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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GPD1 Gene

protein-coding   GIFtS: 64
GCID: GC12P050497

glycerol-3-phosphate dehydrogenase 1 (soluble)
 Explore 31 diseases affiliated with
GPD1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for GPD1    

Aliases
for GPD1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Glycerol-3-Phosphate Dehydrogenase 1 (Soluble)1 2     Glycerol-3-Phosphate Dehydrogenase [NAD(+)], Cytoplasmic2
GPD-C2 3     Glycerol-3-Phosphate Dehydrogenase [NAD+], Cytoplasmic2
GPDH-C2 3     Glycerophosphate Dehydrogenase2
EC 1.1.1.83 8     EC 1.1.18
HTGTI2     

External Ids:    HGNC: 44551   Entrez Gene: 28192   Ensembl: ENSG000001675887   OMIM: 1384205   UniProtKB: P216953   

Export aliases for GPD1 gene to outside databases

Previous GC identifers: GC12P050792 GC12P050553 GC12P050214 GC12P048784 GC12P047531


Summaries
for GPD1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for GPD1:
This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a
critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone
phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. The encoded
cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that
facilitates the transfer of reducing equivalents from the cytosol to mitochondria. Mutations in this gene are a cause
of transient infantile hypertriglyceridemia. Alternatively spliced transcript variants encoding multiple isoforms have
been observed for this gene. (provided by RefSeq, Mar 2012)




Genomic Views
for GPD1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GPD1 gene promoter:
         Lmo2   Olf-1   NF-kappaB   AP-2gamma   AREB6   S8   FOXC1   HSF2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GPD1 promoter sequence
   Search SABiosciences Chromatin IP Primers for GPD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q12-q13   Ensembl cytogenetic band:  12q13.12   HGNC chromosome: 12

GPD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPD1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P050497:  view genomic region     (about GC identifiers)

Start:
 50,497,602 bp from pter      End:
 50,505,102 bp from pter
Size:
 7,501 bases      Orientation:
 plus strand

Proteins
for GPD1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: GPDA_HUMAN, P21695 (See protein sequence)
Recommended Name: Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic  
Size: 349 amino acids; 37568 Da
Subunit: Homodimer
Subcellular location: Cytoplasm
3 PDB 3D structures from and Proteopedia for GPD1:
1WPQ (3D)        1X0V (3D)        1X0X (3D)    
Secondary accessions: F8W1L5 Q8N1B0
Alternative splicing: 2 isoforms:  P21695-1   P21695-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GPD1: NX_P21695

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P21695

    • 4/21 DME Specific Peptides for GPD1 (P21695) (see all 21)
     QTPNFRI  GDNTKAA  FVVPHQF  KLTEIIN 

    GPD1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001244128.1  NP_005267.2  

    ENSEMBL proteins: 
     ENSP00000301149   ENSP00000448244   ENSP00000449596   ENSP00000446768  
    Reactome Protein details: P21695
    Human Recombinant Protein Products: 
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    ProSpec Recombinant Protein for GPD1
    Uscn Proteins for GPD1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005625soluble fraction ----
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--
    GO:0009331glycerol-3-phosphate dehydrogenase complex IEA--


    GPD1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for GPD1

    Protein Domains /
    Families
    for GPD1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    GPD1 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR008927 6-PGluconate_DH_C-like
     IPR006168 G3P_DH_NAD-dep
     IPR017751 G3P_DH_NAD-dep_euk
     IPR006109 G3P_DH_NAD-dep_C
     IPR013328 DH_multihelical

    Graphical View of Domain Structure for InterPro Entry P21695

    ProtoNet protein and cluster: P21695

    1 Blocks protein family: IPB006168 NAD-dependent glycerol-3-phosphate dehydrogenase

    UniProtKB/Swiss-Prot: GPDA_HUMAN, P21695
    Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family


    Function
    for GPD1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: GPDA_HUMAN, P21695
    Catalytic activity: sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH
    Enzyme regulation: Inhibited by zinc ions and sulfate

         Genatlas biochemistry entry for GPD1:
    glycerol-3-phosphate dehydrogenase,NAD dependent,cytoplasmic

    Enzyme Numbers (IUBMB): EC 1.1.1.81 2 EC 1.1.12

    miRNA
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    hsa-mir-103 (MIRT001842)

    OriGene 3'-UTR Clone: GPD1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GPD1
    8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate GPD1 (see all 41):
    hsa-miR-4291 hsa-miR-4254 hsa-miR-631 hsa-miR-513a-5p hsa-miR-200a hsa-miR-4267 hsa-miR-141 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmid: GPD1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GPD1 (see all 7)
    OriGene shRNA RFP: GPD1
    OriGene siRNA: GPD1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GPD1

    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPD1 

    Cell Line
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    Search LifeMap BioReagents cell lines for GPD1

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004367glycerol-3-phosphate dehydrogenase [NAD+] activity IEA--
    GO:0004368glycerol-3-phosphate dehydrogenase activity IEA--
    GO:0042803protein homodimerization activity IEA--
    GO:0051287NAD binding IEA--


    GPD1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for GPD1:
     Synthetic lethal with Ras 

    Animal Models:
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Gpd1):
     growth/size  homeostasis/metabolism  reproductive system 

    GPD1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for GPD1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Glycerophospholipid biosynthesis
    		Glycerophospholipid biosynthesis1.00
    		Glycerophospholipid metabolism0.54
    		Phospholipid metabolism0.64
    2Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34
    3glycerol-3-phosphate shuttle
    		glycerol-3-phosphate shuttle1.00
    4Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    		Fatty acid, triacylglycerol, and ketone body metabolism0.52
    5Fatty Acyl-CoA Biosynthesis
    		Triglyceride Biosynthesis0.47

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 BioSystems Pathways for GPD1 
        glycerol-3-phosphate shuttle
    Triacylglyceride Synthesis

    5/7        Reactome Pathways for GPD1 (see all 7)
        Glycerophospholipid biosynthesis
    Synthesis of PA
    Metabolism
    Phospholipid metabolism
    Triglyceride Biosynthesis


    1         Kegg Pathway  (Kegg details for GPD1):
        Glycerophospholipid metabolism


    GPD1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GPD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/46 Interacting proteins for GPD1 (P216952, 3 ENSP000003011494) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTNP212462, 3MINT-63594 I2D: score=5 
    MDH1P409253, ENSP000002331144I2D: score=2 STRING: ENSP00000233114
    GPD2P433043, ENSP000003086104I2D: score=1 STRING: ENSP00000308610
    PEX7O006283, ENSP000003156804I2D: score=2 STRING: ENSP00000315680
    PSMD4P550363I2D: score=4 
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process ----
    GO:0006072glycerol-3-phosphate metabolic process ----
    GO:0006094gluconeogenesis IEA--
    GO:0006116NADH oxidation IEA--
    GO:0006644phospholipid metabolic process TAS--


    GPD1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for GPD1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GPD1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GPD1

    4 HMDB Compounds for GPD1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Dihydroxyacetone phosphate1,3-Dihydroxy-2-propanone phosphate (see all 17)57-04-5--
    Glycerol 3-phosphate1-(dihydrogen phosphate) Glycerol (see all 37)57-03-4--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--

    1 DrugBank Compound for GPD1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17088060

    10/41 Novoseek chemical compound relationships for GPD1 gene (see all 41)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycerol 3-phosphate 98 269 10190973 (6), 14605988 (5), 12548942 (5), 2226800 (3) (see all 99)
    dhap 67 5 16460752 (2), 18376850 (1)
    troglitazone 57.9 3 12861228 (1), 12895585 (1), 16483873 (1)
    lipid 57.9 36 14605988 (2), 1976021 (1), 8126079 (1), 9062891 (1) (see all 27)
    succinate 56.7 14 8351966 (2), 9431688 (2), 8130177 (1), 7812436 (1) (see all 11)
    fatty acid 56.6 29 12643487 (1), 9075710 (1), 11606486 (1), 14605988 (1) (see all 18)
    ibmx 56.1 1 12861228 (1)
    glycerol 52.8 23 12548942 (5), 7812436 (1), 17242918 (1), 14524727 (1) (see all 5)
    6-phosphogluconate 50.4 3 14605988 (1), 12196534 (1), 12604241 (1)
    glyceraldehyde 3-phosphate 48.1 6 9831620 (1), 10336621 (1), 1315269 (1), 16913842 (1) (see all 6)

    Search CenterWatch for drugs/clinical trials and news about GPD1 / GPDA 

    Transcripts
    for GPD1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for GPD1 gene (2 alternative transcripts): 
    NM_001257199.1  NM_005276.3  

    Unigene Cluster for GPD1:

    Glycerol-3-phosphate dehydrogenase 1 (soluble)
    Hs.524418  [show with all ESTs]
    Unigene Representative Sequence: NM_005276
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000301149(uc001rvz.3 uc001rwa.3) ENST00000547964 ENST00000551939(uc010smp.1)
    ENST00000547190 ENST00000548814 ENST00000548152 ENST00000550172

    miRNA
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    8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate GPD1 (see all 41):
    hsa-miR-4291 hsa-miR-4254 hsa-miR-631 hsa-miR-513a-5p hsa-miR-200a hsa-miR-4267 hsa-miR-141 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmid: GPD1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AK130162.1 AK295911.1 AK312516.1 BC032234.1 L34041.1 

    5 DOTS entries:

    DT.113922  DT.92021196  DT.100785873  DT.95327703  DT.121193033 

    24/207 AceView cDNA sequences (see all 207):

    BU740595 AI640150 CA306971 CD515894 BM547808 BP381758 BM918911 CD369829 
    AA910870 AI264177 BI759262 BP334715 BM728256 H26339 BM723668 CA309616 
    BP381762 BI833137 F34722 CD367253 AK130162 AI245302 AU122033 BI758943 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for GPD1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14
    SP1:                    -     -           -     -                             -                                             
    SP2:                    -     -           -                                   -                                             
    SP3:                    -     -           -           -     -                 -                                             
    SP4:                    -                 -                                                                                 
    SP5:                                      -                 -     -                                                         


    ECgene alternative splicing isoforms for GPD1

    Expression
    for GPD1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GPD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTGGCATCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    GPD1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/15 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 15) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyLoop of HenleLoop of Henle CellsKidney
    KidneyProximal TubuleProximal Tubule CellsKidney
    AdiposeBody Subcutaneous White AdiposeAdipose
    AdiposeVisceral White AdiposeAdipose
    BrainMedulla OblongataBrain
    KidneyEpithelial TubuleKidney
    KidneyGlomerular TuftKidney
    KidneyGlomerulusKidney
    KidneyLoop of HenleKidney
    KidneyMetanephrosKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    White adipocyte-like cells (Differentiation of ...)Adipose
    Human kidney epithelial cell spheroids (Kidney spheroids for...)

    See GPD1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GPD1

    SOURCE GeneReport for Unigene cluster: Hs.524418
        SABiosciences Expression via Pathway-Focused PCR Arrays including GPD1: 
              Insulin Signaling Pathway in human mouse rat
              Fatty Acid Metabolism in human mouse rat
              Diabetes in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPD1

    Orthologs
    for GPD1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for GPD1 gene from 11/38 species (see all 38)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Gpd11 , 5 glycerol-3-phosphate dehydrogenase 1 (soluble)1, 5 89.59(n)1
    93.98(a)1    		   15 (56.13 cM)5
    145551  NM_010271.21  NP_034401.11 
     997175155 
    chicken
    (Gallus gallus)    		 Aves LOC4268811 glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic-like less 75.26(n)
    79.37(a)    		   426881  XM_003643117.1  XP_003643165.1 
    lizard
    (Anolis carolinensis)    		 Reptilia GPD16
    		 --
    		 80(a)
    		 1 ↔ 1
    		 2(91637507-91652517)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.24782 Xenopus laevis, Similar to glycerol phosphate dehydrogenase 1, cytoplasmic adult, clone IMAGE4888802, mRNA, partial cds less 76.12(n)    BC043631.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufc30a072 Danio rerio glycerol-3-phosphate dehydrogenase 1, mRNA (cDNA clone MGC63859 IMAGE6789017), complete cds less 78.01(n)    BC053116.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Gpdh1 , 3 glycerophosphate shuttle
    glycerol-3-phosphate dehydrogenase (NAD+) less3
    Glycerol 3 phosphate dehydrogenase1    		 65(a)
    (best of 2)3
    67.91(n)1
    66.67(a)1    		   26A33
    338241  NM_057218.31  NP_476566.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea F47G4.33
    gpdh-21    		 NAD-dependent glycerol-3-phosphate
    dehydrogenase less3
    Protein GPDH-21    		 50(a)3
    59.58(n)1
    61.49(a)1    		   I(14083918-14086109)3
    1763991  NM_181903.41  NP_871632.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes GPD1(YDL022W)4
    GPD11    		 NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p less4
    Gpd1p1    		 53.47(n)1
    50.76(a)1    		   4(411825-413000)4
    8515391, 4  NP_010262.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT5G406101 glycerol-3-phosphate dehydrogenase [NAD+] 57.19(n)
    53.21(a)    		   834060  NM_123425.4  NP_198877.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.248912 Oryza sativa (japonica cultivar-group) cDNA cloneJ023050E11, full insert sequence less 76.79(n)    AK070366.1 


    ENSEMBL Gene Tree for GPD1 (if available)
    TreeFam Gene Tree for GPD1 (if available) 

    Paralogs
    for GPD1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GPD1 gene
    GPD1L2  
    1 SIMAP similar gene for GPD1 using alignment to 3 protein entries:     GPDA_HUMAN (see all proteins):
    GPD1L

    GPD1 for paralogs           About GeneDecksing



    Genomic Variants
    for GPD1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/174 NCBI SNPs in GPD1 are shown (see all 174)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs38135241,2
    		C,F,H,--47529365(+) ATGAGC/TACATT 2 -- us2k15Minor allele frequency- T:0.01EA NS NA 342
    rs787421711,2
    		--47529485(+) CCCATA/CATTTG 2 -- us2k10--------
    rs38135251,2
    		C,F,--47530482(+) AGACAA/GTCTTG 2 -- us2k11Minor allele frequency- G:0.07EA 120
    rs1116783961,2
    		C--47531197(+) ACTGGA/G/TAAGCA 2 -- spd11CSA 1
    rs801557211,2
    		--47531440(+) AGTTTA/GGGGGT 2 -- int10--------
    rs2010204841,2
    		C,F--47531875(+) CCTGCG/AAAGAA 2 -- int12Minor allele frequency- A:0.00MN EU 1253
    rs178489971,2
    		C,--47532127(+) TGGGGA/TCCAGT 2 -- int10--------
    rs1127494781,2
    		--47533027(+) GTTTCC/GGAGGT 2 -- int11Minor allele frequency- G:0.00CSA 1
    rs22322031,2
    		--47533278(+) GGCAGA/GACCTG 2 -- int10--------
    rs22322041,2
    		--47533319(+) GGAAGG/AGACAG 2 -- int11Minor allele frequency- A:0.01NA 120

    HapMap Linkage Disequilibrium report for GPD1 (50497602 - 50505102 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for GPD1: --
    Human Gene Mutation Database (HGMD): GPD1

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for GPD1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    GPD1 for disorders           About GeneDecksing

    OMIM gene information: 138420    OMIM disorders: --

    UniProtKB/Swiss-Prot: GPDA_HUMAN, P21695
  • Defects in GPD1 are a cause of hypertriglyceridemia, transient infantile (HTGTI) [MIM:614480]. An autosomal
    • recessive disorder characterized by onset of moderate to severe transient hypertriglyceridemia in infancy that
    normalizes with age. The hypertriglyceridemia is associated with hepatomegaly, moderately elevated transaminases,
    persistent fatty liver, and the development of hepatic fibrosis

    20/31 diseases for GPD1 (see all 31):    About MalaCards
    lactate dehydrogenase a deficiency    cleft lip/palate    cleft lip    type 2 diabetes mellitus
    hypertriglyceridemia    sleep apnea    cleft palate    diabetes mellitus
    brugada syndrome    apnea    insulin resistance    convulsions
    liposarcoma    duodenitis    aldosteronism    acute leukemia
    obesity    myopathy    blindness    colorectal cancer

    3 Novoseek disease relationships for GPD1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 53.9 2 20404019 (1), 7857262 (1)
    necrosis 0.704 1 9492058 (1)
    tumors 0 1 9492058 (1)


    Export disorders for GPD1 gene to outside databases

    Publications
    for GPD1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GPD1 gene, integrated from 9 sources (see all 191):
    (articles sorted by number of sources associating them with GPD1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structures of human glycerol 3-phosphate dehydrogenase 1 (GPD1). (PubMed id 16460752)1, 2, 9 Ou X....Rao Z. (2006)
    2. Sequence conservation and structural organization of the glycerol-3- phosphate dehydrogenase promoter in mice and humans. (PubMed id 2398890)1, 2, 9 Gwynn B.... Birkenmeier E.H. (1990)
    3. Transient infantile hypertriglyceridemia, fatty liver, and hepatic fibrosis caused by mutated GPD1, encoding glycerol-3-phosphate dehydrogenase 1. (PubMed id 22226083)1, 2 Basel-Vanagaite L.... Shamir R. (2012)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Molecular cloning, sequencing and expression of a cDNA encoding a human liver NAD-dependent alpha-glycerol-3-phosphate dehydrogenase. (PubMed id 7772607)1, 2 Menaya J.... Ayuso M.S. (1995)
    6. The influence of obstructive sleep apnea on the expre ssion of glycerol-3-phosphate dehydrogenase 1 gene. (PubMed id 20404019)1, 9 Guindalini C....Tufik S. (2010)
    7. Ability of cytosolic malate dehydrogenase and lactate dehydrogenase to increase the ratio of NADPH to NADH oxidation by cytosolic glycerol-3-phosphate dehydrogenase. (PubMed id 10190973)1, 9 Fahien L.A....Chobanian M. (1999)
    8. GRB14, GPD1, and GDF8 as potential network collaborators in weight loss-induced improvements in insulin action in human skeletal muscle. (PubMed id 16849634)1, 9 Park J.J....Hoffman E.P. (2006)
    9. Enhanced glycerol 3-phosphate dehydrogenase activity in adipose tissue of obese humans. (PubMed id 14674682)1, 9 Swierczynski J....Sledzinski Z. (2003)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    External Searches for GPD1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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    Genome Databases showing GPD1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2819 HGNC: 4455 AceView: GPD1 Ensembl:ENSG00000167588 euGenes: HUgn2819
    ECgene: GPD1 Kegg: 2819 H-InvDB: GPD1

    Other Databases showing GPD1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing GPD1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GPD1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for GPD1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for GPD1 gene:
    Search GeneIP for patents involving GPD1

    GeneCards and IP:
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