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Aliases for GPC4 Gene

Aliases for GPC4 Gene

  • Glypican 4 2 3
  • Glypican Proteoglycan 4 2 3
  • K-Glypican 3 4
  • DJ900E8.1 (Glypican 4) 3
  • Glypican-4 3

External Ids for GPC4 Gene

Previous GeneCards Identifiers for GPC4 Gene

  • GC0XM127080
  • GC0XM129280
  • GC0XM130380
  • GC0XM131140
  • GC0XM132160
  • GC0XM132261
  • GC0XM132434
  • GC0XM121838

Summaries for GPC4 Gene

Entrez Gene Summary for GPC4 Gene

  • Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPC4 Gene

GPC4 (Glypican 4) is a Protein Coding gene. Diseases associated with GPC4 include gpc4-related simpson-golabi-behmel syndrome type 1 and simpson-golabi-behmel syndrome, type 1. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include heparan sulfate proteoglycan binding. An important paralog of this gene is GPC5.

UniProtKB/Swiss-Prot for GPC4 Gene

  • Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity).

Gene Wiki entry for GPC4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPC4 Gene

Genomics for GPC4 Gene

Regulatory Elements for GPC4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GPC4 Gene

133,300,103 bp from pter
133,415,490 bp from pter
115,388 bases
Minus strand

Genomic View for GPC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPC4 Gene

Proteins for GPC4 Gene

  • Protein details for GPC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2R6J7
    • B4E2C0
    • Q6ZMA6
    • Q96L43
    • Q9NU08
    • Q9UJN1
    • Q9UPD9

    Protein attributes for GPC4 Gene

    556 amino acids
    Molecular mass:
    62412 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GPC4 Gene


neXtProt entry for GPC4 Gene

Proteomics data for GPC4 Gene at MOPED

Post-translational modifications for GPC4 Gene

  • Glycosylation at Thr375, Thr376, Ser494, Ser498, Ser500, and Asn514
  • Modification sites at PhosphoSitePlus

Other Protein References for GPC4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GPC4 Gene

Domains for GPC4 Gene

Gene Families for GPC4 Gene

  • GPC :Proteoglycans / Cell Surface : Glypicans

Protein Domains for GPC4 Gene


Suggested Antigen Peptide Sequences for GPC4 Gene

Graphical View of Domain Structure for InterPro Entry



  • O75487
  • Belongs to the glypican family.
genes like me logo Genes that share domains with GPC4: view

Function for GPC4 Gene

Molecular function for GPC4 Gene

GENATLAS Biochemistry: glypican 4,K glypican,60kDa,putative extracellular proteoglycan,ubiquitously expressed,predominantly in fetal lung and kidney,involved in the control of cell division and growth regulation,juxtaposed to GPC3
UniProtKB/Swiss-Prot Function: Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity).

Gene Ontology (GO) - Molecular Function for GPC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043395 heparan sulfate proteoglycan binding IEA --
genes like me logo Genes that share ontologies with GPC4: view

Phenotypes for GPC4 Gene

MGI mutant phenotypes for GPC4:
inferred from 1 alleles
GenomeRNAi human phenotypes for GPC4:
genes like me logo Genes that share phenotypes with GPC4: view

Animal Models for GPC4 Gene

MGI Knock Outs for GPC4:

Animal Model Products

miRNA for GPC4 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GPC4 Gene

Localization for GPC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPC4 Gene

Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.
Secreted glypican-4: Secreted, extracellular space.

Subcellular locations from

Jensen Localization Image for GPC4 Gene COMPARTMENTS Subcellular localization image for GPC4 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 4
lysosome 4
vacuole 4
extracellular 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GPC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IEA --
GO:0005634 nucleus IDA 21630459
GO:0005796 Golgi lumen TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with GPC4: view

Pathways for GPC4 Gene

genes like me logo Genes that share pathways with GPC4: view

Pathways by source for GPC4 Gene

Gene Ontology (GO) - Biological Process for GPC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0005975 carbohydrate metabolic process TAS --
GO:0006024 glycosaminoglycan biosynthetic process TAS --
GO:0006027 glycosaminoglycan catabolic process TAS --
GO:0007603 phototransduction, visible light TAS --
genes like me logo Genes that share ontologies with GPC4: view

Compounds for GPC4 Gene

(1) Novoseek inferred chemical compound relationships for GPC4 Gene

Compound -log(P) Hits PubMed IDs
heparan sulfate 54.4 1
genes like me logo Genes that share compounds with GPC4: view

Transcripts for GPC4 Gene

mRNA/cDNA for GPC4 Gene

(91) Selected AceView cDNA sequences:
(8) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPC4 Gene

Glypican 4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPC4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPC4 Gene

No ASD Table

Relevant External Links for GPC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPC4 Gene

mRNA expression in normal human tissues for GPC4 Gene

mRNA differential expression in normal tissues according to GTEx for GPC4 Gene

This gene is overexpressed in Esophagus - Muscularis (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GPC4 Gene

SOURCE GeneReport for Unigene cluster for GPC4 Gene Hs.58367

genes like me logo Genes that share expressions with GPC4: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GPC4 Gene

Orthologs for GPC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPC4 35
  • 99.94 (n)
  • 100 (a)
GPC4 36
  • 100 (a)
(Bos Taurus)
Mammalia GPC4 35
  • 89.93 (n)
  • 93.53 (a)
GPC4 36
  • 93 (a)
(Canis familiaris)
Mammalia GPC4 35
  • 91.25 (n)
  • 94.42 (a)
GPC4 36
  • 94 (a)
(Mus musculus)
Mammalia Gpc4 35
  • 90.83 (n)
  • 94.78 (a)
Gpc4 16
Gpc4 36
  • 95 (a)
(Monodelphis domestica)
Mammalia GPC4 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia GPC4 36
  • 83 (a)
(Rattus norvegicus)
Mammalia Gpc4 35
  • 89.75 (n)
  • 93.53 (a)
(Gallus gallus)
Aves GPC4 35
  • 74.9 (n)
  • 76.95 (a)
GPC4 36
  • 76 (a)
(Anolis carolinensis)
Reptilia GPC4 36
  • 69 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4720 35
tropical clawed frog
(Silurana tropicalis)
Amphibia gpc4 35
  • 72.13 (n)
  • 75.43 (a)
Str.10144 35
(Danio rerio)
Actinopterygii gpc4 35
  • 62.45 (n)
  • 59.2 (a)
gpc4 36
  • 56 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003559 35
  • 51.68 (n)
  • 41.06 (a)
fruit fly
(Drosophila melanogaster)
Insecta dlp 35
  • 50.86 (n)
  • 41.82 (a)
dlp 36
  • 26 (a)
dlp 37
  • 40 (a)
(Caenorhabditis elegans)
Secernentea gpn-1 35
  • 43.03 (n)
  • 27.3 (a)
gpn-1 36
  • 23 (a)
Species with no ortholog for GPC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPC4 Gene

Gene Tree for GPC4 (if available)
Gene Tree for GPC4 (if available)

Paralogs for GPC4 Gene

Paralogs for GPC4 Gene

Selected SIMAP similar genes for GPC4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GPC4: view

Variants for GPC4 Gene

Sequence variations from dbSNP and Humsavar for GPC4 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1048369 - 133,303,309(-) ATTAG(C/T)CAACC reference, missense
rs1129980 - 133,304,844(-) AAGGA(G/T)AAACT reference, missense
rs1883664 -- 133,328,921(+) TTTGA(C/G)AGGTG intron-variant
rs2073049 -- 133,304,980(+) TTTCA(A/C)CTTTA intron-variant
rs2073050 -- 133,311,716(+) CACAC(A/T)CATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPC4 Gene

Variant ID Type Subtype PubMed ID
nsv7100 CNV Insertion 18451855

Relevant External Links for GPC4 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPC4 Gene

Disorders for GPC4 Gene

Relevant External Links for GPC4

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with GPC4: view

No data available for UniProtKB/Swiss-Prot for GPC4 Gene

Publications for GPC4 Gene

  1. GPC4, the gene for human K-glypican, flanks GPC3 on Xq26: deletion of the GPC3-GPC4 gene cluster in one family with Simpson-Golabi-Behmel syndrome. (PMID: 9787072) Veugelers M. … David G. (Genomics 1998) 2 3 4 23
  2. Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss- of-function mutations in the GPC3 gene. (PMID: 10814714) Veugelers M. … David G. (Hum. Mol. Genet. 2000) 3 4 23
  3. Glypican 3 and glypican 4 are juxtaposed in Xq26.1. (PMID: 9931407) Huber R. … Crisponi L. (Gene 1998) 3 23
  4. Expression of glypican-4 in haematopoietic-progenitor and bone-marrow-stromal cells. (PMID: 10585884) Siebertz B. … Haubeck H.D. (Biochem. J. 1999) 3 23
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4

Products for GPC4 Gene

Sources for GPC4 Gene

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