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Aliases for GPBAR1 Gene

Aliases for GPBAR1 Gene

  • G Protein-Coupled Bile Acid Receptor 1 2 3 5
  • Membrane-Type Receptor For Bile Acids 3 4
  • G-Protein Coupled Receptor GPCR19 3 4
  • M-BAR 3 4
  • BG37 3 4
  • TGR5 3 4
  • G-Protein Coupled Bile Acid Receptor BG37 3
  • G-Protein Coupled Bile Acid Receptor 1 3
  • Membrane Bile Acid Receptor 3
  • HGPCR19 4
  • GPCR19 3
  • GPR131 3
  • HBG37 4

External Ids for GPBAR1 Gene

Previous GeneCards Identifiers for GPBAR1 Gene

  • GC02P217847
  • GC02P219090
  • GC02P219328
  • GC02P218949
  • GC02P218832
  • GC02P219124
  • GC02P210978

Summaries for GPBAR1 Gene

Entrez Gene Summary for GPBAR1 Gene

  • This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPBAR1 Gene

GPBAR1 (G Protein-Coupled Bile Acid Receptor 1) is a Protein Coding gene. Diseases associated with GPBAR1 include Sclerosing Cholangitis and Cholangitis. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled bile acid receptor activity.

UniProtKB/Swiss-Prot for GPBAR1 Gene

  • Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids.

Tocris Summary for GPBAR1 Gene

  • GPBA receptors (TGR5, GPBAR1, M-BAR) are G protein-coupled receptors (GPCRs) that are activated by bile acids. They are highly expressed in the gallbladder, ileum and colon, and are important in the regulation of glucose and lipid metabolism, and energy utilization.

Gene Wiki entry for GPBAR1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPBAR1 Gene

Genomics for GPBAR1 Gene

Regulatory Elements for GPBAR1 Gene

Enhancers for GPBAR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F218216 1.1 ENCODE 16.8 -38.9 -38911 9.0 HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 ENSG00000261338 GPBAR1 AAMP PNKD CXCR2P1 GC02M218215 TRY-ATA1-1
GH02F218228 1.1 Ensembl ENCODE 12.2 -29.3 -29274 3.7 HDGF CTCF KLF1 JUN ZNF175 CEBPG ZNF644 RELA YY1 E2F1 ENSG00000261338 GPBAR1 AAMP CXCR1 CATIP-AS1 GC02M218215 TRY-ATA1-1
GH02F218180 0.9 ENCODE 11.2 -78.5 -78451 1.6 ELF3 ARID4B SIN3A ZSCAN9 DNMT3B ZNF48 CHAMP1 RARA SLC30A9 ZNF766 ENSG00000261338 ARPC2 GPBAR1 AAMP FAM134A CXCR1 HMGB1P9
GH02F218331 1.5 FANTOM5 Ensembl ENCODE 5.5 +73.7 73675 3.2 HDGF ATF1 PKNOX1 ARNT CREB3L1 SIN3A ELK1 GATA2 CREB3 SMARCA4 ENSG00000261338 PNKD SLC11A1 AAMP CYP27A1 GPBAR1 ARPC2 TMBIM1 CXCR2 MIR6810
GH02F218281 1.5 FANTOM5 ENCODE 5.3 +30.7 30743 17.9 HDGF PKNOX1 ARNT MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ENSG00000261338 SLC11A1 RNF25 CNOT9 CTDSP1 MIR26B STK36 AAMP ARPC2 TMBIM1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPBAR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPBAR1 Gene

Chromosome:
2
Start:
218,259,496 bp from pter
End:
218,263,861 bp from pter
Size:
4,366 bases
Orientation:
Plus strand

Genomic View for GPBAR1 Gene

Genes around GPBAR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPBAR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPBAR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPBAR1 Gene

Proteins for GPBAR1 Gene

  • Protein details for GPBAR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDU6-GPBAR_HUMAN
    Recommended name:
    G-protein coupled bile acid receptor 1
    Protein Accession:
    Q8TDU6
    Secondary Accessions:
    • B3KV35

    Protein attributes for GPBAR1 Gene

    Size:
    330 amino acids
    Molecular mass:
    35248 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPBAR1 Gene

Post-translational modifications for GPBAR1 Gene

  • Glycosylation at Asn 4 and Asn 76

No data available for DME Specific Peptides for GPBAR1 Gene

Domains & Families for GPBAR1 Gene

Gene Families for GPBAR1 Gene

Protein Domains for GPBAR1 Gene

Suggested Antigen Peptide Sequences for GPBAR1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TDU6

UniProtKB/Swiss-Prot:

GPBAR_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPBAR1: view

Function for GPBAR1 Gene

Molecular function for GPBAR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids.

Gene Ontology (GO) - Molecular Function for GPBAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0038181 bile acid receptor activity IDA 12419312
GO:0038182 G-protein coupled bile acid receptor activity NAS 12419312
genes like me logo Genes that share ontologies with GPBAR1: view
genes like me logo Genes that share phenotypes with GPBAR1: view

Animal Models for GPBAR1 Gene

MGI Knock Outs for GPBAR1:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPBAR1

miRNA for GPBAR1 Gene

miRTarBase miRNAs that target GPBAR1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPBAR1 Gene

Localization for GPBAR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPBAR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPBAR1 gene
Compartment Confidence
plasma membrane 5
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for GPBAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12524422
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPBAR1: view

Pathways & Interactions for GPBAR1 Gene

genes like me logo Genes that share pathways with GPBAR1: view

Gene Ontology (GO) - Biological Process for GPBAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0038184 cell surface bile acid receptor signaling pathway IC 12524422
GO:2000810 regulation of bicellular tight junction assembly IEA --
genes like me logo Genes that share ontologies with GPBAR1: view

No data available for SIGNOR curated interactions for GPBAR1 Gene

Drugs & Compounds for GPBAR1 Gene

(20) Drugs for GPBAR1 Gene - From: ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
deoxycholic acid Approved Pharma Antagonist 40
chenodeoxycholic acid Approved Pharma Antagonist 32
cholic acid Approved Pharma Full agonist, Agonist 0
cyclic amp Experimental Pharma 0
Betulinic acid Pharma Full agonist, Agonist Anti-HIV and antitumor compound,pentacyclic triterpenoid, Antitumor and anti-HIV agent; activates NF-kappaB. Also TGR5 agonist 1

(6) Additional Compounds for GPBAR1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
TC-G 1005
1415407-60-1

(3) Tocris Compounds for GPBAR1 Gene

Compound Action Cas Number
Betulinic acid Antitumor and anti-HIV agent; activates NF-kappaB. Also TGR5 agonist 472-15-1
GPBAR-A GPBA receptor (TGR5) agonist 877052-79-4
TC-G 1005 Potent and selective GPBA receptor (TGR5) agonist 1415407-60-1

(4) ApexBio Compounds for GPBAR1 Gene

Compound Action Cas Number
Betulinic acid Anti-HIV and antitumor compound,pentacyclic triterpenoid 472-15-1
GPBAR-A agonist of bile acid receptor GPBAR1 877052-79-4
INT-777 TGR5 receptor agonist, potent and selective 1199796-29-6
TGR5 Receptor Agonist TGR5 G-protein receptor agonist 1197300-24-5
genes like me logo Genes that share compounds with GPBAR1: view

Transcripts for GPBAR1 Gene

Unigene Clusters for GPBAR1 Gene

G protein-coupled bile acid receptor 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPBAR1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c
SP1: - - - - -
SP2:
SP3: - -
SP4: -

Relevant External Links for GPBAR1 Gene

GeneLoc Exon Structure for
GPBAR1
ECgene alternative splicing isoforms for
GPBAR1

Expression for GPBAR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPBAR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPBAR1 Gene

This gene is overexpressed in Whole Blood (x10.9), Adipose - Visceral (Omentum) (x7.4), and Adipose - Subcutaneous (x7.0).

NURSA nuclear receptor signaling pathways regulating expression of GPBAR1 Gene:

GPBAR1

SOURCE GeneReport for Unigene cluster for GPBAR1 Gene:

Hs.160954

mRNA Expression by UniProt/SwissProt for GPBAR1 Gene:

Q8TDU6-GPBAR_HUMAN
Tissue specificity: Ubiquitously expressed. Expressed at higher level in spleen and placenta. Expressed at lower level in other tissues. In digestive tissues, it is expressed in stomach, duodenum, ileocecum, ileum, jejunum, ascending colon, transverse colon, descending colon, cecum and liver, but not in esophagus and rectum.
genes like me logo Genes that share expression patterns with GPBAR1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for GPBAR1 Gene

Orthologs for GPBAR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPBAR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPBAR1 34 35
  • 99.29 (n)
cow
(Bos Taurus)
Mammalia GPBAR1 34 35
  • 86.42 (n)
dog
(Canis familiaris)
Mammalia GPBAR1 34 35
  • 85.86 (n)
mouse
(Mus musculus)
Mammalia Gpbar1 34 16 35
  • 83.13 (n)
rat
(Rattus norvegicus)
Mammalia Gpbar1 34
  • 81.97 (n)
oppossum
(Monodelphis domestica)
Mammalia GPBAR1 35
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPBAR1 35
  • 32 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii GPBAR1 (1 of 2) 35
  • 39 (a)
OneToMany
GPBAR1 (2 of 2) 35
  • 39 (a)
OneToMany
Species where no ortholog for GPBAR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPBAR1 Gene

ENSEMBL:
Gene Tree for GPBAR1 (if available)
TreeFam:
Gene Tree for GPBAR1 (if available)

Paralogs for GPBAR1 Gene

No data available for Paralogs for GPBAR1 Gene

Variants for GPBAR1 Gene

Sequence variations from dbSNP and Humsavar for GPBAR1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10190292 -- 218,262,139(+) CTGCT(C/T)ACTGA intron-variant, utr-variant-5-prime
rs10203642 -- 218,259,046(+) ATTCC(A/G)TGCCA upstream-variant-2KB
rs1051165 -- 218,264,315(-) CTTCA(A/G)AGGGA intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1051182 -- 218,264,198(-) AGTCT(C/T)TGGGG intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1051183 -- 218,264,178(-) AGGAA(A/G)AGATA intron-variant, downstream-variant-500B, utr-variant-3-prime

Variation tolerance for GPBAR1 Gene

Residual Variation Intolerance Score: 80.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.82; 34.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPBAR1 Gene

Human Gene Mutation Database (HGMD)
GPBAR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPBAR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GPBAR1 Gene

Disorders for GPBAR1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for GPBAR1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
sclerosing cholangitis
  • primary sclerosing cholangitis
cholangitis
functional diarrhea
ocular albinism
  • albinism, ocular
leber congenital amaurosis
  • lca
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GPBAR1

Genetic Association Database (GAD)
GPBAR1
Human Genome Epidemiology (HuGE) Navigator
GPBAR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPBAR1
genes like me logo Genes that share disorders with GPBAR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPBAR1 Gene

Publications for GPBAR1 Gene

  1. Identification of membrane-type receptor for bile acids (M-BAR). (PMID: 12419312) Maruyama T. … Tanaka K. (Biochem. Biophys. Res. Commun. 2002) 2 3 4 22 64
  2. Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis. (PMID: 20811628) Hov J.R. … Karlsen T.H. (PLoS ONE 2010) 3 46 64
  3. Genome-wide association analysis in primary sclerosing cholangitis. (PMID: 19944697) Karlsen T.H. … Schreiber S. (Gastroenterology 2010) 3 46 64
  4. Preliminary report: genetic variation within the GPBAR1 gene is not associated with metabolic traits in white subjects at an increased risk for type 2 diabetes mellitus. (PMID: 19716570) MA1ssig K. … HAoring H.U. (Metab. Clin. Exp. 2009) 3 46 64
  5. Involvement of membrane-type bile acid receptor M-BAR/TGR5 in bile acid-induced activation of epidermal growth factor receptor and mitogen-activated protein kinases in gastric carcinoma cells. (PMID: 17214962) Yasuda H. … Yoshiba M. (Biochem. Biophys. Res. Commun. 2007) 3 22 64

Products for GPBAR1 Gene

Sources for GPBAR1 Gene

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