Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GPATCH2 Gene

Aliases for GPATCH2 Gene

  • G-Patch Domain Containing 2 2 3 5
  • Cancer/Testis Antigen 110 2 3
  • GPATC2 3 4
  • Protein Phosphatase 1, Regulatory Subunit 30 3
  • G Patch Domain Containing 2 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 30 2
  • PPP1R30 3
  • CT110 3

External Ids for GPATCH2 Gene

Previous HGNC Symbols for GPATCH2 Gene

  • GPATC2

Previous GeneCards Identifiers for GPATCH2 Gene

  • GC01M215667
  • GC01M217600
  • GC01M188278

Summaries for GPATCH2 Gene

GeneCards Summary for GPATCH2 Gene

GPATCH2 (G-Patch Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is GPATCH2L.

UniProtKB/Swiss-Prot for GPATCH2 Gene

  • Enhances the ATPase activity of DHX15 in vitro.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPATCH2 Gene

Genomics for GPATCH2 Gene

Regulatory Elements for GPATCH2 Gene

Enhancers for GPATCH2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPATCH2 on UCSC Golden Path with GeneCards custom track

Promoters for GPATCH2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GPATCH2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPATCH2 Gene

217,426,992 bp from pter
217,631,102 bp from pter
204,111 bases
Minus strand

Genomic View for GPATCH2 Gene

Genes around GPATCH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPATCH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPATCH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPATCH2 Gene

Proteins for GPATCH2 Gene

  • Protein details for GPATCH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G patch domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • Q5VYK7
    • Q5VYK8
    • Q86YE7

    Protein attributes for GPATCH2 Gene

    528 amino acids
    Molecular mass:
    58944 Da
    Quaternary structure:
    • Interacts with DHX15.

    Alternative splice isoforms for GPATCH2 Gene


neXtProt entry for GPATCH2 Gene

Proteomics data for GPATCH2 Gene at MOPED

Post-translational modifications for GPATCH2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPATCH2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPATCH2 Gene

Domains & Families for GPATCH2 Gene

Protein Domains for GPATCH2 Gene


Suggested Antigen Peptide Sequences for GPATCH2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 G-patch domain.
  • Contains 1 G-patch domain.
genes like me logo Genes that share domains with GPATCH2: view

Function for GPATCH2 Gene

Molecular function for GPATCH2 Gene

UniProtKB/Swiss-Prot Function:
Enhances the ATPase activity of DHX15 in vitro.
genes like me logo Genes that share phenotypes with GPATCH2: view

Animal Model Products

CRISPR Products

miRNA for GPATCH2 Gene

miRTarBase miRNAs that target GPATCH2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPATCH2 Gene

Localization for GPATCH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPATCH2 Gene

Nucleus speckle. Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for GPATCH2 Gene COMPARTMENTS Subcellular localization image for GPATCH2 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for GPATCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with GPATCH2: view

Pathways & Interactions for GPATCH2 Gene

SuperPathways for GPATCH2 Gene

No Data Available

Interacting Proteins for GPATCH2 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000355902 for GPATCH2 Gene via STRING

Gene Ontology (GO) - Biological Process for GPATCH2 Gene


No data available for Pathways by source and SIGNOR curated interactions for GPATCH2 Gene

Drugs & Compounds for GPATCH2 Gene

No Compound Related Data Available

Transcripts for GPATCH2 Gene

Unigene Clusters for GPATCH2 Gene

G patch domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPATCH2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b
SP1: - - - - - - -
SP2: -
SP3: -
SP4: -
SP5: -

Relevant External Links for GPATCH2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPATCH2 Gene

mRNA expression in normal human tissues for GPATCH2 Gene

Protein differential expression in normal tissues from HIPED for GPATCH2 Gene

This gene is overexpressed in Pancreatic juice (61.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GPATCH2 Gene

SOURCE GeneReport for Unigene cluster for GPATCH2 Gene Hs.420757

mRNA Expression by UniProt/SwissProt for GPATCH2 Gene

Tissue specificity: Testis.
genes like me logo Genes that share expression patterns with GPATCH2: view

Protein tissue co-expression partners for GPATCH2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for GPATCH2 Gene

Orthologs for GPATCH2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPATCH2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia GPATCH2 35
  • 91.79 (n)
  • 94.51 (a)
  • 94 (a)
(Mus musculus)
Mammalia Gpatch2 35
  • 83.43 (n)
  • 84.63 (a)
Gpatch2 16
Gpatch2 36
  • 84 (a)
(Pan troglodytes)
Mammalia GPATCH2 35
  • 99.75 (n)
  • 99.62 (a)
  • 100 (a)
(Bos Taurus)
Mammalia GPATCH2 36
  • 92 (a)
(Monodelphis domestica)
Mammalia GPATCH2 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia GPATCH2 36
  • 74 (a)
(Gallus gallus)
Aves GPATCH2 35
  • 79.42 (n)
  • 78.09 (a)
  • 77 (a)
(Anolis carolinensis)
Reptilia GPATCH2 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpatch2 35
  • 70.57 (n)
  • 74.95 (a)
(Danio rerio)
Actinopterygii LOC100330499 35
  • 61.16 (n)
  • 61.86 (a)
gpatch2 36
  • 58 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
Species with no ortholog for GPATCH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPATCH2 Gene

Gene Tree for GPATCH2 (if available)
Gene Tree for GPATCH2 (if available)

Paralogs for GPATCH2 Gene

Paralogs for GPATCH2 Gene

(2) SIMAP similar genes for GPATCH2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPATCH2: view

Variants for GPATCH2 Gene

Sequence variations from dbSNP and Humsavar for GPATCH2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs166449 -- 217,430,782(+) GAAAC(C/T)GGTGG downstream-variant-500B, utr-variant-3-prime
rs169085 -- 217,432,977(+) GACCA(C/T)GTCTT intron-variant
rs171946 -- 217,426,886(-) GCAAG(C/T)GGACC downstream-variant-500B
rs265114 -- 217,457,286(+) AAGTC(C/T)GCTTA intron-variant
rs265123 -- 217,427,439(-) AAATT(G/T)GTTTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GPATCH2 Gene

Variant ID Type Subtype PubMed ID
nsv832559 CNV Loss 17160897
nsv832570 CNV Gain 17160897
nsv826631 CNV Gain 20364138
nsv832581 CNV Gain+Loss 17160897
esv2673939 CNV Deletion 23128226
nsv873181 CNV Gain 21882294
nsv873182 CNV Loss 21882294
esv2572444 CNV Deletion 19546169
esv2015860 CNV Deletion 18987734
esv3768 CNV Deletion 18987735
esv2722929 CNV Deletion 23290073
nsv159790 CNV Loss 16902084
esv8618 CNV Loss 19470904
esv1658318 CNV Deletion 17803354

Variation tolerance for GPATCH2 Gene

Residual Variation Intolerance Score: 62.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.74; 57.77% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GPATCH2 Gene

Disorders for GPATCH2 Gene

Relevant External Links for GPATCH2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GPATCH2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPATCH2 Gene

Publications for GPATCH2 Gene

  1. Involvement of G-patch domain containing 2 overexpression in breast carcinogenesis. (PMID: 19432882) Lin M.L. … Katagiri T. (Cancer Sci. 2009) 2 3 4 67
  2. Genome-wide gene-expression profiles of breast-cancer cells purified with laser microbeam microdissection: identification of genes associated with progression and metastasis. (PMID: 15375528) Nishidate T. … Nakamura Y. (Int. J. Oncol. 2004) 2 3
  3. G-patch domain containing 2, a gene highly expressed in testes, inhibits nuclear factor-I_B and cell proliferation. (PMID: 25376275) Hu F. … Zhang X. (Mol Med Rep 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3

Products for GPATCH2 Gene

Sources for GPATCH2 Gene