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Aliases for GPBP1L1 Gene

Aliases for GPBP1L1 Gene

  • GC-Rich Promoter Binding Protein 1-Like 1 2 3
  • GC-Rich Promoter-Binding Protein 1-Like 1 3 4
  • SP192 3

External Ids for GPBP1L1 Gene

Previous GeneCards Identifiers for GPBP1L1 Gene

  • GC01M045763
  • GC01M045865
  • GC01M046092
  • GC01M044204

Summaries for GPBP1L1 Gene

GeneCards Summary for GPBP1L1 Gene

GPBP1L1 (GC-Rich Promoter Binding Protein 1-Like 1) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is GPBP1.

UniProtKB/Swiss-Prot for GPBP1L1 Gene

  • Possible transcription factor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPBP1L1 Gene

Genomics for GPBP1L1 Gene

Regulatory Elements for GPBP1L1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GPBP1L1 Gene

Chromosome:
1
Start:
45,627,304 bp from pter
End:
45,688,113 bp from pter
Size:
60,810 bases
Orientation:
Minus strand

Genomic View for GPBP1L1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPBP1L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPBP1L1 Gene

Proteins for GPBP1L1 Gene

  • Protein details for GPBP1L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HC44-GPBL1_HUMAN
    Recommended name:
    Vasculin-like protein 1
    Protein Accession:
    Q9HC44
    Secondary Accessions:
    • D3DQ10
    • Q9H751

    Protein attributes for GPBP1L1 Gene

    Size:
    474 amino acids
    Molecular mass:
    52302 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPBP1L1 Gene

Proteomics data for GPBP1L1 Gene at MOPED

Post-translational modifications for GPBP1L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPBP1L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPBP1L1 Gene

Domains & Families for GPBP1L1 Gene

Protein Domains for GPBP1L1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPBP1L1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HC44

UniProtKB/Swiss-Prot:

GPBL1_HUMAN :
  • Belongs to the vasculin family.
Family:
  • Belongs to the vasculin family.
genes like me logo Genes that share domains with GPBP1L1: view

No data available for Gene Families for GPBP1L1 Gene

Function for GPBP1L1 Gene

Molecular function for GPBP1L1 Gene

UniProtKB/Swiss-Prot Function:
Possible transcription factor.

Gene Ontology (GO) - Molecular Function for GPBP1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
genes like me logo Genes that share ontologies with GPBP1L1: view

Phenotypes for GPBP1L1 Gene

genes like me logo Genes that share phenotypes with GPBP1L1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPBP1L1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GPBP1L1 Gene

Localization for GPBP1L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPBP1L1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPBP1L1 Gene COMPARTMENTS Subcellular localization image for GPBP1L1 gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for GPBP1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with GPBP1L1: view

Pathways & Interactions for GPBP1L1 Gene

SuperPathways for GPBP1L1 Gene

No Data Available

Interacting Proteins for GPBP1L1 Gene

Gene Ontology (GO) - Biological Process for GPBP1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0045893 positive regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with GPBP1L1: view

No data available for Pathways by source and SIGNOR curated interactions for GPBP1L1 Gene

Drugs & Compounds for GPBP1L1 Gene

No Compound Related Data Available

Transcripts for GPBP1L1 Gene

Unigene Clusters for GPBP1L1 Gene

GC-rich promoter binding protein 1-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPBP1L1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPBP1L1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16
SP1: - - -
SP2: -
SP3: - - -
SP4: - -
SP5:
SP6: -
SP7:
SP8:

Relevant External Links for GPBP1L1 Gene

GeneLoc Exon Structure for
GPBP1L1
ECgene alternative splicing isoforms for
GPBP1L1

Expression for GPBP1L1 Gene

mRNA expression in normal human tissues for GPBP1L1 Gene

Protein differential expression in normal tissues from HIPED for GPBP1L1 Gene

This gene is overexpressed in CD8 Tcells (28.1), Testis (22.7), and Platelet (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GPBP1L1 Gene



SOURCE GeneReport for Unigene cluster for GPBP1L1 Gene Hs.238432

genes like me logo Genes that share expression patterns with GPBP1L1: view

Protein tissue co-expression partners for GPBP1L1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GPBP1L1 Gene

Orthologs for GPBP1L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPBP1L1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPBP1L1 35
  • 91.84 (n)
  • 93.88 (a)
-- 36
  • 85 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
dog
(Canis familiaris)
Mammalia GPBP1L1 35
  • 92.74 (n)
  • 95.35 (a)
GPBP1L1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpbp1l1 35
  • 88.23 (n)
  • 89.79 (a)
Gpbp1l1 16
Gpbp1l1 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPBP1L1 35
  • 99.51 (n)
  • 99.79 (a)
GPBP1L1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpbp1l1 35
  • 86.89 (n)
  • 89.64 (a)
oppossum
(Monodelphis domestica)
Mammalia GPBP1L1 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPBP1L1 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPBP1L1 35
  • 79.72 (n)
  • 82.13 (a)
GPBP1L1 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPBP1L1 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpbp1l1 35
  • 66.81 (n)
  • 65.3 (a)
Str.5410 35
zebrafish
(Danio rerio)
Actinopterygii gpbp1l1 35
  • 64.49 (n)
  • 63.4 (a)
wufc48e01 35
gpbp1l1 36
  • 58 (a)
OneToOne
Species with no ortholog for GPBP1L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPBP1L1 Gene

ENSEMBL:
Gene Tree for GPBP1L1 (if available)
TreeFam:
Gene Tree for GPBP1L1 (if available)

Paralogs for GPBP1L1 Gene

Paralogs for GPBP1L1 Gene

(1) SIMAP similar genes for GPBP1L1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GPBP1L1: view

Variants for GPBP1L1 Gene

Sequence variations from dbSNP and Humsavar for GPBP1L1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1250 -- 45,628,355(+) AACAG(A/G)CTGGA synonymous-codon, reference
rs4180 -- 45,627,735(+) AAAAA(A/C)AAAAA utr-variant-3-prime
rs1135812 -- 45,629,600(-) CTCAA(A/G/T)GAGTT reference, synonymous-codon
rs1135850 -- 45,628,020(-) ACTCA(C/G/T)ACACA utr-variant-3-prime
rs1135887 -- 45,627,568(-) TAAAA(A/G)ATGTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GPBP1L1 Gene

Variant ID Type Subtype PubMed ID
nsv829726 CNV Loss 17160897
nsv871928 CNV Gain 21882294
nsv870511 CNV Gain 21882294

Variation tolerance for GPBP1L1 Gene

Residual Variation Intolerance Score: 44.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.98; 49.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPBP1L1 Gene

HapMap Linkage Disequilibrium report
GPBP1L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPBP1L1 Gene

Disorders for GPBP1L1 Gene

Relevant External Links for GPBP1L1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPBP1L1
genes like me logo Genes that share disorders with GPBP1L1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPBP1L1 Gene

Publications for GPBP1L1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 67
  3. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 67
  4. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PMID: 19690332) Mayya V. … Han D.K. (Sci. Signal. 2009) 67
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 67

Products for GPBP1L1 Gene

Sources for GPBP1L1 Gene

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