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GPD1 Gene

protein-coding   GIFtS: 67
GCID: GC12P050497

Glycerol-3-Phosphate Dehydrogenase 1 (Soluble)

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glycerol-3-Phosphate Dehydrogenase 1 (Soluble)1 2     Glycerol-3-Phosphate Dehydrogenase [NAD(+)], Cytoplasmic2
GPD-C2 3     Glycerol-3-Phosphate Dehydrogenase [NAD+], Cytoplasmic2
GPDH-C2 3     Glycerophosphate Dehydrogenase2
EC 1.1.1.83 8     EC 1.1.18
HTGTI2 5     

External Ids:    HGNC: 44551   Entrez Gene: 28192   Ensembl: ENSG000001675887   OMIM: 1384205   UniProtKB: P216953   

Export aliases for GPD1 gene to outside databases

Previous GC identifers: GC12P050792 GC12P050553 GC12P050214 GC12P048784 GC12P047531


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GPD1 Gene:
This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein
plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of
dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P)
and NAD+. The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol
phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria.
Mutations in this gene are a cause of transient infantile hypertriglyceridemia. Alternatively spliced transcript
variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Mar 2012)

GeneCards Summary for GPD1 Gene:
GPD1 (glycerol-3-phosphate dehydrogenase 1 (soluble)) is a protein-coding gene. Diseases associated with GPD1 include hypertriglyceridemia, transient infantile, and lactate dehydrogenase a deficiency. GO annotations related to this gene include glycerol-3-phosphate dehydrogenase [NAD+] activity and protein homodimerization activity. An important paralog of this gene is GPD1L.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the GPD1 gene promoter:
         Lmo2   Olf-1   NF-kappaB   AP-2gamma   AREB6   S8   FOXC1   HSF2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPD1 promoter sequence
   Search Chromatin IP Primers for GPD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GPD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.12   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q13.12

GPD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPD1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P050497:  view genomic region     (about GC identifiers)

Start:
50,497,602 bp from pter      End:
50,505,102 bp from pter
Size:
7,501 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: GPDA_HUMAN, P21695 (See protein sequence)
Recommended Name: Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic  
Size: 349 amino acids; 37568 Da
Subunit: Homodimer
3 PDB 3D structures from and Proteopedia for GPD1:
1WPQ (3D)        1X0V (3D)        1X0X (3D)    
Secondary accessions: F8W1L5 Q8N1B0
Alternative splicing: 2 isoforms:  P21695-1   P21695-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GPD1: NX_P21695

Explore proteomics data for GPD1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for GPD1 (P21695) (see all 21)
     QTPNFRI  GDNTKAA  FVVPHQF  KLTEIIN 


    See GPD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001244128.1  NP_005267.2  

    ENSEMBL proteins: 
     ENSP00000301149   ENSP00000448244   ENSP00000446768  
    Reactome Protein details: P21695

    GPD1 Human Recombinant Protein Products:

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    OriGene Purified Protein for GPD1
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    Novus Biologicals GPD1 Proteins
    Novus Biologicals GPD1 Lysate
    Sino Biological Recombinant Protein for GPD1
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for GPD1
    Cloud-Clone Corp. Proteins for GPD1

    GPD1 Antibody Products:

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    ThermoFisher Antibody for GPD1
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    GPD1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for GPD1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GPD1
    Cloud-Clone Corp. CLIAs for GPD1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR008927 6-PGluconate_DH_C-like
     IPR006168 G3P_DH_NAD-dep
     IPR017751 G3P_DH_NAD-dep_euk
     IPR006109 G3P_DH_NAD-dep_C
     IPR013328 DH_multihelical

    Graphical View of Domain Structure for InterPro Entry P21695

    ProtoNet protein and cluster: P21695

    1 Blocks protein domain: IPB006168 NAD-dependent glycerol-3-phosphate dehydrogenase

    UniProtKB/Swiss-Prot: GPDA_HUMAN, P21695
    Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family


    GPD1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GPDA_HUMAN, P21695
    Catalytic activity: sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH
    Enzyme regulation: Inhibited by zinc ions and sulfate

         Genatlas biochemistry entry for GPD1:
    glycerol-3-phosphate dehydrogenase,NAD dependent,cytoplasmic

         Enzyme Numbers (IUBMB): EC 1.1.1.81 2 EC 1.1.12

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004367glycerol-3-phosphate dehydrogenase [NAD+] activity IEA--
    GO:0004368glycerol-3-phosphate dehydrogenase activity IEA--
    GO:0016616oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ----
    GO:0042803protein homodimerization activity IEA--
    GO:0051287NAD binding IEA--
         
    GPD1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GPD1:
     Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Gpd1):
     growth/size/body  homeostasis/metabolism  reproductive system 

    GPD1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GPD1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GPD1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GPD1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GPD1

    miRNA
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    miRTarBase miRNAs that target GPD1:
    hsa-mir-103a-3p (MIRT001842)

    Block miRNA regulation of human, mouse, rat GPD1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GPD1 (see all 41):
    hsa-miR-4291 hsa-miR-4254 hsa-miR-631 hsa-miR-513a-5p hsa-miR-200a hsa-miR-4267 hsa-miR-141 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidGPD1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GPD1
    Predesigned siRNA for gene silencing in human, mouse, rat GPD1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GPD1

    Clone
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    OriGene clones in human, mouse for GPD1 (see all 6)
    OriGene ORF clones in mouse, rat for GPD1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GPD1 (NM_005276)
    Sino Biological Human cDNA Clone for GPD1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GPD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPD1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for GPD1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPD1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GPDA_HUMAN, P21695: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    mitochondrion2
    nucleus2
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--
    GO:0009331glycerol-3-phosphate dehydrogenase complex IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    GPD1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GPD1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Glycerophospholipid biosynthesis
    Glycerophospholipid biosynthesis0.64
    Synthesis of PA0.33
    Phospholipid metabolism0.64
    glycerol-3-phosphate shuttle0.00
    Glycerophospholipid metabolism0.62
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    3Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    4triacylglycerol biosynthesis
    Triacylglyceride Synthesis0.36
    5Triglyceride Biosynthesis
    Triglyceride Biosynthesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for GPD1
        glycerol-3-phosphate shuttle
    Triacylglyceride Synthesis


    2 Reactome Pathways for GPD1
        Synthesis of PA
    Triglyceride Biosynthesis


    1 Kegg Pathway  (Kegg details for GPD1):
        Glycerophospholipid metabolism


    GPD1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GPD1: 
              Insulin Signaling Pathway in human mouse rat
              Fatty Acid Metabolism in human mouse rat
              Diabetes in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for GPD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GPD1 (P216952, 3 ENSP000003011494) via UniProtKB, MINT, STRING, and/or I2D (see all 125)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTNP212462, 3MINT-63594 I2D: score=5 
    PSMD4P550363, ENSP000003578794I2D: score=4 STRING: ENSP00000357879
    MDH1P409253, ENSP000002331144I2D: score=2 STRING: ENSP00000233114
    GAPDHP044063, ENSP000002292394I2D: score=1 STRING: ENSP00000229239
    GPD2P433043, ENSP000003086104I2D: score=1 STRING: ENSP00000308610
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process ----
    GO:0006072glycerol-3-phosphate metabolic process ----
    GO:0006094gluconeogenesis IEA--
    GO:0006116NADH oxidation IEA--
    GO:0006644phospholipid metabolic process TAS--

    GPD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GPD1 (GPDA)

    4 HMDB Compounds for GPD1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Dihydroxyacetone phosphate1,3-Dihydroxy-2-propanone phosphate (see all 17)57-04-5--
    Glycerol 3-phosphate1-(dihydrogen phosphate) Glycerol (see all 37)57-03-4--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--

    1 DrugBank Compound for GPD1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17088060

    Selected Novoseek inferred chemical compound relationships for GPD1 gene (see all 41)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycerol 3-phosphate 98 269 10190973 (6), 14605988 (5), 12548942 (5), 2226800 (3) (see all 99)
    dhap 67 5 16460752 (2), 18376850 (1)
    troglitazone 57.9 3 12861228 (1), 12895585 (1), 16483873 (1)
    lipid 57.9 36 14605988 (2), 1976021 (1), 8126079 (1), 9062891 (1) (see all 27)
    succinate 56.7 14 8351966 (2), 9431688 (2), 8130177 (1), 7812436 (1) (see all 11)
    fatty acid 56.6 29 12643487 (1), 9075710 (1), 11606486 (1), 14605988 (1) (see all 18)
    ibmx 56.1 1 12861228 (1)
    glycerol 52.8 23 12548942 (5), 7812436 (1), 17242918 (1), 14524727 (1) (see all 5)
    6-phosphogluconate 50.4 3 14605988 (1), 12196534 (1), 12604241 (1)
    glyceraldehyde 3-phosphate 48.1 6 9831620 (1), 10336621 (1), 1315269 (1), 16913842 (1) (see all 6)



    GPD1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GPD1 gene (2 alternative transcripts): 
    NM_001257199.1  NM_005276.3  

    Unigene Cluster for GPD1:

    Glycerol-3-phosphate dehydrogenase 1 (soluble)
    Hs.524418  [show with all ESTs]
    Unigene Representative Sequence: NM_005276
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000301149(uc001rvz.3 uc001rwa.3) ENST00000547964 ENST00000551939(uc010smp.1)
    ENST00000547190 ENST00000548814 ENST00000548152 ENST00000550172
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate GPD1 (see all 41):
    hsa-miR-4291 hsa-miR-4254 hsa-miR-631 hsa-miR-513a-5p hsa-miR-200a hsa-miR-4267 hsa-miR-141 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidGPD1 3' UTR sequence
    Inhib. RNA
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GPD1 (NM_005276)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GPD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPD1
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GPD1
      QuantiTect SYBR Green Assays in human, mouse, rat GPD1
      QuantiFast Probe-based Assays in human, mouse, rat GPD1

    Additional mRNA sequence: 

    AK130162.1 AK295911.1 AK312516.1 BC032234.1 L34041.1 

    5 DOTS entries:

    DT.113922  DT.92021196  DT.100785873  DT.95327703  DT.121193033 

    Selected AceView cDNA sequences (see all 207):

    AI300352 CA306971 CD369829 NM_005276 CR593251 AI421485 CD515894 BM728256 
    AW473816 BP381824 BM701059 BM723668 AI640150 AI264177 T80809 BP334715 
    BM706386 BI759262 CA306021 BP381762 AA341745 BI758943 BP381755 H42536 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GPD1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14
    SP1:                    -     -           -     -                             -                                             
    SP2:                    -     -           -                                   -                                             
    SP3:                    -     -           -           -     -                 -                                             
    SP4:                    -                 -                                                                                 
    SP5:                                      -                 -     -                                                         


    ECgene alternative splicing isoforms for GPD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    GPD1 expression in normal human tissues (normalized intensities)      GPD1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGGCATCT
    GPD1 Expression
    About this image


    GPD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Kidney (Urinary System)    fully expand to see all 8 entries
             Loop of Henle Cells Loop of Henle
             Metanephros
     
     Adipose (Muscoskeletal System)    fully expand to see all 3 entries
             Body Subcutaneous White Adipose
             White adipocyte-like cells
     
     Epithelial Cells
             Loop of Henle Cells Loop of Henle
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     NULL (Uncategorized)
             Adipose-derived stromal vascular fraction and adipocytes (HiQCell)
    GPD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GPD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.524418
        Pathway & Disease-focused RT2 Profiler PCR Arrays including GPD1: 
              Insulin Signaling Pathway in human mouse rat
              Fatty Acid Metabolism in human mouse rat
              Diabetes in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
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    OriGene qSTAR qPCR primer pairs in human, mouse for GPD1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GPD1
    QuantiTect SYBR Green Assays in human, mouse, rat GPD1
    QuantiFast Probe-based Assays in human, mouse, rat GPD1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GPD1 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpd11 , 5 glycerol-3-phosphate dehydrogenase 1 (soluble)1, 5 89.59(n)1
    93.98(a)1
      15 (56.13 cM)5
    145551  NM_010271.21  NP_034401.11 
     997175155 
    chicken
    (Gallus gallus)
    Aves LOC4268811 glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic-like 75.26(n)
    79.37(a)
      426881  XM_003643117.2  XP_003643165.1 
    lizard
    (Anolis carolinensis)
    Reptilia GPD16
    glycerol-3-phosphate dehydrogenase 1 (soluble)
    84(a)
    1 ↔ 1
    2(91633778-91651523)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.24782 Xenopus laevis, Similar to glycerol phosphate dehydrogenase more 76.12(n)    BC043631.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc30a072 Danio rerio glycerol-3-phosphate dehydrogenase 1, mRNA more 78.01(n)    BC053116.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Gpdh1 , 3 glycerophosphate shuttle
    glycerol-3-phosphate more3
    Glycerol 3 phosphate dehydrogenase1
    65(a)
    (best of 2)3
    67.91(n)1
    66.67(a)1
      26A33
    338241  NM_057218.41  NP_476566.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F47G4.33
    gpdh-21
    NAD-dependent glycerol-3-phosphate
    dehydrogenase3
    gpdh-21
    50(a)3
    59.58(n)1
    61.78(a)1
      I(14083918-14086109)3
    1763991  NM_066787.41  NP_499188.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GPD1(YDL022W)4
    GPD11
    NAD-dependent glycerol-3-phosphate dehydrogenase, key more4
    GPD11
    53.47(n)1
    50.76(a)1
      4(411825-413000)4
    8515391, 4  NP_010262.11, 4 
    soybean
    (Glycine max)
    eudicotyledons 467530092   -- 77.16(n)  
    rice
    (Oryza sativa)
    Liliopsida Os.248912 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 76.79(n)    AK070366.1 


    ENSEMBL Gene Tree for GPD1 (if available)
    TreeFam Gene Tree for GPD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GPD1 gene
    GPD1L2  
    1 SIMAP similar gene for GPD1 using alignment to 2 protein entries:     GPDA_HUMAN (see all proteins):
    GPD1L

    GPD1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GPD1 (see all 197)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1438697201,2
    --47534240(+) CTCCTG/TTCCCA 2 -- int10--------
    rs765833911,2
    F--47534315(+) TGCCCA/GGGCTA 2 -- int13Minor allele frequency- G:0.08CSA WA 122
    rs1892115431,2
    --47534507(+) GGGTGC/TAGCAA 2 -- int10--------
    rs1816555041,2
    --47534531(+) GAGGCA/GGAAGT 2 -- int10--------
    rs22322081,2
    C,F,H--47534570(+) TCTCTT/CCTGCA 2 -- int1 trp39Minor allele frequency- C:0.04NS EA WA 1306
    rs1444162461,2
    F--47534685(+) GCCGTG/TGGGGC 4 V syn11Minor allele frequency- T:0.00NA 4550
    rs1410140441,2
    C--47534718(+) TTTGGC/TGACAA 4 G syn11Minor allele frequency- T:0.00NA 4552
    rs2010276311,2
    C--47534733(+) AAGGCG/AGCAGT 4 /A syn11Minor allele frequency- A:0.00MN 244
    rs349443861,2
    C--47534743(+) TGATCC/TGGCTG 4 R W mis13Minor allele frequency- T:0.01NA 80
    rs1996734551,2
    C--47534744(+) GATCCA/GGCTGG 4 Q R mis10--------

    HapMap Linkage Disequilibrium report for GPD1 (50497602 - 50505102 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for GPD1: --
    Human Gene Mutation Database (HGMD): GPD1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GPD1
    DNA2.0 Custom Variant and Variant Library Synthesis for GPD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 138420   
    OMIM disorders: 614480  
    UniProtKB/Swiss-Prot: GPDA_HUMAN, P21695
  • Hypertriglyceridemia, transient infantile (HTGTI) [MIM:614480]: An autosomal recessive disorder
    characterized by onset of moderate to severe transient hypertriglyceridemia in infancy that normalizes with age.
    The hypertriglyceridemia is associated with hepatomegaly, moderately elevated transaminases, persistent fatty
    liver, and the development of hepatic fibrosis. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • Selected diseases for GPD1 (see all 26):    About MalaCards
    hypertriglyceridemia, transient infantile    lactate dehydrogenase a deficiency    hypertriglyceridemia    brugada syndrome
    sleep apnea    liposarcoma    albinism    cleft palate
    cleft lip    duodenitis    obesity    blindness
    acute leukemia    myopathy    insulin resistance    pneumonia
    diabetes mellitus    tuberculosis    colorectal cancer    leukemia


    GPD1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    3 Novoseek inferred disease relationships for GPD1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 53.9 2 20404019 (1), 7857262 (1)
    necrosis 0.704 1 9492058 (1)
    tumors 0 1 9492058 (1)


    Export disorders for GPD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GPD1 gene, integrated from 10 sources (see all 193):
    (articles sorted by number of sources associating them with GPD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structures of human glycerol 3-phosphate dehydrogenase 1 (GPD1). (PubMed id 16460752)1, 2, 9 Ou X....Rao Z. (J. Mol. Biol. 2006)
    2. Sequence conservation and structural organization of the glycerol-3- phosphate dehydrogenase promoter in mice and humans. (PubMed id 2398890)1, 2, 9 Gwynn B.... Birkenmeier E.H. (Mol. Cell. Biol. 1990)
    3. Transient infantile hypertriglyceridemia, fatty liver, and hepatic fibrosis caused by mutated GPD1, encoding glycerol-3-phosphate dehydrogenase 1. (PubMed id 22226083)1, 2 Basel-Vanagaite L.... Shamir R. (Am. J. Hum. Genet. 2012)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Molecular cloning, sequencing and expression of a cDNA encoding a human liver NAD-dependent alpha-glycerol-3-phosphate dehydrogenase. (PubMed id 7772607)1, 2 Menaya J.... Ayuso M.S. (Biochim. Biophys. Acta 1995)
    6. The influence of obstructive sleep apnea on the expression of glycerol-3-phosphate dehydrogenase 1 gene. (PubMed id 20404019)1, 9 Guindalini C....Tufik S. (Exp. Biol. Med. (Maywood) 2010)
    7. Ability of cytosolic malate dehydrogenase and lactate dehydrogenase to increase the ratio of NADPH to NADH oxidation by cytosolic glycerol-3-phosphate dehydrogenase. (PubMed id 10190973)1, 9 Fahien L.A....Chobanian M. (Arch. Biochem. Biophys. 1999)
    8. GRB14, GPD1, and GDF8 as potential network collaborators in weight loss-induced improvements in insulin action in human skeletal muscle. (PubMed id 16849634)1, 9 Park J.J....Hoffman E.P. (Physiol. Genomics 2006)
    9. Enhanced glycerol 3-phosphate dehydrogenase activity in adipose tissue of obese humans. (PubMed id 14674682)1, 9 Swierczynski J....Sledzinski Z. (Mol. Cell. Biochem. 2003)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2819 HGNC: 4455 AceView: GPD1 Ensembl:ENSG00000167588 euGenes: HUgn2819
    ECgene: GPD1 Kegg: 2819 H-InvDB: GPD1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GPD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GPD1 gene:
    Search GeneIP for patents involving GPD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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