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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GPC4 Gene

protein-coding   GIFtS: 64
GCID: GC0XM132434

Glypican 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Glypican 41 2
Glypican Proteoglycan 41 2
K-glypican2 3
DJ900E8.1 (Glypican 4)2
glypican-42

External Ids:    HGNC: 44521   Entrez Gene: 22392   Ensembl: ENSG000000767167   OMIM: 3001685   UniProtKB: O754873   

Export aliases for GPC4 gene to outside databases

Previous GC identifers: GC0XM127080 GC0XM129280 GC0XM130380 GC0XM131140 GC0XM132160 GC0XM132261 GC0XM121838


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GPC4 Gene:
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a
variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family
(GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage.
These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent
to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome. (provided by RefSeq, Jul 2008)

GeneCards Summary for GPC4 Gene: 
GPC4 (glypican 4) is a protein-coding gene. Diseases associated with GPC4 include gpc4-related simpson-golabi-behmel syndrome type 1, and simpson-golabi-behmel syndrome type 1, and among its related super-pathways are Metabolism of carbohydrates and Heparan sulfate/heparin (HS-GAG) metabolism. GO annotations related to this gene include heparan sulfate proteoglycan binding. An important paralog of this gene is GPC6.

UniProtKB/Swiss-Prot: GPC4_HUMAN, O75487
Function: Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney
tubules and of the central nervous system (By similarity)

Gene Wiki entry for GPC4 (Glypican 4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011786.16  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GPC4 gene promoter:
         NF-1   NF-1/L   Pbx1a   GATA-3   AP-1   Meis-1b   Egr-4   GATA-1   GATA-2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPC4 promoter sequence
   Search SABiosciences Chromatin IP Primers for GPC4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GPC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq26.1   Ensembl cytogenetic band:  Xq26.2   HGNC cytogenetic band: Xq26.1

GPC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPC4 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM132434:  view genomic region     (about GC identifiers)

Start:
132,434,131 bp from pter      End:
132,549,518 bp from pter
Size:
115,388 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GPC4_HUMAN, O75487 (See protein sequence)
Recommended Name: Glypican-4 precursor  
Size: 556 amino acids; 62412 Da
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side (By similarity)
Subcellular location: Secreted glypican-4: Secreted, extracellular space (By similarity)
Secondary accessions: B2R6J7 Q6ZMA6 Q96L43 Q9NU08 Q9UJN1 Q9UPD9

Explore the universe of human proteins at neXtProt for GPC4: NX_O75487

Explore proteomics data for GPC4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75487

  • GPC4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GPC4 Protein Expression
    REFSEQ proteins: NP_001439.2  
    ENSEMBL proteins: 
     ENSP00000359864   ENSP00000444959  
    Reactome Protein details: O75487
    Human Recombinant Protein Products for GPC4: 
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    Cloud-Clone Corp. Proteins for GPC4 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IEA--
    GO:0005796Golgi lumen TAS--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS9931407

    GPC4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    GPC: Proteoglycans / Cell Surface : Glypicans

    2 InterPro protein domains:
     IPR019803 Glypican_CS
     IPR001863 Glypican

    Graphical View of Domain Structure for InterPro Entry O75487

    ProtoNet protein and cluster: O75487

    1 Blocks protein domain: IPB001863 Glypican

    UniProtKB/Swiss-Prot: GPC4_HUMAN, O75487
    Similarity: Belongs to the glypican family


    GPC4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GPC4_HUMAN, O75487
    Function: Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney
    tubules and of the central nervous system (By similarity)

         Genatlas biochemistry entry for GPC4:
    glypican 4,K glypican,60kDa,putative extracellular proteoglycan,ubiquitously expressed,predominantly in fetal lung
    and kidney,involved in the control of cell division and growth regulation,juxtaposed to GPC3

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043395heparan sulfate proteoglycan binding IEA--
         
    GPC4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GPC4:
     Decreased Wnt reporter activit 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Gpc4):
     hematopoietic system 

    GPC4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Gpc4tm1Lex for GPC4

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GPC4 
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    SwitchGear 3'UTR luciferase reporter plasmidGPC4 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPC4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GPC4 About   (see all 8)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MPS IIIC - Sanfilippo syndrome C
    MPS IIIC - Sanfilippo syndrome C0.48
    Glycosaminoglycan metabolism0.48
    MPS IV - Morquio syndrome A0.48
    MPS IIID - Sanfilippo syndrome D0.48
    MPS VI - Maroteaux-Lamy syndrome0.48
    MPS I - Hurler syndrome0.48
    MPS IV - Morquio syndrome B0.48
    MPS IX - Natowicz syndrome0.48
    2Heparan sulfate/heparin (HS-GAG) metabolism
    Heparan sulfate/heparin (HS-GAG) metabolism0.56
    HS-GAG degradation0.40
    HS-GAG biosynthesis0.56
    3Visual phototransduction
    Visual phototransduction0.48
    Diseases associated with visual transduction0.47
    Retinoid metabolism and transport0.48
    4A tetrasaccharide linker sequence is required for GAG synthesis
    Chondroitin sulfate/dermatan sulfate metabolism0.54
    A tetrasaccharide linker sequence is required for GAG synthesis0.54
    5Signaling by GPCR
    Signal Transduction0.55

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5/25        Reactome Pathways for GPC4 (see all 25)
        Diseases associated with visual transduction
    Chondroitin sulfate/dermatan sulfate metabolism
    MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    Visual phototransduction


    1         Kegg Pathway  (Kegg details for GPC4):
        Wnt signaling pathway


    GPC4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GPC4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/46 Interacting proteins for GPC4 (O754873 ENSP000003598644) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SQSTM1Q135013, ENSP000003744554I2D: score=3 STRING: ENSP00000374455
    ACP5P136863, ENSP000002187584I2D: score=1 STRING: ENSP00000218758
    FGF2P090383, ENSP000002644984I2D: score=2 STRING: ENSP00000264498
    ABHD17AQ96GS63I2D: score=1 
    CCNCP248633I2D: score=1 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001523retinoid metabolic process TAS--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006024glycosaminoglycan biosynthetic process TAS--
    GO:0006027glycosaminoglycan catabolic process TAS--
    GO:0007603phototransduction, visible light TAS--

    GPC4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GPC4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GPC4

    1 Novoseek inferred chemical compound relationship for GPC4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heparan sulfate 54.4 1 9931407 (1)

    Search CenterWatch for drugs/clinical trials and news about GPC4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GPC4 gene: 
    NM_001448.2  

    Unigene Cluster for GPC4:

    Glypican 4
    Hs.58367  [show with all ESTs]
    Unigene Representative Sequence: AF030186
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370828(uc011mvg.1 uc004exc.1) ENST00000535467
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidGPC4 3' UTR sequence
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    Additional mRNA sequence: 

    AF030186.1 AF064826.1 AF088063.1 AK304207.1 AK312605.1 AY052833.1 AY358507.1 BC017166.1 

    5 DOTS entries:

    DT.205743  DT.121323901  DT.121323884  DT.121323909  DT.435200 

    24/91 AceView cDNA sequences (see all 91):

    AA887423 AF088063 NM_001448 BE501034 AI908133 W74526 AW594222 AI492417 
    AY358507 AI908135 BC017166 AA729686 BM798989 AW237417 AU280056 BF814892 
    BF057716 BG314860 AA046130 BF445833 AU133310 W79865 W95636 AI651668 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GPC4 expression in normal human tissues (normalized intensities)      GPC4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTTAATAA
    GPC4 Expression
    About this image


    GPC4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/23 selected tissues (see all 23) fully expand
     
     Brain (Nervous System)    fully expand to see all 24 entries
             Thalamus
             N2/LSB/S/F8-induced cells ( Generation of midbrain dopaminergic, forebrain and hypothalamic...
             Human Astrocytes   
             Olfactory Bulb   
     
     Neural Tube (Nervous System)    fully expand to see all 8 entries
             Telencephalon
             spinal cord/lateral wall/ventricular layer   
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 7 entries
             ES03(HES-3)
             ESI-017   
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Bone marrow-derived mesenchymal stem cells
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
             skeleton/pectoral girdle and thoracic body wall/sternum   
     
     Spinal Cord (Nervous System)    fully expand to see all 3 entries
             Dorsal Horn   

    See GPC4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GPC4

    SOURCE GeneReport for Unigene cluster: Hs.58367
        SABiosciences Custom PCR Arrays for GPC4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPC4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for GPC4 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpc41 , 5 glypican 41, 5 90.83(n)1
    94.78(a)1
      X (28.33 cM)5
    147351  NM_008150.21  NP_032176.21 
     520530215 
    chicken
    (Gallus gallus)
    Aves GPC41 glypican 4 74.46(n)
    76.44(a)
      422234  XM_420222.3  XP_420222.2 
    lizard
    (Anolis carolinensis)
    Reptilia GPC46
    Uncharacterized protein
    71(a)
    1 ↔ 1
    GL344092.1(55759-69276)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.47202 Xenopus laevis Xgly4 mRNA for glypican-4, complete more 78.1(n)    AB082534.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gpc41 glypican 4 61.87(n)
    58.32(a)
      118437  NM_131860.2  NP_571935.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta dlp1 , 3 dally-like1 40(a)3
    49.93(n)1
    40.51(a)1
      395961  NM_079347.21  NP_524071.21 
    worm
    (Caenorhabditis elegans)
    Secernentea gpn-11 Protein GPN-1 41.71(n)
    26.96(a)
      181658  NM_078181.2  NP_510582.1 


    ENSEMBL Gene Tree for GPC4 (if available)
    TreeFam Gene Tree for GPC4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GPC4 gene
    GPC62  GPC32  GPC12  GPC22  GPC52  
    4 SIMAP similar genes for GPC4 using alignment to 3 protein entries:     GPC4_HUMAN (see all proteins):
    GPC6    GPC1    GPC2    GPC5

    GPC4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1438 SNPs in GPC4 are shown (see all 1438)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1428285711,2
    C--132391713(+) TTCATA/GGTTGA 1 -- ds50010--------
    rs22394631,2
    C,F,A,H--132392091(+) TCCCTC/TATATA 1 -- ds5001 ese317Minor allele frequency- T:0.48NS EA NA WA CSA 1983
    rs2000876831,2
    --132392103(+) AATGG-/AAGTGC 1 -- ds50010--------
    rs412990961,2
    C--132392136(+) ATTTGG/TTTTAA 1 -- ds50010--------
    rs1832328641,2
    --132392139(+) TGTTTA/TAAAAA 1 -- ds50010--------
    rs413002031,2
    C--132392142(+) TTTAAA/GAAAAA 1 -- ds50010--------
    rs59753901,2
    C,F,A,H--132392150(+) AAAAAC/ACACTT 1 -- ds50016Minor allele frequency- A:0.47NS EA NA WA 418
    rs2011758061,2
    --132392150(+) AAAAA-/CCACTT 1 -- ds50010--------
    rs777466851,2
    C--132392504(+) CCTTTG/TAAAGT 1 -- ut310--------
    rs1509007621,2
    --132392535(+) TTTTAC/TGAGCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for GPC4 (132434131 - 132549518 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for GPC4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv7100CNV Insertion18451855


    Human Gene Mutation Database (HGMD): GPC4

    Locus Specific Mutation Databases (LSDB): GPC4
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GPC4
    DNA2.0 Custom Variant and Variant Library Synthesis for GPC4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300168    OMIM disorders: --

    7 diseases for GPC4:    About MalaCards
    gpc4-related simpson-golabi-behmel syndrome type 1    simpson-golabi-behmel syndrome type 1    simpson-golabi-behmel syndrome    anoxia
    postaxial polydactyly type a    polydactyly    morquio syndrome b


    GPC4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GPC4

    Export disorders for GPC4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GPC4 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with GPC4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. GPC4, the gene for human K-glypican, flanks GPC3 on Xq26: deletion of the GPC3-GPC4 gene cluster in one family with Simpson-Golabi-Behmel syndrome. (PubMed id 9787072)1, 2, 3, 9 Veugelers M....David G. (1998)
    2. Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss- of-function mutations in the GPC3 gene. (PubMed id 10814714)1, 2, 9 Veugelers M.... David G. (2000)
    3. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    6. Glypican 3 and glypican 4 are juxtaposed in Xq26.1. (PubMed id 9931407)1, 9 Huber R....Crisponi L. (1998)
    7. Expression of glypican-4 in haematopoietic-progenitor and bone-marrow-stromal cells. (PubMed id 10585884)1, 9 Siebertz B....Haubeck H.D. (1999)
    8. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    9. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (2013)
    10. Bcl2-associated Athanogene 3 Interactome Analysis Reve als a New Role in Modulating Proteasome Activity. (PubMed id 23824909)1 Chen Y....Ge F. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2239 HGNC: 4452 AceView: GPC4 Ensembl:ENSG00000076716 euGenes: HUgn2239
    ECgene: GPC4 Kegg: 2239 H-InvDB: GPC4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GPC4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GPC4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GPC4 gene:
    Search GeneIP for patents involving GPC4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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