External Ids for GPC1 Gene
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq, Jul 2008]
GeneCards Summary for GPC1 Gene
GPC1 (Glypican 1) is a Protein Coding gene. Diseases associated with GPC1 include biliary atresia. Among its related pathways are Signaling by GPCR and Proteoglycans in cancer. GO annotations related to this gene include copper ion binding and laminin binding. An important paralog of this gene is GPC4.
UniProtKB/Swiss-Prot for GPC1 Gene
Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling.