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Aliases for GPATCH4 Gene

Aliases for GPATCH4 Gene

  • G Patch Domain Containing 4 2 3
  • GPATC4 3 4

External Ids for GPATCH4 Gene

Previous HGNC Symbols for GPATCH4 Gene

  • GPATC4

Previous GeneCards Identifiers for GPATCH4 Gene

  • GC01M154831
  • GC01M127921

Summaries for GPATCH4 Gene

GeneCards Summary for GPATCH4 Gene

GPATCH4 (G Patch Domain Containing 4) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and poly(A) RNA binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPATCH4 Gene

Genomics for GPATCH4 Gene

Regulatory Elements for GPATCH4 Gene

Genomic Location for GPATCH4 Gene

Chromosome:
1
Start:
156,594,308 bp from pter
End:
156,601,496 bp from pter
Size:
7,189 bases
Orientation:
Minus strand

Genomic View for GPATCH4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPATCH4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPATCH4 Gene

Proteins for GPATCH4 Gene

  • Protein details for GPATCH4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T3I0-GPTC4_HUMAN
    Recommended name:
    G patch domain-containing protein 4
    Protein Accession:
    Q5T3I0
    Secondary Accessions:
    • Q5T3I1
    • Q6ZUE7
    • Q8IWG8
    • Q9NXH4

    Protein attributes for GPATCH4 Gene

    Size:
    446 amino acids
    Molecular mass:
    50381 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH40147.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI13052.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13053.1; Type=Miscellaneous discrepancy; Note=The C-terminal sequence differs due to frameshift variations.; Evidence={ECO:0000305};

    Alternative splice isoforms for GPATCH4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPATCH4 Gene

Proteomics data for GPATCH4 Gene at MOPED

Post-translational modifications for GPATCH4 Gene

  • Ubiquitination at Lys 21
  • Modification sites at PhosphoSitePlus

Other Protein References for GPATCH4 Gene

No data available for DME Specific Peptides for GPATCH4 Gene

Domains & Families for GPATCH4 Gene

Gene Families for GPATCH4 Gene

Protein Domains for GPATCH4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GPATCH4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T3I0

UniProtKB/Swiss-Prot:

GPTC4_HUMAN :
  • Contains 1 G-patch domain.
Domain:
  • Contains 1 G-patch domain.
genes like me logo Genes that share domains with GPATCH4: view

Function for GPATCH4 Gene

Gene Ontology (GO) - Molecular Function for GPATCH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with GPATCH4: view

Phenotypes for GPATCH4 Gene

genes like me logo Genes that share phenotypes with GPATCH4: view

Animal Model Products

CRISPR Products

miRNA for GPATCH4 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPATCH4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GPATCH4 Gene

Localization for GPATCH4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPATCH4 Gene COMPARTMENTS Subcellular localization image for GPATCH4 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GPATCH4 Gene

Pathways & Interactions for GPATCH4 Gene

SuperPathways for GPATCH4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPATCH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation --
genes like me logo Genes that share ontologies with GPATCH4: view

No data available for Pathways by source and SIGNOR curated interactions for GPATCH4 Gene

Drugs & Compounds for GPATCH4 Gene

No Compound Related Data Available

Transcripts for GPATCH4 Gene

Unigene Clusters for GPATCH4 Gene

G patch domain containing 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPATCH4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPATCH4 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6
SP1:
SP2: -
SP3:

Relevant External Links for GPATCH4 Gene

GeneLoc Exon Structure for
GPATCH4
ECgene alternative splicing isoforms for
GPATCH4

Expression for GPATCH4 Gene

mRNA expression in normal human tissues for GPATCH4 Gene

Protein differential expression in normal tissues from HIPED for GPATCH4 Gene

This gene is overexpressed in Lung (55.9) and Heart (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GPATCH4 Gene



SOURCE GeneReport for Unigene cluster for GPATCH4 Gene Hs.193832

genes like me logo Genes that share expression patterns with GPATCH4: view

Protein tissue co-expression partners for GPATCH4 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GPATCH4 Gene

Orthologs for GPATCH4 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPATCH4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPATCH4 35
  • 84.34 (n)
  • 76.08 (a)
GPATCH4 36
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPATCH4 35
  • 81.74 (n)
  • 74.2 (a)
GPATCH4 36
  • 55 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpatch4 35
  • 75.21 (n)
  • 63.79 (a)
Gpatch4 16
Gpatch4 36
  • 52 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPATCH4 35
  • 99.35 (n)
  • 98.88 (a)
GPATCH4 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpatch4 35
  • 80.14 (n)
  • 70.21 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 55 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
chicken
(Gallus gallus)
Aves GPATCH4 36
  • 33 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPATCH4 36
  • 33 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75931 35
zebrafish
(Danio rerio)
Actinopterygii gpatch4 36
  • 27 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG15561 36
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToOne
Species with no ortholog for GPATCH4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPATCH4 Gene

ENSEMBL:
Gene Tree for GPATCH4 (if available)
TreeFam:
Gene Tree for GPATCH4 (if available)

Paralogs for GPATCH4 Gene

(1) SIMAP similar genes for GPATCH4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with GPATCH4: view

No data available for Paralogs for GPATCH4 Gene

Variants for GPATCH4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for GPATCH4 Gene

Q5T3I0-GPTC4_HUMAN
This gene contains polymorphic substitutions in the last exon causing a frameshift variant C-terminal sequence compared to the official human genome. However, this variant sequence is in agreement with ortholog sequences

Sequence variations from dbSNP and Humsavar for GPATCH4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs8937 -- 156,596,095(+) GTTCG(A/C)CCCTC reference, synonymous-codon
rs879461 -- 156,597,704(+) ATAAT(C/T)TCTCA intron-variant
rs1063287 -- 156,596,422(-) TGCAG(A/T)GATGA missense, reference
rs1063288 -- 156,596,419(-) AGTGA(A/T)GACGA missense, reference
rs1130058 -- 156,596,397(-) CCAAG(C/T)CCCCA missense, reference

Structural Variations from Database of Genomic Variants (DGV) for GPATCH4 Gene

Variant ID Type Subtype PubMed ID
nsv523181 CNV Loss 19592680
nsv872472 CNV Loss 21882294

Variation tolerance for GPATCH4 Gene

Residual Variation Intolerance Score: 78.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.86; 48.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPATCH4 Gene

HapMap Linkage Disequilibrium report
GPATCH4

Disorders for GPATCH4 Gene

Relevant External Links for GPATCH4

Genetic Association Database (GAD)
GPATCH4
Human Genome Epidemiology (HuGE) Navigator
GPATCH4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPATCH4
genes like me logo Genes that share disorders with GPATCH4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPATCH4 Gene

Publications for GPATCH4 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  4. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 67
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67

Products for GPATCH4 Gene

Sources for GPATCH4 Gene

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