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Aliases for GPC4 Gene

Aliases for GPC4 Gene

  • Glypican 4 2 3 5
  • Glypican Proteoglycan 4 2 3
  • K-Glypican 3 4
  • DJ900E8.1 (Glypican 4) 3

External Ids for GPC4 Gene

Previous GeneCards Identifiers for GPC4 Gene

  • GC0XM127080
  • GC0XM129280
  • GC0XM130380
  • GC0XM131140
  • GC0XM132160
  • GC0XM132261
  • GC0XM132434
  • GC0XM121838

Summaries for GPC4 Gene

Entrez Gene Summary for GPC4 Gene

  • Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPC4 Gene

GPC4 (Glypican 4) is a Protein Coding gene. Diseases associated with GPC4 include Gpc4-Related Simpson-Golabi-Behmel Syndrome Type 1 and Simpson-Golabi-Behmel Syndrome, Type 1. Among its related pathways are Glycosaminoglycan metabolism and Defective B3GAT3 causes JDSSDHD. GO annotations related to this gene include heparan sulfate proteoglycan binding. An important paralog of this gene is GPC5.

UniProtKB/Swiss-Prot for GPC4 Gene

  • Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity).

Gene Wiki entry for GPC4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPC4 Gene

Genomics for GPC4 Gene

Regulatory Elements for GPC4 Gene

Enhancers for GPC4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPC4 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPC4 Gene

133,300,103 bp from pter
133,415,490 bp from pter
115,388 bases
Minus strand

Genomic View for GPC4 Gene

Genes around GPC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPC4 Gene

Proteins for GPC4 Gene

  • Protein details for GPC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2R6J7
    • B4E2C0
    • Q6ZMA6
    • Q96L43
    • Q9NU08
    • Q9UJN1
    • Q9UPD9

    Protein attributes for GPC4 Gene

    556 amino acids
    Molecular mass:
    62412 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GPC4 Gene


neXtProt entry for GPC4 Gene

Proteomics data for GPC4 Gene at MOPED

Post-translational modifications for GPC4 Gene

  • Glycosylation at Thr 375, Ser 494, Ser 498, Ser 500, and Asn 514
  • Modification sites at PhosphoSitePlus

Other Protein References for GPC4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GPC4 Gene

Domains & Families for GPC4 Gene

Gene Families for GPC4 Gene

Protein Domains for GPC4 Gene


Suggested Antigen Peptide Sequences for GPC4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glypican family.
  • Belongs to the glypican family.
genes like me logo Genes that share domains with GPC4: view

Function for GPC4 Gene

Molecular function for GPC4 Gene

GENATLAS Biochemistry:
glypican 4,K glypican,60kDa,putative extracellular proteoglycan,ubiquitously expressed,predominantly in fetal lung and kidney,involved in the control of cell division and growth regulation,juxtaposed to GPC3
UniProtKB/Swiss-Prot Function:
Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity).
genes like me logo Genes that share phenotypes with GPC4: view

Human Phenotype Ontology for GPC4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for GPC4 Gene

MGI Knock Outs for GPC4:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPC4

miRNA for GPC4 Gene

miRTarBase miRNAs that target GPC4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for GPC4 Gene

Localization for GPC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPC4 Gene

Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.
Secreted glypican-4: Secreted, extracellular space.

Subcellular locations from

Jensen Localization Image for GPC4 Gene COMPARTMENTS Subcellular localization image for GPC4 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
nucleus 5
plasma membrane 5
lysosome 4
vacuole 4
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GPC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
genes like me logo Genes that share ontologies with GPC4: view

Pathways & Interactions for GPC4 Gene

genes like me logo Genes that share pathways with GPC4: view

SIGNOR curated interactions for GPC4 Gene


Gene Ontology (GO) - Biological Process for GPC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0008283 cell proliferation TAS 9787072
GO:0060071 Wnt signaling pathway, planar cell polarity pathway NAS 24431302
genes like me logo Genes that share ontologies with GPC4: view

Drugs & Compounds for GPC4 Gene

(1) Additional Compounds for GPC4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GPC4: view

Transcripts for GPC4 Gene

mRNA/cDNA for GPC4 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(91) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPC4 Gene

Glypican 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPC4 Gene

No ASD Table

Relevant External Links for GPC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPC4 Gene

mRNA expression in normal human tissues for GPC4 Gene

mRNA differential expression in normal tissues according to GTEx for GPC4 Gene

This gene is overexpressed in Esophagus - Muscularis (x4.0).

Protein differential expression in normal tissues from HIPED for GPC4 Gene

This gene is overexpressed in Placenta (12.0) and Pancreas (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPC4 Gene

SOURCE GeneReport for Unigene cluster for GPC4 Gene Hs.58367

genes like me logo Genes that share expression patterns with GPC4: view

Protein tissue co-expression partners for GPC4 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for GPC4 Gene

Orthologs for GPC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPC4 35
  • 89.93 (n)
  • 93.53 (a)
GPC4 36
  • 93 (a)
(Canis familiaris)
Mammalia GPC4 35
  • 91.25 (n)
  • 94.42 (a)
GPC4 36
  • 94 (a)
(Mus musculus)
Mammalia Gpc4 35
  • 90.83 (n)
  • 94.78 (a)
Gpc4 16
Gpc4 36
  • 95 (a)
(Pan troglodytes)
Mammalia GPC4 35
  • 99.94 (n)
  • 100 (a)
GPC4 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Gpc4 35
  • 89.75 (n)
  • 93.53 (a)
(Monodelphis domestica)
Mammalia GPC4 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia GPC4 36
  • 83 (a)
(Gallus gallus)
Aves GPC4 35
  • 74.9 (n)
  • 76.95 (a)
GPC4 36
  • 76 (a)
(Anolis carolinensis)
Reptilia GPC4 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpc4 35
  • 72.13 (n)
  • 75.43 (a)
Str.10144 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.4720 35
(Danio rerio)
Actinopterygii gpc4 35
  • 62.45 (n)
  • 59.2 (a)
gpc4 36
  • 56 (a)
fruit fly
(Drosophila melanogaster)
Insecta dlp 37
  • 40 (a)
dlp 35
  • 50.86 (n)
  • 41.82 (a)
dlp 36
  • 26 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003559 35
  • 51.68 (n)
  • 41.06 (a)
(Caenorhabditis elegans)
Secernentea gpn-1 35
  • 43.03 (n)
  • 27.3 (a)
gpn-1 36
  • 23 (a)
Species with no ortholog for GPC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPC4 Gene

Gene Tree for GPC4 (if available)
Gene Tree for GPC4 (if available)

Paralogs for GPC4 Gene

Paralogs for GPC4 Gene

(4) SIMAP similar genes for GPC4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GPC4: view

Variants for GPC4 Gene

Sequence variations from dbSNP and Humsavar for GPC4 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1129980 - 133,304,844(-) AAGGA(G/T)AAACT reference, missense
rs1048369 - 133,303,309(-) ATTAG(C/T)CAACC reference, missense
rs747713932 -- 133,340,016(+) GTGTA(C/T)GTAGC intron-variant
rs747737509 -- 133,375,032(+) CACTT(A/C)CACAT intron-variant
rs747740292 -- 133,306,701(+) TCTAA(C/T)GACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPC4 Gene

Variant ID Type Subtype PubMed ID
nsv7100 CNV Insertion 18451855

Variation tolerance for GPC4 Gene

Residual Variation Intolerance Score: 22.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.05; 97.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPC4 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPC4 Gene

Disorders for GPC4 Gene

MalaCards: The human disease database

(5) MalaCards diseases for GPC4 Gene - From: GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
gpc4-related simpson-golabi-behmel syndrome type 1
  • gpc4-related sgbs1
simpson-golabi-behmel syndrome, type 1
  • bulldog syndrome
simpson-golabi-behmel syndrome
  • bulldog syndrome
postaxial polydactyly, type a2
perlman syndrome
  • nephroblastomatosis - fetal ascites - macrosomia - wilms tumor
- elite association - COSMIC cancer census association via MalaCards
Search GPC4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GPC4

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GPC4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPC4 Gene

Publications for GPC4 Gene

  1. GPC4, the gene for human K-glypican, flanks GPC3 on Xq26: deletion of the GPC3-GPC4 gene cluster in one family with Simpson-Golabi-Behmel syndrome. (PMID: 9787072) Veugelers M. … David G. (Genomics 1998) 2 3 4 23 67
  2. Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss- of-function mutations in the GPC3 gene. (PMID: 10814714) Veugelers M. … David G. (Hum. Mol. Genet. 2000) 3 23
  3. Expression of glypican-4 in haematopoietic-progenitor and bone-marrow-stromal cells. (PMID: 10585884) Siebertz B. … Haubeck H.D. (Biochem. J. 1999) 3 23
  4. Glypican 3 and glypican 4 are juxtaposed in Xq26.1. (PMID: 9931407) Huber R. … Crisponi L. (Gene 1998) 3 23
  5. Reversible oxidation of phosphatase and tensin homolog (PTEN) alters its interactions with signaling and regulatory proteins. (PMID: 26561776) Verrastro I. … Pitt A.R. (Free Radic. Biol. Med. 2016) 3

Products for GPC4 Gene

Sources for GPC4 Gene