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GPC4 Gene

protein-coding   GIFtS: 65
GCID: GC0XM132434

Glypican 4

  See GPC4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glypican 41 2
Glypican Proteoglycan 41 2
K-glypican2 3
DJ900E8.1 (Glypican 4)2
glypican-42

External Ids:    HGNC: 44521   Entrez Gene: 22392   Ensembl: ENSG000000767167   OMIM: 3001685   UniProtKB: O754873   

Export aliases for GPC4 gene to outside databases

Previous GC identifers: GC0XM127080 GC0XM129280 GC0XM130380 GC0XM131140 GC0XM132160 GC0XM132261 GC0XM121838


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GPC4 Gene:
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a
variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family
(GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage.
These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent
to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome. (provided by RefSeq, Jul 2008)

GeneCards Summary for GPC4 Gene:
GPC4 (glypican 4) is a protein-coding gene. Diseases associated with GPC4 include gpc4-related simpson-golabi-behmel syndrome type 1, and simpson-golabi-behmel syndrome type 1. GO annotations related to this gene include heparan sulfate proteoglycan binding. An important paralog of this gene is GPC6.

UniProtKB/Swiss-Prot: GPC4_HUMAN, O75487
Function: Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney
tubules and of the central nervous system (By similarity)

Gene Wiki entry for GPC4 (Glypican 4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_011786.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the GPC4 gene promoter:
         NF-1   NF-1/L   Pbx1a   GATA-3   AP-1   Meis-1b   Egr-4   GATA-1   GATA-2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPC4 promoter sequence
   Search Chromatin IP Primers for GPC4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GPC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq26.1   Ensembl cytogenetic band:  Xq26.2   HGNC cytogenetic band: Xq26.1

GPC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPC4 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM132434:  view genomic region     (about GC identifiers)

Start:
132,434,131 bp from pter      End:
132,549,518 bp from pter
Size:
115,388 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GPC4_HUMAN, O75487 (See protein sequence)
Recommended Name: Glypican-4 precursor  
Size: 556 amino acids; 62412 Da
Secondary accessions: B2R6J7 Q6ZMA6 Q96L43 Q9NU08 Q9UJN1 Q9UPD9

Explore the universe of human proteins at neXtProt for GPC4: NX_O75487

Explore proteomics data for GPC4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Thr375, Thr376, Ser494, Ser498, Ser500, Asn514
  • Modification sites at PhosphoSitePlus

  • See GPC4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001439.2  
    ENSEMBL proteins: 
     ENSP00000359864   ENSP00000444959  
    Reactome Protein details: O75487

    GPC4 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for GPC4

     
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    antibodies-online proteins for GPC4 (7 products) 

     
    antibodies-online peptides for GPC4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GPC: Proteoglycans / Cell Surface : Glypicans

    2 InterPro protein domains:
     IPR019803 Glypican_CS
     IPR001863 Glypican

    Graphical View of Domain Structure for InterPro Entry O75487

    ProtoNet protein and cluster: O75487

    1 Blocks protein domain: IPB001863 Glypican

    UniProtKB/Swiss-Prot: GPC4_HUMAN, O75487
    Similarity: Belongs to the glypican family


    Find genes that share domains with GPC4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GPC4_HUMAN, O75487
    Function: Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney
    tubules and of the central nervous system (By similarity)

         Genatlas biochemistry entry for GPC4:
    glypican 4,K glypican,60kDa,putative extracellular proteoglycan,ubiquitously expressed,predominantly in fetal lung
    and kidney,involved in the control of cell division and growth regulation,juxtaposed to GPC3

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043395heparan sulfate proteoglycan binding IEA--
         
    Find genes that share ontologies with GPC4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GPC4:
     Decreased Wnt reporter activit 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Gpc4):
     hematopoietic system 

    Find genes that share phenotypes with GPC4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Gpc4tm1Lex for GPC4

       genOway: Develop your customized and physiologically relevant rodent model for GPC4

    miRNA
    Products:
        
    miRTarBase miRNAs that target GPC4:
    hsa-mir-142-3p (MIRT021567), hsa-mir-26b-5p (MIRT029649), hsa-mir-192-5p (MIRT026559), hsa-mir-215-5p (MIRT024432)

    Block miRNA regulation of human, mouse, rat GPC4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GPC4 (see all 17):
    hsa-miR-125a-5p hsa-miR-29b-1* hsa-miR-548a-3p hsa-miR-548g hsa-miR-125b hsa-miR-548x hsa-miR-205* hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidGPC4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GPC4
    Predesigned siRNA for gene silencing in human, mouse, rat GPC4

    Gene Editing
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    Sino Biological Human cDNA Clone for GPC4
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPC4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GPC4_HUMAN, O75487: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side (By similarity)
    GPC4_HUMAN, O75487: Secreted glypican-4: Secreted, extracellular space (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    golgi apparatus4
    lysosome4
    vacuole4
    extracellular2
    endoplasmic reticulum1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IEA--
    GO:0005796Golgi lumen TAS--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9931407

    Find genes that share ontologies with GPC4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GPC4 About   (see all 8)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIIB - Sanfilippo syndrome B0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS II - Hunter syndrome0.45
    MPS IV - Morquio syndrome A0.45
    Glycosaminoglycan metabolism0.45
    Mucopolysaccharidoses0.45
    MPS IV - Morquio syndrome B0.45
    2Heparan sulfate/heparin (HS-GAG) metabolism
    Heparan sulfate/heparin (HS-GAG) metabolism0.57
    HS-GAG degradation0.39
    HS-GAG biosynthesis0.57
    3Diseases associated with visual transduction
    Visual phototransduction0.44
    Diseases associated with visual transduction0.43
    Retinoid metabolism and transport0.44
    4Chondroitin sulfate/dermatan sulfate metabolism
    Chondroitin sulfate/dermatan sulfate metabolism0.51
    A tetrasaccharide linker sequence is required for GAG synthesis0.51
    5Signaling by GPCR
    Signal Transduction0.58


    Find genes that share SuperPaths with GPC4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    4 Reactome Pathways for GPC4
        HS-GAG biosynthesis
    Retinoid metabolism and transport
    HS-GAG degradation
    A tetrasaccharide linker sequence is required for GAG synthesis


    1 Kegg Pathway  (Kegg details for GPC4):
        Wnt signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GPC4
    Interactions:

        GeneGlobe Interaction Network for GPC4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GPC4 (O754873 ENSP000003598644) via UniProtKB, MINT, STRING, and/or I2D (see all 65)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SQSTM1Q135013, ENSP000003744554I2D: score=3 STRING: ENSP00000374455
    ACP5P136863, ENSP000002187584I2D: score=1 STRING: ENSP00000218758
    FGF2P090383, ENSP000002644984I2D: score=2 STRING: ENSP00000264498
    ABHD17AQ96GS63I2D: score=1 
    CCNCP248633I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001523retinoid metabolic process TAS--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006024glycosaminoglycan biosynthetic process TAS--
    GO:0006027glycosaminoglycan catabolic process TAS--
    GO:0007603phototransduction, visible light TAS--

    Find genes that share ontologies with GPC4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GPC4

    1 Novoseek inferred chemical compound relationship for GPC4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heparan sulfate 54.4 1 9931407 (1)



    Find genes that share compounds with GPC4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GPC4 gene: 
    NM_001448.2  

    Unigene Cluster for GPC4:

    Glypican 4
    Hs.58367  [show with all ESTs]
    Unigene Representative Sequence: AF030186
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370828(uc011mvg.1 uc004exc.1) ENST00000535467
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate GPC4 (see all 17):
    hsa-miR-125a-5p hsa-miR-29b-1* hsa-miR-548a-3p hsa-miR-548g hsa-miR-125b hsa-miR-548x hsa-miR-205* hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidGPC4 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat GPC4
      QuantiFast Probe-based Assays in human, mouse, rat GPC4

    Additional mRNA sequence: 

    AF030186.1 AF064826.1 AF088063.1 AK304207.1 AK312605.1 AY052833.1 AY358507.1 BC017166.1 

    5 DOTS entries:

    DT.205743  DT.121323901  DT.121323884  DT.121323909  DT.435200 

    Selected AceView cDNA sequences (see all 91):

    NM_001448 W74526 AF088063 AI908133 AW594222 BE501034 AU280056 BF814892 
    AY358507 AI908135 BF057716 AA729686 BM798989 AA887423 AW237417 BC017166 
    AI492417 AI651668 CD678102 BM769845 BM744563 BE738902 AW004634 BG679593 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GPC4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTTAATAA
    GPC4 Expression
    About this image


    GPC4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 6 entries
             Metencephalon
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Bone marrow-derived mesenchymal stem cells
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebellum
             N2/LSB/S/F8-induced cells
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle
    GPC4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GPC4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.58367
        Custom PCR Arrays for GPC4
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPC4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GPC4 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpc41 , 5 glypican 41, 5 90.83(n)1
    94.78(a)1
      X (28.33 cM)5
    147351  NM_008150.21  NP_032176.21 
     520530215 
    chicken
    (Gallus gallus)
    Aves GPC41 glypican 4 74.9(n)
    76.95(a)
      422234  XM_420222.4  XP_420222.3 
    lizard
    (Anolis carolinensis)
    Reptilia GPC46
    glypican 4
    69(a)
    1 ↔ 1
    GL344092.1(55759-69276)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.47202 Xenopus laevis Xgly4 mRNA for glypican-4, complete more 78.1(n)    AB082534.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gpc41 glypican 4 62.45(n)
    59.2(a)
      118437  NM_131860.2  NP_571935.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta dlp1 , 3 dally-like1 40(a)3
    50.86(n)1
    41.82(a)1
      395961  NM_206353.21  NP_996075.21 
    worm
    (Caenorhabditis elegans)
    Secernentea gpn-11 gpn-1 43.03(n)
    27.3(a)
      181658  NM_078181.3  NP_510582.1 


    ENSEMBL Gene Tree for GPC4 (if available)
    TreeFam Gene Tree for GPC4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GPC4 gene
    GPC62  GPC32  GPC12  GPC22  GPC52  
    4 SIMAP similar genes for GPC4 using alignment to 3 protein entries:     GPC4_HUMAN (see all proteins):
    GPC6    GPC1    GPC2    GPC5

    Find genes that share paralogs with GPC4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GPC4 (see all 1438)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1428285711,2
    C--132391713(+) TTCATA/GGTTGA 1 -- ds50010--------
    rs22394631,2
    C,F,A,H--132392091(+) TCCCTC/TATATA 1 -- ds5001 ese317Minor allele frequency- T:0.48NS EA NA WA CSA 1983
    rs2000876831,2
    --132392103(+) AATGG-/AAGTGC 1 -- ds50010--------
    rs412990961,2
    C--132392136(+) ATTTGG/TTTTAA 1 -- ds50010--------
    rs1832328641,2
    --132392139(+) TGTTTA/TAAAAA 1 -- ds50010--------
    rs413002031,2
    C--132392142(+) TTTAAA/GAAAAA 1 -- ds50010--------
    rs59753901,2
    C,F,A,H--132392150(+) AAAAAC/ACACTT 1 -- ds50016Minor allele frequency- A:0.47NS EA NA WA 418
    rs2011758061,2
    --132392150(+) AAAAA-/CCACTT 1 -- ds50010--------
    rs777466851,2
    C--132392504(+) CCTTTG/TAAAGT 1 -- ut310--------
    rs1509007621,2
    --132392535(+) TTTTAC/TGAGCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for GPC4 (132434131 - 132549518 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for GPC4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7100CNV Insertion18451855

    Human Gene Mutation Database (HGMD): GPC4
    Locus Specific Mutation Databases (LSDB): GPC4

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GPC4
    DNA2.0 Custom Variant and Variant Library Synthesis for GPC4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300168    OMIM disorders: --

    6 diseases for GPC4:    
    About MalaCards
    gpc4-related simpson-golabi-behmel syndrome type 1    simpson-golabi-behmel syndrome type 1    postaxial polydactyly, type a2    simpson-golabi-behmel syndrome
    postaxial polydactyly type a    anoxia


    Find genes that share disorders with GPC4           About GenesLikeMe

    Genetic Association Database (GAD): GPC4

    Export disorders for GPC4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GPC4 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with GPC4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. GPC4, the gene for human K-glypican, flanks GPC3 on Xq26: deletion of the GPC3-GPC4 gene cluster in one family with Simpson-Golabi-Behmel syndrome. (PubMed id 9787072)1, 2, 3, 9 Veugelers M....David G. (Genomics 1998)
    2. Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss- of-function mutations in the GPC3 gene. (PubMed id 10814714)1, 2, 9 Veugelers M.... David G. (Hum. Mol. Genet. 2000)
    3. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. Glypican 3 and glypican 4 are juxtaposed in Xq26.1. (PubMed id 9931407)1, 9 Huber R....Crisponi L. (Gene 1998)
    7. Expression of glypican-4 in haematopoietic-progenitor and bone-marrow-stromal cells. (PubMed id 10585884)1, 9 Siebertz B....Haubeck H.D. (Biochem. J. 1999)
    8. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    9. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    10. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2239 HGNC: 4452 AceView: GPC4 Ensembl:ENSG00000076716 euGenes: HUgn2239
    ECgene: GPC4 Kegg: 2239 H-InvDB: GPC4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for GPC4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GPC4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for GPC4 gene:
    Search GeneIP for patents involving GPC4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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