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Aliases for GPC2 Gene

Aliases for GPC2 Gene

  • Glypican 2 2 3 5
  • Glypican Proteoglycan 2, Cerebroglycan Proteoglycan 2 3
  • Glypican 2 (Cerebroglycan) 2
  • Cerebroglycan Proteoglycan 3
  • Glypican-2 3

External Ids for GPC2 Gene

Previous GeneCards Identifiers for GPC2 Gene

  • GC00U990124
  • GC07M099364
  • GC07M099378
  • GC07M099411
  • GC07M099595
  • GC07M099768
  • GC07M094402
  • GC07M099777
  • GC07M099792

Summaries for GPC2 Gene

GeneCards Summary for GPC2 Gene

GPC2 (Glypican 2) is a Protein Coding gene. Among its related pathways are Chondroitin sulfate/dermatan sulfate metabolism and Metabolism of fat-soluble vitamins. GO annotations related to this gene include heparan sulfate proteoglycan binding. An important paralog of this gene is GPC6.

UniProtKB/Swiss-Prot for GPC2 Gene

  • Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons (By similarity).

Gene Wiki entry for GPC2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPC2 Gene

Genomics for GPC2 Gene

Regulatory Elements for GPC2 Gene

Enhancers for GPC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G100236 1 ENCODE 22.6 -60.4 -60412 2.4 ATF1 PKNOX1 ARNT TCF12 ZNF121 GLIS2 ZNF766 GATA2 KLF13 NCOA1 GPC2 PVRIG GATS STAG3 PILRA MOSPD3 LOC105375427 LOC105375426
GH07G100364 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.6 -193.5 -193543 12.5 HDGF PKNOX1 ATF1 AGO1 WRNIP1 SIN3A YBX1 ZBTB7B ZNF121 ZNF143 PILRA ZCWPW1 MEPCE MOSPD3 LAMTOR4 C7orf43 PVRIG ENSG00000241357 STAG3 GPC2
GH07G099373 1.8 FANTOM5 ENCODE dbSUPER 10.8 +799.1 799118 9.0 HDGF PKNOX1 CREB3L1 AGO1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 TRRAP TMEM225B ARPC1B ZNF394 BUD31 GPC2 LOC100131859 ZNF789 PILRA ATP5J2
GH07G100343 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.6 -167.6 -167606 3.0 HDGF PKNOX1 ATF1 CREB3L1 ARNT SIN3A FEZF1 GLI4 ZNF2 TCF12 PILRA MBLAC1 ZCWPW1 MEPCE LAMTOR4 ENSG00000241357 GPC2 GAL3ST4 C7orf43 PVRIG
GH07G100215 1.5 Ensembl ENCODE dbSUPER 12.5 -42.2 -42195 9.2 HDGF PKNOX1 WRNIP1 YY1 GLIS2 ZNF143 ZNF207 FOS JUNB REST PILRB STAG3L5P PVRIG MBLAC1 AP4M1 GPC2 CNPY4 GIGYF1 PILRA ZCWPW1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPC2 on UCSC Golden Path with GeneCards custom track

Promoters for GPC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000215753 126 1001 TBP HDAC1 PKNOX1 CBX3 SIN3A YY1 EGR1 PCBP1 FOS SP3

Genomic Location for GPC2 Gene

Chromosome:
7
Start:
100,169,606 bp from pter
End:
100,177,426 bp from pter
Size:
7,821 bases
Orientation:
Minus strand

Genomic View for GPC2 Gene

Genes around GPC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPC2 Gene

Proteins for GPC2 Gene

  • Protein details for GPC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N158-GPC2_HUMAN
    Recommended name:
    Glypican-2
    Protein Accession:
    Q8N158
    Secondary Accessions:
    • A4D2A7

    Protein attributes for GPC2 Gene

    Size:
    579 amino acids
    Molecular mass:
    62830 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPC2 Gene

Post-translational modifications for GPC2 Gene

  • Glycosylation at isoforms=55, isoforms=92, posLast=155155, isoforms=500, and isoforms=502
  • Modification sites at PhosphoSitePlus

Other Protein References for GPC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPC2 Gene

Domains & Families for GPC2 Gene

Gene Families for GPC2 Gene

Protein Domains for GPC2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GPC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N158

UniProtKB/Swiss-Prot:

GPC2_HUMAN :
  • Belongs to the glypican family.
Family:
  • Belongs to the glypican family.
genes like me logo Genes that share domains with GPC2: view

Function for GPC2 Gene

Molecular function for GPC2 Gene

UniProtKB/Swiss-Prot Function:
Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons (By similarity).

Gene Ontology (GO) - Molecular Function for GPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043395 heparan sulfate proteoglycan binding IEA --
genes like me logo Genes that share ontologies with GPC2: view
genes like me logo Genes that share phenotypes with GPC2: view

Animal Models for GPC2 Gene

MGI Knock Outs for GPC2:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPC2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GPC2 Gene

Localization for GPC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPC2 Gene

Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.
Secreted glypican-2: Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPC2 gene
Compartment Confidence
lysosome 5
plasma membrane 4
extracellular 4
endoplasmic reticulum 4
golgi apparatus 4
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for GPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IEA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005796 Golgi lumen TAS --
genes like me logo Genes that share ontologies with GPC2: view

Pathways & Interactions for GPC2 Gene

genes like me logo Genes that share pathways with GPC2: view

Gene Ontology (GO) - Biological Process for GPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0006024 glycosaminoglycan biosynthetic process TAS --
GO:0006027 glycosaminoglycan catabolic process TAS --
GO:0007224 smoothened signaling pathway IEA --
GO:0030182 neuron differentiation IEA --
genes like me logo Genes that share ontologies with GPC2: view

No data available for SIGNOR curated interactions for GPC2 Gene

Drugs & Compounds for GPC2 Gene

No Compound Related Data Available

Transcripts for GPC2 Gene

Unigene Clusters for GPC2 Gene

Glypican 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPC2 Gene

No ASD Table

Relevant External Links for GPC2 Gene

GeneLoc Exon Structure for
GPC2
ECgene alternative splicing isoforms for
GPC2

Expression for GPC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPC2 Gene

This gene is overexpressed in Testis (x8.9) and Skin - Not Sun Exposed (Suprapubic) (x4.8).

Protein differential expression in normal tissues from HIPED for GPC2 Gene

This gene is overexpressed in Fetal Brain (56.2) and Testis (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPC2 Gene



Protein tissue co-expression partners for GPC2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPC2 Gene:

GPC2

SOURCE GeneReport for Unigene cluster for GPC2 Gene:

Hs.211701

Evidence on tissue expression from TISSUES for GPC2 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with GPC2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPC2 Gene

Orthologs for GPC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPC2 34 35
  • 99.21 (n)
dog
(Canis familiaris)
Mammalia GPC2 34 35
  • 82.98 (n)
cow
(Bos Taurus)
Mammalia GPC2 34 35
  • 82.87 (n)
mouse
(Mus musculus)
Mammalia Gpc2 34 16 35
  • 81.56 (n)
rat
(Rattus norvegicus)
Mammalia Gpc2 34
  • 81.47 (n)
oppossum
(Monodelphis domestica)
Mammalia GPC2 35
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPC2 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 20 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 24 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii gpc2 35
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta dlp 35
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gpn-1 35
  • 21 (a)
OneToMany
Species where no ortholog for GPC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GPC2 Gene

ENSEMBL:
Gene Tree for GPC2 (if available)
TreeFam:
Gene Tree for GPC2 (if available)

Paralogs for GPC2 Gene

Paralogs for GPC2 Gene

(3) SIMAP similar genes for GPC2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPC2: view

Variants for GPC2 Gene

Sequence variations from dbSNP and Humsavar for GPC2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_036045 A breast cancer sample
rs1000133510 -- 100,178,744(+) GAGCA(A/G)TTCCA intron-variant, upstream-variant-2KB
rs1000195303 -- 100,176,809(+) AATTA(A/G/T)GAGGA intron-variant, upstream-variant-2KB
rs1000444312 -- 100,170,683(+) CAGAC(A/G)TGGGG intron-variant, upstream-variant-2KB
rs1000485949 -- 100,179,075(+) GGTTA(A/G)GCAGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GPC2 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV deletion 23290073
nsv428180 CNV gain 18775914
nsv5867 CNV deletion 18451855
nsv607931 CNV loss 21841781

Variation tolerance for GPC2 Gene

Residual Variation Intolerance Score: 35.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 21.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPC2 Gene

Disorders for GPC2 Gene

Relevant External Links for GPC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPC2

No disorders were found for GPC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPC2 Gene

Publications for GPC2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  4. Cerebroglycan: an integral membrane heparan sulfate proteoglycan that is unique to the developing nervous system and expressed specifically during neuronal differentiation. (PMID: 8294498) Stipp C.S. … Lander A.D. (J. Cell Biol. 1994) 2 3 64
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64

Products for GPC2 Gene

Sources for GPC2 Gene

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