Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GPC5 Gene

Aliases for GPC5 Gene

  • Glypican 5 2 3 5
  • Glypican Proteoglycan 5 2 3
  • BA93M14.1 3

External Ids for GPC5 Gene

Previous GeneCards Identifiers for GPC5 Gene

  • GC13P090410
  • GC13P086438
  • GC13P090887
  • GC13P089749
  • GC13P089748
  • GC13P090848
  • GC13P092050
  • GC13P072646

Summaries for GPC5 Gene

Entrez Gene Summary for GPC5 Gene

  • Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPC5 Gene

GPC5 (Glypican 5) is a Protein Coding gene. Diseases associated with GPC5 include Simpson-Golabi-Behmel Syndrome and Tetralogy Of Fallot. Among its related pathways are Glycosaminoglycan metabolism and Defective B3GAT3 causes JDSSDHD. GO annotations related to this gene include heparan sulfate proteoglycan binding. An important paralog of this gene is GPC4.

UniProtKB/Swiss-Prot for GPC5 Gene

  • Cell surface proteoglycan that bears heparan sulfate.

Gene Wiki entry for GPC5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPC5 Gene

Genomics for GPC5 Gene

Regulatory Elements for GPC5 Gene

Enhancers for GPC5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPC5 on UCSC Golden Path with GeneCards custom track

Promoters for GPC5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPC5 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPC5 Gene

91,398,607 bp from pter
92,873,682 bp from pter
1,475,076 bases
Plus strand

Genomic View for GPC5 Gene

Genes around GPC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPC5 Gene

Proteins for GPC5 Gene

  • Protein details for GPC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2R726
    • O60436
    • Q9BX27

    Protein attributes for GPC5 Gene

    572 amino acids
    Molecular mass:
    63707 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPC5 Gene

Proteomics data for GPC5 Gene at MOPED

Post-translational modifications for GPC5 Gene

  • Glycosylation at Asn 120, Asn 237, Ser 441, Ser 486, Ser 495, Ser 507, Ser 509, and Asn 527
  • Modification sites at PhosphoSitePlus

Other Protein References for GPC5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPC5 Gene

Domains & Families for GPC5 Gene

Gene Families for GPC5 Gene

Protein Domains for GPC5 Gene


Suggested Antigen Peptide Sequences for GPC5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glypican family.
  • Belongs to the glypican family.
genes like me logo Genes that share domains with GPC5: view

Function for GPC5 Gene

Molecular function for GPC5 Gene

GENATLAS Biochemistry:
glypican 5,60kDa,extracellular proteoglycan,highly homolog with rat glypican OCI-5 expressed in fetal brain,lung and liver and adult brain,involved in the control of cellular response to growth factors and adhesion factors
UniProtKB/Swiss-Prot Function:
Cell surface proteoglycan that bears heparan sulfate.
genes like me logo Genes that share phenotypes with GPC5: view

Animal Models for GPC5 Gene

MGI Knock Outs for GPC5:
  • Gpc5 tm1a(KOMP)Wtsi

Animal Model Products

  • Taconic Biosciences Mouse Models for GPC5

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPC5 Gene

Localization for GPC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPC5 Gene

Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.
Secreted glypican-5: Secreted, extracellular space.

Subcellular locations from

Jensen Localization Image for GPC5 Gene COMPARTMENTS Subcellular localization image for GPC5 gene
Compartment Confidence
extracellular 5
lysosome 5
vacuole 5
golgi apparatus 4
plasma membrane 4
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for GPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane IEA,TAS --
genes like me logo Genes that share ontologies with GPC5: view

Pathways & Interactions for GPC5 Gene

genes like me logo Genes that share pathways with GPC5: view

Gene Ontology (GO) - Biological Process for GPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0030203 glycosaminoglycan metabolic process TAS --
genes like me logo Genes that share ontologies with GPC5: view

No data available for SIGNOR curated interactions for GPC5 Gene

Drugs & Compounds for GPC5 Gene

No Compound Related Data Available

Transcripts for GPC5 Gene

Unigene Clusters for GPC5 Gene

Glypican 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPC5 Gene

No ASD Table

Relevant External Links for GPC5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPC5 Gene

mRNA expression in normal human tissues for GPC5 Gene

mRNA differential expression in normal tissues according to GTEx for GPC5 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x7.7), Brain - Caudate (basal ganglia) (x7.0), Brain - Putamen (basal ganglia) (x6.2), and Brain - Amygdala (x5.4).

Protein differential expression in normal tissues from HIPED for GPC5 Gene

This gene is overexpressed in Pancreatic juice (57.7) and Frontal cortex (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPC5 Gene

SOURCE GeneReport for Unigene cluster for GPC5 Gene Hs.655675

mRNA Expression by UniProt/SwissProt for GPC5 Gene

Tissue specificity: In adult, primarily expressed in the brain. Also detected in fetal brain, lung and liver.
genes like me logo Genes that share expression patterns with GPC5: view

Protein tissue co-expression partners for GPC5 Gene

Primer Products

Orthologs for GPC5 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPC5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPC5 35
  • 88.09 (n)
  • 89.41 (a)
GPC5 36
  • 80 (a)
(Canis familiaris)
Mammalia GPC5 35
  • 87.27 (n)
  • 87.57 (a)
GPC5 36
  • 87 (a)
(Mus musculus)
Mammalia Gpc5 35
  • 84.85 (n)
  • 85.66 (a)
Gpc5 16
Gpc5 36
  • 86 (a)
(Pan troglodytes)
Mammalia GPC5 35
  • 99.07 (n)
  • 98.25 (a)
GPC5 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Gpc5 35
  • 83.86 (n)
  • 84.97 (a)
(Monodelphis domestica)
Mammalia GPC5 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia GPC5 36
  • 70 (a)
(Gallus gallus)
Aves GPC5 35
  • 74.74 (n)
  • 72.46 (a)
GPC5 36
  • 61 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 40 (a)
(Danio rerio)
Actinopterygii LOC559454 35
  • 58.5 (n)
  • 53.22 (a)
GPC5 36
  • 55 (a)
fruit fly
(Drosophila melanogaster)
Insecta dally 37
  • 28 (a)
dally 35
  • 42.84 (n)
  • 32.18 (a)
dally 36
  • 23 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005799 35
  • 40.86 (n)
  • 29.03 (a)
Species with no ortholog for GPC5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPC5 Gene

Gene Tree for GPC5 (if available)
Gene Tree for GPC5 (if available)

Paralogs for GPC5 Gene

Paralogs for GPC5 Gene

(2) SIMAP similar genes for GPC5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPC5: view

Variants for GPC5 Gene

Sequence variations from dbSNP and Humsavar for GPC5 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs553717 - 91,693,325(-) CATCC(A/G)CACCA reference, missense
rs16931 -- 92,188,567(+) GACCA(C/G)ATAAA intron-variant
rs17483 -- 91,558,187(+) aacaa(G/T)tcttg intron-variant
rs163728 -- 91,678,443(-) TTTCT(A/G)TTAGC intron-variant
rs163729 -- 91,735,989(-) TAATC(G/T)CAATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPC5 Gene

Variant ID Type Subtype PubMed ID
esv2747809 CNV Deletion 23290073
nsv826749 CNV Loss 20364138
esv2672717 CNV Deletion 23128226
esv2747810 CNV Deletion 23290073
nsv514714 CNV Complex 21397061
esv269253 CNV Insertion 20981092
esv272764 CNV Insertion 20981092
esv1383574 CNV Insertion 17803354
esv2662502 CNV Deletion 23128226
nsv900882 CNV Loss 21882294
esv267861 CNV Insertion 20981092
esv272705 CNV Insertion 20981092
esv1512558 CNV Insertion 17803354
esv2650286 CNV Deletion 19546169
esv2258713 CNV Deletion 18987734
esv2747811 CNV Deletion 23290073
esv1320980 CNV Deletion 17803354
nsv1120 CNV Loss 18451855
nsv527713 CNV Loss 19592680
dgv370e199 CNV Deletion 23128226
nsv498819 CNV Loss 21111241
esv21499 CNV Loss 19812545
esv2665629 CNV Deletion 23128226
nsv514715 CNV Loss 21397061
nsv524271 CNV Loss 19592680
nsv900883 CNV Loss 21882294
esv2674448 CNV Deletion 23128226
esv271090 CNV Insertion 20981092
esv272550 CNV Insertion 20981092
esv1107756 CNV Insertion 17803354
nsv900884 CNV Loss 21882294
esv2671333 CNV Deletion 23128226
dgv1774n71 CNV Loss 21882294
nsv528318 CNV Loss 19592680
esv28030 CNV Gain 19812545
esv2658739 CNV Deletion 23128226
dgv1775n71 CNV Loss 21882294
nsv900890 CNV Loss 21882294
nsv900892 CNV Gain 21882294
nsv900893 CNV Gain+Loss 21882294
nsv900895 CNV Loss 21882294
dgv1776n71 CNV Gain 21882294
nsv456066 CNV Gain 19166990
nsv900898 CNV Gain+Loss 21882294
dgv1777n71 CNV Loss 21882294
esv2678981 CNV Deletion 23128226
nsv900901 CNV Loss 21882294
esv274127 CNV Insertion 20981092
esv271349 CNV Insertion 20981092
esv267450 CNV Insertion 20981092
esv274518 CNV Insertion 20981092
esv2656933 CNV Deletion 23128226
nsv900902 CNV Gain 21882294
esv1606660 CNV Insertion 17803354
nsv527287 CNV Loss 19592680
nsv518324 CNV Loss 19592680
esv2672157 CNV Deletion 23128226
nsv456068 CNV Gain 19166990
nsv1122 CNV Insertion 18451855
nsv900903 CNV Loss 21882294
esv2747812 CNV Deletion 23290073
esv2747813 CNV Deletion 23290073
esv2668276 CNV Deletion 23128226
esv2677684 CNV Deletion 23128226
esv2659093 CNV Deletion 23128226
nsv832680 CNV Gain 17160897
dgv371e199 CNV Deletion 23128226
esv2747814 CNV Deletion 23290073
nsv1123 CNV Insertion 18451855
esv2664583 CNV Deletion 23128226
esv2547862 CNV Insertion 19546169
esv269792 CNV Insertion 20981092
esv272278 CNV Insertion 20981092
nsv471168 CNV Loss 18288195
dgv1778n71 CNV Loss 21882294
nsv456069 CNV Loss 19166990
esv2669187 CNV Deletion 23128226
nsv818987 CNV Loss 17921354
nsv1124 CNV Loss 18451855
esv2678676 CNV Deletion 23128226
esv2747815 CNV Deletion 23290073
esv28000 CNV Loss 19812545
nsv1125 CNV Insertion 18451855
nsv900906 CNV Loss 21882294
esv24496 CNV Gain 19812545
nsv521051 CNV Loss 19592680
nsv526003 CNV Loss 19592680
nsv456072 CNV Loss 19166990
esv2662445 CNV Deletion 23128226
nsv900907 CNV Loss 21882294

Variation tolerance for GPC5 Gene

Residual Variation Intolerance Score: 50.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.82; 86.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPC5 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPC5 Gene

Disorders for GPC5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GPC5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
simpson-golabi-behmel syndrome
  • bulldog syndrome
tetralogy of fallot
  • tetrology of fallot
- elite association - COSMIC cancer census association via MalaCards
Search GPC5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GPC5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GPC5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPC5 Gene

Publications for GPC5 Gene

  1. Genetic variants and risk of lung cancer in never smokers: a genome-wide association study. (PMID: 20304703) Li Y. … Yang P. (Lancet Oncol. 2010) 2 3 48 67
  2. Glypican 5 is an interferon-beta response gene: a replication study. (PMID: 19556317) CAcnit M.D. … MartA-nez A. (Mult. Scler. 2009) 2 3
  3. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 2 3
  4. GPC5 is a possible target for the 13q31-q32 amplification detected in lymphoma cell lines. (PMID: 12721791) Yu W. … Inazawa J. (J. Hum. Genet. 2003) 3 23
  5. A 4-Mb BAC/PAC contig and complete genomic structure of the GPC5/GPC6 gene cluster on chromosome 13q32. (PMID: 11566272) Veugelers M. … David G. (Matrix Biol. 2001) 3 23

Products for GPC5 Gene

Sources for GPC5 Gene