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Aliases for GPBAR1 Gene

Aliases for GPBAR1 Gene

  • G Protein-Coupled Bile Acid Receptor 1 2 3 5
  • Membrane-Type Receptor For Bile Acids 3 4
  • G-Protein Coupled Receptor GPCR19 3 4
  • M-BAR 3 4
  • BG37 3 4
  • TGR5 3 4
  • G-Protein Coupled Bile Acid Receptor BG37 3
  • Membrane Bile Acid Receptor 3
  • HGPCR19 4
  • GPCR19 3
  • GPR131 3
  • HBG37 4

External Ids for GPBAR1 Gene

Previous GeneCards Identifiers for GPBAR1 Gene

  • GC02P217847
  • GC02P219090
  • GC02P219328
  • GC02P218949
  • GC02P218832
  • GC02P219124
  • GC02P210978

Summaries for GPBAR1 Gene

Entrez Gene Summary for GPBAR1 Gene

  • This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPBAR1 Gene

GPBAR1 (G Protein-Coupled Bile Acid Receptor 1) is a Protein Coding gene. Diseases associated with GPBAR1 include Sclerosing Cholangitis and Functional Diarrhea. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled bile acid receptor activity.

UniProtKB/Swiss-Prot for GPBAR1 Gene

  • Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids.

Tocris Summary for GPBAR1 Gene

Gene Wiki entry for GPBAR1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPBAR1 Gene

Genomics for GPBAR1 Gene

Regulatory Elements for GPBAR1 Gene

Enhancers for GPBAR1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPBAR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPBAR1 Gene

218,259,496 bp from pter
218,263,861 bp from pter
4,366 bases
Plus strand

Genomic View for GPBAR1 Gene

Genes around GPBAR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPBAR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPBAR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPBAR1 Gene

Proteins for GPBAR1 Gene

  • Protein details for GPBAR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G-protein coupled bile acid receptor 1
    Protein Accession:
    Secondary Accessions:
    • B3KV35

    Protein attributes for GPBAR1 Gene

    330 amino acids
    Molecular mass:
    35248 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPBAR1 Gene

Proteomics data for GPBAR1 Gene at MOPED

Post-translational modifications for GPBAR1 Gene

  • Glycosylation at Asn 4 and Asn 76

Other Protein References for GPBAR1 Gene

No data available for DME Specific Peptides for GPBAR1 Gene

Domains & Families for GPBAR1 Gene

Gene Families for GPBAR1 Gene

Protein Domains for GPBAR1 Gene


Suggested Antigen Peptide Sequences for GPBAR1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPBAR1: view

Function for GPBAR1 Gene

Molecular function for GPBAR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids.
genes like me logo Genes that share phenotypes with GPBAR1: view

Animal Models for GPBAR1 Gene

MGI Knock Outs for GPBAR1:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPBAR1

CRISPR Products

miRNA for GPBAR1 Gene

miRTarBase miRNAs that target GPBAR1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPBAR1 Gene

Localization for GPBAR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPBAR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GPBAR1 Gene COMPARTMENTS Subcellular localization image for GPBAR1 gene
Compartment Confidence
plasma membrane 5
nucleus 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for GPBAR1 Gene

Pathways & Interactions for GPBAR1 Gene

genes like me logo Genes that share pathways with GPBAR1: view

Interacting Proteins for GPBAR1 Gene

Gene Ontology (GO) - Biological Process for GPBAR1 Gene


No data available for SIGNOR curated interactions for GPBAR1 Gene

Drugs & Compounds for GPBAR1 Gene

(16) Drugs for GPBAR1 Gene - From: ApexBio, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
deoxycholic acid Approved Pharma Antagonist 39
chenodeoxycholic acid Approved Pharma Antagonist 27
cholic acid Approved Pharma Full agonist, Agonist 0
cyclic amp Experimental Pharma 0
Betulinic acid Pharma Full agonist, Agonist Anti-HIV and antitumor compound,pentacyclic triterpenoid, Antitumor and anti-HIV agent; activates NF-kappaB. Also TGR5 agonist 1

(6) Additional Compounds for GPBAR1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for GPBAR1 Gene

Compound Action Cas Number
Betulinic acid Anti-HIV and antitumor compound,pentacyclic triterpenoid 472-15-1
genes like me logo Genes that share compounds with GPBAR1: view

Transcripts for GPBAR1 Gene

Unigene Clusters for GPBAR1 Gene

G protein-coupled bile acid receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPBAR1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c
SP1: - - - - -
SP3: - -
SP4: -

Relevant External Links for GPBAR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPBAR1 Gene

mRNA expression in normal human tissues for GPBAR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPBAR1 Gene

This gene is overexpressed in Whole Blood (x10.9), Adipose - Visceral (Omentum) (x7.4), and Adipose - Subcutaneous (x7.0).

SOURCE GeneReport for Unigene cluster for GPBAR1 Gene Hs.160954

mRNA Expression by UniProt/SwissProt for GPBAR1 Gene

Tissue specificity: Ubiquitously expressed. Expressed at higher level in spleen and placenta. Expressed at lower level in other tissues. In digestive tissues, it is expressed in stomach, duodenum, ileocecum, ileum, jejunum, ascending colon, transverse colon, descending colon, cecum and liver, but not in esophagus and rectum.
genes like me logo Genes that share expression patterns with GPBAR1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for GPBAR1 Gene

Orthologs for GPBAR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPBAR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPBAR1 35
  • 86.42 (n)
  • 87.23 (a)
  • 87 (a)
(Canis familiaris)
Mammalia GPBAR1 35
  • 85.86 (n)
  • 88.48 (a)
  • 88 (a)
(Mus musculus)
Mammalia Gpbar1 35
  • 83.13 (n)
  • 83.84 (a)
Gpbar1 16
Gpbar1 36
  • 84 (a)
(Pan troglodytes)
Mammalia GPBAR1 35
  • 99.29 (n)
  • 99.39 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Gpbar1 35
  • 81.97 (n)
  • 82.37 (a)
(Monodelphis domestica)
Mammalia GPBAR1 36
  • 74 (a)
(Anolis carolinensis)
Reptilia GPBAR1 36
  • 32 (a)
(Danio rerio)
Actinopterygii GPBAR1 (1 of 2) 36
  • 39 (a)
GPBAR1 (2 of 2) 36
  • 39 (a)
Species with no ortholog for GPBAR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPBAR1 Gene

Gene Tree for GPBAR1 (if available)
Gene Tree for GPBAR1 (if available)

Paralogs for GPBAR1 Gene

No data available for Paralogs for GPBAR1 Gene

Variants for GPBAR1 Gene

Sequence variations from dbSNP and Humsavar for GPBAR1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1567869 -- 218,262,012(-) TGAAC(A/G)TGGAG intron-variant
rs3731859 -- 218,259,499(+) TGCCC(A/G)ACCAG upstream-variant-2KB, utr-variant-5-prime
rs6746791 -- 218,258,049(+) cttcc(C/T)gggtt upstream-variant-2KB
rs3795981 -- 218,261,366(+) TTTGT(C/G)GCTGT intron-variant
rs5838688 -- 218,262,931(+) CATTG(-/C)CCACA reference, frameshift-variant

Variation tolerance for GPBAR1 Gene

Residual Variation Intolerance Score: 80.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.82; 34.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPBAR1 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GPBAR1 Gene

Disorders for GPBAR1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for GPBAR1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
sclerosing cholangitis
  • fibrosing cholangitis
functional diarrhea
polycystic liver disease
  • isolated autosomal dominant polycystic liver disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GPBAR1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GPBAR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPBAR1 Gene

Publications for GPBAR1 Gene

  1. Identification of membrane-type receptor for bile acids (M-BAR). (PMID: 12419312) Maruyama T. … Tanaka K. (Biochem. Biophys. Res. Commun. 2002) 2 3 4 23 67
  2. Involvement of membrane-type bile acid receptor M-BAR/TGR5 in bile acid-induced activation of epidermal growth factor receptor and mitogen-activated protein kinases in gastric carcinoma cells. (PMID: 17214962) Yasuda H. … Yoshiba M. (Biochem. Biophys. Res. Commun. 2007) 3 23
  3. Cross-talk between G protein-coupled receptor and epidermal growth factor receptor signaling pathways contributes to growth and invasion of head and neck squamous cell carcinoma. (PMID: 17178880) Thomas S.M. … Grandis J.R. (Cancer Res. 2006) 3 23
  4. Cystathionine I^-lyase, a H2S-generating enzyme, is a GPBAR1-regulated gene and contributes to vasodilation caused by secondary bile acids. (PMID: 25934094) Renga B. … Fiorucci S. (Am. J. Physiol. Heart Circ. Physiol. 2015) 3
  5. TGR5 in the Cholangiociliopathies. (PMID: 26045278) Masyuk T.V. … LaRusso N.F. (Dig Dis 2015) 3

Products for GPBAR1 Gene

Sources for GPBAR1 Gene