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Aliases for GPBP1L1 Gene

Aliases for GPBP1L1 Gene

  • GC-Rich Promoter Binding Protein 1 Like 1 2 3 5
  • GC-Rich Promoter Binding Protein 1-Like 1 2
  • GC-Rich Promoter-Binding Protein 1-Like 1 4
  • Vasculin-Like Protein 1 3
  • SP192 3

External Ids for GPBP1L1 Gene

Previous GeneCards Identifiers for GPBP1L1 Gene

  • GC01M045763
  • GC01M045865
  • GC01M046092
  • GC01M044204

Summaries for GPBP1L1 Gene

GeneCards Summary for GPBP1L1 Gene

GPBP1L1 (GC-Rich Promoter Binding Protein 1 Like 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity. An important paralog of this gene is GPBP1.

UniProtKB/Swiss-Prot for GPBP1L1 Gene

  • Possible transcription factor.

Additional gene information for GPBP1L1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPBP1L1 Gene

Genomics for GPBP1L1 Gene

GeneHancer (GH) Regulatory Elements for GPBP1L1 Gene

Promoters and enhancers for GPBP1L1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I045684 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 617.2 +1.1 1143 5.1 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 GPBP1L1 TMEM69 LRRC41 TOE1 RPS8 RPL7AP16 EFCAB14-AS1 HECTD3 MAST2 RPS15AP10
GH01I044774 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 96.8 +911.9 911895 3.7 ZFP64 DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF143 MCM3 SP3 RPS8 GC01P044811 GC01P044822 GC01P044828 GC01P044830 SNORD38A SNORD55 SNORD46 GC01P044833 GC01P044831
GH01I044729 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 106.8 +956.7 956739 2.8 CLOCK FEZF1 YBX1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC MEF2D GC01M044732 RNU5D-1 GPBP1L1 TOE1 RPL7AP16 RPS8 HECTD3 RPS15AP10 NASP TMEM69
GH01I045582 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 83 +103.3 103264 5.4 HDGF HNRNPUL1 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 NASP GC01M045583 GPBP1L1 TOE1 LRRC41 RPL7AP16 MUTYH CCDC163 HECTD3 RPS8
GH01I046129 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 76.9 -444.8 -444840 6.3 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 PIK3R3 LOC101929626 TOE1 GPBP1L1 LRRC41 RPL7AP16 EFCAB14-AS1 RPS15AP10 MOB3C TMEM69
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GPBP1L1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPBP1L1 gene promoter:

Genomic Locations for GPBP1L1 Gene

Genomic Locations for GPBP1L1 Gene
chr1:45,627,304-45,688,113
(GRCh38/hg38)
Size:
60,810 bases
Orientation:
Minus strand
chr1:46,092,976-46,153,785
(GRCh37/hg19)

Genomic View for GPBP1L1 Gene

Genes around GPBP1L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPBP1L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPBP1L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPBP1L1 Gene

Proteins for GPBP1L1 Gene

  • Protein details for GPBP1L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HC44-GPBL1_HUMAN
    Recommended name:
    Vasculin-like protein 1
    Protein Accession:
    Q9HC44
    Secondary Accessions:
    • D3DQ10
    • Q9H751

    Protein attributes for GPBP1L1 Gene

    Size:
    474 amino acids
    Molecular mass:
    52302 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPBP1L1 Gene

Post-translational modifications for GPBP1L1 Gene

No Post-translational modifications

Other Protein References for GPBP1L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPBP1L1 Gene

Domains & Families for GPBP1L1 Gene

Gene Families for GPBP1L1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GPBP1L1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPBP1L1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HC44

UniProtKB/Swiss-Prot:

GPBL1_HUMAN :
  • Belongs to the vasculin family.
Family:
  • Belongs to the vasculin family.
genes like me logo Genes that share domains with GPBP1L1: view

Function for GPBP1L1 Gene

Molecular function for GPBP1L1 Gene

UniProtKB/Swiss-Prot Function:
Possible transcription factor.

Phenotypes From GWAS Catalog for GPBP1L1 Gene

Gene Ontology (GO) - Molecular Function for GPBP1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
genes like me logo Genes that share ontologies with GPBP1L1: view
genes like me logo Genes that share phenotypes with GPBP1L1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPBP1L1 Gene

Localization for GPBP1L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPBP1L1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPBP1L1 gene
Compartment Confidence
nucleus 5
plasma membrane 2
cytosol 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Focal adhesion sites (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPBP1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with GPBP1L1: view

Pathways & Interactions for GPBP1L1 Gene

SuperPathways for GPBP1L1 Gene

No Data Available

Interacting Proteins for GPBP1L1 Gene

Gene Ontology (GO) - Biological Process for GPBP1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0045893 positive regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with GPBP1L1: view

No data available for Pathways by source and SIGNOR curated interactions for GPBP1L1 Gene

Drugs & Compounds for GPBP1L1 Gene

No Compound Related Data Available

Transcripts for GPBP1L1 Gene

Unigene Clusters for GPBP1L1 Gene

GC-rich promoter binding protein 1-like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPBP1L1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16
SP1: - - -
SP2: -
SP3: - - -
SP4: - -
SP5:
SP6: -
SP7:
SP8:

Relevant External Links for GPBP1L1 Gene

GeneLoc Exon Structure for
GPBP1L1
ECgene alternative splicing isoforms for
GPBP1L1

Expression for GPBP1L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPBP1L1 Gene

Protein differential expression in normal tissues from HIPED for GPBP1L1 Gene

This gene is overexpressed in CD8 Tcells (28.1), Testis (22.7), and Platelet (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GPBP1L1 Gene



Protein tissue co-expression partners for GPBP1L1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPBP1L1 Gene:

GPBP1L1

SOURCE GeneReport for Unigene cluster for GPBP1L1 Gene:

Hs.238432

Evidence on tissue expression from TISSUES for GPBP1L1 Gene

  • Intestine(4.3)
  • Liver(4.3)
  • Pancreas(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with GPBP1L1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPBP1L1 Gene

Orthologs for GPBP1L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPBP1L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPBP1L1 33 34
  • 99.51 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 94 (a)
OneToMany
GPBP1L1 33
  • 91.84 (n)
-- 34
  • 85 (a)
OneToMany
dog
(Canis familiaris)
Mammalia GPBP1L1 33 34
  • 92.74 (n)
mouse
(Mus musculus)
Mammalia Gpbp1l1 33 16 34
  • 88.23 (n)
rat
(Rattus norvegicus)
Mammalia Gpbp1l1 33
  • 86.89 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GPBP1L1 34
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPBP1L1 34
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPBP1L1 33 34
  • 79.72 (n)
lizard
(Anolis carolinensis)
Reptilia GPBP1L1 34
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpbp1l1 33
  • 66.81 (n)
Str.5410 33
zebrafish
(Danio rerio)
Actinopterygii gpbp1l1 33 34
  • 64.49 (n)
wufc48e01 33
Species where no ortholog for GPBP1L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPBP1L1 Gene

ENSEMBL:
Gene Tree for GPBP1L1 (if available)
TreeFam:
Gene Tree for GPBP1L1 (if available)

Paralogs for GPBP1L1 Gene

Paralogs for GPBP1L1 Gene

(1) SIMAP similar genes for GPBP1L1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GPBP1L1: view

Variants for GPBP1L1 Gene

Sequence variations from dbSNP and Humsavar for GPBP1L1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000115167 -- 45,649,748(-) C/T intron_variant
rs1000154561 -- 45,687,547(-) G/T upstream_transcript_variant
rs1000197700 -- 45,673,624(-) G/A intron_variant
rs1000288893 -- 45,646,015(-) C/T intron_variant
rs1000301260 -- 45,684,715(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GPBP1L1 Gene

Variant ID Type Subtype PubMed ID
esv3577360 CNV gain 25503493
esv3585911 CNV gain 21293372
esv3585913 CNV loss 21293372
esv3893512 CNV gain 25118596
nsv1014128 CNV gain 25217958
nsv473336 CNV novel sequence insertion 20440878
nsv479972 CNV novel sequence insertion 20440878
nsv829726 CNV loss 17160897
nsv945921 CNV duplication 23825009

Variation tolerance for GPBP1L1 Gene

Residual Variation Intolerance Score: 44.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.98; 49.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPBP1L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPBP1L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPBP1L1 Gene

Disorders for GPBP1L1 Gene

Additional Disease Information for GPBP1L1

No disorders were found for GPBP1L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPBP1L1 Gene

Publications for GPBP1L1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 58
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
  5. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) Kırlı K … Görlich D (eLife 2015) 3 58

Products for GPBP1L1 Gene

Sources for GPBP1L1 Gene

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