Aliases for GPD1 Gene
External Ids for GPD1 Gene
Previous GeneCards Identifiers for GPD1 Gene
This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria. Mutations in this gene are a cause of transient infantile hypertriglyceridemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
GeneCards Summary for GPD1 Gene
GPD1 (Glycerol-3-Phosphate Dehydrogenase 1) is a Protein Coding gene. Diseases associated with GPD1 include hypertriglyceridemia, transient infantile and transient infantile hypertriglyceridemia and hepatosteatosis. Among its related pathways are Glycerophospholipid biosynthesis and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include protein homodimerization activity and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. An important paralog of this gene is GPD1L.