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GPC3 Gene

protein-coding GIFtS: 60

GC0XM132497

glypican 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: SDYS)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DGSX ^¹, ²
GTR2-2 ^³
MXR7 ^³
OCI-5 ^¹, ²
OCI5 ^³
OTTHUMP00000024058 ^²
OTTHUMP00000062492 ^²
SDYS ^², ⁵
SGB ^¹, ²
SGBS ^¹, ²
SGBS1 ^¹, ², ⁵

Descriptions
Intestinal protein OCI-5 ^³
glypican 3 ^²
glypican proteoglycan 3 ^²

External Ids
HGNC: 4451¹
Entrez Gene: 2719²
UniProtKB: P51654³
Ensembl: ENSG00000147257⁷

Search outside databases for aliases for GPC3 gene

Previous GC identifers: GC0XM127315 GC0XM129515 GC0XM130614 GC0XM131375 GC0XM132395

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for GPC3:

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core

substituted with a variable number of heparan sulfate chains. Members of the glypican-related

integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic

membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the

control of cell division and growth regulation. Deletion mutations in this gene are associated

with Simpson-Golabi-Behmel syndrome. [provided by RefSeq]

UniProtKB/Swiss-Prot: GPC3_HUMAN, P51654

Function: Cell surface proteoglycan that bears heparan sulfate. May be involved in the

suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a

role in the modulation of IGF2 interactions with its receptor and thereby modulate its function.

May regulate growth and tumor predisposition

Gene Wiki entry for GPC3 (Glypican_3)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GPC3 gene

Entrez Gene cytogenetic band: Xq26.1 Ensembl cytogenetic band: Xq26.2 HGNC cytogenetic band: Xq26

GPC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM132497: (about GC identifiers)

Start:	132,497,439 bp from pter
End:	132,947,332 bp from pter
Size:	449,894 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000023.9 NT_011786.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: GPC3_HUMAN, P51654 (See protein sequence)

Recommended Name: Glypican-3 precursor

Size: 580 amino acids; 65563 Da

Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side (By similarity)

Subcellular location: Secreted glypican-3: Secreted, extracellular space (By similarity)

REFSEQ proteins: NP_004475.1

ENSEMBL proteins:

ENSP00000377836 ENSP00000359854 ENSP00000385307

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for GPC3 (Glypican 3)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Glypican 3)
	Human Recombinant Proteins from Abnova (GPC3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/7 Gene Ontology (GO) cellular component terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005578	proteinaceous extracellular matrix	IEA	--
GO:0005737	cytoplasm	IDA	18029348
GO:0005794	Golgi apparatus	IDA	18029348
GO:0005886	plasma membrane	IEA	--

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Antibodies for GPC3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for GPC3
	R&D Systems Antibodies for GPC3 (Glypican 3)
	Antibodies from Abcam (Glypican 3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (GPC3)
	Novus Biologicals Antibody for GPC3

Assays for GPC3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P51654

ProtoNet protein and cluster: P51654

1 Blocks protein family: IPB001863 Glypican

UniProtKB/Swiss-Prot: GPC3_HUMAN, P51654

Similarity: Belongs to the glypican family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GPC3)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004484

Applied Biosystems Silencer® siRNAs for GPC3

Sigma-Aldrich siRNA and siRNA Panels for GPC3

Sigma-Aldrich shRNA Panels and shRNA for GPC3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for GPC3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004484
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004484
untagged cDNA clones in CMV expression vector (see all 2): NM_004484

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004484

UniProtKB/Swiss-Prot: GPC3_HUMAN, P51654

Function: Cell surface proteoglycan that bears heparan sulfate. May be involved in the

suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a

role in the modulation of IGF2 interactions with its receptor and thereby modulate its function.

May regulate growth and tumor predisposition

Genatlas biochemistry entry for GPC3:

glypican 3,60kDa,putative extracellular proteoglycan,involved in growth control in embryonic

mesodermal tissues,complexing with and putative modulator of IGF2,juxtaposed to GPC4,with tumor

suppression activity

15/17 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Gpc3) (see all 17 ):

cellular	craniofacial	digestive/alimentary	embryogenesis	growth/size
hematopoietic system	homeostasis/metabolism	immune system	lethality-postnatal	lethality-prenatal/perinatal
limbs/digits/tail	pigmentation	renal/urinary system	reproductive system	respiratory system

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for GPC3

5/17 Interacting proteins for GPC3 (ENSP00000359854³) via UniProtKB, MINT, and/or STRING (see all 17 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PTCH1	ENSP00000332353³	STRING (score=.934)
FURIN	ENSP00000268171³	STRING (score=.92)
SHH	ENSP00000297261³	STRING (score=.917)
FGF2	ENSP00000264498³	STRING (score=.908)
NUDT6	ENSP00000306070³	STRING (score=.908)

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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0009653	anatomical structure morphogenesis	TAS	8589713

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for GPC3
3 Novoseek chemical compound relationships for GPC3 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
heparan sulfate	50.64	3	18477453 (1), 10814714 (1), 15537637 (1)
oligonucleotide	0.00	1	12478660 (1)
lipid	0.00	1	15620688 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GPC3)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004484

Sigma-Aldrich siRNA and siRNA Panels for GPC3

Sigma-Aldrich shRNA Panels and shRNA for GPC3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004484

REFSEQ mRNAs for GPC3 gene:

NM_004484.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004484

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004484
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004484
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_004484

Additional cDNA sequence:

AK222761.1 AK222766.1 AK300168.1 AK310196.1 AK310689.1 BC035972.1 CR593041.1 CR594389.1

CR600770.1 CR611970.1 CR620091.1 CR624507.1 DQ349136.1 DQ349137.1 DQ349138.1 L47125.1

L47176.1 U50410.1 Z37987.1

15 DOTS entries:

DT.452188 DT.100884054 DT.100884058 DT.121306095 DT.95311297 DT.100026089 DT.91768760 DT.91768767

DT.95227507 DT.100697690 DT.100884069 DT.119635 DT.95311282 DT.100884067 DT.91768761

24/452 AceView cDNA sequences (see all 452 ):

NM_004484 BQ643589 AU131321 AI052443 AI076178 BM974181 AV686384 BI793159

AA971113 CR620091 BQ647204 L47176 BP374031 BX438697 BC035972 AA340731

Z37987 BU844616 AU117929 AU118103 CR600770 AA953049 CR611970 BI822082

highest scoring ESTs for GPC3:

U50410 AU117929 AU118103 AU118820 AU131321 AU135370 AU136239 AU137963 AU138269 AV750925

Unigene Cluster for GPC3:

Glypican 3

Hs.644108 [show with all ESTs]

Unigene Representative Sequence: NM_004484

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000394299 ENST00000370818 ENST00000406757

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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GPC3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GPC3

¹ / ² / ³

6 probe-sets matching GPC3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39350_at²^{, 3}	U95-A	1	1.00	1.00	0.97	1.01	U50410	1.00	0.90	0.95	1
79192_i_at*²^{, 3}	U95-D	1	--	--	0.64	1.01	R07953	0.20	1.00	0.72	1
209220_at²^{, 3}	U133-A	1	1.00	1.00	--	--	L47125	0.80	0.88	0.84	1
243243_at*²^{, 3}	U133-B	NULL	0.00	0.00	--	--	R07953	0.20	1.00	0.72	1
209220_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
243243_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--

GeneDecks GPC3 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GATTTCTTTG

SOURCE GeneReport for Unigene cluster: Hs.644108
Expression variation in blood from EXPOLDB for GPC3
UniProtKB/Swiss-Prot: GPC3_HUMAN, P51654
Tissue specificity: Highly expressed in lung, liver and kidney

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GPC3 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GPC3¹	--	glypican 3	92.18(n) 95.52(a)	481056 XM_538178.2 XP_538178.2
cow (Bos taurus)	GPC3¹	--	glypican 3	93.28(n) 95.69(a)	615239 NM_001035463.1 NP_001030540.1
rat (Rattus norvegicus)	Gpc3¹	--	glypican 3	90.78(n) 94.09(a)	25236 NM_012774.1 NP_036906.1
mouse (Mus musculus)	Gpc3^{1, 5}	X⁵	glypican 3^{1, 5}	90.73(n)¹ 94.13(a)¹	14734¹ NM_016697.2¹ NP_057906.2¹ AF185614⁵ AK077942⁵ (see all 17)
chicken (Gallus gallus)	GPC3¹	--	glypican 3	69.84(n) 68.66(a)	770863 XM_001232891.1 XP_001232892.1

About this table Species with no ortholog for GPC3

ENSEMBL Gene Tree for GPC3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for GPC3 gene

GPC5² GPC2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1006 NCBI SNPs in GPC3 are shown (see all 1006 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 234)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2267531^1,2	A,C,F	132947926(+)	`TCCCGC/GGAACC`	1	--	ng3¹		2	NA	182
--	rs12833276^1,2	H	132715336(+)	`AATCTC/TCACCA`	1	E/K	mis¹		4	EU EA WA	418
	rs12833292^1,2	H	132715339(+)	`CTCCAC/ACACAC`	1	L/V	mis¹		4	EU EA WA	418
	rs2314298^1,2	C,F,H	132558207(-)	`GGTGAT/CGATGA`	1	D/D	syn¹		5	EU EA WA NA	488
	rs1264383^1,2	A,C,F,H,O	132914376(+)	`CATGTG/ATCCCA`	1	--	int¹		7	EU EA WA NA	517
	rs1264379^1,2	A,C,F,H,O	132893432(+)	`GGACTA/GAGCCC`	1	--	int¹		11	EU EA WA NA	884
	rs2267519^1,2	A,C,F,H,O	132843934(+)	`TAACCA/GGTGCC`	1	--	int¹		16	EU EA WA NA	1023
	rs2267527^1,2	A,C,F,H,O	132930377(+)	`GTCACA/GCTAGT`	1	--	int¹		8	EU EA WA	733
	rs926228^1,2	A,C,F,H,O	132550050(+)	`ATAGGT/ACCTAA`	1	--	int¹		7	NA EA EU WA	668
	rs1264382^1,2	A,C,F,H,O	132907845(+)	`TTTTTA/TAATTA`	1	--	int¹		11	EU EA WA NA	881

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HapMap Linkage Disequilibrium images for GPC3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 300037 disorders: 312870 194070

UniProtKB/Swiss-Prot: GPC3_HUMAN, P51654

Defects in GPC3 are the cause of Simpson-Golabi-Behmel syndrome (SGBS) [MIM:312870]; also

known as Simpson dysmorphia syndrome (SDYS). SGBS is a condition characterized by pre- and

postnatal overgrowth (gigantism) with visceral and skeletal anomalies

10/39 Novoseek disease relationships for GPC3 gene (see all 39 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
perlman syndrome	89.13	2	11477610 (1), 10814714 (1)
embryonal tumor	78.39	4	11008203 (2), 7909248 (1), 16158429 (1)
beckwith-wiedemann syndrome	74.32	5	12949968 (1), 11477610 (1), 10814714 (1)
gigantism	69.23	3	7909248 (1), 9339360 (1), 10814714 (1)
hepatocellular carcinoma	68.41	47	15920546 (5), 15623647 (3), 16024626 (2), 16698587 (2) (see all 24)
sotos syndrome	66.70	1	11477610 (1)
nipples, supernumerary	64.27	1	11477610 (1)
wilms tumor	60.51	16	12949968 (5), 11878776 (3), 11008203 (2), 17350117 (1) (see all 6)
adenoma hepatocellular	60.41	5	18976006 (2), 16949914 (1), 15920546 (1), 9371521 (1)
mesothelioma	60.28	8	11320054 (1), 18404367 (1), 15537637 (1), 11704870 (1) (see all 5)

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GeneTests: GPC3

Simpson-Golabi-Behmel Syndrome

Human Gene Mutation Database: GPC3

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/129 PubMed articles for GPC3 gene (see all 129 ):

Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome. (PubMed id 8589713)^{1, 2, 3, 4} Pilia G.... Schlessinger D. (1996)
Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss- of-function mutations in the GPC3 gene. (PubMed id 10814714)^{1, 3, 4} Veugelers M.... David G. (2000)
GPC4, the gene for human K-glypican, flanks GPC3 on xq26: deletion of the GPC3-GPC4 gene cluster in one family with Simpson-Golabi-Behmel syndrome. (PubMed id 9787072)^{1, 2, 3} Veugelers M....David G. (1998)
Analysis of exon/intron structure and 400 kb of genomic sequence surrounding the 5'-promoter and 3'-terminal ends of the human glypican 3 (GPC3) gene. (PubMed id 9339360)^{1, 3, 4} Huber R.... Pilia G. (1997)
Cloning and characterization of human cDNAs encoding a protein with high homology to rat intestinal development protein OCI-5. (PubMed id 9133586)^{1, 3, 4} Lage H. and Dietel M. (1997)
Mapping of the Simpson-Golabi-Behmel overgrowth syndrome gene (GPC3) to chromosome X in human and rat by fluorescence in situ hybridization. (PubMed id 9021160)^{1, 3, 4} Shen T....Testa J.R. (1997)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{3, 4} Ross M.T.... Bentley D.R. (2005)
Oncofetal protein glypican-3 distinguishes yolk sac tumor from clear cell carcinoma of the ovary. (PubMed id 18277882)^{1, 3} Esheba G.E....Longacre T.A. (2008)
Expression pattern of glypican-3 (GPC3) during human embryonic and fetal development. (PubMed id 18785116)^{1, 3} Iglesias B.V....de Kier Joffe E.B. (2008)
The Simpson-Golabi-Behmel syndrome causative glypican-3, binds to and inhibits the dipeptidyl peptidase activity of CD26. (PubMed id 17549790)^{1, 3} Davoodi J....MacKenzie A.E. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2719	HGNC: 4451	AceView: GPC3	Ensembl:ENSG00000147257	euGenes: HUgn2719
ECgene: GPC3	H-InvDB: GPC3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for GPC3	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.genetests.org/query?gene=GPC3

Licensable Technologies for GPC3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for GPC3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GPC3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GPC3		Antibodies for GPC3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for GPC3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (GPC3)
	Antibodies (GPC3)
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	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Antibodies (Glypican 3)

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Search Tocris compounds for GPC3

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for GPC3

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GPC3 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for GPC3

Summaries
for GPC3

Genomic Location
for GPC3

Proteins
for GPC3

Protein Domains/
Families
for GPC3

Gene Function
for GPC3

Pathways & Interactions
for GPC3

Drugs & Compounds
for GPC3

Transcripts
for GPC3

Expression
for GPC3

Orthologs
for GPC3

Paralogs
for GPC3

SNPs/Variants
for GPC3

Disorders & Mutations
for GPC3

Medical News
for GPC3

Publications
for GPC3

Search for GPC3

Genome Databases showing GPC3

Other Databases showing GPC3

Specialized Databases showing GPC3

Licensable Technologies
for GPC3

Services
for GPC3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GPC3 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor GPC3

Summariesfor GPC3

Genomic Locationfor GPC3

Proteinsfor GPC3

Protein Domains/Familiesfor GPC3

Gene Functionfor GPC3

Pathways & Interactionsfor GPC3

Drugs & Compoundsfor GPC3

Transcriptsfor GPC3

Expression for GPC3

Orthologsfor GPC3

Paralogsfor GPC3

SNPs/Variantsfor GPC3

Disorders & Mutationsfor GPC3

Medical Newsfor GPC3

Publicationsfor GPC3

Search for GPC3

Genome Databases showing GPC3

Other Databases showing GPC3

Specialized Databases showing GPC3

Licensable Technologiesfor GPC3

Servicesfor GPC3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GPC3

Summaries
for GPC3

Genomic Location
for GPC3

Proteins
for GPC3

Protein Domains/
Families
for GPC3

Gene Function
for GPC3

Pathways & Interactions
for GPC3

Drugs & Compounds
for GPC3

Transcripts
for GPC3

Expression
for GPC3

Orthologs
for GPC3

Paralogs
for GPC3

SNPs/Variants
for GPC3

Disorders & Mutations
for GPC3

Medical News
for GPC3

Publications
for GPC3

Licensable Technologies
for GPC3

Services
for GPC3