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Aliases for GPBP1L1 Gene

Aliases for GPBP1L1 Gene

  • GC-Rich Promoter Binding Protein 1 Like 1 2 3 5
  • GC-Rich Promoter Binding Protein 1-Like 1 2
  • GC-Rich Promoter-Binding Protein 1-Like 1 4
  • Vasculin-Like Protein 1 3
  • SP192 3

External Ids for GPBP1L1 Gene

Previous GeneCards Identifiers for GPBP1L1 Gene

  • GC01M045763
  • GC01M045865
  • GC01M046092
  • GC01M044204

Summaries for GPBP1L1 Gene

GeneCards Summary for GPBP1L1 Gene

GPBP1L1 (GC-Rich Promoter Binding Protein 1 Like 1) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is GPBP1.

UniProtKB/Swiss-Prot for GPBP1L1 Gene

  • Possible transcription factor.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPBP1L1 Gene

Genomics for GPBP1L1 Gene

Regulatory Elements for GPBP1L1 Gene

Enhancers for GPBP1L1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G046130 1.2 ENCODE 45.3 -445.2 -445189 5.6 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 TOE1 GPBP1L1 RPL7AP16 CCDC163 MAST2 EFCAB14-AS1 RPS15AP10 TMEM69 ZSWIM5 TSPAN1
GH01G044720 1.7 Ensembl ENCODE dbSUPER 30.3 +965.3 965310 4.8 MLX CREB3L1 AGO1 ZFP64 FEZF1 YBX1 YY1 ZNF143 SP3 NFYC GPBP1L1 TOE1 RPS8 RPL7AP16 RPS15AP10 DMAP1 TMEM69 SNORD38B RPS15AP11 UROD
GH01G046246 1.4 FANTOM5 ENCODE 27.1 -559.9 -559897 3.1 HDGF PKNOX1 MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 TOE1 GPBP1L1 EFCAB14-AS1 RPL7AP16 IPP RPS15AP10 TMEM69 NSUN4 RAD54L GC01M046227
GH01G044729 1.4 ENCODE dbSUPER 27 +956.7 956740 2.8 CREB3L1 FEZF1 YBX1 YY1 ZNF143 SP3 NFYC TBX21 MEF2D ZNF610 RPS8 TOE1 GPBP1L1 RPL7AP16 RPS15AP10 TMEM69 UROD BEST4 KIF2C BTBD19
GH01G045302 1.2 ENCODE 31.2 +383.9 383926 2.7 CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 MEF2D ZNF610 TOE1 RPL7AP16 RPS15AP10 GPBP1L1 TMEM69 RPS8 ZSWIM5 CCDC163 PTCH2 POMGNT1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPBP1L1 on UCSC Golden Path with GeneCards custom track

Promoters for GPBP1L1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000005881 1313 4801 CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3

Genomic Location for GPBP1L1 Gene

Chromosome:
1
Start:
45,627,304 bp from pter
End:
45,688,113 bp from pter
Size:
60,810 bases
Orientation:
Minus strand

Genomic View for GPBP1L1 Gene

Genes around GPBP1L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPBP1L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPBP1L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPBP1L1 Gene

Proteins for GPBP1L1 Gene

  • Protein details for GPBP1L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HC44-GPBL1_HUMAN
    Recommended name:
    Vasculin-like protein 1
    Protein Accession:
    Q9HC44
    Secondary Accessions:
    • D3DQ10
    • Q9H751

    Protein attributes for GPBP1L1 Gene

    Size:
    474 amino acids
    Molecular mass:
    52302 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPBP1L1 Gene

Post-translational modifications for GPBP1L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPBP1L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPBP1L1 Gene

Domains & Families for GPBP1L1 Gene

Protein Domains for GPBP1L1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPBP1L1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HC44

UniProtKB/Swiss-Prot:

GPBL1_HUMAN :
  • Belongs to the vasculin family.
Family:
  • Belongs to the vasculin family.
genes like me logo Genes that share domains with GPBP1L1: view

No data available for Gene Families for GPBP1L1 Gene

Function for GPBP1L1 Gene

Molecular function for GPBP1L1 Gene

UniProtKB/Swiss-Prot Function:
Possible transcription factor.

Gene Ontology (GO) - Molecular Function for GPBP1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
genes like me logo Genes that share ontologies with GPBP1L1: view
genes like me logo Genes that share phenotypes with GPBP1L1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPBP1L1 Gene

Localization for GPBP1L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPBP1L1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPBP1L1 gene
Compartment Confidence
nucleus 5
plasma membrane 2
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for GPBP1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with GPBP1L1: view

Pathways & Interactions for GPBP1L1 Gene

SuperPathways for GPBP1L1 Gene

No Data Available

Interacting Proteins for GPBP1L1 Gene

Gene Ontology (GO) - Biological Process for GPBP1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
GO:0045893 positive regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with GPBP1L1: view

No data available for Pathways by source and SIGNOR curated interactions for GPBP1L1 Gene

Drugs & Compounds for GPBP1L1 Gene

No Compound Related Data Available

Transcripts for GPBP1L1 Gene

Unigene Clusters for GPBP1L1 Gene

GC-rich promoter binding protein 1-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPBP1L1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16
SP1: - - -
SP2: -
SP3: - - -
SP4: - -
SP5:
SP6: -
SP7:
SP8:

Relevant External Links for GPBP1L1 Gene

GeneLoc Exon Structure for
GPBP1L1
ECgene alternative splicing isoforms for
GPBP1L1

Expression for GPBP1L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPBP1L1 Gene

Protein differential expression in normal tissues from HIPED for GPBP1L1 Gene

This gene is overexpressed in CD8 Tcells (28.1), Testis (22.7), and Platelet (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GPBP1L1 Gene



Protein tissue co-expression partners for GPBP1L1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPBP1L1 Gene:

GPBP1L1

SOURCE GeneReport for Unigene cluster for GPBP1L1 Gene:

Hs.238432

Evidence on tissue expression from TISSUES for GPBP1L1 Gene

  • Intestine(4.3)
  • Liver(4.3)
  • Pancreas(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with GPBP1L1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPBP1L1 Gene

Orthologs for GPBP1L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPBP1L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPBP1L1 34 35
  • 99.51 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 94 (a)
OneToMany
GPBP1L1 34
  • 91.84 (n)
-- 35
  • 85 (a)
OneToMany
dog
(Canis familiaris)
Mammalia GPBP1L1 34 35
  • 92.74 (n)
mouse
(Mus musculus)
Mammalia Gpbp1l1 34 16 35
  • 88.23 (n)
rat
(Rattus norvegicus)
Mammalia Gpbp1l1 34
  • 86.89 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GPBP1L1 35
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPBP1L1 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPBP1L1 34 35
  • 79.72 (n)
lizard
(Anolis carolinensis)
Reptilia GPBP1L1 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpbp1l1 34
  • 66.81 (n)
Str.5410 34
zebrafish
(Danio rerio)
Actinopterygii gpbp1l1 34 35
  • 64.49 (n)
wufc48e01 34
Species where no ortholog for GPBP1L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPBP1L1 Gene

ENSEMBL:
Gene Tree for GPBP1L1 (if available)
TreeFam:
Gene Tree for GPBP1L1 (if available)

Paralogs for GPBP1L1 Gene

Paralogs for GPBP1L1 Gene

(1) SIMAP similar genes for GPBP1L1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GPBP1L1: view

Variants for GPBP1L1 Gene

Sequence variations from dbSNP and Humsavar for GPBP1L1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000115167 -- 45,649,748(+) AAATG(C/T)TAATA intron-variant
rs1000154561 -- 45,687,547(+) GCCTG(G/T)TGCCA upstream-variant-2KB
rs1000197700 -- 45,673,624(+) TGGGA(A/G)GCCAA intron-variant
rs1000288893 -- 45,646,015(+) GTTCA(C/T)AATTT intron-variant, nc-transcript-variant
rs1000301260 -- 45,684,715(+) TAGTA(C/G)TTAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPBP1L1 Gene

Variant ID Type Subtype PubMed ID
esv3577360 CNV gain 25503493
esv3585911 CNV gain 21293372
esv3585913 CNV loss 21293372
esv3893512 CNV gain 25118596
nsv1014128 CNV gain 25217958
nsv473336 CNV novel sequence insertion 20440878
nsv479972 CNV novel sequence insertion 20440878
nsv829726 CNV loss 17160897
nsv945921 CNV duplication 23825009

Variation tolerance for GPBP1L1 Gene

Residual Variation Intolerance Score: 44.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.98; 49.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPBP1L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPBP1L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPBP1L1 Gene

Disorders for GPBP1L1 Gene

Relevant External Links for GPBP1L1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPBP1L1

No disorders were found for GPBP1L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPBP1L1 Gene

Publications for GPBP1L1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  3. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3 64
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3 64

Products for GPBP1L1 Gene

Sources for GPBP1L1 Gene

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