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Aliases for GPATCH3 Gene

Aliases for GPATCH3 Gene

  • G-Patch Domain Containing 3 2 3 5
  • GPATC3 3 4
  • G Patch Domain-Containing Protein 3 3

External Ids for GPATCH3 Gene

Previous HGNC Symbols for GPATCH3 Gene

  • GPATC3

Previous GeneCards Identifiers for GPATCH3 Gene

  • GC01M027090
  • GC01M027216
  • GC01M025470

Summaries for GPATCH3 Gene

GeneCards Summary for GPATCH3 Gene

GPATCH3 (G-Patch Domain Containing 3) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding.

Additional gene information for GPATCH3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPATCH3 Gene

Genomics for GPATCH3 Gene

Regulatory Elements for GPATCH3 Gene

Enhancers for GPATCH3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H026691 3.2 FANTOM5 Ensembl ENCODE dbSUPER 24.9 +204.0 204008 12.9 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A ZFP41 ARID1A HMGN2 LOC101928324 PIGV ACTG1P20 LOC101928728 GPN2 GPATCH3 TMEM222 LOC105376890
GH01H026721 3.1 VISTA Ensembl ENCODE dbSUPER 21.1 +177.4 177411 3.9 HDGF PKNOX1 ARNT SIN3A ARID4B FEZF1 DMAP1 ZNF2 YY1 ZNF766 ARID1A PIGV ACTG1P20 GPN2 GPATCH3 HMGN2 LOC101928324 LOC101928728 SELENON NPM1P39
GH01H026618 2.1 FANTOM5 Ensembl ENCODE dbSUPER 22.6 +280.7 280670 4 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 SP3 ZFP41 MEF2D ZNF610 ARID1A HMGN2 ACTG1P20 GPN2 ZNF593 AHDC1 GPATCH3 RPS6KA1 SELENON LOC101928324
GH01H026499 2.1 FANTOM5 Ensembl ENCODE dbSUPER 21.1 +399.9 399885 2.8 HDGF MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF766 LOC101928324 ARID1A GPATCH3 LIN28A DHDDS ENSG00000207302 LOC105376890 RPL39P7 RPS6KA1 NPM1P39
GH01H026856 1.8 FANTOM5 ENCODE dbSUPER 22.4 +39.3 39323 9.6 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF143 FOS DEK ARID1A HMGN2 LOC101928324 GPATCH3 LOC101928728 NPM1P39 PIGV RPS6KA1 GPN2 NUDC
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPATCH3 on UCSC Golden Path with GeneCards custom track

Promoters for GPATCH3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000003626 665 1601 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207

Genomic Locations for GPATCH3 Gene

Genomic Locations for GPATCH3 Gene
chr1:26,890,488-26,901,065
(GRCh38/hg38)
Size:
10,578 bases
Orientation:
Minus strand
chr1:27,216,979-27,226,962
(GRCh37/hg19)

Genomic View for GPATCH3 Gene

Genes around GPATCH3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPATCH3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPATCH3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPATCH3 Gene

Proteins for GPATCH3 Gene

  • Protein details for GPATCH3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96I76-GPTC3_HUMAN
    Recommended name:
    G patch domain-containing protein 3
    Protein Accession:
    Q96I76
    Secondary Accessions:
    • Q5JYH2
    • Q8NDJ2
    • Q9H9Z3

    Protein attributes for GPATCH3 Gene

    Size:
    525 amino acids
    Molecular mass:
    59338 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAD38742.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GPATCH3 Gene

Post-translational modifications for GPATCH3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPATCH3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPATCH3 Gene

Domains & Families for GPATCH3 Gene

Gene Families for GPATCH3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GPATCH3 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GPATCH3: view

No data available for UniProtKB/Swiss-Prot for GPATCH3 Gene

Function for GPATCH3 Gene

Phenotypes From GWAS Catalog for GPATCH3 Gene

Gene Ontology (GO) - Molecular Function for GPATCH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 28414768
genes like me logo Genes that share ontologies with GPATCH3: view
genes like me logo Genes that share phenotypes with GPATCH3: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPATCH3 Gene

Localization for GPATCH3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPATCH3 gene
Compartment Confidence
nucleus 3
cytosol 3
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPATCH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 28397860
GO:0005737 cytoplasm IDA 28397860
genes like me logo Genes that share ontologies with GPATCH3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GPATCH3 Gene

Pathways & Interactions for GPATCH3 Gene

SuperPathways for GPATCH3 Gene

No Data Available

Interacting Proteins for GPATCH3 Gene

Gene Ontology (GO) - Biological Process for GPATCH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0032480 negative regulation of type I interferon production IMP 28414768
GO:0039536 negative regulation of RIG-I signaling pathway IMP 28414768
GO:0045893 positive regulation of transcription, DNA-templated IDA 28397860
genes like me logo Genes that share ontologies with GPATCH3: view

No data available for Pathways by source and SIGNOR curated interactions for GPATCH3 Gene

Drugs & Compounds for GPATCH3 Gene

No Compound Related Data Available

Transcripts for GPATCH3 Gene

mRNA/cDNA for GPATCH3 Gene

Unigene Clusters for GPATCH3 Gene

G patch domain containing 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPATCH3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: - -
SP2:
SP3:
SP4:
SP5: -

Relevant External Links for GPATCH3 Gene

GeneLoc Exon Structure for
GPATCH3
ECgene alternative splicing isoforms for
GPATCH3

Expression for GPATCH3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPATCH3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPATCH3 Gene



Protein tissue co-expression partners for GPATCH3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPATCH3 Gene:

GPATCH3

SOURCE GeneReport for Unigene cluster for GPATCH3 Gene:

Hs.10903

Evidence on tissue expression from TISSUES for GPATCH3 Gene

  • Nervous system(4.8)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with GPATCH3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPATCH3 Gene

Orthologs for GPATCH3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPATCH3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPATCH3 33 34
  • 99.62 (n)
dog
(Canis familiaris)
Mammalia GPATCH3 33 34
  • 87.99 (n)
cow
(Bos Taurus)
Mammalia GPATCH3 33 34
  • 86.33 (n)
rat
(Rattus norvegicus)
Mammalia Gpatch3 33
  • 84.29 (n)
mouse
(Mus musculus)
Mammalia Gpatch3 33 16 34
  • 84.07 (n)
oppossum
(Monodelphis domestica)
Mammalia GPATCH3 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPATCH3 33 34
  • 66.09 (n)
lizard
(Anolis carolinensis)
Reptilia GPATCH3 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpatch3 33
  • 61.39 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16274 33
zebrafish
(Danio rerio)
Actinopterygii gpatch3 33 34
  • 62.39 (n)
Dr.8730 33
worm
(Caenorhabditis elegans)
Secernentea K07B1.7 33 34
  • 48.18 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 43 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7955 33
Species where no ortholog for GPATCH3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPATCH3 Gene

ENSEMBL:
Gene Tree for GPATCH3 (if available)
TreeFam:
Gene Tree for GPATCH3 (if available)

Paralogs for GPATCH3 Gene

No data available for Paralogs for GPATCH3 Gene

Variants for GPATCH3 Gene

Sequence variations from dbSNP and Humsavar for GPATCH3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000217807 -- 26,897,915(+) GAGGA(C/T)TGCTT intron-variant
rs1000321399 -- 26,897,359(+) CTCCA(C/T)AGGGG reference, missense
rs1000324343 -- 26,898,924(+) CCTCC(C/G)AAAGT intron-variant
rs1000378599 -- 26,898,641(+) CCAAA(A/C)AATTT intron-variant
rs1000431171 -- 26,891,842(+) AGCTG(A/G)GATTA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GPATCH3 Gene

Variant ID Type Subtype PubMed ID
nsv834524 CNV gain+loss 17160897
nsv1000012 CNV gain 25217958

Variation tolerance for GPATCH3 Gene

Residual Variation Intolerance Score: 58.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.92; 35.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPATCH3 Gene

Human Gene Mutation Database (HGMD)
GPATCH3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPATCH3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPATCH3 Gene

Disorders for GPATCH3 Gene

Relevant External Links for GPATCH3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPATCH3

No disorders were found for GPATCH3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPATCH3 Gene

Publications for GPATCH3 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Whole-Exome Sequencing of Congenital Glaucoma Patients Reveals Hypermorphic Variants in GPATCH3, a New Gene Involved in Ocular and Craniofacial Development. (PMID: 28397860) Ferre-Fernández JJ … Escribano J (Scientific reports 2017) 3 60
  5. GPATCH3 negatively regulates RLR-mediated innate antiviral responses by disrupting the assembly of VISA signalosome. (PMID: 28414768) Nie Y … Wang YY (PLoS pathogens 2017) 3 60

Products for GPATCH3 Gene

Sources for GPATCH3 Gene

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