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Aliases for GPD1 Gene

Aliases for GPD1 Gene

  • Glycerol-3-Phosphate Dehydrogenase 1 (Soluble) 2 3
  • EC 1.1.1.8 4 63
  • GPDH-C 3 4
  • GPD-C 3 4
  • Glycerol-3-Phosphate Dehydrogenase [NAD+], Cytoplasmic 3
  • Glycerophosphate Dehydrogenase 3
  • EC 1.1.1 63
  • HTGTI 3

External Ids for GPD1 Gene

Previous GeneCards Identifiers for GPD1 Gene

  • GC12P050792
  • GC12P050553
  • GC12P050214
  • GC12P048784
  • GC12P050497
  • GC12P047531

Summaries for GPD1 Gene

Entrez Gene Summary for GPD1 Gene

  • This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria. Mutations in this gene are a cause of transient infantile hypertriglyceridemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

GeneCards Summary for GPD1 Gene

GPD1 (Glycerol-3-Phosphate Dehydrogenase 1 (Soluble)) is a Protein Coding gene. Diseases associated with GPD1 include transient infantile hypertriglyceridemia and hepatosteatosis and hypertriglyceridemia, transient infantile. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include protein homodimerization activity and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. An important paralog of this gene is GPD1L.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPD1 Gene

Genomics for GPD1 Gene

Regulatory Elements for GPD1 Gene

Genomic Location for GPD1 Gene

Chromosome:
12
Start:
50,103,819 bp from pter
End:
50,111,320 bp from pter
Size:
7,502 bases
Orientation:
Plus strand

Genomic View for GPD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPD1 Gene

Proteins for GPD1 Gene

  • Protein details for GPD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21695-GPDA_HUMAN
    Recommended name:
    Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
    Protein Accession:
    P21695
    Secondary Accessions:
    • F8W1L5
    • Q8N1B0

    Protein attributes for GPD1 Gene

    Size:
    349 amino acids
    Molecular mass:
    37568 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for GPD1 Gene

    Alternative splice isoforms for GPD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPD1 Gene

Proteomics data for GPD1 Gene at MOPED

Post-translational modifications for GPD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPD1 Gene

Antibody Products

Domains & Families for GPD1 Gene

Suggested Antigen Peptide Sequences for GPD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P21695

UniProtKB/Swiss-Prot:

GPDA_HUMAN :
  • Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
Family:
  • Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
genes like me logo Genes that share domains with GPD1: view

No data available for Gene Families for GPD1 Gene

Function for GPD1 Gene

Molecular function for GPD1 Gene

GENATLAS Biochemistry:
glycerol-3-phosphate dehydrogenase,NAD dependent,cytoplasmic
UniProtKB/Swiss-Prot CatalyticActivity:
sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by zinc ions and sulfate.

Enzyme Numbers (IUBMB) for GPD1 Gene

Gene Ontology (GO) - Molecular Function for GPD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity IEA --
GO:0004368 glycerol-3-phosphate dehydrogenase activity IEA --
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor --
GO:0042803 protein homodimerization activity IEA --
GO:0051287 NAD binding IEA --
genes like me logo Genes that share ontologies with GPD1: view
genes like me logo Genes that share phenotypes with GPD1: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPD1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for GPD1 Gene

Localization for GPD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPD1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPD1 Gene COMPARTMENTS Subcellular localization image for GPD1 gene
Compartment Confidence
extracellular 5
cytosol 4
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for GPD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0009331 glycerol-3-phosphate dehydrogenase complex IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with GPD1: view

Pathways & Interactions for GPD1 Gene

genes like me logo Genes that share pathways with GPD1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for GPD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process --
GO:0006072 glycerol-3-phosphate metabolic process --
GO:0006094 gluconeogenesis IEA --
GO:0006116 NADH oxidation --
GO:0006127 glycerophosphate shuttle IEA --
genes like me logo Genes that share ontologies with GPD1: view

No data available for SIGNOR curated interactions for GPD1 Gene

Drugs & Compounds for GPD1 Gene

(16) Drugs for GPD1 Gene - From: NovoSeek, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dexamethasone Approved, Investigational Pharma Agonist 1806
Nitric Oxide Approved Pharma 540
Norepinephrine Approved Pharma 206
Progesterone Approved Pharma Inhibition, Pore Blocker Endogenous progesterone receptor agonist 473
Rosiglitazone Approved, Investigational Pharma Channel blocker Potent PPARγ agonist 219

(28) Additional Compounds for GPD1 Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
glycerol 3-phosphate
  • 1-(Dihydrogen phosphate) Glycerol
  • 1-Glycerophosphate
  • 1-Glycerophosphorate
  • 1-Glycerophosphoric acid
  • 3-Glycerophosphate
57-03-4
Dihydroxyacetone phosphate
  • 1,3-Dihydroxy-2-Propanone mono(dihydrogen phosphate)
  • 1,3-Dihydroxy-2-propanone phosphate
  • 1,3-Dihydroxyacetone 1-phosphate
  • 1-Hydroxy-3-(phosphonooxy)-2-Propanone
  • 1-Hydroxy-3-(phosphonooxy)acetone
57-04-5
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
6-phosphogluconate
alpha-ketoglutarate
genes like me logo Genes that share compounds with GPD1: view

Transcripts for GPD1 Gene

Unigene Clusters for GPD1 Gene

Glycerol-3-phosphate dehydrogenase 1 (soluble):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPD1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPD1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14
SP1: - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - -
SP5: - - -
SP6:
SP7:

Relevant External Links for GPD1 Gene

GeneLoc Exon Structure for
GPD1
ECgene alternative splicing isoforms for
GPD1

Expression for GPD1 Gene

mRNA expression in normal human tissues for GPD1 Gene

mRNA differential expression in normal tissues according to GTEx for GPD1 Gene

This gene is overexpressed in Adipose - Subcutaneous (x12.5), Adipose - Visceral (Omentum) (x10.5), Muscle - Skeletal (x7.0), and Breast - Mammary Tissue (x6.1).

Protein differential expression in normal tissues from HIPED for GPD1 Gene

This gene is overexpressed in Nasopharynx (41.8) and Adipocyte (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GPD1 Gene



SOURCE GeneReport for Unigene cluster for GPD1 Gene Hs.524418

genes like me logo Genes that share expression patterns with GPD1: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GPD1 Gene

Orthologs for GPD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPD1 35
  • 91.6 (n)
  • 92.55 (a)
GPD1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPD1 35
  • 90.07 (n)
  • 90.26 (a)
GPD1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpd1 35
  • 89.59 (n)
  • 93.98 (a)
Gpd1 16
Gpd1 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPD1 35
  • 99.71 (n)
  • 99.71 (a)
GPD1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpd1 35
  • 89.3 (n)
  • 94.27 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia GPD1 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC426881 35
  • 75.26 (n)
  • 79.37 (a)
GPD1 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPD1 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpd1 35
  • 74.4 (n)
  • 82.32 (a)
Str.11109 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.2478 35
zebrafish
(Danio rerio)
Actinopterygii gpd1a 35
  • 71.69 (n)
  • 78.55 (a)
wufc30a07 35
gpd1a 36
  • 77 (a)
OneToMany
gpd1b 36
  • 71 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG3215 37
  • 45 (a)
Gpdh 37
  • 65 (a)
Gpdh 35
  • 67.91 (n)
  • 66.67 (a)
CG3215 36
  • 41 (a)
ManyToMany
CG43343 36
  • 11 (a)
ManyToMany
Gpdh 36
  • 60 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007593 35
  • 66.57 (n)
  • 69.68 (a)
worm
(Caenorhabditis elegans)
Secernentea F47G4.3 37
  • 50 (a)
gpdh-2 35
  • 59.58 (n)
  • 61.78 (a)
gpdh-1 36
  • 45 (a)
ManyToMany
gpdh-2 36
  • 49 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR311C 35
  • 56.67 (n)
  • 52.94 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C04004g 35
  • 54.81 (n)
  • 53.99 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GPD1 35
  • 53.47 (n)
  • 50.76 (a)
GPD1 36
  • 41 (a)
ManyToMany
GPD2 36
  • 35 (a)
ManyToMany
GPD1 38
rice
(Oryza sativa)
Liliopsida Os.24891 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00742 35
  • 55.45 (n)
  • 45.06 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gpd1 35
  • 57.29 (n)
  • 55.39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1608 36
  • 57 (a)
OneToMany
Species with no ortholog for GPD1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPD1 Gene

ENSEMBL:
Gene Tree for GPD1 (if available)
TreeFam:
Gene Tree for GPD1 (if available)

Paralogs for GPD1 Gene

Paralogs for GPD1 Gene

(1) SIMAP similar genes for GPD1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GPD1: view

Variants for GPD1 Gene

Sequence variations from dbSNP and Humsavar for GPD1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs836178 -- 50,104,356(+) AGAAG(G/T)GGGGC intron-variant
rs1046194 -- 50,104,619(+) CAGCT(C/G)GCACA synonymous-codon, reference
rs1128867 - 50,105,665(+) CAAAC(C/G)CCACT missense, reference
rs2232202 - 50,104,692(+) AGATC(A/G)TCAAC reference, missense
rs2232203 -- 50,106,174(+) GGCAG(A/G)ACCTG intron-variant

Variation tolerance for GPD1 Gene

Residual Variation Intolerance Score: 75.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.71; 46.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPD1 Gene

HapMap Linkage Disequilibrium report
GPD1
Human Gene Mutation Database (HGMD)
GPD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GPD1 Gene

Disorders for GPD1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for GPD1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
transient infantile hypertriglyceridemia and hepatosteatosis
  • transient infantile hypertriglyceridemia and fatty liver
hypertriglyceridemia, transient infantile
  • htgti
hypertriglyceridemia
  • familial hypertriglyceridemia
brugada syndrome
  • sudden unexpected nocturnal death syndrome
obesity
  • obesity, association with
- elite association
Search GPD1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

GPDA_HUMAN
  • Hypertriglyceridemia, transient infantile (HTGTI) [MIM:614480]: An autosomal recessive disorder characterized by onset of moderate to severe transient hypertriglyceridemia in infancy that normalizes with age. The hypertriglyceridemia is associated with hepatomegaly, moderately elevated transaminases, persistent fatty liver, and the development of hepatic fibrosis. {ECO:0000269 PubMed:22226083, ECO:0000269 PubMed:24549054}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for GPD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPD1
genes like me logo Genes that share disorders with GPD1: view

No data available for Genatlas for GPD1 Gene

Publications for GPD1 Gene

  1. The influence of obstructive sleep apnea on the expression of glycerol-3-phosphate dehydrogenase 1 gene. (PMID: 20404019) Guindalini C. … Tufik S. (Exp. Biol. Med. (Maywood) 2010) 23 67
  2. Effects of androgens on adipocyte differentiation and adipose tissue explant metabolism in men and women. (PMID: 19500113) Blouin K. … Tchernof A. (Clin. Endocrinol. (Oxf) 2010) 23 67
  3. Knockdown of angiotensinogen by shRNA-mediated RNA interference inhibits human visceral preadipocytes differentiation. (PMID: 19786968) Ye Z.W. … Jiang J.G. (Int J Obes (Lond) 2010) 23 67
  4. The sites and topology of mitochondrial superoxide production. (PMID: 20064600) Brand M.D. (Exp. Gerontol. 2010) 23 67
  5. Genistein inhibits differentiation of primary human adipocytes. (PMID: 18547799) Park H.J. … Baile C.A. (J. Nutr. Biochem. 2009) 23 67

Products for GPD1 Gene

Sources for GPD1 Gene

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