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Aliases for GPATCH2 Gene

Aliases for GPATCH2 Gene

  • G-Patch Domain Containing 2 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 30 2 3
  • Cancer/Testis Antigen 110 2 3
  • GPATC2 3 4
  • G Patch Domain-Containing Protein 2 3
  • PPP1R30 3
  • CT110 3
  • Pfa1 3

External Ids for GPATCH2 Gene

Previous HGNC Symbols for GPATCH2 Gene

  • GPATC2

Previous GeneCards Identifiers for GPATCH2 Gene

  • GC01M215667
  • GC01M217600
  • GC01M188278

Summaries for GPATCH2 Gene

Entrez Gene Summary for GPATCH2 Gene

  • The gene encodes a nuclear factor that may play a role in spermatogenesis and in tumor growth during breast cancer. The encoded protein contains a G-patch domain with an RNA binding motif. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

GeneCards Summary for GPATCH2 Gene

GPATCH2 (G-Patch Domain Containing 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is GPATCH2L.

UniProtKB/Swiss-Prot for GPATCH2 Gene

  • Enhances the ATPase activity of DHX15 in vitro.

Additional gene information for GPATCH2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPATCH2 Gene

Genomics for GPATCH2 Gene

GeneHancer (GH) Regulatory Elements for GPATCH2 Gene

Promoters and enhancers for GPATCH2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I217629 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.1 102 2.2 PKNOX1 CLOCK FOXA2 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 ZBTB7B BRCA1 SPATA17 GPATCH2 GC01P217564
GH01I217659 Enhancer 0.9 Ensembl ENCODE 11.9 -29.8 -29796 2.6 CTCF PKNOX1 RAD21 ZNF316 GATA3 ZNF143 FOSL2 FOS MAFK ZNF654 SPATA17 GPATCH2 GC01M217679
GH01I217574 Enhancer 0.7 ENCODE 10.9 +56.3 56318 0.1 FOXA2 CTBP1 GATA3 CREM HOMEZ TCF7L2 MIXL1 GATAD2A SOX5 SMARCE1 SPATA17 GPATCH2 GC01P217564
GH01I217561 Enhancer 0.6 ENCODE 11.2 +68.4 68406 2.2 SMARCE1 CTCF DPF2 FOXA1 SP1 CTBP1 JUND GATA3 POLR2A CREB1 GC01P217564 GPATCH2 SPATA17 PIR51093
GH01I217564 Enhancer 0.4 UCNEbase 11.2 +66.7 66744 0.3 GC01P217564 GPATCH2 SPATA17
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GPATCH2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPATCH2 gene promoter:

Genomic Locations for GPATCH2 Gene

Genomic Locations for GPATCH2 Gene
chr1:217,426,992-217,631,102
(GRCh38/hg38)
Size:
204,111 bases
Orientation:
Minus strand
chr1:217,600,334-217,804,424
(GRCh37/hg19)

Genomic View for GPATCH2 Gene

Genes around GPATCH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPATCH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPATCH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPATCH2 Gene

Proteins for GPATCH2 Gene

  • Protein details for GPATCH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NW75-GPTC2_HUMAN
    Recommended name:
    G patch domain-containing protein 2
    Protein Accession:
    Q9NW75
    Secondary Accessions:
    • Q5VYK7
    • Q5VYK8
    • Q86YE7

    Protein attributes for GPATCH2 Gene

    Size:
    528 amino acids
    Molecular mass:
    58944 Da
    Quaternary structure:
    • Interacts with DHX15.

    Alternative splice isoforms for GPATCH2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPATCH2 Gene

Post-translational modifications for GPATCH2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for GPATCH2 Gene

Domains & Families for GPATCH2 Gene

Gene Families for GPATCH2 Gene

Protein Domains for GPATCH2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GPATCH2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GPATCH2: view

No data available for UniProtKB/Swiss-Prot for GPATCH2 Gene

Function for GPATCH2 Gene

Molecular function for GPATCH2 Gene

UniProtKB/Swiss-Prot Function:
Enhances the ATPase activity of DHX15 in vitro.

Phenotypes From GWAS Catalog for GPATCH2 Gene

Gene Ontology (GO) - Molecular Function for GPATCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with GPATCH2: view
genes like me logo Genes that share phenotypes with GPATCH2: view

Animal Model Products

miRNA for GPATCH2 Gene

miRTarBase miRNAs that target GPATCH2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPATCH2 Gene

Localization for GPATCH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPATCH2 Gene

Nucleus speckle. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPATCH2 gene
Compartment Confidence
nucleus 5
plasma membrane 2
cytoskeleton 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPATCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with GPATCH2: view

Pathways & Interactions for GPATCH2 Gene

SuperPathways for GPATCH2 Gene

No Data Available

Interacting Proteins for GPATCH2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000355902%0d%0a9606.ENSP00000262506%0d%0a9606.ENSP00000349465%0d%0a
Selected Interacting proteins: ENSP00000355902 Q9NW75-GPTC2_HUMAN for GPATCH2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for GPATCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010923 negative regulation of phosphatase activity IDA 19389623
genes like me logo Genes that share ontologies with GPATCH2: view

No data available for Pathways by source and SIGNOR curated interactions for GPATCH2 Gene

Drugs & Compounds for GPATCH2 Gene

No Compound Related Data Available

Transcripts for GPATCH2 Gene

Unigene Clusters for GPATCH2 Gene

G patch domain containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPATCH2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b
SP1: - - - - - - -
SP2: -
SP3: -
SP4: -
SP5: -
SP6:

Relevant External Links for GPATCH2 Gene

GeneLoc Exon Structure for
GPATCH2
ECgene alternative splicing isoforms for
GPATCH2

Expression for GPATCH2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPATCH2 Gene

Protein differential expression in normal tissues from HIPED for GPATCH2 Gene

This gene is overexpressed in Pancreatic juice (61.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GPATCH2 Gene



Protein tissue co-expression partners for GPATCH2 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPATCH2 Gene:

GPATCH2

SOURCE GeneReport for Unigene cluster for GPATCH2 Gene:

Hs.420757

mRNA Expression by UniProt/SwissProt for GPATCH2 Gene:

Q9NW75-GPTC2_HUMAN
Tissue specificity: Testis.

Evidence on tissue expression from TISSUES for GPATCH2 Gene

  • Lung(4.2)
  • Nervous system(3.2)
genes like me logo Genes that share expression patterns with GPATCH2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPATCH2 Gene

Orthologs for GPATCH2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPATCH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPATCH2 33 34
  • 99.75 (n)
cow
(Bos Taurus)
Mammalia GPATCH2 34
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPATCH2 33 34
  • 91.79 (n)
mouse
(Mus musculus)
Mammalia Gpatch2 33 16 34
  • 83.43 (n)
oppossum
(Monodelphis domestica)
Mammalia GPATCH2 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPATCH2 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPATCH2 33 34
  • 79.42 (n)
lizard
(Anolis carolinensis)
Reptilia GPATCH2 34
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpatch2 33
  • 70.57 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100330499 33
  • 61.16 (n)
gpatch2 34
  • 58 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 28 (a)
OneToMany
Species where no ortholog for GPATCH2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPATCH2 Gene

ENSEMBL:
Gene Tree for GPATCH2 (if available)
TreeFam:
Gene Tree for GPATCH2 (if available)

Paralogs for GPATCH2 Gene

Paralogs for GPATCH2 Gene

(2) SIMAP similar genes for GPATCH2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPATCH2: view

Variants for GPATCH2 Gene

Sequence variations from dbSNP and Humsavar for GPATCH2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs796052151 likely-benign, Long QT syndrome 217,431,206(-) CC/C coding_sequence_variant, downstream_transcript_variant, frameshift, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000019850 -- 217,519,948(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000021386 -- 217,610,700(-) A/C intron_variant
rs1000021668 -- 217,428,411(-) A/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000038538 -- 217,608,483(-) G/A 3_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GPATCH2 Gene

Variant ID Type Subtype PubMed ID
dgv263n106 CNV deletion 24896259
esv1658318 CNV deletion 17803354
esv2015860 CNV deletion 18987734
esv2572444 CNV deletion 19546169
esv2673939 CNV deletion 23128226
esv2722929 CNV deletion 23290073
esv2762164 CNV gain 21179565
esv2762166 CNV loss 21179565
esv3546755 CNV deletion 23714750
esv3588843 CNV gain 21293372
esv3588845 CNV loss 21293372
esv3588846 CNV loss 21293372
esv3768 CNV loss 18987735
esv8618 CNV loss 19470904
nsv1003999 CNV loss 25217958
nsv1008328 CNV gain 25217958
nsv1068860 CNV deletion 25765185
nsv1137848 CNV deletion 24896259
nsv1147085 CNV deletion 26484159
nsv159790 CNV deletion 16902084
nsv826631 CNV gain 20364138
nsv832559 CNV loss 17160897
nsv832570 CNV gain 17160897
nsv832581 CNV gain+loss 17160897
nsv952123 CNV duplication 24416366
nsv957533 CNV deletion 24416366

Variation tolerance for GPATCH2 Gene

Residual Variation Intolerance Score: 62.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.74; 57.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPATCH2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPATCH2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPATCH2 Gene

Disorders for GPATCH2 Gene

Additional Disease Information for GPATCH2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GPATCH2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPATCH2 Gene

Publications for GPATCH2 Gene

  1. Involvement of G-patch domain containing 2 overexpression in breast carcinogenesis. (PMID: 19432882) Lin ML … Katagiri T (Cancer science 2009) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Genome-wide gene-expression profiles of breast-cancer cells purified with laser microbeam microdissection: identification of genes associated with progression and metastasis. (PMID: 15375528) Nishidate T … Nakamura Y (International journal of oncology 2004) 2 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for GPATCH2 Gene

Sources for GPATCH2 Gene

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