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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GPER Gene

protein-coding GIFtS: 56
GCID: GC07P001121

G protein-coupled estrogen receptor 1

(Previous name: G protein-coupled receptor 30 )
(Previous symbols: CMKRL2, GPR30)

Explore 25 diseases affiliated with
GPER via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
G Protein-Coupled Estrogen Receptor 1¹ ²		Lymphocyte-Derived G-Protein Coupled Receptor² ³
CMKRL2¹ ² ³ ⁵		Membrane Estrogen Receptor² ³
GPR30¹ ² ³ ⁵		G-Protein Coupled Receptor 30² ³
CEPR¹ ² ³		IL8-Related Receptor DRY12² ³
DRY12¹ ² ³		MER¹
FEG-1¹ ² ³		Chemokine Receptor-Like 2²
GPCR-Br¹ ²		Constitutively Expressed Peptide-Like Receptor²
LERGU¹ ²		G-Protein Coupled Estrogen Receptor 1²
LERGU2¹ ²		Heptahelix Receptor²
LyGPR¹ ²		Leucine Rich Protein In GPR30 3'UTR²
G Protein-Coupled Receptor 30¹ ²		GPCR-BR³
Chemoattractant Receptor-Like 2² ³		LYGPR³
Flow-Induced Endothelial G-Protein Coupled Receptor 1² ³

External Ids:	HGNC: 4485¹	Entrez Gene: 2852²	Ensembl: ENSG00000164850⁷	OMIM: 601805⁵	UniProtKB: Q99527³

Export aliases for GPER gene to outside databases

Previous GC identifers: GC07P001093 GC07P001041

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GPER:

This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that

localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilization

and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the

rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternate

transcriptional splice variants which encode the same protein have been characterized. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: GPER_HUMAN, Q99527

Function: Receptor for estrogen

summary for GPER:

The GPR30 receptor is an orphan G-protein-coupled receptor that has recently been shown to bind estrogen and

cause estrogen-mediated adenylyl cyclase stimulation. GPR30 is widely distributed in neural, breast cancer,

placental, heart, ovarian, prostate, hepatic, vascular epithelial and lymphoid tissue. The receptor acts

independently of ERalpha and ERbeta and triggers ER-dependent EGFR action.

Gene Wiki entry for GPER (GPR30)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GPER gene promoter:
CREB deltaCREB
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): GPER promoter sequence

Search SABiosciences Chromatin IP Primers for GPER

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPER

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.3 Ensembl cytogenetic band: 7p22.3 HGNC cytogenetic band: 7p22

GPER Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPER gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P001121: view genomic region (about GC identifiers)

Start:	1,121,844 bp from pter	End:	1,133,451 bp from pter
Size:	11,608 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 1,180,870-1,187,850

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GPER_HUMAN, Q99527 (See protein sequence)

Recommended Name: G-protein coupled estrogen receptor 1

Size: 375 amino acids; 42248 Da

Subcellular location: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane

protein (By similarity). Golgi apparatus membrane; Multi-pass membrane protein (By similarity). Note=Protein has been

detected in the cell membrane, endoplasmic reticulum and Golgi apparatus. It is currently unclear whether this is a

cell surface or intracellular receptor

Secondary accessions: A8K6C5 B5BUJ1 O00143 O43494 Q13631 Q6FHL1 Q96F42 Q99981

Explore the universe of human proteins at neXtProt for GPER: NX_Q99527

GPER Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001035055.1 NP_001496.1 NP_001091671.1

ENSEMBL proteins:

ENSP00000385151 ENSP00000410487 ENSP00000297469 ENSP00000380277 ENSP00000380281

Reactome Protein details: Q99527
Human Recombinant Protein Products:

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	Uscn Proteins for GPER

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	IEA	--
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	8920907

GPER for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GPER for domains About GeneDecksing

2 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_7TM

IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q99527

ProtoNet protein and cluster: Q99527

UniProtKB/Swiss-Prot: GPER_HUMAN, Q99527

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: GPER_HUMAN, Q99527

Function: Receptor for estrogen

miRNA Products:		OriGene 3'-UTR Clone (see all 3): GPER Browse MicroRNA Expression Plasmids
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPER

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003707	steroid hormone receptor activity	--	--
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0005496	steroid binding	--	--
GO:0042562	hormone binding	--	--

GPER for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for GPER:

Decreased G3BP1 protein expres

Increased cell death HMECs cel

Animal Models:
Mouse knock-outs for GPER: Gpr30^tm1Cwan Gpr30^tm1135.2Arte Gpr30^tm1.1Lmlf
11 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Gpr30):

cardiovascular system	endocrine/exocrine gland	growth/size	hematopoietic system	homeostasis/metabolism
immune system	limbs/digits/tail	liver/biliary system	no phenotypic analysis	reproductive system
skeleton

GPER for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

Class A/1 (Rhodopsin-like receptors)	1.00	G alpha (i) signalling events	0.44
GPCR ligand binding	0.75	GPCRs, Class A Rhodopsin-like	0.41
Peptide ligand-binding receptors	0.61

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Estrogen signaling pathway

Estrogen signaling pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 BioSystems Pathways for GPER

	Estrogen signaling pathway
	GPCRs, Class A Rhodopsin-like

5/7 Reactome Pathways for GPER (see all 7)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Signal Transduction
	Signaling by GPCR
	G alpha (i) signalling events

GPER for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for GPER

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/143 Interacting proteins for GPER (ENSP00000297469⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 143)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ADCY2	ENSP00000342952⁴	STRING: ENSP00000342952
ADRA2C	ENSP00000386069⁴	STRING: ENSP00000386069
CCR1	ENSP00000296140⁴	STRING: ENSP00000296140
CCR3	ENSP00000350003⁴	STRING: ENSP00000350003
CCR5	ENSP00000292303⁴	STRING: ENSP00000292303

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007186	G-protein coupled receptor signaling pathway	TAS	8920907
GO:0030518	intracellular steroid hormone receptor signaling pathway	--	--
GO:0043401	steroid hormone mediated signaling pathway	--	--
GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	--	--
GO:0070374	positive regulation of ERK1 and ERK2 cascade	--	--

GPER for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

GPER for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for GPER available from Tocris Bioscience About this table

Compound	Action	CAS #
beta-Estradiol	Endogenous ER agonist	[50-28-2]
Tamoxifen citrate	Estrogen receptor partial agonist/antagonist	[54965-24-1]
ICI 182,780	Estrogen receptor antagonist	[129453-61-8]
G-15	High affinity and selective GPR30 antagonist	[1161002-05-6]

6 Novoseek chemical compound relationships for GPER gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
estrogen	74.6	77	18467441 (5), 11043579 (4), 18420744 (4), 19749156 (4) (see all 27)
progestin	62.6	16	12193550 (8), 12446589 (2), 15539556 (1), 16289637 (1)
estradiol	48.4	1	18566127 (1)
steroid	44.2	7	20228382 (1), 17640985 (1), 18420744 (1), 15511221 (1) (see all 5)
progesterone	35	2	20228382 (1), 12193550 (1)
calcium	17.9	2	19131510 (1)

Search CenterWatch for drugs/clinical trials and news about GPER

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GPER gene (4 alternative transcripts):

NM_001039966.1 NM_001505.2 NM_001031682.1 NM_001098201.1

Unigene Cluster for GPER:

G protein-coupled estrogen receptor 1

Hs.20961 [show with all ESTs]

Unigene Representative Sequence: NM_001039966

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000401670 ENST00000413368 ENST00000297469(uc010ksd.1) ENST00000397088(uc003skb.2)

ENST00000397092(uc003sjz.1 uc003ska.1)

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GPER

Additional cDNA sequence:

AB451427.1 AF015257.1 AK289588.1 AY265807.1 AY265808.1 AY265809.1 BC011634.1 BC067849.1

BC082766.1 CR541655.1 CR541741.1 U58828.1 U63917.1 X98510.1 Y08162.1

6 DOTS entries:

DT.100691243 DT.101963730 DT.112109 DT.95371254 DT.91758727 DT.100790769

24/75 AceView cDNA sequences (see all 75):

BX101291 CB106598 BC082766 U63917 BU732605 BU857973 Y08162 BU857553

BQ278731 CF994734 AI432432 BG338329 BI259114 BM680243 BX360399 AY265807

BX642222 BF224421 BP359982 CR541655 X98510 CD671944 BE677759 BF941220

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GPER expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCGGAAAAA

About this image

GPER expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)

Lateral Plate Mesoderm, Neural Crest

PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See GPER Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GPER

SOURCE GeneReport for Unigene cluster: Hs.20961

UniProtKB/Swiss-Prot: GPER_HUMAN, Q99527

Tissue specificity: Ubiquitously expressed, but is most abundant in placenta. In brain regions, expressed as a 2.8 kb

transcript in basal forebrain, frontal cortex, thalamus, hippocampus, caudate and putamen

SABiosciences Expression via Pathway-Focused PCR Arrays including GPER:

G Protein Coupled Receptors 384HT in human mouse rat

Estrogen Receptor Signaling in human mouse rat

Nuclear Receptors & Coregulators in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPER

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for GPER gene from 4/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Gpr30^{1 , 5}	G protein-coupled receptor 30^{1, 5}	84.53(n)¹ 86.93(a)¹		5 (78.58 cM)⁵ 76854¹ NM_029771.3¹ NP_084047.2¹ 139423151⁵
chicken (Gallus gallus)	Aves	GPER¹	G protein-coupled estrogen receptor 1	71.06(n) 77.59(a)		416457 NM_001162405.1 NP_001155877.1
lizard (Anolis carolinensis)	Reptilia	GPER⁶	--	78(a)	1 ↔ 1	GL343327.1(1445250-1446293)
zebrafish (Danio rerio)	Actinopterygii	gper¹	G protein-coupled estrogen receptor 1	71.55(n) 71.97(a)		565271 NM_001128723.1 NP_001122195.1

ENSEMBL Gene Tree for GPER (if available)
TreeFam Gene Tree for GPER (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GPER gene

GPR146²

5 SIMAP similar genes for GPER using alignment to 3 protein entries: GPER_HUMAN (see all proteins):

GPR30 CCR1 CMKLR1 CXCR1 CX3CR1

GPER for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs114604974^1,2	F,	--	1124473(+)	`ACGGCG/AACATG`	5	--	int¹ us2k¹		1		WA	118
rs184534346^1,2		--	1124535(+)	`CCTACC/TATGGA`	5	--	int¹ us2k¹		0	--	--	--	--
rs143483318^1,2		--	1124656(+)	`GGCCTC/TTCAGC`	5	--	int¹ us2k¹		0	--	--	--	--
rs3808349^1,2	C,F,	--	1124694(+)	`CTGAAG/AGGTCA`	5	--	int¹ us2k¹		1		EA	1494
rs73670157^1,2	C,F,	--	1124697(+)	`AAGGGT/GCAAAG`	5	--	int¹ us2k¹		4		WA NA	124
rs73670158^1,2	C,F,	--	1124737(+)	`CACTCG/AGGAGG`	5	--	us2k¹ int¹		4		WA NA	124
rs143378541^1,2		--	1124822(+)	`TGTGCA/GTTTAG`	5	--	us2k¹ int¹		0	--	--	--	--
rs75515957^1,2	C,F,	--	1124986(+)	`CAGGAC/TGCCTC`	5	--	int¹ us2k¹		2		NA EA	240
rs180763616^1,2		--	1125154(+)	`AGGGTA/GACCTA`	5	--	int¹ us2k¹		0	--	--	--	--
rs116567372^1,2	F,	--	1125171(+)	`AGCACG/ACAGAG`	5	--	int¹ us2k¹		1		WA	118

HapMap Linkage Disequilibrium report for GPER (1121844 - 1133451 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for GPER
2 CNVs: 0093 4519

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GPER

DNA2.0 Custom Variant and Variant Library Synthesis for GPER

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

GPER for disorders           About GeneDecksing

OMIM gene information: 601805    OMIM disorders: --

20/25 diseases for GPER (see all 25):    About MalaCards

breast cancer estrogen-receptor negative breast cancer estrogen-receptor positive breast cancer hepatitis

prostatitis gonorrhea polycystic ovary syndrome pain disorder

burkitt's lymphoma inflammatory breast cancer ovarian cancer pharyngitis

endometrial carcinoma endometrial cancer thyroid cancer gastric cancer

blindness breast carcinoma thyroiditis carcinoma

1 disease from the University of Copenhagen DISEASES database for GPER:

Breast cancer

4 Novoseek disease relationships for GPER gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer	48.8	26	18467441 (3), 12027886 (2), 18768737 (2), 19342448 (2) (see all 12)
ovarian cancer	22.1	3	17308128 (3), 19395996 (1)
tumors	15.2	7	18467441 (2), 11043579 (1), 19951611 (1), 19749156 (1) (see all 5)
cancer	0.465	5	19951611 (1), 19749156 (1), 17308128 (1), 19432902 (1)

Human Genome Epidemiology (HuGE) Navigator: GPER (2 documents)

Export disorders for GPER gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for GPER gene, integrated from 9 sources (see all 116):
(articles sorted by number of sources associating them with GPER)

Utopia: connect your pdf to the dynamic
world of online information

Discovery of three novel G-protein-coupled receptor genes. (PubMed id 9479505)^{1, 2, 3} O'Dowd B.F.... George S.R. (1998)
Identification of a gene (GPR30) with homology to the G-protein- coupled receptor superfamily associated with estrogen receptor expression in breast cancer. (PubMed id 9367686)^{1, 2, 9} Carmeci C.... Weigel R.J. (1997)
Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans- activation of the epidermal growth factor receptor through release of HB-EGF. (PubMed id 11043579)^{1, 2, 9} Filardo E.J.... Frackelton A.R. Jr. (2000)
Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. (PubMed id 15539556)^{1, 2, 9} Thomas P.... Dong J. (2005)
Synthetic estrogen derivatives demonstrate the functionality of intracellular GPR30. (PubMed id 17655271)^{1, 3} Revankar C.M....Prossnitz E.R. (2007)
A transmembrane intracellular estrogen receptor mediates rapid cell signaling. (PubMed id 15705806)^{1, 2} Revankar C.M....Prossnitz E.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)^{1, 2} Scherer S.W.... Tsui L.-C. (2003)
Cloning of cDNAs encoding G protein-coupled receptor expressed in human endothelial cells exposed to fluid shear stress. (PubMed id 9398636)^{1, 2} Takada Y.... Ando J. (1997)
A novel putative G-protein-coupled receptor expressed in lung, heart and lymphoid tissue. (PubMed id 9141481)^{1, 2} Kvingedal A.M. and Smeland E.B. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2852	HGNC: 4485	AceView: GPR30	Ensembl:ENSG00000164850	euGenes: HUgn2852
ECgene: GPER	H-InvDB: GPER

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for GPER	Pharmacogenomics, SNPs, Pathways

Intellectual Property for GPER gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for GPER gene:
Search GeneIP for patents involving GPER

GeneCards and IP:
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G protein-coupled estrogen receptor 1

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GPER (Gene Symbol)
G Protein-Coupled Estrogen Receptor 1
CMKRL2
GPR30
CEPR
DRY12
FEG-1
GPCR-Br
LERGU
LERGU2
LyGPR
G Protein-Coupled Receptor 30
Chemoattractant Receptor-Like 2
Flow-Induced Endothelial G-Protein Coupled Receptor 1
Lymphocyte-Derived G-Protein Coupled Receptor
Membrane Estrogen Receptor
G-Protein Coupled Receptor 30
IL8-Related Receptor DRY12
MER
Chemokine Receptor-Like 2
Constitutively Expressed Peptide-Like Receptor
G-Protein Coupled Estrogen Receptor 1
Heptahelix Receptor
Leucine Rich Protein In GPR30 3'UTR
GPCR-BR
LYGPR

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GPER Gene

G protein-coupled estrogen receptor 1

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