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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GPC4 Gene

protein-coding   GIFtS: 61
GCID: GC0XM132434

glypican 4
 Explore 8 diseases affiliated with
GPC4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for GPC4    

Aliases
for GPC4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Glypican 41 2
K-Glypican1
DJ900E8.1 (Glypican 4)2
Glypican Proteoglycan 42
Glypican-41

External Ids:    HGNC: 44521   Entrez Gene: 22392   Ensembl: ENSG000000767167   OMIM: 3001685   UniProtKB: O754873   

Export aliases for GPC4 gene to outside databases

Previous GC identifers: GC0XM127080 GC0XM129280 GC0XM130380 GC0XM131140 GC0XM132160 GC0XM132261 GC0XM121838


Summaries
for GPC4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for GPC4:
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a
variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family
(GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These
proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3'
end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: GPC4_HUMAN, O75487
Function: Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules
and of the central nervous system (By similarity)

Gene Wiki entry for GPC4 (Glypican 4)


Genomic Views
for GPC4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_011786.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GPC4 gene promoter:
         NF-1   NF-1/L   Pbx1a   GATA-3   AP-1   Meis-1b   Egr-4   GATA-1   GATA-2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GPC4 promoter sequence
   Search SABiosciences Chromatin IP Primers for GPC4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq26.1   Ensembl cytogenetic band:  Xq26.2   HGNC cytogenetic band: Xq26.1

GPC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPC4 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM132434:  view genomic region     (about GC identifiers)

Start:
 132,434,131 bp from pter      End:
 132,549,518 bp from pter
Size:
 115,388 bases      Orientation:
 minus strand

Proteins
for GPC4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: GPC4_HUMAN, O75487 (See protein sequence)
Recommended Name: Glypican-4 precursor  
Size: 556 amino acids; 62412 Da
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side (By similarity)
Subcellular location: Secreted glypican-4: Secreted, extracellular space (By similarity)
Secondary accessions: B2R6J7 Q6ZMA6 Q96L43 Q9NU08 Q9UJN1 Q9UPD9

Explore the universe of human proteins at neXtProt for GPC4: NX_O75487

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75487

    • GPC4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001439.2  
    ENSEMBL proteins: 
     ENSP00000359864   ENSP00000444959  
    Reactome Protein details: O75487
    Human Recombinant Protein Products: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for GPC4

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IEA--
    GO:0005796Golgi lumen TAS--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS9931407


    GPC4 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for GPC4

    Protein Domains /
    Families
    for GPC4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    GPC4 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR019803 Glypican_CS
     IPR001863 Glypican

    Graphical View of Domain Structure for InterPro Entry O75487

    ProtoNet protein and cluster: O75487

    1 Blocks protein family: IPB001863 Glypican

    UniProtKB/Swiss-Prot: GPC4_HUMAN, O75487
    Similarity: Belongs to the glypican family


    Function
    for GPC4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: GPC4_HUMAN, O75487
    Function: Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules
    and of the central nervous system (By similarity)

         Genatlas biochemistry entry for GPC4:
    glypican 4,K glypican,60kDa,putative extracellular proteoglycan,ubiquitously expressed,predominantly in fetal lung and
    kidney,involved in the control of cell division and growth regulation,juxtaposed to GPC3

    miRNA
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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate GPC4 (see all 17):
    hsa-miR-125a-5p hsa-miR-29b-1* hsa-miR-548a-3p hsa-miR-548g hsa-miR-125b hsa-miR-548x hsa-miR-205* hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmid: GPC4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GPC4 (see all 7)
    OriGene shRNA RFP: GPC4
    OriGene siRNA: GPC4
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    Gene Editing
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    Clone
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    Sino Biological Human cDNA Clone for GPC4
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GPC4 

    Cell Line
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    LifeMap BioReagents: cell lines associated with GPC4: PureStem ES-209, Meso-prx/latp Progenitor,
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPC4

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043395heparan sulfate proteoglycan binding IEA--


    GPC4 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for GPC4:
     Decreased Wnt reporter activit 

    Animal Models:
         Mouse knock-out Gpc4tm1Lex for GPC4
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Gpc4):
     hematopoietic system 

    GPC4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for GPC4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1MPS IIIC - Sanfilippo syndrome C
    8/16 pathways (see all 16)
    		MPS IIIC - Sanfilippo syndrome C1.00
    		MPS IIID - Sanfilippo syndrome D1.00
    		MPS I - Hurler syndrome1.00
    		MPS IX - Natowicz syndrome1.00
    		Mucopolysaccharidoses1.00
    		MPS II - Hunter syndrome1.00
    		MPS IV - Morquio syndrome A1.00
    		Glycosaminoglycan metabolism1.00
    2Retinoid metabolism and transport
    		Retinoid metabolism and transport1.00
    		Diseases associated with visual transduction0.73
    		Visual phototransduction0.74
    3HS-GAGs translocate to the lysosome for degradation
    		HS-GAGs translocate to the lysosome for degradation1.00
    		HS-GAG degradation0.57
    		Some HSPGs are secreted to the plasma membrane1.00
    4A tetrasaccharide linker sequence is required for GAG synthesis
    		A tetrasaccharide linker sequence is required for GAG synthesis1.00
    		Chondroitin sulfate/dermatan sulfate metabolism0.54
    5Disease
    		Disease1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/27        Reactome Pathways for GPC4 (see all 27)
        Diseases associated with visual transduction
    Chondroitin sulfate/dermatan sulfate metabolism
    MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    Visual phototransduction



    GPC4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GPC4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/46 Interacting proteins for GPC4 (O754873 ENSP000003598644) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SQSTM1Q135013, ENSP000003744554I2D: score=3 STRING: ENSP00000374455
    ACP5P136863, ENSP000002187584I2D: score=1 STRING: ENSP00000218758
    FGF2P090383, ENSP000002644984I2D: score=2 STRING: ENSP00000264498
    CCNCP248633I2D: score=1 
    FAM108A1Q96GS63I2D: score=1 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006024glycosaminoglycan biosynthetic process TAS--
    GO:0006027glycosaminoglycan catabolic process TAS--
    GO:0008283cell proliferation TAS9787072
    GO:0009653anatomical structure morphogenesis TAS9787072


    GPC4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for GPC4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GPC4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GPC4
    1 Novoseek chemical compound relationship for GPC4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heparan sulfate 54.4 1 9931407 (1)

    Search CenterWatch for drugs/clinical trials and news about GPC4 

    Transcripts
    for GPC4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for GPC4 gene: 
    NM_001448.2  

    Unigene Cluster for GPC4:

    Glypican 4
    Hs.58367  [show with all ESTs]
    Unigene Representative Sequence: AF030186
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370828(uc011mvg.1 uc004exc.1) ENST00000535467

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GPC4
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate GPC4 (see all 17):
    hsa-miR-125a-5p hsa-miR-29b-1* hsa-miR-548a-3p hsa-miR-548g hsa-miR-125b hsa-miR-548x hsa-miR-205* hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmid: GPC4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GPC4 (see all 7)
    OriGene shRNA RFP: GPC4
    OriGene siRNA: GPC4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GPC4
    Clone
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    GenScript: all cDNA clones in your preferred vector: GPC4 (NM_001448)
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    Primer
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    Additional cDNA sequence: 

    AF030186.1 AF064826.1 AF088063.1 AK304207.1 AK312605.1 AY052833.1 AY358507.1 BC017166.1 

    5 DOTS entries:

    DT.205743  DT.121323901  DT.121323884  DT.121323909  DT.435200 

    24/91 AceView cDNA sequences (see all 91):

    NM_001448 BM798989 AF088063 BC017166 AW237417 AA729686 AI908135 BF814892 
    BF057716 AY358507 AI492417 BE501034 AI908133 AU280056 W74526 AW594222 
    AA887423 AA933954 CD678102 AW242461 BE738902 BE827390 AI276057 BI966199 

    GeneLoc Exon Structure


    Expression
    for GPC4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GPC4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATGTTAATAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    GPC4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/13 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 13) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordSpinal Dorsal ColumnsDorsal Spinal Cord Progenitor CellsSpinal Cord
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BrainHypothalamusBrain
    BrainMedulla OblongataBrain
    KidneyMetanephrosKidney
    LimbAutopodLimb
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 7 LifeMap Cells 
    NameCategory
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    N2/LSB/S/F8-induced cells (Generation of midbra...)
    Definitive endoderm-like cells (A scalable, suspensi...)
    HyStem+TGF?3+GDF5-induced MEL2 cells (HyStem+TGF?3+GDF5 in...)Bone, Cartilage

    See GPC4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GPC4

    SOURCE GeneReport for Unigene cluster: Hs.58367
        SABiosciences Custom PCR Arrays for GPC4
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPC4

    Orthologs
    for GPC4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for GPC4 gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves GPC41 glypican 4 74.46(n)
    76.44(a)    		   422234  XM_420222.3  XP_420222.2 
    lizard
    (Anolis carolinensis)    		 Reptilia GPC46
    		 --
    		 72(a)
    		 1 ↔ 1
    		 GL344092.1(55759-68363)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.47202 Xenopus laevis Xgly4 mRNA for glypican-4, complete more 78.1(n)    AB082534.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii gpc41 glypican 4 61.87(n)
    58.32(a)    		   118437  NM_131860.2  NP_571935.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta dlp1 , 3 dally-like1 40(a)3
    49.93(n)1
    40.51(a)1    		   395961  NM_079347.21  NP_524071.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea gpn-11 Protein GPN-1 41.71(n)
    26.96(a)    		   181658  NM_078181.2  NP_510582.1 


    ENSEMBL Gene Tree for GPC4 (if available)
    TreeFam Gene Tree for GPC4 (if available) 

    Paralogs
    for GPC4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GPC4 gene
    GPC62  GPC32  GPC12  GPC22  GPC52  
    4 SIMAP similar genes for GPC4 using alignment to 3 protein entries:     GPC4_HUMAN (see all proteins):
    GPC6    GPC1    GPC2    GPC5

    GPC4 for paralogs           About GeneDecksing



    Genomic Variants
    for GPC4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1180 NCBI SNPs in GPC4 are shown (see all 1180)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1428285711,2
    		--132434607(+) TTCATA/GGTTGA 1 -- ds50010--------
    rs22394631,2
    		C,F,A,H,--132434985(+) TCCCTC/TATATA 1 -- ds5001 ese317Minor allele frequency- T:0.48NS EA NA WA CSA 1983
    rs2000876831,2
    		--132434997(+) AATGG-/AAGTGC 1 -- ds50010--------
    rs412990961,2
    		C,--132435030(+) ATTTGG/TTTTAA 1 -- ds50010--------
    rs1832328641,2
    		--132435033(+) TGTTTA/TAAAAA 1 -- ds50010--------
    rs413002031,2
    		C,--132435036(+) TTTAAA/GAAAAA 1 -- ds50010--------
    rs59753901,2
    		C,F,A,H,--132435044(+) AAAAAC/ACACTT 1 -- ds50016Minor allele frequency- A:0.47NS EA NA WA 418
    rs2011758061,2
    		--132435044(+) AAAAA-/CCACTT 1 -- ds50010--------
    rs777466851,2
    		C--132435398(+) CCTTTG/TAAAGT 1 -- ut310--------
    rs1509007621,2
    		--132435429(+) TTTTAC/TGAGCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for GPC4 (132434131 - 132549518 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for GPC4
         3 Indels: 83753 96979 96980
    Human Gene Mutation Database (HGMD): GPC4

    Locus Specific Mutation Databases (LSDB): GPC4

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GPC4
    DNA2.0 Custom Variant and Variant Library Synthesis for GPC4

    Disorders / Diseases
    for GPC4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    GPC4 for disorders           About GeneDecksing

    OMIM gene information: 300168    OMIM disorders: --

    8 diseases for GPC4:    About MalaCards
    simpson-golabi-behmel syndrome    postaxial polydactyly type a    polydactyly    overgrowth syndrome
    anoxia    ovarian carcinoma    carcinoma    postaxial polydactyly, type a2


    Export disorders for GPC4 gene to outside databases

    Publications
    for GPC4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GPC4 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with GPC4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. GPC4, the gene for human K-glypican, flanks GPC3 on Xq26: deletion of the GPC3-GPC4 gene cluster in one family with Simpson-Golabi-Behmel syndrome. (PubMed id 9787072)1, 2, 3, 9 Veugelers M....David G. (1998)
    2. Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss- of-function mutations in the GPC3 gene. (PubMed id 10814714)1, 2, 9 Veugelers M.... David G. (2000)
    3. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    6. Glypican 3 and glypican 4 are juxtaposed in Xq26.1. (PubMed id 9931407)1, 9 Huber R....Crisponi L. (1998)
    7. Expression of glypican-4 in haematopoietic-progenitor and bone-marrow-stromal cells. (PubMed id 10585884)1, 9 Siebertz B....Haubeck H.D. (1999)
    8. Modulating Glypican4 suppresses tumorigenicity of embr yonic stem cells while preserving self-renewal and pluripotency. (PubMed id 22761013)1 Fico A....Dono R. (2012)
    9. MicroRNA-125a inhibits cell growth by targeting glypic an-4. (PubMed id 22644326)1 Feng C....Ding K. (2012)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)

    External Searches for GPC4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    Genome Databases showing GPC4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2239 HGNC: 4452 AceView: GPC4 Ensembl:ENSG00000076716 euGenes: HUgn2239
    ECgene: GPC4 H-InvDB: GPC4

    Other Databases showing GPC4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing GPC4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GPC4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GPC4 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for GPC4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for GPC4 gene:
    Search GeneIP for patents involving GPC4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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     GPC4 Proteins, Antibodies, CLIAs, and ELISAs
     Cell Lines associated with GPC4: PureStem ES-209, Meso-prx/latp Progenitor,
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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