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GPD1 Gene(Protein Coding)

Glycerol-3-Phosphate Dehydrogenase 1

GCID:
GC12P050105
GIFtS:
67
Genes Participants
UDN Logo

Aliases for GPD1 Gene

Aliases for GPD1 Gene

  • Glycerol-3-Phosphate Dehydrogenase 1 2 3 5
  • Glycerol-3-Phosphate Dehydrogenase 1 (Soluble) 2 3
  • EC 1.1.1.8 4 63
  • GPDH-C 3 4
  • GPD-C 3 4
  • Glycerol-3-Phosphate Dehydrogenase [NAD+], Cytoplasmic 3
  • Glycerophosphate Dehydrogenase 3
  • EC 1.1.1 63
  • HTGTI 3

External Ids for GPD1 Gene

Previous GeneCards Identifiers for GPD1 Gene

  • GC12P050792
  • GC12P050553
  • GC12P050214
  • GC12P048784
  • GC12P050497
  • GC12P047531

Summaries for GPD1 Gene

Entrez Gene Summary for GPD1 Gene

  • This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria. Mutations in this gene are a cause of transient infantile hypertriglyceridemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

GeneCards Summary for GPD1 Gene

GPD1 (Glycerol-3-Phosphate Dehydrogenase 1) is a Protein Coding gene. Diseases associated with GPD1 include Hypertriglyceridemia, Transient Infantile and Transient Infantile Hypertriglyceridemia And Hepatosteatosis. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Metabolism. GO annotations related to this gene include protein homodimerization activity and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. An important paralog of this gene is GPD1L.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPD1 Gene

Genomics for GPD1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for GPD1 Gene

Enhancers for GPD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPD1 on UCSC Golden Path with GeneCards custom track

Promoters for GPD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPD1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the GPD1 gene promoter:

Genomic Location for GPD1 Gene

Chromosome:
12
Start:
50,103,819 bp from pter
End:
50,111,320 bp from pter
Size:
7,502 bases
Orientation:
Plus strand

Genomic View for GPD1 Gene

Genes around GPD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPD1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GPD1 Gene

Proteins for GPD1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for GPD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21695-GPDA_HUMAN
    Recommended name:
    Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
    Protein Accession:
    P21695
    Secondary Accessions:
    • F8W1L5
    • Q8N1B0

    Protein attributes for GPD1 Gene

    Size:
    349 amino acids
    Molecular mass:
    37568 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for GPD1 Gene

    Alternative splice isoforms for GPD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPD1 Gene

Proteomics data for GPD1 Gene at MOPED

Protein Expression for GPD1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for GPD1 Gene

P21695:

Post-translational modifications for GPD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GPD1 Gene

Protein Domains for GPD1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GPD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P21695

UniProtKB/Swiss-Prot:

GPDA_HUMAN :
  • Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
Family:
  • Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
genes like me logo Genes that share domains with GPD1: view

No data available for Gene Families for GPD1 Gene

Function for GPD1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for GPD1 Gene

GENATLAS Biochemistry:
glycerol-3-phosphate dehydrogenase,NAD dependent,cytoplasmic
UniProtKB/Swiss-Prot CatalyticActivity:
sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by zinc ions and sulfate.

Enzyme Numbers (IUBMB) for GPD1 Gene

Gene Ontology (GO) - Molecular Function for GPD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004368 glycerol-3-phosphate dehydrogenase activity IEA --
GO:0051287 NAD binding IEA --
genes like me logo Genes that share ontologies with GPD1: view

Phenotypes for GPD1 Gene

MGI mutant phenotypes for GPD1:
inferred from 1 alleles
GenomeRNAi human phenotypes for GPD1:
genes like me logo Genes that share phenotypes with GPD1: view

Human Phenotype Ontology for GPD1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA for GPD1 Gene

miRTarBase miRNAs that target GPD1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for GPD1 Gene

Localization for GPD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPD1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPD1 Gene COMPARTMENTS Subcellular localization image for GPD1 gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 3
nucleus 2
peroxisome 2

No data available for Gene Ontology (GO) - Cellular Components for GPD1 Gene

Pathways & Interactions for GPD1 Gene

genes like me logo Genes that share pathways with GPD1: view

Gene Ontology (GO) - Biological Process for GPD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006072 glycerol-3-phosphate metabolic process IEA --
GO:0006094 gluconeogenesis IEA --
GO:0006116 NADH oxidation IEA --
GO:0006644 phospholipid metabolic process TAS --
GO:0006654 phosphatidic acid biosynthetic process TAS --
genes like me logo Genes that share ontologies with GPD1: view

No data available for SIGNOR curated interactions for GPD1 Gene

Drugs & Compounds for GPD1 Gene

Products:

  1. Drug

(16) Drugs for GPD1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NADH Nutra Target 0
NAD Pharma Full agonist, Agonist 0

(28) Additional Compounds for GPD1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
glycerol 3-phosphate
  • 1-(Dihydrogen phosphate) Glycerol
  • 1-Glycerophosphate
  • 1-Glycerophosphorate
  • 1-Glycerophosphoric acid
  • 3-Glycerophosphate
 57-03-4
Dihydroxyacetone phosphate
  • 1,3-Dihydroxy-2-Propanone mono(dihydrogen phosphate)
  • 1,3-Dihydroxy-2-propanone phosphate
  • 1,3-Dihydroxyacetone 1-phosphate
  • 1-Hydroxy-3-(phosphonooxy)-2-Propanone
  • 1-Hydroxy-3-(phosphonooxy)acetone
 57-04-5
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
genes like me logo Genes that share compounds with GPD1: view

Transcripts for GPD1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for GPD1 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(207) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPD1 Gene

Glycerol-3-phosphate dehydrogenase 1 (soluble):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPD1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14
SP1: - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - -
SP5: - - -
SP6:
SP7:

Relevant External Links for GPD1 Gene

GeneLoc Exon Structure for
GPD1
ECgene alternative splicing isoforms for
GPD1

Expression for GPD1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for GPD1 Gene

mRNA expression in normal human tissues for GPD1 Gene
mRNA expression by BioGPS for GPD1 GenemRNA expression by GTEx for GPD1 Gene

mRNA differential expression in normal tissues according to GTEx for GPD1 Gene

This gene is overexpressed in Adipose - Subcutaneous (x12.5), Adipose - Visceral (Omentum) (x10.5), Muscle - Skeletal (x7.0), and Breast - Mammary Tissue (x6.1).

Protein differential expression in normal tissues from HIPED for GPD1 Gene

This gene is overexpressed in Nasopharynx (41.8) and Adipocyte (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GPD1 Gene



SOURCE GeneReport for Unigene cluster for GPD1 Gene Hs.524418

genes like me logo Genes that share expression patterns with GPD1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GPD1 Gene

Orthologs for GPD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia GPD1 35
  • 91.6 (n)
  • 92.55 (a)
GPD1 36
  • 93 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia GPD1 35
  • 90.07 (n)
  • 90.26 (a)
GPD1 36
  • 90 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Gpd1 35
  • 89.59 (n)
  • 93.98 (a)
Gpd1 16
Gpd1 36
  • 94 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia GPD1 35
  • 99.71 (n)
  • 99.71 (a)
GPD1 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Gpd1 35
  • 89.3 (n)
  • 94.27 (a)
platypus
(Ornithorhynchus anatinus)
 Mammalia GPD1 36
  • 82 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves LOC426881 35
  • 75.26 (n)
  • 79.37 (a)
GPD1 36
  • 77 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia GPD1 36
  • 84 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia gpd1 35
  • 74.4 (n)
  • 82.32 (a)
Str.11109 35
African clawed frog
(Xenopus laevis)
 Amphibia Xl.2478 35
zebrafish
(Danio rerio)
 Actinopterygii gpd1a 35
  • 71.69 (n)
  • 78.55 (a)
wufc30a07 35
gpd1a 36
  • 77 (a)
 OneToMany
gpd1b 36
  • 71 (a)
 OneToMany
fruit fly
(Drosophila melanogaster)
 Insecta CG3215 37
  • 45 (a)
Gpdh 37
  • 65 (a)
Gpdh 35
  • 67.91 (n)
  • 66.67 (a)
CG3215 36
  • 41 (a)
 ManyToMany
CG43343 36
  • 11 (a)
 ManyToMany
Gpdh 36
  • 60 (a)
 ManyToMany
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP007593 35
  • 66.57 (n)
  • 69.68 (a)
worm
(Caenorhabditis elegans)
 Secernentea F47G4.3 37
  • 50 (a)
gpdh-2 35
  • 59.58 (n)
  • 61.78 (a)
gpdh-1 36
  • 45 (a)
 ManyToMany
gpdh-2 36
  • 49 (a)
 ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
 Saccharomycetes AGOS_ADR311C 35
  • 56.67 (n)
  • 52.94 (a)
K. lactis yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0C04004g 35
  • 54.81 (n)
  • 53.99 (a)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes GPD1 35
  • 53.47 (n)
  • 50.76 (a)
GPD1 36
  • 41 (a)
 ManyToMany
GPD2 36
  • 35 (a)
 ManyToMany
GPD1 38
rice
(Oryza sativa)
 Liliopsida Os.24891 35
bread mold
(Neurospora crassa)
 Ascomycetes NCU00742 35
  • 55.45 (n)
  • 45.06 (a)
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes gpd1 35
  • 57.29 (n)
  • 55.39 (a)
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.1608 36
  • 57 (a)
 OneToMany
Species with no ortholog for GPD1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPD1 Gene

ENSEMBL:
Gene Tree for GPD1 (if available)
TreeFam:
Gene Tree for GPD1 (if available)

Paralogs for GPD1 Gene

Paralogs for GPD1 Gene

(1) SIMAP similar genes for GPD1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GPD1: view

Variants for GPD1 Gene

Sequence variations from dbSNP and Humsavar for GPD1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2232202 - 50,104,692(+) AGATC(A/G)TCAAC reference, missense
rs1128867 - 50,105,665(+) CAAAC(C/G)CCACT reference, missense
rs2232207 - 50,106,895(+) CACAG(C/T)AGAGA reference, missense
rs34783513 - 50,106,297(+) TAGAC(A/C/G)AGGGC reference, missense
VAR_067426 -

Variation tolerance for GPD1 Gene

Residual Variation Intolerance Score: 75.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.71; 46.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPD1 Gene

Human Gene Mutation Database (HGMD)
GPD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GPD1 Gene

Disorders for GPD1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for GPD1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hypertriglyceridemia, transient infantile
  • htgti
transient infantile hypertriglyceridemia and hepatosteatosis
  • transient infantile hypertriglyceridemia and fatty liver
hypertriglyceridemia
  • familial hypertriglyceridemia
obesity
  • obesity, association with
brugada syndrome
  • sudden unexpected nocturnal death syndrome
- elite association - COSMIC cancer census association via MalaCards
Search GPD1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

GPDA_HUMAN
  • Hypertriglyceridemia, transient infantile (HTGTI) [MIM:614480]: An autosomal recessive disorder characterized by onset of moderate to severe transient hypertriglyceridemia in infancy that normalizes with age. The hypertriglyceridemia is associated with hepatomegaly, moderately elevated transaminases, persistent fatty liver, and the development of hepatic fibrosis. {ECO:0000269 PubMed:22226083, ECO:0000269 PubMed:24549054}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for GPD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPD1
genes like me logo Genes that share disorders with GPD1: view

No data available for Genatlas for GPD1 Gene

Publications for GPD1 Gene

  1. Crystal structures of human glycerol 3-phosphate dehydrogenase 1 (GPD1). (PMID: 16460752) Ou X. … Rao Z. (J. Mol. Biol. 2006) 3 4 23 67
  2. The influence of obstructive sleep apnea on the expression of glycerol-3-phosphate dehydrogenase 1 gene. (PMID: 20404019) Guindalini C. … Tufik S. (Exp. Biol. Med. (Maywood) 2010) 3 23
  3. GRB14, GPD1, and GDF8 as potential network collaborators in weight loss-induced improvements in insulin action in human skeletal muscle. (PMID: 16849634) Park J.J. … Hoffman E.P. (Physiol. Genomics 2006) 3 23
  4. Enhanced glycerol 3-phosphate dehydrogenase activity in adipose tissue of obese humans. (PMID: 14674682) Swierczynski J. … Sledzinski Z. (Mol. Cell. Biochem. 2003) 3 23
  5. Ability of cytosolic malate dehydrogenase and lactate dehydrogenase to increase the ratio of NADPH to NADH oxidation by cytosolic glycerol-3-phosphate dehydrogenase. (PMID: 10190973) Fahien L.A. … Chobanian M. (Arch. Biochem. Biophys. 1999) 3 23

Products for GPD1 Gene

Sources for GPD1 Gene

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