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Aliases for GPATCH4 Gene

Aliases for GPATCH4 Gene

  • G-Patch Domain Containing 4 2 3 5
  • GPATC4 3 4
  • G Patch Domain-Containing Protein 4 3

External Ids for GPATCH4 Gene

Previous HGNC Symbols for GPATCH4 Gene

  • GPATC4

Previous GeneCards Identifiers for GPATCH4 Gene

  • GC01M154831
  • GC01M127921

Summaries for GPATCH4 Gene

GeneCards Summary for GPATCH4 Gene

GPATCH4 (G-Patch Domain Containing 4) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and poly(A) RNA binding.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPATCH4 Gene

Genomics for GPATCH4 Gene

Regulatory Elements for GPATCH4 Gene

Enhancers for GPATCH4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G156456 1.8 FANTOM5 ENCODE dbSUPER 11.1 +144.1 144120 2.7 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF263 KIAA0907 RRNAD1 ENSG00000271267 LOC246784 ARHGEF2 C1orf61 MIR9-1 SSR2 NAXE GPATCH4
GH01G156460 1.4 Ensembl ENCODE dbSUPER 11.1 +139.7 139734 1.7 PKNOX1 ATF1 CBX3 TBL1XR1 ZNF133 CHAMP1 TCF12 ZNF766 EGR1 GATA2 C1orf61 MIR9-1 NAXE GPATCH4 HAPLN2 MRPL24 HDGF GC01M156440 GC01M156484 ENSG00000206651
GH01G156581 1.1 Ensembl ENCODE 12.3 +18.6 18630 3.4 HDGF RAD21 RFX5 GLIS2 EGR1 ZNF366 ZNF143 FOS DEK ZNF654 TTC24 NAXE GPATCH4 SMG5 HAPLN2
GH01G156461 1.2 ENCODE dbSUPER 11.1 +140.7 140739 0.0 PKNOX1 ATF1 ARNT TCF12 ZNF766 ELK1 GATA2 JUNB NCOA1 SMARCA4 C1orf61 MIR9-1 NAXE GPATCH4 HAPLN2 MRPL24 HDGF GC01M156440 GC01M156484 ENSG00000206651
GH01G156599 1.1 ENCODE 11.6 +0.3 250 3.5 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YBX1 FEZF1 ZNF2 YY1 ZNF207 NAXE GPATCH4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPATCH4 on UCSC Golden Path with GeneCards custom track

Promoters for GPATCH4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000014225 96 1201 CREB3L1 ARID4B SIN3A DMAP1 YBX1 FEZF1 ZNF2 YY1 ZNF207 ZNF143

Genomic Location for GPATCH4 Gene

Chromosome:
1
Start:
156,594,308 bp from pter
End:
156,601,496 bp from pter
Size:
7,189 bases
Orientation:
Minus strand

Genomic View for GPATCH4 Gene

Genes around GPATCH4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPATCH4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPATCH4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPATCH4 Gene

Proteins for GPATCH4 Gene

  • Protein details for GPATCH4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T3I0-GPTC4_HUMAN
    Recommended name:
    G patch domain-containing protein 4
    Protein Accession:
    Q5T3I0
    Secondary Accessions:
    • Q5T3I1
    • Q6ZUE7
    • Q8IWG8
    • Q9NXH4

    Protein attributes for GPATCH4 Gene

    Size:
    446 amino acids
    Molecular mass:
    50381 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH40147.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI13052.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13053.1; Type=Miscellaneous discrepancy; Note=The C-terminal sequence differs due to frameshift variations.; Evidence={ECO:0000305};

    Alternative splice isoforms for GPATCH4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPATCH4 Gene

Post-translational modifications for GPATCH4 Gene

  • Ubiquitination at posLast=2121
  • Modification sites at PhosphoSitePlus

Other Protein References for GPATCH4 Gene

No data available for DME Specific Peptides for GPATCH4 Gene

Domains & Families for GPATCH4 Gene

Gene Families for GPATCH4 Gene

Protein Domains for GPATCH4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GPATCH4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GPATCH4: view

No data available for UniProtKB/Swiss-Prot for GPATCH4 Gene

Function for GPATCH4 Gene

Gene Ontology (GO) - Molecular Function for GPATCH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GPATCH4: view
genes like me logo Genes that share phenotypes with GPATCH4: view

Animal Model Products

CRISPR Products

miRNA for GPATCH4 Gene

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPATCH4 Gene

Localization for GPATCH4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPATCH4 gene
Compartment Confidence
nucleus 4
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GPATCH4 Gene

Pathways & Interactions for GPATCH4 Gene

SuperPathways for GPATCH4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPATCH4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GPATCH4 Gene

Drugs & Compounds for GPATCH4 Gene

No Compound Related Data Available

Transcripts for GPATCH4 Gene

Unigene Clusters for GPATCH4 Gene

G patch domain containing 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPATCH4 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6
SP1:
SP2: -
SP3:

Relevant External Links for GPATCH4 Gene

GeneLoc Exon Structure for
GPATCH4
ECgene alternative splicing isoforms for
GPATCH4

Expression for GPATCH4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPATCH4 Gene

Protein differential expression in normal tissues from HIPED for GPATCH4 Gene

This gene is overexpressed in Lung (55.9) and Heart (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GPATCH4 Gene



Protein tissue co-expression partners for GPATCH4 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPATCH4 Gene:

GPATCH4

SOURCE GeneReport for Unigene cluster for GPATCH4 Gene:

Hs.193832

Evidence on tissue expression from TISSUES for GPATCH4 Gene

  • Intestine(4.3)
  • Kidney(4.3)
  • Nervous system(2.4)
  • Liver(2)
  • Lung(2)
genes like me logo Genes that share expression patterns with GPATCH4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPATCH4 Gene

Orthologs for GPATCH4 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPATCH4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPATCH4 34 35
  • 99.35 (n)
cow
(Bos Taurus)
Mammalia GPATCH4 34 35
  • 84.34 (n)
dog
(Canis familiaris)
Mammalia GPATCH4 34 35
  • 81.74 (n)
rat
(Rattus norvegicus)
Mammalia Gpatch4 34
  • 80.14 (n)
mouse
(Mus musculus)
Mammalia Gpatch4 34 16 35
  • 75.21 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 58 (a)
OneToMany
-- 35
  • 55 (a)
OneToMany
chicken
(Gallus gallus)
Aves GPATCH4 35
  • 33 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPATCH4 35
  • 33 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75931 34
zebrafish
(Danio rerio)
Actinopterygii gpatch4 35
  • 27 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG15561 35
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
OneToOne
Species where no ortholog for GPATCH4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPATCH4 Gene

ENSEMBL:
Gene Tree for GPATCH4 (if available)
TreeFam:
Gene Tree for GPATCH4 (if available)

Paralogs for GPATCH4 Gene

(1) SIMAP similar genes for GPATCH4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with GPATCH4: view

No data available for Paralogs for GPATCH4 Gene

Variants for GPATCH4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for GPATCH4 Gene

GPTC4_HUMAN-Q5T3I0
This gene contains polymorphic substitutions in the last exon causing a frameshift variant C-terminal sequence compared to the official human genome. However, this variant sequence is in agreement with ortholog sequences.

Sequence variations from dbSNP and Humsavar for GPATCH4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs886041062 Pathogenic 156,594,021(+) CTGGA(A/GAAG)AAGTA intron-variant, downstream-variant-500B, cds-indel
rs886041063 Pathogenic 156,593,960(+) ATCTG(-/C)AACCC intron-variant, reference, frameshift-variant
rs1000300307 -- 156,602,292(+) TTGGT(A/G)CTGGG intron-variant, upstream-variant-2KB
rs1001226519 -- 156,602,909(+) CTTAG(C/T)GCCCC intron-variant, upstream-variant-2KB
rs1001311129 -- 156,596,201(+) AAACA(G/T)TCCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPATCH4 Gene

Variant ID Type Subtype PubMed ID
nsv523181 CNV loss 19592680

Variation tolerance for GPATCH4 Gene

Residual Variation Intolerance Score: 78.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.86; 48.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPATCH4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPATCH4

Disorders for GPATCH4 Gene

Relevant External Links for GPATCH4

Genetic Association Database (GAD)
GPATCH4
Human Genome Epidemiology (HuGE) Navigator
GPATCH4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPATCH4

No disorders were found for GPATCH4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPATCH4 Gene

Publications for GPATCH4 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  2. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang A.G. … Kim N.S. (Biochem. Biophys. Res. Commun. 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64

Products for GPATCH4 Gene

Sources for GPATCH4 Gene

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