Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GPBAR1 Gene

Aliases for GPBAR1 Gene

  • G Protein-Coupled Bile Acid Receptor 1 2 3
  • Membrane-Type Receptor For Bile Acids 3 4
  • G-Protein Coupled Receptor GPCR19 3 4
  • HGPCR19 3 4
  • M-BAR 3 4
  • HBG37 3 4
  • BG37 3 4
  • TGR5 3 4
  • G-Protein Coupled Bile Acid Receptor BG37 3
  • Membrane Bile Acid Receptor 3
  • GPCR19 3
  • GPR131 3

External Ids for GPBAR1 Gene

Previous GeneCards Identifiers for GPBAR1 Gene

  • GC02P217847
  • GC02P219090
  • GC02P219328
  • GC02P218949
  • GC02P218832
  • GC02P219124
  • GC02P210978

Summaries for GPBAR1 Gene

Entrez Gene Summary for GPBAR1 Gene

  • This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPBAR1 Gene

GPBAR1 (G Protein-Coupled Bile Acid Receptor 1) is a Protein Coding gene. Diseases associated with GPBAR1 include functional diarrhea and sclerosing cholangitis. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled bile acid receptor activity.

UniProtKB/Swiss-Prot for GPBAR1 Gene

  • Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids.

Gene Wiki entry for GPBAR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPBAR1 Gene

Genomics for GPBAR1 Gene

Regulatory Elements for GPBAR1 Gene

Genomic Location for GPBAR1 Gene

Chromosome:
2
Start:
218,259,496 bp from pter
End:
218,263,861 bp from pter
Size:
4,366 bases
Orientation:
Plus strand

Genomic View for GPBAR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPBAR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPBAR1 Gene

Proteins for GPBAR1 Gene

  • Protein details for GPBAR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDU6-GPBAR_HUMAN
    Recommended name:
    G-protein coupled bile acid receptor 1
    Protein Accession:
    Q8TDU6
    Secondary Accessions:
    • B3KV35

    Protein attributes for GPBAR1 Gene

    Size:
    330 amino acids
    Molecular mass:
    35248 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPBAR1 Gene

Proteomics data for GPBAR1 Gene at MOPED

Post-translational modifications for GPBAR1 Gene

  • Glycosylation at Asn 4 and Asn 76

Other Protein References for GPBAR1 Gene

Antibody Products

No data available for DME Specific Peptides for GPBAR1 Gene

Domains & Families for GPBAR1 Gene

Gene Families for GPBAR1 Gene

Protein Domains for GPBAR1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPBAR1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TDU6

UniProtKB/Swiss-Prot:

GPBAR_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPBAR1: view

Function for GPBAR1 Gene

Molecular function for GPBAR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids.

Gene Ontology (GO) - Molecular Function for GPBAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
GO:0038181 bile acid receptor activity IDA 12419312
GO:0038182 G-protein coupled bile acid receptor activity NAS 12419312
genes like me logo Genes that share ontologies with GPBAR1: view
genes like me logo Genes that share phenotypes with GPBAR1: view

Animal Models for GPBAR1 Gene

MGI Knock Outs for GPBAR1:

Animal Model Products

CRISPR Products

miRNA for GPBAR1 Gene

miRTarBase miRNAs that target GPBAR1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPBAR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for GPBAR1 Gene

Localization for GPBAR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPBAR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPBAR1 Gene COMPARTMENTS Subcellular localization image for GPBAR1 gene
Compartment Confidence
plasma membrane 5
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for GPBAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12524422
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with GPBAR1: view

Pathways & Interactions for GPBAR1 Gene

genes like me logo Genes that share pathways with GPBAR1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for GPBAR1 Gene

Gene Ontology (GO) - Biological Process for GPBAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0038184 cell surface bile acid receptor signaling pathway IC 12524422
GO:2000810 regulation of bicellular tight junction assembly IEA --
genes like me logo Genes that share ontologies with GPBAR1: view

No data available for SIGNOR curated interactions for GPBAR1 Gene

Drugs & Compounds for GPBAR1 Gene

(16) Drugs for GPBAR1 Gene - From: NovoSeek, HMDB, IUPHAR, ApexBio, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
deoxycholic acid Approved Pharma Antagonist 40
chenodeoxycholic acid Approved Pharma Antagonist 23
cholic acid Approved Pharma Full agonist, Agonist 0
Dopamine Approved Pharma Full agonist, Agonist 2814
cyclic amp Experimental Pharma 0

(6) Additional Compounds for GPBAR1 Gene - From: NovoSeek

genes like me logo Genes that share compounds with GPBAR1: view

Transcripts for GPBAR1 Gene

Unigene Clusters for GPBAR1 Gene

G protein-coupled bile acid receptor 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPBAR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPBAR1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c
SP1: - - - - -
SP2:
SP3: - -
SP4: -

Relevant External Links for GPBAR1 Gene

GeneLoc Exon Structure for
GPBAR1
ECgene alternative splicing isoforms for
GPBAR1

Expression for GPBAR1 Gene

mRNA expression in normal human tissues for GPBAR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPBAR1 Gene

This gene is overexpressed in Whole Blood (x10.9), Adipose - Visceral (Omentum) (x7.4), and Adipose - Subcutaneous (x7.0).

SOURCE GeneReport for Unigene cluster for GPBAR1 Gene Hs.160954

mRNA Expression by UniProt/SwissProt for GPBAR1 Gene

Q8TDU6-GPBAR_HUMAN
Tissue specificity: Ubiquitously expressed. Expressed at higher level in spleen and placenta. Expressed at lower level in other tissues. In digestive tissues, it is expressed in stomach, duodenum, ileocecum, ileum, jejunum, ascending colon, transverse colon, descending colon, cecum and liver, but not in esophagus and rectum.
genes like me logo Genes that share expression patterns with GPBAR1: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for GPBAR1 Gene

Orthologs for GPBAR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPBAR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPBAR1 35
  • 86.42 (n)
  • 87.23 (a)
GPBAR1 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPBAR1 35
  • 85.86 (n)
  • 88.48 (a)
GPBAR1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpbar1 35
  • 83.13 (n)
  • 83.84 (a)
Gpbar1 16
Gpbar1 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPBAR1 35
  • 99.29 (n)
  • 99.39 (a)
GPBAR1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpbar1 35
  • 81.97 (n)
  • 82.37 (a)
oppossum
(Monodelphis domestica)
Mammalia GPBAR1 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPBAR1 36
  • 32 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii GPBAR1 (1 of 2) 36
  • 39 (a)
OneToMany
GPBAR1 (2 of 2) 36
  • 39 (a)
OneToMany
Species with no ortholog for GPBAR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPBAR1 Gene

ENSEMBL:
Gene Tree for GPBAR1 (if available)
TreeFam:
Gene Tree for GPBAR1 (if available)

Paralogs for GPBAR1 Gene

No data available for Paralogs for GPBAR1 Gene

Variants for GPBAR1 Gene

Sequence variations from dbSNP and Humsavar for GPBAR1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1567869 -- 218,262,012(-) TGAAC(A/G)TGGAG intron-variant
rs3731859 -- 218,259,499(+) TGCCC(A/G)ACCAG upstream-variant-2KB, utr-variant-5-prime
rs3795981 -- 218,261,366(+) TTTGT(C/G)GCTGT intron-variant
rs4674276 -- 218,258,057(+) gttca(A/T)gcaat upstream-variant-2KB
rs4674277 -- 218,258,058(+) ttcaa(G/T)caatt upstream-variant-2KB

Variation tolerance for GPBAR1 Gene

Residual Variation Intolerance Score: 80.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.82; 34.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPBAR1 Gene

HapMap Linkage Disequilibrium report
GPBAR1
Human Gene Mutation Database (HGMD)
GPBAR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GPBAR1 Gene

Disorders for GPBAR1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for GPBAR1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
functional diarrhea
sclerosing cholangitis
  • sclerosing cholangitis unspecified
polycystic liver disease
  • isolated autosomal dominant polycystic liver disease
cholangitis
- elite association

Relevant External Links for GPBAR1

Genetic Association Database (GAD)
GPBAR1
Human Genome Epidemiology (HuGE) Navigator
GPBAR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPBAR1
genes like me logo Genes that share disorders with GPBAR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPBAR1 Gene

Publications for GPBAR1 Gene

  1. Identification of membrane-type receptor for bile acids (M-BAR). (PMID: 12419312) Maruyama T. … Tanaka K. (Biochem. Biophys. Res. Commun. 2002) 2 23 67
  2. ERK activation and cell growth require CaM kinases in MCF-7 breast cancer cells. (PMID: 19763792) Schmitt J.M. … Davare M.A. (Mol. Cell. Biochem. 2010) 23 67
  3. Arrestin orchestrates crosstalk between G protein-coupled receptors to modulate the spatiotemporal activation of ERK MAPK. (PMID: 19926878) Cervantes D. … Xiang Y. (Circ. Res. 2010) 23 67
  4. GPCR signalling to the translation machinery. (PMID: 19887105) Musnier A. … CrAcpieux P. (Cell. Signal. 2010) 23 67
  5. An emerging role for kinase screening in GPCR drug discovery. (PMID: 20521219) Osmond R.I. … Dupriez V.J. (Curr. Opin. Mol. Ther. 2010) 23 67

Products for GPBAR1 Gene

Sources for GPBAR1 Gene

Back to Top

Content