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Aliases & Descriptions for GPBAR1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases BG37 1 , 2 , 3 , 5 GPCR 1 , 2 GPCR19 1 , 2 GPR131 1 , 2 M-BAR 1 , 2 , 3 MGC40597 1 , 2 TGR5 1 , 2 , 3 hBG37 3 hGPCR19 3
Descriptions G protein-coupled bile acid receptor 1 2 G-protein coupled bile acid receptor BG37 2 Membrane-type receptor for bile acids 2 , 3 membrane bile acid receptor 2
Search outside databases for aliases for GPBAR1 genePrevious GC identifers: GC02P217847 GC02P219090 GC02P219328 GC02P218949
Summaries for GPBAR1 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for GPBAR1 : This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzymefunctions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR withbile acids induces the production of intracellular cAMP, activation of a MAP kinase signalingpathway, and internalization of the receptor. The receptor is implicated in the suppression ofmacrophage functions and regulation of energy homeostasis by bile acids. Alternative splicingresults in multiple transcript variants encoding the same protein. [provided by RefSeq] UniProtKB/Swiss-Prot: GPBAR_HUMAN, Q8TDU6 Function : Receptor for bile acid. Bile acid-binding induces its internalization, activation ofextracellular signal-regulated kinase and intracellular cAMP production. May be involved in thesuppression of macrophage functions by bile acids
Gene Wiki entry for GPBAR1 (G_protein-coupled_bile_acid_receptor)
Genomic Location for GPBAR1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the GPBAR1 gene Entrez Gene cytogenetic band: 2q35 Ensembl cytogenetic band: 2q35 HGNC cytogenetic band: 2q35 GPBAR1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure
GeneLoc location for GC02P218832:
(about GC identifiers )
Start:
218,833,983 bp from pter
End:
218,836,826 bp from pter
Size:
2,844 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000002.10 NT_005403.16 Proteins for GPBAR1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: GPBAR_HUMAN, Q8TDU6 (See
protein sequence )Recommended Name: G-protein coupled bile acid receptor 1 Size : 330 amino acids; 35248 Da
Subcellular location : Cell membrane; Multi-pass membrane protein
REFSEQ proteins (3 alternative transcripts):
NP_001070659.1 NP_001070662.1 NP_733800.1 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 2 Gene Ontology (GO) cellular component terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005886 plasma membrane
IEA -- GO:0016021 integral to membrane
IEA --
About this table Antibodies for GPBAR1: Assays for GPBAR1:
Protein
Domains/ Families for GPBAR1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q8TDU6 ProtoNet protein and cluster: Q8TDU6
UniProtKB/Swiss-Prot: GPBAR_HUMAN, Q8TDU6 Similarity : Belongs to the G-protein coupled receptor 1 family
Gene Function for GPBAR1
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_170699 Applied Biosystems Silencer ® siRNAs for GPBAR1 Sigma-Aldrich siRNA and siRNA Panels for GPBAR1 Sigma-Aldrich shRNA Panels and shRNA for GPBAR1 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_001077191                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_001077191                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_001077191  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_170699 UniProtKB/Swiss-Prot: GPBAR_HUMAN, Q8TDU6 Function : Receptor for bile acid. Bile acid-binding induces its internalization, activation ofextracellular signal-regulated kinase and intracellular cAMP production. May be involved in thesuppression of macrophage functions by bile acids
5 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Gpbar1) :2 Gene Ontology (GO) molecular function terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0004872 receptor activity
IEA -- GO:0004930 G-protein coupled receptor activity
IEA --
About this table
Pathways & Interactions for GPBAR1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for GPBAR1 --2 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0007165 signal transduction
IEA -- GO:0007186 G-protein coupled receptor protein signaling pathway
IEA --
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Drugs & Compounds for GPBAR1 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for GPBAR1 8 Novoseek chemical compound relationships for GPBAR1 gene
Compound
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine
53.37
19
11502566 (1), 16620963 (1), 17274683 (1), 15456867 (1) (see all 19 )
threonine
44.19
5
17995450 (1), 11399057 (1), 15375171 (1), 11641411 (1) (see all 5 )
sphingosine
33.16
2
16164409 (1), 14623109 (1)
deoxycholic acid
22.22
2
17214962 (2)
lysine
4.56
1
15713849 (1)
phospholipid
0.00
2
15110780 (1), 18931035 (1)
lipid
0.00
3
15556605 (1), 17070497 (1), 19418628 (1)
calcium
0.00
11
19035847 (4), 15598880 (1), 16110482 (1), 8734454 (1) (see all 5 )
About this table
Transcripts for GPBAR1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_170699 Sigma-Aldrich siRNA and siRNA Panels for GPBAR1 Sigma-Aldrich shRNA Panels and shRNA for GPBAR1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001077191 NM_001077194 NM_170699
REFSEQ mRNAs for GPBAR1 gene (3 alternative transcripts): NM_001077191.1 NM_001077194.1 NM_170699.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001077191 NM_001077194 NM_170699
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_001077191                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_001077191                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_001077191  
Additional cDNA sequence: AB086170.1 AB089307.1 AK122658.1 AK122660.1 BC033625.1 CR604439.1 CR625402.1
6 DOTS entries : DT.95261319 DT.100721867 DT.100747103 DT.101981636 DT.100747104 DT.100768004
24/32 AceView cDNA sequences (see all 32
):CR625402 CR604439 AA595679 BX369250 NM_170699 CD370746 AB086170 BI834364 AK122660 AK122658 BX366596 BC033625 BI199349 BX365038 BX094903 BF312517 BG698138 BI833418 AB089307 BI522077 BF207290 BX366595 AI391439 AA100813
highest scoring ESTs for GPBAR1 :AA595679 AB086170 AB089307 AK122658 AK122660 BC033625 BE819289 BF207290 BF312517 BI199349
Unigene Cluster for GPBAR1: G protein-coupled bile acid receptor 1 Hs.160954 [show with all ESTs ] Unigene Representative Sequence: NM_001077191 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for GPBAR1 ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c SP1 :   -   -   -   -   -       SP2 :                 SP3 :         -   -       SP4 :         -        
About this scheme ECgene alternative splicing isoforms for GPBAR1 1 Ensembl transcript including schematic representation : ENST00000354867
Expression for GPBAR1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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GPBAR1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for GPBAR1 1 / 2 / 3
2 probe-sets matching GPBAR1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GGGCTGGGCGSOURCE GeneReport for Unigene cluster: Hs.160954 UniProtKB/Swiss-Prot: GPBAR_HUMAN, Q8TDU6 Tissue specificity : Ubiquitously expressed. Expressed at higher level in spleen and placenta.Expressed at lower level in other tissues. In digestive tissues, it is expressed in stomach,duodenum, ileocecum, ileum, jejunum, ascending colon, transverse colon, descending colon, cecumand liver, but not in esophagus and rectum
Orthologs for GPBAR1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for GPBAR1 gene from 5/6 species (see all 6
)
About this table Species with no ortholog for GPBAR1 ENSEMBL Gene Tree for GPBAR1 Paralogs for GPBAR1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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--
SNPs/Variants for GPBAR1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for GPBAR1 (up to first 250kb)
Disorders & Mutations for GPBAR1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 610147 4 Novoseek disease relationships for GPBAR1 gene
About this table
Medical News for GPBAR1 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for GPBAR1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/171 PubMed articles for GPBAR1 gene (see all 171
): Identification of membrane-type receptor for bile acids (M-BAR). (PubMed id 12419312) 1, 2, 3, 4 Maruyama T.... Tanaka K. (2002) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) A G protein-coupled receptor responsive to bile acids. (PubMed id 12524422) 3, 4 Kawamata Y....Fujino M. (2003) Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878) 3, 4 Takeda S.... Mitaku S. (2002) Cross-talk between G protein-coupled receptor and epidermal growth factor receptor signaling pathways contributes to growth and invasion of head and neck squamous cell carcinoma. (PubMed id 17178880) 1, 3 Thomas S.M....Grandis J.R. (2006) Involvement of membrane-type bile acid receptor M-BAR/TGR5 in bile acid-induced activation of epidermal growth factor receptor and mitogen-activated protein kinases in gastric carcinoma cells. (PubMed id 17214962) 1, 3 Yasuda H....Yoshiba M. (2007) The G-protein coupled bile salt receptor TGR5 is expressed in liver sinusoidal endothelial cells. (PubMed id 17326144) 3 Keitel V....Kubitz R. (2007) Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. (PubMed id 16400329) 3 Watanabe M....Auwerx J. (2006) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3 Ota T....Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002)
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Genome Databases showing GPBAR1
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing GPBAR1
(According to HUGE )
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Specialized Databases showing GPBAR1 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for GPBAR1 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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