer® siRNAs for GPER

              Sigma-Aldrich siRNA and siRNA Panels for GPER  
                     Sigma-Aldrich shRNA Panels and shRNA for GPER  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for GPER
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001039966
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001039966
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001039966 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001031682

UniProtKB/Swiss-Prot: GPER_HUMAN, Q99527
Function: Receptor for estrogen

10 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Gper):

digestive/alimentaryendocrine/exocrine glandgrowth/sizehomeostasis/metabolism
limbs/digits/tailliver/biliary systemno phenotypic analysisreproductive systemskeleton

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0004872 receptor activity IEA--
GO:0004930 G-protein coupled receptor activity TAS8920907
About this table

Pathways & Interactions
for GPER

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


1 Sigma-Aldrich "Your Favorite Gene" Pathway for  GPER  (Your Favorite Gene powered by Ingenuity) 
 G-Protein Coupled Receptor Signaling

   GeneDecks  GPER for the pathways selected above  
About GeneDecksing

 Gene Network CentralTM Interacting Genes and Proteins Network for  GPER 


5 Interacting proteins for GPER (ENSP000003465863) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
TFAP2CENSP000002010313STRING (score=.906)
NCOA2ENSP000002679743STRING (score=.897)
ESR1ENSP000002062493STRING (score=.83)
ESR2ENSP000003439253STRING (score=.744)
MERTKENSP000002954083STRING (score=.74)
About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0007165 signal transduction IEA--
GO:0007186 G-protein coupled receptor protein signaling pathway TAS8920907
About this table

Drugs & Compounds
for GPER

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Sigma-Aldrich Small Molecules for GPER:
Mixed Agonist/Antagonist

Compounds for GPER available from Tocris Bioscience
CompoundAction CAS number
beta-EstradiolEndogenous ER agonist[50-28-2]
Tamoxifen citrateEstrogen receptor partial agonist/antagonist[54965-24-1]
ICI 182,780Estrogen receptor antagonist[129453-61-8]
About this table


4 Novoseek chemical compound relationships for GPER gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
estradiol 46.12 1 18566127 (1)
progesterone 35.61 1 12193550 (1)
steroid 35.48 6 17640985 (1), 18420744 (1), 15511221 (1), 16289637 (1)
calcium 24.50 2 19131510 (1)
About this table


Transcripts
for GPER

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (GPER)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (GPR30)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001098201

              Sigma-Aldrich siRNA and siRNA Panels for GPER  
                     Sigma-Aldrich shRNA Panels and shRNA for GPER  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001039966  NM_001098201  NM_001505  

REFSEQ mRNAs for GPER gene (3 alternative transcripts): 

NM_001039966.1   NM_001098201.1   NM_001505.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001039966  NM_001098201  NM_001505  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001039966
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001039966
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001039966 

Additional cDNA sequence: 

AB451427.1 AF015257.1 AK289588.1 AY265807.1 AY265808.1 AY265809.1 BC011634.1 BC067849.1 
BC082766.1 CR541655.1 CR541741.1 U58828.1 U63917.1 X98510.1 Y08162.1 

6 DOTS entries:

DT.100691243  DT.101963730  DT.95371254  DT.112109  DT.91758727  DT.100790769 

24/75 AceView cDNA sequences (see all 75 ):

BQ278731 BU857553 BC082766 BX101291 Y08162 BU732605 CB106598 U63917 
BU857973 BE677759 CB987997 AL521050 X98510 AI432432 BC011634 CD671944 
AF015257 CR541655 AY265809 CF994734 AY265807 BM680243 BF446164 CB991744 

Unigene Cluster for GPER:

G protein-coupled estrogen receptor 1
Hs.20961  [show with all ESTs]
Unigene Representative Sequence: NM_001039966


GeneLoc Exon Structure

6 Ensembl transcripts including schematic representations:
ENST00000342452  ENST00000401670  ENST00000397092  ENST00000297469  ENST00000397088  ENST00000354575  

Expression
for GPER

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

GPER expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for GPER

1 / 2

5 probe-sets matching GPER gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
37447_at2 U95-A 1 1.00 1.00 1.00 1.00 -- -- -- -- --

210640_s_at2 U133-A 1 1.00 1.00 -- -- -- -- -- -- --

211829_s_at2 U133-A 1 1.00 1.00 -- -- -- -- -- -- --

210640_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

211829_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  GPER for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: TGCGGAAAAA

SOURCE GeneReport for Unigene cluster: Hs.20961

UniProtKB/Swiss-Prot: GPER_HUMAN, Q99527
Tissue specificity: Ubiquitously expressed, but is most abundant in placenta. In brain regions,
expressed as a 2.8 kb transcript in basal forebrain, frontal cortex, thalamus, hippocampus,
caudate and putamen

Orthologs
for GPER

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for GPER gene from 5/7 species (see all 7 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 GPER1   -- G protein-coupled estrogen receptor 1 86.49(n)
89.73(a)		 480808  XM_537923.2  XP_537923.2 
chimpanzee
(Pan troglodytes)		 GPER1   -- G protein-coupled estrogen receptor 1 99.47(n)
100(a)		 463215  XM_001145483.1  XP_001145483.1 
cow
(Bos taurus)		 GPER1   -- G protein-coupled estrogen receptor 1 84.95(n)
84.29(a)		 527831  XM_606236.3  XP_606236.3 
rat
(Rattus norvegicus)		 Gper1   -- G protein-coupled estrogen receptor 1 84(n)
86.13(a)		 171104  NM_133573.1  NP_598257.1 
mouse
(Mus musculus)		 Gper1, 5 55
 G protein-coupled estrogen receptor 11, 5 84.44(n)1
86.67(a)1		 768541  NM_029771.21  NP_084047.11 
 AK0182035  AK0303755  (see all 7)
About this table        Species with no ortholog for GPER

ENSEMBL Gene Tree for GPER

Paralogs
for GPER

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for GPER gene
GPR1462  

SNPs/Variants
for GPER

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

  --

Disorders & Mutations
for GPER

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

 OMIM: 601805

4 Novoseek disease relationships for GPER gene

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer 45.33 19 18467441 (3), 12027886 (2), 18768737 (2), 12193550 (2) (see all 9)
ovarian cancer 28.79 3 17308128 (3), 19395996 (1)
tumors 17.34 5 18467441 (2), 11043579 (1), 9367686 (1)
cancer 0.00 2 17308128 (1)
About this table

Medical News
for GPER

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for GPER

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/60 PubMed articles for GPER gene (see all 60 ):

Search for GPER

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing GPER

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 2852 HGNC: 4485 AceView: GPR30 Ensembl:ENSG00000164850 euGenes: HUgn2852
ECgene: GPER H-InvDB: GPER

Other Databases showing GPER

(According to HUGE)
About This Section

   --

Specialized Databases showing GPER

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for GPER

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for GPER

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for GPER:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for GPER-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for GPER Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for GPER Small molecules for GPER
 "Your Favorite Gene" Pathwaysfeedback


  
 Antibodies   Primer Pairs  
 Cell Culture Products   ELISAs  
 Flow Cytometry Kits   Protease Activity Assays & Reagents  
 Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
 Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
 Recombinant & Natural Proteins  

 Recombinant Proteins (GPR30)
 Search for Antibodies
 Chimera RNAi (GPR30)
 Custom Service for Mouse Mab
 Custom Service for Rabbit Pab from Full-length Protein
  
 Search for Antibodies & Assays

 Recombinant Proteins
(GPCR GPR30)
 Antibodies (GPCR GPR30)
 Search OriGene for GPER
 Tocris compounds for GPER




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for GPER

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